Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, and preparation method and application thereof

Abstract

The application discloses a kind of Fe3O4@SiO2@PDA-PVP magnetic nano adsorption material and preparation method and application thereof, and magnetic nano adsorption material includes silica coated Fe3O4 Nanoparticle, polydopamine and polyvinylpyrrolidone, in preparation process, Fe3O4 Nanoparticle is synthesized using solvothermal method first, then Fe3O4 Nanoparticle is dispersed into ethanol aqueous solution and tetraethyl orthosilicate and ammonia are added, Fe3O4@SiO2 Microsphere is obtained by reaction, then Fe3O4@SiO2 Microsphere is dispersed in buffer solution, then hydrochloric acid dopamine is added, Fe3O4@SiO2@PDA Nanoparticle is obtained after reaction, finally Fe3O4@SiO2@PDA Nanoparticle is dispersed in polyvinylpyrrolidone aqueous solution to obtain Fe3O4@SiO2@PDA-PVP.The application uses the above-mentioned Fe3O4@SiO2@PDA-PVP magnetic nano adsorption material and preparation method and application thereof, using matrix solid phase dispersion method, through the way of grinding of magnetic nano adsorption material and traditional Chinese medicine material, polyphenol extraction is carried out, the use amount of organic solvent is greatly reduced, environmental protection is good, can improve the extraction of polyphenol of traditional Chinese medicine material, and the extracted polyphenol also has higher efficacy.

Description

Technical Field

[0001] This invention relates to the field of adsorption materials technology, and in particular to a Fe3O4@SiO2@PDA-PVP magnetic nano-adsorption material, its preparation method, and its application. Background Technology

[0002] Polyphenols are a class of compounds with multiple phenolic structures, mainly found in natural foods such as fruits, vegetables, tea, and traditional Chinese medicine materials. Polyphenols have advantages such as antioxidant capacity, anti-inflammatory effects, anti-tumor effects, and anti-aging effects. Currently, the extraction process of polyphenols from traditional Chinese medicine materials is mainly the traditional ultrasonic extraction method, which involves mixing the traditional Chinese medicine materials with an organic solvent and then subjecting them to ultrasound. However, the above method has many drawbacks: (1) large amounts of organic solvent are used, the recovery rate is low, and environmental pollution is significant; (2) the amount of polyphenols extracted is relatively small, resulting in waste of raw materials; (3) the efficacy of the extracted polyphenols is low. Summary of the Invention

[0003] The purpose of this invention is to provide a Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, its preparation method, and its application, in order to solve the problems of large organic solvent consumption, low polyphenol extraction yield, and low polyphenol efficacy in the above-mentioned ultrasonic extraction method for extracting polyphenols from traditional Chinese medicine materials.

[0004] To achieve the above objectives, the first aspect of the present invention provides a Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, wherein the magnetic nano-adsorbent material comprises Fe3O4 nanoparticles coated with silica, polydopamine, and polyvinylpyrrolidone.

[0005] A second aspect of this invention provides a method for preparing Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent materials, comprising the following steps: (1) Preparation of Fe3O4 nanoparticles Fe3O4 nanoparticles were synthesized using a solvothermal method. (2) Preparation of Fe3O4@SiO2 microspheres Fe3O4 nanoparticles were dispersed in an aqueous ethanol solution to form a suspension. Then, tetraethyl silicate and ammonia were added to the suspension. After the reaction was completed, the mixture was washed and dried to obtain silica-coated Fe3O4 nanoparticles, namely Fe3O4@SiO2 microspheres. (3) Preparation of Fe3O4@SiO2@PDA nanoparticles Fe3O4@SiO2 microspheres were dispersed in a buffer solution, and then dopamine hydrochloride was added. After the reaction was completed, Fe3O4@SiO2@PDA nanoparticles were obtained by magnetic separation, washing, and drying. (4) Preparation of magnetic nano-adsorption materials Fe3O4@SiO2@PDA nanoparticles were dispersed in an aqueous solution of polyvinylpyrrolidone, and then subjected to ultrasonication, washing, and drying to obtain Fe3O4@SiO2@PDA-PVP, which is a magnetic nano-adsorbent material.

[0006] Preferably, the specific preparation process of Fe3O4 nanoparticles in step (1) is as follows: Ferric chloride and sodium acetate were dissolved in ethylene glycol and dispersed by stirring and ultrasonication until a brownish-yellow solution was formed. The brownish-yellow solution was then transferred to an autoclave for a solvothermal reaction. After the reaction was completed, Fe3O4 nanoparticles were obtained by magnetic separation, washing and drying.

[0007] Preferably, the molar ratio of ferric chloride and sodium acetate in step (1) is 1:5 to 10.

[0008] Preferably, the molar ratio of ferric chloride and sodium acetate in step (1) is 1:8.8.

[0009] Preferably, the temperature of the solvothermal method in step (1) is 180-220°C and the time is 5-10h.

[0010] Preferably, the temperature of the solvothermal method in step (1) is 200°C and the time is 6 hours.

[0011] Preferably, in step (2), the ratio of Fe3O4 nanoparticles, tetraethyl silicate and ammonia is 0.1-0.5g: 1-5mL: 1-5mL.

[0012] Preferably, the ratio of Fe3O4 nanoparticles, tetraethyl silicate and ammonia in step (2) is 0.2g:2mL:3mL.

[0013] Preferably, the volume ratio of ethanol to water in the ethanol-water solution in step (2) is 4:1.

[0014] Preferably, in step (3), the ratio of Fe3O4@SiO2 microspheres to dopamine hydrochloride is 1-5g: 1-5g.

[0015] Preferably, in step (3), the ratio of Fe3O4@SiO2 microspheres to dopamine hydrochloride is 1.0g:1.0g.

[0016] Preferably, in step (4), the mass ratio of Fe3O4@SiO2@PDA nanoparticles to polyvinylpyrrolidone is 0.1-1.0:1-5.

[0017] Preferably, in step (4), the mass ratio of Fe3O4@SiO2@PDA nanoparticles to polyvinylpyrrolidone is 0.5:2.

[0018] Preferably, the drying temperature in steps (1)-(4) is 50°C, the drying time is 12h, and the product is washed with ethanol and deionized water.

[0019] The third aspect of this invention provides an application of Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, specifically its application in the extraction of polyphenols from traditional Chinese medicine materials.

[0020] The preferred method for polyphenol extraction from traditional Chinese medicine materials is as follows: The traditional Chinese medicine materials and magnetic nano-adsorbent materials are mixed and ground to obtain a mixture. The mixture is then transferred to an ethanol-water solution for ultrasonic elution. After elution, the magnetic nano-adsorbent materials are separated by magnetic separation, and the remaining traditional Chinese medicine materials are removed by filtration to obtain a polyphenol solution.

[0021] Preferably, the medicinal materials include one of the following: pomegranate seeds, Dendrobium officinale, and grape seeds.

[0022] Preferred Chinese medicinal materials include one of the following: ginseng, dendrobium, ganoderma, cordyceps, white truffle, black truffle, cistanche, rhodiola, astragalus, camellia, milk thistle, and saffron.

[0023] Preferably, the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material yields a polyphenol extraction content of 80-90 mg / g from pomegranate seeds.

[0024] Preferably, the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material exhibits a DPPH free radical scavenging rate of >85% for polyphenols extracted from pomegranate seeds.

[0025] Preferably, the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material exhibits a DPPH free radical scavenging rate >80% for polyphenols extracted from Dendrobium officinale.

[0026] Preferably, the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material exhibits a DPPH free radical scavenging rate of >90% for grape seed polyphenols.

[0027] Therefore, the present invention, employing the above-described Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, its preparation method, and its application, has the following beneficial effects: (1) The present invention uses a matrix solid-phase dispersion method to extract polyphenols by grinding Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent materials and traditional Chinese medicine materials, which greatly reduces the amount of organic solvents used and is more environmentally friendly.

[0028] (2) The matrix solid phase dispersion method of the present invention can improve the extraction of polyphenols from traditional Chinese medicine materials, and the extracted polyphenols also have high efficacy.

[0029] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0030] Figure 1 These are SEM images of Example 1 ((a) Fe3O4, (b) Fe3O4@SiO2, (c) Fe3O4@SiO2@PDA, (d) Fe3O4@SiO2@PDA-PVP); Figure 2 This is the infrared spectrum of Example 1; Figure 3 This is a comparison chart of the content of grape seed polyphenols extracted using different extraction methods; Figure 4 This is a comparison chart of the polyphenol content extracted from pomegranate seeds using different adsorption materials. Detailed Implementation

[0031] The present invention will be further described below. It should be noted that this embodiment is based on the present technical solution and provides detailed implementation methods and specific operation processes, but the present invention is not limited to this embodiment.

[0032] Example 1 A method for preparing Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material includes the following steps: (1) Preparation of Fe3O4 nanoparticles 2.7 g FeCl3·6H2O and 7.2 g anhydrous sodium acetate were dissolved in 50 mL ethylene glycol and stirred and ultrasonically dispersed at room temperature for 10 min until all the solids were dissolved to form a brownish-yellow solution. The uniform brownish-yellow solution was then transferred to a stainless steel autoclave lined with polytetrafluoroethylene and heated at 200 °C for 6 h. After the reaction was completed, Fe3O4 nanoparticles were separated by magnetic separation, washed several times with ethanol and deionized water, and vacuum dried at 50 °C for 12 h.

[0033] (2) Preparation of Fe3O4@SiO2 microspheres 0.2 g of the prepared Fe3O4 nanoparticles were dispersed in 150 mL of an ethanol-water solution to form a suspension. The volume ratio of ethanol to water in the ethanol-water solution was 4:1. The suspension was sonicated until completely dispersed, and no solid precipitate was observed. Then, 2 mL of tetraethyl orthosilicate (TEOS) and 3 mL of ammonia water were slowly added dropwise to the flask, and the mixture was reacted with mechanical stirring at room temperature for 8 h. Finally, the Fe3O4 particles coated with silica were thoroughly washed with ethanol and deionized water and dried in a vacuum oven at 50 °C for 12 h to obtain Fe3O4@SiO2 microspheres.

[0034] (3) Preparation of Fe3O4@SiO2@PDA nanoparticles 1.00 g of Fe3O4@SiO2 microsphere nanoparticles were ultrasonically dispersed in 500 mL of HCl-Tris buffer (10 mM, pH 8.5), followed by the addition of 1.00 g of dopamine hydrochloride. The mixture was mechanically stirred at room temperature for 24 h. After the reaction was complete, the Fe3O4@SiO2@PDA nanoparticles were separated using a magnet, washed with deionized water and anhydrous ethanol, and dried at 50 °C for 12 h to obtain Fe3O4@SiO2@PDA.

[0035] (4) Preparation of Fe3O4@SiO2@PDA-PVP 0.50 g of Fe3O4@SiO2@PDA was ultrasonically dispersed in 500 ml of a 4.0 mg / ml polyvinylpyrrolidone (PVP) aqueous solution. The mixture was ultrasonicated for 1 h and then stirred at 30 °C for 24 h. The poorly adsorbed PVP was removed by washing with deionized water several times. The mixture was then dried in a vacuum oven at 50 °C for 12 h to obtain Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material.

[0036] Example 2 The Fe3O4@SiO2@PDA-PVP magnetic nanomaterials prepared in Example 1 were mixed and ground with traditional Chinese medicine materials using a matrix solid-phase dispersion method to extract polyphenols. The traditional Chinese medicine materials were one of grape seeds, pomegranate seeds, and Dendrobium officinale.

[0037] The specific process is as follows: Grape seeds, pomegranate seeds, and Dendrobium officinale medicinal materials were pitted, dried, and pulverized through a 50-mesh sieve. 10 mg of grape seed, pomegranate seed, or Dendrobium officinale powder and 10 mg of adsorbent Fe3O4@SiO2@PDA-PVP were accurately weighed and ground in an agate mortar for 2 minutes. The mixture was then transferred to a centrifuge tube as much as possible. 2 ml of 60% ethanol aqueous solution was added to the centrifuge tube for ultrasonic elution for 5 minutes. Finally, the eluent and adsorbent were magnetically separated to obtain a polyphenol solution.

[0038] Experimental Example 1 The materials in Example 1 were characterized.

[0039] (1) Scanning electron microscopy (SEM) analysis Scanning electron microscopy (SEM) can directly observe the material properties of the sample surface. Using a field emission environmental scanning electron microscope (FET), Fe3O4 microspheres, Fe3O4@SiO2, Fe3O4@SiO2@PDA, and Fe3O4@SiO2@PDA-PVP sample particles to be analyzed are laid flat and fixed on an aluminum thin plate. The samples are then tested under an accelerating voltage of 3 kV to characterize the morphology and structure of the materials.

[0040] like Figure 1 As shown, the surface of Fe3O4 is relatively rough, with a diameter of 150-180 nm; the surface of Fe3O4@SiO2 is smooth, indicating that silicon dioxide was successfully coated on the Fe3O4 nanoparticles, and the diameter of the Fe3O4@SiO2 microspheres is about 230-260 nm; the thickness of Fe3O4@SiO2@PDA increases by 30-60 nm, and the surface of the spheres becomes rougher, indicating that polydopamine has been successfully synthesized; the surface of Fe3O4@SiO2@PDA-PVP spheres is slightly rough, and the morphology has changed compared to Fe3O4@SiO2@PDA.

[0041] (2) Infrared spectroscopy analysis In this experiment, Fourier transform infrared spectroscopy was used to analyze the synthesized Fe3O4 microspheres, Fe3O4@SiO2, Fe3O4@SiO2@PDA, and Fe3O4@SiO2@PDA-PVP. KBr was used as the blank background, and the spectra obtained were in the range of 4000–450 cm⁻¹. -1 Infrared spectra within the wavenumber range. By observing the absorption peaks of characteristic functional groups in the infrared spectrum of the sample, the success of the synthesis and graft modification of Fe3O4 microspheres can be determined.

[0042] like Figure 2 As shown, this further verifies that Fe3O4 microspheres, Fe3O4@SiO2, Fe3O4@SiO2@PDA, and Fe3O4@SiO2@PDA-PVP have been successfully synthesized. A typical peak is located at approximately 581 cm⁻¹. -1 and 1076cm -1 The values ​​are attributed to the tensile vibrations of the Fe-O and Si-O bonds, respectively, at 1682 cm⁻¹. -1 The peak value at 3404 cm⁻¹ belongs to the C=C stretching vibration in the aromatic ring. -1 The broadband amplitude corresponds to the -NH or -OH stretching vibration, confirming the formation of the PDA shell on Fe3O4@SiO2@PDA. The 1189 cm⁻¹ in the Fe3O4@SiO2@PDA-PVP spectrum... -1 The absorption peak at this point is a characteristic peak of CN stretching vibration, indicating that PVP has been successfully adsorbed onto the Fe3O4@SiO2 spheres wrapped by PDA.

[0043] Experimental Example 2 The polyphenol content in the polyphenol solution obtained in Example 2 was detected.

[0044] (1) Determination of polyphenol content in medicinal materials by the Folin-Ciocalteu method Construction of the gallic acid standard curve: Weigh 0.0010 g of gallic acid standard to prepare a 1.00 mg / mL gallic acid stock solution. Using the gallic acid stock solution, prepare gallic acid working solutions of 10, 20, 30, 40, 50, and 60 μg / mL. Pipette 1 mL of each concentration of working solution into a 10 mL amber volumetric flask, add 1.5 mL of Folin-Ciocalteu reagent, shake well, and let stand for 5 min. Then add 3 mL of 10% Na₂CO₃ solution, and finally add distilled water to make up to volume. Shake well and let stand at room temperature in the dark for 30 min. Measure the absorbance of the gallic acid concentration solutions at 760 nm using a UV spectrophotometer.

[0045] (2) Determination of total polyphenol (TPC) content in medicinal materials Dilute the extracted polyphenol solution 100 times, then pipette 1 mL of the diluted solution into a 10 mL brown volumetric flask, add 1.5 mL of Folin-Ciocalteu reagent, shake well, let stand for 5 min, then add 3 mL of 10% Na₂CO₃ solution, and finally dilute to volume. Incubate in the dark for 1 h, and measure the absorbance at 760 nm. Calculate the total chromatogram (TPC) based on the standard curve. TPC is expressed as mg gallic acid equivalent (GAE) / g dry powder weight (DW).

[0046] (3) Comparison of different adsorption materials for extracting polyphenols from medicinal materials The adsorption capacity of the prepared Fe3O4@SiO2@PDA-PVP was compared with that of its precursors Fe3O4, Fe3O4@SiO2, and Fe3O4@SiO2@PDA, as well as with common dispersants C18, Florisil, and neutral alumina (200-300 mesh). A medicinal material was selected for comparative experiments. 10 mg of pomegranate seed powder was taken, and 10 mg each of the magnetic nano-adsorbent materials Fe3O4@SiO2@PDA-PVP, Fe3O4, Fe3O4@SiO2, Fe3O4@SiO2@PDA, C18, Florisil, and neutral alumina (200-300 mesh) were added to each group, respectively. The mixtures were ground in an agate mortar for 2 min, transferred to centrifuge tubes, and eluted with 2 ml of 60% ethanol aqueous solution for 3 min. The eluent was collected, diluted, and analyzed for polyphenols. The test results are shown in Table 1 and [Table data would be inserted here]. Figure 4 .

[0047] From Table 1 and Figure 4 As can be seen from the comparison of the adsorption capacity of different types of adsorbent materials for polyphenols from medicinal materials, pomegranate seeds were selected as the extraction drug, and it was found that the adsorption capacity of conventional adsorbent materials is relatively weak. Therefore, compared with commonly available adsorbent materials, the Fe3O4@SiO2@PDA-PVP material prepared in this invention has significant advantages for the extraction of polyphenols from pomegranate seeds, and this invention can improve the specific adsorption of the material.

[0048]

[0049] Experimental Example 3 Comparison of polyphenol content extracted from different medicinal materials using different extraction methods The traditional ultrasonic extraction method is as follows: Grape seeds: Weigh 1.00g of grape seed powder, add 45% ethanol solution at a material-to-liquid ratio of 1:25, extract with ultrasound for 60min, filter while hot, centrifuge the grape seed extract filtrate obtained by conventional ultrasound extraction at 5000r / min for 8min to obtain the supernatant, which is used to determine the TPC content.

[0050] Pomegranate seeds: Weigh 1.00g of pomegranate seed powder, add 70% ethanol solution at a material-to-liquid ratio of 1:30, extract by ultrasonication for 40min, filter while hot, centrifuge the pomegranate seed extract filtrate and take the supernatant for the determination of TPC content.

[0051] Dendrobium officinale: Weigh 1.00g of Dendrobium officinale powder, add 60% ethanol solution at a material-to-liquid ratio of 1:20, extract by ultrasonication for 40min, filter while hot, centrifuge the Dendrobium officinale extract filtrate and take the supernatant for the determination of TPC content.

[0052] Through Table 2 and Figure 3 It is evident that the polyphenol content extracted by ultrasound-assisted matrix solid-phase dispersion is higher than that extracted by traditional ultrasound extraction. Matrix solid-phase dispersion adsorbs polyphenols by forming hydrogen bonds between the amide bonds on the surface of magnetic materials and the phenolic hydroxyl groups of polyphenolic compounds. This method has advantages such as low solvent consumption, short extraction time, and fewer impurities in the extract.

[0053]

[0054] Test Example 4 Comparison of the activity of polyphenols extracted from different medicinal materials using different extraction methods To compare the DPPH activity of polyphenols extracted from different medicinal materials using different methods, the extracts of different medicinal materials extracted by different methods were prepared into test solutions of a certain concentration, and the following groups were set up for plate spot detection.

[0055] Control group: 100 µL DPPH solution + 100 µL anhydrous ethanol solution Experimental group: Take 100µL of DPPH solution + 100µL of test solution of different concentrations. Sample blank group: Take 100 μL of test solution + 100 μL of anhydrous ethanol solution Following the above method and conditions, samples were added sequentially in the following order: DPPH, drug solution, and anhydrous ethanol, all in the dark. The 96-well plate was incubated on a shaker at 37°C for 30 min. The absorbance of the samples was measured at 517 nm using a microplate reader, and the scavenging rate of DPPH free radicals for different concentrations was calculated. The IC50 was calculated using SPSS software. 50 value.

[0056] DPPH clearance rate = [(AC) - (BC)] / (AC) × 100% In the formula: A is the absorbance value of the control group; B is the absorbance value of the sample group; C is the absorbance value of the blank sample group.

[0057] Tables 3 and 4 show that the extraction process using adsorption materials not only adsorbs polyphenols but also purifies them. The DPPH in vitro antioxidant assay results show that the IC50 of the Fe3O4@SiO2@PDA-PVP dispersant extract is... 50 IC higher than traditional ultrasonic extraction 50 This may be because the Fe3O4@SiO2@PDA-PVP dispersant can adsorb polyphenolic compounds, increasing the content of the target compound and thus enhancing the DPPH free radical scavenging ability.

[0058]

[0059]

[0060] Therefore, this invention utilizes the above-mentioned Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, its preparation method, and its application. Polyphenol extraction is achieved by grinding the magnetic nano-adsorbent material and traditional Chinese medicine materials using a matrix solid-phase dispersion method. This significantly reduces the amount of organic solvent used, resulting in better environmental friendliness. Furthermore, it improves the extraction of polyphenols from traditional Chinese medicine materials, and the extracted polyphenols also exhibit high efficacy.

[0061] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material, characterized in that: Magnetic nano-adsorbent materials include silica-coated Fe3O4 nanoparticles, polydopamine, and polyvinylpyrrolidone; The preparation method of the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material includes the following steps: (1) Preparation of Fe3O4 nanoparticles Fe3O4 nanoparticles were synthesized using a solvothermal method. (2) Preparation of Fe3O4@SiO2 microspheres Fe3O4 nanoparticles were dispersed in an aqueous ethanol solution to form a suspension. Then, tetraethyl silicate and ammonia were added to the suspension. After the reaction was completed, the mixture was washed and dried to obtain silica-coated Fe3O4 nanoparticles, namely Fe3O4@SiO2 microspheres. (3) Preparation of Fe3O4@SiO2@PDA nanoparticles Fe3O4@SiO2 microspheres were dispersed in a buffer solution, and then dopamine hydrochloride was added. After the reaction was completed, Fe3O4@SiO2@PDA nanoparticles were obtained by magnetic separation, washing, and drying. (4) Preparation of magnetic nano-adsorption materials Fe3O4@SiO2@PDA nanoparticles were dispersed in an aqueous solution of polyvinylpyrrolidone, and then subjected to ultrasonication, washing, and drying to obtain Fe3O4@SiO2@PDA-PVP, which is a magnetic nano-adsorbent material.

2. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 1, characterized in that: The specific preparation process of Fe3O4 nanoparticles in step (1) is as follows: Ferric chloride and sodium acetate were dissolved in ethylene glycol and dispersed by stirring and ultrasonication until a brownish-yellow solution was formed. The brownish-yellow solution was then transferred to an autoclave for a solvothermal reaction. After the reaction was completed, Fe3O4 nanoparticles were obtained by magnetic separation, washing and drying.

3. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 2, characterized in that: The molar ratio of ferric chloride and sodium acetate in step (1) is 1:5 to 10.

4. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 3, characterized in that: In step (1), the temperature of the solvothermal method is 180-220℃ and the time is 5-10h.

5. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 1, characterized in that: In step (2), the ratio of Fe3O4 nanoparticles, tetraethyl silicate and ammonia is 0.1-0.5g: 1-5mL: 1-5mL.

6. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 1, characterized in that: In step (3), the ratio of Fe3O4@SiO2 microspheres to dopamine hydrochloride is 1-5g: 1-5g.

7. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 1, characterized in that: In step (4), the mass ratio of Fe3O4@SiO2@PDA nanoparticles to polyvinylpyrrolidone is 0.1-1.0:1-5.

8. The application of the Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material as described in any one of claims 1 to 7, characterized in that: Application of Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent materials in the extraction process of polyphenols from traditional Chinese medicine materials.

9. The Fe3O4@SiO2@PDA-PVP magnetic nano-adsorbent material according to claim 8, characterized in that: The specific process for polyphenol extraction from traditional Chinese medicine materials is as follows: The traditional Chinese medicine materials and magnetic nano-adsorbent materials are mixed and ground to obtain a mixture. The mixture is then transferred to an ethanol-water solution for ultrasonic elution. After elution, the magnetic nano-adsorbent materials are separated by magnetic separation, and the remaining traditional Chinese medicine materials are removed by filtration to obtain a polyphenol solution.

Images