Whitening and lightening skin compositions, creams and methods of making same

Abstract

The present application relates to the field of cosmetic technology, in particular to a whitening and brightening composition, a face cream and a preparation method thereof.The whitening and brightening composition comprises the following components in parts by weight: golden microalgae, yeast / rice fermentation product filtrate and N-acetylglucosamine; wherein the fermentation strain of the yeast / rice fermentation product filtrate is yeast.The whitening and brightening composition has outstanding whitening and brightening effect.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetic technology, in particular to a whitening and brightening composition, a cream and a preparation method thereof. BACKGROUND

[0002] With the improvement of people's quality of life, more and more attention is paid to skin care and maintenance. Bright and white skin is a form of beauty, and the market is flooded with various whitening products.

[0003] Generally speaking, human skin color mainly depends on three factors: melanin, blood and carotene. Among them, melanin is contained in keratinocytes, which is a very small brown or black particle, and is also the cause of skin "darkening".

[0004] Many current products have single whitening effect, only targeting a certain link in the development process of melanin, and cannot block the generation of melanin from the root, such as the popular acid brushing and exfoliating whitening method, which only works on the stratum corneum, and the whitening effect cannot be sustained and is highly irritating. SUMMARY

[0005] Therefore, the present application provides a whitening and brightening composition, a cream and a preparation method thereof.

[0006] The first aspect of the present application provides a whitening and brightening composition, and the technical solution is as follows:

[0007] A whitening and brightening composition, comprising golden microalgae, yeast / rice fermentation product filtrate and N-acetylglucosamine.

[0008] Among them, the fermentation strain of the yeast / rice fermentation product filtrate is yeast.

[0009] In some embodiments, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetylglucosamine is (0.01-1.4):(0.03-4.2):(0.02-2.8).

[0010] In some embodiments, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetylglucosamine is (1-1.4):(3-4.2):(2-2.8).

[0011] In some embodiments, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetylglucosamine is 1:3:2.

[0012] In some embodiments, the preparation method of the yeast / rice fermentation product filtrate comprises the following steps:

[0013] Culturing yeast to obtain a yeast liquid;

[0014] Cooking the rice to obtain cooked rice grains;

[0015] Inoculating the cooked rice grains with the yeast solution, and performing fermentation culture to prepare the yeast / rice fermentation product filtrate.

[0016] In some embodiments, the preparation parameters of the yeast / rice fermentation product filtrate satisfy one or more of the following conditions:

[0017] (1) the yeast species is saccharomyces veronae;

[0018] (2) the mass of the yeast solution is 10wt%-20wt% of the cooked rice grains;

[0019] (3) the temperature of the fermentation culture is 35℃-40℃;

[0020] (4) the time of the fermentation culture is 24h-72h.

[0021] In some embodiments, it further comprises phytosterol, squalane, tocopheryl acetate, and behenyl alcohol.

[0022] In some embodiments, the mass ratio of the golden microalgae, yeast / rice fermentation product filtrate, N-acetylglucosamine, phytosterol, squalane, tocopheryl acetate, and behenyl alcohol is (0.01-1.4):(0.03-4.2):(0.02-2.8):(1-5):(0.5-4):(1-6):(1-5).

[0023] The second aspect of the present application provides a face cream, and the technical solution is as follows:

[0024] A face cream comprises the following components in the following weight percentages:

[0025] The whitening and skin-lightening composition is 0.05wt%-25wt%, the thickening agent is 10wt%-20wt%, the chelating agent is 0.01wt%-0.2wt%, the skin feel modifier is 0.1wt%-8wt%, the solubilizing agent is 0.5wt%-5wt%, and the solvent is 42wt%-78wt%.

[0026] The third aspect of the present application provides a face cream, and the technical solution is as follows:

[0027] A face cream comprises the following components in the following weight percentages:

[0028] The chlorella is 0.01wt%-5wt%, the yeast / rice fermentation product filtrate is 0.01wt%-50wt%, the N-acetylglucosamine is 0.01wt%-5wt%, the phytosterol is 1wt%-5wt%, the squalane is 0.5wt%-4wt%, the tocopheryl acetate is 1wt%-6wt%, the bebenyl alcohol is 1wt%-5wt%, the acrylic acid sodium / acryloyldimethyltaurate copolymer is 1wt%-5wt%, the xanthan gum is 3wt%-6wt%, the carboxymethyl cellulose is 3wt%-7wt%, the kaolin is 1wt%-4wt%, the titanium dioxide is 0.5wt%-3wt%, the ethylenediaminetetraacetic acid disodium is 0.01wt%-0.2wt%, the isononyl isononanoate is 0.1wt%-8wt%, the polyethylene glycol stearate is 0.5wt%-5wt%, and the solvent is 37wt%-78wt%.

[0029] In some embodiments, one or more of a preservative and a fragrance are also included.

[0030] The fourth aspect of the present application provides a preparation method of a face cream, and the technical scheme is as follows:

[0031] The preparation method of the face cream comprises the following steps:

[0032] Mixing a solvent, a part of thickening agent and a chelating agent to prepare a first mixed solution;

[0033] Mixing the first mixed solution, the remaining thickening agent, a whitening and skin lightening composition and a skin feel regulator to prepare a second mixed solution;

[0034] Mixing the second mixed solution and a solubilizing agent to emulsify.

[0035] Compared with the conventional scheme, the present application has the following beneficial effects:

[0036] In the present application, the golden microalgae, yeast / rice fermentation product filtrate and N-acetyl glucosamine are used synergistically to achieve a safe and lasting whitening effect from the root. Specifically, many whitening ingredients can directly act on cells, but when applied to skin care products, the transdermal property needs to be considered. Whether the effective ingredient can penetrate the stratum corneum and epidermis to reach a certain concentration in the deep layer of the skin to work is a big problem. In the present application, small molecules or ingredients with excellent penetration are used to improve the transdermal property of the effective ingredient from the source. On this basis, the yeast / rice fermentation product filtrate as a good accelerator can promote the golden microalgae and N-acetyl glucosamine effective ingredients to reach the deep layer of the skin. In the deep layer of the skin and cells, the three substances act together or in pairs to interfere with almost the whole process of melanin production. On the one hand, it reduces the production of free radicals and reduces the amount of melanin. On the other hand, the golden microalgae and N-acetyl glucosamine can affect the enzyme activity of the melanin metabolic pathway to accelerate the metabolism of melanin, and can also accelerate the separation of melanin deposited on the surface of the skin. By interfering with almost the whole process of melanin production, the amount of melanin is reduced from the root, and the whitening effect can be maintained more persistently.

[0037] At the same time, many whitening products currently use ingredients with weak stability, which are easy to decompose or react, have strong irritation and even toxicity, and are easy to cause skin adverse reactions. For example, arbutin can quickly whiten but is unstable and easy to decompose, greatly reducing the whitening effect. Vitamin C, retinol and the like are also prone to oxidation, instability and even cytotoxicity, and can metabolize toxic ingredients in the skin. In the present application, the golden microalgae, yeast / rice fermentation product filtrate and N-acetyl glucosamine are all derived from natural organisms, and have good biological activity and safety by using the characteristics of biological resistance, enrichment and transformation, and fermentation metabolism, and by enrichment, extraction and combination. DETAILED DESCRIPTION

[0038] The present application is further described in conjunction with the specific embodiments. The present application can be realized in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided so that the disclosure of the present application can be more thoroughly and completely understood.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

[0040] Terminology

[0041] Unless otherwise indicated or unless the context clearly indicates otherwise, the terms or phrases used in this document have the following meanings:

[0042] In the present application, the selection range involving "and / or", "or / and", "and / or" includes any one of two or more related listed items, and also includes any and all combinations of the related listed items, which includes any two related listed items, any more related listed items, or all related listed items. It should be noted that when at least three items are connected by at least two conjunctions selected from "and / or", "or / and", "and / or", it should be understood that the technical solution undoubtedly includes the technical solution connected by "logical and", and also undoubtedly includes the technical solution connected by "logical or". For example, "A and / or B" includes three parallel schemes of A, B and A+B. For another example, the technical solution of "A, and / or, B, and / or, C, and / or, D" includes any one of A, B, C and D (i.e. the technical solution connected by "logical or"), and also includes any and all combinations of A, B, C and D, i.e. includes the combination of any two or any three of A, B, C and D, and also includes the four-item combination of A, B, C and D (i.e. the technical solution connected by "logical and").

[0043] In the present application, "multiple", "multiple", "multiple", "multiple" and the like are used without special limitation, which means greater than or equal to 2 in quantity. For example, "one or more" means one or more than or equal to two.

[0044] In the present application, "optionally", "optional" and "optional" mean optional, i.e. selected from two parallel schemes of "have" or "have". If there are multiple "optional" in a technical solution, and there is no special description, contradiction or mutual restriction, each "optional" is independent.

[0045] In the present application, in the "first aspect", "second aspect", "third aspect", "fourth aspect" and the like, the terms "first", "second", "third", "fourth" and the like are only used for description purposes, and cannot be understood as indicating or implying relative importance or quantity, nor can it be understood as implicitly indicating the importance or quantity of the indicated technical features. Moreover, "first", "second", "third", "fourth" and the like only serve the purpose of non-exhaustive enumeration and description, and should be understood as not constituting a closed limitation on the quantity.

[0046] In the present application, when a numerical interval (i.e. a numerical range) is involved, unless otherwise specified, the optional numerical distribution within the numerical interval is considered to be continuous, and includes both numerical endpoints (i.e. the minimum and maximum values) of the numerical range, and every number between the two numerical endpoints. When a numerical interval refers to only integers within the numerical interval, unless otherwise specified, the two endpoints and every integer between the two endpoints are included in the numerical range, and in this context, it is equivalent to directly listing every integer, for example, t is an integer selected from 1 to 10, which means t is any one integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10. In addition, when multiple ranges are provided to describe a feature or characteristic, these ranges can be combined. In other words, unless otherwise specified, the ranges disclosed herein should be understood to include any and all sub-ranges encompassed therein.

[0047] In the present application, the temperature parameter, unless otherwise specified, allows both constant temperature treatment and variation within a certain temperature interval. It should be understood that the constant temperature treatment allows the temperature to fluctuate within the accuracy range controlled by the instrument. It is allowed to fluctuate within the range of, for example, ±5°C, ±4°C, ±3°C, ±2°C, ±1°C.

[0048] In the present application, % (w / w) and wt% both represent weight percentage, % (v / v) refers to volume percentage, and % (w / v) refers to mass volume percentage.

[0049] The first aspect of the present application provides a whitening and brightening composition, in one embodiment, the whitening and brightening composition comprises golden microalgae, yeast / rice fermentation product filtrate and N-acetyl glucosamine.

[0050] In the present application, the fermentation strain of the yeast / rice fermentation product filtrate is yeast.

[0051] Optionally, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetyl glucosamine is (0.01-1.4):(0.03-4.2):(0.02-2.8).

[0052] Optionally, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetyl glucosamine is (1-1.4):(3-4.2):(2-2.8).

[0053] Further optionally, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate and the N-acetyl glucosamine is 1:3:2.

[0054] The microalgae is an ancient organism that can adapt to various extreme environments and has diversified potential chemical components and metabolic physiological characteristics. In the production mode of the golden microalgae adopted in the application, the microalgae extract and gold are cultured together in a specific closed bioreactor under specific culture conditions such as light and pH, so that the "mineral gold" is converted into biological gold with low stimulation, high nutrition and high activity. The microalgae in the microalgae extract is preferably the following organism: selected door: Chlorophyta, family: Chlorodendraceae, genus: Tetraselmis, species: Tetraselmis suecica. The guaranteed content of gold in the golden microalgae is 2-10 mg / L. -1 Meanwhile, the golden microalgae contains various polysaccharides, oligosaccharides and other sugars, chlorophyll, amino acids, proteins, minerals, vitamins and other active ingredients.

[0055] Generally, the melanin that makes the skin black includes the following processes: the epidermal cells are stimulated by ultraviolet rays, pollution and the like to produce free radicals, the free radicals stimulate the activation of the pigment cells to produce melanin, the melanin is transferred to the epidermal cells, is accumulated in the epidermal horny layer to make the skin black. The golden microalgae can participate in the regulation of the gene expression of the skin pigment deposition related metabolic pathways, so as to regulate the enzyme activity and the formation of the pigment precursor, and finally reduce the production and accumulation of melanin. Meanwhile, it has strong antioxidant effect, can reduce the production of free radicals, prevent the activation of the melanin precursor cells and thus reduce the production of melanin. In addition, the biological gold therein has the effect of helping the absorption of the effective components in the skin care products based on the action of the micro electric field, and itself has the effects of anti-inflammatory and sterilization, anti-aging and antioxidant, improving the skin metabolic capacity and enhancing the cell vitality, can promote the proliferation of the epidermal cells, accelerate the skin blood microcirculation, neutralize the free radicals in the body and endogenously brighten the skin. Moreover, it has high efficient reactivating activity, can accelerate the repair and regeneration of the cells, realize the regeneration and reconstruction of the skin structure, reduce the skin aging phenomenon, make the skin bright and lively, and thus plays the whitening and lightening effect.

[0056] In the embodiment, the golden microalgae is purchased from Weidan Biotechnology Co., Ltd.

[0057] The yeast / rice fermentation product filtrate refers to the fermentation liquid obtained by inoculating the fermentation strain and culturing the fermentation with rice as the fermentation substrate.

[0058] In the embodiment, the fermentation strain of the yeast / rice fermentation product filtrate is yeast. After inoculating the yeast and culturing the fermentation, the obtained yeast / rice fermentation product filtrate contains more than 90 kinds of nutritional components, including amino acids, adenosine, polysaccharides, minerals and the like.

[0059] Preferably, the present embodiment selects a high-efficiency and suitable yeast named saccharomyces veronae.

[0060] Optionally, the method for preparing the yeast / rice fermentation product filtrate comprises the following steps:

[0061] culturing the yeast to obtain a yeast liquid;

[0062] cooking the rice to obtain cooked rice grains;

[0063] inoculating the cooked rice grains with the yeast liquid and performing fermentation culture to prepare the yeast / rice fermentation product filtrate.

[0064] Further optionally, the mass of the yeast liquid is 10wt% to 20wt% of the mass of the cooked rice grains.

[0065] Further optionally, the fermentation culture is performed at a temperature of 35°C to 40°C. For example, the fermentation culture is performed at a temperature of 37°C.

[0066] Further optionally, the fermentation culture is performed for a time period of 24h to 72h. For example, the fermentation culture is performed for a time period of 48h.

[0067] It can be understood that the fermentation culture is performed in a clean and stable environment. After the fermentation culture, the filtrate can be collected by filtration treatment as the yeast / rice fermentation product filtrate.

[0068] It is proved by the contact angle comparison experiment and the moisturizing power experiment that the yeast / rice fermentation product filtrate prepared by the above method has better skin-friendliness and higher moisturizing power than water. In particular, it is found by the contact angle comparison experiment that the contact angle of the yeast / rice fermentation product filtrate is 82°, while the contact angle of refined water is 102°, which shows that the yeast / rice fermentation product filtrate has better skin-friendliness. It is found by the permeability experiment that the yeast / rice fermentation product filtrate prepared by the above method can increase the permeability of active ingredients by 26% compared with refined water, i.e., it can more effectively help other effective ingredients to penetrate into the skin without cell damage. In the present embodiment, the yeast / rice fermentation product filtrate is a safe and efficient ingredient with the effects of water replenishing and moisturizing and can be synergistically enhanced.

[0069] In particular, the inventors detected the presence of an effective concentration of adenosine in the filtrate of the yeast / rice fermentation product in the present embodiment. Adenosine is a nucleoside that can deliver energy in the form of ATP, ADP to provide cell vitality and inhibit the generation of oxygen free radicals in organisms. It was also found that substances containing adenosine can regulate MMP-1 to inhibit its synthesis. MMP-1 is an important skin aging-related protease, and an increase in its content will accelerate the decomposition of skin collagen, causing skin relaxation and wrinkles. Therefore, adenosine plays an important role in cell activation, anti-aging and anti-wrinkles. That is, the yeast / rice fermentation product filtrate of the present embodiment is expected to have a positive effect on cell activation, anti-aging and anti-wrinkles.

[0070] N-acetylglucosamine (NAG) is a monosaccharide with a structure similar to glucose, often extracted from marine shells, known as marine glucose, containing a nitrogen atom, with high thermal stability and pH robustness. It is widely present in the human body and is an important precursor for the synthesis of hyaluronic acid in organisms, which is very important for the fullness of the skin and cells. In particular, as a small molecule substance with a molecular weight of only 200 or more, NAG is easily absorbed and has better penetration than direct supplementation of hyaluronic acid. After entering the cell, it can supplement endogenous hyaluronic acid to make the skin moist and lustrous. For example, as the NAG concentration increases from 1 to 10 mM, the amount of hyaluronic acid produced in living organisms increases from 0.5 to 1.2 μg / well, and this effect can be achieved by enhancing the activity of hyaluronic acid synthase (HAS). At the same time, NAG is also a highly effective whitening ingredient that can remove melanin and keratin deposition pigments from multiple directions to achieve the effect of whitening. NAG can inhibit the glycosylation reaction of tyrosinase, making it unable to mature and thus unable to catalyze the synthesis of melanin. If melanin metabolism is not timely, melanin will deposit on the epidermis, causing the skin to appear dark and dull. NAG can competitively bind to CD44 glycoprotein in the intercellular matrix that mediates cell migration, locking, and other interactions, so that CD44 cannot establish a connection between cells to promote the natural separation and shedding of aging keratin. In particular, this is a mild and non-irritating way to exfoliate keratin, unlike brushing acid, which can damage the skin barrier. The use of NAG can better achieve the effect of whitening.

[0071] The golden microalgae, the yeast / rice fermentation product filtrate, and the N-acetyl glucosamine each has excellent effects in water replenishment, moisturizing, anti-aging, and whitening. In the present embodiment, the golden microalgae, the yeast / rice fermentation product filtrate, and the N-acetyl glucosamine are used in cooperation to exert force from each aspect and achieve a safe and persistent whitening effect from the root. Specifically, many whitening ingredients can directly act on cells, but when applied to skin care products, the transdermal property needs to be considered. Whether the effective ingredients can pass through the stratum corneum and epidermis to reach a certain concentration in the deep skin to function is a big problem. In the present embodiment, small molecules or ingredients with excellent proven penetration are used to improve the transdermal property of the effective ingredients from the source. On this basis, the yeast / rice fermentation product filtrate as a good accelerator can promote the golden microalgae and N-acetyl glucosamine effective ingredients to reach the deep skin. In the deep skin and cells, the three substances act simultaneously or in combination to interfere with almost the whole process of melanin production. On the one hand, the production of free radicals is reduced, and the amount of melanin is reduced. On the other hand, the golden microalgae and N-acetyl glucosamine can affect the enzyme activity of the melanin metabolic pathway to accelerate the metabolism of melanin, and can also accelerate the detachment of melanin deposited on the skin surface. Through almost the whole process of melanin production, the amount of melanin is reduced from the root, and the whitening effect can be maintained more persistently. At the same time, many ingredients used in current whitening products have weak stability, are easy to decompose or react, have strong irritation or even toxicity, and are easy to cause skin adverse reactions. For example, arbutin can quickly whiten but is unstable and easy to decompose, and the whitening effect is greatly reduced. Vitamin C, retinol, and the like are also easy to oxidize, unstable, and even may produce cytotoxicity, and are metabolized to generate toxic ingredients in the skin. In the present embodiment, the golden microalgae, the yeast / rice fermentation product filtrate, and the N-acetyl glucosamine are all derived from natural organisms, and are formed by enrichment, extraction, and combination by using the characteristics of biological resistance, enrichment and transformation, and fermentation metabolism. The substances have good biological activity and safety, and can achieve safety and effectiveness in whitening.

[0072] Optionally, the whitening and lightening composition further comprises phytosterol, squalane, tocopheryl acetate, and behenyl alcohol.

[0073] Optionally, the mass ratio of the golden microalgae, the yeast / rice fermentation product filtrate, N-acetyl glucosamine, phytosterol, squalane, tocopheryl acetate, and behenyl alcohol is (0.01-1.4):(0.03-4.2):(0.02-2.8):(1-5):(0.5-4):(1-6):(1-5).

[0074] The above whitening and lightening composition has good transdermal property, can penetrate into the deep skin and cells, remove free radicals, reduce melanin, and achieve the effect of persistent whitening, lightening, and gloss.

[0075] The second aspect of the present invention provides a face cream, in one embodiment, the face cream comprises the following components in the following weight percentages:

[0076] The whitening skin lightening composition comprises 0.05wt% to 25wt%, thickening agent 10wt% to 20wt%, chelating agent 0.01wt% to 0.2wt%, skin feel modifier 0.1wt% to 8wt%, solubilizer 0.5wt% to 5wt% and solvent 42wt% to 78wt%.

[0077] The weight percentage of the whitening skin lightening composition includes but is not limited to 0.05wt%, 1wt%, 5wt%, 10wt%, 12wt%, 15wt%, 20wt%, 25wt%.

[0078] The weight percentage of the thickening agent includes but is not limited to 10wt%, 12wt%, 15wt%, 20wt%.

[0079] The weight percentage of the chelating agent includes but is not limited to 0.01wt%, 0.1wt%, 0.2wt%.

[0080] The weight percentage of the skin feel modifier includes but is not limited to 0.1wt%, 1wt%, 5wt%, 8wt%.

[0081] The weight percentage of the solubilizer includes but is not limited to 0.5wt%, 0.1wt%, 1wt%, 5wt%.

[0082] The weight percentage of the solvent includes but is not limited to 42wt%, 50wt%, 64wt%, 78wt%.

[0083] Optionally, the thickening agent is selected from one or more of sodium acrylates / acryloyldimethyltaurate copolymer, xanthan gum, carboxymethylcellulose, kaolin and titanium dioxide.

[0084] Optionally, the chelating agent is selected from disodium ethylenediaminetetraacetate (EDTA-2Na), metal ion complex of EDTA, calcium acetate, calcium chloride, citric acid, calcium citrate salt, potassium citrate salt, sodium citrate salt, disodium salt of tri-ethylamine tetra-acetic acid, calcium disodium salt of tri-ethylamine tetra-acetic acid, calcium sodium sulfate, gluconic acid-delta-lactone, oxidized stearyl esters, monosodium diacetate, tartaric acid, sodium thioacetate or sorbitol.

[0085] Optionally, the skin feel modifier is selected from isononyl isononanoate, dimethicone, dimethiconol, PEG-11 methyl ether dimethicone, phytosteryl / octyldodecyl lauroyl glutamate, hydrogenated polyisobutene, rapeseed oil, polydecene, soybean oil or olive oil.

[0086] Optionally, the solubilizing agent is selected from the group consisting of polyethylene glycol stearate (PEG stearate), caprylic capric triglyceride, butylene glycol, hexylene glycol, pentylene glycol, PEG-40 hydrogenated castor oil, and the like.

[0087] Further optionally, the solubilizing agent is PEG-100 stearate.

[0088] Optionally, the solvent is water, further optionally, the solvent is deionized water.

[0089] Optionally, the cream further comprises one or more of a preservative and a fragrance.

[0090] Further optionally, the preservative is selected from the group consisting of one or more of phenoxyethanol and pentylene glycol.

[0091] A third aspect of the present application provides a cream, in one embodiment, the cream comprises the following components in the following weight percentages:

[0092] Chrysochromulina 0.01 wt% to 5 wt%, yeast / rice ferment filtrate 0.01 wt% to 50 wt%, N-acetyl glucosamine 0.01 wt% to 5 wt%, phytosteryl 1 wt% to 5 wt%, squalane 0.5 wt% to 4 wt%, tocopheryl acetate 1 wt% to 6 wt%, behenyl alcohol 1 wt% to 5 wt%, sodium acrylates / acryloyldimethyltaurate copolymer 1 wt% to 5 wt%, xanthan gum 3 wt% to 6 wt%, carboxymethyl cellulose 3 wt% to 7 wt%, kaolin 1 wt% to 4 wt%, titanium dioxide 0.5 wt% to 3 wt%, disodium EDTA 0.01 wt% to 0.2 wt%, isononyl isononanoate 0.1 wt% to 8 wt%, polyethylene glycol stearate 0.5 wt% to 5 wt%, solvent 37 wt% to 78 wt%.

[0093] In some examples, the cream comprises the following components in the following weight percentages:

[0094] Chrysochromulina 0.01 wt% to 1.4 wt%, yeast / rice ferment filtrate 0.03 wt% to 4.2 wt%, N-acetyl glucosamine 0.02 wt% to 2.8 wt%, phytosteryl 1 wt% to 5 wt%, squalane 0.5 wt% to 4 wt%, tocopheryl acetate 1 wt% to 6 wt%, behenyl alcohol 1 wt% to 5 wt%, sodium acrylates / acryloyldimethyltaurate copolymer 1 wt% to 5 wt%, xanthan gum 3 wt% to 6 wt%, carboxymethyl cellulose 3 wt% to 7 wt%, kaolin 1 wt% to 4 wt%, titanium dioxide 0.5 wt% to 3 wt%, disodium EDTA 0.01 wt% to 0.2 wt%, isononyl isononanoate 0.1 wt% to 8 wt%, polyethylene glycol stearate 0.5 wt% to 5 wt%, solvent 42 wt% to 78 wt%.

[0095] Optionally, the polyethylene glycol stearate is PEG-100 stearate.

[0096] Optionally, the solvent is water, further optionally, the solvent is deionized water.

[0097] Optionally, the cream further comprises one or more of a preservative and a fragrance.

[0098] Further optionally, the preservative is selected from one or more of phenoxyethanol and pentylene glycol.

[0099] The cream of the present embodiment has good transdermal property, and can penetrate into the skin and cells, remove free radicals, reduce melanin, and achieve the effects of persistent whitening, brightening and gloss.

[0100] The fourth aspect of the present application provides a preparation method of the above cream, in one embodiment, the preparation method of the cream comprises the following steps:

[0101] Mixing the solvent, part of the thickening agent and the chelating agent to prepare a first mixed solution;

[0102] Mixing the first mixed solution, the remaining part of the thickening agent, the whitening and brightening composition and the skin feel regulator to prepare a second mixed solution;

[0103] Mixing the second mixed solution and the solubilizing agent, and emulsifying.

[0104] The following is further illustrated in combination with specific examples and comparative examples, the raw materials involved in the following specific examples and comparative examples, if no special instructions, can be sourced from the market, the use of instruments, if no special instructions, can be sourced from the market, the process involved, if no special instructions, are the routine selection of those skilled in the art.

[0105] Examples 1-3

[0106] Referring to the weight percentage shown in Table 1, examples 1-3 provide a whitening and brightening composition, a cream and a preparation method of the cream, the steps are as follows,

[0107] 1) Preparation of yeast / rice fermentation product filtrate

[0108] The yeast (saccharomyces veronae) is inoculated into the sterilized activated culture medium, cultured at 28℃ for 48 hours, and prepared for use; under sterile conditions, the activated strain is transferred to the sterilized expansion culture medium with an inoculation ring, and placed in a constant temperature shaker, cultured at 150r / min and 28℃ for 48 hours. The expanded strain is inoculated into the MRS culture medium, the inoculation amount is 3%, and the culture is continued at 28℃ for 48 hours to obtain the yeast liquid.

[0109] Wash 20 g of rice with water, soak for 24 hours, steam in a pot until cooked, then put into a bottle, add deionized water, stand and cool to room temperature, and make the rice loose; take 15% of the mass of the cooked rice of the yeast liquid and add to the cooked rice, incubate at 37°C for 2 days, then stand and filter to collect the clear liquid, to obtain the yeast / rice fermentation product filtrate.

[0110] 2) Preparation of the first mixture

[0111] Wet and disperse A phase completely in water to obtain the first mixture.

[0112] 3) Preparation of the second mixture

[0113] Add B phase, C phase and E phase to the first mixture in step 2), heat to 60°C, homogenize at 3000 r / min for 3-5 minutes to disperse completely, to obtain the second mixture.

[0114] 4) Preparation of the cream

[0115] Add D phase to the second mixture in step 3), homogenize at 3000 r / min for 3 minutes to emulsify completely, heat to 60°C, to obtain the cream.

[0116] Table 1

[0117]

[0118] Comparative Examples 1-6

[0119] According to the weight percentages shown in Table 2 and the methods of Examples 1-3, Comparative Examples 1-6 provide a whitening and lightening composition, a cream and a method for preparing the cream.

[0120] Table 2

[0121]

[0122]

[0123] Test I

[0124] Whitening and lightening efficacy test

[0125] Test method: Under normal circumstances, through adult subjects, twice a day, morning and evening use of samples, continuous use of test samples for 56 days. A total of 90 people (10 people per example / comparative example subjects) were tested, Chinese healthy sensitive skin women, aged 28 to 50, with an average age of 38.55 ± 6.44, meeting the subject's voluntary selection and exclusion criteria. Instrument detection was performed before product use (D0), 7 days after product use (D7), 28 days after product use (D28), and 56 days after product use (D56).

[0126] A skin color meter CHROMAMETER CR-400 was used to detect skin color. Among them, the L* value represents the brightness of the skin, the larger the value, the more the color is biased towards white; the larger the ITA° value, the brighter the skin, and vice versa, the skin is duller.

[0127] A skin gloss meter Glossymeter GL200 was used to detect skin gloss. The measurement results are shown in Table 5, which is the average value of the measurements of 10 subjects in each group. The larger the measurement value, the greater the increase in skin gloss.

[0128] Table 3

[0129] Sample Before use After 7 days use After 28 days use 7 day growth % 28 day growth % Example 1 59.86 60.85 61.13 1.65 2.12 Example 2 58.23 59.52 59.72 2.21 2.56 Example 3 58.84 59.54 59.61 1.19 1.31 Comparative Example 1 59.95 60.45 60.60 0.83 1.08 Comparative Example 2 60.05 60.54 60.70 0.82 1.08 Comparative Example 3 60.15 60.62 60.83 0.78 1.13 Comparative Example 4 59.76 60.21 60.33 0.75 0.95 Comparative Example 5 59.62 60.01 60.21 0.65 0.99 Comparative Example 6 59.45 59.82 60.06 0.62 1.03

[0130] Table 4

[0131]

[0132]

[0133] Table 5

[0134] Sample Before use After 7 days use After 28 days use 7 day growth % 28 day growth % Example 1 7.87 8.5 8.91 8.01 13.21 Example 2 7.62 8.82 9.05 15.75 18.77 Example 3 7.93 8.45 8.72 6.56 9.96 Comparative Example 1 7.83 8.42 8.54 7.54 9.07 Comparative Example 2 7.72 8.31 8.42 7.64 9.07 Comparative Example 3 7.33 7.88 8.01 7.50 9.28 Comparative Example 4 7.68 8.02 8.22 4.43 7.03 Comparative Example 5 7.95 8.3 8.52 4.40 7.17 Comparative Example 6 8.25 8.6 8.8 4.24 6.67

[0135] As can be seen from Tables 3-5, after using the creams of Examples 1-3 for 7 and 28 days, the skin color L* value, ITA° value and skin gloss were significantly and significantly increased compared to before use, indicating that the simultaneous use of yeast / rice ferment filtrate containing adenosine, golden microalgae and N-acetyl glucosamine had better whitening, lightening and gloss effects. The creams of Comparative Examples 1-6 only contain two or one of the three ingredients, and the increase in skin color and gloss of each group after application is not as good as that of the examples. Therefore, it is proved that the yeast / rice ferment filtrate containing adenosine, golden microalgae and N-acetyl glucosamine have a synergistic effect.

[0136] The technical features of the above-described examples can be combined in any way. In order to make the description concise, not all possible combinations of the technical features in the above-described examples are described, however, as long as the combinations of the technical features do not exist contradictory, they should be considered as the scope of the present disclosure.

[0137] The above embodiments only express several implementation manners of the present application, which are described in a more specific and detailed manner, but cannot be understood as a limitation on the patent scope of the present application. It should be noted that, for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the present application, which all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A skin lightening and brightening composition, characterized by comprising: The chlorella aureus, the yeast / rice fermentation product filtrate and N-acetyl glucosamine; The fermentation strain of the yeast / rice fermentation product filtrate is yeast, and the yeast strain is saccharomyces veronae. The preparation method of the yeast / rice fermentation product filtrate comprises the following steps: Culturing the yeast to obtain a yeast liquid; Cooking rice to obtain cooked rice grains; The cooked rice grains are inoculated with the yeast liquid, and fermented and cultured for 24-72 hours to prepare the yeast / rice fermentation product filtrate. The mass ratio of the chlorella aureus, the yeast / rice fermentation product filtrate and N-acetyl glucosamine is (1-1.4):(3-4.2):(2-2.8).

2. The skin lightening and brightening composition according to claim 1, wherein The mass of the yeast liquid accounts for 10-20 wt% of the cooked rice grains.

3. The skin lightening and brightening composition according to claim 1, wherein The fermentation and culture temperature is 35-40°C.

4. The skin lightening and brightening composition according to claim 1, wherein The composition further comprises phytosterol, squalane, tocopherol acetate and behenyl alcohol.

5. A face cream characterized in that, The composition comprises the following components in the following weight percentages: The whitening and skin-lightening composition of any one of claims 1-4, 0.05-25 wt%, a thickening agent, 10-20 wt%, a chelating agent, 0.01-0.2 wt%, a skin feel modifier, 0.1-8 wt%, a solubilizing agent, 0.5-5 wt%, and a solvent, 42-78 wt%.

6. The face cream according to claim 5, characterized in that, The composition further comprises one or more of a preservative and a fragrance.

7. A process for the preparation of a cream as claimed in claim 5 or 6, characterized in that, The composition comprises the following steps: Mixing a solvent, a part of a thickening agent and a chelating agent to prepare a first mixed solution; Mixing the first mixed solution, the remaining part of the thickening agent, the whitening and skin-lightening composition and the skin feel modifier to prepare a second mixed solution; Mixing the second mixed solution and a solubilizing agent to emulsify.

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