A nebulizer for administering a drug by nebulization and inhalation

Abstract

The present application relates to a kind of atomization and inhale type atomization administration device, including upper shell, lower shell, dosing control component, drug storage component, atomization component and power supply component, the drug storage component is set in upper shell, for providing drug liquid to atomization component;The atomization component is arranged between upper shell and lower shell, for atomizing the drug liquid provided by drug storage component;The dosing control component is used to control the work of atomization component;The power supply component is used to power dosing control component and atomization component;Atomization outlet is provided on the lower shell, for discharging the drug liquid after atomization, and the atomization administration device can store and atomize liquid drug preparation, and provide patient with real-time atomization inhalation, realize treatment or immunization effect etc..

Description

Technical Field

[0001] This invention relates to the field of medical devices, specifically to a nebulized drug delivery device that allows for both nebulization and inhalation, and more specifically to a nebulized drug delivery device for vaccine delivery that allows for both nebulization and inhalation. Background Technology

[0002] With increasingly severe air pollution and sudden changes in temperature during seasonal transitions, the number of patients with respiratory diseases has increased significantly.

[0003] One treatment for respiratory diseases is nebulized inhalation, which uses a nebulizer to disperse the medication into fine droplets, which are then inhaled through the patient's nose or mouth. The nebulized medication acts directly on the target organs, increasing the local drug concentration and achieving a therapeutic effect. Nebulized inhalation has shown very good therapeutic effects for bronchiolitis, asthmatic bronchitis, bronchial asthma, acute and chronic bronchitis, acute laryngitis, and acute pneumonia.

[0004] Nebulized inhaled vaccines are vaccines administered through nebulization. Nebulized inhalation immunization refers to the process where the vaccine is atomized into tiny particles using a nebulizer, which are then inhaled. These particles enter the respiratory tract and lungs, stimulating mucosal immunity. To prevent cross-infection during immunization, the inhalation device used by the recipient should be sterilized or discarded after each use. Given the necessity of large-scale vaccination, providing a nebulized drug delivery device that prevents cross-infection, reduces drug waste, and achieves high inhalation immunization efficiency is an urgent problem to be solved.

[0005] Existing nebulizers primarily employ an inhalation-only delivery method, requiring pre-administration guidance for subjects. Children, and even many adults, often experience significant difficulties in controlling the frequency of inhalation and breathing, greatly impacting drug aerosol absorption. This is detrimental to immunization or disease treatment. Furthermore, simultaneous nebulization and inhalation poses a risk of cross-infection. Additionally, the curvature of the connection between the nozzle and the nebulizer body directly or indirectly affects nebulization efficiency. During inhalation, the aerosol impacting the corner where the nozzle connects to the nebulizer housing can cause drug aerosol deposition at the corner, reducing the amount of inhalable drug. Therefore, this problem urgently requires research and solutions. Summary of the Invention

[0006] To overcome the shortcomings of existing technologies, this invention provides a nebulized drug delivery device that allows for simultaneous nebulization and inhalation. This device generates a drug mist, which is then inhaled by the subject to achieve therapeutic or immunization effects. This solves the problems of cross-infection, high cost, low efficiency, and drug waste associated with existing nebulization devices that involve simultaneous nebulization and inhalation.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A nebulizing inhalation device includes an upper housing, a lower housing, a drug storage component, a drug delivery control component, a nebulizing component, and a power supply component;

[0009] The drug storage component is disposed inside the upper housing and is used to supply liquid medicine to the atomizing component;

[0010] The atomizing component is disposed between the upper and lower housings and is used to atomize the liquid medicine provided by the drug storage component;

[0011] The drug delivery control component is used to control the operation of the nebulization component;

[0012] The power supply component is used to supply power to the drug delivery control component and the nebulization component;

[0013] The lower shell is provided with an atomizing outlet for discharging the atomized medicine.

[0014] Furthermore, the upper shell and the lower shell are integrally formed, or the upper shell and the lower shell are detachably connected, and even further, the upper shell and the lower shell are fastened together.

[0015] Furthermore, the drug storage assembly includes a liquid storage bottle, which is positioned above the atomizing assembly.

[0016] Furthermore, the drug storage assembly also includes a protective plug, which is used to seal the liquid storage bottle, for example, by magnetic attraction, fastening, or threaded rotation. Even further, the protective plug can be separated from the liquid storage bottle, or the protective plug can be connected to the liquid storage bottle via a connector to prevent loss of the protective plug.

[0017] Furthermore, the atomizing assembly includes a vibrating mesh nebulizer, which is disposed between the upper housing and the lower housing. Even further, the vibrating mesh nebulizer is disposed below the drug storage assembly.

[0018] Furthermore, the drug delivery control component includes an air inlet, an air switch for sensing airflow, and a control unit; the air inlet is located on the lower housing, and the air switch is located at the air inlet; the control unit receives signals from the air switch to control the operation of the atomizing component.

[0019] Furthermore, the air switch is connected to the control unit and the atomizing component via wires. Changes in air pressure activate the air switch, which senses airflow and converts the change into current, which is then sent to the control unit for amplification. The control unit outputs a signal to control the atomizing component.

[0020] Furthermore, the air inlet is located at the bottom of the lower housing.

[0021] Furthermore, the control unit is an MCU control unit, and even further, the control unit is disposed within the upper housing. Even further still, the control unit is disposed within the upper housing, to the side of the liquid storage assembly.

[0022] Furthermore, the drug delivery control component also includes a driving indicator light for the vibrating screen, used to indicate whether the driving vibrating screen is working. Even further, the driving indicator light is located on the MCU control unit.

[0023] Furthermore, the power supply component includes a power connector or power cord. The power supply component is electrically connected to the drug delivery control component and the nebulizer component, and is used to supply power to the drug delivery control component and the nebulizer component. More preferably, the power supply component also includes a switch and a power indicator light; the switch is used to control the operation of the power supply component, and the power indicator light is used to indicate whether the power supply component is operating.

[0024] Furthermore, a suction nozzle interface is provided on the side of the lower housing, with one side of the suction nozzle interface connected to the lower housing and the other side serving as an atomization outlet.

[0025] Furthermore, the atomizing inhalation device also includes an inhalation component. Even further, the inhalation component is a mouthpiece, and the mouthpiece is connected to a mouthpiece interface.

[0026] Furthermore, the suction nozzle and the suction nozzle interface can be integrally formed or detachably connected. Even further, the suction nozzle and the suction nozzle interface are slidably connected. Still further, the diameter of the suction nozzle interface is 10-30mm, for example, 10, 15, 20, 25, or 30mm.

[0027] Furthermore, the connection between the lower housing and the nozzle interface is a right angle or a rounded corner. Further, when the connection between the lower housing and the nozzle interface is a rounded corner, the chamfer radius R is 5-40 mm, preferably R = 10-30 mm, for example, 5, 10, 15, 20, 25, 30, 35, or 40 mm.

[0028] Furthermore, the vibrating screen atomizer is composed of a piezoelectric ceramic element and a vibrating screen sheet bonded together. The piezoelectric ceramic element can drive the vibration of the vibrating screen sheet, and the MCU control unit is electrically connected to the piezoelectric ceramic element.

[0029] Furthermore, the atomizing component also includes an upper sealing ring and a lower sealing ring, and the vibrating screen plate is fixed and sealed by the upper and lower sealing rings.

[0030] Furthermore, the drug delivery control component also includes an air inlet baffle and a baffle bracket, wherein the air inlet baffle and the baffle bracket are disposed at the air inlet, and the air inlet baffle is mounted on the baffle bracket. Preferably, the air inlet baffle is a one-way air inlet device.

[0031] Furthermore, the diameter of the lower housing is 10-40 mm, preferably 15-30 mm.

[0032] Furthermore, the vibrating screen plate is made of metal or a thin-film polymer material; preferably, the metal material is stainless steel or an alloy; more preferably, it is a palladium alloy; preferably, the thin-film polymer material is polypropylene (PP), polystyrene (PS), or polyimide (PI).

[0033] Furthermore, the power connection port is one of micro USB, USB Type-C, or Lightning interface.

[0034] The beneficial technical effects that this invention can achieve are as follows:

[0035] 1. The nebulizer of the present invention can be used to generate drug mist, which is then inhaled by the subject to achieve therapeutic or immune effects.

[0036] 2. The nebulizer of the present invention is an inhalation-driven nebulizer, which can significantly improve inhalation efficiency, thereby reducing the amount of medication that needs to be added to the nebulizer.

[0037] 3. When the chamfer radius at the connection between the lower housing and the nozzle interface in the nebulizer of the present invention is 5-40mm, preferably 10-30mm, the connection is more like a right angle, resulting in the highest amount of atomized medicine that can be inhaled, achieving a better atomization effect and ensuring complete absorption of the medicine. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the structure of an atomized and inhaled nebulized drug delivery device provided by the present invention;

[0039] Figure 2 for Figure 1 Enlarged diagram of A in the middle;

[0040] Figure 3 This is a schematic diagram of the exploded structure of an atomized and inhaled nebulized drug delivery device provided by the present invention.

[0041] Figure 4 A cross-sectional structural schematic diagram of a quantitative drug delivery control device for an instant atomization and inhalation nebulization drug delivery device provided by the present invention;

[0042] Figure 5A bar graph showing the relationship between different chamfer radii between the atomizer and the mouthpiece and the delivery rate (each group was tested 3 times, and the results of the first test, the second test, the third test, and the average of the three test results are shown from left to right in each group).

[0043] Figure 6 Bar graph showing the relationship between different chamfer radii between the atomizer and the mouthpiece and the total delivery volume (each group was tested 3 times, and the results of the first test, the second test, the third test, and the average of the three test results are shown from left to right).

[0044] Reference numerals: 1. Nozzle; 2. Lower housing; 3. Air inlet baffle; 4. Baffle bracket; 5. Air switch for sensing airflow; 6. Vibrating screen atomizer; 7. Upper sealing ring; 8. Lower sealing ring; 9. Upper housing; 10. Protective plug; 11. MCU control unit; 12. Power indicator light; 13. Working indicator light for driving the vibrating screen; 14. Switch; 15. Power cord; 16. Medicine storage bottle; 17. Nozzle interface; 18. Air inlet; 19. Power connection port. Detailed Implementation

[0045] Unless otherwise defined, all scientific and technical terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art.

[0046] All publications, patents, and published patent specifications cited in this article are incorporated herein in their entirety through citation.

[0047] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] Example 1

[0049] like Figure 1 As shown, a nebulizer that can atomize and inhale simultaneously includes an upper housing 9, a lower housing 2, a drug storage component, a drug delivery control component, a nebulization component, a power supply device, and an inhalation component.

[0050] The upper housing 9 and the lower housing 2 are fastened together.

[0051] The medication storage assembly includes a medication bottle 16 and a protective plug 10. The medication bottle 16 is located inside the upper housing 9 of the nebulizer. A removable protective plug 10 is installed on the top of the medication bottle 16 to facilitate the addition of liquid to the medication bottle 15.

[0052] The atomizing assembly includes a vibrating mesh atomizer 6, an upper sealing ring 7, and a lower sealing ring 8. The vibrating mesh atomizer 6 is installed between the upper housing 9 and the lower housing 2 of the atomizer, and is fixed and sealed by the upper sealing ring 7 and the lower sealing ring 8.

[0053] The drug delivery control assembly includes an air inlet 18, an air switch 5 that senses airflow, an MCU control unit 11, and an indicator light 13 for driving the vibrating screen. The air inlet 18 is located at the bottom of the lower housing 2 of the nebulizer. An air intake baffle 3, a baffle bracket 4, and the air switch 5 are all located at the air inlet 18 at the bottom of the lower housing 2 of the nebulizer. The air intake baffle 3, mounted on the baffle bracket 4, is a one-way air intake device. The air sensor switch 5 is mounted below the baffle bracket 4 and senses changes in airflow. The MCU control unit 11 is installed inside the upper housing 9 of the nebulizer and is electrically connected to the air switch 5 and the vibrating screen nebulizer 6. The indicator light 13 for driving the vibrating screen is mounted on the MCU control unit 11.

[0054] The power supply unit includes a power connector 19, a switch 14, and a power indicator light 12. All three components are mounted on the upper housing 9 of the atomizer and are electrically connected to the MCU control unit 11. Specifically, the power connector 19 is a Micro USB port and can be connected to the power cord 15 for power supply.

[0055] The suction component is the mouthpiece 1.

[0056] The lower housing 2 of the atomizer has a mouthpiece interface 17 on its side wall, and the mouthpiece 1 is detachably connected to the lower housing 2 of the atomizer via the mouthpiece interface 17. The chamfer radius at the connection between the lower housing 2 of the atomizer and the mouthpiece interface 17 is 5-20mm.

[0057] The working process of the atomizing inhalation device described in this invention is as follows:

[0058] Add the specified dose of medication to the medication storage bottle 16 inside the upper housing 9 of the nebulizer. Connect the power supply via the Micro USB port 19 and press the switch 14 to illuminate the power indicator 12. The user inhales through the mouthpiece 1. The airflow passes through the air switch 5, activating the MCU control unit 11, which then drives the vibrating screen nebulizer 6 to spray the atomized medication and illuminates the top driving indicator light 13 for the vibrating screen. When the MCU control unit 11 detects a weakening or disappearance of the airflow signal, it stops driving the vibrating screen 6 and the indicator light 13.

[0059] The vibrating screen atomizer 6 is made of piezoelectric ceramic elements and vibrating screen plates bonded together. The piezoelectric ceramic elements can drive the vibration of the vibrating screen plates. The MCU control unit 11 is electrically connected to the piezoelectric ceramic elements.

[0060] Example 2

[0061] The effect of atomizers with different chamfer diameters between the lower housing and the mouthpiece interface on atomization performance.

[0062] Experimental group: Vibrating screens made of stainless steel were selected and assembled into atomizers with diameters of 10mm, 15mm, 20mm, and 30mm, and chamfer radii R of 5mm, 10mm, 20mm, 30mm, and 40mm at the connection between the lower shell of the atomizer and the mouthpiece interface.

[0063] Model drug: Recombinant novel coronavirus vaccine (adenovirus type 5 vector) liquid formulation (CanSino Biologics Inc.) ).

[0064] Specifications: 0.5mL per bottle, containing 5 × 10⁶ recombinant replication-defective human adenovirus type 5 expressing the novel coronavirus S protein. 10 VP.

[0065] Breathing simulator: BRS 200i

[0066] Experimental Procedure: The breathing mode was set to adult mode. 0.5 mL of vaccine solution was added to the nebulizer's reservoir. Nebulization was started. The vaccine aerosol generated by the nebulizer was collected onto the matching glass fiber filter membrane via the breathing simulator. Virus particles on the filter membrane were eluted with elution buffer. The VP concentration of the elution buffer was detected by ELISA. The total number of virus particles adsorbed by the glass fiber filter membrane was calculated to investigate the delivery rate and total delivery volume of Ad5-nCoV after nebulization. Table 1 shows the values ​​for delivery rate and total delivery volume for different chamfer radii between the nebulizer and the mouthpiece.

[0067] Table 1

[0068]

[0069]

[0070] The results show that:

[0071] Based on the results of testing the delivery rate and total amount of 0.5ml of vaccine, when the chamfer radius R between the lower shell of the nebulizer and the nebulizer nozzle is 10 to 40mm, a higher delivery rate and total amount can be achieved, resulting in a better nebulization effect and a higher absorption rate of the nebulized drug solution by the user.

[0072] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0073] The foregoing embodiments and methods described in this invention may vary based on the capabilities, experience, and preferences of those skilled in the art.

[0074] Listing the steps of the method in a certain order in this invention does not constitute any restriction on the order of the method steps.

Claims

1. A nebulizer inhalation device that allows for instant atomization and inhalation, characterized in that, It includes an upper shell, a lower shell, a drug storage component, a drug delivery control component, an atomizing component, and a power supply component; The drug storage component is disposed inside the upper housing and is used to supply liquid medicine to the atomizing component; the drug storage component is located above the atomizing component; The atomizing component is disposed between the upper and lower housings and is used to atomize the liquid medicine provided by the drug storage component; The drug delivery control component is used to control the operation of the nebulizer component; the drug delivery control component includes an air inlet, an air switch that senses airflow, and a control unit; an air inlet is provided at the bottom of the lower housing; the air switch is located at the air inlet, and the control unit receives the signal from the air switch and controls the nebulizer component to start or stop according to the signal; The power supply component is used to supply power to the drug delivery control component and the nebulization component; The upper part of the lower housing is provided with a channel for discharging the liquid medicine after it has been atomized by the atomizing component, and the channel and the air inlet are arranged opposite to each other in the vertical direction of the lower housing; The lower housing has a horizontally arranged suction nozzle interface on its side, and the suction nozzle interface is located between the air inlet and the channel; the connection between the lower housing and the suction nozzle interface is rounded, and the chamfer radius of the rounded corner is 10-40mm.

2. The instant atomization and inhalation nebulizer according to claim 1, characterized in that, The drug storage assembly includes a liquid storage bottle.

3. The instant atomization and inhalation nebulizer according to claim 1, characterized in that, The atomizing assembly includes a vibrating screen atomizer, which is disposed between the upper housing and the lower housing.

4. The instant atomization and inhalation nebulizer according to claim 3, characterized in that, The drug delivery control assembly further includes an air inlet baffle and a baffle bracket. The air inlet baffle and the baffle bracket are disposed at the air inlet. The air inlet baffle is mounted on the baffle bracket, and the air switch is mounted below the baffle bracket.

5. The instant atomization and inhalation nebulizer according to claim 1, characterized in that, The power supply component includes a power connector or power cord, and is electrically connected to the drug delivery control component and the nebulization component to supply power to the drug delivery control component and the nebulization component.

6. The instant atomization and inhalation nebulizer according to claim 1, characterized in that, The atomizing inhalation device also includes an inhalation component, which is a mouthpiece, and the mouthpiece is connected to a mouthpiece interface.

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