Industrial continuous process for the preparation of a boswellia extract

CN117964677BActive Publication Date: 2026-08-28SHAANXI JIAHE PHYTOCHEM CO LTD
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Patent Information

Application Number
CN202410112614.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-01-26
Publication Date
2026-08-28
Estimated Expiration
2044-01-26

AI Technical Summary

Technical Problem

[0009]本发明的目的是解决现有乳香提取物的制备方法通常需要使用氢氧化钠或氢氧化钾等碱性溶剂,易使3-乙酰基-11-羰基-β-乳香酸(AKBA)产生降解,导致乳香提取物最佳活性成分流失,不利于工业化生产的技术问题,而提供一种乳香提取物的工业化连续制备方法

Benefits of technology

[0034]1.本发明一种乳香提取物的工业化连续制备方法,根据乳香酸、黄酮和多糖在不同溶剂及不同浓度中的溶解性差异,选择性地先采用60%-70%甲醇在40-50℃低温进行提取,可以将部分树脂酸及黄酮类成分提取出来,但是对乳香酸、多糖却有很好地保留,甲醇提取液浓缩后通过弱极性大孔树脂纯化即可得到乳香黄酮;甲醇提取残渣采用溶解性好的乙醇、丙醇或异丙醇提取,可以避免较多杂质的溶出,为后续分离纯化垫定了一个很好的基础。本发明在分离乳香酸的同时,也可以分离得到乳香黄酮和乳香多糖,实现了对乳香原料的综合利用,显著降低了单一成分的生产成本,更适合工业化生产。同时,本发明在乳香的纯化过程中避免使用碱性溶剂进行分离纯化,对3-乙酰基-11-羰基-β-乳香酸(AKBA)起到了很好的保护作用,操作简单,有效成分回收率高。

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Abstract

The present application relates to a kind of plant active ingredient extraction method, specifically to a kind of industrialized continuous preparation method of frankincense extract.The technical problem that the preparation method of existing frankincense extract is solved, using alkaline solvent, AKBA component is easily degraded, leading to the technical problem of the loss of the best active ingredient of frankincense extract.The method of the present application comprises the following steps: 1) the raw material of frankincense is extracted by methanol to obtain residue A and filtrate A;After the concentration of filtrate A, add anion polyacrylamide and filter, the filtrate is adsorbed and eluted by macroporous adsorption resin to obtain frankincense flavone;Residue A is extracted by alcohol organic solvent to obtain filtrate B and residue B;Residue B is extracted by water, concentrated, dried to obtain frankincense polysaccharide;2) filtrate B is first concentrated to alcohol degree 65%-75% and then adsorbed by adsorbent, and the supernatant is collected by filtration;The supernatant is concentrated to alcohol degree 10%-30%, and the first precipitate is obtained by filtration;3) add organic solvent C, stir and rinse, collect the second precipitate by filtration, and dry to obtain frankincense acid extract.
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Citation Information

Patent Citations

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