Adsorption type blood purifier

Abstract

The application discloses an adsorption type blood purifier and belongs to the technical field of medical devices, which comprises a shell, wherein the shell is a tubular structure with both ends being through, end covers are arranged at both ends of the shell, a blood outlet is arranged on the end cover at the upper end of the shell, a blood inlet is arranged on the end cover at the lower end of the shell, liquid outlets are arranged at the upper end and the lower end of the side of the shell, a filter core is arranged in the shell, and the filter core can adsorb middle and large molecule toxins in blood and filter excess moisture and small molecule toxins in blood.

Description

Technical Field

[0001] This invention relates to an adsorption-type blood purifier, belonging to the field of medical device technology. Background Technology

[0002] Blood purification is a group of treatment techniques that use purification devices to remove metabolic products, abnormal plasma components, and drugs or toxins accumulated in the body through extracorporeal circulation in order to correct the disorder of the internal environment. Blood purification techniques include hemodialysis (HD), hemofiltration (HF), hemoperfusion (HP), plasma exchange (PE), etc. Among them, hemodialysis, hemofiltration, and hemodiafiltration are commonly used renal replacement techniques.

[0003] Chinese patent document CN109758631A discloses an adsorption-type hemodialysis machine, comprising a blood adsorption chamber, a hemodialysis chamber, an inlet cap, an outlet cap, sealant, a hollow fiber membrane, an adsorbent, and a separating mesh. The main body consists of the blood adsorption chamber and the hemodialysis chamber connected in series. The inlet cap and outlet cap are fixed at the top and bottom ends. The hollow fiber membrane bundle is bonded to the inside of the hemodialysis chamber by sealant. The adsorbent, made of activated carbon, adsorption resin balls, solid adsorption wires, or hollow adsorption wires, is placed inside the blood adsorption chamber. The separating mesh is used to fix the adsorbent. The patient's blood first passes through the blood adsorption chamber to adsorb harmful macromolecules, and medication and fluid replacement are administered as needed before entering the hemodialysis chamber for dialysis treatment.

[0004] Existing technologies often use an adsorber and dialyzer connected in series, resulting in a large blood chamber capacity. This can easily lead to adverse reactions such as decreased blood volume and hypotension in patients during clinical use. Furthermore, it requires a large amount of dialysate, resulting in high costs. Summary of the Invention

[0005] To address the problems existing in the prior art, the present invention provides an adsorption-type blood purifier that has both adsorption and dialysis filtration functions, and has a small blood chamber capacity, which can avoid adverse reactions such as decreased blood volume or hypotension in patients, and can achieve the purpose of treatment without the use of dialysis fluid.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: an adsorption-type blood purifier, comprising a shell, the shell being a tube extending through both ends, and end caps installed at both ends of the shell. The end caps are installed at the openings at both ends of the shell to seal the openings at both ends of the shell. A bleeding port is installed on the end cap at the upper end of the shell, and a blood inlet is installed on the end cap at the lower end of the shell. Before use, the bleeding port and the blood inlet are fitted with sealing caps. During use, blood enters the interior of the shell through the blood inlet and then exits through the bleeding port. Liquid outlets are installed at both the upper and lower ends of the side of the shell, and the liquid outlets can be connected to an external waste discharge pipe during use. A filter element is installed inside the shell. The filter element can adsorb medium and large molecular toxins in the blood and filter out excess water and small molecular toxins in the blood. Medium and large molecular toxins can be adsorbed by the filter element, while water and small molecular toxins will be discharged through the liquid outlet under the action of pressure difference.

[0007] Preferably, a filter membrane capable of secondary filtration is installed inside the upper end of the housing. The filter membrane can guide the filtered medium and large molecular toxins, allowing them to enter the interior of the filter frame. The filter frame is fixedly connected to the inner wall of the housing. Medium and large molecular toxins that have detached from the filter element will be re-adsorbed by the filter membrane.

[0008] Preferably, the filter membrane is wrapped around a mounting frame, which is arched in shape with a lower center and higher edges. Wrapping the filter membrane around the mounting frame allows the filter membrane to also maintain an arched shape with a lower center and higher edges, thereby increasing the contact area between the filter membrane and the blood. The material of the mounting frame can also undergo elastic deformation. The filter membrane is interlocked with the filter frame by the mounting frame fixedly connected to it. When too many medium and large molecular toxins adsorbed on the filter membrane affect blood flow, gaps are created between the filter membrane and the filter frame, allowing medium and large molecular viruses to enter the interior of the filter frame.

[0009] Preferably, the filter frame includes a base ring, on which an inwardly extending guide ring is fixedly connected. After the blood carries medium and large molecular toxins into the filter frame, it will move along the direction of the guide ring. A support ring is fixedly connected to the inner ring surface of the guide ring, and a filter ring is covered on the support ring. Under the guidance of the guide ring, medium and large molecular toxins and blood will flow towards the filter ring. The filter ring will adsorb medium and large molecular toxins, while the blood can smoothly pass through the filter ring and flow to the outside of the filter frame.

[0010] Preferably, the upper end of the support ring is outwardly hooked, which can prevent medium and large molecular toxins from rising along the side wall of the filter ring under the action of impact and thus flowing back out of the filter frame.

[0011] Preferably, the filter element is made of a porous water-insoluble polymer, and the filter element has multiple through holes for blood cells to pass through.

[0012] Preferably, the number of central channels in the filter element is 5,000-25,000;

[0013] The inner diameter of the central channel of the filter element is 150-250 μm.

[0014] Preferably, the average pore size of the internal pore structure of the filter element is 2-50 nm;

[0015] The specific surface area of ​​the filter element is 100-1200 m². 2 / g.

[0016] Preferably, the interior of the housing is provided with a preservation solution for keeping the filter element moist for a long time. The preservation solution is 0.9% sodium chloride injection or water for injection, preferably 0.9% sodium chloride injection. The preservation solution can keep the filter element moist during storage, making it convenient to take out and use.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] 1. A filter membrane is installed inside the upper part of the shell for secondary filtration, which can prevent excessive adsorption of medium and large molecular toxins in the filter element, which would cause the medium and large molecular toxins to detach from the filter element and re-enter the patient's body with the blood.

[0019] 2. The filter membrane is designed in an arc shape, which can guide the medium and large molecular toxins being filtered, causing them to be flushed into the interior of the filter frame without affecting the filtration effect.

[0020] 3. The filter frame consists of a support ring and a filter ring. The support ring is designed with an outer slope that is higher than the inner slope, which can guide the blood entering the filter frame. At the same time, under the action of pressure difference, the blood entering the filter frame can flow out better, while the filter ring will retain medium and large molecular toxins inside the filter frame. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the structure of the present invention.

[0022] Figure 2 This is a cross-sectional view of the present invention.

[0023] Figure 3 For the present invention Figure 2 Enlarged view of point A.

[0024] Figure 4 This is an exploded view of the filter membrane and mounting frame of the present invention.

[0025] In the diagram: 1. Shell, 2. End cap, 3. Bleeding port, 4. Blood inlet, 5. Liquid outlet, 6. Filter element, 7. Filter membrane, 8. Filter frame, 801. Base ring, 802. Guide ring, 803. Support ring, 804. Filter ring, 9. Mounting bracket. Detailed Implementation

[0026] The present invention is illustrated below with specific embodiments, but these are not intended to limit the invention.

[0027] In this embodiment, an adsorption-type blood purifier is provided, such as... Figure 1 and Figure 2 As shown, the device includes a housing 1, which is a tubular structure extending through both ends. End caps 2 are installed at both ends of the housing 1, sealing the openings. A bleeding port 3 is installed on the upper end cap 2, and a blood inlet 4 is installed on the lower end cap 2. Before use, sealing caps are installed on both the bleeding port 3 and the blood inlet 4 to seal them. During use, the sealing caps are opened, allowing blood to enter the housing 1 through the blood inlet 4 and exit through the bleeding port 3. The blood flows from top to bottom inside the housing 1. After filtration, blood remains inside the housing 1 and the tubing. This can lead to blood loss in patients. In this case, saline solution can be introduced into the interior of the housing 1 through the blood inlet 4 to push the residual blood in the housing 1 and the tubing into the patient's body, thus preventing excessive blood loss. The upper and lower ends of the side of the housing 1 are equipped with outlets 5. Before use, the outlets 5 are also equipped with sealing caps. During use, the outlets 5 can be connected to the external waste discharge pipe. The interior of the housing 1 is equipped with a filter element 6. The filter element 6 can adsorb medium and large molecular toxins in the blood and filter out excess water and small molecular toxins in the blood. Medium and large molecular toxins can be adsorbed by the filter element 6, while water and small molecular toxins will be discharged through the outlets 5 under the action of pressure difference.

[0028] To prevent excessive amounts of medium and large molecular weight toxins from detaching from filter element 6 and re-entering the patient's body due to the force of the blood and subsequent saline solution, such as... Figure 3 and Figure 4 As shown, a filter membrane 7 capable of secondary filtration is installed inside the upper end of the housing 1. The filter membrane 7 can guide the filtered medium and large molecular toxins, allowing them to enter the interior of the filter frame 8. The filter frame 8 is fixedly connected to the inner wall of the housing 1. The medium and large molecular toxins that have detached from the filter element 6 will be re-adsorbed by the filter membrane 7 and will move along the filter membrane 7 into the interior of the filter frame 8 under the force of the blood flow. This can prevent the medium and large molecular toxins adsorbed on the filter membrane 7 from affecting the blood flow through the filter membrane 7.

[0029] The filter membrane 7 is wrapped around the mounting frame 9, which is arched in shape with a lower center and higher edges. Wrapping the filter membrane 7 around the mounting frame 9 allows the filter membrane 7 to also maintain an arched shape with a lower center and higher edges, thereby increasing the contact area between the filter membrane 7 and the blood, resulting in better filtration. Moreover, the arched shape of the filter membrane 7 can better filter medium and large molecular toxins. The mounting frame 9 is made of medical-grade rubber and can be elastically deformable. The filter membrane 7 is interlocked with the filter frame 8 by the mounting frame 9 fixedly connected to it. When too many medium and large molecular toxins are adsorbed on the filter membrane 7, affecting blood flow, the pressure of the blood on the mounting frame 9 will increase, thereby causing the mounting frame 9 to elastically deform. This creates a gap between the filter membrane 7 and the filter frame 8, allowing medium and large molecular viruses to smoothly enter the interior of the filter frame 8.

[0030] The filter frame 8 includes a base ring 801, on which an inwardly extending guide ring 802 is fixedly connected. After blood carries medium and large molecular toxins into the filter frame 8, it moves along the direction of the guide ring 802. A support ring 803 is fixedly connected to the inner ring surface of the guide ring 802, and a filter ring 804 is covered on the support ring 803. Under the guidance of the guide ring 802, medium and large molecular toxins and blood flow towards the filter ring 804. The filter ring 804 adsorbs medium and large molecular toxins, while the blood can smoothly pass through the filter ring 804 and flow to the outside of the filter frame 8. At the same time, the blood flow velocity outside the filter frame 8 is greater than that inside the filter frame 8, creating a pressure difference between the inside and outside of the filter frame 8, thereby improving the filtration effect of the filter ring 804.

[0031] The upper end of the support ring 803 is outwardly hooked. The outward hook shape can prevent medium and large molecular toxins from rising along the side wall of the filter ring 804 under the action of impact and thus flowing back out of the filter frame 8.

[0032] The filter element 6 is made of a porous water-insoluble polymer and has multiple through holes for blood cells to pass through.

[0033] The filter element 6 has 5,000-25,000 central channels, preferably 10,000-15,000.

[0034] The inner diameter of the central channel of the filter element 6 is 150-250um, preferably 200um;

[0035] The average pore size of the internal pore structure of the filter element 6 is 2-50nm, preferably 5-15nm;

[0036] The specific surface area of ​​the filter element 6 is 100-1200 m². 2 / g, preferably 300-900m 2 / g.

[0037] The interior of the housing 1 is provided with a preservation solution for keeping the filter element 6 moist for a long time. The preservation solution is 0.9% sodium chloride injection or water for injection, preferably 0.9% sodium chloride injection. The preservation solution can keep the filter element 6 moist during storage, making it convenient to take out and use.

[0038] Finally, it should be noted that the above embodiments are only used to illustrate and not limit the technical solutions of the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the present invention without departing from the spirit and scope of the present invention. Any modifications or partial substitutions should be covered within the scope of the claims of the present invention.

Claims

1. An adsorption-type blood purifier, characterized in that, Includes a shell (1), which is a tube with both ends open, and both ends of the shell (1) are equipped with end caps (2). The end cap (2) at the upper end of the shell (1) is equipped with a bleeding port (3), and the end cap (2) at the lower end of the shell (1) is equipped with a blood inlet (4). Both the upper and lower ends of the side of the shell (1) are equipped with liquid outlets (5). The inside of the shell (1) is equipped with a filter element (6), which can adsorb medium and large molecular toxins in the blood and filter out excess water and small molecular toxins in the blood. The upper end of the housing (1) is equipped with a filter membrane (7) capable of secondary filtration. The filter membrane (7) can guide the filtered medium and large molecular toxins, allowing them to enter the interior of the filter frame (8). The filter membrane (7) is covered on the mounting frame (9). The mounting frame (9) is an arch shape with a low center and a high perimeter. The material of the mounting frame (9) can produce elastic deformation. The filter membrane (7) is interlocked with the filter frame (8) through the mounting frame (9) fixedly connected to it. The filter frame (8) includes a base ring (801), an inwardly tapered guide ring (802) is fixedly connected to the base ring (801), a support ring (803) is fixedly connected to the inner ring surface of the guide ring (802), and a filter ring (804) is covered on the support ring (803).

2. The adsorption-type blood purifier according to claim 1, characterized in that, The upper end of the support ring (803) is outwardly hooked.

3. The adsorption-type blood purifier according to claim 1, characterized in that, The filter element (6) is made of a porous water-insoluble polymer and has multiple through holes for blood cells to pass through.

4. The adsorption-type blood purifier according to claim 3, characterized in that, The filter element (6) has 5,000-25,000 central channels; The inner diameter of the central channel of the filter element (6) is 150-250um.

5. An adsorption-type blood purifier according to claim 4, characterized in that, The average pore size of the internal pore structure of the filter element (6) is 2-50 nm; The specific surface area of ​​the filter element (6) is 100-1200 m². 2 / g.

6. The adsorption-type blood purifier according to claim 1, characterized in that, The interior of the housing (1) is provided with a preservation solution for keeping the filter element (6) moist for a long time. The preservation solution is 0.9% sodium chloride injection or water for injection.

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