A polyisoprenyl phenolic compound, and a preparation method and application thereof

Abstract

The application provides a polyisoprenyl phenolic compound and a preparation method and application thereof. The application takes dry fruit bodies of Leucangium carthusianum as raw materials, extracts the dry fruit bodies through ethanol, extracts a petroleum ether phase through petroleum ether, and then coarsely separates the petroleum ether phase through petroleum ether-ethyl acetate solutions with different proportions, and then elutes and separates the petroleum ether phase through dichloromethane-methanol with a specific proportion, so as to obtain a polyisoprenyl phenolic compound with a novel structure. The polyisoprenyl phenolic compound provided by the application has a significant in-vitro inhibitory activity on HepG2 cell proliferation, and the inhibitory activity on liver cancer cells is obviously better than that of cisplatin, and the polyisoprenyl phenolic compound can be used for preparing medicines for treating and preventing liver cancer. Meanwhile, the raw material of the compound is rich in source, low in price, and simple in preparation process, and is convenient for industrial application, so that the discovery of the compound is expected to provide a promising treatment scheme for liver cancer patients, and has great significance for breaking through a bottleneck in liver cancer treatment.

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