Microfluidic chip

Abstract

The application provides a microfluidic chip, and belongs to the technical field of microfluidics. In view of the problems of low mixing uniformity and mixing efficiency of the microfluidic chip, which leads to low qualified rate and production efficiency of prepared nanoparticles, the application provides a microfluidic chip, which comprises a chip body, a flow channel is arranged on the chip body, and the flow channel comprises a liquid inlet part and a mixing part; the liquid inlet part comprises two liquid inlet sections for respectively introducing two types of fluids; the mixing part comprises a flow guiding section, a flow guiding section and a flow mixing section which are sequentially connected, the flow guiding section comprises a lower flow converging area and an upper flow converging area, the inlet of the flow guiding section is connected with the flow guiding section and is arranged opposite to the lower flow converging area; the outlet of the flow guiding section is connected with the flow mixing section and is arranged opposite to the upper flow converging area; the inlet and the outlet of the flow guiding section are arranged opposite to each other, and the lower end of the outlet of the flow guiding section corresponds to the space between the lower flow converging area and the upper flow converging area. The application can improve the mixing uniformity and efficiency, thereby improving the qualified rate and production efficiency of the prepared nanoparticles.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of microfluidic technology, in particular to a microfluidic chip. BACKGROUND

[0002] Based on the delivery carrier of nanoscale, namely nanoparticles, is one of the core technical barriers of many molecular drugs, and the delivery carrier is responsible for protecting and allowing the drug molecules to be effectively absorbed by the body through various body cell barriers. At present, the preparation methods of nanoparticles mainly include high-pressure homogenization method, nanoparticle precipitation method, material self-assembly, in-situ synthesis / polymerization method, etc. However, the nanoparticles prepared by these methods have non-uniform structure, wide particle size distribution, complex synthesis steps and large batch-to-batch difference, which to a great extent limits their use in the preparation of delivery materials. In contrast, the use of microfluidic mixing technology to prepare nanoparticles shows obvious advantages.

[0003] Microfluidics refers to the manipulation of liquids on a sub-millimeter scale, wherein the sub-millimeter scale is generally several micrometers to several hundred micrometers. The use of this method to prepare nanoparticles is relatively simple and fast, the conditions are controllable, and the repeatability is strong. Microfluidic chip is a commonly used tool for microfluidic technology, and the preparation of nanoparticles using a microfluidic chip generally includes the following steps:

[0004] 1. Adding multiple component fluids for preparing nanoparticles into the microfluidic chip;

[0005] 2. Mixing and dispersing the multiple component fluids in the microfluidic chip to form a precursor mixture;

[0006] 3. Under specific conditions, the precursor mixture is gradually converted into nanoparticles through the mixing and dispersing action in the microfluidic chip.

[0007] However, the flow channel size of the existing microfluidic chip is usually in the micro-nano scale, and the fluid Reynolds number (Re) of the micro-nano scale is small, usually less than 2500, and the viscous force of the fluid is dominant, and the flow is in a laminar flow state. At this time, the traditional turbulent mixing between two fluids will not occur, that is, the fluids are not easy to mix, that is, the mixing uniformity is poor, resulting in a large difference in the particle size of the prepared nanoparticles, and the pressure is greatly compressed after high flow rate, which is prone to leakage and other situations during production, and it is difficult to scale up production.

[0008] There are corresponding improvements in the prior art for the above problems, for example, a fishbone type microfluidic chip, which sets multiple fishbone type barriers in the mixing flow channel to increase the contact area between fluids, thereby enhancing mixing; for example, a Y type microfluidic chip, which sets two entering flow channels in front of the mixing flow channel, and the three are in Y type, to enhance the flowability of each component, thereby enhancing mixing; for example, a combination type microfluidic chip of Y type and fishbone type. However, the above existing microfluidic chips still do not meet the requirements of mixing uniformity and low efficiency in the preparation of nanoparticles, and cannot complete linear scale-up production. SUMMARY

[0009] The purpose of the present application is to solve the problem of low mixing uniformity and mixing efficiency of microfluidic chips in the prior art, which leads to low pass rate and production efficiency of prepared nanoparticles. Therefore, the present application provides a microfluidic chip, which improves mixing uniformity and efficiency through the flow guiding section of the mixing part, thereby improving the pass rate and production efficiency of nanoparticle preparation.

[0010] The present application provides a microfluidic chip, which comprises a chip body, a flow channel is arranged on the chip body, the flow channel comprises a liquid inlet part, and a plurality of mixing parts which are sequentially connected and communicated with the liquid inlet part;

[0011] The liquid inlet part comprises two liquid inlet sections to respectively introduce two types of fluids;

[0012] The mixing part comprises a flow guiding section, a flow guiding section and a flow mixing section which are sequentially connected and communicated, the flow guiding section comprises a lower layer confluence zone and an upper layer confluence zone, the inlet of the flow guiding section is connected with the flow guiding section, and is oppositely arranged with the lower layer confluence zone; the outlet of the flow guiding section is connected with the flow mixing section, and is oppositely arranged with the upper layer confluence zone;

[0013] The inlet and outlet of the flow guiding section are oppositely arranged, and the lower end of the outlet of the flow guiding section corresponds to the space between the lower layer confluence zone and the upper layer confluence zone.

[0014] The above technical scheme is adopted, the lower layer flow collection area and the upper layer flow collection area of the flow guide section and the inlet and the outlet of the flow guide section correspond to the lower layer flow collection area and the upper layer flow collection area respectively, so that the fluid in the flow guide section is hindered, that is, the lower end of the outlet of the flow guide section, and bypasses the hindrance, so that the vortex can be formed; at the same time, since the two types of fluid to be mixed flow in a laminar flow state, the fluid on one side is collected in the lower layer flow collection area, and the fluid on the other side is collected in the upper layer flow collection area, and the fluid in the lower layer flow collection area is more susceptible to the hindrance of the lower end of the outlet of the flow guide section, so that when the fluid in the lower layer flow collection area is collected to a certain extent, the fluid enters the mixed flow section through the lower end of the outlet of the flow guide section and forms a vortex, while the fluid in the upper layer flow collection area is collected to a certain extent, enters the mixed flow section from the upper end of the outlet of the flow guide section, and is attracted and wrapped by the vortex, so that the mixing uniformity and the mixing efficiency are improved, and then the qualified rate of nanoparticle preparation and the production efficiency are improved.

[0015] In some embodiments, the flow guide section further comprises a flow guide channel arranged between the lower layer flow collection area and the upper layer flow collection area, and the fluid passes through the flow guide channel and then passes through the lower end of the outlet of the flow guide section and enters the mixed flow section.

[0016] The above technical scheme is adopted, the flow guide channel is provided between the lower layer flow collection area and the upper layer flow collection area to provide a space for the fluid in the flow guide section to flow and pass through the lower end of the outlet of the flow guide section, so that the vortex is formed in the mixed flow section behind, the vortex forming effect is improved, the mixing uniformity and the mixing efficiency are improved, and then the qualified rate of nanoparticle preparation and the production efficiency are improved.

[0017] In some embodiments, the flow guide section is arc-shaped and is formed with an outer channel and an inner channel, the inlet of the outer channel is arranged opposite to the lower layer flow collection area, and the inlet of the inner channel is arranged opposite to the flow guide channel.

[0018] The above technical scheme is adopted, the two types of fluid in a laminar flow state can flow through the outer channel and the inner channel respectively, and since the fluid in the outer channel flows faster and the lower layer flow collection area is opposite to the inlet of the outer channel, the fluid in the outer channel enters and collects in the lower layer flow collection area more quickly; and the fluid in the inner channel flows slower, when it reaches the inlet of the inner channel, due to the extrusion of the fluid in the lower layer flow collection area, especially the fluid in the lower layer flow collection area occupies the second half of the flow guide channel (the fluid in the lower layer flow collection area passes through the second half of the flow guide channel and then passes through the lower end of the outlet of the flow guide section), so that the fluid in the inner channel enters the upper layer flow collection area through the first half of the flow guide channel; that is, the flow rate difference of the two types of fluid is achieved, the collection effect of the two types of fluid in the lower layer flow collection area and the upper layer flow collection area is improved, and then the mixing uniformity and the mixing efficiency of the two types of fluid in the mixed flow section are improved.

[0019] In some embodiments, the mixed flow section is arc-shaped and is centrally symmetric to the flow guide section; the mixed flow section is formed with a vortex area corresponding to the outlet of the flow guide channel, and an upper area of the vortex area is oppositely arranged to the upper layer confluence area.

[0020] The above technical solution enables the fluid in the upper layer confluence area to enter the vortex area after entering the mixed flow section from the upper end of the outlet of the flow guide section, so as to be attracted and wrapped by the vortex, thereby further improving the mixing uniformity and mixing efficiency, and improving the qualified rate of nanoparticle preparation and production efficiency.

[0021] In some embodiments, at least one group of two adjacent mixing sections is provided with an acceleration section between the mixing sections, and the inner wall of the channel of the acceleration section is smoothly transitioned; the inlet of the acceleration section is connected to the outlet of the mixed flow section of one mixing section, and the outlet of the acceleration section is connected to the inlet of the flow guide section of another mixing section.

[0022] The above technical solution enables the mixed fluid to be further mixed in the acceleration section, and provides a buffer for the next mixing in the mixing section, and at the same time, the average flow rate of the fluid in the flow channel is high through the acceleration section, thereby improving the nanoparticle production efficiency.

[0023] In some embodiments, the acceleration section is curve-shaped and has at least one inflection point; and the acceleration section and the two mixing sections connected thereto are vertically arranged.

[0024] The above technical solution enables the fluid inside and outside the acceleration section to have a flow rate difference through the curve-shaped acceleration section, and at the same time, the direction and flow rate of the fluid inside and outside the acceleration section are adjusted through the acceleration section having at least one inflection point, thereby improving the mixing uniformity and mixing efficiency of the fluid in the acceleration section; and the mixing sections and the acceleration section are vertically arranged, thereby improving the smoothness of the fluid in the mixing section entering the acceleration section, and further improving the mixing uniformity and mixing efficiency of the fluid in the acceleration section.

[0025] In some embodiments, at least one group of two adjacent mixing sections is provided with both the acceleration section and a high-speed section between the mixing sections; the inlet of the high-speed section is communicated with the outlet of the mixed flow section of one mixing section, and the outlet of the high-speed section is communicated with the mixed flow section of another mixing section.

[0026] The above technical solution enables part of the fluid to pass through the high-speed section at high speed by avoiding the high-speed section of the mixing section, thereby improving the average flow rate of the fluid in the flow channel and improving the nanoparticle production efficiency; and the outlet of the high-speed section is communicated with the mixed flow section of the mixing section, so that the high-speed fluid flowing out of the high-speed section can impact the fluid in the mixed flow section, thereby mixing the two parts of fluid and improving the mixing uniformity of the fluid.

[0027] In some embodiments, the acceleration section and the high-speed section are further arranged between the liquid inlet section and the mixing section, and the inlet of the acceleration section arranged between the liquid inlet section and the mixing section is communicated with the outlet of the liquid inlet section, and the outlet is communicated with the inlet of the flow guiding section of the mixing section; the inlet of the high-speed section arranged between the liquid inlet section and the mixing section is communicated with the outlet of the liquid inlet section, and the outlet is communicated with the mixed flow section of the mixing section.

[0028] In some embodiments, the liquid inlet section is symmetrically provided with two buffer cavities near the end thereof.

[0029] Other features and corresponding advantages of the present application will be described in the following part of the specification, and it should be understood that at least some of the advantages are apparent from the description of the present application in the specification. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 Fig. 1 is a structural schematic diagram of a flow channel in a microfluidic chip according to the present application;

[0031] Figure 2 Fig. 2 is an enlarged structural schematic diagram of a mixing section of a flow channel according to the present application;

[0032] Figure 3 Fig. 3 is a structural schematic diagram of a flow channel in a microfluidic chip according to the present application, wherein the flow channel comprises a high-speed section;

[0033] Figure 4 Fig. 4 is a partial structural schematic diagram of a microfluidic chip according to the present application.

[0034] Reference signs: 1, flow channel; 2, chip body;

[0035] 10, liquid inlet section; 11, liquid inlet section; 111, buffer cavity; 12, flow converging section;

[0036] 20, mixing section; 21, flow guiding section; 211, outer channel; 212, inner channel; 22, flow guiding section; 221, lower flow converging area; 222, flow guiding channel; 223, upper flow converging area; 23, mixed flow section; 231, vortex area;

[0037] 30, acceleration section;

[0038] 40, high-speed section;

[0039] 50, liquid outlet section. DETAILED DESCRIPTION

[0040] The following will describe the embodiments of the present application by specific examples, and those skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in the specification. Although the description of the present application will be introduced in combination with the preferred embodiments, it does not mean that the features of the present application are limited to the embodiments. On the contrary, the purpose of introducing the present application in combination with the embodiments is to cover other alternatives or modifications which can be extended based on the claims of the present application. In order to provide a deep understanding of the present application, many specific details will be included in the following description. The present application can also be implemented without using these details. In addition, in order to avoid confusion or obscure the present application, some specific details will be omitted in the description. It should be noted that the embodiments and features in the embodiments of the present application can be combined with each other without conflict.

[0041] It should be noted that in the specification, similar reference numbers and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0042] The technical solutions of the present application will be described in detail below in combination with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0043] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined with "first", "second", etc. can explicitly or implicitly include one or more features. In the description of the present application, unless otherwise stated, the meaning of "a plurality of" is two or more.

[0044] In the description of the present application, it should be noted that unless specifically defined and limited otherwise, the terms "mounting", "connection", "linking" should be understood in a broad sense, for example, it can be fixed connection, or detachable connection, or integral connection; it can be mechanical connection, or electrical connection; it can be direct connection, or indirect connection through intermediate medium, or internal connection of two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0045] In order to make the purpose, technical scheme and advantages of the present application more clear, the embodiments of the present application will be further described in detail below with reference to the drawings.

[0046] Please refer to Figure 1 、 Figure 2 and Figure 4 , Figure 1 is a schematic view of the structure of the flow channel 1 in the microfluidic chip of the present application; Figure 2 is an enlarged schematic view of the mixing part 20 of the flow channel 1 of the present application; Figure 4 is a schematic view of the partial structure of the microfluidic chip of the present application.

[0047] The embodiment of the present application provides a microfluidic chip, which comprises a chip body 2, wherein the chip body 2 is provided with a flow channel 1, and the flow channel 1 comprises a liquid inlet part 10 and a plurality of mixing parts 20 which are sequentially connected and communicated with the liquid inlet part 10.

[0048] In one embodiment, the flow channel 1 further comprises a liquid outlet part 50 for outputting the mixed fluid. The liquid outlet part 50 is located at the end of the flow channel 1, and the plurality of mixing parts 20 are arranged between the liquid inlet part 10 and the liquid outlet part 50.

[0049] In one embodiment, the liquid inlet part 10 comprises two liquid inlet sections 11 for respectively introducing two types of fluid. Preferably, the two liquid inlet sections 11 are arranged in a v shape to improve the controllability of liquid inlet and the final mixing effect.

[0050] In one embodiment, the liquid inlet part 10 further comprises a confluence section 12 arranged at the end of the two liquid inlet sections 11, wherein the confluence section 12 is in a straight line shape or a curve shape with a plurality of inflection points, so as to improve the preliminary mixing effect of the fluid; at the same time, the confluence section 12 in a straight line shape can also improve the efficiency of the fluid entering the mixing part, thereby improving the mixing efficiency; and the confluence section 12 in a curve shape with a plurality of inflection points can further improve the preliminary mixing effect of the fluid.

[0051] It should be noted that the inflection point refers to the point of changing the direction of the curve upward or downward. For example, the confluence section 12 has three inflection points.

[0052] In one embodiment, the liquid inlet section 11 is symmetrically provided with two buffer cavities 111 near its end, so as to reduce the flow rate of the two types of fluids before they are mixed, improve the mixing control, and thus improve the subsequent mixing uniformity and mixing efficiency. Preferably, the two symmetrically arranged buffer cavities 111 are in the shape of a swallow.

[0053] In one embodiment, the mixing section 20 comprises a flow guiding section 21, a flow guiding section 22 and a flow mixing section 23 connected in sequence.

[0054] The flow guiding section 22 comprises a lower flow converging area 221 and an upper flow converging area 223. The inlet of the flow guiding section 22 is connected to the flow guiding section 21 and is arranged opposite to the lower flow converging area 221. The outlet of the flow guiding section 22 is connected to the flow mixing section 23 and is arranged opposite to the upper flow converging area 223. The inlet of the flow guiding section 22 is arranged opposite to the outlet, and the lower end of the outlet of the flow guiding section 22 corresponds to the position between the lower flow converging area 221 and the upper flow converging area 223.

[0055] That is, the lower flow converging area 221 and the upper flow converging area 223 of the flow guiding section 22, as well as the inlet and the outlet of the flow guiding section 22, correspond to the lower flow converging area 221 and the upper flow converging area 223, respectively, so that the fluid in the flow guiding section 22 is hindered at the lower end of the outlet of the flow guiding section 22, and bypasses the hindrance, thereby forming a vortex, for example, a Karman vortex street effect is formed on one side of the hindrance to form a vortex. At the same time, the fluid entering one side of the flow guiding section 22 can be collected in the lower flow converging area 221, and the fluid entering the other side can be collected in the upper flow converging area 223. The fluid in the lower flow converging area 221 is more susceptible to the hindrance at the lower end of the outlet of the flow guiding section 22, so that when the fluid in the lower flow converging area 221 is collected to a certain extent, it enters the flow mixing section 23 through the lower end of the outlet of the flow guiding section 22 and forms a vortex. When the fluid in the upper flow converging area 223 is collected to a certain extent, it enters the flow mixing section 23 through the upper end of the outlet of the flow guiding section 22 and is attracted and wrapped by the vortex, thereby improving the mixing uniformity and the mixing efficiency, and thus improving the qualified rate of the nanoparticles and the production efficiency. That is, the nanoparticles produced by using the microfluidic chip have uniform size, controllable particle size, high repeatability, and extremely low pressure under high flow rate, and can be linearly scaled up for production.

[0056] It should be noted that the two types of fluids are not fully mixed in the front section of the flow channel 1, and the two types of fluids are more obviously distinguished near the two liquid inlet sections 11. As the fluid flows to the end of the flow channel 1, the distinction becomes more and more blurred after passing through multiple mixing sections 20, and finally the two types of fluids are fully mixed.

[0057] In one embodiment, the flow guide section 22 further comprises a flow guide channel 222 arranged between the lower flow confluence area 221 and the upper flow confluence area 223, and the fluid flows through the flow guide channel 222 and then over the lower end of the outlet of the flow guide section 22 and enters the mixed flow section 23, i.e. a space is provided between the lower flow confluence area 221 and the upper flow confluence area 223 for the fluid in the flow guide section 22 to flow and over the lower end of the outlet of the flow guide section 22, so as to form a vortex in the rear mixed flow section 23, thereby improving the vortex forming effect, and thus improving the mixing uniformity and mixing efficiency, and further improving the qualified rate of nanoparticle preparation and production efficiency.

[0058] In one embodiment, the flow guide section 21 is arc-shaped and is formed with an outer channel 211 and an inner channel 212, the inlet of the outer channel 211 is arranged opposite to the lower flow confluence area 221, and the inlet of the inner channel 212 is arranged opposite to the flow guide channel 222, so that the two types of fluid in laminar flow can spontaneously flow through the outer channel 211 and the inner channel 212, respectively. Due to the faster flow rate of the fluid in the outer channel 211, and the lower flow confluence area 221 opposite to the inlet of the outer channel 211, the fluid in the outer channel 211 enters and gathers in the lower flow confluence area 221 more quickly. The flow rate of the fluid in the inner channel 212 is slower, and when it reaches the inlet of the inner channel 212, it enters the upper flow confluence area through the front half of the flow guide channel 222 due to the extrusion of the fluid in the lower flow confluence area 221, especially the fluid in the lower flow confluence area 221 occupying the rear half of the flow guide channel 222 (the fluid in the lower flow confluence area 221 passes through the rear half of the flow guide channel 222 and over the lower end of the outlet of the flow guide section 22). That is, the flow rate difference between the two types of fluid is achieved, the gathering effect of the two types of fluid in the lower flow confluence area 221 and the upper flow confluence area 223 is improved, and thus the mixing uniformity and mixing efficiency in the mixed flow section 23 are improved.

[0059] It should be noted that the outer channel 211 formed by the arc-shaped flow guide section 21 refers to the portion far from the center, and the inner channel 212 refers to the portion close to the center.

[0060] In one embodiment, the mixed flow section 23 is arc-shaped and is arranged in a central symmetry with the flow guide section 21. The mixed flow section 23 is formed with a vortex area 231 corresponding to the outlet of the flow guide channel 222, and the upper area of the vortex area 231 is arranged opposite to the upper flow confluence area 223, so that the fluid in the upper flow confluence area 223 enters the vortex area 231 after entering the mixed flow section 23 from the upper end of the outlet of the flow guide section 22, and is attracted and wrapped by the vortex, thereby further improving the mixing uniformity and mixing efficiency, and improving the qualified rate of nanoparticle preparation and production efficiency.

[0061] In one embodiment, at least one set of two adjacent mixing sections 20 is provided with an acceleration section 30, the inner wall of the channel of the acceleration section 30 is smoothly transitioned; the inlet of the acceleration section 30 is connected with the outlet of the mixed flow section 23 of one mixing section 20, and the outlet of the acceleration section 30 is connected with the inlet of the flow guide section 21 of another mixing section 20, so that the mixed fluid can be further mixed in the acceleration section 30, and provide buffer for the next mixing by the mixing section 20, at the same time, the average flow rate of the fluid in the flow channel 1 can be higher through the acceleration section 30, thereby improving the production efficiency of nanoparticles.

[0062] In one embodiment, the acceleration section 30 and the mixing section 20 are alternately arranged, so that the fluid in the flow channel can be continuously replaced in the mixed flow and acceleration state, thereby improving the mixing uniformity and mixing efficiency.

[0063] In one embodiment, the acceleration section 30 is in a curved shape, so that the fluid in the acceleration section 30 has a flow rate difference between the inside and the outside, and has at least one inflection point, so that the direction and flow rate of the fluid in the acceleration section 30 are reversed, thereby improving the mixing uniformity and mixing efficiency of the fluid in the acceleration section 30.

[0064] In one embodiment, the acceleration section 30 and the two mixing sections 20 connected therewith are vertically arranged, which can improve the smoothness of the fluid in the mixing section 20 entering the acceleration section 30, thereby further improving the mixing uniformity and mixing efficiency of the fluid in the acceleration section 30.

[0065] Please refer to Figure 3 , Figure 3 The structure of the flow channel 1 in the microfluidic chip is shown in the figure, wherein the flow channel 1 comprises a high-speed section 40.

[0066] In one embodiment, at least one set of two adjacent mixing sections 20 is provided with an acceleration section 30 and a high-speed section 40; the inlet of the high-speed section 40 is in communication with the outlet of the mixed flow section 23 of one mixing section 20, and the outlet of the high-speed section 40 is in communication with the mixed flow section 23 of another mixing section 20. That is, by avoiding the high-speed section 40 of the mixing section 20, part of the fluid can pass through the high-speed section 40 at high speed, thereby increasing the average flow rate of the fluid in the flow channel 1 and improving the production efficiency of nanoparticles; and the outlet of the high-speed section 40 is in communication with the mixed flow section 23 of the mixing section 20, so that the high-speed fluid flowing out of the high-speed section 40 can impact the fluid in the mixed flow section 23, thereby mixing the two parts of fluid and improving the mixing uniformity of the fluid.

[0067] In one embodiment, the high-speed section 40 is in a straight line shape, and the high-speed section 40 and the two mixing sections 20 connected therewith are vertically arranged.

[0068] At this time, the inlet and outlet of the acceleration section 30 and the high-speed section 40 are basically flush.

[0069] In one embodiment, the acceleration sections 30 are continuously arranged, and the high-speed sections 40 are arranged at intervals, that is, an acceleration section 30 is arranged between every two mixing sections 20, and only one of the two adjacent acceleration sections 30 in the plurality of acceleration sections 30 is correspondingly arranged with a high-speed section 40, so as to avoid that part of the fluid directly flows out through the plurality of high-speed sections 40 without passing through the mixing section.

[0070] In one embodiment, the acceleration sections 30 and the high-speed sections 40 are further arranged between the liquid inlet section 10 and the mixing section 20, the inlet of the acceleration section 30 arranged between the liquid inlet section 10 and the mixing section 20 is in communication with the outlet of the liquid inlet section 10, and the outlet is in communication with the inlet of the flow guiding section 21 of the mixing section 20; the inlet of the high-speed section 40 arranged between the liquid inlet section 10 and the mixing section 20 is in communication with the outlet of the liquid inlet section 10, and the outlet is in communication with the mixing section 23 of the mixing section 20, so as to realize the preliminary mixing of the two types of fluids entering from the liquid inlet section 10, and improve the subsequent mixing uniformity and mixing efficiency.

[0071] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A microfluidic chip, characterized by, The chip body is provided with a flow channel, which comprises a liquid inlet part and a plurality of mixing parts connected in sequence with the liquid inlet part; The liquid inlet part comprises two liquid inlet sections for two types of fluid respectively; The mixing part comprises a flow guiding section, a flow guiding section and a mixing section connected in sequence, the flow guiding section comprises a lower layer confluence area and an upper layer confluence area, the inlet of the flow guiding section is connected with the flow guiding section and is arranged opposite to the lower layer confluence area; the outlet of the flow guiding section is connected with the mixing section and is arranged opposite to the upper layer confluence area; The inlet of the flow guiding section is arranged opposite to the outlet, and the lower end of the outlet of the flow guiding section corresponds to the lower layer confluence area and the upper layer confluence area; The flow guiding section further comprises a flow guiding channel arranged between the lower layer confluence area and the upper layer confluence area, and the fluid passes through the flow guiding channel and enters the mixing section through the lower end of the outlet of the flow guiding section; The flow guiding section is arc-shaped and forms an outer channel and an inner channel, the inlet of the outer channel is arranged opposite to the lower layer confluence area, and the inlet of the inner channel is arranged opposite to the flow guiding channel.

2. The microfluidic chip of claim 1, wherein, The mixing section is arc-shaped and is arranged in central symmetry with the flow guiding section; the mixing section forms a vortex area corresponding to the outlet of the flow guiding channel, and the upper area of the vortex area is arranged opposite to the upper layer confluence area.

3. The microfluidic chip of claim 1, wherein, At least one group of adjacent two mixing parts in the plurality of mixing parts is provided with an acceleration part, the inner wall of the channel of the acceleration part is smoothly transitioned; the inlet of the acceleration part is connected with the outlet of the mixing section of one mixing part, and the outlet of the acceleration part is connected with the inlet of the flow guiding section of another mixing part.

4. The microfluidic chip of claim 3, wherein, The acceleration part is curved and has at least one inflection point; the acceleration part and the two mixing parts connected therewith are arranged vertically.

5. The microfluidic chip of claim 3, wherein, At least one group of adjacent two mixing parts in the plurality of mixing parts is provided with the acceleration part and a high-speed part at the same time; the inlet of the high-speed part is communicated with the outlet of the mixing section of one mixing part, and the outlet of the high-speed part is communicated with the mixing section of another mixing part.

6. The microfluidic chip of claim 5, wherein, The acceleration part and the high-speed part are also arranged between the liquid inlet part and the mixing part, the inlet of the acceleration part arranged between the liquid inlet part and the mixing part is communicated with the outlet of the liquid inlet part, and the outlet of the acceleration part is communicated with the inlet of the flow guiding section of the mixing part; the inlet of the high-speed part arranged between the liquid inlet part and the mixing part is communicated with the outlet of the liquid inlet part, and the outlet of the high-speed part is communicated with the mixing section of the mixing part.

7. The microfluidic chip of claim 1, wherein, The liquid inlet section is symmetrically provided with two buffer cavities near the end thereof.

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