Plasmapheresis centrifuge potting process

Abstract

The present application belongs to the technical field of plasma separator, and particularly relates to a centrifugal glue filling process of a plasma separator. The process comprises the following steps: installing a sintered membrane into a shell of the plasma separator and sealing two ends of the membrane with glue injection covers to obtain a glue filling assembly; installing the glue filling assembly into a centrifugal bucket and setting a temperature of the centrifugal bucket; mixing A and B glues through a glue injector to obtain glue, and filling the glue into a glue distributor; setting a residence time of the glue in the glue distributor, a centrifugal rotating speed and a temperature of the centrifugal bucket, and distributing the glue in the glue distributor to two ends of the glue distributor under the action of centrifugal force; closing the centrifugal force after the glue is solidified under solidification conditions, taking out the plasma separator, and completing the glue filling; and controlling the residence time of the mixed A and B glues in the glue distributor to make the glue partially react and increase the viscosity, so that the glue is not easy to enter into the hollow fiber membrane of the plasma separator, and the problems of product hole blocking and hollow fiber membrane hole blocking caused by the centrifugal glue filling of the plasma separator are solved.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of plasma separators, and particularly relates to a centrifugal glue filling process of a plasma separator. BACKGROUND

[0002] Plasma separators are widely used in medical treatment, scientific research, pharmaceutical production and other fields. In medicine, plasma separators are mainly used for separating plasma so as to further extract and use plasma proteins to treat various diseases. In the field of scientific research, plasma separators can be used to prepare pure DNA, RNA and other substances and applied to the research of molecular biology. In the field of pharmaceutical production, plasma separators are used to prepare medicines and vaccines.

[0003] The production process of a hemodialysis device is roughly divided into the following processes: a membrane bundle extraction process, an infrared sintering process, a cover installation and glue injection process, a glue filling process, a head cutting process, an end cap screwing process, a wet method leak detection process, a microwave drying process and a tightness test process. Glue filling is a key process in the production of a hemodialysis device, that is, polyurethane glue is filled into a hemodialysis device semi-finished product to fill the space in the shell.

[0004] In the production process, glue is needed to fix the hollow fiber membrane in the shell, and the glue should not enter the hollow fiber membrane. The existing process is as follows: after A and B glue are mixed, the mixed A and B glue is centrifuged to the two ends of the product by centrifugal force, and then the glue is solidified. However, since the side wall hole of the plasma separation membrane product is large, the mixed A and B glue will enter the membrane according to the existing method, which will cause the product to be blocked. SUMMARY

[0005] The purpose of the present application is to provide a centrifugal glue filling process of a plasma separator, which controls the residence time of the mixed A and B glue in the glue separator, so that the glue is not easy to enter the hollow fiber membrane of the plasma separator, and solves the problem of product blocking.

[0006] In order to achieve the above object, the application adopts the following technical scheme: the centrifugal glue filling process of the plasma separator, comprising: installing the sintered membrane into the shell of the plasma separator and sealing the two ends with glue injection covers to obtain a glue filling assembly; installing the glue filling assembly into a centrifugal bucket and setting the temperature of the centrifugal bucket, then inserting and clamping the glue injection port of a glue separator into the shell of the plasma separator and into position; mixing A and B glue by a glue injector to obtain glue, and filling the glue into the glue separator; setting the residence time of the glue in the glue separator, the centrifugal speed and the temperature of the centrifugal bucket, and allowing the glue in the glue separator to be separated into two ends of the glue separator under the action of centrifugal force and flow into the plasma separator; continuing to centrifuge so that the glue is kept at the two ends of the plasma separator under the action of centrifugal force, and closing the centrifuge after the glue is solidified under solidification conditions, taking out the plasma separator, and completing the glue filling. Removing the glue injection cover, cutting the glue at the two ends of the plasma separator, and observing the hole blocking condition at the two ends of the plasma separator.

[0007] Preferably, the temperature of the centrifugal bucket is 55-65 DEG C.

[0008] Preferably, the A and B glue is two-component polyurethane glue.

[0009] Preferably, the glue filling temperature before filling the glue into the glue separator is 35-45 DEG C.

[0010] Preferably, the residence time of the glue is 55-65 S, the centrifugal speed of the centrifugal bucket is 400-500 rpm, and the temperature is 55-65 DEG C.

[0011] Preferably, the solidification condition is that the centrifuge is kept and the temperature is 55-65 DEG C for 15-20 min.

[0012] The technical effect and advantage of the application: compared with the prior art, the centrifugal glue filling process of the plasma separator has the following advantages:

[0013] The application installs the sintered membrane into the shell of the plasma separator and seals the two ends with glue injection covers to obtain a glue injection assembly; installs the glue injection assembly into a centrifugal barrel, sets the temperature of the centrifugal barrel, then inserts the glue injection port of a glue distributor into the filtrate port of the plasma separator and clamps in place; mixes A and B glue through a glue injector to obtain glue, and pours the glue into the glue distributor; sets the residence time of the glue in the glue distributor, the centrifugal speed and temperature of the centrifugal barrel, and the glue in the glue distributor is separated to the two ends of the glue distributor under the action of centrifugal force and flows into the plasma separator; continues to keep centrifugal to make the glue keep in the two ends of the plasma separator under the action of centrifugal force, and closes the centrifugal after the glue solidifies under the solidification condition, takes out the plasma separator, and completes the glue injection; controls the residence time of the mixed A and B glue in the glue distributor to make the glue partially react and increase the viscosity, so that the glue is not easy to enter the hollow fiber membrane of the plasma separator, solves the problem of hole blocking of the hollow fiber membrane caused by the centrifugal glue injection of the plasma separator, reduces the cost, and increases the production efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 The flow chart of the centrifugal glue injection process of the plasma separator. DETAILED DESCRIPTION

[0015] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments of the application. The specific embodiments described herein are only used to explain the application, and are not used to limit the application. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor are within the protection scope of the application.

[0016] Embodiment 1

[0017] The centrifugal glue injection process of the plasma separator provided in the embodiments of the application is shown in Figure 1 and includes the following steps.

[0018] Install the sintered membrane into the shell of the plasma separator and seal the two ends with glue injection covers to obtain a glue injection assembly.

[0019] Install the glue injection assembly into a centrifugal barrel, set the temperature of the centrifugal barrel, then insert the glue injection port of a glue distributor into the filtrate port of the plasma separator and clamp in place; the temperature of the centrifugal barrel is 55-65℃.

[0020] Mix A and B glue through a glue injector to obtain glue, and pour the glue into the glue distributor; A and B glue are two-component polyurethane glue, and the temperature before glue injection is 35-45℃.

[0021] The residence time of the glue in the glue distributor, the centrifugal speed of the centrifugal barrel and the temperature are set, the glue in the glue distributor is separated to both ends of the glue distributor under the action of centrifugal force and flows into the plasma separator; the residence time of the glue is 55-65S; the centrifugal speed of the centrifugal barrel is 400-500 rpm, and the temperature is 55-65℃.

[0022] The centrifugation is continued, so that the glue is kept at both ends of the plasma separator under the action of centrifugal force, and the glue is solidified under the solidification condition, then the centrifugation is stopped, the plasma separator is taken out, and the glue filling is completed; the solidification condition is that the centrifugation is kept and the temperature is 55-65℃ for 15-25 min.

[0023] The glue injection cover is removed, the glue cutting at both ends of the plasma separator is performed, and the hole blocking condition at both ends of the plasma separator is observed; a magnifying glass can be used to observe the hole blocking condition at both ends of the plasma separator.

[0024] Example 2

[0025] On the basis of Example 1, the residence time of the glue in the glue distributor is adjusted to 130S, the centrifugal speed is 850 rpm, and the temperature of the centrifugal barrel is adjusted.

[0026] Example 3

[0027] On the basis of Example 1, the residence time of the glue in the glue distributor is adjusted to 85S, the centrifugal speed is 600 rpm, and the temperature of the centrifugal barrel is adjusted.

[0028] Comparative Example 1

[0029] On the basis of Example 1, compared with Comparative Example 1, the residence time of the glue in the glue distributor is adjusted from 60S to 70S. The centrifugal speed and the temperature of the centrifugal barrel are adjusted. The hole blocking condition is observed.

[0030] Comparative Example 2

[0031] On the basis of Example 1, compared with Comparative Example 1, the residence time of the glue in the glue distributor is adjusted from 60S to 50S. The centrifugal speed and the temperature of the centrifugal barrel are adjusted. The hole blocking condition is observed.

[0032] Comparative Example 3

[0033] On the basis of Example 1, compared with Comparative Example 2, the residence time of the glue in the glue distributor is adjusted from 130S to 150S. The centrifugal speed and the temperature of the centrifugal barrel are adjusted. The hole blocking condition is observed.

[0034] Comparative Example 4

[0035] On the basis of example 1, on the contrary, the residence time of the glue in the glue distributor is changed from 130 to 110 S. The centrifugal speed and the temperature of the centrifugal barrel are the same. Observe the hole blocking situation.

[0036] Comparative example 5

[0037] On the basis of example 1, on the contrary, the residence time of the glue in the glue distributor is changed from 85 to 65 S. The centrifugal speed and the temperature of the centrifugal barrel are the same. Observe the hole blocking situation.

[0038] Comparative example 6

[0039] On the basis of example 1, on the contrary, the residence time of the glue in the glue distributor is changed from 85 to 100 S. The centrifugal speed and the temperature of the centrifugal barrel are the same. Observe the hole blocking situation.

[0040] Through the performance test of the above examples 1, 2, 3 comparison and examples 1, 4, 5 comparison, the test index is the qualified rate,

[0041] The test method is:

[0042] 1. Visual inspection: confirm whether the glue at both ends of the plasma separator is flat, without air bubbles, without perforation.

[0043] 2. Magnifying glass inspection: after cutting the glue, the end face is placed under the magnifying glass, and whether the end face is blocked (the number of holes blocked at both ends is greater than 10) and the glue is observed.

[0044] 3. Wet detection: if there are a large number of continuous bubbles in the plasma separator filter chamber during detection, the product is unqualified, and if there are no bubbles, it is qualified. The detection results are shown in table 1:

[0045] Pass rate Number of tests Number of passes Example 1 99.3％ 150 149 Example 2 33.3％ 150 50 Example 3 92％ 150 138 Comparative Example 1 46.6％ 80 37 Comparative Example 2 54％ 50 27 Comparative Example 3 0 20 0 Comparative Example 4 40％ 20 8 Comparative Example 5 55％ 20 11 Comparative Example 6 50％ 20 10

[0046] As can be seen from the above, under the conditions that the residence time of the glue is 55-65 S, the centrifugal speed of the centrifugal barrel is 400-500 rpm, and the temperature is 55-65 ℃, the qualified rate of glue filling is 99.3%, which is the optimal glue filling condition.

[0047] In the present application, by setting the residence time of the glue in the glue distributor to 55-65 S, the centrifugal speed of the centrifugal barrel to 400-500 rpm, and the temperature to 55-65 ℃, the glue in the glue distributor is separated to both ends of the glue distributor under the action of centrifugal force and flows into the plasma separator; part of the glue reacts to increase the viscosity, so that the glue is not easy to enter the hollow fiber membrane in the plasma separator, solving the problem of product hole blocking, solving the problem of hole blocking of hollow fiber membrane caused by centrifugal glue filling of plasma separator, reducing cost and increasing production efficiency.

[0048] Finally, it should be noted that the above only describes the preferred embodiments of the present application and is not intended to limit the present application. Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art will appreciate that the technical solutions described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalent features, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A process for centrifugal potting of a plasma separator, characterized in that The application relates to a method for filling a plasma separator with glue. The sintered membrane is installed in the shell of the plasma separator and the two ends are sealed with glue injection covers to obtain a glue injection assembly; The glue injection assembly is installed in a centrifugal barrel, the temperature of the centrifugal barrel is set, and then the glue injection port of a glue distributor is inserted into and clamped to the filter liquid port of the shell of the plasma separator; A and B glue are mixed by a glue injector to obtain glue water, and the glue water is injected into the glue distributor; The residence time of the glue water in the glue distributor, the centrifugal rotating speed and the temperature of the centrifugal barrel are set, the glue water in the glue distributor is separated to the two ends of the glue distributor under the action of centrifugal force and flows into the plasma separator; The centrifugal force is continuously kept to make the glue water keep in the two ends of the plasma separator under the action of the centrifugal force, the glue water is solidified under solidification conditions, the centrifugal force is turned off, the plasma separator is taken out, and the glue injection is completed; The residence time of the glue water is 55-65s; the centrifugal rotating speed of the centrifugal barrel is 400-500rpm, and the temperature is 55-65 DEG C.

2. The plasma separator centrifuge potting process of claim 1, wherein, The application further relates to: The glue injection covers are removed, the glue at the two ends of the plasma separator is cut, and the hole blocking conditions at the two ends of the plasma separator are observed.

3. The plasma separator centrifuge potting process of claim 1, wherein, The A and B glue are two-component polyurethane glue.

4. The plasma separator centrifuge potting process of claim 1, wherein, The glue water is injected into the glue distributor at a temperature of 35-45 DEG C.

5. The plasma separator centrifuge potting process of claim 1 wherein, The solidification conditions are that the centrifugal force is kept and the temperature is 55-65 DEG C for 15-25min.

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