A gel composition for beauty and skin care and preparation method thereof

Abstract

The present invention discloses a gel composition for beauty and skin care and a preparation method thereof. The gel composition comprises water, 1,3-butylene glycol, sorbitan olivate, allantoin, carbomer, squalane and modified cyclodextrin, wherein the modified cyclodextrin is prepared from methyl beta-cyclodextrin, a grafting agent, a modifier and a synergist. The modified cyclodextrin is blended with other basic raw materials to obtain a gel composition. Compared with the prior art, the gel composition prepared by the present invention has the advantages of extending the timeliness of beauty and skin care, having a good moisturizing effect and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of beauty and skin care, and in particular to a method for beauty and skin care and a preparation method thereof. Background Art

[0002] Beauty and skin care have always been a hot topic of concern. With the advancement of technology and the increasing demand of consumers for skin care products, various new skin care products have emerged on the market. Among them, gel compositions, as a new type of skin care product, have been loved by consumers for their unique texture and efficacy. Gel compositions are transparent or translucent colloids that usually have a refreshing texture and are easy to absorb. This composition usually contains rich moisturizing ingredients that can penetrate deep into the skin, provide sufficient moisture to the skin, and keep the skin hydrated. In addition, gel compositions often contain a variety of plant extracts and antioxidants, which can help the skin resist damage from free radicals, delay skin aging, and make the skin younger and more elastic.

[0003] In the field of beauty and skin care, gel compositions have a wide range of applications. They can be used as basic products for daily skin care, such as moisturizing gel, cleansing gel, etc., or as special care products, such as acne gel, whitening gel, etc. These products can provide personalized solutions for different skin problems and meet the needs of different consumers.

[0004] CN111920711A discloses a gel composition and its preparation method and application, wherein the gel composition includes a polyol, an emulsifier and grease, wherein the emulsifier is selected from at least one of di(laurylamide glutamine) sodium lysine, PEG-20 glyceryl triisostearate and subtilisin sodium. The beneficial effects of the invention are as follows: the present invention selects a suitable type of emulsifier to be matched with a polyol and grease to form a specific gel formula. When removing makeup with the gel composition, a good cleaning effect can be exerted on a variety of makeup product types, that is, it has universality, and there is no need to use corresponding cleaning products for different makeup product types. In addition, the inventors have also found that the gel formula also has the advantage of good stability. However, the gel composition prepared by the method is prone to skin dehydration and dryness after excessive cleaning.

[0005] CN116270289B discloses an ion gel composition containing hydrolyzed actin and a preparation method thereof. The invention discloses an ion gel composition containing hydrolyzed actin and a preparation method thereof, and belongs to the field of cosmetics. The product uses an ion gel prepared from a specific ionic liquid as a carrier to load hydrolyzed actin, which can not only effectively improve the stability and long-term effectiveness of hydrolyzed actin, but also the ion gel itself can also enhance the moisturizing and hydrating effect of the skin together with the hydrolyzed actin, and has a synergistic effect on the hydrolyzed actin; the product has a soothing effect, good biocompatibility, high safety for the human body, and a strong sense of use. However, the raw material of the gel composition prepared by the method uses hydrolyzed actin as a bioactive substance, and its stability may be affected by various factors, such as temperature, pH value, light, etc. If the preparation process is improperly controlled or it is not properly preserved during use, the activity of the hydrolyzed actin may be reduced or inactivated, thereby affecting the skin care effect of the gel. Summary of the invention

[0006] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to improve the moisturizing effect of the gel composition used for beauty and skin care and to prolong the beauty and skin care time of the gel composition.

[0007] To achieve the above-mentioned object, the present invention provides a gel composition for beauty and skin care, which comprises the following components in parts by weight: 10-50 parts of water, 5-10 parts of 1,3-butylene glycol, 3-10 parts of sorbitan olivate, 4-8 parts of allantoin, 1-5 parts of carbomer, 5-15 parts of squalane and 3-15 parts of modified cyclodextrin, wherein the modified cyclodextrin is prepared from methyl beta-cyclodextrin, a grafting agent, a modifier and a synergist.

[0008] Preferably, the preparation method of the modified cyclodextrin comprises the following steps:

[0009] S1. Dissolve methyl beta-cyclodextrin in sodium hydroxide solution, leave overnight, add p-toluenesulfonyl chloride, stir at 0-5°C for 2-4h, filter the mixture, mix with grafting agent and N,N-dimethylformamide in acetic acid solution, stir at 80-100°C and 200-300rpm for 20-30h, then cool to 45-60°C, add glycidyl trimethylammonium chloride and stir at 200-300rpm for 4-7h, dialyze for 3-7h, cut off molecular weight 3000-3500Da, freeze-dry to obtain a mixture;

[0010] S2. Add a modifier and a synergist to the mixture prepared in S1, and then stir at 200-300 rpm for 30-60 min at room temperature to obtain modified cyclodextrin.

[0011] More preferably, the preparation method of the modified cyclodextrin comprises the following steps, in parts by weight:

[0012] S1. Dissolve 2-10 parts of methyl beta-cyclodextrin in 80-100 parts of sodium hydroxide solution, place for 24-30 hours, add 1-5 parts of p-toluenesulfonyl chloride, stir at 0-5°C for 2-4 hours, filter the mixture, mix the filtrate with 2-8 parts of grafting agent and 30-60 mL of N,N-dimethylformamide in 40-80 mL of 1-3 wt% acetic acid solution, stir at 80-100°C at 200-300 rpm for 20-30 hours, then cool to 45-60°C, add 5-12 parts of glycidyl trimethylammonium chloride, stir at 50-70°C at 200-300 rpm for 4-7 hours, dialyze for 3-7 hours, cut off molecular weight 3000-3500 Da, freeze-dry, and obtain quaternary ammonium cyclodextrin grafted chitosan;

[0013] S2. Add 2-10 parts of a modifier and 1-3 parts of a synergist to the quaternized cyclodextrin grafted chitosan prepared in S1, and then stir at 200-300 rpm for 30-60 min at room temperature to obtain modified cyclodextrin.

[0014] Preferably, the grafting agent is any one of 6'-amino-tetra-N-ethoxycarbonyl kanamycin B, 6'-C-aminomethyl-1,3,2',3"-tetra(N-tert-butyloxycarbonyl)-3',4'-dideoxy kanamycin C, and hydroxypropyl chitosan.

[0015] Preferably, the modifier is any one of sodium hyaluronate, sodium citrate, sodium oleate, and sodium salt of D-glucuronic acid.

[0016] More preferably, the modifier is sodium salt of D-glucuronic acid.

[0017] Preferably, the mass fraction of the sodium hydroxide solution is 8-12wt%.

[0018] Preferably, the enhancer is a mixture of one or more of retinol, peptide, bosine, niacinamide and yeast extract.

[0019] A gel composition for beauty and skin care and a preparation method thereof, comprising the following steps, measured in parts by weight:

[0020] Step 1, 10-50 parts of water, 5-10 parts of 1,3-butylene glycol, 3-10 parts of sorbitan olivate, 4-8 parts of allantoin, 1-5 parts of carbomer, and 5-15 parts of squalane are mixed at 200-300 rpm for 20-30 minutes to obtain an emulsion;

[0021] Step 2: Add 3-15 parts of modified cyclodextrin to the emulsion prepared in step 1 and stir at 200-300 rpm to form a transparent gel, thereby obtaining a beauty and skin care gel composition.

[0022] In this recipe, the ingredients and their functions are as follows:

[0023] Water: Water is the main solvent in the gel composition, used to dissolve or disperse other ingredients, such as 1,3-butylene glycol, sorbitan olivate, allantoin, carbomer and squalane. These ingredients can form a uniform mixture in water, providing a basis for subsequent gel preparation. The water content has an important influence on the consistency of the gel. By adjusting the proportion of water, the fluidity and spreadability of the gel can be controlled, making it more suitable for use as a beauty and skin care product.

[0024] 1,3-Butanediol: 1,3-Butanediol is an excellent moisturizer that can absorb and retain a large amount of water, thereby helping the skin stay moisturized. It can increase the hydration of the skin and reduce water loss, making the skin softer and smoother. 1,3-Butanediol has a certain degree of permeability, which can help other ingredients in the gel penetrate deeper into the skin and improve the skin care effect.

[0025] Sorbitan olivate: Sorbitan olivate is rich in vitamin E and unsaturated fatty acids, which have a good moisturizing effect on the skin. When applied to the skin, it can help relieve dry skin and keep the skin moisturized. Sorbitan olivate is often used as an emulsifier in cosmetics and skin care products, which helps to stabilize the dispersion and mixing of other ingredients, improve the stability and use effect of the product.

[0026] Allantoin: Allantoin can strengthen the skin's ability to retain moisture, help the skin resist the erosion of a dry environment, and keep the skin moisturized and elastic. It can be added to various moisturizing cosmetics, such as facial cleansers, hand creams, skin care lotions, etc., to provide a long-lasting moisturizing effect. Allantoin can change the structure of proteins in the stratum corneum, making it soft, helping to remove excess keratin cells, prevent pores from being clogged, and help improve skin quality. In addition, allantoin also helps the hydrophilicity of keratin molecules, further promoting the softening and improvement of the stratum corneum.

[0027] Carbomer: Carbomer can form a stable gel network structure, making the gel less likely to flow and separate, thereby improving the stability of the gel. Carbomer has excellent moisturizing ability. It can absorb a large amount of water and lock it in the gel, allowing the gel to retain moisture in the skin for a long time.

[0028] Squalane: Squalane is a lipid that is very close to human sebum, so it has a strong affinity and can blend with the human body's own sebum membrane, thereby forming a natural barrier on the skin surface, effectively preventing the invisible loss of moisture. This characteristic makes squalane have excellent moisturizing ability, can lock in moisture, enhance the skin's moisturizing ability, and make the skin soft and moisturized.

[0029] Methyl Beta-Cyclodextrin: One of the main functions of methyl beta-cyclodextrin is to serve as a base substance for gel formation. Through interaction with other components, it can effectively transform liquid into a solid gel with a stable three-dimensional network structure. This transformation not only gives the gel a stable morphology, but also captures solute molecules and prevents them from moving freely, thereby further enhancing the stability of the gel. The methyl beta-cyclodextrin portion can be used to incorporate hydrophobic molecules into the cavity. By using methyl beta-cyclodextrin for grafting reaction with a grafting agent and then quaternizing it with glycidyl trimethylammonium chloride to obtain a new polymer, the sustained release ability of the hydrophobic molecules is improved, which is beneficial to prolong the cosmetic effect of the gel composition.

[0030] p-Toluenesulfonyl chloride: During the preparation of modified cyclodextrin, p-toluenesulfonyl chloride reacts with methyl beta-cyclodextrin to generate specific chemical bonds. This reaction is a key step in the preparation of modified cyclodextrin, which can change the physical and chemical properties of cyclodextrin, thereby improving its performance and stability in the gel composition. Therefore, p-toluenesulfonyl chloride plays an important role in the preparation of the gel composition, and affects the overall quality and effect of the gel composition by participating in the synthesis of modified cyclodextrin. At the same time, due to its specific reactivity and activity of p-toluenesulfonyl chloride, the modified cyclodextrin has unique properties and functions, which further enhances the application value and effect of the gel composition.

[0031] Grafting agent: Grafting agent is one of the raw materials for preparing modified cyclodextrin. Grafting agent is not easily soluble in water, and the grafting agent skeleton shows positive charge, which can improve the adhesion and antibacterial properties of the gel composition. Grafting agent can react chemically with methyl beta-cyclodextrin to introduce new side chains or functional groups. These side chains or functional groups can change the molecular weight, physical properties and chemical properties of the polymer, thereby improving its performance in the beauty and skin care gel composition.

[0032] N,N-dimethylformamide: N,N-dimethylformamide is an excellent non-protonic polar solvent that can dissolve most organic and inorganic substances. Therefore, as a solvent, it can dissolve methyl-beta-cyclodextrin, grafting agent and other components well to ensure the smooth progress of the reaction.

[0033] Glycidyl trimethyl ammonium chloride: Glycidyl trimethyl ammonium chloride can further react with the polymer formed by the grafted methyl beta-cyclodextrin to obtain a quaternary ammonium polymer. With the intervention of glycidyl trimethyl ammonium chloride, the cationic group is grafted on the polymer surface, the alkyl chain becomes longer, and the polymer's ability to capture the synergist is improved.

[0034] Modifier: Modifiers are sodium salts, and their main function is to chemically modify cyclodextrin, thereby changing its original physical and chemical properties to meet specific application requirements. This modification can enhance the inclusion capacity of modified cyclodextrin, enabling it to better encapsulate and stabilize active ingredients.

[0035] Synergists: The main function of synergists is to enhance the efficacy of beauty and skin care ingredients so that they can work better. For example, when a synergist is combined with certain active ingredients, it can change the chemical structure or mode of action of these ingredients, thereby improving their permeability, stability and biological activity. In this way, skin care ingredients can penetrate deeper into the skin more effectively and exert anti-aging, repair, moisturizing and other effects. For example: retinol is widely used in skin care to promote collagen synthesis, improve wrinkles, brighten skin tone, etc.

[0036] Beneficial effects of the present invention:

[0037] Compared with the prior art, the modified cyclodextrin is prepared by grafting the grafting agent onto methyl beta-cyclodextrin, reacting with the modifier to form a polymer, and then coating the synergist. Finally, the modified cyclodextrin is blended with other raw materials to prepare a gel composition. The modified cyclodextrin increases the delivery effect of the skin delivery synergist, and also plays a good role in sustained release, thereby extending the beauty and skin care time of the gel composition. DETAILED DESCRIPTION

[0038] Parameters for specific chemical substances used, sources.

[0039] 6'-Amino-tetra-N-ethoxycarbonylkanamycin B, CAS No.: 67733-64-6.

[0040] 6'-C-aminomethyl-1,3,2',3"-tetrakis(Nt-butoxycarbonyl)-3',4'-dideoxykanamycin C, CAS No.: 133036-48-3.

[0041] Hydroxypropyl chitosan: CAS number: 35061-50-8.

[0042] D-Glucuronic acid sodium salt, CAS number: 14984-34-0.

[0043] Example 1

[0044] A gel composition for beauty and skin care and a preparation method thereof, comprising the following steps:

[0045] Step 1: 30 g of water, 6 g of 1,3-butylene glycol, 8 g of sorbitan olivate, 8 g of allantoin, 2 g of carbomer, and 10 g of squalane were mixed together, and mixed at 200 rpm for 30 min to obtain an emulsion;

[0046] Step 2: Add 15 g of modified cyclodextrin to the emulsion prepared in step 1 and stir at 300 rpm for 2 h to obtain a beauty and skin care gel composition.

[0047] Wherein, the preparation method of the modified cyclodextrin comprises the following steps:

[0048] S1. Dissolve 10 g of methyl beta-cyclodextrin in 100 mL of 10 wt% sodium hydroxide aqueous solution, place for 24 h, add 2 g of p-toluenesulfonyl chloride, stir at 0 ° C for 2 h, filter the mixture, mix the filtrate with 8 g of hydroxypropyl deacetylated chitosan and 30 mL of N, N-dimethylformamide in 50 mL of 1.5 wt% acetic acid solution, and stir at 95 ° C at 200 rpm for 24 h; continue to add 5 g of glycidyl trimethylammonium chloride and stir at 52 ° C at 200 rpm for 6 h, dialyze with a cellulose dialysis bag for 5 h, with a molecular weight cutoff of 3000-3500 Da, and freeze-dry at -10 ° C for 20 min to obtain quaternary ammonium cyclodextrin grafted chitosan;

[0049] S2. Add 8 g of modifier D-glucuronic acid sodium salt and 2 g of retinol to the quaternized cyclodextrin grafted chitosan prepared in S1, and then stir at 200 rpm for 30 min at 25° C. to obtain modified cyclodextrin.

[0050] Example 2

[0051] The difference between Example 2 of the present application and Example 1 is that the sodium salt of D-glucuronic acid in S2 is replaced by sodium hyaluronate.

[0052] Example 3

[0053] The difference between Example 3 of the present application and Example 1 is that the sodium salt of D-glucuronic acid in S2 is replaced by sodium citrate.

[0054] Example 4

[0055] The difference between Example 4 and Example 1 of the present application is that the sodium salt of D-glucuronic acid in S2 is replaced by sodium oleate.

[0056] Example 5

[0057] The difference between Example 5 of the present application and Example 1 is that the hydroxypropyl deacetylated chitosan in S1 is replaced by 6'-amino-tetra-N-ethoxycarbonyl kanamycin B.

[0058] Example 6

[0059] The difference between Example 6 of the present application and Example 1 is that the hydroxypropyl deacetylated chitosan in S1 is replaced by 6'-C-aminomethyl-1,3,2',3"-tetra(N-tert-butyloxycarbonyl)-3',4'-dideoxykanamycin C.

[0060] Comparative Example 1

[0061] The difference between Comparative Example 1 and Example 1 is that the sodium salt of D-glucuronic acid in S2 is replaced by sodium alginate.

[0062] Comparative Example 2

[0063] The difference between Comparative Example 2 and Example 1 is that the hydroxypropyl chitosan in S1 is replaced by chitosan.

[0064] Test Example 1

[0065] Moisturizing effect performance test: The gel compositions obtained in the above embodiments and comparative examples are used separately, and their moisturizing and synergistic ability is tested with a CK test instrument. The test method is as follows: first, the test area should be marked on the inside of both arms, and the moisture content of the marked area is measured with a CK tester. Then, equal amounts of the above samples are applied to the marked areas on the inside of the arms, and the moisture content values ​​at 30min, 60min, and 120min are measured. Finally, the moisturizing effect is expressed by subtracting the value tested before applying the sample from the value tested after applying the sample. The larger the value, the better the moisturizing effect. The test results are shown in Table 1:

[0066] Table 1 Moisturizing effect performance test

[0067] Experimental groups 30min / % 60min / % 120min / % Example 1 32.24 34.67 20.51 Example 2 28.19 31.75 17.47 Example 3 27.86 30.58 16.07 Example 4 28.83 31.87 17.48 Example 5 24.71 27.96 13.79 Example 6 23.84 26.49 13.05 Comparative Example 1 17.64 20.48 9.48 Comparative Example 2 18.49 21.04 10.53

[0068] Test Example 2

[0069] Gel composition stability test: heat resistance means placing the present invention in a 48°C constant temperature box for 120 days; refrigeration means placing the present invention in a 0-5°C constant temperature box for 120 days; cold resistance means placing the present invention in a -8 to -18°C constant temperature box for 120 days; normal temperature means placing the present invention in a normal temperature (25°C) environment for 1 year, and finally observing whether the present invention has obvious oil-water separation. If there is no obvious oil-water separation, the stability passes. The test results are shown in Table 2:

[0070] Table 2 Gel composition stability test

[0071]

[0072]

[0073] By observing the moisturizing effect performance test data in Table 1, it can be seen that among Examples 1-6 and Comparative Examples 1-2, the moisture content of Example 1 is the highest, indicating that the moisturizing effect of the gel composition for beauty and skin care prepared in Example 1 is the best. Compared with the moisturizing effect test results of Examples 1-4 and Comparative Example 1, it is found that the moisturizing effect values ​​are different, and the reason for these data differences may be the use of different modifiers. The role of the modifier is the sodium carboxylate in the modifier, which provides hydration and normalizes keratinization for the skin. At the same time, the sodium salt contained in the modifier combines with the chloride ions contained in the quaternized cyclodextrin polymer through electrostatic action to form a polyelectrolyte nanocomplex, which can significantly increase the water retention capacity of the skin. In addition to sodium carboxylate, the modifier in Example 1 also contains an aldehyde functional group. The oxygen atoms in the aldehyde group can form hydrogen bonds with water molecules, thereby attracting and fixing a large number of water molecules. This hydrogen bonding effect enables the prepared gel composition to absorb and retain a large amount of water, thereby forming a moist moisturizing film on the skin surface, effectively preventing the loss of water. The aldehyde group can further react with the hydroxyl group in the grafting agent, further increasing the molecular cross-linking degree of the modified cyclodextrin, while also further improving the hydrophobic effect of the modified cyclodextrin, thereby utilizing electrostatic bonding with the hydrophilic enhancer substance to improve the beauty and skin care effect of the gel composition.

[0074] Compared with the moisturizing effect performance test data results in Example 1, Example 5-6 and Comparison 2, the moisturizing effect of the gel composition for beauty and skin care prepared in Example 1 is the best. The comparison found that different grafting agents were used. The grafting agent itself is not easily soluble in water, but after the grafting agent is cross-linked with methyl beta-cyclodextrin and then quaternized with glycidyl trimethyl ammonium chloride, the water solubility of the obtained polymer is significantly enhanced. The grafting agent in Example 1 contains a hydroxypropyl group. The introduction of the hydroxypropyl group weakens the hydrogen bonding force within and between the grafting agent molecules, and improves the water solubility of the grafting agent. The hydroxypropyl group is a hydrophilic group with excellent water absorption and moisturizing ability. In the gel composition, the hydroxypropyl group of hydroxypropyl deacetylated chitosan can form hydrogen bonds with a large number of water molecules, thereby attracting and retaining a large amount of water. The formation of this hydrogen bond not only increases the moisturizing performance of the gel composition, but also keeps the skin surface moist and prevents the loss of water.

[0075] By observing the test data results of the gel composition stability test in Table 2, it can be found that compared with Examples 1-6 and Comparative Examples 1-2, the stability data of the gel composition for beauty and skin care prepared in Examples 1-6 is better. The reason for the difference in these test results may be that the quaternary ammonium grafting modification of cyclodextrin is achieved by introducing components such as hydroxypropyl deacetylated chitosan. This modification not only improves the solubility and biocompatibility of cyclodextrin, but also enhances its interaction with other components in the gel composition, thereby contributing to the stability of the gel.

Claims

1. A gel composition, characterized in that: The invention comprises the following components in parts by weight: 10-50 parts of water, 5-10 parts of 1,3-butylene glycol, 3-10 parts of sorbitan olivate, 4-8 parts of allantoin, 1-5 parts of carbomer, 5-15 parts of squalane and 3-15 parts of modified cyclodextrin; The preparation method of the modified cyclodextrin comprises the following steps, calculated in parts by weight: S1, dissolving 2-10 parts of methyl beta-cyclodextrin in 80-100 parts of sodium hydroxide solution, leaving for 24-30 hours, adding 1-5 parts of p-toluenesulfonyl chloride, stirring at 0-5°C for 2-4 hours, filtering the mixture, mixing the filtrate with 2-8 parts of grafting agent and 30-60 mL of N,N-dimethylformamide in 40-80 mL of 1-3 wt% acetic acid solution, stirring at 80-100°C at 200-300 rpm for 20-30 hours, then cooling to 45-60°C, adding 5-12 parts of glycidyl trimethylammonium chloride, stirring at 50-70°C at 200-300 rpm for 4-7 hours, dialyzing for 3-7 hours, cutting off the molecular weight of 3000-3500 Da, and freeze-drying to obtain quaternary ammonium cyclodextrin grafted chitosan; S2, adding 2-10 parts of a modifier and 1-3 parts of a synergist to the quaternized cyclodextrin grafted chitosan prepared in S1, and then stirring at 200-300 rpm for 30-60 min at room temperature to obtain modified cyclodextrin; The grafting agent is any one of 6'-C-aminomethyl-1,3,2',3''-tetra(N-tert-butyloxycarbonyl)-3',4'-dideoxykanamycin C and hydroxypropyl chitosan; The modifier is any one of sodium hyaluronate, sodium citrate, sodium oleate, and sodium salt of D-glucuronic acid; The enhancer is retinol.

2. The gel composition according to claim 1, characterized in that The modifier is D-glucuronic acid sodium salt.

3. The gel composition according to claim 1, characterized in that The mass fraction of the sodium hydroxide solution is 8-12wt%.

4. The method for preparing the gel composition according to any one of claims 1 to 3, characterized in that: The method comprises the following steps, in parts by weight: Step 1, 10-50 parts of water, 5-10 parts of 1,3-butylene glycol, 3-10 parts of sorbitan olivate, 4-8 parts of allantoin, 1-5 parts of carbomer, and 5-15 parts of squalane are mixed at 200-300 rpm for 20-30 minutes to obtain an emulsion; Step 2: Add 3-15 parts of modified cyclodextrin to the emulsion prepared in step 1 and stir at 200-300 rpm to form a transparent gel, thereby obtaining a beauty and skin care gel composition.

5. Use of the gel composition according to any one of claims 1 to 3 in beauty and skin care.

Images