Drying equipment and method for pharmaceutical granule production

Abstract

This invention provides a drying device and method for pharmaceutical granule production, including a drying tank, a storage structure, and a feeding structure. The position of the receiving cylinder within the transverse tube is adjusted by an adjusting component, aligning its upper opening with the lower feeding channel of either the first or second storage tank. At this point, a control valve opens, allowing material from the corresponding storage tank to enter the receiving cylinder through the upper opening via the feeding channel. When the control valve closes, a pushing component moves the receiving cylinder within the transverse tube, causing it to move towards the drying tank. Material in the receiving cylinder, aided by an inclined block, quickly falls into the drying tank from the lower opening. This allows for the selection of different materials to be added to the drying tank for drying, making it very convenient.

Description

Technical Field

[0001] This invention relates to a drying equipment for pharmaceutical granule production, specifically to a technology that allows for the selection of different materials for drying as needed. Background Technology

[0002] In the pharmaceutical industry, granules are granular medications made by mixing drug ingredients with excipients. They have good flowability and rapid solubility, making them convenient for patients to take. Granules can contain a single drug ingredient or a mixture of multiple drug ingredients.

[0003] After the drug granules are prepared, they usually need to be dried to remove excess moisture and ensure their stability and flowability.

[0004] Fluidized bed drying equipment is a very common and important type of drug particle drying equipment in existing technology. For example... Figure 7 The diagram shows an existing fluidized bed drying device, which mainly includes an air inlet unit 1, a heater 2, a drying tank 3, a feeding unit 4, a cyclone separator 5, and a dry material recovery unit 6. The air inlet unit 1 delivers airflow from the bottom, which is heated by the heater 2 and then enters the drying tank 3 from the bottom to dry and boil the material inside. The boiled dry material gradually flows out from the upper middle side opening, and a portion of the material flows out from the top opening with the airflow. The airflow from the top opening is separated by the cyclone separator 5 to obtain dry material for recovery.

[0005] However, the existing particle drying equipment uses a conveyor belt to feed the drying tank. The conveyor belt exposes the particle material to the environment, and the feed inlet is not sealed, which easily causes heat loss and material spillage. Furthermore, it is difficult to switch the drying material after using the existing feeding method for a period of time. Summary of the Invention

[0006] To address the problems existing in the above-mentioned technologies, the present invention provides a technology that allows for the selection of different materials for drying as needed; and a technology that achieves a better sealing effect at the feeding position.

[0007] The present invention provides a drying device for pharmaceutical granule production, comprising a drying tank, a storage structure, and a feeding structure;

[0008] The drying tank has an outlet at the upper end and an inlet at the lower end. A horizontal pipe is provided on one side of the drying tank, and an arc-shaped notch is provided on one side of the horizontal pipe.

[0009] The storage structure is installed on the horizontal pipe. The storage structure includes a first storage tank and a second storage tank. The discharge channels at the lower ends of the first storage tank and the second storage tank are respectively connected to the horizontal pipe. Control valves are installed on both discharge channels.

[0010] The feeding structure is located on one side of the transverse tube. The feeding structure includes a receiving cylinder, a pushing component, and an adjusting component. An inclined block is provided inside the receiving cylinder. The upper end of the receiving cylinder has an upper opening, and the lower end of the receiving cylinder has a lower opening. The receiving cylinder is movably located inside the transverse tube. The pushing component is used to drive the receiving cylinder to move inside the transverse tube, and the adjusting component is used to adjust the position of the receiving cylinder inside the transverse tube. The pushing component and the adjusting component cooperate with each other.

[0011] The aforementioned beneficial effects are as follows: by adjusting the position of the receiving cylinder within the transverse tube using the adjusting component, the upper opening aligns with the lower discharge channel of the first or second storage tank. At this point, the control valve opens, allowing material from the corresponding storage tank to enter the receiving cylinder through the upper opening via the discharge channel. When the control valve closes, the pushing component moves the receiving cylinder within the transverse tube, causing it to move towards the drying tank. The material in the receiving cylinder, through the action of the inclined block, quickly falls into the drying tank from the lower opening. This allows for the selection of different materials to be added to the drying tank for drying, which is very convenient.

[0012] In a preferred embodiment, the pushing assembly includes a turntable, a gear, and a driving rod. The turntable has a circular opening at its front end and a T-shaped block at its lower end. The gear is rotatably disposed within the circular opening. The outer end of the driving rod is rotatably connected to the outer side of the gear, and the inner end of the driving rod is rotatably connected to the receiving cylinder. The adjusting assembly includes a moving plate, a spring structure, a telescopic column, and a limiting plate. The moving plate is disposed within a vertical groove at the front end of the T-shaped block, and the vertical groove communicates with the circular opening. The telescopic column is disposed at the lower end of the moving plate, and its lower end passes through the lower end of the vertical groove. The spring structure is sleeved on the telescopic column, and its two ends are respectively connected to the lower end of the moving plate and the bottom of the vertical groove. The limiting plate is disposed at the upper end of the moving plate. The turntable is disposed at the front end of the L-shaped plate, and the L-shaped plate is connected to the outer wall of the drying cylinder.

[0013] A preferred embodiment is that the lower end of both storage tanks is provided with a square tube, one side of which is connected to an air inlet pipe, and each side of the directional tube is provided with multiple air outlets, with a circular filter screen installed at the air outlet.

[0014] In a preferred embodiment, the L-shaped plate has a first rod, a second rod, and a plate. The first and second rods are detachably configured. The plate is attached to the outer end of the second rod. The inner end of the first rod is connected to the outer wall of the drying cylinder. The turntable is located at the front end of the plate. A motor is located at the rear end of the plate. The output shaft of the motor passes through the plate and is connected to the turntable. Two ear plates are provided at the inner end of the second rod. Each ear plate has an insertion hole. A connection hole is provided at the outer end of the first rod.

[0015] The working method of the drying equipment for pharmaceutical granule production provided by the present invention includes the following steps;

[0016] The upper opening of the receiving cylinder is adjusted to be below the discharge channel at the lower end of the first storage cylinder by the adjustment component. When the control valve is opened, material in the first storage cylinder enters the receiving cylinder through the upper opening from the discharge channel. Then, the control valve is closed, and the receiving cylinder is moved by the pushing component along the horizontal pipe into the drying tank. Once inside the drying tank, the material in the receiving cylinder quickly falls into the drying tank through the lower opening due to the inclined block inside the receiving pipe. Alternatively, the upper opening of the receiving cylinder can be adjusted to be below the discharge channel at the lower end of the second storage tank by the adjustment component. When the control valve is opened, material in the second storage tank enters the receiving cylinder through the upper opening from the discharge channel. When the control valve is closed, the pushing component moves the receiving cylinder again, moving it along the horizontal pipe into the drying tank. Once inside the drying tank, the material in the receiving cylinder falls into the drying tank through the lower opening. This allows for the selection of different materials for drying, which is very convenient.

[0017] The working method of the drying equipment for pharmaceutical granule production provided by the present invention includes the following steps;

[0018] The operator pulls down the telescopic column, causing the moving plate to move downwards. The moving plate moves the limiting plate out from between the two teeth of the gear, and at the same time, the spring structure retracts. The operator then rotates the gear, which rotates within the circular opening, causing the driving rod to move the receiving cylinder within the horizontal tube. The upper opening of the adjustable receiving cylinder is located below the discharge channel at the lower end of the corresponding first or second storage tank. Afterwards, the operator releases the telescopic column, the spring structure extends, and the moving plate moves the limiting plate upwards. The limiting plate then enters between the two teeth, preventing the gear from rotating. At this point, the motor drives the turntable to rotate, which in turn drives the driving rod through the gear to rotate. The driving rod then moves the receiving cylinder within the horizontal tube. Once the receiving cylinder reaches the drying tank, the material inside falls quickly into the drying tank through the lower opening via the inclined block. The material is then dried in the drying tank.

[0019] The working method of the drying equipment for pharmaceutical granule production provided by the present invention includes the following steps;

[0020] When adding material from one storage tank to the drying tank for drying, if the material in the other storage tank is stored in the storage tank for a long time, clumping may occur. This can cause blockage when material is fed into the receiving cylinder. In this case, the two air inlet pipes are connected to the air inlet pipes, and the other end of the air inlet pipes is connected to the fan. The fan forces air to flow sequentially from the air inlet pipe, the air inlet pipe, and the square pipe, and then into the storage tank through the air outlet to ventilate the material in the storage tank and prevent clumping.

[0021] The working method of the drying equipment for pharmaceutical granule production provided by the present invention includes the following steps;

[0022] When it is necessary to remove the receiving cylinder from the transverse tube, unscrew the nut from the bolt and remove the bolt from the connecting hole and the insertion hole, thereby separating the second rod from the first rod and removing the receiving cylinder from the transverse tube. This facilitates subsequent cleaning of the transverse tube. When connecting, insert the receiving cylinder into the transverse tube, insert the bolt into the insertion hole and the connecting hole, and then tighten the nut on the bolt. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the structure of a drying device for pharmaceutical granule production according to the present invention;

[0024] Figure 2 This is a partial structural schematic diagram of a drying device for pharmaceutical granule production according to the present invention;

[0025] Figure 3 This is a partial structural schematic diagram of a drying device for pharmaceutical granule production according to the present invention;

[0026] Figure 4 yes Figure 3 Enlarged structural diagram of area A in the middle;

[0027] Figure 5 This is a partial top view of a drying device for pharmaceutical granule production according to the present invention.

[0028] Figure 6 yes Figure 2 Enlarged structural diagram of region B;

[0029] Figure 7 This is a schematic diagram of the structure of an existing fluidized bed drying device;

[0030] Figure 8 This is a partial structural schematic diagram of a drying device for pharmaceutical granule production according to the present invention. Detailed Implementation

[0031] First embodiment:

[0032] like Figure 1 and Figure 2 As shown, the present invention provides a drying device for pharmaceutical granule production, including a drying tank 10, a storage structure 20 and a feeding structure 30;

[0033] The upper end of the drying tank 10 is provided with an outlet 11, which is used to connect the pipeline and the cyclone separator on the downstream side. The upper side of the drying tank 10 has a material outlet (not shown in the figure). The lower end of the drying tank 10 is provided with an inlet 12. A horizontal pipe 13 is provided on one side of the drying tank 10, and an arc-shaped notch 14 is provided on one side of the horizontal pipe 13.

[0034] Drying tank 10 is used in Figure 7 The connection relationship and working process of the drying tank 10 with other equipment in the drying equipment shown are existing technologies and will not be described in detail here. The innovation of this invention revolves around the side feeding method of the drying tank 10, and therefore this structure will be described in detail below.

[0035] The storage structure 20 is installed on the transverse pipe 13. The storage structure 20 includes a first storage tank 21 and a second storage tank 22. The discharge channels 23 at the lower ends of the first storage tank 21 and the second storage tank 22 are respectively connected to the transverse pipe 13. Control valves are installed on both discharge channels 23.

[0036] The feeding structure 30 is disposed on one side of the transverse tube 13. The feeding structure 30 includes a receiving cylinder 31, a pushing component 310, and an adjusting component 320. An inclined block 32 is disposed inside the receiving cylinder 31. An upper opening 33 is provided at the upper end of the receiving cylinder 31, and a lower opening 34 is provided at the lower end of the receiving cylinder 31. The receiving cylinder 31 is movably disposed inside the transverse tube 13. The pushing component 310 is used to drive the receiving cylinder 31 to move inside the transverse tube 13. The adjusting component 320 is used to adjust the position of the receiving cylinder 31 inside the transverse tube 13. The pushing component 310 and the adjusting component 320 cooperate with each other.

[0037] The upper opening 33 of the receiving cylinder 31 is adjusted to be below the discharge channel 23 at the lower end of the first storage cylinder 21 by the adjusting component 320. The material in the first storage cylinder 21 enters the receiving cylinder 31 through the upper opening 33 from the discharge channel 23 by opening the valve. Then the valve closes, and the receiving cylinder 31 moves along the horizontal pipe 13 into the drying tank 10 by the pushing component 310. After entering the drying tank 10, the material in the receiving cylinder 31 quickly falls into the drying tank 10 through the lower opening 34 due to the inclined block 32 inside the receiving cylinder 31. Alternatively, by adjusting component 320, the upper opening 33 of receiving cylinder 31 can be adjusted to be below the discharge channel 23 at the lower end of the second storage tank 22. By controlling the valve to open, the material in the second storage tank 22 enters the receiving cylinder 31 through the upper opening 33 via the discharge channel 23. The valve is then closed, and the receiving cylinder 31 is moved again by pushing component 310. The receiving cylinder 31 moves along the transverse pipe 13 into the drying tank 10. After it moves into the drying tank 10, the material in the receiving cylinder 31 falls into the drying tank 10 through the lower opening 34. In this way, different materials can be selected for drying as needed, which is very convenient.

[0038] In addition, the inlet 12 facilitates the delivery of hot air into the drying tank 10, while the outlet 11 facilitates the discharge of the dried material.

[0039] By using this device, better quantitative material feeding can be achieved. That is, through the specific volume of the receiving cylinder 31, the material can be received at the receiving position and then pushed to the drying tank 10 for unloading. According to the set time program, material receiving and unloading can be performed periodically, so that the feeding can be completed within the specified time as needed, so as to better complete the feeding.

[0040] Furthermore, since the receiving cylinder 31 forms a piston-like motion, it provides a good seal for the feeding position of the drying cylinder 10, avoiding heat loss and material overflow caused by being in an open state for a long time. The movement of the receiving cylinder 31 not only completes the receiving and unloading of materials, but also basically maintains the sealing of the connection between the transverse pipe 13 and the drying tank 10 during the movement.

[0041] Second embodiment:

[0042] like Figure 3 and Figure 4The pushing component 310 includes a turntable 311, a gear 312, and a driving rod 313. The turntable 311 has a circular opening 314 at its front end and a T-shaped block 315 at its lower end. The gear 312 is rotatably disposed within the circular opening 314. The outer end of the driving rod 313 is rotatably connected to the outer side of the gear 312, and the inner end of the driving rod 313 is rotatably connected to the receiving cylinder 31. The adjusting component 320 includes a moving plate 321, a spring structure 322, a telescopic column 323, and a limiting plate 324. The moving plate 321 is disposed within the T-shaped block 315. The vertical groove 3151 at the front end of block 315 communicates with the circular opening 314. The lower end of the moving plate 321 is provided with the telescopic column 323. The lower end of the telescopic column 323 passes through the lower end of the vertical groove 3151. The spring structure 322 is sleeved on the telescopic column 323. The two ends of the spring structure 322 are respectively connected to the lower end of the moving plate 321 and the bottom of the vertical groove 3151. The limiting plate 324 is provided at the upper end of the moving plate 321. The turntable 311 is provided at the front end of the L-shaped plate 319. The L-shaped plate 319 is connected to the outer wall of the drying cylinder 10.

[0043] By pulling down the telescopic column 323, the operator moves the movable plate 321 downwards. The movable plate 321 causes the limiting plate 324 to move out from between the two teeth 3121 of the gear 312. At the same time, the spring structure 322 retracts. Then, the operator rotates the gear 312, which rotates within the circular opening 314. This causes the driving rod 313 to move the receiving cylinder 31 within the transverse tube 13. The upper opening 33 of the adjustable receiving cylinder 31 is located below the discharge channel 23 at the lower end of the corresponding first storage tank 21 or second storage tank 22. Afterward, the operator releases the telescopic column 323, and the spring structure 322 extends. The moving plate 321 causes the limiting plate 324 to move upward, and the limiting plate 324 enters between the two teeth 3121, preventing the gear 312 from rotating. At this time, the motor drives the turntable 311 to rotate, and the turntable 311 drives the driving rod 313 to rotate through the gear 312. The driving rod 313 then drives the receiving cylinder 31 to move. The receiving cylinder 31 moves inside the transverse tube 13. When the receiving cylinder 31 moves into the drying tank 10, the material in the receiving cylinder 31 falls quickly into the drying tank 10 through the inclined block 32 and the lower opening 34. Then, the material is dried by the drying tank 10.

[0044] The working principle of this device is further explained below: The rotation center 316 of the turntable 311 is located in the lower middle position, not at the exact location of the turntable 311. This rotation center 316 is close to the lower moving plate 321. When the driving rod 313 moves with the gear 312, that is, after the gear 312 rotates to different positions through the engagement of the limiting plate 324, the position of the driving rod 313 relative to the rotation center 316 changes. This change causes the movement amplitude of the driving rod 313 to change; that is, the greater the eccentricity, the greater the movement amplitude, and the smaller the eccentricity, the smaller the movement amplitude. Therefore, when it is necessary to adjust the movement amplitude, the engagement position of the gear 312 and the limiting plate 324 can be adjusted. In this way, as needed, by adjusting the movement amplitude, when the upper opening 33 moves to the leftmost position for receiving materials, it can move precisely to the position of the discharge channel 23 at different positions for receiving materials, thereby switching between different materials for conveying and drying.

[0045] Third embodiment:

[0046] like Figure 2 and Figure 5 As shown, a square tube 51 is provided at the lower end of each of the two storage tanks. One side of the square tube 51 is connected to the air inlet pipe 52. Each side pipe 53 of the directional tube 51 is provided with multiple air outlets, and a circular filter screen is provided at the position of the air outlet.

[0047] When material is added to the drying tank 10 from one storage tank for drying, if the material in the other storage tank is stored in the storage tank for a long time, clumping may occur. When material is fed into the receiving cylinder 31, blockage may occur. At this time, the two air inlet pipes 52 are connected to the air inlet pipes respectively, and the other end of the air inlet pipes is connected to the fan. The fan makes the air flow from the air inlet pipe, the air inlet pipe 52, and the square pipe 51 in sequence, and then enter the storage tank through the air outlet, so as to ventilate the material in the storage tank and prevent the material in the storage tank from clumping.

[0048] By installing a circular filter screen at the air outlet, material is prevented from entering the air outlet.

[0049] Fourth embodiment:

[0050] like Figure 2 and Figure 8As shown, the L-shaped plate 319 has a first rod 91, a second rod 92, and a plate 93. The first rod 91 and the second rod 92 are detachably configured. The plate 93 is located at the outer end of the second rod 92. The inner end of the first rod 91 is connected to the outer wall of the drying cylinder 10. The turntable 311 is located at the front end of the plate 93. A motor 94 is located at the rear end of the plate 93. The output shaft of the motor 94 passes through the plate 93 and is connected to the turntable 311. The inner end of the second rod 92 is provided with two ear plates 95, each of which has an insertion hole. The outer end of the first rod 91 is provided with a connection hole.

[0051] When it is necessary to remove the receiving cylinder 31 from the transverse tube 13, unscrew the nut 97 from the bolt 98 and remove the bolt 98 from the connecting hole and the insertion hole, so that the second rod 92 is separated from the first rod 91, and the receiving cylinder 31 is removed from the transverse tube 13, which facilitates subsequent cleaning of the transverse tube 13. When connecting, let the receiving cylinder 31 enter the transverse tube 13, insert the bolt 98 into the insertion hole and the connecting hole, and screw the nut 97 on the bolt 98.

Claims

1. A drying device for pharmaceutical granule production, characterized in that, include: A drying tank, wherein the upper end of the drying tank is provided with an outlet, the lower end of the drying tank is provided with an inlet, a horizontal pipe is provided on one side of the drying tank, and an arc-shaped notch is provided on one side of the horizontal pipe; The storage structure is installed on the horizontal pipe. The storage structure includes a first storage tank and a second storage tank. The discharge channels at the lower ends of the first storage tank and the second storage tank are respectively connected to the horizontal pipe. Control valves are installed on both discharge channels. A feeding structure is provided on one side of a transverse tube. The feeding structure includes a receiving cylinder, a pushing component, and an adjusting component. An inclined block is provided inside the receiving cylinder. The upper end of the receiving cylinder has an upper opening, and the lower end of the receiving cylinder has a lower opening. The receiving cylinder is movably disposed inside the transverse tube. The pushing component is used to drive the receiving cylinder to move inside the transverse tube, and the adjusting component is used to adjust the position of the receiving cylinder inside the transverse tube. The pushing component and the adjusting component cooperate with each other. The pushing component includes a turntable, a gear, and a driving rod. The turntable has a circular opening at its front end and a T-shaped block at its lower end. The gear is rotatably mounted inside the circular opening. The outer end of the driving rod is rotatably connected to the outer side of the gear, and the inner end of the driving rod is rotatably connected to the receiving cylinder. The adjusting component includes a moving plate, a spring structure, a telescopic column, and a limiting plate. The moving plate is located in a vertical groove at the front end of the T-shaped block, and the vertical groove communicates with the circular opening. The telescopic column is located at the lower end of the moving plate, and its lower end passes through the lower end of the vertical groove. The spring structure is sleeved on the telescopic column, and its two ends are connected to the lower end of the moving plate and the bottom of the vertical groove, respectively. The limiting plate is located at the upper end of the moving plate. The turntable is located at the front end of the L-shaped plate, and the L-shaped plate is connected to the outer wall of the drying tank.

2. The drying equipment for pharmaceutical granule production according to claim 1, characterized in that, Both storage tanks have a square tube at their lower end. One side of the square tube is connected to an air inlet pipe. Each side of the square tube has multiple air outlets, and a circular filter screen is installed at each air outlet.

3. The drying equipment for pharmaceutical granule production according to claim 2, characterized in that, The L-shaped plate has a first rod, a second rod, and a plate. The first rod and the second rod are detachably connected. The plate is attached to the outer end of the second rod. The inner end of the first rod is connected to the outer wall of the drying tank. The turntable is located at the front end of the plate. A motor is located at the rear end of the plate. The output shaft of the motor passes through the plate and is connected to the turntable. The inner end of the second rod has two ear plates, each with an insertion hole. The outer end of the first rod has a connection hole.

4. The working method of the drying equipment for pharmaceutical granule production according to claim 3, characterized in that, Includes the following steps; The upper opening of the receiving cylinder is adjusted to be below the discharge channel at the lower end of the first storage tank by the adjusting component. When the control valve is opened, material from the first storage tank enters the receiving cylinder through the upper opening from the discharge channel. Then, the control valve is closed, and the receiving cylinder is moved by the pushing component along the horizontal pipe into the drying tank. Once inside the drying tank, the material in the receiving cylinder quickly falls into the drying tank through the lower opening due to the inclined block inside the receiving cylinder. Alternatively, the upper opening of the receiving cylinder can be adjusted to be below the discharge channel at the lower end of the second storage tank by the adjusting component. When the control valve is opened, material from the second storage tank enters the receiving cylinder through the upper opening from the discharge channel. When the control valve is closed, the pushing component moves the receiving cylinder again, moving it along the horizontal pipe into the drying tank. Once inside the drying tank, the material in the receiving cylinder falls into the drying tank through the lower opening. This allows for the selection of different materials for drying, which is very convenient.

5. The operating method of the drying equipment for pharmaceutical granule production according to claim 4, characterized in that, Includes the following steps; The operator pulls down the telescopic column, causing the moving plate to move downwards. The moving plate moves the limiting plate out from between the two teeth of the gear, and at the same time, the spring structure retracts. The operator then rotates the gear, which rotates within the circular opening, causing the driving rod to move the receiving cylinder within the horizontal tube. The upper opening of the adjustable receiving cylinder is located below the discharge channel at the lower end of the corresponding first or second storage tank. Afterwards, the operator releases the telescopic column, the spring structure extends, and the moving plate moves the limiting plate upwards. The limiting plate then enters between the two teeth, preventing the gear from rotating. At this point, the motor drives the turntable to rotate, and the turntable, through the gear, drives the driving rod to rotate. The driving rod then moves the receiving cylinder within the horizontal tube. Once the receiving cylinder reaches the drying tank, the material inside falls quickly into the drying tank through the lower opening via the inclined block. The material is then dried in the drying tank.

6. The operating method of the drying equipment for pharmaceutical granule production according to claim 5, characterized in that, Includes the following steps; Two air inlet pipes are connected to the air inlet pipe, and the other end of the air inlet pipe is connected to the fan. The fan makes the air pass through the air inlet pipe, the air inlet pipe, and the square pipe in sequence, and then enter the storage tank through the air outlet to ventilate the material in the storage tank and prevent the material in the storage tank from clumping.

7. The operating method of the drying equipment for pharmaceutical granule production according to claim 6, characterized in that, Includes the following steps; When it is necessary to remove the receiving cylinder from the transverse tube, unscrew the nut from the bolt and remove the bolt from the connecting hole and the insertion hole, thereby separating the second rod from the first rod and removing the receiving cylinder from the transverse tube. This facilitates subsequent cleaning of the transverse tube. When connecting, insert the receiving cylinder into the transverse tube, insert the bolt into the insertion hole and the connecting hole, and then tighten the nut on the bolt.

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