A medicinal food for adjuvant treatment of acne, a preparation method, a composition and an application thereof

Abstract

The present application relates to a kind of medicine food for treating acne, preparation method, composition and application, medicine food is by sweet almond, Chinese yam, wax gourd seed, lily, fuzilong, jasmine, lotus seed, prepared wumei flesh, safflower, cypress seed, sweet leaf chrysanthemum and prepared yuzi, which are safe medicine of food and medicine composition;Preparation method is to be ground into fine powder, stir-fried, mixed to obtain;Composition includes medicine food for treating acne and peroxide benzoyl;The above medicine food is applied to the preparation of medicine food for treating acne;The medicine food for treating acne of the present application is more explicit than the curative effect of traditional Chinese medicine, more suitable in taste, more harmonious in nature and taste, convenient to serve, more suitable for long-term use.

Description

Technical Field

[0001] This invention belongs to the field of food and pharmaceutical technology, specifically relating to a medicinal diet, preparation method, composition, and application for the adjunctive treatment of acne. Background Technology

[0002] Current acne treatments primarily utilize a combination of traditional Chinese medicine and Western medicine, with relatively significant efficacy. However, because acne is often caused by factors such as a preference for spicy foods, irregular eating habits, inconsistent sleep patterns, and imbalances in Qi, many patients experience relapses after discontinuing medication. How to help "sub-healthy" individuals maintain treatment efficacy, adjust the body's Yin-Yang balance, clear phlegm and dampness, and regulate the spleen and stomach—from the perspective of TCM's "prevention of disease"—to reduce recurrence, is a question that medical professionals need to consider. Research shows that previous dietary therapy for acne focused primarily on clearing heat and removing dampness. However, for patients in cold northern regions or those with a weak constitution, long-term use of heat-clearing and dampness-removing dietary therapies not only fails to improve symptoms but can also easily damage Yang Qi and worsen the condition. Furthermore, many heat-clearing and dampness-removing herbs have unpleasant tastes, tending towards bitterness, resulting in poor acceptance. Therefore, from the perspective of TCM dietary therapy mechanisms, a dietary formula that is mild in nature and flavor, palatable, has clear efficacy, and is convenient for long-term use should be our research direction. Summary of the Invention

[0003] This invention provides a medicinal diet, preparation method, composition, and application for adjuvant treatment of acne, which solves the problems of current Western medicines for treating acne, which may contain hormones and are prone to recurrence, and Chinese medicines, which have a bitter taste, poor acceptance by the public, and can easily damage the yang qi and aggravate the condition if taken for a long time.

[0004] A medicinal diet for the adjunctive treatment of acne contains the following components in parts by weight: 25-35 parts sweet almonds, 5-15 parts yam, 10-20 parts winter melon seeds, 2-8 parts lily bulbs, 5-15 parts poria cocos, 5-15 parts jasmine flowers, 5-15 parts lotus seeds, 2-8 parts prepared dried plum pulp, 2-8 parts safflower, 1-5 parts cypress seed kernels, 2-8 parts stevia, and 0-2 parts prepared polygonatum.

[0005] Furthermore, the medicinal diet comprises the following components in parts by weight: 28-32 parts sweet almonds, 8-12 parts yam, 12-18 parts winter melon seeds, 4-6 parts lily bulbs, 8-12 parts poria cocos, 8-12 parts jasmine flowers, 8-12 parts lotus seeds, 4-6 parts prepared dried plum pulp, 4-6 parts safflower, 2-4 parts cypress seed kernels, 4-6 parts stevia, and 0.5-1.5 parts prepared polygonatum.

[0006] Furthermore, the medicinal diet contains the following components in parts by weight: 30 parts sweet almonds, 10 parts yam, 15 parts winter melon seeds, 5 parts lily bulbs, 10 parts poria cocos, 10 parts jasmine flowers, 10 parts lotus seeds, 5 parts prepared dried plum pulp, 5 parts safflower, 3 parts cypress seed kernels, 5 parts stevia, and 1 part prepared polygonatum.

[0007] Sweet almonds are sweet and mild in nature, moistening the lungs and replenishing deficiencies, resolving phlegm and soothing the stomach, and treating consumptive cough and asthma.

[0008] Yam benefits kidney qi, strengthens the spleen and stomach, stops diarrhea and dysentery, resolves phlegm and saliva, and moisturizes the skin and hair.

[0009] Winter melon seeds clear the lungs and resolve phlegm, reduce swelling and drain pus, and promote diuresis.

[0010] Lily bulbs are sweet in taste and slightly cold in nature. They primarily enter the lung and heart meridians and are used to nourish yin and moisten the lungs, clear the heart and calm the mind, and relieve irritability and depression.

[0011] Poria cocos has a sweet and bland taste, and is neutral in nature. It promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind.

[0012] Jasmine flowers are warm in nature, pungent and slightly sweet in taste, and enter the spleen, stomach and liver meridians. They dispel cold accumulation, harmonize the middle and lower qi, and soothe the liver and relieve depression.

[0013] Lotus seeds are sweet and neutral in nature. They are mainly used to nourish the middle jiao (spleen and stomach), calm the mind, boost energy, eliminate various diseases, and long-term consumption can lighten the body, promote longevity, and prevent hunger.

[0014] Ume plum flesh is sour, astringent, and neutral in nature. It enters the liver, spleen, lung, and large intestine meridians, and nourishes the liver, moistens dryness, and nourishes yin and astringes the liver.

[0015] Safflower is sweet in taste and neutral in nature. It enters the heart and liver meridians and promotes blood circulation, removes blood stasis, cools the blood and detoxifies, relieves depression and calms the mind.

[0016] The kernel of cypress seed is sweet and neutral in nature, and enters the heart, kidney, and large intestine meridians. It is used to treat palpitations, soothe the five internal organs, replenish qi, and eliminate wind-dampness. Long-term use can make one's skin smooth, improve complexion, and sharpen hearing and vision.

[0017] Stevia is sweet and neutral in nature, and it can quench thirst, strengthen the spleen, and resolve phlegm. It has a sweet and refreshing taste and is suitable for people with high blood pressure and high blood sugar. It is characterized by high sweetness, low calories, and no toxic side effects; its sweetness is 300 times that of sucrose.

[0018] Polygonatum rhizome is sweet and neutral in nature, and enters the spleen, lung, and kidney meridians. It tonifies qi, nourishes yin, strengthens the spleen, moistens the lungs, and benefits the kidneys. It also soothes the stomach, invigorates qi, harmonizes the five internal organs, and strengthens muscles.

[0019] A method for preparing a medicinal diet to assist in the treatment of acne involves grinding each ingredient into a fine powder, stir-frying it, and then mixing them together.

[0020] Furthermore, the particle size of the finely ground powder is greater than 120 mesh.

[0021] Furthermore, during use, take one tablespoon of the fine powder of the above-mentioned medicinal diet recipe, mix it with water and drink it. Those with a cold constitution can add brown sugar and milk; those who like sweets but have a hot constitution can add rock sugar.

[0022] A composition comprising a medicinal diet for adjunctive treatment of acne, and further comprising benzoyl peroxide.

[0023] Application of a medicinal diet for adjuvant treatment of acne, the medicinal diet being used to prepare a medicinal diet for adjuvant treatment of acne.

[0024] The beneficial effects of this invention are:

[0025] 1. During the development of this product, the pathogenesis of acne, which occurs on the skin, is analyzed based on the underlying mechanisms of phlegm and dampness accumulation, spleen deficiency and liver hyperactivity, and dampness and blood stasis. This product provides a medicinal diet that promotes lung function and eliminates phlegm, strengthens the spleen and soothes the liver, invigorates blood and removes blood stasis, has a fragrant aroma and a light, sweet and sour taste, and is not significantly hot or cold in nature, making it widely applicable. The aim is to help improve the cure rate of acne, reduce the recurrence rate of acne, regulate the body constitution, improve the visual appearance of the skin, and prevent the recurrence of the condition after patients stop drug treatment.

[0026] 2. Before the product was developed, we analyzed the prescriptions and medicines for treating acne in ancient books and screened out a batch of safe medicines that are both food and medicine. This made the product taste more suitable, its properties more mild, and it was easier to take. It is more suitable for long-term use and does not harm Yang Qi.

[0027] 3. Compared with Western medicine for treating acne, this product has the advantages of being safe and hormone-free, having good therapeutic effect, and low recurrence rate. Compared with traditional Chinese medicine for treating acne, it has the advantages of better taste, convenient use (just brew it, no need to decoct it), good therapeutic effect, low recurrence rate, and long-term use (the ingredients that are both food and medicine are safer) by adding sweet almond, jasmine, stevia and other ingredients. Detailed Implementation

[0028] Example 1

[0029] The medicinal diet contains the following components in parts by weight: 30 parts sweet almonds, 10 parts yam, 15 parts winter melon seeds, 5 parts lily bulbs, 10 parts poria cocos, 10 parts jasmine flowers, 10 parts lotus seeds, 5 parts prepared dried plum pulp, 5 parts safflower, 3 parts cypress seed kernels, 5 parts stevia, and 1 part prepared polygonatum.

[0030] The above raw materials are ground into fine powder using a grinder, and then stir-fried in a wok until slightly yellow. The powder is then mixed in proportion to obtain medicinal food powder.

[0031] Example 2

[0032] The medicinal diet is the same as in Example 1. Take 5g of the medicinal diet prepared according to the above formula each morning and evening, mix it with water and drink it. The treatment lasts for one month.

[0033] At the same time, the patient was given a non-hormonal Western medicine, benzoyl peroxide, applied topically to the affected area, and its usage and dosage were in accordance with the instructions.

[0034] Comparative Example 1

[0035] The components of Example 1 were prepared into a decoction as follows: 15g sweet almond, 5g yam, 7.5g winter melon seeds, 2.5g lily bulb, 5g poria cocos, 5g jasmine flower, 5g lotus seed, 2.5g prepared dried plum pulp, 2.5g safflower, 1.5g cypress seed, 2.5g stevia, and 0.5g prepared polygonatum. Decoct in water to make a decoction of 200-300ml. This is one dose, taken once a day, twice a day, morning and evening. Treatment lasts for one month.

[0036] At the same time, the patient was given a non-hormonal Western medicine, benzoyl peroxide, applied topically to the affected area, and its usage and dosage were in accordance with the instructions.

[0037] One month later, the therapeutic effect achieved in Comparative Example 1 was comparable to that achieved in Example 2, but the amount of materials used was far greater than that in Example 2, which was wasteful, indicating that decoctions are not as economical as powders.

[0038] Example 3

[0039] Inclusion criteria: Age 18-45 years, both male and female. Acne distributed on the face, chest, and back sebaceous glands, mainly manifested as follicular papules, pustules, nodules, cysts, blackheads, and scars, accompanied by seborrhea, with a course of disease >1 month. No history of other skin diseases. Before administering this medicinal diet to patients, explain the efficacy and usage of the formula in detail. If patients currently have other Western medical treatments for acne, they can continue to follow them; during the period of taking this medicinal diet, do not take other Chinese herbal preparations orally.

[0040] A total of 107 patients were included in the study, comprising 48 males and 59 females, distributed across Hebei and Guangdong provinces. They were divided into three groups, with balanced gender and age distribution among the groups.

[0041] The control group consisted of 18 males and 20 females. The control group used the non-hormonal Western medicine benzoyl peroxide topically applied to the affected area, and the usage and dosage were in accordance with the instructions.

[0042] The medicinal diet group consisted of 17 males and 27 females. The group received topical application of the non-hormonal Western medicine benzoyl peroxide to the affected area, following the instructions for use and dosage (the same as the control group). In addition, they received oral administration of a medicinal diet powder prepared according to the following weight proportions: 30 parts sweet almond, 10 parts yam, 15 parts winter melon seeds, 5 parts lily bulb, 10 parts poria cocos, 10 parts jasmine flower, 10 parts lotus seed, 5 parts prepared dried plum pulp, 5 parts safflower, 3 parts arborvitae seed, 5 parts stevia, and 1 part prepared polygonatum. Each patient took 5g of the above-mentioned medicinal diet powder twice daily, morning and evening, dissolved in water, for one month. Other lifestyle habits, such as medication, meals, and water intake, remained unchanged.

[0043] The conventional Chinese medicine (TCM) group consisted of 13 males and 12 females. The conventional TCM group received topical application of the non-hormonal Western medicine benzoyl peroxide (Banzac) to the affected area, following the instructions for use and dosage (maintaining the same as the control group). In addition, they received oral administration of a TCM formula prepared according to the following weight proportions: Bupleurum chinense 15g, Schizonepeta tenuifolia 15g, Saposhnikovia divaricata 15g, Forsythia suspensa 30g, Platycodon grandiflorus 10g, Mentha haplocalyx 5g, Angelica dahurica 10g, Citrus aurantium 10g, Glycyrrhiza uralensis 5g, Coptis chinensis 5g, Scutellaria baicalensis 10g, Phellodendron chinense 10g, Gardenia jasminoides 10g, Rehmannia glutinosa 15g, Angelica sinensis 10g, Ligusticum chuanxiong 10g, and Paeonia lactiflora 10g. One dose was taken daily, decocted in water and taken warm in two divided doses. Treatment lasted one month. Other lifestyle habits, such as eating and drinking, remained unchanged. During the period of taking this medicinal diet, no other TCM preparations were taken orally simultaneously.

[0044] Before treatment and one month after treatment, patients were followed up using the Personal Wellbeing Index (PWI), an international scale developed by Professor Cummins of Deakin University, Australia, to assess whether their self-perceived well-being had improved. The criteria for determining efficacy were: Cured: Rash subsided by more than 90%, or only a small amount of pigmentation remained; Significantly effective: Rash subsided by 60%–89%; Effective: Rash subsided by 30%–59%; Ineffective: Rash subsided by less than 30% or even worsened, with new lesions appearing. Simultaneously, cured patients were followed up one month after discontinuation of medication to collect information on disease recurrence and well-being index.

[0045] The results are as follows:

[0046] Comparison before treatment and 1 month after treatment

[0047] Group cure Effective Improvement invalid Overall efficiency control group 12 14 6 6 84.2％ medicinal diet group 17 18 6 3 93％ Common Chinese medicine group 8 9 7 1 96％

[0048] Relapse rate 1 month after stopping medication

[0049] Group relapse No recurrence recurrence rate control group 4 8 33.3％ medicinal diet group 4 13 23.5％ Common Chinese medicine group 2 6 25％

[0050] Comparison of happiness index 1 month after treatment

[0051] Group <![CDATA[Total average value * > control group 54.80 medicinal diet group 64.20 Common Chinese medicine group 58.40

[0052] *Intergroup difference P<0.01

[0053] As can be seen from the above, the treatment method of this invention can effectively improve the cure rate of acne, reduce the recurrence rate, and enhance the happiness index. Compared with the application of ancient classic prescriptions with modifications, the cure rate and recurrence rate are lower but relatively close. At the same time, this medicinal diet can better improve the patient's happiness index and enhance their quality of life.

[0054] Example 4

[0055] Typical Case: Ms. Li, female, 30 years old. The patient had intermittent acne on her face, chest, and back for many years, accompanied by enlarged pores on the back of her neck and back. She frequently worked overtime and stayed up late, and had a 5-year history of alcohol consumption. She had previously tried various Chinese and Western medicines, which provided some relief, but the acne recurred upon discontinuation, and the enlarged pores showed no significant improvement. At the time of consultation, papules and pustules were visible on her face, chest, and back, predominantly on her back, with symptoms worsening before menstruation. She was prescribed a non-hormonal Western medicine, benzoyl peroxide, applied topically to the affected areas, following the instructions for use and dosage. She was also prescribed an oral medicinal diet prepared according to the following weight proportions: 28 parts sweet almond, 12 parts yam, 16 parts winter melon seeds, 6 parts lily bulb, 8 parts poria cocos, 8 parts jasmine, 8 parts lotus seeds, 6 parts prepared dried plum pulp, 6 parts safflower, 4 parts cypress seed, 3 parts stevia, and 1.5 parts prepared polygonatum.

[0056] Take 5g of the above-mentioned medicinal diet twice a day, morning and evening, and dissolve it in water. Continue this treatment for one month. Maintain your usual lifestyle habits, such as eating and drinking. Do not take other Chinese herbal preparations orally during the period of taking this medicinal diet.

[0057] After one month of treatment, the patient reported a significant reduction in acne, with no new acne appearing. Occasionally, one or two new acne lesions would appear before her menstrual period. The enlarged pores on her back improved, and the "chicken skin" phenomenon around her shoulders also significantly improved. Her skin was whiter, smoother, and fuller than before. When interacting with friends, many praised her for her recently whiter and smoother skin, which boosted her self-confidence, improved her mood, and enhanced her quality of life. One month after discontinuing the medication, there was no recurrence of acne. She felt her skin fullness had decreased slightly, but it was still better than before.

[0058] Example 5

[0059] Mr. Wang, male, 18 years old. He had intermittent acne on his face and back of the neck for many years, with enlarged facial pores, significant mental stress, irregular eating habits, and sticky stools. At the time of consultation, scattered acne was visible on his face, with some pustules and pustular lesions at the tips. He was prescribed topical non-hormonal Western medicine, combined with a one-month oral diet made from the following ingredients in the indicated weight proportions: sweet almonds 26 parts, yam 14 parts, winter melon seeds 20 parts, lily bulbs 3 parts, poria cocos 6 parts, jasmine flowers 14 parts, lotus seeds 14 parts, prepared dried plum pulp 3 parts, safflower 3 parts, cypress seed 4 parts, stevia 7 parts, and prepared polygonatum 0 parts.

[0060] Take 5g of the above-mentioned medicinal diet twice a day, morning and evening, and dissolve it in water. Continue this treatment for one month. Maintain your usual lifestyle habits, such as eating and drinking. Do not take other Chinese herbal preparations orally during the period of taking this medicinal diet.

[0061] The patient's family reported that after one month, there were virtually no new acne breakouts, existing acne significantly decreased, no pustules were observed, and enlarged pores improved. The patient was noticeably more relaxed, with improved appetite and bowel movements, and became more optimistic and cheerful. No acne recurrence was observed one month after discontinuing medication, although one or two pimples occasionally appeared after consuming spicy food.

[0062] Those skilled in the art should understand that the discussion of any of the above embodiments is merely exemplary and is not intended to imply that the scope of this disclosure (including the claims) is limited to these examples; within the framework of this disclosure, the technical features of the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other variations of different aspects of one or more embodiments of this application as described above, which are not provided in detail for the sake of brevity.

[0063] One or more embodiments in this application are intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of one or more embodiments in this application should be included within the scope of protection of this disclosure.

Claims

1. A medicinal diet for the adjunctive treatment of acne, characterized in that, The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet hollyhock 2-8 parts, prepared Rhizoma Polygonati 0-2 parts.

2. The medicated diet of claim 1, wherein the medicated diet is a medicated diet for a pet. The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet hollyhock 2-8 parts, prepared Rhizoma Polygonati 0-2 parts.

3. The medicated diet of claim 2, wherein the medicated diet is a medicated diet for a chicken. The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet hollyhock 2-8 parts, prepared Rhizoma Polygonati 0-2 parts.

4. A method of preparing a medicated diet for the adjunctive treatment of acne according to any one of claims 1 to 3, characterised by, The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet hollyhock 2-8 parts, prepared Rhizoma Polygonati 0-2 parts.

5. The method of preparing the medicated diet for the adjuvant treatment of acne according to claim 4, characterized in that, The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet hollyhock 2-8 parts, prepared Rhizoma Polygonati 0-2 parts.

6. A composition characterized in that, The application discloses a medicine food for treating acne, which is prepared from the following components in parts by weight: sweet almond 25-35 parts, Chinese yam 5-15 parts, wax gourd seed 10-20 parts, lily 2-8 parts, poria 5-15 parts, jasmine 5-15 parts, lotus seed 5-15 parts, prepared Fructus Mume 2-8 parts, safflower 2-8 parts, Platycladi Seed 1-5 parts, sweet 7. The use of a medicated diet as claimed in any one of claims 1 to 3 for the adjuvant treatment of acne, characterized in that, ​