A composition, its preparation and use

Abstract

The application belongs to the technical field of food and health food, and discloses a composition, a preparation method and application thereof. The composition is composed of pueraria extract, kudzu vine tea extract, artichoke extract, jujube seed extract, tuckahoe extract, hericium erinaceus extract and sugar alcohol. The pueraria extract, kudzu vine tea extract, artichoke extract, jujube seed extract, tuckahoe extract and hericium erinaceus extract are selected as raw materials, and the six raw materials are compounded with erythritol or xylitol, and further prepared into the composition by the spray granulation method. The composition has the advantages of good instant effect, less excipients, high bioavailability, low cost, difficult extraction of the extract to form a mass, and no wall sticking, and has the functions of accelerating alcohol metabolism, auxiliary protection of chemical liver damage, and nourishing and protecting the stomach.

Description

Technical Field

[0001] This invention belongs to the field of food and health food technology, and relates to a composition, its preparation method and application. Background Technology

[0002] Excessive alcohol consumption can damage organs such as the gastrointestinal tract, liver, and cardiovascular system, causing significant harm to the central nervous system, liver system, and reproductive system. Alcohol is oxidized in the liver by alcohol dehydrogenase to acetaldehyde, which is further oxidized by aldehyde dehydrogenase to non-toxic acetic acid. Acetic acid is then metabolized into carbon dioxide and water. However, many people lack aldehyde dehydrogenase, making it impossible to break down acetaldehyde in time. When acetaldehyde enters the bloodstream, it can cause damage to vital organs and functions. To reduce the occurrence of such problems, many researchers are focusing on developing products that help alleviate hangovers and protect the stomach, thus safeguarding people's health.

[0003] Kudzu root is a substance that is both food and medicine, and is the dried root of the perennial vine *Pueraria lobata*, a legume. From the perspective of traditional Chinese medicine, kudzu root has the effects of dispersing fever, promoting rash eruption, generating fluids and quenching thirst, raising yang and stopping diarrhea, and detoxifying alcohol. Kudzu root was first recorded in the *Shennong Bencao Jing* (Shennong's Classic of Materia Medica) and has been listed as a specific medicine for relieving hangovers in traditional Chinese medicine since ancient times. The main components of kudzu root that relieve hangovers, besides puerarin, total flavonoids, and polysaccharides, also include kudzu polypeptides, daidzein, and their derivatives; its main mechanisms include inhibiting alcohol absorption, accelerating alcohol metabolism, antioxidant effects, protecting liver and myocardial cells, and neuroprotective effects.

[0004] Vine tea is the dried tender shoots and leaves of *Ampelopsis grossedentata*, a plant belonging to the genus *Ampelopsis* in the family Vitaceae. Modern pharmacological studies have shown that vine tea has a protective effect on the liver, including improving acute liver injury, alcoholic liver injury, and immune-mediated liver injury. Its mechanism may be related to increasing the activity of antioxidant enzymes in liver tissue and reducing serum transaminase and lipid peroxidation levels. The active components of vine tea include flavonoids, polyphenols, polysaccharides, and trace elements, among which flavonoids are the most important active components, especially dihydromyricetin, whose pharmacological effects are most clearly defined. Studies have confirmed that dihydromyricetin possesses multiple pharmacological effects, including antioxidant, antitumor, anti-inflammatory, alcohol-relieving and liver-protective, antimicrobial, and lipid-regulating properties.

[0005] Artichokes are perennial herbaceous plants belonging to the genus *Cirsium* in the family Asteraceae. Native to the Mediterranean coast of Europe, they are an ancient plant used for both medicinal and culinary purposes. Artichokes are extremely nutritious, earning them the reputation of "King of Vegetables," and are known as the "Vegetable of the Rich" and "The Most Nutritious Natural Vegetable," sold as a high-end vegetable in the international market. Artichokes mainly contain flavonoids, sesquiterpene lactones, phenols, lignans, and other functional components. Studies have shown that artichoke extract also has detoxifying and hangover-relieving effects, can repair damaged liver cells, and has a certain therapeutic effect on liver damage caused by alcohol.

[0006] Hovenia dulcis Thunb. is the dried mature seed of Hovenia acerba Lindl. of Rhamnaceae. From the perspective of traditional Chinese medicine, Hovenia dulcis Thunb. has the effects of promoting water excretion and relieving edema. Hovenia dulcis Thunb. contains flavonoids, such as kaempferol, apigenin, myricetin, quercetin, hydrogen myricetin, and anthraquinones, such as emodin. It has the effects of resisting lipid peroxidation and protecting liver damage. Studies have shown that Hovenia dulcis Thunb. has the effects of relieving alcohol, protecting liver, resisting liver fibrosis, resisting aging, and resisting fatigue.

[0007] Poria cocos is the dried sclerotium of Poria cocos of the family of polyporaceae, which is a common traditional Chinese medicine with both medicinal and edible functions. Modern research has found that the chemical components of Poria cocos mainly include polysaccharides, triterpenes, and sterols, which have the pharmacological effects of promoting water metabolism, regulating gastrointestinal function, sedation, anti-tumor, and liver protection. Modern research shows that Poria cocos polysaccharide has a certain protective effect on acute gastric mucosal damage caused by alcohol.

[0008] Hericium erinaceus belongs to the Basidiomycota, Agaricomycetes, Russulales, and Hericiaceae, and is a precious fungus with both medicinal and edible functions. It has a long history of being used as food and medicine in China. H. erinaceus not only has high nutritional value, but also contains many active ingredients in its mycelium and fruiting body, which have physiological functions such as antioxidant, anti-tumor, anti-aging, immune enhancement, gastric mucosa protection, and neuroprotection. H. erinaceus polysaccharide is one of the most studied active ingredients of H. erinaceus. Modern pharmacological research shows that H. erinaceus polysaccharide has good inhibitory effects on gastritis and gastric mucosal damage.

[0009] Invention patent CN113142365A discloses a kind of alcohol-protecting liver and stomach-protecting tablet candy, including sorbitol, kudzu tea instant powder, microcrystalline cellulose, corn oligopeptide, malt dextrin, small chrysanthemum powder, yeast extract, synergist and magnesium stearate raw materials. CN105287940A discloses a kind of alcohol-protecting beverage, including the following raw materials: hawthorn fruit extract, radix puerariae extract, kudzu flower extract, hovenia dulcis Thunb. extract, kudzu tea extract, mint extract, licorice extract, tea polyphenol, stevioside and citric acid.

[0010] CN114098059A discloses a kind of alcohol-protecting liver and oral instant composition and its preparation method and preparation equipment, wherein the alcohol-protecting liver and oral instant composition includes radix puerariae, Hovenia dulcis Thunb., turmeric, black ginseng, fruit powder, sugar alcohol, starch, acidity regulator, sweetener, binder and essence, although it has a certain instant effect, but adds various auxiliary materials, increases the cost, and reduces the content of effective substances under the same specification. Further, the mixing of plant extracts in the prior art is mainly through mechanical mixing according to a certain ratio. The mixture obtained by this method has strong hygroscopicity and is easy to form clumps. Generally, the extract powder is fine and easy to generate dust, and the equipment is not easy to clean. In order to solve the problems of moisture absorption and dust, further addition of various auxiliary materials is required. In summary, these schemes have many auxiliary material components and large amount, which will affect the use effect to some extent and increase the usage amount.

[0011] At the same time, the existing alcoholism products are mostly in the form of tablets, hard capsules, liquid beverages and the like, which are inconvenient for consumers to use. For example, tablets need to add more auxiliary materials, and the tablet specification is large, and the cost is increased accordingly; it is relatively difficult for some people to swallow hard capsules; liquid beverages occupy a large space and are inconvenient to carry.

[0012] Therefore, it is urgent to develop a composition with low cost, instant property, non-wall sticking, good fluidity, not easy to dust, high bioavailability, and less auxiliary materials. SUMMARY

[0013] In order to solve the technical problems of poor instant property, multiple types of auxiliary materials, high cost, insufficient bioavailability, easy agglomeration of extract, easy dusting and difficult cleaning of equipment of the existing alcoholism and stomach protection products, the purpose of the present application is to provide a composition and a preparation method and application thereof.

[0014] In order to achieve the above-mentioned purpose, the present application adopts the following technical scheme:

[0015] The present application provides a composition, which is composed of plant extracts and fillers.

[0016] Further, the plant extracts are Pueraria lobata extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis fruit extract, Poria cocos extract and Hericium erinaceus extract.

[0017] Further, the filler is a sugar alcohol.

[0018] Further, the sugar alcohol is erythritol or xylitol.

[0019] Further, the composition is composed of the following raw materials in parts by weight: Pueraria lobata extract 20-40 parts, Ampelopsis grossedentata extract 5-20 parts, Cynara scolymus extract 1-6 parts, Hovenia dulcis fruit extract 1-6 parts, Poria cocos extract 1-6 parts, Hericium erinaceus extract 1-6 parts, and sugar alcohol 40-60 parts.

[0020] Further, the sugar alcohol is erythritol.

[0021] Further, the mass ratio of the Pueraria lobata extract, Poria cocos extract and Hericium erinaceus extract in the composition is 27-33:1-6:1-3.

[0022] Further, the mass ratio of the Pueraria lobata extract, Poria cocos extract and Hericium erinaceus extract in the composition is 27:1:2.

[0023] The present application also provides a preparation method of the composition, characterized by comprising the following steps:

[0024] (1) mixing Pueraria lobata extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis extract, Poria cocos extract and Hericium erinaceus extract with sugar alcohol;

[0025] (2) spray drying and granulating the mixture obtained in step (1) with water as the binder to obtain the composition.

[0026] Further, the process conditions for the spray drying and granulating in step (2) are as follows: inlet air temperature 60-90 DEG C, chamber temperature 40-70 DEG C, fan frequency 18-28 Hz, flow rate 180-220 mL / min, and atomization pressure 0.2-0.5 MPa.

[0027] Further, the mass fraction of the composition particles with a particle size of 40 mesh or less in the total particles is not less than 95%, and the mass fraction of the particles with a particle size of 40-100 mesh in the total particles is not less than 70%.

[0028] Further, the Pueraria lobata extract is extracted with water for 2 times with 6-10 times the amount of water, the Ampelopsis grossedentata extract is extracted with water for 2 times with 8-12 times the amount of water, the Cynara scolymus extract is extracted with water for 2 times with 8-12 times the amount of water, the Hovenia dulcis extract is extracted with water for 2 times with 8-12 times the amount of water, the Poria cocos extract is extracted with water for 2 times with 4-8 times the amount of water, and the Hericium erinaceus extract is extracted with water for 2 times with 6-10 times the amount of water.

[0029] The application further provides the use of the composition in the preparation of food, health food and medicine.

[0030] Further, the food, health food and medicine further contain one or more of an acidity regulator, a sweetener and a food flavoring.

[0031] Further, the acidity regulator is at least one selected from the group consisting of citric acid, malic acid, tartaric acid and sodium citrate.

[0032] Further, the sweetener is at least one selected from the group consisting of stevioside, mogroside, acesulfame potassium, chloro sucrose and abbas sweetener.

[0033] Further, the food flavoring is at least one selected from the group consisting of lemon flavoring, coffee flavoring, brown sugar flavoring, black tea flavoring, litchi flavoring and mint flavoring.

[0034] Further, the food, health food and medicine prepared according to the method of the application have a quick-dissolving property.

[0035] The application further provides the use of the composition in the preparation of alcohol-dissolving and stomach-protecting products.

[0036] The application has the following beneficial effects:

[0037] The present application selects Pueraria extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis Thunb extract, Poria cocos extract and Hericium erinaceus extract as raw materials, and through scientific compounding of erythritol or xylitol with each extract raw material, the synergistic effect of plant extract components and erythritol or xylitol is achieved, the composition has instant properties, good dispersibility, can be quickly dispersed in artificial saliva and water, and is not sticky to teeth, the composition has simple excipients, avoids problems such as low effective substance content, high product cost and more product excipients under the same specification, and the composition has the effects of accelerating alcohol metabolism, auxiliary protection function on chemical liver injury, nourishing stomach and protecting stomach.

[0038] The present application further uses a spray granulation process to prepare the composition, and has the advantages of good bag compliance and high production efficiency.

[0039] The preparation processing technology of the present application can be applied to other types of compositions, and provides new choices and ideas for the preparation processing technology. BRIEF DESCRIPTION OF DRAWINGS

[0040] Figure 1 In order to add artificial saliva to the cuvette, the contrast chart of erythritol and pre-gelatinized starch dissolved in artificial saliva at 10s, wherein A is the chart of erythritol dissolved in artificial saliva at 10s, B is the contrast chart of pre-gelatinized starch dissolved in artificial saliva at 10s, and the dissolution temperature is 37℃±2℃.

[0041] Figure 2 In order to add artificial saliva to the cuvette, the contrast chart of "Example 6" and "Comparative Example 5-17" dissolved in artificial saliva at 11.5s, wherein A is the chart of "Example 6" dissolved in artificial saliva at 11.5s, B is the chart of "Comparative Example 5-17" dissolved in artificial saliva at 11.5s, and the dissolution temperature is 37℃±2℃. DETAILED DESCRIPTION

[0042] The embodiments of the present application will be described in detail below with specific specific examples, and those skilled in the art can easily understand other advantages and effects of the present application from the disclosure of the present specification. The present application can also be implemented or applied by different specific embodiments, and various modifications or changes can be made to the details in the specification without departing from the spirit of the present application.

[0043] Before further describing the specific embodiments of the present application, it should be understood that the protection scope of the present application is not limited to the following specific embodiments; it should also be understood that the terms used in the embodiments of the present application are for describing the specific embodiments, and are not intended to limit the protection scope of the present application.

[0044] When the embodiments give numerical ranges, it is to be understood that every numerical range encompassing the two endpoints, and any number subsumed therein, is contemplated unless otherwise indicated. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0045] Unless otherwise specified, the raw materials used in the present application are all commercially available in the art.

[0046] Embodiments

[0047] A composition comprising the following raw materials: Pueraria lobata extract 20-40 parts, Ampelopsis grossedentata extract 5-20 parts, Cynara scolymus extract 1-6 parts, Hovenia dulcis extract 1-6 parts, Poria cocos extract 1-6 parts, Hericium erinaceus extract 1-6 parts, and sugar alcohol 40-60 parts.

[0048] The Pueraria lobata extract is extracted with water for 2 times with 8 times the amount of water; the Ampelopsis grossedentata extract is extracted with water for 2 times with 10 times the amount of water; the Cynara scolymus extract is extracted with water for 2 times with 10 times the amount of water; the Hovenia dulcis extract is extracted with water for 2 times with 10 times the amount of water; the Poria cocos extract is extracted with water for 2 times with 6 times the amount of water; and the Hericium erinaceus extract is extracted with water for 2 times with 8 times the amount of water.

[0049] The formulation of the composition of embodiments 1-8 is shown in Table 1.

[0050] Table 1

[0051]

[0052] Embodiment 9

[0053] The difference from embodiment 6 is that the type of filler is different; specifically, xylitol is used instead of erythritol.

[0054] The preparation method of the composition of embodiments 1-9 is as follows:

[0055] (1) Mix the Pueraria lobata extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis extract, Poria cocos extract, and Hericium erinaceus extract, and sugar alcohol according to the formulation amount;

[0056] (2) Take the mixture obtained in step (1) as the binder, and perform granulation by the spray granulation method, so that the granules with a particle size of 95% or more pass through a 40-mesh sieve, and the proportion of 40-mesh-100-mesh is 70% or more, to obtain the composition.

[0057] The process conditions for spray drying and granulation are as follows: inlet air temperature 70°C, chamber temperature 55°C, fan frequency 20Hz, flow rate 190mL / min, and atomization pressure 0.25MPa.

[0058] Comparative Example 1

[0059] The difference between this comparative example and Example 6 is that the plant extract does not contain Pueraria lobata extract.

[0060] Comparative Example 2

[0061] The difference between this comparative example and Example 6 is that the plant extract does not contain Poria cocos extract.

[0062] Comparative Example 3

[0063] The difference between this comparative example and Example 6 is that the plant extract does not contain Hericium erinaceus extract.

[0064] Comparative Example 4

[0065] The difference between this comparative example and Example 6 is that the amount of Pueraria lobata extract is 45 parts by weight, the amount of Poria cocos extract is 12 parts by weight, and the amount of Hericium erinaceus extract is 8 parts by weight.

[0066] Comparative Example 5

[0067] The difference between this comparative example and Example 6 is that the type of filler is different; see Table 2 for details.

[0068] Table 2

[0069]

[0070]

[0071] Comparative Example 6

[0072] The difference between this comparative example and Example 6 is that the amount of erythritol is 67 parts by weight.

[0073] Comparative Example 7

[0074] The difference between this comparative example and Example 6 is that the amount of erythritol is 33 parts by weight.

[0075] Comparative Example 8

[0076] The difference between this comparative example and Example 6 is that the granulation process is different; specifically, the granulation process is to simply mix the composition raw materials with erythritol by mechanical means (mixing speed is 8 r / min, mixing time is 30 min).

[0077] Comparative Example 9

[0078] The difference between this comparative example and Example 6 is that the granulation process is different; specifically, the composition raw materials and erythritol are dry granulated and dried (feed rate 10 r / min, extrusion speed 15 r / min, granulation speed 70 r / min, dry compression wheel temperature 20°C, cooling water temperature 10°C).

[0079] Comparative Example 10

[0080] The difference between this comparative example and Example 6 is that the granulation process is different; specifically, the composition raw materials and erythritol are dry granulated and dried (feed rate 10 r / min, extrusion speed 15 r / min, granulation speed 70 r / min, dry compression wheel temperature 20°C, cooling water temperature 10°C).

[0081] Comparative Example 11

[0082] The difference between this comparative example and Example 6 is that the particle size of the granules obtained by spray granulation is different; specifically, the control parameter condition is that the proportion of particles less than 95% passing through a 40-mesh sieve is less than 70%.

[0083] Comparative Example 12

[0084] The difference between this comparative example and Example 6 is that the particle size of the granules obtained by spray granulation is different; specifically, the control parameter condition is that the proportion of particles less than 95% passing through a 40-mesh sieve is less than 70%.

[0085] Comparative Example 13

[0086] The difference between this comparative example and Example 6 is that the type of binder is different; specifically, the binder is sodium carboxymethyl cellulose.

[0087] Comparative Example 14

[0088] The difference between this comparative example and Example 6 is that the type of binder is different; specifically, the binder is hydroxypropyl methyl cellulose.

[0089] Comparative Example 15

[0090] The difference between this comparative example and Example 6 is that it does not contain erythritol and is composed only of plant extracts.

[0091] Comparative Example 16

[0092] Prepared according to the example in CN114098059A.

[0093] Effect performance test

[0094] I. Evaluation of the physical and chemical properties of the wine-sobering preparation

[0095] 1. Experimental method

[0096] 1.1 Dissolution time, caking phenomenon and wall sticking evaluation

[0097] Examples 1-9 and Comparative Examples 1-7, Comparative Example 16 were evaluated in terms of dissolution time, caking phenomenon and wall sticking.

[0098] 1.2 Comprehensive evaluation of human groups

[0099] The compositions prepared in Examples 1-9 and Comparative Example 1-10 were selected for 20 sensory evaluation personnel, and the "instant effect", "wall sticking" and "taste" were used as evaluation indexes for weight calculation and comprehensive score.

[0100] Weight ratio and score distribution:

[0101] ① The instant effect accounted for 60%, with a score of 0-10, 10 for good instant effect and 0 for poor effect;

[0102] ② Wall sticking accounted for 25%, with a score of 0-10, 10 for weak wall sticking and 0 for strong wall sticking;

[0103] ③ Taste accounted for 15%, with a score of 0-10, 10 for good taste and 0 for poor taste;

[0104] Comprehensive score = 60% instant effect + 25% wall sticking + 15% taste.

[0105] 1.3 Granulation time and granulation effect evaluation

[0106] Examples 1-8, Comparative Examples 1-4, Comparative Examples 6-7 and Comparative Example 15 were evaluated in terms of "granulation time" and "granulation effect".

[0107] 1.4 Evaluation of hygroscopicity experiment, bag compliance and qualified production speed

[0108] The critical relative humidity and rest angle of the compositions described in Examples 6 and 9 and Comparative Examples 8-10 were determined, and their bag compliance and qualified production speed were noted for evaluation.

[0109] 1.5 Process compliance and qualified production speed evaluation

[0110] The process compliance and qualified production speed of the compositions described in Examples 6, Comparative Example 11 and Comparative Example 12 were investigated, and the effects of particle size distribution were compared.

[0111] 1.6 Evaluation of equipment wall sticking, granulation effect and flowability

[0112] The equipment wall sticking, granulation effect and flowability (characterized by rest angle) of the compositions described in Examples 6, Comparative Example 13 and Comparative Example 14 were investigated.

[0113] 2. Experimental results

[0114] 2.1 Evaluation of dissolution time, caking phenomenon and wall sticking

[0115] The results of dissolution time, caking phenomenon and wall sticking of Examples 1-9 and Comparative Examples 1-7 and Comparative Example 16 are shown in Table 3.

[0116] The dissolution time of Examples 1-9 is short, ranging from 11.5 seconds to 12.7 seconds, and especially Example 6 is the best, with a dissolution time of 11.5 seconds, and the best instant effect; the dissolution time of the comparative examples is long, and especially Comparative Example 5-2 has the longest dissolution time of 26.5 seconds, and the worst instant effect.

[0117] Examples 1-9, Comparative Examples 1-4, Comparative Examples 6-7 use a single sugar alcohol, and no caking phenomenon occurs, and Comparative Example 5 has a caking phenomenon, and especially Comparative Example 5-2 has more caking.

[0118] Comparative Example 5-2 has more wall sticking, and Comparative Example 5-3 uses resistant dextrin and Comparative Example 5-4 uses corn starch, which has slight wall sticking, and the rest of the examples and comparative examples have no wall sticking.

[0119] Table 3

[0120]

[0121]

[0122] Figure 1 Figure A is the dissolution of erythritol in artificial saliva at 10s, Figure 1 Figure B is the dissolution of pregelatinized starch in artificial saliva at 10s, and the dissolution temperature is 37℃±2℃. It can be seen from the figure that erythritol can be quickly dissolved and clarified in artificial saliva, while pregelatinized starch cannot be quickly dissolved and clarified.

[0123] Figure 2 Figure A is the dissolution of Example 6 in artificial saliva at 11.5s, Figure 2 Figure B is the dissolution of Comparative Example 5-17 in artificial saliva at 11.5s, and the dissolution temperature is 37℃±2℃. Figure 2 It can be seen from the figures that the instant effect of erythritol and extract spray granulation is good, and the dissolution speed of resistant dextrin, corn starch, erythritol and extract mixture after spray granulation is not as good as that of pure erythritol.

[0124] 2.2 Comprehensive evaluation of the population

[0125] The evaluation results of the instant effect, wall sticking feeling and mouthfeel are shown in Table 4. It can be seen from the table that the comprehensive scores of Examples 1-9 are high, ranging from 8.66 to 9.17, especially that of Example 6 is the highest, being 9.17. The comprehensive scores of Comparative Examples 1-10 are low, ranging from 4.97 to 8.58, especially that of Comparative Example 8 is the lowest, being 4.97.

[0126] Table 4

[0127]

[0128]

[0129] (Note: The lower score of mouthfeel is because the flavoring auxiliary is not added yet)

[0130] 2.3 Evaluation of granulation time and granulation effect

[0131] Examples 1-8, Comparative Examples 1-4, Comparative Examples 6-7 and Comparative Example 15 are evaluated with "granulation time" and "granulation effect" as indexes. The results are shown in Table 5, which shows that the granulation time of Examples 1-8 is relatively short, ranging from 130 to 140 min, and the granulation effect is good; the granulation effect of Comparative Examples 4 and 6 is slightly poor; in comparison, the granulation time of Comparative Examples 1-3 and 7 is long, and the granulation effect is poor; Comparative Example 15 cannot be granulated into a shape, and the effect is the worst.

[0132] Table 5

[0133] Granulation time (min) Granulation effect Example 1 134 Good Example 2 135 Good Example 3 132 Good Example 4 131 Good Example 5 138 Good Example 6 137 Good Example 7 135 Good Example 8 140 Good Comparative Example 1 167 Poor Comparative Example 2 165 Poor Comparative Example 3 162 Poor Comparative Example 4 154 Fairly poor Comparative Example 6 145 Fairly poor Comparative Example 7 158 Poor Comparative Example 15 / Could not be granulated, poor effect

[0134] 2.4 Evaluation of hygroscopicity experiment, bag compliance and qualified production speed of bag

[0135] The hygroscopicity results of the granules prepared by different process treatment methods are shown in Table 6, which shows that:

[0136] (1) The hygroscopicity of the granules prepared in Example 6 is relatively the lowest, and the rest angle is the smallest among all the investigated schemes; followed by Example 9; the hygroscopicity of Comparative Examples 8-10 is relatively high and the rest angle is relatively large, and the flowability is poor.

[0137] (2) The bag compliance of Example 6 is good, and the production efficiency is high; followed by Example 9; the bag compliance of Comparative Examples 8-10 is poor, and the bag speed is slow or even the bag is unsuccessful.

[0138] Table 6

[0139]

[0140] 2.5 Evaluation of process compliance and qualified production speed of bag

[0141] The influence of different particle sizes on the granulation composition is shown in Table 7, and the results show that:

[0142] (1) Comparative Example 11, the coarse particles are more, and when bagging the finished product, the material is prone to blockage and unsmooth discharging, affecting the production speed; the overall taste is not good, the particles are relatively coarse, the dissolution is relatively slow, and the instant feeling is poor;

[0143] (2) Comparative Example 12, there are too many fine powders, and when bagging, there is much powder floating, and the air tightness of the products bagged is not good, which is unqualified products, greatly affecting the production efficiency. The fine powder sticks to the wall, and the testers have a poor experience;

[0144] (3) Example 6: The granulation composition has moderate particle size, fast dissolution, and good experience of the testers in the case of the particle size distribution.

[0145] The mass fraction of the particles with particle size greater than 40 mesh in the wine-awakening preparation particles is not less than 95%, and the mass fraction of the particles with particle size of 40 mesh-100 mesh in the wine-awakening preparation particles is not less than 70%, which has moderate particle size and good instant effect.

[0146] Table 7

[0147]

[0148] 2.6 Evaluation of equipment wall sticking, granulation effect, and fluidity

[0149] The equipment wall sticking and granulation effect of the wine-awakening preparations of Example 6 and Comparative Examples 13 and 14 are shown in Table 8, and the results show that: when the two commonly used binders, sodium carboxymethyl cellulose (Comparative Example 13) and hydroxypropyl methyl cellulose (Comparative Example 14), are applied to the composition granulation, it is found that: after the completion of the spray drying process, there is a certain degree of wall sticking in the spray tower (referring to the hollow chamber of the spray drying equipment), which is not conducive to the outflow of the material and is easy to cause uneven composition in the prepared particles and loss of effective substances; the particles prepared in Comparative Examples 13 and 14 have poor effect, have certain stickiness, have relatively large angle of repose, and have poor fluidity.

[0150] However, when water is simply used as a binder (Example 6) for granulation, the prepared particles have good effect and good fluidity, the mixture is easy to disperse, and there is no wall sticking. The composition can be prepared into good particles by using only water through the spray drying equipment.

[0151] In the spray granulation, water is only used as a binder in Example 6, and by spraying water, the polysaccharides in the Poria cocos extract and Hericium erinaceus extract and the starch in the Pueraria lobata extract are made into binders by absorbing water, so that the fine powders are aggregated and bonded into particles.

[0152] Table 8

[0153] Wall sticking of the equipment Granulation effect Angle of repose (°) Comparative Example 13 Slight Poor 39.5 Comparative Example 14 Slight Poor 40.6 Example 6 None Good 34.8

[0154] 3. Conclusion

[0155] The composition of the present application selects Pueraria extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis Thunb extract, Poria cocos extract and Hericium erinaceus extract as raw materials to form a composition with the functions of accelerating alcohol metabolism, auxiliary protection of chemical liver injury, nourishing stomach and protecting stomach. Through the compounding of erythritol or xylitol with each extract, water is preferably used as a binder, and through the spray granulation method, a composition with less excipients, good instant effect, low cost, non-clumping of extract, non-sticking wall and good taste is prepared, which provides a new idea for the development of alcoholism relieving and stomach protecting products.

[0156] The above is a further description of the present application in combination with specific embodiments, but these embodiments are only exemplary and do not constitute any limitation on the scope of the present application. Those skilled in the art should understand that the details and forms of the technical solutions of the present application can be modified or replaced without departing from the spirit and scope of the present application, and such modifications and replacements all fall within the protection scope of the present application.

Claims

1. A composition characterized in that, The composition is prepared from the following raw materials: Pueraria extract 20-40 parts, Ampelopsis grossedentata extract 5-20 parts, Cynara scolymus extract 1-6 parts, Hovenia dulcis extract 1-6 parts, Poria cocos extract 1-6 parts, Hericium erinaceus extract 1-6 parts, and sugar alcohol 40-60 parts; the sugar alcohol is erythritol or xylitol; The Pueraria extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis extract, Poria cocos extract and Hericium erinaceus extract are all prepared by water extraction process; The preparation method of the composition comprises the following steps: (1) mixing Pueraria extract, Ampelopsis grossedentata extract, Cynara scolymus extract, Hovenia dulcis extract, Poria cocos extract and Hericium erinaceus extract with sugar alcohol; (2) spray granulating the mixture obtained in step (1) with water as the binder to obtain the composition; The process conditions of the spray granulation are as follows: inlet air temperature 60-90 ℃, chamber temperature 40-70 ℃, fan frequency 18-28 Hz, flow rate 180-220 mL / min, and atomization pressure 0.2-0.5 MPa; the mass fraction of particles with a particle size of more than 40 mesh in the total particles of the composition is not less than 95%, and the mass fraction of particles with a particle size of 40 mesh-100 mesh in the total particles is not less than 70%.

2. The composition of claim 1, wherein, The mass ratio of the Pueraria extract, Poria cocos extract and Hericium erinaceus extract is 27-33:1-6:1-3.

3. Use of the composition of any one of claims 1-2 in the preparation of health-care food.

4. Use according to claim 3, characterized in that, The health-care food further contains one or more of acidity regulator, sweetener and edible essence.

5. Use according to claim 4, characterized in that, The health-care food has the property of instant dissolution.

6. Use of the composition of any one of claims 1-2 in the preparation of products for relieving alcoholism and protecting stomach.

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