A residual spray insecticide composition containing piperic acid derivative compounds

Abstract

The invention discloses a residual spray insecticide composition containing a piperic acid derivative compound, wherein the effective components are composed of A and B, wherein A is a piperic acid derivative compound, and B is one or more of high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyfluthrin, and high-efficiency cyfluthrin. The composite weight ratio A:B is 10:1 to 1:2. The binary composition solves the problem of resistance of sanitary pests to pyrethroids, improves the prevention effect, reduces the amount of application, reduces the irritation of application, and prolongs the lasting effect. Component A, as a lethal agent, has no cross-resistance with pyrethroids, has a good lethal effect, and has no repellency to sanitary pests. It is widely used in hotels, schools, factories, farms and other places, and has a special effect on preventing and controlling sanitary pests.

Description

Technical Field

[0001] The invention relates to a residual spray insecticide composition containing a piperic acid derivative compound. The effective ingredients of the residual spray insecticide composition are the piperic acid derivative compound and pyrethroids. The pyrethroids include any one of high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin and high-efficiency cyfluthrin. Background Art

[0002] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity, and can be used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, Coleoptera and other pests.

[0003]

[0004] The structural formula of the compound is as follows:

[0005] Pyrethroids have stomach poison, contact killing and fumigation effects. They are good knockdown agents and lethal agents and are widely used in the field of sanitary external environment space spraying and residual spraying.

[0006] In recent years, the field of residual spraying has seen pain points such as difficulty in completely killing mosquitoes and flies, short or no lasting effect of the pesticide, and other problems. When applying pesticides, the applicators can only increase the dosage and frequency of application, which leads to a significant increase in mosquito and fly resistance, a multiple increase in the cost of application, and an increase in the irritation of the pesticide to the applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to solve these pain points.

[0007] In response to this dilemma, the applicant considered compounding a piperic acid derivative compound with pyrethroids. On the one hand, the two have different mechanisms of action and there is no cross-resistance when combined, which can solve the problem of resistance of sanitary pests to pyrethroids and reduce the amount of pesticides applied. On the other hand, the piperic acid derivative compound has low irritation, which improves the safety of pesticide applicators. Furthermore, research has found that the combination of the two can improve the control effect on sanitary pests, and is a combined drug application technology with good market prospects.

[0008] At the same time, in order to address the problems of persistence and poor lethality to targets such as houseflies, the applicant solved the problem of persistence through formulation technology. By studying the feeding habits of houseflies and adding appetite promoters, the applicant increased the frequency of licking by houseflies, thereby increasing the amount of medicine ingested by houseflies. Summary of the invention

[0009] The technical problem to be solved by the present invention is to provide a residual spray insecticidal composition containing piperic acid derivative compounds in view of the deficiencies in the prior art. The effective ingredients are piperic acid derivative compounds and pyrethroids, and a combination of feeding promoter components is added to improve the efficacy. The residual spray insecticidal composition of the present invention has good insecticidal effect, low drug cost, synergistic effect, is not easy to produce drug resistance, and has a long lasting effect.

[0010] In order to achieve the above object, the present invention adopts the following technical solution:

[0011] The present invention first provides a residual spray insecticide composition containing a piperic acid derivative compound, wherein the active component consists of an active component A and an active component B, wherein the total weight of the active component A and the active component B accounts for 2% to 50% of the insecticide composition, and the remainder is an auxiliary material;

[0012] The active ingredient A is a piperic acid derivative compound represented by formula I (referred to as compound I-72);

[0013] The active ingredient B is selected from any one of high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin, and high-efficiency cyfluthrin;

[0014]

[0015] In the above technical solution, the weight ratio of the active ingredient A to the active ingredient B is 10:1 to 1:2, wherein:

[0016] The weight ratio of the piperic acid derivative compound (I-72) to high-efficiency cypermethrin is 2:1 to 1:2;

[0017] The weight ratio of the piperic acid derivative compound (I-72) to cyfluthrin is 10:1 to 2:1;

[0018] The weight ratio of the piperic acid derivative compound (I-72) to bifenthrin is 4:1 to 2:1;

[0019] The weight ratio of the piperic acid derivative compound (I-72) to deltamethrin is 5:1 to 1:1;

[0020] The weight ratio of the piperic acid derivative compound (I-72) to cis-cypermethrin is 3:1 to 1:1;

[0021] The weight ratio of the piperic acid derivative compound (I-72) to high-efficiency cyhalothrin is 1:1 to 1:2;

[0022] The weight ratio of the piperic acid derivative compound (I-72) to the highly effective flucythrinate is 2:1 to 1:2.

[0023] In the above technical scheme, the residual spray insecticide composition is in the form of wettable powder, water-dispersible granules, suspension, and suspoemulsion; the excipients are any one of emulsifiers, solvents, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, disintegrants, thickeners, binders, appetite promoters, fillers, and water, or a mixture of two or more in any proportion.

[0024] In the above technical scheme, the residual spray insecticide composition, when in the form of a wettable powder, comprises 1%-20% active ingredient A, 1%-20% active ingredient B, 3%-10% dispersant, 1%-5% wetting agent, 10%-30% feeding promoter, and the filler is supplemented to 100%.

[0025] In the above technical scheme, the residual spray insecticide composition, when in the form of water-dispersible granules, comprises 1%-30% active ingredient A, 1%-20% active ingredient B, 5%-12% dispersant, 1%-5% wetting agent, 5%-15% appetite promoter, 2%-10% disintegrant, 0.1%-1% binder, and the filler is supplemented to 100%.

[0026] In the above technical scheme, the residual spray insecticide composition, when the dosage form is a suspension, includes 1%-20% active ingredient A, 1%-20% active ingredient B, 3%-10% dispersant, 1%-5% wetting agent, 0.1%-2% thickener, 2%-15% appetite promoter, 3%-5% antifreeze agent, 0.1%-1% preservative, 0.1%-0.5% defoaming agent, and water is supplemented to 100%.

[0027] In the above technical scheme, the residual spray insecticide composition, when the dosage form is a suspoemulsion, includes 1%-15% active ingredient A, 1%-10% active ingredient B, 5%-15% solvent, 1%-6% emulsifier, 2%-6% dispersant, 1%-5% wetting agent, 0.1%-2% thickener, 3%-5% antifreeze, 0.1%-1% preservative, 0.1%-0.5% defoaming agent, and water is supplemented to 100%.

[0028] In the above scheme, the emulsifier is selected from: styrylphenol polyoxyethylene ether (such as Nongru 600# series), calcium dodecylbenzene sulfonate (such as Nongru 500# of Nanjing Taihua Co., Ltd.), OP series phosphate (alkylphenol polyoxyethylene ether phosphate), phenylphenol polyoxyethyl ether phosphate (such as 600# phosphate of Jiangsu Kaiyuan), styrylphenol polyoxyethylene ether ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, benzyl dimethylphenol polyoxyethyl ether (such as Nongru 400#), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), benzene One or more of ethylphenol polyoxyethyl polypropylene ether (such as Nongru 1600#), ethylene oxide-propylene oxide block copolymer, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether (such as Jiangsu Kaiyuan's EL series), alkylaryl polyoxypropylene polyoxyethylene ether (such as Nanjing Taihua's Nongru 33#), alkylaryl polyoxyethylene polyoxypropylene ether (such as Nanjing Taihua's Nongru 34#), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether), fatty alcohol polyoxyethylene ether (such as Hai'an Petrochemical MOA series).

[0029] In the above scheme, the solvent is selected from: one or more of trimethylbenzene, tetramethylbenzene, pentamethylbenzene, ethanol, cyclohexanone, odorless kerosene, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylhexylamide, N-methylpyrrolidone, diisopropyl adipate, tributyl citrate, acetyl tributyl citrate, ethylene glycol methyl ether, piperonyl butoxide, and dodecylbenzene.

[0030] In the above scheme, the dispersant is selected from: one or more of: sodium salt of polycarboxylate, sodium salt of lignin sulfonate, sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, calcium salt of alkylbenzene sulfonate, sodium salt of naphthalenesulfonic acid formaldehyde condensate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether.

[0031] In the above scheme, the wetting agent is selected from: one or more of alkylbenzene polyoxyethylene ether phosphate, phenylethylphenol polyoxyethylene ether phosphate, alkyl sulfate, sodium alkyl sulfonate, naphthalene sulfonate (such as NNO), sodium dodecyl sulfate, opening powder BX, wetting penetrant F, sodium dodecylbenzene sulfonate, and detergent LS.

[0032] In the above scheme, the defoaming agent can be one or more of silicone oil, polydimethylsiloxane, C8-10 fatty alcohol compounds, and C10-20 saturated fatty acid compounds.

[0033] In the above scheme, the antifreeze agent can be one or more of ethylene glycol, propylene glycol, glycerol, and urea.

[0034] In the above scheme, the preservative is selected from one or more of potassium sorbate and sodium benzoate.

[0035] In the above scheme, the disintegrant is selected from: one or more of ammonium sulfate, sodium sulfate, urea, sodium bicarbonate, and sodium carbonate.

[0036] In the above scheme, the thickener is selected from: one or more of xanthan gum, hydroxyethyl cellulose, and magnesium aluminum silicate.

[0037] In the above scheme, the binder is selected from: one or more of dextrin, methyl cellulose, polyvinyl pyrrolidone, and sodium alginate.

[0038] In the above scheme, the appetite promoter is selected from one or more of fish meal, pork meal, corn meal, sucrose, brown sugar, black sugar, glucose, fructose, maltose, honey and milk flavor.

[0039] In the above scheme, the filler is selected from: one or more of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, starch, and light calcium carbonate.

[0040] The present invention also provides an application of the insecticide composition in the sanitary retention spraying for preventing and controlling sanitary pests in public places.

[0041] In the above technical solution, the public places mentioned refer to places such as hotels, schools, factories or farms. The insecticide composition can show good rapid and long-lasting effects on the semi-absorbent surfaces or absorbent surfaces of these places.

[0042] In the above technical scheme, the sanitary pests are Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassingus, Chironomids, German cockroach, American cockroach, housefly, city fly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia brighten, summer toilet fly, Yuan toilet fly, bed bug, human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas or scabies.

[0043] In the above technical scheme, when the insecticide composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on surfaces such as walls, floors, doors and windows, ceilings and homes in public places, so that the sanitary pests are knocked down and killed when they contact the surface.

[0044] Compared with the existing technology, it has the following characteristics:

[0045] (1) A piperic acid derivative compound is applied to the field of sanitary pest retention spraying;

[0046] (2) The synergistic effect of compounding with pyrethroids is obvious, which improves the lethal effect on sanitary pests and reduces the dosage of pesticides;

[0047] (3) The special formula composition increases the frequency of contact between health pests and the agent, such as increasing the number of licking by houseflies;

[0048] (4) A combination formula of appetite promoters was invented, which has a significant effect of attracting houseflies to lick. DETAILED DESCRIPTION

[0049] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0050] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0051] The laboratory preparation method of wettable powder is as follows: weigh active ingredient A, active ingredient B, wetting agent, dispersant, appetite promoter and filler in proportion, add them into a mixer and mix them evenly, and grind them with a jet mill to obtain the wettable powder.

[0052] The laboratory preparation method of water dispersible granules is as follows: weigh active ingredient A, active ingredient B, wetting agent, dispersant, appetite promoter, disintegrant and filler in proportion, add them into a mixer and mix them evenly, grind them with a jet mill, use the mixer again, add water and a binder mixture, and extrude and granulate them with a granulator.

[0053] The laboratory preparation method of the suspension is as follows: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, appetite promoter, and defoaming agent in proportion, mix well, add active ingredient A and active ingredient B, shear for 5 minutes with a high-speed shearing machine, and then transfer to a sand mill for sand grinding for 2-3 hours to control the particle size D90 below 5μm to obtain the suspension.

[0054] Suspoemulsion: weigh the proposed active ingredient B, solvent, and emulsifier in proportion, add water after complete dissolution, stir evenly, add dispersant, wetting agent, active ingredient A, antifreeze, thickener, preservative, defoamer, mix evenly, shear with a high-speed shearing machine for 5 minutes, and then transfer to a sand mill and sand grind for 2-3 hours to control the particle size D90 below 5μm to obtain the spoemulsion.

[0055] Formulation Example 1: 20% Compound I-72·Cypermethrin Wettable Powder

[0056] Compound I-7210g, highly effective chlorpyrifos 10g, sodium lignin sulfonate 6g, sodium dodecylbenzene sulfonate 4g, brown sugar 8g, milk flavor 2g, fish meal 4g, kaolin to 100g.

[0057] Formulation Example 2: 30% Compound I-72·Cypermethrin Water Dispersible Granules

[0058] Compound I-7220g, highly effective chlorpyrifos 10g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, pull open powder BX 2g, sodium alkyl sulfonate 1g, glucose 10g, sucrose 2g, ammonium sulfate 5g, methyl cellulose 1g, kaolin is supplemented to 100g.

[0059] Formulation Example 3: 6% Compound I-72·Highly Effective Cypermethrin Suspension

[0060] Compound I-722g, highly effective chlorpyrifos 4g, sodium lignin sulfonate 6g, sodium alkyl sulfonate 2g, alkylbenzene polyoxyethylene ether phosphate 1g, magnesium aluminum silicate 1g, xanthan gum 0.3g, fructose 4g, brown sugar 1g, propylene glycol 5g, potassium sorbate 0.5g, polydimethylsiloxane 0.3g, water to 100g.

[0061] Formulation Example 4: 14% Compound I-72·Cyfluthrin Wettable Powder

[0062] Compound I-7212g, chlorfluanidazole 2g, sodium lignin sulfonate 6g, sodium dodecyl sulfate 2g, brown sugar 8g, milk flavor 2g, fish meal 4g, white carbon black 10g, and diatomaceous earth to 100g.

[0063] Formulation Example 5: 22% Compound I-72·Cyfluthrin Water Dispersible Granules

[0064] Compound I-7220g, chlorfluthrin 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 8g, pull open powder BX 2g, sodium lauryl sulfate 2g, brown sugar 5g, milk flavor 1g, sodium sulfate 3g, polyvinyl pyrrolidone 0.5g, white carbon black 6g, kaolin to 100g.

[0065] Formulation Example 6: 12% Compound I-72·Cyfluthrin Suspension

[0066] Compound I-7210g, chlorfluanidine 2g, polycarboxylic acid sodium salt 3g, lignin sulfonate sodium salt 6g, alkyl sodium sulfonate 2g, alkylbenzene polyoxyethylene ether phosphate 1g, xanthan gum 0.3g, maltose 5g, glycerol 3g, potassium sorbate 0.5g, silicone oil 0.3g, water to 100g.

[0067] Formulation Example 7: 15% Compound I-72·Cyclomethrin Suspension Emulsion

[0068] Compound I-7210g, chlorfluanidine 5g, diisopropyl adipate 10g, ethylene oxide-propylene oxide block copolymer 3g, castor oil polyoxyethylene ether 2g, polycarboxylic acid sodium salt 5g, sodium alkyl sulfonate 1g, magnesium aluminum silicate 0.8g, xanthan gum 0.2g, ethylene glycol 3g, potassium sorbate 0.5g, polydimethylsiloxane 0.3g, water to 100g.

[0069] Formulation Example 8: 24% Compound I-72·Bifenthrin Wettable Powder

[0070] Compound I-7216g, bifenthrin 8g, sodium lignin sulfonate 6g, sodium dodecyl sulfate 1g, detergent LS2g, fish meal 15g, corn flour 10g, kaolin to 100g.

[0071] Formulation Example 9: 40% Compound I-72·Bifenthrin Water Dispersible Granules

[0072] Compound I-7230g, bifenthrin 10g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonate sodium salt 6g, detergent LS 2g, sodium lauryl sulfate 2g, sucrose 5g, sodium carbonate 3g, dextrin 0.5g, kaolin to 100g.

[0073] Formulation Example 10: 20% Compound I-72·Bifenthrin Suspension Concentrate

[0074] Compound I-7216g, 4g of cypermethrin, 1g of fatty amine polyoxyethylene ether, 4g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4g of sodium salt of ligninsulfonate, 2g of sodium alkyl sulfonate, 1.5g of magnesium aluminum silicate, 0.3g of xanthan gum, 8g of brown sugar, 2g of milk flavor, 4g of fish meal, 5g of propylene glycol, 0.5g of sodium benzoate, 0.3g of silicone oil, and make up to 100g with water.

[0075] Formulation Example 11: 12% Compound I-72·Deltamethrin Wettable Powder

[0076] Compound I-728g, cypermethrin 4g, lignin sulfonate sodium salt 4g, naphthalenesulfonate formaldehyde condensate sodium salt 5g, detergent LS 2g, pork powder 8g, corn powder 10g, and clay to 100g.

[0077] Formulation Example 12: 30% Compound I-72·Deltamethrin Water Dispersible Granules

[0078] Compound I-7225g, cypermethrin 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 8g, detergent LS 2g, sodium dodecyl sulfate 1g, sucrose 8g, sodium sulfate 3g, sodium alginate 0.5g, kaolin to 100g.

[0079] Formulation Example 13: 5% Compound I-72·Deltamethrin Suspension

[0080] Compound I-72 2.5g, cypermethrin 2.5g, fatty amine polyoxyethylene ether 2g, lignin sulfonate sodium salt 4g, alkyl sulfonate sodium salt 2g, xanthan gum 0.2g, honey 5g, urea 4g, sodium benzoate 0.5g, silicone oil 0.3g, and water to 100g.

[0081] Formulation Example 14: 20% Compound I-72·cis-cypermethrin wettable powder

[0082] Compound I-7210g, cis-cypermethrin 10g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, ligninsulfonic acid sodium salt 4g, detergent LS 2g, sucrose 15g, white carbon black 3g, diatomaceous earth to 100g.

[0083] Formulation Example 15: 50% Compound I-72·cis-cypermethrin water dispersible granules

[0084] Compound I-7230g, cis-cypermethrin 20g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, ligninsulfonic acid sodium salt 8g, pull open powder BX 4g, brown sugar 12g, sodium sulfate 3g, ammonium sulfate 2g, methyl cellulose 0.1g, kaolin to 100g.

[0085] Formulation Example 16: 20% Compound I-72·cis-cypermethrin suspension

[0086] Compound I-7215g, cis-cypermethrin 5g, alkylbenzenesulfonate calcium salt 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium dodecyl sulfate 2g, magnesium aluminum silicate 0.7g, xanthan gum 0.35g, fructose 6g, ethylene glycol 4g, potassium sorbate 0.4g, polydimethylsiloxane 0.2g, water to 100g.

[0087] Formulation Example 17: 18% Compound I-72·L-cyhalothrin wettable powder

[0088] Compound I-726g, highly effective chlorfenapyr 12g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, detergent LS 2g, sodium dodecyl sulfate 1g, glucose 15g, kaolin to 100g.

[0089] Formulation Example 18: 16% Compound I-72·L-cyhalothrin water dispersible granules

[0090] Compound I-728g, highly effective chlorfenapyr 8g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, ligninsulfonic acid sodium salt 5g, pull open powder BX 2g, fish meal 10g, sodium sulfate 8g, polyvinyl pyrrolidone 0.3g, kaolin is supplemented to 100g.

[0091] Formulation Example 19: 12% Compound I-72·L-cyhalothrin suspension

[0092] Compound I-724g, highly effective chlorfenapyr 8g, fatty amine polyoxyethylene ether 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, alkylbenzene polyoxyethylene ether phosphate 2g, xanthan gum 0.2g, honey 4g, propylene glycol 4g, potassium sorbate 0.4g, polydimethylsiloxane 0.3g, and water to 100g.

[0093] Formulation Example 20: 30% Compound I-72·High-efficiency Cyfluthrin Wettable Powder

[0094] Compound I-7215g, highly effective flucythrin 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, lignin sulfonate sodium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, brown sugar 8g, milk flavor 2g, fish meal 4g, and clay supplemented to 100g.

[0095] Formulation Example 21: 45% Compound I-72·Cypermethrin Water Dispersible Granules

[0096] Compound I-7230g, high-efficiency cypermethrin 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, lignin sulfonate sodium salt 8g, detergent LS 3g, sucrose 5g, sodium sulfate 5g, polyvinyl pyrrolidone 0.1g, kaolin to 100g.

[0097] Formulation Example 22: 18% Compound I-72·High-efficiency Cyfluthrin Suspension

[0098] Compound I-726g, highly effective flucythrin 12g, fatty acid polyoxyethylene ester 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, alkylbenzene polyoxyethylene ether phosphate 2g, magnesium aluminum silicate 1.2g, xanthan gum 0.25g, milk flavor 5g, propylene glycol 3g, potassium sorbate 0.5g, silicone compound 0.3g, water to 100g.

[0099] Formulation Example 23: 15% Compound I-72·High-efficiency Cyfluthrin Wettable Powder

[0100] Compound I-72 7.5 g, high-efficiency cypermethrin 7.5 g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5 g, lignin sulfonate sodium salt 2 g, detergent LS 2 g, sodium dodecyl sulfate 1 g, white carbon black 5 g, kaolin to 100 g.

[0101] Application Example 1: Indoor efficacy test for controlling mosquitoes and flies

[0102] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0103] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0104] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0105] Test surface: glass board, varnished wood board, gypsum board;

[0106] Dosage setting: The total concentration of active ingredients in the preparation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0107] Control samples: Control sample 1: 10% compound I-72 wettable powder diluted to 200 mg / l; Control sample 2: 10% highly effective cypermethrin wettable powder diluted to 200 mg / l; Control sample 3: 10% cypermethrin wettable powder diluted to 200 mg / l; Control sample 4: 10% bifenthrin wettable powder diluted to 200 mg / l; The control sample also selected a commercially available mainstream residual spray, control sample 5: 15% cypermethrin·cischlorid wettable powder (Jiangsu Gongcheng Biotechnology Co., Ltd.) diluted to 200 mg / l; Control sample 6: 12% high chlorine·cypermethrin wettable powder (Jiangsu Youjia Plant Protection Co., Ltd.) diluted to 200 mg / l;

[0108] Test results:

[0109] Table 1: Efficacy test of preparation examples against mosquitoes and flies (glass plate)

[0110]

[0111]

[0112] Table 2: Efficacy test of formulation examples against mosquitoes and flies (varnished wooden board)

[0113]

[0114]

[0115] Table 3: Efficacy test of formulation examples against mosquitoes and flies (gypsum board)

[0116]

[0117]

[0118] The test results show that when the dosage is reduced by half, the difference in efficacy between the drugs can be clearly seen on the glass surface. The efficacy of formulation examples 1, 4, 8, 11, 14, 17, and 20 are better than the commercially available control samples 5 and 6 (see Table 1);

[0119] On the semi-absorbent surface varnished wood board and the absorbent surface gypsum board, the efficacy of the preparation examples decreased, mainly because part of the agent was absorbed by the material, resulting in a decrease in the surface agent component. However, judging from the efficacy data, the preparation examples have good persistence. The efficacy lethality of the varnish surface after 30 days can reach more than 75%, and the efficacy lethality of the gypsum surface after 30 days can reach more than 60%, which is better than the commercially available control samples 5 and 6 (see Table 2 and Table 3); compared with control samples 1, 2, 3, and 4, the efficacy of the preparation examples is significantly superior.

[0120] Application Example 2: Determination of the efficacy of the appetizer in the preparation example

[0121] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0122] Test method: Use a 1.2m*1.2**1.2m glass box, dilute the agent, soak it with 20cm*20cm filter paper, dry it and spread it on the glass box, put 30 houseflies in it, and observe the longest stay time and contact frequency of houseflies on the filter paper surface;

[0123] Test drug: Based on the formulation of Preparation Example 23, different appetite promoters and appetite promoter combinations were added;

[0124] Dosage setting: The total concentration of active ingredients is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0125] Table 4 Effect of appetite promoter on the efficacy of housefly

[0126] Addition of appetite stimulants Maximum stay time Contact frequency (10min) KT50 24h mortality rate No Addition 7s 12 62.7min 46.7％ 8g brown sugar + 2g milk flavor + 4g fish meal 25s 64 19.2min 96.7％ 8g brown sugar + 6g milk flavor 18s 52 23.7min 90％ 5g brown sugar + 5g milk flavor + 4g fish meal 22s 59 21.8min 93.3％ 10g brown sugar + 4g fish meal 12s 40 33.2min 83.3％ 14g brown sugar 15s 22 42.9min 63.3％ 14g fish meal 10s 31 51.6min 70％ 14g milk flavor 16s 42 30.6min 76.7％

[0127] The test results show that, based on the formulation of Preparation Example 23, the effects of different appetite promoters on houseflies were tested. By adding brown sugar, milk flavor, and fish meal in a combination of 8:2:4, with a total addition of 14%, the residence time of houseflies on the filter paper surface was significantly increased, the licking frequency of houseflies was increased, and the houseflies ingested more agents, so the final efficacy was better (see Table 4). Different combinations of other appetite promoters also had similar effects.

[0128] Application Example 3: Determination of the co-toxicity coefficient of compound I-72 and pyrethroids

[0129] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0130] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0131] Table 5 Determination of the co-toxicity coefficient of compound I-72 and highly effective cypermethrin (for houseflies)

[0132]

[0133] As shown in Table 5, when the compound I-72 and highly effective chlorpyrifos are mixed in a ratio of 20:1 to 1:10, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the mixing ratio is 1:1, the synergistic effect is most obvious.

[0134] Table 6 Determination of the co-toxicity coefficient of compound I-72 and cyfluthrin (for houseflies)

[0135]

[0136]

[0137] As shown in Table 6, when the compound I-72 and cypermethrin were mixed in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the mixing ratio was 6:1, the synergistic effect was most obvious.

[0138] Table 7 Optimal co-toxicity coefficient of compound I-72 and other pyrethroids (for houseflies)

[0139]

[0140] As can be seen from Table 7, the optimal ratios of compound I-72 and other pyrethroids after compounding are all in the range of 2:1 to 1:2, which has a significant synergistic effect.

[0141] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A residual spray insecticide composition containing a piperic acid derivative compound, characterized in that: The active ingredients are composed of active ingredient A and active ingredient B, and the total weight of active ingredient A and active ingredient B accounts for 2%-50% of the insecticide composition by weight, and the balance is auxiliary materials; The active ingredient A is a piperic acid derivative compound shown in formula I; The active ingredient B is selected from any one of high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin, and high-efficiency cyfluthrin; The weight ratio of the piperic acid derivative compounds to high-efficiency cypermethrin is 2:1-1:2; the weight ratio of the piperic acid derivative compounds to chlorfluthrin is 10:1-2:1; the weight ratio of the piperic acid derivative compounds to bifenthrin is 4:1-2:1; the weight ratio of the piperic acid derivative compounds to deltamethrin is 5:1-1:1; the weight ratio of the piperic acid derivative compounds to cis-cypermethrin is 3:1-1:1; the weight ratio of the piperic acid derivative compounds to high-efficiency chlorfluthrin is 1:1-1:2; the weight ratio of the piperic acid derivative compounds to high-efficiency cypermethrin is 2:1-1:

2.

2. The residual spray insecticidal composition according to claim 1, characterized in that: The residual spray insecticide composition has a dosage form of wettable powder, water-dispersible granules, suspension, and suspoemulsion; the auxiliary materials are any one of emulsifiers, solvents, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, disintegrants, thickeners, binders, appetite promoters, fillers, and water, or a mixture of two or more of them in any proportion.

3. The residual spray insecticidal composition according to claim 2, characterized in that: The residual spray insecticidal composition, when in the form of a wettable powder, comprises 1%-20% active ingredient A, 1%-20% active ingredient B, 3%-10% dispersant, 1%-5% wetting agent, 10%-30% feeding promoter, and the carrier is supplemented to 100%; the residual spray insecticidal composition, when in the form of a water-dispersible granule, comprises 1%-30% active ingredient A, 1%-20% active ingredient B, 5%-12% dispersant, 1%-5% wetting agent, 5%-15% feeding promoter, 2%-10% disintegrant, 0.1%-1% binder, and the carrier is supplemented to 100%.

4. The residual spray insecticidal composition according to claim 2, characterized in that: The residual spray insecticide composition, when the dosage form is a suspension, includes 1%-20% active ingredient A, 1%-20% active ingredient B, 3%-10% dispersant, 1%-5% wetting agent, 0.1%-2% thickener, 2%-15% appetite promoter, 3%-5% antifreeze, 0.1%-1% preservative, 0.1%-0.5% defoamer, and water makes up to 100%; the residual spray insecticide composition, when the dosage form is a suspoemulsion, includes 1%-15% active ingredient A, 1%-10% active ingredient B, 5%-15% solvent, 1%-6% emulsifier, 2%-6% dispersant, 1%-5% wetting agent, 0.1%-2% thickener, 3%-5% antifreeze, 0.1%-1% preservative, 0.1%-0.5% defoamer, and water makes up to 100%.

5. The residual spray insecticidal composition according to claim 2, characterized in that: The appetite promoting agent is selected from one or more of fish meal, pork meal, corn meal, sucrose, brown sugar, black sugar, glucose, fructose, maltose, honey and milk essence.

6. Use of the insecticide composition according to any one of claims 3 to 4 for the prevention and control of sanitary pests by sanitary retention spraying in public places, characterized in that: The sanitary pests are housefly and Culex pipiens pallens.

7. The use according to claim 6, characterized in that: The public places mentioned here refer to hotels, schools, factories or farms.

8. The use according to claim 6, characterized in that: When the insecticide composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on walls, floors, doors, windows, ceilings and home surfaces in public places, so that the sanitary pests are knocked down and killed when they contact the surfaces.

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