Method, device, system and apparatus for controlling liquid flow rate in microfluidic flow channel

Abstract

The present disclosure relates to a method, device, system and equipment for controlling liquid flow rate in a microfluidic channel. The method comprises: determining a target working mode corresponding to a target sensor in response to a working instruction corresponding to the target sensor; controlling a first liquid to enter a junction channel at a first flow rate and controlling a second liquid to enter the junction channel at a second flow rate according to the target working mode; the first liquid at the first flow rate and the second liquid at the second flow rate form a junction fluid in the junction channel, the first flow rate is a target flow rate corresponding to the first liquid in the target working mode, the second flow rate is a target flow rate corresponding to the second liquid in the target working mode, and a junction form of the junction fluid satisfies a junction form condition corresponding to the target working mode. The present disclosure reduces the number of valves in the flow rate control equipment and reduces the control cost of the liquid flow rate in the microfluidic channel.

Description

TECHNICAL FIELD

[0001] The present disclosure relates to the field of microfluidic technology, and particularly relates to a method, device, system and equipment for controlling liquid flow rate in a microfluidic flow channel. BACKGROUND

[0002] Microfluidic technology (Lab on a Chip) is a technology for processing or manipulating microfluids using microchannels, and is a new cross-disciplinary technology involving chemistry, fluid physics, microelectronics, new materials, biology and biomedical engineering. It has broad application prospects in the fields of medical diagnosis, biochemical analysis, chemical synthesis and environmental monitoring.

[0003] In the detection process of liquid parameters, the microfluidic flow channel needs to be cleaned before data detection. The cleaning mode and the measurement mode have different flow rate ratios of the reference liquid and the liquid to be detected. In related technologies, a valve is usually arranged at the inlet flow channel of the microfluidic flow channel, and the flow rate ratio of the reference liquid and the liquid to be detected in different working modes is controlled by adjusting the valve. This obviously increases the number of valves in the microfluidic flow channel and increases the control cost of the liquid flow rate in the microfluidic flow channel. SUMMARY

[0004] The present disclosure provides a method, device, system and equipment for controlling liquid flow rate in a microfluidic flow channel to at least solve the problem of control cost of liquid flow rate in a microfluidic flow channel in related technologies. The technical solutions of the present disclosure are as follows:

[0005] According to a first aspect of an embodiment of the present disclosure, a method for controlling liquid flow rate in a microfluidic flow channel is provided, comprising:

[0006] In response to a working instruction corresponding to a target sensor, a target working mode corresponding to the target sensor is determined. The target sensor is arranged in a junction flow channel in the microfluidic flow channel, and the microfluidic flow channel further comprises a preset inlet branch flow channel corresponding to the junction flow channel. The preset inlet branch flow channel at least comprises a first branch flow channel and a second branch flow channel. A first liquid in the first branch flow channel enters the junction flow channel through the first branch flow channel, and a second liquid in the second branch flow channel enters the junction flow channel through the second branch flow channel.

[0007] According to the target working mode, the first liquid is controlled to enter the junction flow channel at a first flow rate, and the second liquid is controlled to enter the junction flow channel at a second flow rate.

[0008] The first liquid of the first flow rate and the second liquid of the second flow rate form a confluence fluid in the confluence flow channel, the first flow rate is a target flow rate corresponding to the first liquid in the target working mode, the second flow rate is a target flow rate corresponding to the second liquid in the target working mode, and a confluence form of the confluence fluid meets a confluence form condition corresponding to the target working mode.

[0009] According to a second aspect of the embodiments of the present disclosure, a device for controlling flow rate of liquid in a microfluidic flow channel is provided, comprising:

[0010] A working mode acquisition module is configured to determine a target working mode corresponding to a target sensor in response to a working instruction corresponding to the target sensor; the target sensor is arranged in a confluence flow channel in a microfluidic flow channel; the microfluidic flow channel further comprises a preset inlet branch flow channel corresponding to the confluence flow channel; the preset inlet branch flow channel comprises at least a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the confluence flow channel through the first branch flow channel; and a second liquid in the second branch flow channel enters the confluence flow channel through the second branch flow channel.

[0011] A flow rate control module is configured to control the first liquid to enter the confluence flow channel at a first flow rate and control the second liquid to enter the confluence flow channel at a second flow rate according to the target working mode.

[0012] The first liquid of the first flow rate and the second liquid of the second flow rate form a confluence fluid in the confluence flow channel, the first flow rate is a target flow rate corresponding to the first liquid in the target working mode, the second flow rate is a target flow rate corresponding to the second liquid in the target working mode, and a confluence form of the confluence fluid meets a confluence form condition corresponding to the target working mode.

[0013] According to a third aspect of the embodiments of the present disclosure, a system for controlling flow rate of liquid in a microfluidic flow channel is provided, comprising: a microfluidic flow channel and a control device, wherein,

[0014] The microfluidic flow channel comprises a confluence flow channel and a preset inlet branch flow channel corresponding to the confluence flow channel; the preset inlet branch flow channel comprises at least a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the confluence flow channel through the first branch flow channel; a second liquid in the second branch flow channel enters the confluence flow channel through the second branch flow channel; and a target sensor is arranged in the confluence flow channel.

[0015] The control device is configured to determine a target working mode corresponding to the target sensor in response to a working instruction corresponding to the target sensor, and control the first liquid to flow into the intersection flow channel at a first flow rate and control the second liquid to flow into the intersection flow channel at a second flow rate according to the target working mode.

[0016] According to a fourth aspect of embodiments of the present disclosure, an electronic device is provided, comprising:

[0017] a processor;

[0018] a memory for storing instructions executable by the processor;

[0019] The processor is configured to execute the instructions to implement the method for controlling liquid flow rate in a microfluidic flow channel as described above.

[0020] According to a fifth aspect of embodiments of the present disclosure, a computer readable storage medium is provided, which, when instructions in the computer readable storage medium are executed by a processor of an electronic device, enables the electronic device to implement the method for controlling liquid flow rate in a microfluidic flow channel as described above.

[0021] According to a sixth aspect of embodiments of the present disclosure, a computer program product is provided, comprising a computer program, which, when executed by a processor, implements the method for controlling liquid flow rate in a microfluidic flow channel as described above.

[0022] The technical solutions provided by the embodiments of the present disclosure at least bring the following beneficial effects:

[0023] The disclosure determines the target working mode corresponding to the target sensor in response to the working instruction corresponding to the target sensor; the target sensor is arranged in a junction flow channel in a microfluidic flow channel; the microfluidic flow channel further comprises a preset inlet branch flow channel corresponding to the junction flow channel; the preset inlet branch flow channel at least comprises a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the junction flow channel through the first branch flow channel; and a second liquid in the second branch flow channel enters the junction flow channel through the second branch flow channel; according to the target working mode, the first liquid is controlled to enter the junction flow channel at a first flow rate, and the second liquid is controlled to enter the junction flow channel at a second flow rate; the disclosure can quickly determine the flow rate of the liquid in the two branch flow channels in the microfluidic flow channel according to the target working mode, so as to obtain the first flow rate of the first liquid and the second flow rate of the second liquid meeting the target working mode; and the first liquid at the first flow rate and the second liquid at the second flow rate are controlled to enter the junction flow channel, so that the first liquid at the first flow rate and the second liquid at the second flow rate form a junction fluid in the junction flow channel, and the junction form of the junction fluid meets the junction form condition corresponding to the target working mode. In the process of controlling the flow rate of the liquid in the microfluidic flow channel, the disclosure can quickly determine the liquid flow rate matched with the target working mode, avoid adjusting the liquid flow rate by the valve to meet the target working mode, thereby reducing the number of valves in the flow rate control device, and reducing the control cost of the liquid flow rate in the microfluidic flow channel.

[0024] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure. BRIEF DESCRIPTION OF DRAWINGS

[0025] The drawings incorporated into the specification and forming part of the specification, show embodiments consistent with the disclosure, and together with the specification, serve to explain the principles of the disclosure, and do not constitute undue limitation on the disclosure.

[0026] Figure 1 is a structural schematic diagram of a microfluidic flow channel liquid flow rate control system according to an exemplary embodiment.

[0027] Figure 2 is a structural schematic diagram of a microfluidic flow channel according to an exemplary embodiment.

[0028] Figure 3 is a structural schematic diagram of a microfluidic flow channel according to an exemplary embodiment.

[0029] Figure 4 is a flow chart of a microfluidic flow channel liquid flow rate control method according to an exemplary embodiment.

[0030] Figure 5is a flow chart of a first target correlation relationship determination method according to an example embodiment.

[0031] Figure 6 is a flow chart of a second correlation relationship construction method according to an example embodiment.

[0032] Figure 7 is a flow chart of a method for constructing a first correlation relationship corresponding to each of a plurality of preset microfluidic flow channels according to an example embodiment.

[0033] Figure 8 is a flow chart of another first target correlation relationship determination method according to an example embodiment.

[0034] Figure 9 is a third structural schematic diagram of a microfluidic flow channel according to an example embodiment.

[0035] Figure 10 is a schematic diagram of three working modes of a target sensor according to an example embodiment.

[0036] Figure 11 is a flow chart of a method for obtaining first measurement data of a target sensor according to an example embodiment.

[0037] Figure 12 is a structural schematic diagram of a target sensor arranged in series according to an example embodiment.

[0038] Figure 13 is a structural schematic diagram of a target sensor arranged in parallel according to an example embodiment.

[0039] Figure 14 is a block diagram of a control device for controlling the flow rate of a liquid in a microfluidic flow channel according to an example embodiment.

[0040] Figure 15 is a block diagram of an electronic device for controlling the flow rate of a liquid in a microfluidic flow channel according to an example embodiment. DETAILED DESCRIPTION

[0041] In order to make ordinary people in the art better understand the technical solutions of the present disclosure, the technical solutions in the embodiments of the present disclosure will be described clearly and completely below in conjunction with the drawings.

[0042] It should be noted that the terms "first", "second", and the like in the description and claims of the present disclosure and the above drawings are used to distinguish similar objects, and do not necessarily indicate a specific order or sequence. It should be understood that the data used in this way can be interchanged under appropriate circumstances, so that the embodiments of the disclosure described herein can be implemented in an order other than those illustrated or described herein. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present disclosure. Rather, they are merely examples of devices and methods consistent with some aspects of the present disclosure as detailed in the appended claims.

[0043] In the detection process of liquid parameters in the microfluidic flow channel, the microfluidic flow channel needs to be cleaned before data detection; the flow rate ratio of the reference liquid to the to-be-detected liquid is different in the cleaning mode and the measurement mode; in the related technology, a valve is usually arranged at the inlet flow channel of the microfluidic flow channel, and the flow rate ratio of the reference liquid to the to-be-detected liquid in different working modes is controlled by adjusting the valve, which obviously increases the number of valves in the microfluidic flow channel and increases the control cost of the liquid flow rate in the microfluidic flow channel.

[0044] In order to reduce the number of valves in the microfluidic flow channel and reduce the control cost of the liquid flow rate in the microfluidic flow channel, the present disclosure provides a control method and device for the liquid flow rate in the microfluidic flow channel and a storage medium.

[0045] Please refer to Figure 1As shown in a structural schematic diagram of a control system for liquid flow rate in a microfluidic flow channel according to an exemplary embodiment, including a control host 01, a first flow rate adjusting device 02, a second flow rate adjusting device 03, a microfluidic flow channel 04, and a target sensor 05, wherein the control host 01 can be in communication connection with the first flow rate adjusting device 02, the second flow rate adjusting device 03, and the target sensor 05, and the control host 01 can control the respective liquid flow rates of the first flow rate adjusting device 02 and the second flow rate adjusting device 03; the microfluidic flow channel 04 includes a preset inlet branch flow channel, a confluence flow channel, and an outlet flow channel connected in sequence, and the preset inlet branch flow channel can include at least a first branch flow channel and a second branch flow channel; the first flow rate adjusting device 02 and the second flow rate adjusting device 03 can include, but are not limited to, peristaltic pumps, syringe pumps, etc.; the first flow rate adjusting device 02 is used to input a first liquid into the first branch flow channel, and the second flow rate adjusting device 03 is used to input a second liquid into the second branch flow channel; the first liquid enters the confluence flow channel through the first branch flow channel, and the second liquid enters the confluence flow channel through the second branch flow channel, and the two form a confluence fluid in the confluence flow channel. The confluence flow channel can be provided with a corresponding target sensor 05, and the target sensor 05 is used to detect first measurement data of the confluence fluid in the confluence flow channel, and the target sensor 05 can be a contact or non-contact sensor relative to the confluence flow channel. In the case of a non-contact sensor, the target sensor 05 can include, but is not limited to, photoelectric sensors and other sensors; in the case of a contact sensor, the target sensor 05 can include, but is not limited to, inductive sensors, resistive sensors, piezoelectric sensors, and other sensors.

[0046] In an exemplary embodiment, when neither the first liquid nor the second liquid needs to be recovered, the outlet flow channel can be one flow channel, at which time, as shown in Figure 2 , the shape of the microfluidic flow channel 04 is Y-shaped, and the confluence fluid of the two liquids is discharged as waste liquid after entering the outlet flow channel through the confluence flow channel. In an exemplary embodiment, when the first liquid and the second liquid need to be recovered, the outlet flow channel can include a third branch flow channel and a fourth branch flow channel, wherein the third branch flow channel and the first branch flow channel are arranged on the same side of the confluence flow channel, and the fourth branch flow channel and the second branch flow channel are arranged on the other side of the confluence flow channel; at this time, as shown in Figure 3 , the shape of the microfluidic flow channel 04 is H-shaped, and the first liquid flows out of the third branch flow channel through the confluence flow channel, and the second liquid flows out of the fourth branch flow channel through the confluence flow channel. The first liquid can be a reference liquid, and the second liquid can be a to-be-measured liquid. In the application process, in the case of not needing to recover the tested blood after performing in vitro blood sampling to test parameters in the blood, the microfluidic flow channel shown in Figure 1 can be used; in the case of returning the in-vivo blood to the body after in-vitro treatment, the microfluidic flow channel shown inFigure 2 The microfluidic flow channel shown.

[0047] Figure 4 A flow chart of a method for controlling liquid flow rate in a microfluidic flow channel according to an exemplary embodiment is shown as Figure 4 The method can be applied to Figure 1 The control host 01 shown includes the following steps.

[0048] In step S401, in response to the working instruction corresponding to the target sensor, the target working mode corresponding to the target sensor is determined; the target sensor is arranged in the intersection flow channel in the microfluidic flow channel, and the microfluidic flow channel further includes a preset inlet branch flow channel corresponding to the intersection flow channel, the preset inlet branch flow channel includes at least a first branch flow channel and a second branch flow channel, a first liquid in the first branch flow channel enters the intersection flow channel through the first branch flow channel, and a second liquid in the second branch flow channel enters the intersection flow channel through the second branch flow channel.

[0049] In the embodiments of the present disclosure, the microfluidic flow channel can include an inlet flow channel, an intersection flow channel, and an outlet flow channel connected in sequence, the inlet flow channel can be a preset inlet branch flow channel corresponding to the intersection flow channel, and the preset inlet branch flow channel includes at least a first branch flow channel and a second branch flow channel; the outlet flow channel can be a flow channel, at this time, as Figure 2 The shape of the microfluidic flow channel is Y-shaped, as shown. The outlet flow channel can also include a third branch flow channel and a fourth branch flow channel, wherein the third branch flow channel and the first branch flow channel are arranged on the same side of the intersection flow channel, and the fourth branch flow channel and the second branch flow channel are arranged on the other side of the intersection flow channel; at this time, as Figure 3 The shape of the microfluidic flow channel is H-shaped, as shown. The first liquid enters the intersection flow channel through the first branch flow channel, and the second liquid enters the intersection flow channel through the second branch flow channel, and the two form an intersection fluid (laminar flow) in the intersection flow channel. The intersection flow channel can be provided with a corresponding target sensor; the working mode corresponding to the microfluidic flow channel can include multiple modes, for example, the working mode can include a start mode, a cleaning mode, a calibration mode, a measurement mode, etc.; in the cleaning mode, the microfluidic flow channel and the target sensor corresponding to the microfluidic flow channel can be cleaned; in the calibration mode, the target sensor can be calibrated; in the measurement mode, the first measurement data in the second liquid can be obtained through the target sensor; in different working modes, the flow rate ratio of the first liquid to the second liquid is different, but in special cases, two different working modes can coincide into one working mode, at this time, the flow rate ratio in the two working modes is the same; for example, the calibration mode and the cleaning mode can be set as one working mode.

[0050] In the embodiments of the present disclosure, the first liquid can be a baseline solution, and the second liquid can be a to-be-tested liquid; wherein the baseline solution (BLS) has the following characteristics:

[0051] 1. stable and known composition;

[0052] 2. flushable and capable of removing sample residues that may contaminate the target sensor;

[0053] 3. the BLS also contains the target detection object for the target sensor, and the concentration is known. The target sensor can be calibrated while being cleaned.

[0054] In the embodiments of the present disclosure, the control host can obtain a target working mode corresponding to the target sensor in response to a working instruction corresponding to the target sensor; the working instruction can carry identification information of the target working mode; the control host can also determine a next working mode corresponding to the current working mode according to the current working mode and an execution sequence of a plurality of preset working modes, and obtain the target working mode.

[0055] In the embodiments of the present disclosure, the first branch flow channel can be used to introduce the baseline solution, and the second branch flow channel can be used to introduce the to-be-tested liquid (such as blood). The baseline solution can be used to clean the intersection flow channel of the microfluidic channel. For example, when the to-be-tested liquid is blood, if there is too much to-be-tested liquid in the intersection flow channel, coagulation (such as blood clotting) may occur. At this time, the baseline solution can be used for flushing to avoid the problem of inaccurate detection data caused by liquid coagulation. When the target sensor is arranged in the intersection flow channel, the baseline solution can also be used to clean the target sensor.

[0056] In step S403, according to the target working mode, the first liquid is controlled to enter the intersection flow channel at a first flow rate, and the second liquid is controlled to enter the intersection flow channel at a second flow rate.

[0057] The first liquid at the first flow rate and the second liquid at the second flow rate form an intersection fluid in the intersection flow channel. The first flow rate is a target flow rate of the first liquid in the target working mode, and the second flow rate is a target flow rate of the second liquid in the target working mode. The intersection form of the intersection fluid satisfies an intersection form condition corresponding to the target working mode.

[0058] In the embodiments of the present disclosure, a correspondence between a plurality of working modes of a target sensor and preset flow rates can be constructed in advance to obtain a first target correlation; and a corresponding target flow rate can be determined according to a target working mode corresponding to the target sensor; in the case that the target working mode is a measurement mode, the first target correlation can be queried according to the measurement mode to obtain a preset flow rate corresponding to the target sensor in the measurement mode, and the first flow rate and the second flow rate can be obtained; in the measurement mode, the flow rate of the liquid to be measured in the confluence flow channel is usually greater than the flow rate of the reference liquid, and therefore the flow rate ratio of the two flow rates can be less than a first threshold value, which can be set according to actual conditions.

[0059] The confluence fluid can be laminar flow, and the confluence condition includes a laminar flow interface position in the measurement mode, a laminar flow interface position in the cleaning or calibration mode. The laminar flow interface position in the measurement mode includes a preset interface position associated with the coverage area of the liquid to be measured, in which the liquid to be measured in the confluence fluid can cover the detection area of the target sensor. The laminar flow interface position in the measurement mode includes a preset interface position associated with the mixing ratio of the two liquids, in which the mixing ratio of the two liquids needs to meet a preset mixing ratio range. The laminar flow interface position in the cleaning or calibration mode includes a preset interface position associated with the coverage area of the reference liquid, in which the reference liquid in the confluence fluid can cover the detection area of the target sensor.

[0060] The laminar flow interface position is related to the flow rate ratio of the two liquids, and therefore the first flow rate and the second flow rate satisfy the preset flow rate ratio corresponding to the target working mode. Alternatively, the flow rate ratio corresponding to the target working mode can be determined according to the target working mode, and then the first flow rate and the second flow rate can be determined according to at least one of the first liquid or the second liquid. For example, the target flow rate of one side is determined according to the preset flow rate ratio while the flow rate of the other side is kept unchanged, so as to obtain the first flow rate and the second flow rate; or the flow rates of both sides are adjusted to satisfy the preset flow rate ratio, so as to obtain the first flow rate and the second flow rate. Alternatively, if the liquid to be measured is blood, the adjustment rules of the blood flow rate include the principle of reducing but not increasing (to avoid excessive loss of blood), and the flow rate range limit to prevent blood clotting.

[0061] In an exemplary embodiment, as shown in Figure 5 the determination method of the first target correlation includes:

[0062] S501: obtaining the size information of the microfluidic flow channel;

[0063] In the embodiments of the present disclosure, the microfluidic flow channel can include an inlet flow channel, a junction flow channel, and an outlet flow channel. In order to ensure the effect of laminar flow in the junction flow channel, the size range of the microfluidic flow channel can be limited when the junction flow channel is a straight pipe flow channel. For example, the spatial scale feature of the flow channel has a scale range of 1 micrometer (10 -6 meters) to 1 millimeter (10 -3 meters). Table 1 is an exemplary design size (unit: um) of a microfluidic flow channel, wherein the branch flow channel includes a first branch flow channel and a second branch flow channel, and the sizes of the two flow channels are the same. After the size information is determined, the size information of the microfluidic flow channel can be obtained.

[0064] Table 1

[0065]

[0066] S503: determining a channel identifier matching the size information of the microfluidic flow channel based on a channel size association relationship, to obtain a target channel identifier; the channel size association relationship represents the corresponding relationship between the channel identifier and the size information corresponding to each of the plurality of preset microfluidic flow channels;

[0067] In the embodiments of the present disclosure, in different application scenarios, the size information corresponding to different preset microfluidic flow channels is different. The channel identifier of each preset microfluidic flow channel can be constructed, and the corresponding relationship between the channel identifier and the size information corresponding to each of the plurality of preset microfluidic flow channels can be established, to obtain the channel size association relationship. Then, according to the pre-constructed channel size association relationship, the channel identifier matching the size information of the microfluidic flow channel is determined, to obtain the target channel identifier, so as to facilitate determining the first target association relationship according to the target channel identifier.

[0068] S505: obtaining the first association relationship corresponding to each of the plurality of preset microfluidic flow channels; the first association relationship of each preset microfluidic flow channel represents the corresponding relationship between a plurality of working modes corresponding to each preset microfluidic flow channel and a plurality of preset flow rates or a plurality of preset flow rate ratios; the preset flow rate or the preset flow rate ratio corresponding to each preset microfluidic flow channel is the target liquid flow rate or the target liquid flow rate ratio of the first branch flow channel and the second branch flow channel corresponding to each preset microfluidic flow channel;

[0069] In the embodiments of the present disclosure, the first association relationship corresponding to each preset microfluidic flow channel can be pre-constructed. The first association relationship of each preset microfluidic flow channel represents the corresponding relationship between a plurality of working modes corresponding to each preset microfluidic flow channel and a plurality of preset flow rates or preset flow rate ratios. The working modes corresponding to each preset microfluidic flow channel can be the same or different, and the preset flow rate or the preset flow rate ratio corresponding to the same working mode corresponding to each preset microfluidic flow channel can be the same or different. The preset flow rate or the preset flow rate ratio corresponding to different working modes can be determined according to experimental data.

[0070] S507: Determine the first association relationship matched with the target channel identifier based on the second association relationship, and obtain the first target association relationship; the second association relationship represents the correspondence between the plurality of channel identifiers and the plurality of first association relationships.

[0071] In the embodiments of the present disclosure, the second association relationship can be constructed according to the channel identifiers of the plurality of preset microfluidic channels and the first association relationship corresponding to the plurality of preset microfluidic channels; and the first association relationship matched with the target channel identifier is searched through the second association relationship, and the first target association relationship is obtained.

[0072] In the embodiments of the present disclosure, the first association relationship corresponding to the plurality of preset microfluidic channels can be stored in advance, and the first association relationship matched with the target channel identifier of the microfluidic channel is searched through the second association relationship, so as to obtain the first target association relationship; in the case that there are a plurality of preset microfluidic channels with different sizes, the first target association relationship corresponding to the current microfluidic channel is quickly searched, and the preset flow rate or preset flow rate ratio of the target working mode corresponding to the target sensor is quickly obtained.

[0073] In the embodiments of the present disclosure, as shown in Figure 6 The method further includes a construction method of the second association relationship:

[0074] S601: Obtain the size information corresponding to each of the plurality of preset microfluidic channels;

[0075] In the embodiments of the present disclosure, in different application scenarios, the size information corresponding to different preset microfluidic channels is different.

[0076] S603: Construct the channel identifier of each preset microfluidic channel;

[0077] In the embodiments of the present disclosure, for the preset microfluidic channels with different size structures, the corresponding channel identifier can be generated, and the channel identifier can include but is not limited to characters, images and other identifiers.

[0078] S605: Construct the channel size association relationship based on the channel identifier of each preset microfluidic channel and the size information of each preset microfluidic channel;

[0079] In the embodiments of the present disclosure, the correspondence between the channel identifier of each preset microfluidic channel and the size information corresponding to each of the plurality of preset microfluidic channels can be established to obtain the channel size association relationship.

[0080] S607: According to the correspondence between the multiple working modes corresponding to each preset microfluidic flow channel and the multiple preset flow rate ratios or the multiple preset flow rates, a first association relationship corresponding to each of the multiple preset microfluidic flow channels is constructed.

[0081] In the embodiments of the present disclosure, the working modes corresponding to each preset microfluidic flow channel can be the same or different, and the preset flow rates (i.e., the first flow rate and the second flow rate) or the preset flow rate ratios (i.e., the flow rate ratios satisfied by the first flow rate and the second flow rate) corresponding to the same working mode of each preset microfluidic flow channel can be the same or different; the preset flow rates or the preset flow rate ratios corresponding to different working modes can be determined according to experimental data.

[0082] In an exemplary embodiment, as shown in FIG. 6, the first association relationship corresponding to each of the multiple preset microfluidic flow channels is constructed, including: Figure 7

[0083] S6071: Determine the multiple working modes corresponding to the screening microfluidic flow channel; the screening microfluidic flow channel is any one of the multiple preset microfluidic flow channels; the screening microfluidic flow channel includes a first screening branch flow channel and a second screening branch flow channel.

[0084] In the embodiments of the present disclosure, the first screening branch flow channel can be used to introduce a reference liquid, and the second screening branch flow channel can be used to introduce a to-be-tested liquid.

[0085] S6073: In each working mode, determine the preset flow rate ratio of the liquid in the first screening branch flow channel to the liquid in the second screening branch flow channel.

[0086] S6075: According to the preset flow rate ratio corresponding to each working mode of the screening microfluidic flow channel, a first association relationship corresponding to the screening microfluidic flow channel is constructed.

[0087] In the embodiments of the present disclosure, for each preset microfluidic flow channel, the same method as the screening microfluidic flow channel can be used to construct the corresponding first association relationship, so as to construct the first association relationship corresponding to each of the multiple preset microfluidic flow channels.

[0088] In the embodiments of the present disclosure, for any one of the multiple preset microfluidic flow channels, the preset flow rate ratio corresponding to each working mode is obtained, so as to construct the first association relationship corresponding to each preset microfluidic flow channel, facilitate the construction of the correspondence between the channel identifier and the first association relationship, obtain the second association relationship, and facilitate the query of the first association relationship corresponding to different preset microfluidic flow channels, so as to quickly determine the flow rate ratio of the microfluidic flow channel in different working modes.

[0089] ​S609: Construct the second association relationship according to the channel identifier of each preset microfluidic flow channel and the first association relationship corresponding to each preset microfluidic flow channel.

[0090] In the embodiments of the present disclosure, the channel identifier of each preset microfluidic flow channel and the first association relationship corresponding to each preset microfluidic flow channel can be obtained, the correspondence between the channel identifier and the first association relationship is constructed, and the second association relationship is obtained.

[0091] In the embodiments of the present disclosure, the channel size association relationship can be constructed according to the size information and the channel identifier corresponding to each preset microfluidic flow channel, and the first association relationship corresponding to each preset microfluidic flow channel can be constructed according to the correspondence between the multiple working modes and the multiple preset flow rate ratios corresponding to each preset microfluidic flow channel; then, the second association relationship can be constructed according to the channel identifier of each preset microfluidic flow channel and the first association relationship corresponding to each preset microfluidic flow channel; the size information of the microfluidic flow channel can be used to quickly determine the correspondence between the corresponding working mode and the preset flow rate ratio, so as to quickly determine the target flow rate ratio of the target sensor in different working modes.

[0092] In the embodiments of the present disclosure, as shown in Figure 8 the determination method of the first target association relationship includes:

[0093] S801: Determine the multiple working modes corresponding to the target sensor;

[0094] S803: Determine the flow rate ratio of the reference liquid in the first branch flow channel to the to-be-measured liquid in the second branch flow channel in each working mode, and obtain the target flow rate ratio corresponding to each working mode;

[0095] S805: Construct the first target association relationship based on the correspondence between the multiple working stages and the multiple preset flow rate ratios corresponding to the microfluidic flow channel.

[0096] In the embodiments of the present disclosure, after designing a microfluidic flow channel, the multiple working modes corresponding to the microfluidic flow channel can be determined, and the flow rate ratio of the reference liquid in the first branch flow channel to the to-be-measured liquid in the second branch flow channel in each working mode can be determined through experiments, and the target flow rate ratio corresponding to each working mode is obtained.

[0097] In an exemplary embodiment, the target flow rate ratio corresponding to each of the starting mode, the cleaning mode and the measurement mode of the target sensor can be determined; for example, the target flow rate ratio corresponding to the starting mode is 1:1, the target flow rate ratio corresponding to the cleaning mode is 3:1, and the target flow rate ratio corresponding to the measurement mode is 1:3.

[0098] In an example embodiment, a target flow rate adjusting device is installed on a target branch flow channel, the target branch flow channel being the first branch flow channel and / or the second branch flow channel; and the controlling of the first liquid to flow into the intersection flow channel at the first flow rate and the controlling of the second liquid to flow into the intersection flow channel at the second flow rate according to the target working mode comprises:

[0099] According to the target working mode, a target flow rate adjusting instruction is sent to the target flow rate adjusting device to control the first liquid to flow into the intersection flow channel at the first flow rate and the second liquid to flow into the intersection flow channel at the second flow rate.

[0100] In the embodiments of the present disclosure, the target flow rate adjusting device can be installed on the first branch flow channel and / or the second branch flow channel. In actual application, the target flow rate of the liquid in the branch flow channel on which the target flow rate adjusting device is installed can be determined according to the target flow rate ratio of the first liquid and the second liquid corresponding to the target working mode and the current flow rate of the liquid in the branch flow channel on which the target flow rate adjusting device is not installed, and the target flow rate adjusting device is used to adjust the flow rate of the liquid in the branch flow channel on which the target flow rate adjusting device is installed to the target flow rate. Alternatively, the operating parameters of the target flow rate adjusting device are directly adjusted according to the preset first flow rate and the second flow rate, so that the first liquid flows into the intersection flow channel at the first flow rate and the second liquid flows into the intersection flow channel at the second flow rate.

[0101] In the embodiments of the present disclosure, after the preset flow rate or preset flow rate ratio corresponding to each working stage of the microfluidic flow channel is determined, the first target correlation relationship can be constructed. In the embodiments of the present disclosure, the first target correlation relationship corresponding to the microfluidic flow channel can be constructed according to the preset flow rate or preset flow rate ratio corresponding to each working stage of the microfluidic flow channel, so that the first target correlation relationship can be queried according to the real-time working stage, and the flow rate ratio or flow rate of the microfluidic flow channel in different working stages can be quickly determined.

[0102] In the embodiments of the present disclosure, only one target flow rate adjusting device can be arranged in two branch flow channels of the microfluidic flow channel. In application, the flow rate of the liquid in the branch flow channel corresponding to the target flow rate adjusting device can be adjusted, and the flow rate of the liquid in the other branch flow channel is kept unchanged, so that the target flow rate ratio of the first liquid and the second liquid meets the preset condition, thereby reducing the number of flow rate adjusting devices and reducing the control cost of the flow rate of the liquid in the microfluidic flow channel.

[0103] In an example embodiment, a first flow rate adjusting device is installed on the first branch flow channel, and a second flow rate adjusting device is installed on the second branch flow channel, and the controlling of the first liquid to flow into the intersection flow channel at the first flow rate and the controlling of the second liquid to flow into the intersection flow channel at the second flow rate according to the target working mode comprises:

[0104] According to the target working mode, a first flow rate adjustment instruction is sent to the first flow rate adjustment device, so that the first liquid enters the intersection flow channel at the first flow rate;

[0105] According to the target working mode, a second flow rate adjustment instruction is sent to the second flow rate adjustment device, so that the second liquid enters the intersection flow channel at the second flow rate.

[0106] In the embodiments of the present disclosure, the target flow rate adjustment device, the first flow rate adjustment device, and the second flow rate adjustment device can include but are not limited to peristaltic pumps, syringe pumps, and the like; the first flow rate adjustment device is used to input the first liquid into the first branch flow channel, and the second flow rate adjustment device is used to input the second liquid into the second branch flow channel; after the first flow rate and the second flow rate are determined, the flow rate adjustment of the first flow rate adjustment device and the second flow rate adjustment device can be performed in an artificial adjustment mode; the flow rate adjustment of the first flow rate adjustment device and the second flow rate adjustment device can also be automatically controlled by the control host sending instructions to the first flow rate adjustment device and the second flow rate adjustment device, so that the flow rate matches the target working mode.

[0107] In the embodiments of the present disclosure, the control host can automatically adjust the flow rates of the first liquid and the second liquid by sending instructions to the first flow rate adjustment device and the second flow rate adjustment device, thereby improving the flow rate adjustment efficiency.

[0108] In the embodiments of the present disclosure, according to the target working mode, the first liquid is controlled to enter the intersection flow channel at the first flow rate, and the second liquid is controlled to enter the intersection flow channel at the second flow rate, including:

[0109] According to the target working mode, a first preset data table is searched to obtain the first flow rate corresponding to the first liquid matched with the target working mode and the second flow rate corresponding to the second liquid matched with the target working mode; the first preset data table is constructed based on a correspondence relationship between a preset working mode and a first preset flow rate of the first liquid, and a correspondence relationship between the preset working mode and a second preset flow rate of the second liquid;

[0110] The first liquid is controlled to enter the intersection flow channel at the first flow rate, and the second liquid is controlled to enter the intersection flow channel at the second flow rate.

[0111] In the embodiments of the present disclosure, the first preset data table can include a first preset flow rate of the first liquid and a second preset flow rate of the second liquid corresponding to at least one preset working mode; the first preset flow rate of the first liquid and the second preset flow rate of the second liquid in each preset working mode can be obtained; and the first preset data table can be constructed according to the first preset flow rate of the first liquid and the second preset flow rate of the second liquid in each preset working mode, so as to quickly and accurately determine the first flow rate of the first liquid and the second flow rate of the second liquid in the target working mode through the first preset data table.

[0112] In the embodiments of the present disclosure, the control of the first liquid to enter the intersection flow passage at the first flow rate and the control of the second liquid to enter the intersection flow passage at the second flow rate according to the target working mode include:

[0113] According to the target working mode, a target flow rate ratio matching the target working mode is obtained by searching the second preset data table; the target flow rate ratio is a flow rate ratio of the first liquid and the second liquid in the target working mode; the second preset data table is constructed based on a corresponding relationship between preset working modes and preset flow rate ratios; and the preset flow rate ratio is a flow rate ratio of the first liquid and the second liquid in the preset working mode.

[0114] A current detection flow rate of a first current liquid is obtained; the first current liquid is the first liquid or the second liquid;

[0115] According to the target flow rate ratio and the current detection flow rate, a target set flow rate corresponding to a second current liquid is determined; the second current liquid is a liquid other than the first current liquid among the first liquid and the second liquid;

[0116] According to the current detection flow rate and the target set flow rate, a first flow rate corresponding to the first liquid and a second flow rate corresponding to the second liquid are determined.

[0117] The first liquid is controlled to enter the intersection flow passage at the first flow rate, and the second liquid is controlled to enter the intersection flow passage at the second flow rate.

[0118] For example, a first current flow rate corresponding to the first liquid can be obtained, and the first current flow rate is determined as the first flow rate; according to the first flow rate and the target flow rate ratio, the second flow rate corresponding to the second liquid is determined. For example, a second current flow rate corresponding to the second liquid can be obtained, and the second current flow rate is determined as the second flow rate; according to the second flow rate and the target flow rate ratio, the first flow rate corresponding to the first liquid is determined.

[0119] In the embodiments of the present disclosure, the preset working modes can be at least two, and a preset flow rate ratio corresponding to the first liquid and the second liquid in each preset working mode can be determined; and a second preset data table can be constructed according to the correspondence between the preset working modes and the preset flow rate ratios; so that the target flow rate ratio matched with the target working mode can be quickly obtained by searching the second preset data table through the target working mode; and the target flow rate of the other liquid can be quickly and accurately determined according to the current flow rate of any one of the first liquid and the second liquid and the target flow rate ratio.

[0120] In the embodiments of the present disclosure, the method further comprises:

[0121] obtaining a position parameter of the interface of the intersection fluid in the target working mode; the position parameter of the interface represents the flow rate ratio of the first liquid and the second liquid in the intersection fluid; the position parameter of the interface is determined based on photosensitive information of the intersection fluid; and the photosensitive information is obtained based on a light sensor arranged at the intersection channel;

[0122] In the case that the position parameter of the interface meets a preset condition, it is determined that the intersection state of the intersection fluid meets the intersection form condition corresponding to the target working mode.

[0123] In the embodiments of the present disclosure, an image recognition device can be arranged in the intersection channel, and the position parameter of the interface of the intersection fluid in the target working mode is obtained through the image recognition device; and in the case that the position parameter of the interface meets a preset condition, it is determined that the intersection state of the intersection fluid meets the intersection form condition corresponding to the target working mode. In the case that the intersection fluid is a laminar flow liquid, if the target sensor is arranged in the intersection channel, whether the intersection state of the intersection fluid meets the intersection form condition corresponding to the target working mode can be determined through the position parameter of the interface. Different preset conditions of the position parameter of the interface corresponding to different target working modes are different; when the first liquid is a reference liquid and the second liquid is a to-be-measured liquid, in the cleaning mode, the preset condition corresponding to the position parameter of the interface can include that the position parameter of the interface is less than a preset value, at this time, the target sensor is completely covered by the reference liquid; and in the measurement mode, the preset condition corresponding to the position parameter of the interface can include that the position parameter of the interface is greater than or equal to a preset value, at this time, the target sensor is completely covered by the to-be-measured liquid.

[0124] In the embodiments of the present disclosure, whether the intersection state of the intersection fluid meets the intersection form condition corresponding to the target working mode can be determined through the position parameter of the interface; so that the intersection state of the intersection fluid can be adjusted to meet the intersection form condition corresponding to the target working mode through the position parameter of the interface; and the diversity of determining the intersection form condition in the target working mode is improved.

[0125] In the case where the interface position parameter does not meet the preset condition, the method further includes:

[0126] According to the interface position parameter and the preset condition, the first flow rate of the first liquid in the target working mode and the second flow rate of the second liquid in the target working mode are updated. The updated first flow rate and second flow rate can make the confluence form of the confluence fluid meet the confluence form condition corresponding to the target working mode.

[0127] In the case where the interface position parameter does not meet the preset condition, the first flow rate of the first liquid in the target working mode and the second flow rate of the second liquid in the target working mode can be determined according to the interface position parameter and the preset condition, and the flow rates of the two liquids are adjusted based on the flow rate determination result, so that the interface position parameter meets the preset condition.

[0128] In the case where the interface position parameter does not meet the preset condition, the first flow rate of the first liquid in the target working mode and the second flow rate of the second liquid in the target working mode can be determined according to the interface position parameter and the preset condition, and the flow rates of the two liquids are adjusted based on the flow rate determination result, so that the interface position parameter meets the preset condition.

[0129] In the measurement mode, the confluence fluid is the first confluence fluid, and the first interface position parameter of the first confluence fluid can be obtained, which represents the flow rate ratio of the to-be-measured liquid to the reference liquid in the first confluence fluid. The first interface position parameter is determined based on a first interface image corresponding to the first confluence fluid. The first interface image is obtained based on an image recognition device arranged in the confluence channel. In the case where the first interface position parameter is greater than or equal to a first preset value, it is determined that the confluence state of the first confluence fluid meets the confluence form condition corresponding to the measurement mode.

[0130] In the embodiments of the present disclosure, the image recognition device can be a photoelectric sensor, such as a camera, a charge coupled device (CCD) image sensor, a light emitting diode (LED), and the like; the first preset value can be determined according to experimental data; whether the confluence state of the first confluence fluid meets the confluence condition corresponding to the target working mode can be determined by the first interface position parameter, regardless of whether the target sensor is arranged outside or inside the confluence channel; in the case that the first confluence fluid is a laminar liquid, if the target sensor is arranged in the confluence channel, whether the target sensor is completely covered by the liquid under test can be determined by the first interface position parameter; in the case that the first interface position parameter is greater than or equal to the first preset value, it is determined that the target sensor is completely covered by the liquid under test, and at this time, the confluence state of the first confluence fluid meets the confluence condition corresponding to the target working mode.

[0131] In the embodiments of the present disclosure, in the measurement mode, whether the first confluence fluid meets the first preset condition can be determined according to the first interface position parameter of the first confluence fluid in the confluence channel; whether the acquisition condition of the detection data is met is determined, and in the case that the confluence state of the first confluence fluid meets the confluence condition corresponding to the measurement mode, the detection data of the target sensor is acquired, the first measurement data of the liquid under test is obtained, and the first measurement data of the liquid under test is quickly and accurately acquired.

[0132] In an exemplary embodiment, in the measurement mode, the method further includes:

[0133] If the confluence state of the first confluence fluid cannot meet the confluence condition corresponding to the measurement mode within the first preset period, at least one of the strategies of reducing the first flow rate of the reference liquid and increasing the second flow rate of the liquid under test is performed; the first preset period is a preset period after the reference liquid is adjusted to the first flow rate.

[0134] In the embodiments of the present disclosure, during the flow rate adjustment, the set flow rate may not be able to reach the measurement condition due to external environmental changes and the like; if the above-mentioned reference liquid is adjusted to the first preset time period after the first flow rate, the first intersection fluid cannot meet the intersection form condition corresponding to the measurement mode, which indicates that the determined first flow rate and second flow rate have certain errors, at this time, the flow rate of at least one of the reference liquid and the liquid to be measured needs to be adjusted; for example, the first flow rate of the above-mentioned reference liquid can be reduced, the first flow rate of the above-mentioned liquid to be measured can be increased, or the first flow rate of the above-mentioned reference liquid can be reduced while the first flow rate of the above-mentioned liquid to be measured is increased, so as to ensure that the intersection state of the first intersection fluid meets the intersection form condition corresponding to the measurement mode.

[0135] If the first measurement data of the liquid to be measured is the same as or similar to the preset parameter of the reference liquid within the second preset time period after the execution of the strategy, it can be determined that the first measurement data of the liquid to be measured is consistent with the preset parameter of the reference liquid.

[0136] In the embodiments of the present disclosure, if the first measurement data of the liquid to be measured is the same as or similar to the preset parameter of the reference liquid within the second preset time period after the execution of the strategy, it can be determined that the first measurement data of the liquid to be measured is consistent with the preset parameter of the reference liquid.

[0137] In the embodiments of the present disclosure, in the measurement mode, if the flow rates of the reference liquid and the liquid to be measured cannot meet the acquisition condition of the detection data all the time within a relatively long period of time, the flow rates of the reference liquid and the liquid to be measured can be adjusted again, so that the intersection state of the first intersection fluid can meet the intersection form condition corresponding to the measurement mode within a relatively short period of time, thereby improving the detection efficiency of the first measurement data; if the first measurement data of the liquid to be measured is the same as or similar to the preset parameter of the reference liquid within the second preset time period after the execution of the strategy, it can be determined that the first measurement data of the liquid to be measured is consistent with the preset parameter of the reference liquid, thereby improving the detection accuracy of the first measurement data.

[0138] In some embodiments, in the preset working mode (including the cleaning mode and the calibration mode), the intersection fluid is a second intersection fluid, and the method further includes:

[0139] obtaining a second interface position parameter of the second intersection fluid in the intersection flow channel; the second interface position parameter is determined based on a second interface image corresponding to the second intersection fluid; the second interface image is obtained based on an image recognition device arranged in the intersection flow channel; and in a case where the second interface position parameter is less than a second preset value, it is determined that the second intersection fluid meets the intersection form condition corresponding to the preset working mode.

[0140] In the embodiments of the present disclosure, the image recognition device can be a photoelectric sensor, such as a camera, a charge coupled device (CCD) image sensor, a light emitting diode (LED), and the like; the second preset value can be determined according to experimental data; whether the second intersection fluid satisfies the intersection shape condition corresponding to the preset working mode can be determined by the second interface position parameter, regardless of whether the target sensor is arranged outside or inside the intersection channel; in the case that the second intersection fluid is a laminar liquid, if the target sensor is arranged in the intersection channel, whether the target sensor is completely covered by the reference liquid can be determined by the second interface position parameter; in the case that the above-mentioned second interface position parameter is less than the second preset value, it is determined that the target sensor is completely covered by the reference liquid, and at this time, the second intersection fluid satisfies the intersection shape condition corresponding to the preset working mode.

[0141] In the embodiments of the present disclosure, in the preset working mode (including the cleaning mode and the calibration mode), whether the second intersection fluid satisfies the second preset condition can be determined according to the second interface position parameter of the second intersection fluid in the intersection channel; and whether the preset working mode is ended is determined, so that the end point of the preset working mode is automatically determined.

[0142] In the embodiments of the present disclosure, if the second intersection fluid cannot satisfy the intersection shape condition corresponding to the preset working mode within a third preset period, at least one of the following strategies is performed: increasing the target flow rate of the reference liquid, and reducing the target flow rate of the to-be-measured liquid; the third preset period is a preset period after the reference liquid is adjusted to the target flow rate.

[0143] In the embodiments of the present disclosure, during the flow rate adjustment process, the set flow rate may not meet the condition of the preset working mode due to external environmental changes and the like; if the second intersection fluid cannot satisfy the intersection shape condition corresponding to the preset working mode after the third preset period after the reference liquid is adjusted to the target flow rate, it indicates that there is an error in the determined two target flow rates, and at this time, the flow rate of at least one of the reference liquid and the to-be-measured liquid needs to be adjusted; for example, the target flow rate of the reference liquid can be increased, the target flow rate of the to-be-measured liquid can be reduced, or the target flow rate of the reference liquid can be increased while the target flow rate of the to-be-measured liquid is reduced, so as to ensure that the second intersection fluid satisfies the intersection shape condition corresponding to the preset working mode.

[0144] In some embodiments, if the end condition of the preset working mode cannot be met based on the flow rates of the reference liquid and the liquid to be measured for a relatively long period of time, the flow rates of the reference liquid and the liquid to be measured can be adjusted so that the second intersection fluid can meet the intersection shape condition corresponding to the preset working mode in a relatively short period of time.

[0145] In some embodiments, the first liquid is a reference liquid and the second liquid is a liquid to be measured, and the method further comprises:

[0146] obtaining real-time detection data of the target sensor and a preset parameter of the liquid to be measured; the preset parameter and the real-time detection data are data of the same type;

[0147] If the preset parameter matches the real-time detection data, it is determined that the intersection shape of the intersection fluid meets the intersection shape condition corresponding to the target working mode.

[0148] For example, in the measurement mode, the first detection data of the target sensor and the first preset parameter of the liquid to be measured can be obtained; if the first preset parameter matches the first detection data, it is determined that the intersection shape of the first intersection fluid meets the intersection shape condition corresponding to the measurement mode.

[0149] If the preset parameter does not match the real-time detection data, but the intersection shape of the intersection fluid meets the intersection shape condition corresponding to the target working mode, the target sensor is calibrated based on the preset parameter.

[0150] In the embodiments of the present disclosure, the target sensor can detect at least two types of data. In the measurement mode, if the first preset parameter (such as the PH value or the like) corresponding to the to-be-measured liquid is known, whether the first intersection fluid meets the intersection condition corresponding to the measurement mode can be determined according to the first detection data of the target sensor and the first preset parameter, that is, whether the acquisition opportunity of the first measurement data to be detected is met. The first detection data matches the first preset parameter means that the absolute value of the difference between the two data is equal to or less than a preset difference threshold, which can include the case that the two data are the same and the case that the difference between the two data is small. In the measurement mode, whether the first intersection fluid meets the first preset condition can be determined according to the first detection data of the target sensor and the known first preset parameter of the to-be-measured liquid, regardless of whether the target sensor is arranged inside or outside the intersection flow channel. In the case that the first intersection fluid is a laminar fluid, if the target sensor is arranged in the intersection flow channel, whether the target sensor is completely covered by the to-be-measured liquid can be determined by comparing the data. In the case that the first detection data matches the first preset parameter, it is determined that the target sensor is completely covered by the to-be-measured liquid. In the measurement process, high-frequency quasi-continuous detection can be performed, or low-frequency intermittent detection can be performed, which can be set according to actual conditions.

[0151] In the embodiments of the present disclosure, whether the first intersection fluid meets the intersection condition corresponding to the measurement mode, that is, whether the acquisition opportunity of the first measurement data to be detected is met, can be quickly determined according to the matching result of the first detection data of the target sensor and the first preset parameter of the to-be-measured liquid, so that the accuracy of the first measurement data in the to-be-measured liquid can be improved.

[0152] In some embodiments, in the preset working mode (cleaning mode or calibration mode), the second detection data of the target sensor and the second preset parameter of the reference liquid can be obtained. The second preset parameter and the second detection data are the same type of data, and the second preset parameter and the first measurement data are the same type of data. If the second detection data matches the second preset parameter, it is determined that the second intersection fluid meets the intersection condition corresponding to the preset working mode.

[0153] In the embodiments of the present disclosure, if the detected first measurement data is the parameter of the target detection object in the to-be-measured liquid, the target detection object with a known parameter can be included in the reference liquid, and the second detection data of the target sensor and the second preset parameter of the reference liquid can be obtained. The second preset parameter, the second detection data, and the first measurement data are the same type of data.

[0154] In the embodiments of the present disclosure, the second detection data of the target sensor and the second preset parameter of the target detection object in the reference liquid can be obtained; the current detection data of the target sensor corresponding to the first intersection fluid can be obtained.

[0155] The current detection data is determined as the first measurement data of the target detection object in the to-be-measured liquid.

[0156] In the embodiments of the present disclosure, if the detected first measurement data is the parameter of the target detection object in the to-be-measured liquid, the current detection data of the target sensor is determined as the first measurement data of the target detection object in the to-be-measured liquid.

[0157] In the embodiments of the present disclosure, not only the parameter of the to-be-measured liquid can be detected by the target sensor, but also the parameter of the target detection object in the to-be-measured liquid can be detected by the target sensor; the data detection range of the target sensor is expanded, and the diversity of the data type of the detection data is improved.

[0158] In the embodiments of the present disclosure, the matching of the second detection data and the second preset parameter means that the absolute value of the difference between the two data is equal to or less than a preset difference threshold, which can include the case that the two data are the same and the case that the difference between the two data is small; in the preset working mode, the target sensor can be arranged outside the intersection flow channel (non-contact type) or inside the intersection flow channel (contact type); no matter whether the target sensor is arranged outside or inside the intersection flow channel, the second intersection fluid can be determined to meet the intersection shape condition corresponding to the preset working mode according to the second detection data of the target sensor and the second preset parameter of the target detection object in the known reference liquid; in the case that the second intersection fluid is a laminar fluid, if the target sensor is arranged in the intersection flow channel, whether the target sensor is completely covered by the reference liquid can be determined by comparing the data; in the case that the second detection data matches the second preset parameter, it is determined that the target sensor is completely covered by the reference liquid, and at this time, the second intersection fluid meets the intersection shape condition corresponding to the preset working mode.

[0159] In the embodiments of the present disclosure, in the preset working mode, whether the second intersection fluid meets the intersection shape condition corresponding to the preset working mode can also be determined according to the second detection data of the target sensor and the second preset parameter of the reference liquid; whether the cleaning mode is ended can be determined, and the end point of the cleaning mode is automatically determined.

[0160] In some embodiments, the second junction fluid can also be determined to satisfy the junction condition corresponding to the preset working mode according to the second interface position parameter of the second junction fluid and the second preset parameter of the reference liquid. The second junction fluid can be determined to satisfy the junction condition corresponding to the preset working mode when the second interface position parameter is less than the second preset value and the second detection data matches the second preset parameter.

[0161] In the cleaning mode, the method further includes the following steps in the embodiments of the present disclosure:

[0162] If the second detection data matches the second preset parameter, it is determined that the cleaning mode is ended and the calibration of the target sensor is successful.

[0163] In the preset working mode, if the second detection data matches the second preset parameter, it can be determined that the calibration of the target sensor is successful. At this time, the cleaning mode can also be the calibration mode, and the target sensor can be calibrated while the flow channel and the target sensor are cleaned.

[0164] In the embodiments of the present disclosure, if the second junction fluid is determined to satisfy the second preset condition according to the second detection data of the target sensor and the second preset parameter of the reference liquid, the cleaning mode or the calibration mode can be determined, and the target sensor can be calibrated while the flow channel and the target sensor are cleaned, thereby improving the cleaning and calibration efficiency.

[0165] In the embodiments of the present disclosure, the first liquid is a reference liquid, the second liquid is a to-be-measured liquid, and when the target working mode is a measurement mode, the method of controlling the first liquid to enter the junction flow channel at a first flow rate and controlling the second liquid to enter the junction flow channel at a second flow rate according to the target working mode includes the following steps:

[0166] According to the measurement mode, the reference liquid is controlled to enter the junction flow channel at a first measurement flow rate, and the to-be-measured liquid is controlled to enter the junction flow channel at a second measurement flow rate. The first measurement flow rate is a target flow rate of the reference liquid in the measurement mode, and the second measurement flow rate is a target flow rate of the to-be-measured liquid in the measurement mode.

[0167] The method further includes the following steps:

[0168] When the region corresponding to the to-be-measured liquid in the junction flow channel covers the detection region of the target sensor, the first measurement data of the target sensor is obtained. The first measurement data is liquid detection information of the to-be-measured liquid.

[0169] In the embodiments of the present disclosure, in the case that the target working mode is a preset working mode, the preset working mode is a cleaning mode or a calibration mode, and the control of the first liquid into the intersection flow passage at the first flow rate and the control of the second liquid into the intersection flow passage at the second flow rate according to the target working mode comprises:

[0170] According to the preset working mode, the reference liquid is controlled to enter the intersection flow passage at a first initial flow rate, and the liquid to be measured is controlled to enter the intersection flow passage at a second initial flow rate; the first initial flow rate is a target flow rate corresponding to the first liquid in the preset working mode, and the second initial flow rate is a target flow rate corresponding to the second liquid in the preset working mode.

[0171] The method further comprises:

[0172] In the case that the corresponding area of the reference liquid in the intersection flow passage covers the detection area of the target sensor, the second measurement data of the target sensor is acquired.

[0173] Based on the matching result of the second measurement data and the known parameter of the reference liquid, it is determined whether the intersection form of the intersection fluid meets the intersection form condition corresponding to the preset working mode; the known parameter of the reference liquid and the liquid detection information of the liquid to be measured are parameters of the same type.

[0174] In the embodiments of the present disclosure, based on the matching result of the second measurement data and the known parameter of the reference liquid, it is determined whether the intersection form of the intersection fluid meets the intersection form condition corresponding to the target working mode, which comprises:

[0175] In the case that the second measurement data matches the known parameter of the reference liquid, it is determined that the intersection form of the intersection fluid meets the intersection form condition corresponding to the preset working mode.

[0176] The method further comprises:

[0177] The target sensor corresponding to the preset working mode is switched to a measurement mode.

[0178] In the embodiments of the present disclosure, in the case that the host determines that the cleaning mode and the calibration mode are ended, the next working mode corresponding to the cleaning mode, i.e., the measurement mode, can be determined according to the execution order of the plurality of preset working modes.

[0179] In the embodiments of the present disclosure, the measurement mode can be automatically switched to in the case that the cleaning mode is determined to be ended, so as to realize the automatic switching of each working mode of the target sensor and improve the data detection efficiency.

[0180] In an example embodiment, the target sensor can be determined to have a preset flow rate ratio corresponding to each of the start mode, the cleaning mode, and the measurement mode, so as to further determine the preset flow rate ratio of different working modes; for example, the preset flow rate and the preset flow rate ratio (such as 1:1) corresponding to the start mode, the preset flow rate and the preset flow rate ratio (such as 3:1) corresponding to the cleaning mode, and the preset flow rate and the preset flow rate ratio (such as 1:3) corresponding to the measurement mode. The preset flow rate ratio of different working modes can be used to determine the flow rates of the reference liquid and the to-be-measured liquid in each working mode; for example, as shown in Tables 2-3, Table 2 is the liquid flow rate (unit: uL / h) of the microfluidic flow channel corresponding to different working modes, and Table 3 is the liquid flow rate (unit: uL / h) when the to-be-measured liquid flow rate is not adjusted and is completely controlled by the reference liquid during the transition from the cleaning mode to the measurement mode.

[0181] Table 2

[0182] Start mode Cleaning mode Measurement mode Reference liquid 50 150 50 Liquid to be measured 50 50 150

[0183] Table 3

[0184] Start mode Cleaning mode Measurement mode Reference liquid 100 300 30 Liquid to be measured 100 100 100

[0185] In the embodiments of the present disclosure, the measurement mode also includes another mixed liquid measurement mode, the first liquid is a reaction liquid, the second liquid is a to-be-measured liquid, the content data of the target detection object in the to-be-measured liquid is detected based on a mixed liquid formed by the reaction liquid and the to-be-measured liquid, and the ratio between the first flow rate and the second flow rate is set according to the mixing ratio between the reaction liquid and the to-be-measured liquid. Optionally, the mixing ratio of the first liquid and the second liquid in the intersection fluid corresponds to a target mixing ratio, and the target mixing ratio can be used to determine the first flow rate of the first liquid and the second flow rate of the second liquid.

[0186] In the embodiments of the present disclosure, different target detection objects or liquid types or working modes can correspond to different mixing ratios (mixing ratios of the first liquid and the second liquid). Correspondingly, in the case where the target working mode is the mixed liquid measurement mode, third measurement data of the target sensor is acquired; and the content data of the target detection object, i.e., the content data in the to-be-measured liquid, is determined according to the first flow rate, the second flow rate, and the third measurement data. The first flow rate and the second flow rate can be used to determine the mixing ratio of the first liquid and the second liquid, and then the content data of the target detection object in the to-be-measured liquid is determined according to the mixing ratio and the third measurement data of the target sensor for detecting the mixed liquid.

[0187] In the case that the target detection object in the to-be-measured liquid is an anti-Xa factor, the interface needs to be kept at the middle level during measurement; that is, in the case that the converging fluid in the converging flow channel is a non-laminar fluid, the preset mixing ratio of the to-be-measured liquid and the reference liquid can be obtained, and the target flow rate ratio of the two liquids in the measurement mode is determined according to the ratio; at this time, the target flow rate ratio or the first flow rate and the second flow rate can be determined according to the preset mixing ratio required when the two liquids are mixed; for example, the preset mixing ratio of the to-be-measured liquid and the reference liquid can be determined as the target flow rate ratio of the target sensor in the measurement mode.

[0188] In the embodiments of the present disclosure, the mixing ratio of the first liquid and the second liquid can be quickly determined according to the first flow rate of the first liquid and the second flow rate of the second liquid in the target working mode; thereby the mixing ratio of the two liquids can be controlled by adjusting the flow rate ratio of the two liquids, and the content data of the target detection object in the to-be-measured liquid can be accurately determined.

[0189] In an exemplary embodiment, the first current flow rate of the reference liquid in the first branch flow channel and the second current flow rate of the to-be-measured liquid in the second branch flow channel can be obtained; the second current flow rate of the to-be-measured liquid is determined as the second flow rate of the to-be-measured liquid; and the first flow rate of the reference liquid is determined based on the first flow rate ratio, the first current flow rate and the second flow rate.

[0190] Before entering the measurement mode, the target sensor corresponds to other working modes, and the reference liquid and the to-be-measured liquid in the working modes have certain flow rates; at this time, the first current flow rate of the reference liquid in the first branch flow channel and the second current flow rate of the to-be-measured liquid in the second branch flow channel can be obtained; the second current flow rate can be judged, and if the value meets the preset condition, for example, when the second current flow rate belongs to the preset flow rate range, the second current flow rate of the to-be-measured liquid is determined as the second flow rate of the to-be-measured liquid; and then the first flow rate of the reference liquid is calculated according to the first flow rate ratio, the first current flow rate and the second flow rate. At this time, only the flow rate of the reference liquid in the first branch flow channel can be adjusted. In the embodiments of the present disclosure, after entering the measurement mode, only the flow rate of the reference liquid can be adjusted, and the flow rate of the to-be-measured liquid is not adjusted, thereby reducing the complexity of flow rate adjustment and improving the working efficiency. Moreover, when the to-be-measured liquid is blood, blood loss can be reduced.

[0191] In an exemplary embodiment, the first liquid is a reaction liquid, and the second liquid is a to-be-measured liquid, and the method further comprises:

[0192] In the case that the target working mode is the measurement mode, if the target detection object in the to-be-measured liquid is anti-Xa factor, a mixing ratio of the reaction liquid and the to-be-measured liquid is obtained.

[0193] Based on the mixing ratio of the reaction liquid and the to-be-measured liquid, a target flow rate ratio of the reaction liquid and the to-be-measured liquid in the measurement mode is determined.

[0194] In the embodiments of the present disclosure, the intersection flow channel can include a first intersection flow channel and a second intersection flow channel, the first intersection flow channel is a bent pipe structure, the second intersection flow channel is a straight pipe structure, the to-be-measured liquid and the reaction liquid form a mixed liquid in the first intersection flow channel, and the mixed liquid can be a liquid after the to-be-measured liquid and the reaction liquid react, at this time, the reaction liquid and the to-be-measured liquid have reacted chemically, and the mixed liquid forms the first intersection flow in the second intersection flow channel; the microfluidic flow channel can further include a liquid inlet flow channel for cutting the liquid, the liquid inlet flow channel can include a liquid inlet and two liquid inlet branch flow channels in communication with the liquid inlet, the cutting liquid enters the two liquid inlet branch flow channels through the liquid inlet, the outlets of the two liquid inlet branch flow channels are in communication with the second intersection flow channel, and in the second intersection flow channel, the cutting liquid cuts the mixed liquid into droplets, and then the target sensor detects the first measurement data of the droplets to obtain the first measurement data of the to-be-measured liquid.

[0195] In the embodiments of the present disclosure, when the intersection flow in the intersection flow channel is the mixed liquid, the target flow rate ratio corresponding to the measurement mode can be determined according to the mixing ratio of the reaction liquid and the to-be-measured liquid, so as to flexibly adjust the target flow rate ratio according to the application scenario.

[0196] In an example embodiment, as shown in Figure 9 Figure 9 ​It is a structural schematic diagram of a microfluidic flow channel. The microfluidic flow channel includes a first branch flow channel 041, a second branch flow channel 042, a confluence flow channel, and a liquid inlet flow channel for cutting liquid. The first branch flow channel 041 is used for inputting reference liquid, and the second branch flow channel 042 is used for inputting liquid to be measured. The confluence flow channel includes a first confluence flow channel 043 and a second confluence flow channel 044. A corresponding target sensor 05 is arranged outside the second confluence flow channel 044. The first confluence flow channel 043 is a bent pipe structure, and the second confluence flow channel 044 is a straight pipe structure. The reference liquid and the liquid to be measured are mixed to form a mixed liquid in the first confluence flow channel 043 and enter the second confluence flow channel 044. The liquid inlet flow channel can include a liquid inlet 045 and two liquid inlet branch flow channels 046 and 047 in communication with the liquid inlet. The cutting liquid enters the two liquid inlet branch flow channels through the liquid inlet. The outlets of the two liquid inlet branch flow channels are in communication with the second confluence flow channel. In the second confluence flow channel, the cutting liquid can cut the mixed liquid into droplets. The target sensor 05 can be an optical sensor. The first measurement data of the liquid to be measured is obtained by detecting the droplets through the sensor. If the liquid to be measured is blood, since it is real-time monitoring, the extracted blood will not flow back to the human body, so the principle of adjusting the blood flow rate can be the principle of adjusting small instead of large, thereby avoiding excessive blood loss. In order to maintain the effect of laminar flow, a flow rate adjustment range can also be provided. In order to keep the blood from clotting, a blood flow rate adjustment range can also be provided separately. The adjustment of the flow rate can be implemented within the above limits.

[0197] In an exemplary embodiment, as shown in Figure 10 , Figure 10 It is a schematic diagram of three working modes corresponding to a target sensor. The microfluidic flow channel is in an H-shaped structure. The microfluidic flow channel includes an inlet flow channel, a confluence flow channel, and an outlet flow channel connected in sequence. The inlet flow channel includes a first branch flow channel 041 and a second branch flow channel 042. The first branch flow channel 041 is used for inputting reference liquid, and the second branch flow channel 042 is used for inputting liquid to be measured. The confluence flow channel can be provided with a corresponding target sensor 05. The target sensor 05 is used for detecting the first measurement data of the confluence fluid in the confluence flow channel. In Figure 10 , a diagram a is a schematic diagram of an initial working mode corresponding to a microfluidic flow channel. The flow rates of the reference liquid and the liquid to be measured are the same, both being 50 uL / h. Figure 10 , a diagram b is a schematic diagram of a cleaning mode corresponding to a microfluidic flow channel. The flow rate ratio of the reference liquid to the liquid to be measured is 3:1. Figure 10FIG. 10 is a schematic diagram of a measurement mode corresponding to the microfluidic flow channel, wherein the flow rate ratio of the reference liquid to the to-be-measured liquid is 1:3; when it is necessary to continuously detect the first measurement data of the to-be-measured liquid for multiple times, the cleaning mode and the measurement mode can be switched periodically, and the flow channel and the target sensor can be cleaned periodically during the data measurement process, so as to improve the accuracy of the first measurement data.

[0198] In the embodiments of the present disclosure, at least two target sensors can be arranged in the intersection flow channel, and the at least two target sensors are arranged in series. Figure 11 As shown in FIG. 10, when the to-be-measured liquid covers the detection area of the target sensor in the corresponding area in the intersection flow channel, the first measurement data of the target sensor is obtained, including:

[0199] S1101: When the to-be-measured liquid covers the detection area of the at least two target sensors in the corresponding area in the intersection flow channel, the current detection data corresponding to each of the at least two target sensors is obtained.

[0200] S1103: The first measurement data is determined according to each of the current detection data.

[0201] In the embodiments of the present disclosure, a plurality of target sensors can be arranged in series in the intersection flow channel or outside the intersection flow channel, and the plurality of target sensors can detect the same type of data or different types of data. When the to-be-measured liquid covers the detection area of the at least two target sensors in the corresponding area in the intersection flow channel, the current detection data corresponding to each of the at least two target sensors is obtained, so that the first measurement data is determined according to each of the current detection data.

[0202] In the embodiments of the present disclosure, if the plurality of target sensors detect the same type of data, the accuracy of the first measurement data can be improved; if the plurality of target sensors detect different types of data, the diversity of the first measurement data can be improved.

[0203] In an exemplary embodiment, the first measurement data is determined according to each of the current detection data, including:

[0204] In the case where each target sensor is used to detect different types of data, the first measurement data is determined according to the sum of each of the current detection data.

[0205] In the case where each target sensor is used to detect the same type of data, each of the current detection data is determined as the first measurement data.

[0206] In this embodiment of the disclosure, multiple target sensors can be arranged in series in or outside the confluence channel. The multiple target sensors can detect the same type of data or different types of data. When each target sensor is used to detect different types of data, the first measurement data can be obtained by calculating the average value of each of the above-mentioned current detection data. When each target sensor is used to detect the same type of data, each of the above-mentioned current detection data is determined as the first measurement data.

[0207] In this embodiment of the disclosure, multiple target sensors are connected in series, and each of the multiple target sensors is correspondingly arranged with respect to the converging flow channel. The method further includes:

[0208] Obtain the device type corresponding to each target sensor;

[0209] Based on the device type corresponding to each target sensor, the arrangement position of each target sensor relative to the aforementioned converging flow channels is determined.

[0210] In this embodiment, multiple target sensors can be arranged in series in or outside the confluence channel. These sensors can detect the same type of data or different types of data. If the multiple target sensors are of different device types, their arrangement relative to the confluence channel can be pre-set. Device types can include contact and non-contact types, with contact-type target sensors positioned in front of non-contact-type target sensors. That is, contact-type target sensors are positioned near the inlet of the confluence channel, and non-contact-type target sensors are positioned near the outlet. For example, purely optical target sensors can be placed in front because they do not contact the analyte and therefore do not alter its composition. Contact-type target sensors, even though their effect on the analyte is minimal, should be placed behind to minimize their impact on the components in the liquid being measured.

[0211] In one exemplary embodiment, such as Figure 12 As shown, Figure 12 This is a schematic diagram of a target sensor array; target sensors 051 and 052 are arrayed and installed inside or outside the converging flow channel. The arrangement of the two target sensors can be determined according to their device types.

[0212] In this embodiment of the disclosure, when multiple target sensors are connected in series, the arrangement position of each target sensor relative to the aforementioned converging flow channel can be determined according to the device type corresponding to the multiple target sensors, thereby avoiding the target sensor arranged in front from affecting the detection result of the target sensor arranged behind, and improving the accuracy of the detection results of multiple target sensors.

[0213] In the embodiments of the present disclosure, the microfluidic flow channel includes a first liquid inlet flow channel, a second liquid inlet flow channel, and at least two intersection flow channels, the at least two intersection flow channels are arranged in parallel; at least one target sensor is arranged in each intersection flow channel; each intersection flow channel corresponds to a group of preset inlet branch flow channels; each group of preset inlet branch flow channels includes the first branch flow channel and the second branch flow channel, the first liquid is distributed to each first branch flow channel through the first liquid inlet flow channel; the second liquid is distributed to each second branch flow channel through the second liquid inlet flow channel; in the case that the target working mode is a measurement mode, in the case that the corresponding region of the to-be-measured liquid in each intersection flow channel covers the detection region of the target sensor corresponding to each intersection flow channel, the first measurement data of the target sensor is obtained, including:

[0214] In the case that the corresponding region of the to-be-measured liquid in each intersection flow channel covers the detection region of the target sensor corresponding to each intersection flow channel, the current detection data of the target sensor corresponding to each of the at least two intersection flow channels is obtained;

[0215] According to each of the current detection data, the first measurement data is determined.

[0216] In an exemplary embodiment, according to each of the current detection data, the first measurement data is determined, including:

[0217] In the case that the target sensor corresponding to each intersection flow channel is used to detect the same type of data, the first measurement data is determined according to the sum of each of the current detection data;

[0218] In the case that the target sensor corresponding to each intersection flow channel is used to detect different types of data, each of the current detection data is determined as the first measurement data.

[0219] In the embodiments of the present disclosure, the target number of target sensors can be obtained; based on the target number, the number of intersection flow channels in the microfluidic flow channel is determined; the number of intersection flow channels can be an odd number or an even number; based on the number of intersection flow channels, the structure of the microfluidic flow channel is determined; based on the structure of the microfluidic flow channel, the target sensor corresponding to each intersection flow channel is determined. The number of intersection flow channels can be greater than or equal to the target number according to the target number of target sensors.

[0220] In the embodiments of the present disclosure, the plurality of target sensors can be arranged in parallel, at this time, a plurality of intersection flow channels are required to be arranged, each of which corresponds to at least one target sensor; the arrangement of the plurality of target sensors requires that the flow rate of each flow channel is the same; therefore, the number of intersection flow channels can be determined according to the target number of target sensors, and the number of intersection flow channels can be greater than or equal to the target number; after determining the number of intersection flow channels, the structure of the microfluidic flow channel can be determined; compared with the series mode, the parallel measurement can maximize the exclusion of upstream pollution interference, and can avoid the mutual influence between the target sensors.

[0221] In the embodiments of the present disclosure, compared with the series mode, the parallel mode can avoid the mutual influence between the target sensors, so as to improve the accuracy of the detection results of each target sensor.

[0222] In some embodiments, based on the number of intersection flow channels, the structure of the microfluidic flow channel is determined, including:

[0223] If the number of intersection flow channels is two, the two intersection flow channels are arranged side by side in the microfluidic flow channel, the first branch flow channel corresponding to each of the two intersection flow channels corresponds to the first inlet flow channel, the second branch flow channel corresponding to each of the two intersection flow channels corresponds to the second inlet flow channel, and the first inlet flow channel and the second inlet flow channel are two branches of the inlet flow channel of the microfluidic flow channel.

[0224] In the embodiments of the present disclosure, if the number of intersection flow channels is two, the first branch flow channel corresponding to each of the two intersection flow channels can be arranged corresponding to the first inlet flow channel, the second branch flow channel corresponding to each of the two intersection flow channels can be arranged corresponding to the second inlet flow channel, the first inlet flow channel and the second inlet flow channel are two branches of the inlet flow channel of the microfluidic flow channel, and the two intersection flow channels are arranged side by side.

[0225] In the embodiments of the present disclosure, if the number of intersection flow channels is two, the two intersection flow channels can be arranged side by side, so as to realize the side-by-side arrangement of the plurality of target sensors and reduce the influence between the detection results of the plurality of target sensors.

[0226] In some embodiments, based on the number of intersection flow channels, the structure of the microfluidic flow channel is determined, including:

[0227] If the number of intersection flow channels is greater than two, a plurality of intersection flow channel groups are obtained by grouping the plurality of intersection flow channels; each intersection flow channel group includes two intersection flow channels;

[0228] The plurality of intersection flow channel groups are sorted to obtain a sorting result.

[0229] Based on the above sorting result, determine the initial intersection channel group connected with the inlet channel of the microfluidic flow channel;

[0230] Take the initial intersection channel group as the current intersection channel group, and determine the two current intersection channels in the current intersection channel group;

[0231] Determine the current remaining channel group corresponding to each of the two current intersection channels in the current intersection channel group; the current remaining channel group is the intersection channel group whose arrangement position is not determined at present;

[0232] Determine that the outlet of each current intersection channel is in communication with the inlet of the two current remaining channels in the current remaining channel group corresponding to each current intersection channel; the two current remaining channels in the current remaining channel group are arranged side by side;

[0233] Take each current remaining channel in the current remaining channel group as a current intersection channel group in turn, and repeat the steps of determining the current remaining channel group corresponding to each of the two current intersection channels in the current intersection channel group and determining that the outlet of each current intersection channel is in communication with the inlet of the two current remaining channels in the current remaining channel group corresponding to each current intersection channel until there is no current remaining channel group.

[0234] In the embodiments of the present disclosure, regarding the shunt design, in order to maintain synchronization, only two divisions are made, that is, there will be no three-way intersection or more branches; the two division designs are usually 1:2, 2:4, and 4:8. A plurality of intersection channels can be sorted randomly or according to a preset rule to obtain a sorting result, based on the sorting result, the intersection channel group at the first (or last) position in the sorting can be taken as the initial intersection channel group; then, the intersection channel group at the second and third positions in the sorting (or the intersection channel group at the second to last and third to last positions in the sorting) is taken as the current remaining channel group corresponding to each of the two current intersection channels in the current intersection channel group; and the arrangement positions of all intersection channel groups are determined in turn. In an exemplary embodiment, as shown in Figure 13 , Figure 13 is a structural schematic diagram of a target sensor arranged in parallel; the target sensors 051 and 052 are arranged in the two intersection channels arranged in parallel.

[0235] In the embodiments of the present disclosure, when the number of interaction channels is more than two even numbers, regarding the structure of the microfluidic flow channel, two division design can be performed, which can effectively ensure that the flow rates of each branch channel are the same, and can reduce complexity and increase universality.

[0236] In an exemplary embodiment, the method further comprises:

[0237] If the multiple current detection data are of the same type, determine an average of the multiple current detection data;

[0238] In an example embodiment, if the multiple current detection data are of the same type, determining an average of the multiple current detection data includes:

[0239] If the multiple current detection data are of the same type, determine whether there is abnormal data in the multiple current detection data; the absolute value of the difference between the abnormal data and each non-abnormal data is greater than a preset value, and the non-abnormal data is data other than the abnormal data in the multiple current detection data;

[0240] If there is no abnormal data in the multiple current detection data, determine an average of the multiple current detection data.

[0241] In the embodiments of the present disclosure, whether the target sensors are connected in parallel or in series, the detection data of the multiple target sensors can be of the same type. At this time, whether there is abnormal data can be determined according to the multiple current detection data. The abnormal data is data that is greatly different from other current detection data. If there is no abnormal data, an average of the multiple current detection data is directly calculated to obtain the first measurement data.

[0242] In the embodiments of the present disclosure, if the multiple current detection data are of the same type, whether there is abnormal data can be determined according to the multiple current detection data. When there is no abnormal data, an average of the multiple current detection data is directly calculated to obtain the first measurement data, thereby improving the accuracy of the first measurement data.

[0243] In an example embodiment, if there is abnormal data in the multiple current detection data, the method further includes:

[0244] Determine an average of the non-abnormal data in the multiple current detection data;

[0245] Determine the average of the non-abnormal data as the first measurement data of the to-be-measured liquid.

[0246] In the embodiments of the present disclosure, if the multiple current detection data are of the same type and there is abnormal data in the multiple current detection data, the average of the non-abnormal data can be calculated after the abnormal data is excluded to obtain the first measurement data of the to-be-measured liquid.

[0247] In the embodiments of the present disclosure, if the multiple current detection data are of the same type and there is abnormal data in the multiple current detection data, the first measurement data of the to-be-measured liquid is calculated according to the non-abnormal data, thereby improving the accuracy of the first measurement data.

[0248] In an example embodiment, if the abnormal data exists in the plurality of current detection data, the method further comprises:

[0249] determining the target sensor corresponding to the abnormal data as a faulty device.

[0250] In the embodiments of the present disclosure, if the abnormal data exists in the plurality of current detection data, the target sensor corresponding to the abnormal data can be directly determined as a faulty device, and the faulty device can be excluded in the subsequent working mode.

[0251] In the embodiments of the present disclosure, the target sensor corresponding to the abnormal data can be determined as a faulty device, and the plurality of target sensors can be calibrated.

[0252] determining the average value of the plurality of current detection data as the first measurement data of the to-be-measured liquid.

[0253] In the embodiments of the present disclosure, if the plurality of target sensors detect the same type of data, the average value can be calculated according to the current detection data corresponding to each of the plurality of target sensors, and the first measurement data of the to-be-measured liquid can be obtained.

[0254] In the embodiments of the present disclosure, if the plurality of target sensors detect the same type of data, the average value can be calculated, and the accuracy of the first measurement data of the to-be-measured liquid can be improved.

[0255] In the embodiments of the present disclosure, the device determines a target working mode corresponding to a target sensor in response to a working instruction corresponding to the target sensor; the target sensor is arranged in a confluence flow channel in a microfluidic flow channel; the microfluidic flow channel further includes a preset inlet branch flow channel corresponding to the confluence flow channel; the preset inlet branch flow channel includes at least a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the confluence flow channel through the first branch flow channel; and a second liquid in the second branch flow channel enters the confluence flow channel through the second branch flow channel; according to the target working mode, the first liquid is controlled to enter the confluence flow channel at a first flow rate, and the second liquid is controlled to enter the confluence flow channel at a second flow rate; the present disclosure can quickly determine the flow rates of the liquids in the two branch flow channels in the microfluidic flow channel according to the target working mode, so as to obtain the first flow rate of the first liquid and the second flow rate of the second liquid that meet the target working mode; and the first liquid at the first flow rate and the second liquid at the second flow rate are controlled to enter the confluence flow channel, so that the confluence fluid formed by the first liquid at the first flow rate and the second liquid at the second flow rate in the confluence flow channel meets the confluence form condition corresponding to the target working mode. In the process of controlling the flow rate of the liquid in the microfluidic flow channel, the present disclosure can quickly determine the liquid flow rate matched with the target working mode, avoid adjusting the liquid flow rate by a valve to meet the target working mode, thereby reducing the number of valves in the flow rate control device and reducing the control cost of the liquid flow rate in the microfluidic flow channel.

[0256] Figure 14 FIG. 1 is a block diagram of a device for controlling the flow rate of a liquid in a microfluidic flow channel according to an example embodiment. Referring to FIG. 1, Figure 14 the device includes:

[0257] a working mode acquisition module 1410 configured to determine a target working mode corresponding to a target sensor in response to a working instruction corresponding to the target sensor; the target sensor is arranged in a confluence flow channel in a microfluidic flow channel; the microfluidic flow channel further includes a preset inlet branch flow channel corresponding to the confluence flow channel; the preset inlet branch flow channel includes at least a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the confluence flow channel through the first branch flow channel; and a second liquid in the second branch flow channel enters the confluence flow channel through the second branch flow channel;

[0258] a flow rate control module 1420 configured to control the first liquid to enter the confluence flow channel at a first flow rate and control the second liquid to enter the confluence flow channel at a second flow rate according to the target working mode;

[0259] The first liquid of the first flow rate and the second liquid of the second flow rate form a confluence fluid in the confluence flow channel, the first flow rate is a target flow rate corresponding to the first liquid in the target working mode, the second flow rate is a target flow rate corresponding to the second liquid in the target working mode, and a confluence form of the confluence fluid satisfies a confluence form condition corresponding to the target working mode.

[0260] In an example embodiment, the first liquid is a reference liquid, the second liquid is a to-be-measured liquid, and when the target working mode is a measurement mode, the flow rate control module comprises:

[0261] a first flow rate control unit configured to control the reference liquid to enter the confluence flow channel at a first measurement flow rate and control the to-be-measured liquid to enter the confluence flow channel at a second measurement flow rate according to the measurement mode; the first measurement flow rate is a target flow rate corresponding to the reference liquid in the measurement mode, and the second measurement flow rate is a target flow rate corresponding to the to-be-measured liquid in the measurement mode.

[0262] In an example embodiment, the device further comprises:

[0263] a first measurement data acquisition module configured to acquire first measurement data of the target sensor when a region corresponding to the to-be-measured liquid in the confluence flow channel covers a detection region of the target sensor; the first measurement data is liquid detection information of the to-be-measured liquid.

[0264] In an example embodiment, when the target working mode is a preset working mode, the preset working mode is a cleaning mode or a calibration mode, and the flow rate control module comprises:

[0265] a second flow rate control unit configured to control the reference liquid to enter the confluence flow channel at a first initial flow rate and control the to-be-measured liquid to enter the confluence flow channel at a second initial flow rate according to the preset working mode; the first initial flow rate is a target flow rate corresponding to the first liquid in the preset working mode, and the second initial flow rate is a target flow rate corresponding to the second liquid in the preset working mode.

[0266] In an example embodiment, the device further comprises:

[0267] a second measurement data acquisition module configured to acquire second measurement data of the target sensor when a region corresponding to the reference liquid in the confluence flow channel covers a detection region of the target sensor.

[0268] The intersection condition determining module is configured to determine whether the intersection form of the intersection fluid satisfies the intersection form condition corresponding to the preset working mode based on a matching result of the second measurement data and the known parameter of the reference liquid; and the known parameter of the reference liquid and the liquid detection information of the to-be-detected liquid are parameters of the same type.

[0269] In an example embodiment, the intersection condition determining module comprises:

[0270] The intersection condition determining unit is configured to determine that the intersection form of the intersection fluid satisfies the intersection form condition corresponding to the preset working mode in a case where the second measurement data matches the known parameter of the reference liquid.

[0271] In an example embodiment, the device further comprises:

[0272] The mode switching module is configured to switch the preset working mode corresponding to the target sensor to a measurement mode.

[0273] In an example embodiment, the first liquid is a reaction liquid, the second liquid is a to-be-detected liquid, the content data of a target detection object in the to-be-detected liquid is detected based on a mixed liquid formed by the reaction liquid and the to-be-detected liquid, and the ratio between the first flow rate and the second flow rate is set according to a mixing ratio between the reaction liquid and the to-be-detected liquid. The device further comprises:

[0274] The first measurement data obtaining module is configured to obtain third measurement data of the target sensor in a case where the target working mode is a mixed liquid measurement mode.

[0275] The content determining module is configured to determine the content data of the target detection object according to the first flow rate, the second flow rate, and the third measurement data.

[0276] The device further comprises:

[0277] The mixing ratio obtaining module is configured to obtain a mixing ratio of the reaction liquid and the to-be-detected liquid in a case where the target working mode is a measurement mode and the target detection object in the to-be-detected liquid is an anti-Xa factor.

[0278] The target flow rate ratio determining module is configured to determine a target flow rate ratio of the reaction liquid and the to-be-detected liquid in the measurement mode based on the mixing ratio of the reaction liquid and the to-be-detected liquid.

[0279] In an example embodiment, a flow rate adjusting device is installed on the target branch flow channel, and the target branch flow channel is the first branch flow channel and / or the second branch flow channel. The flow rate control module comprises:

[0280] a target instruction sending unit configured to send a target flow rate adjustment instruction to the flow rate adjustment device according to the target working mode, so as to control the first liquid to flow into the confluence flow passage at the first flow rate and control the second liquid to flow into the confluence flow passage at the second flow rate.

[0281] In an example embodiment, the first branch flow passage is provided with a first flow rate adjustment device, and the second branch flow passage is provided with a second flow rate adjustment device. The flow rate control module comprises:

[0282] a first instruction sending unit configured to send a first flow rate adjustment instruction to the first flow rate adjustment device according to the target working mode, so as to control the first liquid to flow into the confluence flow passage at the first flow rate;

[0283] a second instruction sending unit configured to send a second flow rate adjustment instruction to the second flow rate adjustment device according to the target working mode, so as to control the second liquid to flow into the confluence flow passage at the second flow rate.

[0284] In an example embodiment, the device further comprises:

[0285] a boundary position parameter acquisition module configured to acquire a boundary position parameter of the confluence fluid under the target working mode; the boundary position parameter represents a flow rate ratio of the first liquid to the second liquid in the confluence fluid; the boundary position parameter is determined based on photosensitive information of the confluence fluid; and the photosensitive information is acquired based on a light sensor arranged at the confluence flow passage;

[0286] a confluence form condition determination module configured to determine that a confluence state of the confluence fluid meets a confluence form condition corresponding to the target working mode when the boundary position parameter meets a preset condition.

[0287] In an example embodiment, when the boundary position parameter does not meet the preset condition, the device further comprises:

[0288] a flow rate determination module configured to update the first flow rate of the first liquid under the target working mode and the second flow rate of the second liquid under the target working mode according to the boundary position parameter and the preset condition.

[0289] In an example embodiment, at least two target sensors are arranged in the confluence flow passage in a series arrangement. The device further comprises:

[0290] In an example embodiment, the first measurement data acquisition module comprises:

[0291] a first current detection data acquisition unit, configured to acquire respective current detection data of the at least two target sensors in a case where the corresponding region of the to-be-measured liquid in the intersection flow channel covers the detection region of the at least two target sensors;

[0292] a first determination unit, configured to determine the first measurement data according to the respective current detection data.

[0293] In an exemplary embodiment, the microfluidic flow channel comprises a first liquid inlet flow channel, a second liquid inlet flow channel, and at least two intersection flow channels arranged in parallel; at least one target sensor is arranged in each intersection flow channel; each intersection flow channel corresponds to a group of preset inlet branch flow channels; each group of preset inlet branch flow channels comprises the first branch flow channel and the second branch flow channel; the first liquid is distributed to each first branch flow channel through the first liquid inlet flow channel; the second liquid is distributed to each second branch flow channel through the second liquid inlet flow channel; in a case where the target working mode is a measurement mode, the above first measurement data acquisition module comprises:

[0294] a second current detection data acquisition unit, configured to acquire current detection data of the target sensor corresponding to each intersection flow channel in a case where the corresponding region of the to-be-measured liquid in each intersection flow channel covers the detection region of the target sensor corresponding to each intersection flow channel;

[0295] a second determination unit, configured to determine the first measurement data according to the respective current detection data.

[0296] The device in the above device embodiment and the method embodiment are based on the same inventive concept.

[0297] The embodiment also provides a control system for liquid flow rate in a microfluidic flow channel, comprising a microfluidic flow channel and a control device, wherein,

[0298] The above microfluidic flow channel comprises an intersection flow channel and a preset inlet branch flow channel corresponding to the intersection flow channel; the preset inlet branch flow channel comprises at least a first branch flow channel and a second branch flow channel; the first liquid in the first branch flow channel enters the intersection flow channel through the first branch flow channel; the second liquid in the second branch flow channel enters the intersection flow channel through the second branch flow channel; and a target sensor is arranged in the intersection flow channel.

[0299] The control device is configured to determine a target operation mode corresponding to the target sensor in response to an operation instruction corresponding to the target sensor, and control the first liquid to flow into the intersection flow channel at a first flow rate and control the second liquid to flow into the intersection flow channel at a second flow rate according to the target operation mode.

[0300] Optionally, the fluid control device comprises the flow adjusting device. The fluid control device is configured to perform the control method mentioned in the above embodiments. The microfluidic flow channel and the control device can be applied in an extracorporeal blood circulation system, such as a mechanical auxiliary circulation system corresponding to an artificial heart or an artificial lung (ECMO). The second branch flow channel can be in communication with an extracorporeal blood circulation loop, and the second liquid can be blood, so that real-time blood monitoring can be realized in the microfluidic flow channel, and blood parameters can be dynamically and continuously detected without manual blood sampling detection, thereby improving the convenience of blood monitoring.

[0301] Figure 15 is a block diagram of an electronic device for controlling the flow rate of a liquid in a microfluidic flow channel according to an example embodiment. The electronic device can be a terminal, and its internal structure can be as shown in Figure 15 The electronic device includes a processor, a memory, a network interface, a display screen, and an input device connected through a system bus. The processor of the electronic device is configured to provide computing and control capabilities. The memory of the electronic device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operating system and the computer program in the non-volatile storage medium to run. The network interface of the electronic device is configured to communicate with external terminals through network connections. The computer program is executed by the processor to implement a control method for the flow rate of a liquid in a microfluidic flow channel. The display screen of the electronic device can be a liquid crystal display screen or an electronic ink display screen. The input device of the electronic device can be a touch layer overlaid on the display screen, or a key, trackball, or touchpad provided on the shell of the electronic device, or an external keyboard, touchpad, or mouse, etc.

[0302] Those skilled in the art can understand that Figure 15 the structure shown in the above is only a block diagram of part of the structure related to the present disclosure, and does not constitute a limitation on the electronic device to which the present disclosure is applied. The specific electronic device can include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0303] In an example embodiment, an electronic device is also provided, comprising:

[0304] The processor; a memory for storing the above-mentioned processor-executable instructions; wherein the above-mentioned processor is configured to execute the above-mentioned instructions to realize the above-mentioned control method of liquid flow rate in the microfluidic flow channel.

[0305] In an exemplary embodiment, a computer readable storage medium including instructions, such as a memory including instructions, is also provided, which can be executed by a processor of an electronic device to complete the above-mentioned control method of liquid flow rate in the microfluidic flow channel. Optionally, the computer readable storage medium can be a ROM, a random access memory (RAM), a CD-ROM, a magnetic tape, a floppy disk, and an optical data storage device, etc.

[0306] In an exemplary embodiment, a computer program product including a computer program is also provided, which is executed by a processor to realize the above-mentioned control method of liquid flow rate in the microfluidic flow channel.

[0307] The present disclosure determines a target working mode corresponding to a target sensor in response to a working instruction corresponding to the target sensor; the target sensor is arranged in a junction flow channel in a microfluidic flow channel; the microfluidic flow channel further includes a preset inlet branch flow channel corresponding to the junction flow channel; the preset inlet branch flow channel includes at least a first branch flow channel and a second branch flow channel; a first liquid in the first branch flow channel enters the junction flow channel through the first branch flow channel; and a second liquid in the second branch flow channel enters the junction flow channel through the second branch flow channel; according to the target working mode, the first liquid is controlled to enter the junction flow channel at a first flow rate, and the second liquid is controlled to enter the junction flow channel at a second flow rate; the present disclosure can quickly determine the flow rates of the liquids in the two branch flow channels in the microfluidic flow channel according to the target working mode, so as to obtain the first flow rate of the first liquid and the second flow rate of the second liquid that meet the target working mode; and the first liquid at the first flow rate and the second liquid at the second flow rate are controlled to enter the junction flow channel, so that the junction fluid formed by the first liquid at the first flow rate and the second liquid at the second flow rate in the junction flow channel meets the junction shape condition corresponding to the target working mode. In the process of controlling the liquid flow rate in the microfluidic flow channel, the present disclosure can quickly determine the liquid flow rate matched with the target working mode, avoid adjusting the liquid flow rate by a valve to meet the target working mode, thereby reducing the number of valves in the flow rate control device and reducing the control cost of the liquid flow rate in the microfluidic flow channel.

[0308] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer readable storage medium. When the computer program is executed, the processes of the above-mentioned embodiments of the methods can be included. Any reference to memory, storage, databases, or other media in this application can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration but not limitation, RAM is available in many forms such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0309] Other embodiments of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure disclosed herein. This application is intended to cover any variations, uses, or adaptations of the disclosure that are deemed to fall within the general principles of the disclosure and include commonly known or customary practice in the art. The specification and examples are to be considered exemplary only, with the true scope and spirit of the disclosure being indicated by the following claims.

[0310] It should be understood that the present disclosure is not limited to the precise structures as herein described and illustrated in the drawings, and that various modifications and changes can be made without departing from the scope thereof. The scope of the present disclosure is limited only by the claims that follow.

Claims

1. A method for controlling the liquid flow rate in a microfluidic channel, characterized in that, The method includes: In response to the working command corresponding to the target sensor, the target working mode corresponding to the target sensor is determined; the target sensor is disposed in the confluence channel in the microfluidic channel, and the microfluidic channel further includes a preset inlet branch channel corresponding to the confluence channel. The preset inlet branch channel includes at least a first branch channel and a second branch channel. The first liquid in the first branch channel enters the confluence channel through the first branch channel, and the second liquid in the second branch channel enters the confluence channel through the second branch channel. According to the target operating mode, the first liquid is controlled to enter the confluence channel at a first flow rate, and the second liquid is controlled to enter the confluence channel at a second flow rate; Wherein, the first liquid at the first flow rate and the second liquid at the second flow rate form a converging fluid in the converging channel, the first flow rate is the target flow rate of the first liquid under the target working mode, the second flow rate is the target flow rate of the second liquid under the target working mode, and the converging pattern of the converging fluid satisfies the converging pattern condition corresponding to the target working mode.

2. The method according to claim 1, characterized in that, The first liquid is a reference liquid, and the second liquid is the liquid to be tested. When the target operating mode is a measurement mode, controlling the first liquid to enter the confluence channel at a first flow rate and controlling the second liquid to enter the confluence channel at a second flow rate, according to the target operating mode, includes: According to the measurement mode, the reference liquid is controlled to enter the confluence channel at a first measurement flow rate, and the test liquid is controlled to enter the confluence channel at a second measurement flow rate; the first measurement flow rate is the target flow rate corresponding to the reference liquid in the measurement mode, and the second measurement flow rate is the target flow rate corresponding to the test liquid in the measurement mode; The method further includes: When the area of ​​the liquid to be tested in the confluence channel covers the detection area of ​​the target sensor, the first measurement data of the target sensor is acquired; the first measurement data is the liquid detection information of the liquid to be tested.

3. The method according to claim 2, characterized in that, When the target operating mode is a preset operating mode, which is a cleaning mode or a calibration mode, the step of controlling the first liquid to enter the confluence channel at a first flow rate and controlling the second liquid to enter the confluence channel at a second flow rate according to the target operating mode includes: According to the preset working mode, the reference liquid is controlled to enter the confluence channel at a first initial flow rate, and the test liquid is controlled to enter the confluence channel at a second initial flow rate; the first initial flow rate is the target flow rate of the first liquid in the preset working mode, and the second initial flow rate is the target flow rate of the second liquid in the preset working mode. The method further includes: When the reference liquid covers the detection area of ​​the target sensor in the corresponding area of ​​the confluence channel, the second measurement data of the target sensor is acquired; Based on the matching result between the second measurement data and the known parameters of the reference liquid, it is determined whether the confluence pattern of the confluence fluids meets the confluence pattern conditions corresponding to the preset working mode; the known parameters of the reference liquid and the liquid detection information of the liquid to be tested are parameters of the same type.

4. The method according to claim 3, characterized in that, The step of determining whether the confluence pattern of the confluence fluids satisfies the confluence pattern conditions corresponding to the preset working mode, based on the matching result of the second measurement data and the known parameters of the reference liquid, includes: If the second measurement data matches the known parameters of the reference liquid, it is determined that the confluence pattern of the confluence fluids satisfies the confluence pattern conditions corresponding to the preset working mode; The method further includes: Switch the preset working mode corresponding to the target sensor to the measurement mode.

5. The method according to claim 1, characterized in that, The first liquid is a reaction liquid, and the second liquid is a test liquid. The content data of the target analyte in the test liquid is detected based on the mixture formed by the reaction liquid and the test liquid. The ratio between the first flow rate and the second flow rate is set according to the mixing ratio between the reaction liquid and the test liquid. The method further includes: When the target operating mode is the mixture measurement mode, the third measurement data of the target sensor is acquired; The content data of the target analyte are determined based on the first flow rate, the second flow rate, and the third measurement data.

6. The method according to claim 1, characterized in that, A flow rate regulating device is installed on the target branch channel, which is the first branch channel and / or the second branch channel; the step of controlling the first liquid to enter the confluence channel at a first flow rate and controlling the second liquid to enter the confluence channel at a second flow rate according to the target operating mode includes: According to the target operating mode, a target flow rate adjustment command is sent to the flow rate adjustment device to control the first liquid to enter the confluence channel at the first flow rate and to control the second liquid to enter the confluence channel at the second flow rate.

7. The method according to claim 1, characterized in that, The method further includes: The interface position parameters of the confluence fluids in the target operating mode are obtained; the interface position parameters characterize the flow velocity ratio of the first liquid and the second liquid in the confluence fluids; the interface position parameters are determined based on the photosensitive information of the confluence fluids; the photosensitive information is obtained based on the photosensitive sensor installed at the confluence channel; If the interface position parameters meet the preset conditions, the confluence pattern of the confluence fluids is determined to satisfy the confluence pattern conditions corresponding to the target working mode.

8. The method according to claim 7, characterized in that, If the interface position parameter does not meet the preset conditions, the method further includes: Based on the interface position parameters and the preset conditions, update the first flow rate of the first liquid and the second flow rate of the second liquid in the target working mode.

9. The method according to claim 2, characterized in that, At least two target sensors are disposed in the confluence channel, and the at least two target sensors are arranged in series; when the area of ​​the liquid to be tested in the confluence channel covers the detection area of ​​the target sensor, the first measurement data of the target sensor is acquired, including: When the area of ​​the liquid to be tested in the confluence channel covers the detection area of ​​the at least two target sensors, the current detection data corresponding to each of the at least two target sensors is acquired; The first measurement data is determined based on each of the current detection data.

10. The method according to claim 2, characterized in that, The microfluidic channel includes a first liquid inlet channel, a second liquid inlet channel, and at least two confluence channels, wherein the at least two confluence channels are arranged in parallel; at least one target sensor is disposed in each confluence channel; wherein each confluence channel corresponds to a set of preset inlet branch channels; each set of preset inlet branch channels includes a first branch channel and a second branch channel, wherein the first liquid is diverted to each of the first branch channels via the first liquid inlet channel; and the second liquid is diverted to each of the second branch channels via the second liquid inlet channel; when the target working mode is a measurement mode, when the area of ​​the liquid to be measured in the confluence channel covers the detection area of ​​the target sensor, the first measurement data of the target sensor is acquired, including: When the area of ​​the liquid to be tested in each confluence channel covers the detection area of ​​the target sensor corresponding to each confluence channel, the current detection data of the target sensor corresponding to each of the at least two confluence channels is acquired. The first measurement data is determined based on each of the current detection data.

11. A device for controlling the flow rate of liquid in a microfluidic channel, characterized in that, The device includes: The working mode acquisition module is used to determine the target working mode corresponding to the target sensor in response to the working command corresponding to the target sensor; the target sensor is disposed in the confluence channel in the microfluidic channel, and the microfluidic channel further includes a preset inlet branch channel corresponding to the confluence channel. The preset inlet branch channel includes at least a first branch channel and a second branch channel. The first liquid in the first branch channel enters the confluence channel through the first branch channel, and the second liquid in the second branch channel enters the confluence channel through the second branch channel. A flow rate control module is used to control the first liquid to enter the confluence channel at a first flow rate and to control the second liquid to enter the confluence channel at a second flow rate, according to the target operating mode. Wherein, the first liquid at the first flow rate and the second liquid at the second flow rate form a converging fluid in the converging channel, the first flow rate is the target flow rate of the first liquid under the target working mode, the second flow rate is the target flow rate of the second liquid under the target working mode, and the converging pattern of the converging fluid satisfies the converging pattern condition corresponding to the target working mode.

12. A control system for liquid flow rate in a microfluidic channel, characterized in that, include: Microfluidic channels and control devices, wherein, The microfluidic channel includes a confluence channel and a preset inlet branch channel corresponding to the confluence channel. The preset inlet branch channel includes at least a first branch channel and a second branch channel. A first liquid in the first branch channel enters the confluence channel through the first branch channel, and a second liquid in the second branch channel enters the confluence channel through the second branch channel. A target sensor is provided in the confluence channel. The control device is the device described in claim 11.

13. An electronic device, characterized in that, include: processor; Memory used to store the processor's executable instructions; The processor is configured to execute the instructions to implement the control method as described in any one of claims 1-10.

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