Anti-fat and anti-corrosion technology and application during transportation of 5-aminolevulinic acid

Abstract

The present invention relates to the field of logistics protection technology, and in particular to a 5-aminolevulinic acid anti-grease and anti-corrosion technology and application during transportation, comprising the following steps: S1: wrapping 5-aminolevulinic acid powder in a biodegradable polymer; S2: uniformly dispersing microencapsulated 5-aminolevulinic acid particles in a special gel matrix; S3: adding a nano-scale antioxidant to the gel matrix; S4: then adding antibacterial nanoparticles; S5: drying the gel matrix into a solid form; S6: placing the dried solid 5-aminolevulinic acid in a light-proof container for packaging. The present invention, by combining the use of microencapsulation technology, nano-scale antioxidants and antibacterial nanoparticles, significantly improves the stability and safety of 5-aminolevulinic acid during transportation and storage, while optimizing its transportation and storage conditions, greatly enhancing its application value in multiple fields.

Description

Technical Field

[0001] The present invention relates to the technical field of logistics protection, and in particular to a process and application of anti-grease and anti-corrosion during the transportation of 5-aminolevulinic acid. Background Art

[0002] 5-Aminolevulinic acid (5-ALA) is a biological compound with important applications in multiple fields. It plays a key role in the pharmaceutical, agricultural, and food industries, especially as a precursor in drug synthesis and plant growth regulators. However, the chemical properties of 5-ALA make it particularly susceptible to environmental factors during transportation and storage, such as temperature changes, humidity, and light, which may cause it to decompose or become lipidated and corrupted.

[0003] Currently, there are significant limitations to the transportation and storage methods for 5-ALA on the market. On the one hand, traditional transportation methods such as refrigeration or the use of chemical stabilizers can slow the degradation of 5-ALA to a certain extent, but these methods often cannot fully protect its stability, especially during long-distance transportation or extreme environments. On the other hand, existing technologies have failed to effectively address the lipidation and corruption problems that 5-ALA may encounter during transportation. Therefore, a more effective method is urgently needed to ensure the stability and safety of 5-ALA during transportation and storage. Summary of the Invention

[0004] Based on the above objectives, the present invention provides a process and application for preventing grease formation and corrosion during the transportation of 5-aminolevulinic acid.

[0005] The anti-fatification and anti-corrosion process during the transportation of 5-aminolevulinic acid includes the following steps:

[0006] S1: Using microencapsulation technology, 5-aminolevulinic acid powder is encapsulated in a biodegradable polymer to form tiny particles;

[0007] S2: Evenly dispersing the microencapsulated 5-aminolevulinic acid particles in a specially prepared gel matrix;

[0008] S3: adding nano-sized antioxidants to the gel matrix;

[0009] S4: then add antimicrobial nanoparticles;

[0010] S5: using low-temperature vacuum drying technology to dry the gel matrix into a solid form;

[0011] S6: placing the dried solid 5-aminolevulinic acid in a light-proof container for packaging;

[0012] S7: Use rehydration equipment at the destination to quickly convert the dry solids back to the original gel state for final use and disposal.

[0013] Furthermore, the S1 specifically includes:

[0014] S11: selecting a specific polymer as a microencapsulation material and controlling the molecular weight of the polymer to be between 10,000 and 100,000 Daltons, wherein the specific polymer is polylactic acid or polycaprolactone;

[0015] S12: mixing 5-aminolevulinic acid powder and a selected polymer in a mass ratio of 1:3 to 1:5 to form a mixture;

[0016] S13: evaporating the mixture using a solvent evaporation method, wherein the volume ratio of the solvent to the material is 1:10 to 1:20, and the solvent is ethanol or acetone;

[0017] S14: placing the mixture after evaporation of the solvent in a high-speed centrifuge and centrifuging at a speed of 1000-5000 rpm for 15-30 minutes to form microencapsulated particles;

[0018] S15: Collect the microencapsulated particles and vacuum dry them under sterile conditions for 24-48 hours.

[0019] Furthermore, the S2 specifically includes:

[0020] S21: selecting a special gel matrix, wherein the gel matrix is ​​carrageenan or agar;

[0021] S22: heating the gel matrix to 50-60 degrees Celsius to make it semi-fluid, and then adding the microencapsulated 5-aminolevulinic acid particles to the preheated gel matrix at a ratio of 1:5 to 1:10;

[0022] S23: The mixture was stirred using a mechanical stirrer at a speed of 200-500 rpm for 10-20 minutes to ensure that the 5-aminolevulinic acid particles were evenly dispersed in the gel matrix.

[0023] Furthermore, the S3 specifically includes:

[0024] S31: The selected nano-scale antioxidant is nano-vitamin C or nano-vitamin E;

[0025] S32: mixing the selected nano-scale antioxidant powder with ethanol to form an antioxidant solution with a concentration of 0.1-1%;

[0026] S33: adding the antioxidant solution to the preheated gel matrix containing the microencapsulated 5-aminolevulinic acid particles at a rate of 0.5-1 ml per minute;

[0027] S34: After adding the antioxidant solution, continue stirring the mixture using a mechanical stirrer at a speed of 200-500 rpm for 10-15 minutes.

[0028] Furthermore, the S4 specifically includes:

[0029] S41: selecting silver nanoparticles or zinc oxide nanoparticles as antibacterial nanoparticles;

[0030] S42: adding the selected antibacterial nanoparticles into distilled water at a mass ratio of 0.01-0.1% to prepare an antibacterial nanosuspension;

[0031] S43: slowly adding the antibacterial nanosuspension to the gel matrix containing microencapsulated 5-aminolevulinic acid particles and nano-sized antioxidants at a rate of 0.5-1 ml per minute;

[0032] S44: After adding the antibacterial nanosuspension, continue stirring the mixture using a mechanical stirrer at a speed of 200-500 rpm for 10-15 minutes.

[0033] Furthermore, the S5 specifically includes:

[0034] S51: transferring the gel matrix containing microencapsulated 5-aminolevulinic acid particles, nano-sized antioxidants, and antibacterial nanoparticles into a low-temperature vacuum desiccator;

[0035] S52: Setting the temperature of the vacuum dryer to -20 to -10°C;

[0036] S53: adjusting the pressure of the vacuum desiccator to 50-100 mTorr;

[0037] S54: starting a vacuum drying process, with the duration controlled to be 12-24 hours, until the gel matrix is ​​completely dried and forms a solid.

[0038] Furthermore, the S6 specifically includes:

[0039] S61: Before transferring the dried solid 5-aminolevulinic acid to a packaging container, first fill the container with a protective gas, which is nitrogen or an inert gas;

[0040] S62: transferring the dried solid 5-aminolevulinic acid into a pre-prepared packaging container, and then sealing the packaging container;

[0041] S63: Inspect the sealed packaging container to ensure it is intact and the label information is accurate, including the batch number, production date and expiration date.

[0042] Furthermore, the S7 specifically includes:

[0043] S71: removing the dry solid 5-aminolevulinic acid from the sealed packaging container and placing it in a dedicated container of the dehydration equipment;

[0044] S72: Add distilled water to the dehydration equipment, the amount of water added being 3-5 times the mass of the dry solid;

[0045] S73: Set the water addition rate of the dehydration equipment to 1-2 ml per minute, and maintain the entire dehydration process for 30-60 minutes, until the dry solid absorbs water evenly and gradually returns to its original gel state.

[0046] The above-mentioned anti-lipidification and anti-corrosion technology during the transportation of 5-aminolevulinic acid is used in the pharmaceutical, food additive or cosmetic industries.

[0047] Beneficial effects of the present invention:

[0048] In the present invention, 5-ALA is effectively encapsulated in a biodegradable polymer by adopting microencapsulation technology, which not only protects it from environmental factors such as temperature, humidity and light, but also significantly extends its shelf life, which is crucial for ensuring that 5-ALA maintains its chemical and biological activity during transportation and storage.

[0049] The present invention effectively prevents the oxidation and microbial contamination of 5-ALA by adding nano-scale antioxidants and antibacterial nanoparticles into the gel matrix. This protection mechanism is particularly important for maintaining the safety of its application in the pharmaceutical, food additive and cosmetic industries.

[0050] The present invention optimizes the transportation and storage conditions of 5-ALA through low-temperature vacuum drying technology and special packaging. This not only makes the transportation process safer and more economical, but also provides a reliable solution for the long-term storage of 5-ALA. In particular, after arriving at the destination, the dehydration equipment is used to quickly restore the original state, which improves the convenience and practicality of 5-ALA. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0052] Figure 1 The figure is a schematic diagram of the anti-grease and anti-corrosion technology process during the transportation of 5-aminolevulinic acid according to an embodiment of the present invention. DETAILED DESCRIPTION

[0053] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to specific embodiments.

[0054] It should be noted that, unless otherwise defined, the technical or scientific terms used in the present invention should have the usual meanings understood by people with ordinary skills in the field to which the present invention belongs. The "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0055] Example 1

[0056] like Figure 1 As shown, the anti-fatification and anti-corrosion process during the transportation of 5-aminolevulinic acid includes the following steps:

[0057] S1: Using microencapsulation technology, 5-aminolevulinic acid powder is encapsulated in a biodegradable polymer to form tiny particles to improve its stability;

[0058] S2: Evenly dispersing the microencapsulated 5-aminolevulinic acid particles in a specially prepared gel matrix;

[0059] S3: Add nano-scale antioxidants to the gel matrix to enhance the antioxidant effect and improve penetration;

[0060] S4: Antimicrobial nanoparticles are then added to provide long-lasting and broad-spectrum antimicrobial protection;

[0061] S5: using low-temperature vacuum drying technology to dry the gel matrix into a solid form;

[0062] S6: placing the dried solid 5-aminolevulinic acid in a light-proof container for packaging to prevent decomposition of the 5-aminolevulinic acid and facilitate transportation and storage;

[0063] S7: Use rehydration equipment at the destination to quickly convert the dry solids back to the original gel state for final use and disposal.

[0064] S1 specifically includes:

[0065] S11: selecting a specific polymer as a microencapsulation material, and controlling the molecular weight of the polymer to be 50,000 Daltons, wherein the specific polymer is polylactic acid;

[0066] S12: mixing 5-aminolevulinic acid powder and a selected polymer at a mass ratio of 1:4 to form a mixture;

[0067] S13: evaporating the mixture using a solvent evaporation method, wherein the volume ratio of the solvent to the material is 1:15, and the solvent is acetone;

[0068] S14: placing the mixture after evaporation of the solvent in a high-speed centrifuge and centrifuging at a speed of 3000 rpm for 20 minutes to form microencapsulated particles;

[0069] S15: Collect the microencapsulated particles and vacuum dry them under sterile conditions for 36 hours to ensure that the particles are dry and free of solvent residue.

[0070] S2 specifically includes:

[0071] S21: Select a special gel matrix, the gel matrix is ​​carrageenan, to ensure it has good biocompatibility and transparency;

[0072] S22: heating the gel matrix to 55 degrees Celsius to make it semi-fluid, and then adding the microencapsulated 5-aminolevulinic acid particles to the preheated gel matrix at a ratio of 1:7;

[0073] S23: The mixture was stirred at 350 rpm using a mechanical stirrer for 15 minutes to ensure that the 5-aminolevulinic acid particles were evenly dispersed in the gel matrix.

[0074] S3 specifically includes:

[0075] S31: The selected nano-scale antioxidant is nano-vitamin C;

[0076] S32: mixing the selected nano-scale antioxidant powder with ethanol to form an antioxidant solution with a concentration of 0.5%;

[0077] S33: adding the antioxidant solution to the preheated gel matrix containing the microencapsulated 5-aminolevulinic acid particles at a rate of 0.75 ml per minute to avoid particle aggregation and matrix destruction;

[0078] S34: After adding the antioxidant solution, continue to stir the mixture at a speed of 350 rpm using a mechanical stirrer for 13 minutes to ensure that the antioxidant is evenly dispersed and fully reacts with the 5-aminolevulinic acid particles.

[0079] S4 specifically includes:

[0080] S41: Silver nanoparticles were selected as antibacterial nanoparticles to ensure that they had broad-spectrum antibacterial activity and good biocompatibility;

[0081] S42: adding the selected antibacterial nanoparticles into distilled water at a mass ratio of 0.05% to prepare an antibacterial nanosuspension;

[0082] S43: Slowly adding the antimicrobial nanosuspension to the gel matrix containing the microencapsulated 5-aminolevulinic acid particles and the nanoscale antioxidant at a rate of 0.75 ml per minute to maintain the stability of the gel matrix;

[0083] S44: After adding the antibacterial nanosuspension, the mixture was stirred at 350 rpm for 13 minutes using a mechanical stirrer to ensure that the antibacterial nanoparticles were evenly dispersed in the gel matrix.

[0084] S5 specifically includes:

[0085] S51: transferring the gel matrix containing microencapsulated 5-aminolevulinic acid particles, nano-sized antioxidants, and antibacterial nanoparticles into a low-temperature vacuum desiccator;

[0086] S52: Setting the temperature of the vacuum dryer to -15°C to protect the active ingredient from heat damage;

[0087] S53: adjusting the pressure of the vacuum desiccator to 75 mTorr to promote efficient evaporation of water;

[0088] S54: starting a vacuum drying process, with the duration controlled to be 18 hours, until the gel matrix is ​​completely dried and forms a solid.

[0089] S6 specifically includes:

[0090] S61: Before transferring the dried solid 5-aminolevulinic acid to a packaging container, the container is first filled with a protective gas, which is nitrogen, to remove oxygen from the container and reduce the risk of oxidation;

[0091] S62: Transferring the dried solid 5-aminolevulinic acid into a pre-prepared packaging container, and then sealing the packaging container using a dedicated sealing machine to ensure that the container is completely sealed to prevent any external contaminants from entering;

[0092] S63: Inspect the sealed packaging container to ensure it is intact and the label information is accurate, including the batch number, production date and expiration date.

[0093] S7 specifically includes:

[0094] S71: removing the dry solid 5-aminolevulinic acid from the sealed packaging container and placing it in a dedicated container of the dehydration equipment;

[0095] S72: Add distilled water to the dehydration equipment in an amount of 4 times the mass of dry solids;

[0096] S73: Set the water addition rate of the rehydration equipment to 1.5 ml per minute to ensure that the dry solid absorbs water slowly and avoids structural damage due to rapid water absorption. Maintain the entire rehydration process for 45 minutes until the dry solid absorbs water evenly and gradually returns to its original gel state.

[0097] The above-mentioned anti-lipidification and anti-corrosion technology during the transportation of 5-aminolevulinic acid is used in the pharmaceutical, food additive or cosmetic industries.

[0098] Example 2

[0099] Step 1: We first selected polycaprolactone as the microencapsulation material, controlling its molecular weight at 10,000 Daltons. 5-aminolevulinic acid powder and polylactic acid were mixed at a mass ratio of 1:3. Then, ethanol was used as the solvent at a volume ratio of 1:10. The mixture was then centrifuged at 1,000 rpm in a high-speed centrifuge for 15 minutes to form microencapsulated particles. Finally, these particles were vacuum-dried under sterile conditions for 24 hours.

[0100] Step 2: Agar was selected as the gel matrix and heated to 50 degrees Celsius until it was semi-fluid. Then, the microencapsulated 5-aminolevulinic acid particles were added to the preheated gel matrix at a ratio of 1:5. A mechanical stirrer was used to stir at 200 rpm for 10 minutes to ensure that the particles were evenly dispersed in the gel.

[0101] Step 3: Nano-tocopherol (NTE) was selected as the antioxidant, and its powder was mixed with ethanol to form a 0.1% solution. This solution was added to the gel matrix containing the microencapsulated particles at a rate of 0.5 ml per minute and stirred at 200 rpm for 10 minutes using a mechanical stirrer.

[0102] Step 4: Nano-zinc oxide was selected as the antibacterial nanoparticles and these nanoparticles were added to distilled water at a mass ratio of 0.01% to prepare an antibacterial nanosuspension. Then, this suspension was slowly added to the gel matrix at a rate of 0.5 ml per minute and stirred at 200 rpm for 10 minutes.

[0103] Step 5: Transfer the gel matrix containing the microencapsulated particles, nano-sized antioxidants, and antibacterial nanoparticles to a low-temperature vacuum desiccator. Set the temperature of the desiccator to -20°C and the pressure to 50 mTorr. Start the drying process and control the duration to 12 hours to ensure that the gel matrix is ​​completely dry and forms a solid.

[0104] Step 6: Before packaging, fill the container with a protective inert gas. Then, transfer the dried solid 5-aminolevulinic acid to a pre-prepared light-proof container and ensure that the container is sealed. After sealing, inspect the packaging container to ensure it is intact and verify the label information.

[0105] Step 7: Remove the dried solid 5-aminolevulinic acid from the sealed packaging container and place it in a dedicated container for the dehydration equipment. Then, add distilled water to the container. The amount of water added is set to 3 times the mass of the dry solid. The water addition rate of the dehydration equipment is set to 1 ml per minute, and the entire dehydration process is maintained for 30 minutes. During this process, the dry solid will evenly absorb water and gradually return to its original gel state, which is convenient for final use and disposal.

[0106] Example 3

[0107] Step 1: We first selected polylactic acid as the microencapsulation material, controlling its molecular weight at 100,000 Daltons. 5-aminolevulinic acid powder and polylactic acid were mixed at a mass ratio of 1:5. Then, acetone was used as a solvent and treated at a volume ratio of 1:20. The mixture was then centrifuged at 5000 rpm in a high-speed centrifuge for 30 minutes to form microencapsulated particles. Finally, these particles were vacuum-dried under sterile conditions for 48 hours.

[0108] Step 2: Carrageenan was selected as the gel matrix and heated to 60 degrees Celsius until it became semifluid. Then, the microencapsulated 5-aminolevulinic acid particles were added to the preheated gel matrix at a ratio of 1:10. The mixture was stirred at 500 rpm for 20 minutes using a mechanical stirrer to ensure that the particles were evenly dispersed in the gel.

[0109] Step 3: Nano-vitamin C was selected as the antioxidant, and its powder was mixed with ethanol to form a 1% solution. This solution was added to the gel matrix containing the microencapsulated particles at a rate of 1 ml per minute and continued to be stirred at a speed of 500 rpm for 15 minutes using a mechanical stirrer;

[0110] Step 4: Silver nanoparticles were selected as antibacterial nanoparticles and added to distilled water at a mass ratio of 0.1% to prepare an antibacterial nanosuspension. This suspension was then slowly added to the gel matrix at a rate of 1 ml per minute and stirred at 500 rpm for 15 minutes.

[0111] Step 5: Transfer the gel matrix containing the microencapsulated particles, nano-sized antioxidants, and antibacterial nanoparticles to a low-temperature vacuum desiccator. Set the temperature of the desiccator to -10°C and the pressure to 100 mTorr. Start the drying process and control the duration to 24 hours to ensure that the gel matrix is ​​completely dry and forms a solid.

[0112] Step 6: Before packaging, fill the container with protective nitrogen gas. Then, transfer the dried solid 5-aminolevulinic acid to a pre-prepared light-proof container and ensure that the container is sealed. After sealing, inspect the packaging container to ensure it is intact and verify the label information.

[0113] Step 7: Remove the dried solid 5-aminolevulinic acid from the sealed packaging container and place it in a dedicated container for the dehydration equipment. Then, add distilled water to the container. The amount of water added is set to 5 times the mass of the dry solid. The water addition rate of the dehydration equipment is set to 2 ml per minute, and the entire dehydration process is maintained for 60 minutes. During this process, the dry solid will evenly absorb water and gradually return to its original gel state, which is convenient for final use and disposal.

[0114] Table 1 Comparison of method efficiency of various embodiments

[0115]

[0116] As can be seen from Table 1, Example 1 performed best in all evaluated performance indicators, especially in terms of microencapsulation efficiency, antioxidant performance, antibacterial effect, solid stability after drying, and heavy hydration efficiency. Example 1 was superior to Example 2 and Example 3. This is because Example 1 was more precise and optimized in material selection (polylactic acid), process parameters (such as centrifugal speed and drying time), and technical processing.

[0117] Although the overall cost of Example 1 is slightly higher than that of the other two examples, its superior performance in key performance indicators makes it a more superior choice, especially in application scenarios with high requirements for microencapsulation efficiency, stability and antibacterial properties. Although Examples 2 and 3 are slightly inferior in some performance indicators, they are still higher-cost alternatives and are suitable for cost-sensitive application scenarios.

[0118] In summary, Example 1 can be considered as the optimal implementation scheme due to its excellent performance in multiple key performance parameters, although the cost is slightly higher.

[0119] The present invention is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A process for preventing grease formation and corrosion during the transportation of 5-aminolevulinic acid, characterized in that: The following steps are involved: S1: Using microencapsulation technology, 5-aminolevulinic acid powder is encapsulated in a biodegradable polymer to form tiny particles; S2: Evenly dispersing the microencapsulated 5-aminolevulinic acid particles in a specially prepared gel matrix; S3: adding nano-sized antioxidants to the gel matrix; S4: then add antimicrobial nanoparticles; S5: using low-temperature vacuum drying technology to dry the gel matrix into a solid form; S6: placing the dried solid 5-aminolevulinic acid in a light-proof container and sealing it; S7: Use rehydration equipment at the destination to quickly convert the dry solids back to the original gel state for final use and disposal; Wherein said S2 specifically includes: S21: selecting a special gel matrix, wherein the gel matrix is ​​carrageenan or agar; S22: heating the gel matrix to 50-60 degrees Celsius to make it semi-fluid, and then adding the microencapsulated 5-aminolevulinic acid particles to the preheated gel matrix at a ratio of 1:5 to 1:10; S23: The mixture was stirred using a mechanical stirrer at a speed of 200-500 rpm for 10-20 minutes to ensure that the 5-aminolevulinic acid particles were evenly dispersed in the gel matrix.

2. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 1, characterized in that: Said S1 specifically includes: S11: selecting a specific polymer as a microencapsulation material and controlling the molecular weight of the polymer to be between 10,000 and 100,000 Daltons, wherein the specific polymer is polylactic acid or polycaprolactone; S12: mixing 5-aminolevulinic acid powder and a selected polymer in a mass ratio of 1:3 to 1:5 to form a mixture; S13: evaporating the mixture using a solvent evaporation method, wherein the volume ratio of the solvent to the material is 1:10 to 1:20, and the solvent is ethanol or acetone; S14: placing the mixture after evaporation of the solvent in a high-speed centrifuge and centrifuging at a speed of 1000-5000 rpm for 15-30 minutes to form microencapsulated particles; S15: Collect the microencapsulated particles and vacuum dry them under sterile conditions for 24-48 hours.

3. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 2, characterized in that: The S3 specifically includes: S31: The selected nano-scale antioxidant is nano-vitamin C or nano-vitamin E; S32: mixing the selected nano-scale antioxidant powder with ethanol to form an antioxidant solution with a concentration of 0.1-1%; S33: adding the antioxidant solution to the preheated gel matrix containing the microencapsulated 5-aminolevulinic acid particles at a rate of 0.5-1 ml per minute; S34: After adding the antioxidant solution, continue stirring the mixture using a mechanical stirrer at a speed of 200-500 rpm for 10-15 minutes.

4. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 3, characterized in that: The S4 specifically includes: S41: selecting silver nanoparticles or zinc oxide nanoparticles as antibacterial nanoparticles; S42: adding the selected antibacterial nanoparticles into distilled water at a mass ratio of 0.01-0.1% to prepare an antibacterial nanosuspension; S43: Slowly adding the antibacterial nanosuspension to the gel matrix containing microencapsulated 5-aminolevulinic acid particles and nano-sized antioxidants at a rate of 0.5-1 ml per minute; S44: After adding the antibacterial nanosuspension, continue stirring the mixture using a mechanical stirrer at a speed of 200-500 rpm for 10-15 minutes.

5. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 4, characterized in that: The S5 specifically includes: S51: transferring the gel matrix containing microencapsulated 5-aminolevulinic acid particles, nano-sized antioxidants, and antibacterial nanoparticles into a low-temperature vacuum desiccator; S52: Setting the temperature of the vacuum dryer to -20 to -10°C; S53: adjusting the pressure of the vacuum desiccator to 50-100 mTorr; S54: starting a vacuum drying process, with the duration controlled to be 12-24 hours, until the gel matrix is ​​completely dried and forms a solid.

6. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 5, characterized in that: The S6 specifically includes: S61: Before transferring the dried solid 5-aminolevulinic acid to a packaging container, first fill the container with a protective gas, which is nitrogen or an inert gas; S62: transferring the dried solid 5-aminolevulinic acid into a pre-prepared packaging container, and then sealing the packaging container; S63: Inspect the sealed packaging container to ensure it is intact and the label information is accurate, including the batch number, production date and expiration date.

7. The anti-grease and anti-corrosion process during transportation of 5-aminolevulinic acid according to claim 5, characterized in that: The S7 specifically includes: S71: removing the dry solid 5-aminolevulinic acid from the sealed packaging container and placing it in a dedicated container of the dehydration equipment; S72: Add distilled water to the dehydration equipment, the amount of water added being 3-5 times the mass of the dry solid; S73: Set the water addition rate of the dehydration equipment to 1-2 ml per minute, and maintain the entire dehydration process for 30-60 minutes, until the dry solid absorbs water evenly and gradually returns to its original gel state.

8. Application of the anti-lipidification and anti-corrosion process of 5-aminolevulinic acid during transportation according to any one of claims 1 to 7 in the pharmaceutical, food additive or cosmetic industries.

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