A microfluidic chip manufacturing device

Abstract

The application relates to a micro-fluidic chip manufacturing device and relates to the technical field of micro-fluidic chip manufacturing. The application aims to solve the problems that manual manufacturing of a micro-fluidic chip is time-consuming and laborious, deviation is caused in the operation process, and the precision is low. The micro-fluidic chip manufacturing device comprises a moving device, a fixed device and a rotating platform. The moving device is used for driving the working surface of a cutting and punching device to approach or move away from the bearing surface of the fixed device, and the fixed device is used for fixing the material for manufacturing the micro-fluidic chip. The upper surface of the rotating platform is a connecting surface, the lower surface of the rotating platform comprises two mirror-symmetrically arranged inclined surfaces, the punching module and the edge cutting module are respectively fixed on the two inclined surfaces, the rotating motor is fixed on the moving device through the suspension support module, the rotating shaft of the rotating motor is fixedly connected with the connecting surface, and when the rotating motor drives the rotating platform to rotate, the working surface of the punching module or the edge cutting module can be parallel to and face the bearing surface of the fixed device.

Description

Technical Field

[0001] This invention belongs to the field of microfluidic chip fabrication technology. Background Technology

[0002] Microfluidic chip technology is a technique that uses microchannels on a chip at the micrometer scale to precisely control, manipulate, and generate microscale fluids. It has developed into a new research field that intersects with disciplines such as biology, chemistry, medicine, fluid mechanics, electronics, materials, and mechanics.

[0003] Fabricating microfluidic chips requires not only specific plasma treatment but also a series of steps including drilling, trimming, and bonding. Currently, most microfluidic chip fabrication in university and research institution laboratories is done manually. Microfluidic chips are generally for single use only. Manual fabrication is not only time-consuming and labor-intensive, but also suffers from low precision due to variations in drilling location, trimming shape and size, and bonding distance each time, hindering its widespread application in subsequent precision mechanical operations. Summary of the Invention

[0004] The present invention addresses the problems of manual fabrication of microfluidic chips, which are not only time-consuming and labor-intensive, but also prone to deviations and low precision during the operation process. A device for fabricating microfluidic chips is provided.

[0005] A microfluidic chip fabrication apparatus includes: a moving device 1, a cutting and drilling device 2, and a fixing device 3. The moving device 1 is used to move the working surface of the cutting and drilling device 2 closer to or away from the bearing surface of the fixing device 3, and the fixing device 3 is used to fix the material for fabricating the microfluidic chip.

[0006] The cutting and punching device 2 includes: a rotating platform 2-1, a punching module 2-2, an edge trimming module 2-3, a rotating motor 2-4, and a suspension support module 2-5;

[0007] The punching module 2-2 is used to punch holes in the PDMS material, and the edge cutting module 2-3 is used to cut the PDMS material;

[0008] The upper surface of the rotating platform 2-1 is a connecting surface, and the lower surface of the rotating platform 2-1 includes two mirror-symmetrical inclined surfaces. The drilling module 2-2 and the trimming module 2-3 are respectively fixed on the two inclined surfaces.

[0009] The rotary motor 2-4 is fixed to the moving device 1 by the suspension support module 2-5. The rotating shaft of the rotary motor 2-4 is fixedly connected to the connecting surface. When the rotary motor 2-4 drives the rotating platform 2-1 to rotate, the working surface of the punching module 2-2 or the trimming module 2-3 is parallel to and directly opposite the bearing surface of the fixing device 3.

[0010] Furthermore, the aforementioned punching module 2-2 includes a main board and multiple punches. The main board is rectangular, and a slot is formed along one of its center lines. The multiple punches are embedded in the slot and can move along the slot.

[0011] Furthermore, each punch has a screw fixed to the back, which passes from one side of the motherboard to the other side and is threaded into a nut.

[0012] Furthermore, the edges of the aforementioned grooves are marked with graduations.

[0013] Furthermore, the aforementioned mobile device 1 includes: a support frame 1-1, a mobile platform 1-2, two flange nuts 1-3, a first lead screw 1-4, a driven wheel 1-5, a base 1-6, a synchronous belt 1-7, a driving wheel 1-8, a second lead screw 1-9, and a mobile motor 1-11;

[0014] The fixing device 3 is located on the upper surface of the base 1-6;

[0015] The mobile platform 1-2 has a strip-shaped plate structure. There is a through hole near each end of the mobile platform 1-2. The first lead screw 1-4 and the second lead screw 1-9 pass through the two through holes respectively, so that the first lead screw 1-4 and the second lead screw 1-9 are mirror symmetrical. The two flange nuts 1-3 are threaded to the first lead screw 1-4 and the second lead screw 1-9 respectively, and both flange nuts 1-3 are fixed to the lower surface of the mobile platform 1-2.

[0016] The support frame 1-1 is fixed to one side of the base 1-6. The support frame 1-1 is used to support the first lead screw 1-4 and the first lead screw 1-4 is rotatably engaged with the support frame 1-1. The first lead screw 1-4 is perpendicular to the upper surface of the base 1-6.

[0017] The end of the second lead screw 1-9 is rotatably engaged with the other side of the base 1-6. The moving motor 1-11 is located above the moving platform 1-2. The rotating shaft of the moving motor 1-11 is coaxially and fixedly connected to the top end of the second lead screw 1-9.

[0018] The driven wheel 1-5 is coaxially fixed to the end of the first lead screw 1-4, the driving wheel 1-8 is coaxially fixed to the end of the second lead screw 1-9, and the synchronous belt 1-7 meshes with both the driven wheel 1-5 and the driving wheel 1-8.

[0019] When the moving motor 1-11 rotates, it can sequentially drive the first lead screw 1-4 to rotate through the second lead screw 1-9, the driving wheel 1-8, the synchronous belt 1-7, and the driven wheel 1-5, so that the moving platform 1-2 can move along the length direction of the first lead screw 1-4 and the second lead screw 1-9.

[0020] Furthermore, the shaft of the aforementioned mobile motor 1-11 is coaxially and fixedly connected to the top end of the second lead screw 1-9 via the coupling 1-10.

[0021] Furthermore, both the first lead screw 1-4 and the second lead screw 1-9 are rotatably coupled to the base 1-6 via deep groove ball bearings.

[0022] Furthermore, the aforementioned fixing device 3 includes: a core carrier platform 3-1, four grippers, a gripper motor 3-3, a track plate 3-4, a longitudinal track 3-11, and a transverse track 3-14;

[0023] The upper surface of the base 1-6 has a motor cavity 1-12, and the gripper motor 3-3 is located in the motor cavity 1-12. The rotating shaft of the gripper motor 3-3 is perpendicularly fixed to the center of the track plate 3-4, so that the track plate 3-4 is parallel to the upper surface of the base 1-6. The track plate 3-4 has four 180° arc-shaped tracks. One end of each of the four arc-shaped tracks is located on a circle with the center of the track plate 3-4 as the center and they are 90° apart from each other. One end of each of the four arc-shaped tracks is located on another circle with the center of the track plate 3-4 as the center. The openings of the four arc-shaped tracks are all oriented in a clockwise or counterclockwise direction. The four grippers are respectively embedded in the four arc-shaped tracks.

[0024] The core carrier platform 3-1 is mounted above the track slab 3-4 via support columns. The core carrier platform 3-1 has longitudinal tracks 3-11 and transverse tracks 3-14, which intersect perpendicularly with their intersection point directly opposite the center of the track slab 3-4. Two non-adjacent grippers of the four clamps are embedded in the longitudinal tracks 3-11, and the remaining two grippers are embedded in the transverse tracks 3-14. The upper surface has a float glass groove 3-12 for placing float glass 4-2. The float glass groove 3-12 has a PDMS material groove 3-13 for placing PDMS material block 4-1. The geometric center of the float glass groove 3-12 and the PDMS material groove 3-13 coincides with the intersection of the longitudinal track 3-11 and the transverse track 3-14. The PDMS material groove 3-13 is provided with a blade groove 3-15 that is directly opposite to the cutting blade on the edge cutting module 2-3.

[0025] When the gripper motor 3-3 drives the track plate 3-4 to rotate, the four grippers can simultaneously converge toward the center of the track plate 3-4 or disperse toward the edge of the track plate 3-4.

[0026] Furthermore, the four grippers described above consist of two long grippers 3-2 and two short grippers 3-5.

[0027] The two long grippers 3-2 are simultaneously located within the longitudinal track 3-11 or the transverse track 3-14.

[0028] The two short grippers 3-5 are simultaneously located within the horizontal track 3-14 or the vertical track 3-11.

[0029] Furthermore, a control cavity is formed on the upper surface of the base 1-6, which is used to house a controller. The controller is used to drive the rotary motor 2-4, the moving motor 1-11, and the gripper motor 3-3 to rotate forward or reverse, and to start or stop them.

[0030] The beneficial effects of this invention include:

[0031] 1. This invention eliminates the limitations of manual operation through mechanical automation, making the device more efficient and easier to operate during the fabrication of microfluidic chips.

[0032] 2. The present invention has a compact overall structure, is easy to carry, and is not limited by the laboratory and complex and diverse experimental tools, and has good adaptability to experimental environments.

[0033] 3. This invention, through a series of steps, standardizes the appearance, size, and shape of the fabricated microfluidic chips, with only the internal microchannels differing. This allows for the fabrication of different types of chips to perform different functions, thereby improving experimental efficiency.

[0034] 4. The punching module and the edge trimming module in this invention are detachable and replaceable, and the hole spacing and number of the punching module are adjustable, which can be well applied to the fabrication of chips with different requirements, types and shapes. Attached Figure Description

[0035] Figure 1 This is a schematic diagram of the overall structure of a microfluidic chip fabrication device;

[0036] Figure 2 This is a schematic diagram of the mobile device.

[0037] Figure 3 This is a discrete schematic diagram of a cutting and drilling device;

[0038] Figure 4 This is a schematic diagram of the punching module;

[0039] Figure 5This is a discrete schematic diagram of a fixed device;

[0040] Figure 6 This is a schematic diagram of the track slab plan;

[0041] Figure 7 This is a schematic diagram of the core carrier platform;

[0042] Figure 8 This is a schematic diagram of a microfluidic chip;

[0043] Figure 9 A schematic diagram of drilling holes in a PDMS material block;

[0044] Figure 10 This is a schematic diagram of the cut edge of a PDMS material block;

[0045] Figure 11 A schematic diagram showing the placement of float glass.

[0046] Figure 12 This is a schematic diagram showing the completion of microfluidic chip bonding.

[0047] In the diagram: 1. Moving device; 2. Cutting and drilling device; 3. Fixing device; 1-1. Support frame; 1-2. Moving platform; 1-3. Flange nut; 1-4. First lead screw; 1-5. Driven wheel; 1-6. Base; 1-7. Synchronous belt; 1-8. Drive wheel; 1-9. Second lead screw; 1-10. Coupling; 1-11. Moving motor; 1-12. Motor cavity; 2-1. Rotating platform; 2-2. Drilling module; 2-3. Edge trimming module; 2-4. Rotating motor; 2-5. Suspension support module; 3-1. Core carrier platform; 3-2. Long gripper; 3-3. Gripper motor; 3-4. Track plate; 3-5. Short gripper; 3-11. Longitudinal track; 3-12. Float glass tank; 3-13. PDMS material tank; 3-14. Horizontal track; 3-15. Blade slot; 4-1. PDMS material block; 4-2. Float glass. Detailed Implementation

[0048] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of the present invention can be combined with each other.

[0049] Specific implementation method one: Refer to Figures 1 to 7 This embodiment describes a microfluidic chip fabrication apparatus, comprising: a moving device 1, a cutting and drilling device 2, and a fixing device 3. For example... Figure 1As shown, the moving device 1 is used to move the working surface of the cutting and drilling device 2 closer to or away from the bearing surface of the fixing device 3. The fixing device 3 is used to fix the PDMS material block 4-1 and float glass 4-2 for fabricating microfluidic chips.

[0050] The moving device 1 includes: a support frame 1-1, a moving platform 1-2, two flange nuts 1-3, a first lead screw 1-4, a driven wheel 1-5, a base 1-6, a synchronous belt 1-7, a driving wheel 1-8, a second lead screw 1-9, and a moving motor 1-11. The cutting and drilling device 2 includes: a rotating platform 2-1, a drilling module 2-2, a trimming module 2-3, a rotating motor 2-4, and a suspension support module 2-5. The fixing device 3 includes: a core-carrying platform 3-1, four grippers, a gripper motor 3-3, a track plate 3-4, a longitudinal track 3-11, and a transverse track 3-14.

[0051] The mobile platform 1-2 has a strip-shaped plate structure. A through hole is opened near each end of the mobile platform 1-2. The first lead screw 1-4 and the second lead screw 1-9 pass through the two through holes respectively, making the first lead screw 1-4 and the second lead screw 1-9 mirror symmetrical. The two flange nuts 1-3 are threadedly connected to the first lead screw 1-4 and the second lead screw 1-9 respectively, and both flange nuts 1-3 are fixed to the lower surface of the mobile platform 1-2.

[0052] like Figure 2 As shown, support frame 1-1 is fixed to one side of base 1-6. Support frame 1-1 supports the first lead screw 1-4, and the first lead screw 1-4 is rotatably engaged with support frame 1-1. The first lead screw 1-4 is perpendicular to the upper surface of base 1-6. The end of the second lead screw 1-9 is rotatably engaged with the other side of base 1-6. The moving motor 1-11 is located above the moving platform 1-2. The rotating shaft of the moving motor 1-11 is coaxially fixedly connected to the top end of the second lead screw 1-9 through coupling 1-10. Both the first lead screw 1-4 and the second lead screw 1-9 are rotatably engaged with base 1-6 through deep groove ball bearings. Driven wheel 1-5 is coaxially sleeved on the end of the first lead screw 1-4, and driving wheel 1-8 is coaxially sleeved on the end of the second lead screw 1-9. The synchronous belt 1-7 meshes with both driven wheel 1-5 and driving wheel 1-8. When the moving motor 1-11 rotates, it can sequentially drive the first lead screw 1-4 to rotate through the second lead screw 1-9, the driving wheel 1-8, the synchronous belt 1-7, and the driven wheel 1-5, so that the moving platform 1-2 can move along the length direction of the first lead screw 1-4 and the second lead screw 1-9.

[0053] like Figure 3As shown, the upper surface of the rotating platform 2-1 is a circular connecting surface, and the lower surface of the rotating platform 2-1 is an arc-shaped surface with two mirror-symmetrical inclined surfaces. The drilling module 2-2 and the trimming module 2-3 are respectively fixed on the two inclined surfaces. The rotary motor 2-4 is fixed to the lower surface of the moving platform 1-2 through the suspension support module 2-5. The rotating shaft of the rotary motor 2-4 is fixedly connected to the connecting surface. When the rotary motor 2-4 drives the rotating platform 2-1 to rotate, the working surface of the drilling module 2-2 or the trimming module 2-3 is parallel to and directly opposite the bearing surface of the fixing device 3. Figure 4 As shown, the punching module 2-2 includes a main board and multiple punches. The main board is rectangular, with a slot along one of its center lines. The punches are embedded in this slot and can move along it. Each punch has a screw fixed to its back, which passes from one side of the main board to the other and is threaded onto a nut. The slot is marked with graduations. The punching module 2-2 is used to punch holes in PDMS material, and the trimming module 2-3 is used to cut the PDMS material. In practical applications, these modules can be replaced and adjusted according to the microfluidic chip to be manufactured.

[0054] like Figure 5 As shown, a motor cavity 1-12 is formed on the upper surface of the base 1-6. The gripper motor 3-3 is located within the motor cavity 1-12. The rotating shaft of the gripper motor 3-3 is perpendicularly and fixedly connected to the center of the track plate 3-4, so that the track plate 3-4 is parallel to the upper surface of the base 1-6. Figure 6 As shown, the track plate 3-4 has four 180° arc-shaped tracks. One end of each of the four arc-shaped tracks lies on a circle centered on the center of the track plate 3-4, and they are 90° apart. The other end of each arc-shaped track lies on another circle centered on the center of the track plate 3-4. The openings of the four arc-shaped tracks all face clockwise or counterclockwise. The four grippers are respectively embedded within the four arc-shaped tracks. The core carrier platform 3-1 is supported above the track plate 3-4 by support columns. Figure 7As shown, the core carrier platform 3-1 has a longitudinal track 3-11 and a transverse track 3-14. The longitudinal track 3-11 and the transverse track 3-14 are arranged perpendicularly to each other, and the intersection point is directly opposite to the center of the track plate 3-4. Two non-adjacent grippers of the four grippers are embedded in the longitudinal track 3-11, and the remaining two grippers are embedded in the transverse track 3-14. The upper surface of the core carrier platform 3-1 has a float glass groove 3-12 for placing float glass 4-2. The float glass groove 3-12 has a PDMS material groove 3-13 for placing PDMS material block 4-1. The geometric center of the float glass groove 3-12 and the PDMS material groove 3-13 coincides with the intersection point of the longitudinal track 3-11 and the transverse track 3-14. The PDMS material groove 3-13 has a blade groove 3-15 that is directly opposite to the cutting blade on the edge cutting module 2-3. The four grippers consist of two long grippers 3-2 and two short grippers 3-5. The two long grippers 3-2 are simultaneously located within the longitudinal track 3-11 or the transverse track 3-14, and the two short grippers 3-5 are simultaneously located within the transverse track 3-14 or the longitudinal track 3-11. A control cavity is formed on the upper surface of the base 1-6. This control cavity houses a controller, which drives the rotary motor 2-4, the moving motor 1-11, and the gripper motor 3-3 to rotate forward or reverse, and to start or stop them. When the gripper motor 3-3 drives the track plate 3-4 to rotate, the four grippers can simultaneously converge towards the center of the track plate 3-4 or disperse towards its edge.

[0055] The principle behind this implementation method in practical applications is as follows:

[0056] like Figure 9 As shown, initially, the microfluidic chip fabrication apparatus provided in this embodiment is placed on a stationary platform. The cutting and drilling device 2 is in a higher position, the grippers of the fixing device 3 are in a relaxed state, and the drilling module 2-2 and the PDMS material tank 3-13 are directly opposite each other. The moving motor 1-11, the rotating motor 2-4, and the gripper motor 3-3 are all in a closed and stationary state, and there is no material on the core carrier platform 3-1.

[0057] During operation, the PDMS material block 4-1 is placed into the PDMS material tank 3-13. The gripper motor 3-3 starts, driving the track plate 3-4 to rotate. The four grippers simultaneously move towards the center of the track plate 3-4 along their respective tracks until the PDMS material block 4-1 is clamped, at which point the gripper motor 3-3 stops rotating. The moving motor 1-11 is then started, driving the cutting and punching device 2 downwards until a hole is punched in the PDMS material block 4-1. The moving motor 1-11 rotates in the opposite direction, driving the cutting and punching device 2 upwards until the punching module 2-2 and the PDMS material block 4-1 separate.

[0058] Rotary motor 2-4 rotates 180°, aligning the trimming module 2-3 and the PDMS material tank 3-13. Moving motor 1-11 restarts, driving the cutting and punching device 2 downwards until the trimming is completed on the PDMS material block 4-1. Figure 10 As shown.

[0059] The moving motor 1-11 stops rotating, and the gripper motor 3-3 rotates in the opposite direction. Driven by the track plate 3-4, the four grippers move in opposite directions, releasing the PDMS material block 4-1. Afterward, the gripper motor 3-3 stops rotating. The moving motor 1-11 rotates in the opposite direction again, driving the cutting and drilling device 2 to move upward. Due to the elasticity of the PDMS material block 4-1, it can be embedded into the edge-cutting module 2-3 and move upward along with the cutting and drilling device 2. The float glass 4-2 is then placed into the float glass tank 3-12. Figure 11 As shown.

[0060] The moving motor 1-11 rotates for the third time, driving the cutting and drilling device 2 and the PDMS material block 4-1 downwards until the PDMS material block 4-1 contacts the float glass 4-2. The moving motor 1-11 stops rotating, and the gripper motor 3-3 rotates. Driven by the track plate 3-4, the four grippers move towards each other, confining the float glass 4-2 within the float glass tank 3-12. The moving motor 1-11 then rotates in the reverse direction for the third time. Due to the strong bonding force between the PDMS material block 4-1 and the float glass 4-2, the cutting and drilling device 2 moves upwards, separating the PDMS material block 4-1 from the edge-cutting module 2-3. The gripper motor 3-3 then rotates in the reverse direction, releasing the constraint on the float glass 4-2. Figure 12 As shown, the fabrication of the microfluidic chip is complete.

[0061] In this embodiment, through automated mechanical operation and the flexible use of the gripper-type fixing device, the up-and-down moving device rotates back and forth three times. With the assistance of the rotary straight-cutting device, the drilling, edge trimming, and bonding operations in the microfluidic chip fabrication process are completed, helping to design and manufacture standardized chips suitable for different requirements. This embodiment eliminates the limitations of manual operation and experimental materials, improving the convenience and efficiency of experiments.

[0062] While the invention has been described herein with reference to specific embodiments, it should be understood that these embodiments are merely examples of the principles and applications of the invention. Therefore, it should be understood that many modifications can be made to the exemplary embodiments, and other arrangements can be designed without departing from the spirit and scope of the invention as defined by the appended claims. It should be understood that different dependent claims and features described herein can be combined in ways different from those described in the original claims. It is also understood that features described in conjunction with individual embodiments can be used in other described embodiments.

Claims

1. An apparatus for fabricating a microfluidic chip, characterized in that, include: The moving device (1), the cutting and drilling device (2), and the fixing device (3) are used to move the working surface of the cutting and drilling device (2) closer to or away from the bearing surface of the fixing device (3), and the fixing device (3) is used to fix the material for making microfluidic chips. The cutting and punching device (2) includes: a rotating platform (2-1), a punching module (2-2), a cutting module (2-3), a rotating motor (2-4), and a suspension support module (2-5). The punching module (2-2) is used to punch holes in the PDMS material, and the cutting module (2-3) is used to cut the PDMS material; The upper surface of the rotating platform (2-1) is a connecting surface, and the lower surface of the rotating platform (2-1) includes two mirror-symmetrical inclined surfaces. The drilling module (2-2) and the trimming module (2-3) are respectively fixed on the two inclined surfaces. The rotary motor (2-4) is fixed to the moving device (1) via the suspension support module (2-5). The rotating shaft of the rotary motor (2-4) is fixedly connected to the connecting surface. When the rotary motor (2-4) drives the rotating platform (2-1) to rotate, the working surface of the punching module (2-2) or the trimming module (2-3) is parallel to and directly opposite the bearing surface of the fixing device (3). The moving device (1) includes: a base (1-6), and the fixing device (3) is located on the upper surface of the base (1-6); The fixing device (3) includes: a core carrier platform (3-1), the upper surface of the core carrier platform (3-1) is provided with a float glass groove (3-12) for placing float glass (4-2), the float glass groove (3-12) is provided with a PDMS material groove (3-13) for placing PDMS material block (4-1), and the PDMS material groove (3-13) is provided with a blade groove (3-15) that is directly opposite to the cutting blade on the cutting module (2-3). After the edge trimming is completed, due to the elasticity of the PDMS material block (4-1), the PDMS material block (4-1) can be embedded into the edge trimming module (2-3) and move upward together with the cutting and drilling device (2) to place the float glass (4-2) into the float glass tank (3-12); when the cutting and drilling device (2) and the PDMS material block (4-1) move downward until the PDMS material block (4-1) contacts the float glass (4-2), due to the huge bonding force between the PDMS material block (4-1) and the float glass (4-2), the cutting and drilling device (2) separates the PDMS material block (4-1) and the edge trimming module (2-3) when it moves upward.

2. The microfluidic chip fabrication apparatus according to claim 1, characterized in that, The punching module (2-2) includes a main board and multiple punches. The main board is rectangular, and a slot is formed along one of its center lines. The multiple punches are embedded in the slot and can move along the slot.

3. The apparatus for fabricating a microfluidic chip according to claim 2, characterized in that, Each punch has a screw fixed to the back, which passes from one side of the motherboard to the other side and is threaded into a nut.

4. The apparatus for fabricating a microfluidic chip according to claim 2 or 3, characterized in that, The edge of the groove is marked with graduations.

5. The apparatus for fabricating a microfluidic chip according to claim 1, characterized in that, The mobile device (1) further includes: a support frame (1-1), a mobile platform (1-2), two flange nuts (1-3), a first lead screw (1-4), a driven wheel (1-5), a synchronous belt (1-7), a driving wheel (1-8), a second lead screw (1-9), and a mobile motor (1-11). The mobile platform (1-2) has a strip-shaped plate structure. There is a through hole at each end of the mobile platform (1-2). The first lead screw (1-4) and the second lead screw (1-9) pass through the two through holes respectively, so that the first lead screw (1-4) and the second lead screw (1-9) are mirror symmetrical. The two flange nuts (1-3) are threaded to the first lead screw (1-4) and the second lead screw (1-9) respectively, and both flange nuts (1-3) are fixed to the lower surface of the mobile platform (1-2). The support frame (1-1) is fixed to one side of the base (1-6). The support frame (1-1) is used to support the first lead screw (1-4), and the first lead screw (1-4) is rotatably engaged with the support frame (1-1). The first lead screw (1-4) is perpendicular to the upper surface of the base (1-6). The end of the second lead screw (1-9) is rotatably engaged with the other side of the base (1-6), the moving motor (1-11) is located above the moving platform (1-2), and the rotating shaft of the moving motor (1-11) is coaxially and fixedly connected to the top end of the second lead screw (1-9). The driven wheel (1-5) is coaxially fixed to the end of the first lead screw (1-4), the driving wheel (1-8) is coaxially fixed to the end of the second lead screw (1-9), and the synchronous belt (1-7) meshes with both the driven wheel (1-5) and the driving wheel (1-8). When the moving motor (1-11) rotates, it can drive the first lead screw (1-4) to rotate in sequence through the second lead screw (1-9), the driving wheel (1-8), the synchronous belt (1-7), and the driven wheel (1-5), so that the moving platform (1-2) can move along the length direction of the first lead screw (1-4) and the second lead screw (1-9).

6. The microfluidic chip fabrication apparatus according to claim 5, characterized in that, The rotating shaft of the mobile motor (1-11) is coaxially and fixedly connected to the top end of the second lead screw (1-9) via a coupling (1-10).

7. The microfluidic chip fabrication apparatus according to claim 5, characterized in that, Both the first lead screw (1-4) and the second lead screw (1-9) are rotatably coupled to the base (1-6) via deep groove ball bearings.

8. The apparatus for fabricating a microfluidic chip according to claim 5, characterized in that, The fixing device (3) also includes: four grippers, a gripper motor (3-3), a track plate (3-4), a longitudinal track (3-11), and a transverse track (3-14); The upper surface of the base (1-6) has a motor cavity (1-12), and the gripper motor (3-3) is located in the motor cavity (1-12). The rotating shaft of the gripper motor (3-3) is fixedly connected to the center of the track plate (3-4) perpendicularly, so that the track plate (3-4) and the upper surface of the base (1-6) are parallel to each other. The track plate (3-4) has four 180° arc tracks. One end of each of the four arc tracks is located on a circle with the center of the track plate (3-4) as the center and they are 90° apart from each other. One end of each of the four arc tracks is located on another circle with the center of the track plate (3-4) as the center. The openings of the four arc tracks are all oriented in a clockwise or counterclockwise direction. The four grippers are respectively embedded in the four arc tracks. The core carrier platform (3-1) is mounted above the track plate (3-4) by support columns. The core carrier platform (3-1) has a longitudinal track (3-11) and a transverse track (3-14). The longitudinal track (3-11) and the transverse track (3-14) are arranged perpendicularly to each other and the intersection point is directly opposite to the center of the track plate (3-4). Two non-adjacent grippers of the four grippers are embedded in the longitudinal track (3-11), and the remaining two grippers of the four grippers are embedded in the transverse track (3-14). The geometric center of the float glass tank (3-12) and the PDMS material tank (3-13) coincides with the intersection point of the longitudinal track (3-11) and the transverse track (3-14). When the gripper motor (3-3) drives the track plate (3-4) to rotate, the four grippers can simultaneously converge toward the center of the track plate (3-4) or disperse toward the edge of the track plate (3-4).

9. The microfluidic chip fabrication apparatus according to claim 8, characterized in that, The four grippers consist of two long grippers (3-2) and two short grippers (3-5). The two long grippers (3-2) are simultaneously located within the longitudinal track (3-11) or the transverse track (3-14). The two short grippers (3-5) are simultaneously located within the horizontal track (3-14) or the vertical track (3-11).

10. The apparatus for fabricating a microfluidic chip according to claim 8, characterized in that, The upper surface of the base (1-6) has a control cavity for housing a controller. The controller is used to drive the rotary motor (2-4), the moving motor (1-11), and the gripper motor (3-3) to rotate forward or reverse, and to start or stop.

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