A separator for concentrating red blood cells

Abstract

This invention discloses a separator for concentrating red blood cells, relating to the field of medical device technology. It includes a shell, a top cover, a wear-resistant plate, an upper shell, and an inner shell. An umbrella-shaped top plate is located at the top of the inner cavity, and a hydrophilic microporous membrane is located at the bottom of the umbrella-shaped top plate, forming an adsorption chamber. A vertical straight tube is located at the top of the umbrella-shaped top plate, extending into the adsorption chamber. A secondary cover is located above the umbrella-shaped top plate within the inner cavity, and an integrated straight sleeve is located at the top of the secondary cover. The straight tube is located inside the straight sleeve, with their central axes coinciding. The length of the straight tube is greater than that of the straight sleeve. The top cover is fastened above a limiting plate, with a rubber component between them. A liquid tube is located at the top of the top cover, with an outlet at the middle and an inlet at the top. Both the straight tube and the straight sleeve extend into the liquid tube. This invention removes oxygen and carbon dioxide more thoroughly, avoiding blood deterioration caused by the aggregation of hemolysin, hemoglobin, and ATP.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a separator for concentrating red blood cells. Background Technology

[0002] Chinese patent CN211838513U discloses a separation device for obtaining red blood cells by removing white blood cells. It includes a base, hydraulic cylinders, a working cylinder, and an inner cylinder. Sleeves are provided on the left and right sides of the top of the base, and telescopic rods are provided on the top of each sleeve. A support plate is provided on the top of each telescopic rod. Multiple shock-absorbing springs are provided between the base and the support plate. Hydraulic cylinders are provided on the left and right sides of the bottom of the base. The working cylinder is located on the top of the support plate. Support blocks are provided on the top of the left and right side walls of the inner cavity of the working cylinder. A servo motor is located on the top left side of the working cylinder, and an active conical wheel is provided on the shaft of the servo motor. This device can dampen vibrations, preventing damage caused by excessive shaking during centrifugation, reducing noise generated during centrifugation, and facilitating height adjustment for use by personnel of different heights.

[0003] However, it still has many drawbacks: the separator is bulky and inconvenient to use; the separation of oxygen and carbon dioxide is incomplete; having only one outlet can easily lead to contamination of the separated liquid; and the blood cell preparations in existing blood cell preservation systems have short shelf lives and are prone to expiration, which can easily lead to waste of blood. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a separator for concentrating red blood cells. By using oxygen and carbon dioxide adsorption media to remove oxygen and carbon dioxide from the blood, the removal of oxygen and carbon dioxide is more thorough and complete, avoiding blood deterioration caused by the aggregation of hemolysin, hemoglobin, and ATP.

[0005] The technical solution adopted in this invention is as follows:

[0006] A separator for concentrating red blood cells includes a shell, a top cover, a wear-resistant plate, an upper shell, and an inner shell;

[0007] The inner shell is located inside the outer shell, and their central axes coincide; the upper shell is located on top of the inner shell and the outer shell, forming an inner cavity and an outer cavity; the bottom center of the outer shell is provided with a drain hole for draining liquid from the outer cavity;

[0008] An umbrella-shaped top plate is provided at the top of the inner cavity, and a hydrophilic microporous membrane is provided at the bottom of the umbrella-shaped top plate, forming an adsorption chamber. A vertical straight tube is provided at the top of the umbrella-shaped top plate, extending into the adsorption chamber. A secondary cover is provided above the umbrella-shaped top plate in the inner cavity, and a straight sleeve is integrated with the secondary cover at its top. The straight tube is located inside the straight sleeve, and the central axes of the two coincide. The length of the straight tube is greater than that of the straight sleeve.

[0009] The upper shell has a through hole in the center, and the straight sleeve is located in the through hole; the wear-resistant plate is constrained on the step on the upper surface of the upper shell; a limiting plate is fitted on the outside of the straight sleeve, and the bottom of the limiting plate is in contact with the wear-resistant plate;

[0010] The top cover is fastened above the limiting piece, and a rubber part is provided between the two; the top of the top cover is provided with a liquid pipe, the middle position of the liquid pipe is provided with a liquid outlet, and the top end is provided with a liquid inlet; the straight pipe and the straight sleeve both extend into the liquid pipe, wherein the straight pipe is connected to the liquid inlet, and the height of the straight sleeve is lower than the liquid outlet.

[0011] Furthermore, the outer cavity region is located between the inner shell and the outer shell, while the inner cavity region is located inside the inner shell.

[0012] Furthermore, the edge of the limiting piece is provided with a flange, which extends to the inner wall of the top cover to form a limiting position.

[0013] Furthermore, the rubber pad is in the form of a snap-on cap, and its upper surface is provided with an annular protrusion embedded between the inner wall of the liquid tube and the straight sleeve.

[0014] Furthermore, the bottom of the hydrophilic microporous membrane is provided with a small hole that extends into the inner cavity; the wall surface of the inner shell is provided with filter holes.

[0015] Furthermore, there is a gap between the umbrella-shaped top plate and the sub-cover, and the two are supported by protrusions provided on the upper surface of the umbrella-shaped top plate.

[0016] The main innovative features of this invention are as follows:

[0017] 1. The red blood cell separation device manufactured by this patent is smaller in size and more convenient to carry.

[0018] 2. Using oxygen and carbon dioxide absorption media can completely remove oxygen and carbon dioxide from the blood.

[0019] 3. This patent has two outlets, avoiding the pollution caused by having only one outlet.

[0020] 4. The blood processed by this patent has a longer shelf life, avoiding waste caused by a short shelf life. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a diagram showing the location of the inlet and outlet for red blood cell separation in an embodiment of the present invention.

[0023] Figure 2 This is a concentrated red blood cell separation device according to an embodiment of the present invention.

[0024] Figure 3 This is a cross-sectional view of the separation device.

[0025] Figure 4 This is the top cross-section of the separation device.

[0026] Figure 5 This is a partial structural schematic diagram of an embodiment of the present invention;

[0027] Figure 6 yes Figure 5 A partial structural diagram.

[0028] Figure 7 yes Figure 6 Most of the structural diagrams;

[0029] Figure 8 This is a schematic diagram of the sub-cap and straight sleeve according to an embodiment of the present invention.

[0030] In the diagram: 1. Liquid inlet, 2. Liquid pipe, 3. Secondary cover, 4. Rubber part, 5. Limiting plate, 6. Wear-resistant plate, 7. Upper shell, 8. Outer shell, 9. Hydrophilic microporous membrane, 10. Inner shell, 11. Umbrella-shaped top plate, 12. Secondary cover, 13. Straight sleeve, 14. Straight pipe.

[0031] Specific implementation measures

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] It should be noted that in the description of this invention, the terms "upper", "lower", "top", "bottom", "one side", "the other side", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention and simplifying the description, and do not mean that the device or element must have a specific orientation, or be constructed and operated in a specific orientation.

[0034] A separator for concentrating red blood cells includes a shell, a top cover, a wear-resistant plate, an upper shell, and an inner shell;

[0035] The inner shell is located inside the outer shell, and their central axes coincide; the upper shell is located on top of the inner shell and the outer shell, forming an inner cavity and an outer cavity; the bottom center of the outer shell is provided with a drain hole for draining liquid from the outer cavity;

[0036] An umbrella-shaped top plate is provided at the top of the inner cavity, and a hydrophilic microporous membrane is provided at the bottom of the umbrella-shaped top plate, forming an adsorption chamber. A vertical straight tube is provided at the top of the umbrella-shaped top plate, extending into the adsorption chamber. A secondary cover is provided above the umbrella-shaped top plate in the inner cavity, and a straight sleeve is integrated with the secondary cover at its top. The straight tube is located inside the straight sleeve, and the central axes of the two coincide. The length of the straight tube is greater than that of the straight sleeve.

[0037] The upper shell has a through hole in the center, and the straight sleeve is located in the through hole; the wear-resistant plate is constrained on the step on the upper surface of the upper shell; a limiting plate is fitted on the outside of the straight sleeve, and the bottom of the limiting plate is in contact with the wear-resistant plate;

[0038] The top cover is fastened above the limiting piece, and a rubber part is provided between the two; the top of the top cover is provided with a liquid pipe, the middle position of the liquid pipe is provided with a liquid outlet, and the top end is provided with a liquid inlet; the straight pipe and the straight sleeve both extend into the liquid pipe, wherein the straight pipe is connected to the liquid inlet, and the height of the straight sleeve is lower than the liquid outlet.

[0039] Furthermore, the outer cavity region is located between the inner shell and the outer shell, while the inner cavity region is located inside the inner shell.

[0040] Furthermore, the edge of the limiting piece is provided with a flange, which extends to the inner wall of the top cover to form a limiting position.

[0041] Furthermore, the rubber pad is in the form of a snap-on cap, and its upper surface is provided with an annular protrusion embedded between the inner wall of the liquid tube and the straight sleeve.

[0042] Furthermore, the bottom of the hydrophilic microporous membrane is provided with a small hole that extends into the inner cavity; the wall surface of the inner shell is provided with filter holes.

[0043] Furthermore, there is a gap between the umbrella-shaped top plate and the sub-cover, and the two are supported by protrusions provided on the upper surface of the umbrella-shaped top plate.

[0044] The following is a more specific embodiment:

[0045] Reference Figures 1 to 8 This embodiment comprises an inlet, an outlet, a discharge outlet, an inner shell (plasma filter) 10, a hydrophilic microporous membrane 9, an upper shell 7, and an outer shell 8. The hydrophilic microporous membrane 9 has numerous carbon dioxide / oxygen-consuming microspheres. Whole blood or whole blood donor blood containing an anticoagulant enters through the inlet. After passing through the device, a concentrated red blood cell concentrate with reduced white blood cells / oxygen / carbon dioxide levels flows out from the discharge outlet and is collected in a storage bag; plasma is filtered through a membrane (inner shell 10) capable of separating plasma from blood. After being collected in a plasma collection chamber between the inner and outer shells, the plasma leaves the device through the plasma outlet, which is depleted of white blood cells / oxygen / carbon dioxide levels.

[0046] A concentrated red blood cell separator includes: 1. Inlet; 2. Liquid path; 3. Secondary cover; 4. Rubber component; 5. Limiting plate; 6. Wear-resistant plate; 7. Upper shell; 8. Outer shell; 9. Hydrophilic microporous membrane; and 10. Plasma filter.

[0047] Working principle:

[0048] The main objective of this invention is to provide a device for extending the storage time of blood.

[0049] This invention was developed based on the fact that red blood cells are located on the outer side during centrifugation. Structurally, the rubber component 4 presses down on the limiting plate 5, which in turn presses down on the wear-resistant plate 6. Whole blood containing anticoagulant enters the inner chamber surrounded by the hydrophilic microporous membrane 9 through the inlet via a straight tube. Then, a cleaning solution for rinsing the blood is added to the inner chamber through the inlet. Simultaneously, an external linkage device presses down on the inlet, causing the rubber component 4 to shift. This step reduces friction during centrifugation, facilitating centrifugation of the plasma filter 10. After centrifugation, the cleaning solution and remaining blood components, as the sample volume and centrifugation speed increase, are located on the inner side and separated in the outlet distribution chamber between the hydrophilic microporous membrane and the inner shell due to negative pressure, exiting from the outlet.

[0050] Red blood cells are filtered through the dense pores (7-300 μm) of the hydrophilic microporous membrane 9 and the plasma filter 10, with the red blood cell component located on the outermost side and separated via the discharge port. This blood, which has been depleted by white blood cells, oxygen, and carbon dioxide, can be stored at low temperatures for extended periods.

[0051] To achieve the above objectives, the present invention provides a separation device that is small in size, lightweight, and easy to carry. It includes a white blood cell / oxygen / carbon dioxide consuming medium capable of consuming components in the blood, thus enabling more thorough separation of concentrated red blood cells.

[0052] The concentrated red blood cells and residual plasma prepared using this equipment are produced from two outlets, avoiding the risk of contamination.

[0053] The working principle of the outlet distribution chamber between the hydrophilic microporous membrane and the inner shell: It serves as an outlet for the cleaning fluid and residual blood components, providing a location for these components to be discharged from the outlet. When the external linkage device presses the inlet, a gap appears between the outlet distribution chamber and the upper shell, eliminating the friction between them and facilitating the discharge of the aforementioned components from the separator.

[0054] The working principle of the rubber component 4 is as follows: the rubber component 4 fills the gap between the liquid pipe wall and the straight sleeve to achieve a sealing effect. When the external equipment presses the liquid inlet, the rubber component 4 deforms, while still ensuring that the container remains in a sealed environment.

[0055] The working principle of the hydrophilic microporous membrane 9 is as follows: As a leukocyte / oxygen / carbon dioxide consumption medium, the hydrophilic microporous membrane is a multilayer membrane that allows plasma to flow into the outer lumen. It has CaO that can adsorb carbon dioxide. When CaO comes into contact with water, it reacts with carbon dioxide to form CaCO3. Leukocytes and oxygen consumption medium can bind to platelets and leukocytes in whole blood and consume oxygen from red blood cells.

[0056] The working principle of the plasma separator 10 is as follows: it can centrifuge around the liquid tube. Its working principle is to separate blood into plasma and blood cells through centrifugation. The plasma is located on the outside of the centrifuge and flows out through the liquid outlet.

Claims

1. A separator for concentrating red blood cells, comprising a housing, characterized in that, It also includes a top cover, wear-resistant sheet, upper shell, and inner shell; The inner shell is located inside the outer shell, and their central axes coincide; the upper shell is located on top of the inner shell and the outer shell, forming an inner cavity and an outer cavity; the bottom center of the outer shell is provided with a drain hole for draining liquid from the outer cavity; An umbrella-shaped top plate is provided at the top of the inner cavity, and a hydrophilic microporous membrane is provided at the bottom of the umbrella-shaped top plate, forming an adsorption chamber. A vertical straight tube is provided at the top of the umbrella-shaped top plate, extending into the adsorption chamber. A secondary cover is provided above the umbrella-shaped top plate in the inner cavity, and a straight sleeve is integrated with the secondary cover at its top. The straight tube is located inside the straight sleeve, and the central axes of the two coincide. The length of the straight tube is greater than that of the straight sleeve. The upper shell has a through hole in the center, and the straight sleeve is located in the through hole; the wear-resistant plate is constrained on the step on the upper surface of the upper shell; a limiting plate is fitted on the outside of the straight sleeve, and the bottom of the limiting plate is in contact with the wear-resistant plate; The top cover is fastened above the limiting piece, and a rubber part is provided between the two; the top of the top cover is provided with a liquid pipe, the middle position of the liquid pipe is provided with a liquid outlet, and the top end is provided with a liquid inlet; the straight pipe and the straight sleeve both extend into the liquid pipe, wherein the straight pipe is connected to the liquid inlet, and the height of the straight sleeve is lower than the liquid outlet.

2. A separator for concentrating red blood cells according to claim 1, characterized in that, The outer cavity region is located between the inner shell and the outer shell, while the inner cavity region is located inside the inner shell.

3. A separator for concentrating red blood cells according to claim 1, characterized in that, The edge of the limiting piece is provided with a flange, which extends to the inner wall of the top cover to form a limiting position.

4. A separator for concentrating red blood cells according to claim 1, characterized in that, The rubber component is a snap-on type, and its upper surface is provided with an annular protrusion embedded between the inner wall of the liquid tube and the straight sleeve.

5. A separator for concentrating red blood cells according to claim 1, characterized in that, The bottom of the hydrophilic microporous membrane has a small hole that extends into the inner cavity; the wall of the inner shell has filter holes.

6. A separator for concentrating red blood cells according to claim 1, characterized in that, There is a gap between the umbrella-shaped top plate and the sub-cover, and the two are supported by protrusions on the upper surface of the umbrella-shaped top plate.

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