A nutritional composition, nutritional powder, functional food and uses

Abstract

The present application provides a kind of nutritional composition, nutritional powder, functional food and application, belong to functional food technical field;The nutritional composition includes the following weight parts of component: collagen tripeptide 5~10 parts and low methoxyl pectin 3~5 parts, wherein, collagen tripeptide has the effect of promoting wound healing and improving skin health, low methoxyl pectin has significant effect in antioxidant, anti-inflammatory and enhancing immunity, helps to improve the efficiency and quality of wound repair process.The present application can realize the effect of synergistic complementation by compounding collagen tripeptide and low methoxyl pectin according to specific proportion, and the effect of overall improvement of wound repair and immunity improvement.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional foods, and in particular relates to a nutritional composition, nutritional powder, functional food and applications. Background Art

[0002] Trauma refers to tissue damage caused directly or indirectly by external forces. Wound repair refers to the process by which human tissue repairs and regenerates itself after trauma. Wound repair is a complex biological process involving multiple cell types, molecular signals, and physiological processes. An effective wound repair process is crucial for preserving tissue structural integrity, preventing infection, and restoring function.

[0003] Nutritional repair promotes the wound repair process by providing appropriate nutrients. Nutrients are crucial for processes such as cell proliferation, differentiation, protein synthesis, and anti-inflammatory responses. During the wound repair process, the supply of nutrients can accelerate wound healing, promote tissue regeneration, and reduce the risk of infection, thereby improving the efficiency and quality of wound repair.

[0004] Existing patents primarily address wound repair by correcting the patient's negative nitrogen balance and improving symptoms such as malnutrition. For example, patent CN109247585A discloses a formula food specifically formulated for trauma, infection, surgery, and other stressful conditions, using marine fish collagen peptides and cod protein oligopeptides as a matrix and creatively utilizing them as a nitrogen source. The formula fundamentally corrects the patient's negative nitrogen balance and improves symptoms such as malnutrition. Other patents address nutritional supplementation and treatment for trauma patients by incorporating traditional Chinese medicine ingredients and a variety of nutrients. For example, patent CN103431277B discloses a whole-grain nutritional formula food for trauma and surgical patients. The food is made from a mixture of millet, black rice, coix seed, glutamine, whey protein, arginine, traditional Chinese medicine powder, glutamic acid, steviol glycosides, and edible flavorings. The food offers nutritional health benefits and auxiliary therapeutic benefits for patients with open wounds, wound infections, burns, surgery, abscesses, and other body trauma.

[0005] Currently, there is no report in the prior art on the synergistic use of collagen tripeptide and low-methoxyl pectin to promote wound repair. Summary of the Invention

[0006] The object of the present invention is to provide a nutritional composition, nutritional powder, functional food and application. The nutritional composition of the present invention includes collagen tripeptide and low-methoxy pectin. Collagen tripeptide and low-methoxy pectin can be used synergistically to promote wound repair and improve repair efficiency.

[0007] The invention provides a nutritional composition comprising the following components in parts by weight: 5 to 10 parts of collagen tripeptide and 3 to 5 parts of low-methoxyl pectin.

[0008] Preferably, the weight average molecular weight of the collagen tripeptide is 50 to 1000 Da.

[0009] Preferably, the esterification degree of the low methoxyl pectin is 10% to 50%.

[0010] The present invention also provides a nutritional powder comprising the following raw materials: the nutritional composition described in the above scheme and an embedding auxiliary material; the embedding auxiliary material comprises one or more of β-cyclodextrin, resistant dextrin and maltodextrin.

[0011] The present invention also provides a method for preparing the nutritional powder described in the above scheme, comprising the following steps:

[0012] The nutritional composition is dissolved and mixed with the embedding auxiliary material, and then embedded, homogenized and dried in sequence to obtain nutritional powder.

[0013] The present invention also provides a functional food for trauma patients, comprising the nutritional composition or the nutritional powder described in the above scheme or the nutritional powder prepared by the preparation method, and also comprising food raw materials.

[0014] Preferably, the food raw material comprises the following components in parts by weight: 300-650 parts of carbohydrates, 80-200 parts of protein, 30-100 parts of fat, 0.1-2 parts of vitamins and 5-80 parts of minerals.

[0015] Preferably, the vitamins include the following components in parts by weight: 0.01-0.1 parts of vitamin A acetate, 0.02-0.08 parts of cholecalciferol, 0.03-0.15 parts of dl-α-tocopheryl acetate, 0.004-0.016 parts of phytonadione, 0.008-0.015 parts of thiamine nicotinate, 0.008-0.015 parts of riboflavin, 0.008-0.015 parts of pyridoxine hydrochloride, 0.001-0.006 parts of cyanocobalamin, 0.05-0.2 parts of L-ascorbic acid, 0.001-0.006 parts of folic acid and 0.005-0.04 parts of niacin.

[0016] Preferably, the mineral comprises calcium hydrogen phosphate.

[0017] The present invention also provides the use of the nutritional composition described in the above scheme or the nutritional powder or the nutritional powder prepared by the preparation method in preparing functional foods, special medical foods or medicines for consumption by trauma patients and / or for improving immunity.

[0018] The present invention provides a nutritional composition comprising the following components by weight: 5-10 parts of collagen tripeptide and 3-5 parts of low-methoxyl pectin. The collagen tripeptide plays an important role in promoting wound healing and improving skin health, and the low-methoxyl pectin has significant effects in anti-oxidation, anti-inflammatory and immune enhancement, which helps to improve the efficiency and quality of the wound repair process. The present invention combines the collagen tripeptide and low-methoxyl pectin, and the biological activities of the two can enhance each other. At the same time, the collagen tripeptide and low-methoxyl pectin can bind to cell surface receptors and trigger intracellular signal transduction pathways. After the two are combined, they can enhance the cell response to growth factors and immunomodulatory factors by enhancing the interaction of signal transduction, thereby accelerating wound repair. In addition, the low-methoxyl pectin has good drug carrier properties, can stabilize the collagen tripeptide, and release it in the target tissue. This synergistic effect can improve the stability and bioavailability of the collagen tripeptide, thereby exerting a longer-lasting and stronger effect in the wound repair and immune enhancement process. The present invention can achieve synergistic and complementary effects by compounding collagen tripeptide and low-methoxyl pectin in a specific ratio, thereby comprehensively improving the effects of wound repair and immune enhancement. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 is the serum hydroxyproline level of each study group after 14 days;

[0021] Figure 2 Comparison of wound area reduction in each study group after 14 days;

[0022] Figure 3 The comparison of wound area reduction rate in each research group after 14 days. DETAILED DESCRIPTION

[0023] The invention provides a nutritional composition comprising the following components in parts by weight: 5 to 10 parts of collagen tripeptide and 3 to 5 parts of low-methoxyl pectin.

[0024] In the present invention, the nutritional composition is preferably composed of the following components in parts by weight.

[0025] In the present invention, the nutritional composition includes 5 to 10 parts of collagen tripeptide, more preferably 7 to 9 parts, in parts by weight; the collagen tripeptide is a tripeptide with a basic amino acid at least at one end; the collagen tripeptide preferably includes one or more of Gly-X-Arg, Gly-X-His and Gly-X-Lys, wherein X is an amino acid; the weight-average molecular weight of the collagen tripeptide is preferably 50 to 1000 Da, more preferably 50 to 300 Da. In the present invention, the collagen tripeptide is preferably derived from deep-sea fish or freshwater fish skin, more preferably from tilapia. In the present invention, the collagen tripeptide can promote wound healing and skin regeneration. In the present invention, the collagen tripeptide was purchased from Wuhan Tiantianhao Biological Products Co., Ltd.

[0026] In the present invention, the nutritional composition comprises 3 to 5 parts by weight of low-methoxyl pectin, more preferably 3.5 to 4.5 parts, and most preferably 4 parts. Low-methoxyl pectin is a natural soluble polysaccharide. The degree of esterification of the low-methoxyl pectin is preferably 10% to 50%, more preferably 10% to 20%. In the present invention, low-methoxyl pectin has immunomodulatory functions and also has antioxidant and anti-inflammatory effects. In the present invention, the low-methoxyl pectin was purchased from Yantai DSM Andre Pectin Co., Ltd.

[0027] In the present invention, collagen tripeptide can promote wound healing and tissue regeneration, and low-methoxy pectin has antioxidant, anti-inflammatory and immunomodulatory functions. Collagen tripeptide and low-methoxy pectin have a synergistic effect in wound repair. The two interact with each other and complement each other, can enhance each other's biological activity, and further accelerate wound healing. The present invention compounds collagen tripeptide and low-methoxy pectin, which can significantly improve the effects of wound repair and immune enhancement. In addition, the present invention compounds collagen tripeptide and low-methoxy pectin and also shows excellent performance in improving skin health, antioxidant and anti-inflammatory.

[0028] The present invention also provides a nutritional powder comprising the following raw materials: the nutritional composition described in the above scheme and an embedding auxiliary material; the embedding auxiliary material comprises one or more of β-cyclodextrin, resistant dextrin and maltodextrin.

[0029] In the present invention, the mass ratio of the nutritional composition to the embedding excipient is preferably 1:1.

[0030] The present invention also provides a method for preparing the nutritional powder described in the above scheme, comprising the following steps:

[0031] The nutritional composition is dissolved and mixed with the embedding auxiliary material, and then embedded, homogenized and dried in sequence to obtain nutritional powder.

[0032] In the present invention, before dissolving the nutritional composition, the nutritional composition is preferably sieved to collect the undersize components; the aperture of the sieve is preferably 60 mesh.

[0033] In the present invention, the embedding time is preferably 1 to 3 hours, more preferably 2 hours; after the embedding, the present invention preferably further comprises hydration at 2 to 5°C overnight; the hydration temperature is preferably 3 to 5°C.

[0034] In the present invention, the homogenization is preferably high-pressure homogenization; the homogenization pressure is preferably 10 to 30 MPa, more preferably 10 to 18 MPa, and most preferably 15 MPa.

[0035] In the present invention, the drying is preferably spray drying; the inlet air temperature of the spray drying is preferably 135-165°C, more preferably 150-160°C; the outlet air temperature of the spray drying is preferably 130-145°C, more preferably 135-140°C; and the spray drying time is preferably a few seconds.

[0036] The present invention adopts beta-cyclodextrin to jointly embed the composition of collagen tripeptide and low-methoxy pectin, thereby optimizing the stability and palatability of the collagen tripeptide and low-methoxy pectin and increasing the bioavailability of the two.

[0037] The present invention also provides a functional food for trauma patients, comprising the nutritional composition or the nutritional powder described in the above scheme or the nutritional powder prepared by the preparation method, and also comprising food raw materials.

[0038] In the present invention, the food raw material preferably includes the following components in parts by weight: 300-650 parts of carbohydrates, 80-200 parts of protein, 30-100 parts of fat, 0.1-2 parts of vitamins and 5-80 parts of minerals.

[0039] In the present invention, the food raw material includes 300 to 650 parts by weight of carbohydrates, preferably 350 to 500 parts by weight; the carbohydrates preferably include maltodextrin; the DE value of the maltodextrin is preferably 18 to 20. Maltodextrin with this DE value has a slightly sweet taste, a certain hygroscopicity, an appropriate reducing sugar ratio, can undergo a browning reaction, has good solubility, and will not increase the viscosity when used in food.

[0040] In the present invention, the food raw material includes 80 to 200 parts of protein, preferably 80 to 90 parts, by weight; the protein preferably includes plant protein and animal protein; the plant protein preferably includes soy protein isolate; and the animal protein preferably includes whey protein isolate.

[0041] In the present invention, the food raw material includes 30 to 100 parts of fat, preferably 54 to 80 parts, by weight; the fat is preferably microcapsule powder of one or more of vegetable oil, saturated fatty acid and unsaturated fatty acid; the vegetable oil is preferably vegetable oil containing linoleic acid and α-linolenic acid, more preferably one or more of high oleic sunflower oil powder, soybean oil powder and linseed oil powder.

[0042] In the present invention, the functional ratio of carbohydrates, proteins and fats is preferably 58%:18%:24% or 60%:16%:24% or 55%:22%:23%.

[0043] In the present invention, the food raw material includes 0.1 to 2 parts of vitamins, more preferably 0.5 to 1 parts, by weight; the vitamins preferably include the following components by weight: 0.01 to 0.1 parts of vitamin A acetate, 0.02 to 0.08 parts of cholecalciferol, 0.03 to 0.15 parts of dl-α-tocopheryl acetate, 0.004 to 0.016 parts of phytonadione, 0.008 to 0.015 parts of thiamine nicotinate, 0.008 to 0.015 parts of riboflavin, 0.008 to 0.015 parts of pyridoxine hydrochloride, 0.001 to 0.015 parts of cyanocobalamin. 0.006 parts, L-ascorbic acid 0.05-0.2 parts, folic acid 0.001-0.006 parts and niacin 0.005-0.04 parts; more preferably, the vitamins preferably include the following components in parts by weight: 0.02 parts of vitamin A acetate, 0.02 parts of cholecalciferol, 0.03 parts of dl-α-tocopheryl acetate, 0.006 parts of phytonadione, 0.01 parts of thiamine nicotinate, 0.01 parts of riboflavin, 0.008 parts of pyridoxine hydrochloride, 0.003 parts of cyanocobalamin, 0.2 parts of L-ascorbic acid, 0.003 parts of folic acid and 0.01 parts of niacin.

[0044] In the present invention, the food raw material includes 5 to 80 parts of minerals, more preferably 10 to 50 parts, and most preferably 38 parts, by weight; the minerals preferably include calcium hydrogen phosphate, which is slightly soluble in water and does not significantly affect the properties of pectin in aqueous solution, so as to ensure that pectin can function in the body; more preferably, the minerals also include the following components by weight: 0.01 to 0.06 parts of D-pantothenate calcium, 0.003 to 0.018 parts of D-biotin, 2 to 40 parts of sodium chloride, 1 to 35 parts of magnesium oxide, 0.1 to 0.6 parts of ferric pyrophosphate, 0.1 to 0.8 parts of zinc oxide, 3-55 parts of potassium iodide, 0.0005-0.003 parts of sodium selenite, 0.012-0.05 parts of copper sulfate, 0.05-0.3 parts of manganese sulfate and 1-35 parts of citric acid; further preferably, the minerals include the following components in parts by weight: 0.02 parts of D-calcium pantothenate, 0.003 parts of D-biotin, 3.5-5 parts of calcium hydrogen phosphate, 16 parts of sodium chloride, 3.5 parts of magnesium oxide, 0.283 parts of ferric pyrophosphate, 0.28 parts of zinc oxide, 2.6 parts of potassium iodide, 0.012 parts of sodium selenite, 0.012 parts of copper sulfate, 0.09 parts of manganese sulfate and 2.1 parts of citric acid.

[0045] In the present invention, the raw material of the functional food is preferably the undersize component of a 60-mesh sieve.

[0046] In the present invention, the functional food is preferably prepared by the following method:

[0047] The raw materials of the functional food are mixed to obtain the functional food.

[0048] In the present invention, the mixing method is preferably to mix in a step-by-step equal amount increasing method.

[0049] After the mixing, the present invention preferably further comprises packaging the mixed materials to obtain a functional food product.

[0050] The present invention also provides the use of the nutritional composition described in the above scheme or the nutritional powder or the nutritional powder prepared by the preparation method in preparing functional foods, special medical foods or medicines for consumption by trauma patients and / or for improving immunity.

[0051] The nutritional composition, nutritional powder or functional food of the present invention can repair wounds and can be used for nutritional health care and auxiliary treatment of wound patients.

[0052] To further illustrate the present invention, a nutritional composition, nutritional powder, functional food and applications provided by the present invention are described in detail below with reference to the accompanying drawings and examples, but they should not be construed as limiting the scope of protection of the present invention.

[0053] Example 1

[0054] A composite functional food containing collagen tripeptide and low-methoxyl pectin, comprising the following components in parts by weight:

[0055] 300 parts of maltodextrin, 45 parts of isolated whey protein, 45 parts of isolated soy protein, 20 parts of high oleic sunflower oil powder, 15 parts of soybean oil powder, 19 parts of flaxseed oil powder, a collagen tripeptide and low methoxyl pectin combination (4 parts of low methoxyl pectin, 7 parts of collagen tripeptide powder), 0.5 parts of a vitamin combination, and 38 parts of a mineral combination. The semi-solidified nutrient has an energy supply ratio of 58%:18%:24% for maltodextrin, protein (isolated whey protein and isolated soy protein), and fat (high oleic sunflower oil powder, soybean oil powder, and flaxseed oil powder).

[0056] The vitamin composition consists of the following components by weight: 0.02 parts of vitamin A acetate, 0.02 parts of cholecalciferol, 0.03 parts of dl-α-tocopheryl acetate, 0.006 parts of phytonadione, 0.01 parts of thiamine nicotinate, 0.01 parts of riboflavin, 0.008 parts of pyridoxine hydrochloride, 0.003 parts of cyanocobalamin, 0.2 parts of L-ascorbic acid, 0.003 parts of folic acid and 0.01 parts of niacin.

[0057] The mineral composition consists of the following components by weight: 0.02 parts of D-calcium pantothenate, 0.003 parts of D-biotin, 5 parts of calcium hydrogen phosphate, 16 parts of sodium chloride, 3.5 parts of magnesium oxide, 0.283 parts of ferric pyrophosphate, 0.28 parts of zinc oxide, 2.6 parts of potassium iodide, 0.012 parts of sodium selenite, 0.012 parts of copper sulfate, 0.09 parts of manganese sulfate and 2.1 parts of sodium citrate.

[0058] The specific steps for preparing the composite functional food containing collagen tripeptide and low-methoxyl pectin are as follows:

[0059] Step 1, sieving: passing the enzymatically hydrolyzed collagen tripeptide, low methoxyl pectin, maltodextrin, whey protein isolate, soy protein isolate, high oleic sunflower oil powder, soybean oil powder, linseed oil powder, vitamin A acetate, cholecalciferol, dl-α-tocopheryl acetate, phytonadione, thiamine nicotinate, riboflavin, pyridoxine hydrochloride, cyanocobalamin, L-ascorbic acid, folic acid, niacin, D-calcium pantothenate, D-biotin, calcium hydrogen phosphate, sodium chloride, magnesium oxide, ferric pyrophosphate, zinc oxide, potassium iodide, sodium selenite, copper sulfate, manganese sulfate and sodium citrate through a 60-mesh sieve;

[0060] Step 2, embedding: Mix the composite powder of collagen tripeptide powder and low methoxyl pectin thoroughly and dissolve them, add an equal amount of β-cyclodextrin, mix thoroughly and embed for 2 hours, and hydrate at 3-5°C overnight;

[0061] Step 3: Spray drying: homogenize the embedded collagen tripeptide powder under a pressure of 15 MPa, and then spray dry it with an air inlet temperature of 150°C and an air outlet temperature of 140°C.

[0062] Step 4: Mixing raw materials and auxiliary materials: Mix the spray-dried collagen tripeptide powder with other raw materials in proportion and in equal and increasing amounts step by step. After fully mixing, package and you can get the finished product.

[0063] Example 2

[0064] A composite functional food containing collagen tripeptide and low-methoxyl pectin, comprising the following components in parts by weight:

[0065] 400 parts of maltodextrin, 40 parts of isolated whey protein, 40 parts of isolated soy protein, 20 parts of high-oleic sunflower oil powder, 15 parts of soybean oil powder, 19 parts of flaxseed oil powder, a collagen tripeptide and low-methoxyl pectin combination (3 parts of low-methoxyl pectin, 8 parts of collagen tripeptide powder), 0.5 parts of a vitamin combination, and 38 parts of a mineral combination. The semi-solidified nutritional supplement has an energy supply ratio of 60%:16%:24% for maltodextrin, protein (isolated whey protein and isolated soy protein), and fat (high-oleic sunflower oil powder, soybean oil powder, and flaxseed oil powder).

[0066] The vitamin composition consists of the following components by weight: 0.02 parts of vitamin A acetate, 0.02 parts of cholecalciferol, 0.03 parts of dl-α-tocopheryl acetate, 0.006 parts of phytonadione, 0.01 parts of thiamine nicotinate, 0.01 parts of riboflavin, 0.008 parts of pyridoxine hydrochloride, 0.003 parts of cyanocobalamin, 0.2 parts of L-ascorbic acid, 0.003 parts of folic acid and 0.01 parts of niacin.

[0067] The mineral composition consists of the following components by weight: 0.02 parts of D-calcium pantothenate, 0.003 parts of D-biotin, 3.5 parts of calcium hydrogen phosphate, 16 parts of sodium chloride, 3.5 parts of magnesium oxide, 0.283 parts of ferric pyrophosphate, 0.28 parts of zinc oxide, 2.6 parts of potassium iodide, 0.012 parts of sodium selenite, 0.012 parts of copper sulfate, 0.09 parts of manganese sulfate and 2.1 parts of sodium citrate.

[0068] The specific steps for preparing the composite functional food containing collagen tripeptide and low-methoxyl pectin are as follows:

[0069] Step 1, sieving: passing the enzymatically hydrolyzed collagen tripeptide, low methoxyl pectin, maltodextrin, whey protein isolate, soy protein isolate, high oleic sunflower oil powder, soybean oil powder, linseed oil powder, vitamin A acetate, cholecalciferol, dl-α-tocopheryl acetate, phytonadione, thiamine nicotinate, riboflavin, pyridoxine hydrochloride, cyanocobalamin, L-ascorbic acid, folic acid, niacin, D-calcium pantothenate, D-biotin, calcium hydrogen phosphate, sodium chloride, magnesium oxide, ferric pyrophosphate, zinc oxide, potassium iodide, sodium selenite, copper sulfate, manganese sulfate and sodium citrate through a 60-mesh sieve;

[0070] Step 2, embedding: Mix the composite powder of collagen tripeptide powder and low methoxy pectin thoroughly and dissolve them, add an equal amount of resistant dextrin, mix thoroughly and embed for 1.5 hours, and hydrate at 5°C overnight;

[0071] Step 3: Spray drying: homogenize the embedded collagen tripeptide powder under a pressure of 15 MPa, and then spray dry it with an air inlet temperature of 165°C and an air outlet temperature of 145°C.

[0072] Step 4: Mixing raw materials and auxiliary materials: Mix the spray-dried collagen tripeptide powder with other raw materials in proportion and in equal and increasing amounts step by step. After fully mixing, package and you can get the finished product.

[0073] The preparation method of the semi-solidified nutrient product in this embodiment is the same as that in Example 1, except that the embedding auxiliary material of the collagen tripeptide powder is resistant dextrin, and the embedding time and temperature are also adjusted accordingly.

[0074] Example 3

[0075] A composite functional food containing collagen tripeptide and low-methoxyl pectin, comprising the following components in parts by weight:

[0076] 350 parts of maltodextrin, 50 parts of isolated whey protein, 40 parts of isolated soy protein, 20 parts of high-oleic sunflower oil powder, 15 parts of soybean oil powder, 19 parts of flaxseed oil powder, a collagen tripeptide and low-methoxyl pectin combination (3.5 parts of low-methoxyl pectin, 7.5 parts of collagen tripeptide powder), 0.5 parts of a vitamin combination, and 38 parts of a mineral combination. The semi-solidified nutrient has an energy supply ratio of 55%:22%:23% for maltodextrin, protein (isolated whey protein and isolated soy protein), and fat (high-oleic sunflower oil powder, soybean oil powder, and flaxseed oil powder).

[0077] The vitamin composition consists of the following components by weight: 0.02 parts of vitamin A acetate, 0.02 parts of cholecalciferol, 0.03 parts of dl-α-tocopheryl acetate, 0.006 parts of phytonadione, 0.01 parts of thiamine nicotinate, 0.1 parts of riboflavin, 0.008 parts of pyridoxine hydrochloride, 0.003 parts of cyanocobalamin, 0.2 parts of L-ascorbic acid, 0.003 parts of folic acid and 0.01 parts of niacin.

[0078] The mineral composition consists of the following components by weight: 0.02 parts of D-calcium pantothenate, 0.003 parts of D-biotin, 3.5 parts of calcium hydrogen phosphate, 16 parts of sodium chloride, 3.5 parts of magnesium oxide, 0.283 parts of ferric pyrophosphate, 0.28 parts of zinc oxide, 2.6 parts of potassium iodide, 0.012 parts of sodium selenite, 0.012 parts of copper sulfate, 0.09 parts of manganese sulfate and 2.1 parts of sodium citrate.

[0079] The preparation method of the semi-solidified nutrient product in this embodiment is the same as that in Example 2.

[0080] Test example

[0081] Effect of enteral nutrition supplemented with collagen tripeptide and low-methoxyl pectin on wound recovery in trauma patients

[0082] 1. Research Objectives

[0083] To verify the effect of enteral nutrition supplemented with collagen tripeptide and low-methoxyl pectin composition (hereinafter referred to as composition) on wound recovery and nutritional improvement in surgical patients such as trauma

[0084] 2. Study Design

[0085] Type of study design: This study was a single-blind, randomized, controlled, prospective interventional study.

[0086] Sample size: 162 cases (36 cases in the pilot study and 126 cases in the formal study).

[0087] 3. Research Methods

[0088] A series of assessments were taken by a special evaluator on the patient. After the assessment, the patient met the inclusion criteria, agreed with the patient and signed the informed consent form. A total of 162 patients were recruited. After enrollment, all subjects were screened for nutritional risk by a special researcher and basic information, blood data, wound (wound) data, surgical category, current medical history and past medical history of all subjects were collected. All subjects were tested for serum hydroxyproline, serum albumin, prealbumin, liver and kidney function, serum inflammatory factors, body composition and the area of ​​wound (wound) at baseline. After 2 weeks, the experimental group received the intervention of the functional food added in Example 1, the control group 1 received the enteral nutrition preparation intervention containing collagen tripeptide, the control group 2 received the enteral nutrition preparation intervention containing low methoxy pectin, and the control group 3 (positive control group) received the conventional enteral nutrition preparation intervention. All were oral nutritional preparations, and the single dosage and frequency per unit weight of the intervention group and the control group remained consistent (dosage was calculated according to the brief nutritional assessment MNA scale). Participants were followed up on days 3, 6, 9, 12, and 14 after enrollment. Nutritional information, blood count, body composition, wound area, and efficacy data were collected. The wound area reduction rate, relative wound healing rate, wound healing efficacy, and serum hydroxyproline levels were analyzed between the control and intervention groups.

[0089] 4. Research Results

[0090] 4.1 Serum hydroxyproline level is a direct biochemical indicator of wound repair. After 14 days, the serum hydroxyproline level in the experimental group was significantly higher than that in the control group. Figure 1 .

[0091] 4.2 After 14 days, the wound area reduction rate in the experimental group was significantly higher than that in the control group. Figure 2 and Figure 3 .

[0092] 5. Conclusion

[0093] Enteral nutrition containing a combination of collagen tripeptide and low-methoxyl pectin has a better effect on wound recovery in surgical patients such as trauma than adding any single component, and is far superior to traditional enteral nutrition preparations without the above components.

[0094] Although the above embodiment provides a detailed description of the present invention, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the scope of protection of the present invention.

Claims

1. A functional food for trauma patients, characterized in that: Including nutritional powders and food ingredients; The nutritional powder is composed of the following raw materials: a nutritional composition and an embedding auxiliary material; the embedding auxiliary material is one or more of β-cyclodextrin, resistant dextrin and maltodextrin; The nutritional composition is composed of the following components in parts by weight: 5 to 10 parts of collagen tripeptide and 3 to 5 parts of low-methoxyl pectin; The food raw material is composed of the following components in parts by weight: 300-650 parts of carbohydrates, 80-200 parts of protein, 30-100 parts of fat, 0.1-2 parts of vitamins and 5-80 parts of minerals; The vitamins are composed of the following components in parts by weight: 0.01-0.1 parts of vitamin A acetate, 0.02-0.08 parts of cholecalciferol, 0.03-0.15 parts of dl-α-tocopheryl acetate, 0.004-0.016 parts of phytonadione, 0.008-0.015 parts of thiamine nicotinate, 0.008-0.015 parts of riboflavin, 0.008-0.015 parts of pyridoxine hydrochloride, 0.001-0.006 parts of cyanocobalamin, 0.05-0.2 parts of L-ascorbic acid, 0.001-0.006 parts of folic acid and 0.005-0.04 parts of niacin; The mineral is calcium hydrogen phosphate; The collagen tripeptide is one or more of Gly-X-Arg, Gly-X-His and Gly-X-Lys, wherein X is an amino acid.

2. The functional food according to claim 1, characterized in that The esterification degree of the low methoxyl pectin is 10% to 50%.

3. The functional food according to claim 1, characterized in that The preparation method of the nutritional powder comprises the following steps: dissolving the nutritional composition and mixing it with an embedding auxiliary material, and then embedding, homogenizing and drying in sequence to obtain the nutritional powder.

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