A composition, cosmetic and preparation method with dual effects of whitening and smoothing skin.

Abstract

This invention discloses a composition, cosmetic, and preparation method with dual whitening and skin-smoothing effects. The composition comprises acetyl glucosamine, ascorbic acid tetraisopalmitate, and adenosine compounds in a mass ratio of (0.1–5):(0.1–10):(0.01–7). It is applied in cosmetics. Compared with existing technologies, the components of this invention work synergistically, resulting in a mild and non-irritating composition with simple and clearly defined components, exhibiting excellent whitening and skin-smoothing functions.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, and in particular relates to a composition, cosmetic and preparation method with dual effects of whitening and smoothing the skin. Background Technology

[0002] Located on the body's surface, the skin is one of the most prominent organs in the aging process. The main characteristics of human aging include: thinning skin, wrinkles, decreased skin elasticity, pigmentation, muscle atrophy, and reduced skin's water retention capacity. Due to changes in modern lifestyles and the environment, such as frequent late nights, oily diets, excessive or incorrect skincare, and dusty environments, most people suffer from sub-optimal skin health. Their skin barrier is damaged, leading to dryness, redness, sensitivity, acne, and other skin problems. People's skin is becoming increasingly fragile; the skin barrier is weakening, cell aging is accelerating, causing pigmentation, increased wrinkles, and faster aging.

[0003] Anti-aging and skin whitening are currently popular pursuits. It is generally believed that the effects of anti-aging active ingredients include scavenging free radicals, increasing cell proliferation, and slowing down the degradation of the extracellular matrix. Simultaneously, anti-aging cosmetics need to select high-quality skin care agents to replenish the skin with sufficient nutrients for deep nourishment. Currently, there are four main mechanisms of action for whitening cosmetics: inhibiting melanin production, inhibiting melanin migration to keratinocytes, inhibiting melanin transfer and promoting melanin decomposition, and inhibiting melanin polymerization and breaking down melanin. However, most ingredients with whitening or anti-aging effects rarely also possess anti-allergic properties, which may lead to skin allergies.

[0004] Currently, anti-aging and whitening cosmetics often use exfoliating agents to accelerate the shedding of the stratum corneum, achieving the effect of smoothing the skin. However, this also thins the stratum corneum, causing irritation that the skin cannot tolerate. For example, patent CN201810511521.1 relates to the preparation of a composition with skin-smoothing effects, but its effect is singular and does not have a whitening effect; patent CN201811603394.4 relates to the preparation of whitening reagents, but its effect is singular and does not have a skin-smoothing effect; although the skin care oil involved in patent CN201610825212.2 has the dual effects of whitening and smoothing the skin, the composition of the active ingredients is complex, and there are many factors affecting the product's efficacy, making it difficult to control the production quality. Summary of the Invention

[0005] The purpose of this invention is to overcome the defects of the prior art and provide a composition, cosmetic and preparation method with dual effects of whitening and smoothing the skin. The composition of the active ingredients is mild and non-irritating, the types are simple and clear, and it has good whitening and smoothing functions.

[0006] The objective of this invention can be achieved through the following technical solutions:

[0007] A composition with dual effects of whitening and smoothing the skin, characterized in that it comprises acetyl glucosamine, ascorbate tetraisopalmitate, and adenosine compounds in a mass ratio of (0.1-5):(0.1-10):(0.01-7).

[0008] Furthermore, the adenosine compounds include one or more of adenosine, adenosine phosphate, adenosine triphosphate, disodium adenosine triphosphate, and cyclic adenosine phosphate, with adenosine being preferred.

[0009] Furthermore, the mass ratio of the acetylglucosamine, ascorbate tetraisopalmitate, and adenosine compounds is (0.5-1):(0.2-2):(0.2-2).

[0010] The present invention also provides a cosmetic product containing the composition and excipients having the dual effects of whitening and smoothing the skin, wherein the composition having the dual effects of whitening and smoothing the skin accounts for 0.21 to 22% of the total mass of the cosmetic product.

[0011] Furthermore, the excipients include phase A, phase B, phase C, and phase D.

[0012] Phase A includes:

[0013] Thickener 0.3–10 wt%,

[0014] Preservative 0.1-1 wt%,

[0015] Chelating agent 0.01–0.1 wt%,

[0016] Solvent balance;

[0017] Phase B includes:

[0018] 1-4 wt% kaolin

[0019] 1-3 wt% titanium dioxide;

[0020] Phase C includes:

[0021] Phytosterols 2-4 wt%,

[0022] squalane 1-5 wt%,

[0023] Tocopheryl acetate 2-5 wt%,

[0024] behenol 1-4 wt%,

[0025] Isonononyl isononanoate 0.5–6 wt%;

[0026] Phase D includes:

[0027] PEG-100 stearate 1-3 wt%,

[0028] Daily-use fragrance 0.01–0.5 wt%.

[0029] Further, the thickener includes one or more of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylate / C10-30 alkanol acrylate crosspolymer, and ammonium acryloyldimethyl taurate / VP copolymer. Preferably, the thickener includes sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, and hydroxyethyl cellulose in a mass ratio of (1-4):(3-5):(0.2-0.6).

[0030] Further, the preservative includes one or two of phenoxyethanol, pentylene glycol, benzoic acid, benzoate, and ethylhexylglycerin. Preferably, the preservative includes phenoxyethanol and pentylene glycol in a mass ratio of (0.2-0.6):(0.2-0.6).

[0031] Furthermore, the chelating agent includes EDTA-2NA.

[0032] The present invention also provides a method for preparing the cosmetic, comprising the following steps:

[0033] (1) Mix and disperse phase A completely to obtain a mixture;

[0034] (2) With the composition having dual effects of whitening and smoothing skin as phase E, add phases B, C and E to the mixture obtained in step 1), heat to 50-80°C, and homogenize for 3-5 minutes at 2000-5000 r / min to ensure complete dispersion.

[0035] (3) Add phase D to the mixture obtained in step 2), homogenize it for 2-6 minutes at 2000-5000 r / min to make it completely emulsified, and heat it to 50-80℃ to obtain a cosmetic product that improves skin luster.

[0036] The cosmetics include toners, serums, creams, or sheet masks.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] (1) The active ingredients of this invention include N-Acetyl Glucosamine, Tetrahexyldecyl Ascorbate, and adenosine compounds. N-Acetyl Glucosamine, Tetrahexyldecyl Ascorbate, and adenosine compounds are common active ingredients in whitening skincare products. Their combined use can achieve a synergistic whitening effect. Among them, N-Acetyl Glucosamine, as an amino sugar, has moisturizing properties and promotes the metabolism of the stratum corneum in the skin. It can accelerate the renewal of keratinocytes and the shedding of melanin, thereby brightening the skin tone, and also enhancing the penetration effect of other active ingredients. Tetrahexyldecyl Ascorbate is a fat-soluble derivative of vitamin C, with stability and good permeability. It can inhibit the activity of tyrosinase, thereby reducing the production of melanin. It can also promote the synthesis of collagen, improve skin texture and elasticity, and make the skin tone more even and bright. Adenosine compounds, derivatives of adenosine acid, possess anti-inflammatory and tissue-repairing properties. They can reduce skin inflammation, promote skin regeneration and repair, reduce pigmentation, and improve skin tone. The combined use of these three ingredients produces multiple effects: acetylglucosamine accelerates keratinocyte renewal and melanin shedding, brightening the complexion while enhancing the penetration of other ingredients; ascorbate tetraisopalmitate inhibits melanin production, improving skin tone; and adenosine compounds reduce inflammation and promote skin repair. Therefore, the synergistic application of these three ingredients can achieve more significant whitening and smoothing effects through multiple pathways.

[0039] (2) The composition mentioned in this invention has the dual effects of whitening and smoothing the skin. The composition contains a variety of ingredients with clearly defined effects, which can simultaneously achieve a variety of skin-nourishing and beautifying effects, including reducing skin melanin and improving skin smoothness.

[0040] (3) The composition consists of a simple variety of components with clearly defined effects, and the components are mild and non-irritating. The production process is simple, making it easy to control the quality and scale of production, thereby ensuring its whitening and skin-smoothing effects. In addition, the final product does not contain surfactants, alcohol, etc., and has minimal skin irritation. Detailed Implementation

[0041] The following examples further illustrate various embodiments within the scope of this invention. These examples are given for illustrative purposes only and are not intended to limit the invention, as many changes can be made to the invention without departing from its spirit and scope.

[0042] All raw materials used in this invention are commercially available products, such as:

[0043] Acetyl glucosamine, abbreviated as NAG, or N-acyl glucosamine, mostly occurs in nature as chitin. It is a glucose-like monosaccharide widely found in animals, plants, and the human body, containing a nitrogen atom in its structure. NAG has high stability and high water solubility, allowing for large-scale production with easy control over production scale and quality. NAG possesses a natural keratin-regulating mechanism and is gentler and less irritating than acidic ingredients. NAG can enhance the whitening effect of ascorbic acid tetraisopalmitate, achieving a synergistic effect. As an effective exfoliating ingredient, NAG promotes the metabolism of aged keratinocytes, exfoliates dead skin cells, accelerates the shedding of melanin deposited in keratinocytes, and brightens skin tone. NAG can also penetrate the skin, promoting hyaluronic acid production. Simultaneously, it improves skin appearance, promotes water-oil balance, reduces fine lines, and beautifies the skin, making it one of the effective ingredients for whitening and smoothing the skin.

[0044] Acetyl glucosamine can be obtained from shrimp shells. After removing proteins and minerals from the shrimp shells, acid hydrolysis or enzymatic hydrolysis is used to obtain a mixture containing acetyl glucosamine. Purification of the mixture yields high-purity acetyl glucosamine. The formulation uses 0.1%-5% of the product. Because the raw materials are readily available and the preparation method is well-defined, it is a commercially available product with low cost and easy quality control.

[0045]

[0046] NAG, or acetyl glucosamine, has the following structural formula:

[0047] Ascorbate tetraisopalmitate, also known as fat-soluble vitamin C, esterified C, tetrahexyldecyl ascorbate, or VCIP, can inhibit tyrosinase activity and melanin production, making it a highly effective skin brightening and anti-pigmentation agent. Ascorbate tetraisopalmitate also promotes collagen production and has antioxidant, UV protection, and anti-aging effects. Collagen is the most abundant protein in the extracellular matrix and is most closely related to beauty, skincare, and tissue regeneration. On one hand, collagen forms fibers, thus constituting the three-dimensional structure of the extracellular matrix, providing cells with a living space and supporting the physiological morphology of tissues. On the other hand, the three-dimensional structure it constructs can regulate cell adhesion, proliferation, and differentiation, as well as the immune response of immune cells, through biomechanical transduction, thereby regulating tissue regeneration.

[0048] Tetraisopalmitate ascorbate is mainly used in cosmetics for whitening, moisturizing, and anti-oxidation. With a risk factor of 1, it is considered relatively safe and can be used with confidence. It generally has no effect on pregnant women. Tetraisopalmitate ascorbate is non-comedogenic, gentle, and non-irritating, and can be used on sensitive skin. It is one of the main active ingredients for whitening and smoothing the skin.

[0049] Ascorbate tetraisopalmitate, as a vitamin C derivative, penetrates the skin and transforms into vitamin C, thus exerting its vitamin C effects (hence it is also known as a vitamin C inducer). It is a colorless to pale yellow liquid with good oil solubility, dissolving widely and rapidly in esters, vegetable oils, ethanol, and hydrocarbons (except polyols). Furthermore, ascorbate tetraisopalmitate is mild and non-irritating, suitable for sensitive skin, and is used in formulations at concentrations of 0.1%-10%.

[0050] Any one of adenosine, adenosine monophosphate, adenosine triphosphate, disodium adenosine triphosphate, and cyclic adenosine monophosphate can be used as one of the effective ingredients for skin whitening and smoothing effects in this application. Together with acetylglucosamine and ascorbate tetraisopalmitate, they form a complex composition with skin whitening and smoothing effects, increasing the selectivity of product manufacturing and facilitating production. The aforementioned adenosine compounds have skin-beautifying effects such as replenishing skin energy, significantly improving skin elasticity, promoting skin cell metabolism, preventing skin tissue sagging, reorganizing skin structure, and restoring skin elasticity by tightening and shrinking pores.

[0051] The three key components mentioned above are all commercially available products. Their synergistic effect can effectively control product quality and make it easy to control production scale, thereby ensuring their good whitening and skin-smoothing effects.

[0052] The following specific examples will provide further illustration:

[0053] Example 1

[0054] A composition with dual whitening and skin-smoothing effects, using high-purity water as a solvent, contains the following effective ingredients for whitening and smoothing the skin: acetylglucosamine 0.72% by total product mass, ascorbate tetraisopalmitate 0.5%, and adenosine triphosphate disodium 1.2%. These three effective ingredients, designated as phase E, are combined with phases A, B, C, and D from Table 1 to form a face cream using the following method:

[0055] (1) Wet and disperse phase A completely in deionized water to obtain a mixture;

[0056] (2) Add phase B, phase C and phase E to the mixture in step 1), heat to 60°C, and homogenize at 3000 r / min for 3-5 minutes to ensure complete dispersion;

[0057] (3) Add phase D to step 2), homogenize at 3000 r / min for 3 minutes to emulsify completely, heat to 60°C to obtain a face cream composition that improves skin radiance.

[0058] Example 2

[0059] A composition with dual whitening and skin-smoothing effects, using high-purity water as a solvent, contains the following effective ingredients for whitening and smoothing the skin: acetylglucosamine 0.72% by total product mass, ascorbic acid tetraisopalmitate 1.2%, and adenosine monophosphate 0.5%. These three effective ingredients, designated as phase E, are combined with phases A, B, C, and D from Table 1 to form a face cream using the following method:

[0060] (1) Wet and disperse phase A completely in deionized water to obtain a mixture;

[0061] (2) Add phase B, phase C and phase E to the mixture in step 1), heat to 60°C, and homogenize at 3000 r / min for 3-5 minutes to ensure complete dispersion;

[0062] (3) Add phase D to step 2), homogenize at 3000 r / min for 3 minutes to emulsify completely, heat to 60°C to obtain a face cream composition that improves skin radiance.

[0063] Example 3

[0064] A composite composition with dual whitening and skin-smoothing effects, using high-purity water as a solvent, contains the following effective ingredients for whitening and smoothing the skin: acetylglucosamine 1.2%, ascorbic acid tetraisopalmitate 1.2%, and adenosine 1.28% by weight of the product. These three effective ingredients, designated as phase E, are combined with phases A, B, C, and D from Table 1 to form a face cream using the following method.

[0065] The preparation method is as follows:

[0066] (1) Wet and disperse phase A completely in deionized water to obtain a mixture;

[0067] (2) Add phase B, phase C and phase E to the mixture in step 1), heat to 60°C, and homogenize at 3000 r / min for 3-5 minutes to ensure complete dispersion;

[0068] (3) Add phase D to step 2), homogenize at 3000 r / min for 3 minutes to emulsify completely, heat to 60°C to obtain a face cream composition that improves skin radiance.

[0069] According to the formula in Table 1, Comparative Examples 1, 2, 3, 4, 5, 6, and 7 were prepared by following the method steps of Example 3 to obtain the face cream compositions of Comparative Examples 1-7, except that the components A, B, C, D, and E contained were different.

[0070] The contents of phases A, B, C, D, and E are shown in the table below:

[0071] Table 1. Raw material composition ratios for Examples 1-3 and Comparative Examples 1-7 (unit: %)

[0072]

[0073] Effect verification test case

[0074] I. Security Testing

[0075] Test samples: Examples 1-3 and Comparative Examples 1-7

[0076] Test subjects: 33 participants

[0077] Testing method: Safety will be tested by a third-party testing agency. Select an area not exceeding 50mm². 2 A suitable patch applicator with a depth of approximately 1 mm was used. Using a closed patch test method, approximately 0.02-0.025 ml (g) of the test sample was added into the applicator. The applicator was applied to the flexor side of the subject's forearm. After 24 hours, the test sample was removed. Skin reactions were observed at 0.5 h, 24 h, and 48 h after removal, and the results were recorded according to the skin reaction grading standards in the "Cosmetic Safety Technical Regulations 2015".

[0078] Table 2 Results of patch test

[0079] Note: Skin reaction grading standards;

[0080] Grade 0: Negative reaction;

[0081] Grade 1: Suspicious reaction; only slight erythema;

[0082] Grade 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present;

[0083] Grade 3: Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, vesicles; the reaction may extend beyond the tested area;

[0084] Grade 4: Extremely strong reaction (confluent herpes simplex reaction); obvious erythema, severe infiltration, edema, confluent herpes simplex, reaction extending beyond the test area.

[0085] Table 2

[0086]

[0087]

[0088] The results showed that the products of Examples 1-3 and Comparative Examples 1-7 all scored 0 at 30 min, 24 h, and 48 h, and no adverse skin reactions were observed, indicating that the products involved in this invention are safe and non-irritating to the skin.

[0089] II. Human Efficacy Testing:

[0090] (1) Subjects: 370 healthy volunteers, all of whom were female and aged 20-55.

[0091] All 370 participants were healthy volunteers from Shanghai, with no history of skin diseases or other serious illnesses in the past three months, and none had taken any antibiotics or hormonal medications. Written informed consent forms were provided to all participants before the study began, and they signed them after thorough communication. This research protocol has been approved by the ethics committee, and the entire study was subject to strict supervision and guidance from the ethics committee. The privacy and data security of the participants were strictly guaranteed.

[0092] Environmental conditions: The experimental environment was set according to the experimental requirements (temperature 20-22℃, humidity 40-60%), and the subjects were allowed to adapt to the experimental environment for 15-30 minutes or more.

[0093] (2) Test instruments:

[0094] 1.Mexameter(Courage&Khazaka GmbH,MX18,Cologne,Germany)

[0095] 2.Color Meter(Cortex Technology,DSMII colormeter,Denmark)

[0096] 3. Vc20 (Courage & Khazaka GmbH) vc20plus, Cologne, Germany)

[0097] ①Mexameter Test Principle and Application: The measurement is based on the absorption principle. The special probe of the MX 18 emits light of three wavelengths, and the receiver measures the light reflected back from the skin. The positions of the transmitter and receiver ensure that only diffuse and scattered light are measured. Because the amount of emitted light is fixed, the amount of light absorbed by the skin can be calculated. A significant decrease in skin melanin content before and after product use indicates that the tested product has a whitening effect. The test indicator is called Mexameter Skin Melanin.

[0098] ②Color Meter Testing Principle and Application: Skin color, melanin (melanin deposition), and erythema are measured by a detection chip illuminated by two high-intensity white LEDs. CIEL*a*b* is an index for evaluating skin color codes at the CIELab color space level, used to assess skin color. Each measurement produces three values ​​(L*, a*, b*), where L* is the skin color brightness, and (a*, b*) are the vector positions of the colors. The test index is named Skin Color. A larger measured skin brightness (L*) value indicates brighter skin; a smaller measured skin color (a*) value indicates improved redness; and a smaller measured skin color (b*) value indicates improved yellowness.

[0099] ③VC20 Testing Principle and Application: A skin image CCD testing system with an ultraviolet light source inside a special probe is used to test the skin surface, thus obtaining an image of the skin's active state. This black-and-white video signal is input into the testing system's digitizer for processing, and then input into a computer. Analysis using the dedicated active skin surface evaluation software SELS yields four numerical parameters evaluating the active skin surface condition, including the skin smoothness SEsm value. This instrument can be used by dermatologists, cosmetic and pharmaceutical researchers to observe skin pathology and pigmentation, and to evaluate the efficacy of cosmetics and pharmaceuticals.

[0100] (3) Experimental Methods: A series of tests were conducted on volunteers using various instruments. First, the subjects who passed the selection / exclusion screening form arrived at the testing center to sign the informed consent form, wash their face, straighten their hair, and sit quietly for 30 minutes. During the sitting period, the selection / exclusion screening form, skin type form, and subjective questionnaire were completed. The skin melanin M value, skin brightness L* value, a* value, b* value, and skin smoothness SEsm value of each subject were tested before the trial and after 2, 4, and 8 weeks of the trial. After obtaining the corresponding data, the change rate based on the pre-trial period was obtained by analyzing and organizing the data.

[0101] (4) Data analysis: After calculating the average value of the data obtained from each test, this experiment compares the average value of the corresponding test values ​​measured before the trial of different embodiments or comparative proportions with the test samples to obtain the mean change rate of the relevant parameters. If the change rate maintains a certain increase or decrease over a long period of time, it has a certain degree of universality.

[0102] (5) Instrument data processing and analysis

[0103] 1) Analysis of changes in melanin M value in the subjects' skin over time

[0104] Using the Mexameter instrument, the amount of emitted light and absorbed light by the skin for each subject across various embodiments and comparative examples can be obtained. After digital processing, the skin melanin M value can be derived. The mean M value of each subject's skin in each group, measured before the trial product was used as the starting value. Other data were compiled from the experimental group data and are shown in Table 3.

[0105] Table 3. Reduction rate of mean melanin M in the skin

[0106]

[0107] Where W2, W4, and W8 refer to the rate of reduction in the mean melanin M value of the subjects' skin after 2, 4, and 8 weeks of use, respectively, compared to the mean melanin M value of the skin before use.

[0108] The result is calculated as "(mean skin pigmentation M after sample use - mean skin pigmentation M before sample use) / mean skin pigmentation M before sample use" and the result is positive.

[0109] As shown in Table 3, the face cream containing three active ingredients simultaneously exhibited a significantly higher rate of reduction in melanin (M) compared to those using only one or two active ingredients. In particular, after using the test product in Example 3, the subjects generally showed a reduction in melanin (M) values ​​compared to the other groups. The reduction rate was 1.5-4 times that of the comparative group containing only active ingredients 1-2, and even 22 times that of the comparative group 7, which contained no active ingredients. These results demonstrate that, under the test conditions, the test products of Examples 1-3 can significantly reduce melanin (M) values ​​and have a whitening effect.

[0110] 2) Analysis of changes in skin brightness L* value of subjects over time

[0111] The skin luminance L* value for each subject across various embodiments and comparative examples was obtained using the Color Meter instrument. The average skin luminance L* value measured before the trial product was used as the starting value. Other data were compiled from the experimental group data and are shown in Table 4. Table 4 shows that:

[0112] Table 4. Mean increase rate of skin brightness (L*)

[0113]

[0114] W2, W4, and W8 refer to the rate of increase in skin brightness L value of each subject's corresponding skin after 2, 4, and 8 weeks of trial use, respectively, compared to the skin brightness L value before use. That is, it is calculated by "(mean skin L value after sample use - mean skin L value before sample use) / mean skin L value before sample use".

[0115] As shown in Table 4, the increase in skin brightness (L*) value was higher when using one or two of the three active ingredients in the face cream compared to using only one or two. In particular, after using the test product in Example 3, the subjects generally showed a higher skin brightness (L*) value compared to the other groups. These results demonstrate that, under the test conditions, the test products of Examples 1-3 can significantly increase skin brightness (L*) value and have a whitening effect.

[0116] 3) Analysis of changes in the subject's skin color a* value over time

[0117] The mean skin color (a*) of each subject across all embodiments and comparative examples was obtained using the Color Meter instrument. Using the mean skin color (a*) data of each subject in each group measured before the trial product as the starting value, and other data compiled from the experimental group data, Table 5 is obtained. As can be seen from Table 5:

[0118] Table 5. Reduction rate of mean skin color (a*)

[0119]

[0120] W2, W4, and W8 refer to the rate of decrease in the mean skin color a* of each subject's corresponding skin after 2, 4, and 8 weeks of trial use, respectively, compared to the mean skin color a* before trial use. Specifically, it is calculated by taking a positive value after calculating "(mean skin a* after using the sample - mean skin a* before using the sample) / mean skin a* before using the sample".

[0121] As shown in Table 5, the reduction rate of skin color a* value was higher when using one or two of the three active ingredients in the face cream compared to using only one or two. In particular, after using the test product in Example 3, the subjects generally showed a reduction in skin color a* value compared to the other groups. These results demonstrate that, under the test conditions, the test products of Examples 1-3 can significantly reduce skin color a* value, indicating an improvement in skin redness and a whitening effect.

[0122] 4) Analysis of changes in subjects' skin color b* value over time

[0123] The mean skin color b* for each subject across all embodiments and comparative examples was obtained using the Color Meter instrument. Using the mean skin color b* measured before the trial product as the starting value, and other data compiled from the experimental group, Table 6 was obtained. As can be seen from Table 6:

[0124] Table 6. Increase rate of skin color b* mean value

[0125]

[0126] W2, W4, and W8 refer to the rate of increase in the skin color b* value of each subject's corresponding skin after 2, 4, and 8 weeks of trial use, respectively, compared to the skin color b* value before trial use. The increase is calculated as "(mean skin b* after sample use - mean skin b* before sample use) / mean skin b* before sample use".

[0127] As shown in Table 6, the increase in skin color b* value was higher when using one or two of the three active ingredients in the face cream compared to using only one or two. In particular, after using the test product in Example 3, the subjects generally showed a higher mean skin color b* value compared to the other groups. These results suggest that, under the test conditions, the test product in Example 3 can significantly increase the mean skin color b* value, indicating an improvement in yellowing skin and a whitening effect.

[0128] 5) Analysis of changes in the SEsm value of the subjects' skin smoothness over time

[0129] Using the Vc20 instrument, skin images of each subject were obtained across various embodiments and comparative examples. After digital processing, the skin smoothness (SEsm) values ​​were obtained. The mean SEsm values ​​of each subject's skin in each group, measured without any experimental material applied, were used as the starting values. Other data were compiled from the experimental group data and are shown in Table 7. Table 7 shows:

[0130] Table 7. Reduction rate of mean SEsm value for skin smoothness

[0131]

[0132] W2, W4, and W8 refer to the rate of decrease in the mean skin smoothness SEsm of each subject's skin after 2, 4, and 8 weeks of trial use, respectively, compared to the mean skin smoothness SEsm before trial use. The positive value is calculated as "(mean skin SEsm after sample use - mean skin SEsm before sample use) / mean skin SEsm before sample use".

[0133] As shown in Table 7, the increase in skin color b* value was higher when using one or two of the three active ingredients in the face cream compared to using only one or two. In particular, after using the test product in Example 3, the subjects generally showed a decrease in skin smoothness SEsm value compared to the other groups. These results demonstrate that, under the test conditions, the test products of Examples 1-3 can significantly reduce skin smoothness SEsm, achieving the effect of narrowing wrinkles and smoothing the skin.

[0134] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A cosmetic product, characterized by, The cosmetic contains a composition and excipients with dual whitening and skin-smoothing effects, wherein the composition with dual whitening and skin-smoothing effects accounts for 0.21-22% of the total mass of the cosmetic. The composition with dual whitening and skin-smoothing effects includes acetyl glucosamine, ascorbate tetraisopalmitate, and adenosine compounds in a mass ratio of (0.72~1.2):(0.5-1.2):(0.5~1.28). The excipients include phase A, phase B, phase C, and phase D. Phase A includes: Thickener 0.3~10wt%, Preservative 0.1~1wt%, Chelating agent 0.01~0.1wt%, Solvent balance; Phase B includes: 1-4 wt% kaolin 1-3 wt% titanium dioxide; Phase C includes: Phytosterols 2-4 wt%, squalane 1~5wt%, Tocopheryl acetate 2-5 wt%, behenol 1~4 wt%, Isonononyl isononanoate 0.5~6wt%; Phase D includes: PEG-100 stearate 1~3wt%, Daily-use fragrance 0.01~0.5wt%; The adenosine compounds are selected from one or more of adenosine, adenosine phosphate, and disodium adenosine triphosphate.

2. The cosmetic product according to claim 1, characterized in that, The thickeners include one or more of the following: sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylate / C10-30 alkanol acrylate crosspolymer, and ammonium acryloyldimethyl taurate / VP copolymer.

3. The cosmetic product according to claim 1, characterized in that, The preservatives include one or two of phenoxyethanol, pentylene glycol, benzoic acid, benzoate, and ethylhexylglycerin.

4. The cosmetic product according to claim 1, characterized in that, The chelating agent mentioned includes EDTA-2NA.

5. A method for producing the cosmetic according to any one of claims 1 to 4, characterized by, Includes the following steps: (1) Mix and disperse phase A completely to obtain a mixture; (2) Using the composition with the dual effects of whitening and smoothing the skin as phase E, add phase B, phase C and phase E to the mixture obtained in step 1), heat to 50~80℃, and homogenize for 3-5 minutes at 2000~5000 r / min to make it completely dispersed. (3) Add phase D to the mixture obtained in step 2), homogenize it for 2-6 minutes at 2000-5000 r / min to make it completely emulsified, and heat it to 50-80℃ to obtain a cosmetic product that improves skin luster.

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