A composition with whitening effect and its application in cosmetics

Abstract

The present invention relates to a composition with whitening efficacy and its application in cosmetics, wherein the composition comprises a whitening component, an antioxidant component, an anti-inflammatory component and a barrier repair component, wherein the whitening component comprises potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine, the antioxidant component comprises lipoic acid and carnosine; the anti-inflammatory component comprises dipotassium glycyrrhizinate and perilla leaf extract; and the barrier repair component comprises biosaccharide gum-1. The present invention creatively finds that the whitening component, the antioxidant component, the anti-inflammatory component and the barrier repair component play a synergistic role in the skin whitening function. Compared with a single whitening approach, the whitening composition provided by the present invention utilizes different action mechanisms to synergistically enhance the effect, solves the skin whitening problem in a multi-targeted manner, and meets the functional needs of consumers.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to a composition with whitening effect and application thereof in cosmetics. Background Art

[0002] Currently, the whitening products on the market lack a multi-dimensional combination, and are mostly single targeted single-acting substances. Therefore, it is of great significance to develop efficient multi-mechanism compositions based on consumer needs and targeted mechanisms so that they can achieve the best results and meet consumer needs. Summary of the invention

[0003] In view of the deficiencies of the prior art, the object of the present invention is to provide a composition with whitening effect and its application in cosmetics.

[0004] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0005] In the first aspect, the present invention provides a composition with whitening effect, the composition comprising a whitening component, an antioxidant component, an anti-inflammatory component and a barrier repair component; the whitening component comprises potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine; the antioxidant component comprises lipoic acid and carnosine; the anti-inflammatory component comprises dipotassium glycyrrhizate and perilla leaf extract; the barrier repair component comprises biosaccharide gum-1.

[0006] The present invention creatively combines whitening components, antioxidant components, anti-inflammatory components and barrier repair components, and finds that they can play a synergistic role in skin whitening efficacy. Compared with a single whitening approach, the whitening composition provided by the present invention utilizes different mechanisms of action to synergistically enhance efficacy, solves the skin whitening problem in a multi-targeted manner, and meets the functional needs of consumers.

[0007] At the same time, the present invention also creatively discovered that when the four ingredients of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine are used as whitening components, the skin whitening effect of the composition is significantly improved, and the four ingredients have a certain synergistic effect on the whitening effect.

[0008] Preferably, the whitening component comprises, by weight, 0.01-0.2 parts of potassium 4-methoxysalicylate, 1-5 parts of ascorbyl glucoside, 1-5 parts of tranexamic acid and 1-5 parts of acetylglucosamine.

[0009] Furthermore, when the above four components are combined in a specific mass ratio, the composition has a more significant effect in skin whitening.

[0010] The weight proportions of the potassium 4-methoxysalicylate can be 0.01 parts, 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, etc.

[0011] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0012] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0013] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0014] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0015] Preferably, the antioxidant component comprises 0.01-0.2 parts of lipoic acid and 0.5-2 parts of carnosine in parts by weight.

[0016] The present invention creatively finds that when lipoic acid and carnosine are selected as antioxidant components, their combination with whitening components, anti-inflammatory components and barrier repair components has a more significant synergistic effect on skin whitening. When 0.01-0.2 parts of lipoic acid and 0.5-2 parts of carnosine are used, the whitening effect is further enhanced.

[0017] The weight proportion of the lipoic acid can be 0.01 part, 0.02 part, 0.04 part, 0.06 part, 0.08 part, 0.1 part, 0.12 part, 0.14 part, 0.16 part, 0.18 part, 0.2 part, etc.

[0018] The weight proportions of the carnosine can be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.

[0019] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0020] Preferably, the anti-inflammatory component comprises 0.01-1 parts of dipotassium glycyrrhizinate and 1-5 parts of perilla leaf extract by weight.

[0021] The present invention creatively discovered that when dipotassium glycyrrhizinate and perilla leaf extract are selected as anti-inflammatory components, the synergistic effect of their combination with whitening components, antioxidant components and barrier repair components on skin whitening is more significant. When 0.01-1 parts of dipotassium glycyrrhizinate and 1-5 parts of perilla leaf extract are used, the whitening effect is further enhanced.

[0022] The weight proportions of the dipotassium glycyrrhizinate can be 0.01 parts, 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, etc.

[0023] The weight proportions of the perilla leaf extract can be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.

[0024] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0025] Preferably, the barrier repair component includes 0.01-0.2 parts of biosaccharide gum-1 by weight, for example, 0.01 parts, 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, etc. Other specific point values ​​within this numerical range can be selected and will not be repeated here.

[0026] The present invention creatively discovered that when biosaccharide gum-1 is selected as the barrier repair component, its combination with the whitening component, the antioxidant component and the anti-inflammatory component has a more significant synergistic effect on skin whitening. When 0.01-0.2 parts of biosaccharide gum-1 are used, the whitening effect is further enhanced.

[0027] Preferably, the composition consists of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid, acetylglucosamine, lipoic acid, carnosine, dipotassium glycyrrhizate, perilla leaf extract and biosaccharide gum-1.

[0028] Preferably, the composition with whitening effect comprises, by weight, 0.01-0.2 parts of potassium 4-methoxysalicylate, 1-5 parts of ascorbyl glucoside, 1-5 parts of tranexamic acid, 1-5 parts of acetylglucosamine, 0.01-0.2 parts of lipoic acid, 0.5-2 parts of carnosine, 0.01-1 parts of dipotassium glycyrrhizinate, 1-5 parts of perilla leaf extract and 0.01-0.2 parts of biosaccharide gum-1.

[0029] The above weight proportions are all calculated based on the actual effective ingredients potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid, acetylglucosamine, lipoic acid, carnosine, dipotassium glycyrrhizate, perilla leaf extract and biosaccharide gum-1 contained in the commercially available raw materials. The commercially available raw materials may also selectively contain any one or a combination of at least two of solvents, fillers, diluents, stabilizers, pH regulators, antibacterial agents, antioxidants or impurities within the permitted range.

[0030] The weight proportions of the potassium 4-methoxysalicylate can be 0.01 parts, 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, etc.

[0031] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0032] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0033] The weight proportions of the ascorbyl glucoside can be 1 part, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.

[0034] The weight proportion of the lipoic acid can be 0.01 part, 0.02 part, 0.04 part, 0.06 part, 0.08 part, 0.1 part, 0.12 part, 0.14 part, 0.16 part, 0.18 part, 0.2 part, etc.

[0035] The weight proportions of the carnosine can be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.

[0036] The weight proportions of the dipotassium glycyrrhizinate can be 0.01 parts, 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, etc.

[0037] The weight proportions of the perilla leaf extract can be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.

[0038] The weight proportion of the biosaccharide gum-1 can be 0.01 part, 0.02 part, 0.04 part, 0.06 part, 0.08 part, 0.1 part, 0.12 part, 0.14 part, 0.16 part, 0.18 part, 0.2 part, etc.

[0039] Any other specific point value within the above numerical range can be selected, and will not be described in detail here.

[0040] In a second aspect, the present invention provides a use of the composition with whitening effect according to the first aspect in the preparation of cosmetics.

[0041] Preferably, the cosmetics include facial cream, essence, lotion, facial mask, toner or facial cleanser.

[0042] Preferably, the mass percentage of the composition with whitening effect in the cosmetics is 5-30%, for example 5%, 6%, 8%, 10%, 15%, 20%, 25%, 30%, etc. Other specific point values ​​within this numerical range can be selected and will not be described here one by one.

[0043] Compared with the prior art, the present invention has the following beneficial effects:

[0044] The present invention creatively finds that whitening components, antioxidant components, anti-inflammatory components and barrier repair components play a synergistic role in skin whitening function. At the same time, the present invention also creatively finds that when the four ingredients of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine are used as whitening components, they play a synergistic role in skin whitening function. Compared with a single whitening approach, the whitening composition proposed by the present invention uses different mechanisms of action to synergistically enhance the effect, solve the skin whitening problem in a multi-targeted manner, and meet the functional needs of consumers. DETAILED DESCRIPTION

[0045] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0046] The weight proportions of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid, acetylglucosamine, lipoic acid, carnosine, dipotassium glycyrrhizinate, perilla leaf extract and biosaccharide gum-1 mentioned below are all calculated based on the actual content of effective ingredients contained in the commercially available raw materials. The commercially available raw materials may also selectively contain any one or a combination of at least two of solvents, fillers, diluents, stabilizers, pH adjusters, antibacterial agents, antioxidants or impurities within the permitted range.

[0047] The perilla leaf extracts involved in the following examples, comparative examples, application examples, and comparative application examples were purchased from Technoble Co., Ltd., model PERIILAN·F;

[0048] Biosaccharide Gel-1 was purchased from Xianting (International) Co., Ltd., model number FUCOGEL 1.5P;

[0049] Hydrolyzed sodium hyaluronate was purchased from Bloomage Biotech Co., Ltd., model number Nano HA;

[0050] Cyclopentasiloxane was purchased from Shin-Etsu, Japan, model number KF-995;

[0051] Ammonium acryloyldimethyltaurate / VP copolymer was purchased from Clariant Chemical Technology (Shanghai) Co., Ltd., model Aristoflex AVC;

[0052] Potassium lauryl phosphate was purchased from Dandong Ankang Fine Chemical Co., Ltd., and the model was HR-S1 emulsifier.

[0053] Example 1

[0054] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in parts by weight: 0.1 parts of potassium 4-methoxysalicylate, 3 parts of ascorbyl glucoside, 3 parts of tranexamic acid, 3 parts of acetylglucosamine, 0.1 parts of lipoic acid, 1 part of carnosine, 0.05 parts of dipotassium glycyrrhizinate, 3 parts of perilla leaf extract and 0.1 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0055] Example 2

[0056] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in parts by weight: 0.2 parts of potassium 4-methoxysalicylate, 5 parts of ascorbyl glucoside, 5 parts of tranexamic acid, 5 parts of acetylglucosamine, 0.2 parts of lipoic acid, 2 parts of carnosine, 1 part of dipotassium glycyrrhizinate, 5 parts of perilla leaf extract and 0.2 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0057] Example 3

[0058] The present embodiment provides a composition with whitening effect, which comprises the following effective ingredients in parts by weight: 0.01 parts of potassium 4-methoxysalicylate, 1 part of ascorbyl glucoside, 1 part of tranexamic acid, 1 part of acetylglucosamine, 0.01 parts of lipoic acid, 0.5 parts of carnosine, 0.01 parts of dipotassium glycyrrhizinate, 1 part of perilla leaf extract and 0.01 parts of biosaccharide gum-1, and the above ingredients are physically mixed and uniformly mixed.

[0059] Example 4

[0060] The present embodiment provides a composition with whitening effect, which comprises the following effective ingredients in parts by weight: 3 parts of potassium 4-methoxysalicylate, 0.1 parts of ascorbyl glucoside, 3 parts of tranexamic acid, 3 parts of acetylglucosamine, 1 part of lipoic acid, 0.1 parts of carnosine, 3 parts of dipotassium glycyrrhizinate, 0.05 parts of perilla leaf extract and 0.1 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0061] Comparative Example 1

[0062] This comparative example provides a composition with whitening effect, which includes the following active ingredients in parts by weight: 0.1 parts of potassium 4-methoxysalicylate, 3 parts of ascorbyl glucoside, 3 parts of tranexamic acid, 3 parts of acetylglucosamine, 0.05 parts of dipotassium glycyrrhizinate, 3 parts of perilla leaf extract and 0.1 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0063] Comparative Example 2

[0064] This comparative example provides a composition with whitening effect, which includes the following effective ingredients in parts by weight: 0.1 parts of potassium 4-methoxysalicylate, 3 parts of ascorbyl glucoside, 3 parts of tranexamic acid, 3 parts of acetylglucosamine, 0.1 parts of lipoic acid, 1 part of carnosine and 0.1 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0065] Comparative Example 3

[0066] This comparative example provides a composition with whitening effect, which includes the following effective ingredients in parts by weight: 0.1 parts of potassium 4-methoxysalicylate, 3 parts of ascorbyl glucoside, 3 parts of tranexamic acid, 3 parts of acetylglucosamine, 0.1 parts of lipoic acid, 1 part of carnosine, 0.05 parts of dipotassium glycyrrhizinate and 3 parts of perilla leaf extract, and the above ingredients are physically mixed evenly.

[0067] Comparative Example 4

[0068] This comparative example provides a composition with whitening effect, which includes the following effective ingredients in parts by weight: 0.1 parts of lipoic acid, 1 part of carnosine, 0.05 parts of dipotassium glycyrrhizinate, 3 parts of perilla leaf extract and 0.1 parts of biosaccharide gum-1, and the above ingredients are physically mixed evenly.

[0069] Comparative Example 5

[0070] This comparative example provides a composition with whitening effect, which differs from Example 1 only in that potassium 4-methoxysalicylate is not added, and its reduced weight portion is distributed to ascorbyl glucoside, tranexamic acid and acetylglucosamine according to the proportion in Example 1, and other conditions remain unchanged.

[0071] Comparative Example 6

[0072] This comparative example provides a composition with whitening effect, which differs from Example 1 only in that ascorbyl glucoside is not added, and the reduced weight portion thereof is distributed to potassium 4-methoxysalicylate, tranexamic acid and acetylglucosamine according to the proportion in Example 1, and other conditions remain unchanged.

[0073] Comparative Example 7

[0074] This comparative example provides a composition with whitening effect, which differs from Example 1 only in that tranexamic acid is not added, and its reduced weight portion is distributed to potassium 4-methoxysalicylate, ascorbyl glucoside and acetylglucosamine according to the proportion in Example 1, and other conditions remain unchanged.

[0075] Comparative Example 8

[0076] This comparative example provides a composition with whitening effect, which differs from Example 1 only in that acetylglucosamine is not added, and its reduced weight portion is distributed to potassium 4-methoxysalicylate, ascorbyl glucoside and tranexamic acid according to the proportion in Example 1, and other conditions remain unchanged.

[0077] Comparative Example 9

[0078] This comparative example provides a composition with whitening effect, which is different from Example 1 only in that ascorbyl glucoside is replaced by niacinamide in an equal amount, and other conditions remain unchanged.

[0079] Application Example 1

[0080] This application example provides an essence with whitening effect, which contains 10% by weight of the composition of Example 1, and the formula table is as follows:

[0081]

[0082]

[0083] The preparation method is as follows:

[0084] (1) Add the raw materials of phase A into a clean emulsifying pot, stir and heat to 85°C, keep warm for 20 minutes, and turn on the cooling water to cool down;

[0085] (2) Pre-mix the raw materials of phase B and phase D respectively, stir them evenly and set aside;

[0086] (3) When the temperature in the emulsifier drops below 45°C, add the phase C raw material and the pre-treated phase B and phase D raw materials into the emulsifier and stir to disperse them evenly;

[0087] (4) Continue cooling down to 38°C.

[0088] Application Example 2-4

[0089] This application example provides three essences with whitening effects, each of which contains 10% by weight of the composition of Examples 2-4. The difference between the formula table and Application Example 1 is that the composition of Example 1 is replaced by the composition of Examples 2-4. The preparation method refers to Application Example 1.

[0090] Comparative Application Examples 1-9

[0091] This comparative application example provides nine essences with whitening effects, each of which contains 10% by weight of the composition of comparative examples 1 to 8. The difference between the formula table and application example 1 is that the composition of example 1 is replaced by the composition of comparative examples 1 to 8. The preparation method refers to application example 1.

[0092] Test Example 1

[0093] Whitening efficacy test:

[0094] Wild-type AB strain zebrafish 6 hours after fertilization were randomly selected in a 6-well plate, with 15 in each well, and the whitening essence prepared in Application Examples 1-4 and Comparative Application Examples 1-8 was administered in water as a sample group. A normal control group (no whitening essence) was set up at the same time, with a capacity of 3 mL in each well, and the cells were incubated in the dark at 28°C for 45 hours. Ten zebrafish were randomly selected from each experimental group and placed under a dissecting microscope. Advanced image processing software was used to analyze and collect data, and the melanin signal intensity (S) of the zebrafish head was analyzed. The whitening efficacy of the sample was calculated according to the formula to determine whether it had whitening efficacy. The results are shown in Table 1, wherein p<0.05 in the statistical analysis.

[0095] Whitening effect (%) = (S 正常对照组 -S 样品组 ) / S 正常对照组 ×100%.

[0096] Table 1

[0097] Group Whitening effect (%) Application Example 1 86.03 Application Example 2 83.72 Application Example 3 70.21 Application Example 4 65.89 Comparative application example 1 62.56 Comparative Application Example 2 55.87 Comparative Application Example 3 57.33 Comparative Application Example 4 52.61 Comparative Application Example 5 61.02 Comparative Application Example 6 59.89 Comparative Application Example 7 61.55 Comparative Application Example 8 64.72 Comparative Application Example 9 58.83

[0098] From the data in Table 1, it can be seen that: by comparing Application Example 1 with Application Example 4, it can be found that when the components in the composition with whitening effect are combined in a specific mass ratio, it has a more significant effect on skin whitening; by comparing Application Example 1 with Comparative Application Examples 1-4, it can be found that the whitening component, antioxidant component, anti-inflammatory component and barrier repair component achieve synergistic enhancement between different action mechanisms in skin whitening; by comparing Application Example 1 with Comparative Application Examples 5-9, it can be found that the four ingredients of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine in the whitening component achieve a synergistic effect on skin whitening.

[0099] Test Example 2

[0100] Soothing effect test:

[0101] Transgenic neutrophil green fluorescent zebrafish 2 days after fertilization were randomly selected in a 6-well plate, 15 per well, and sodium dodecyl sulfate was given in water to establish a zebrafish skin inflammation model. The whitening essence prepared in Application Examples 1-3 was given in water as a sample group, and a normal control group and a model control group were set up at the same time. The normal control group was a zebrafish that was not given sodium dodecyl sulfate and whitening essence, and the model control group was a zebrafish skin inflammation model group established with sodium dodecyl sulfate, without whitening essence, and the capacity of each well was 3mL. Incubated in the dark at 28°C for 18h, 10 zebrafish were randomly selected from each experimental group and placed under a fluorescence microscope for photography, and data were analyzed and collected using advanced image processing software, the number of neutrophils in zebrafish skin (N) was analyzed, and the soothing effect of the sample was calculated according to the formula to determine whether it had a soothing effect. The results are shown in Table 2, where p<0.05 in the statistical analysis.

[0102] Soothing effect (%) = (S 模型对照组 -S 样品组 ) / (S 模型对照组 -S 正常对照组 )×100%.

[0103] Table 2

[0104] Group Soothing effect (%) Application Example 1 80.99 Application Example 2 75.31 Application Example 3 72.57

[0105] From the data in Table 2, it can be seen that the essence with whitening effect provided by the present invention also has significant anti-inflammatory and soothing effects.

[0106] Test Example 3

[0107] Darkening effect test:

[0108] 130 volunteers aged 21 to 57 were selected and randomly divided into 13 groups, with 10 in each group. The faces of the subjects were selected as the test sites. After cleaning their faces, the subjects sat quietly for 30 minutes in a constant environment with a temperature of 21±1°C and a relative humidity of 50±10% RH. The staff collected baseline data on the test sites before use, including instrument testing (skin test data acquisition software MPA CTplus, VISIA-CR facial image analyzer) and standard image shooting. The staff distributed the test products and provided guidance to the subjects according to the instructions for use to ensure that the subjects used the products correctly and continuously for 2 weeks. The same evaluation and test were performed again 1 week and 2 weeks after the products were used. The results after 1 week of use are shown in Table 3, and the results after 2 weeks of use are shown in Table 4. The higher the ITA° value, the lighter the skin color, the smaller the MI value, the less skin melanin, and the smaller the mean optical density of the spots, the lighter the skin spots.

[0109] Difference rate = (nth week after sample use - before use) / before use × 100%.

[0110] Table 3

[0111]

[0112]

[0113] Table 4

[0114] Group ITA° value difference rate MI value difference rate The difference rate of mean optical density of spots Application Example 1 23.05 -18.37 -5.47 Application Example 2 22.41 -17.52 -5.29 Application Example 3 20.18 -17.06 -4.88 Application Example 4 18.75 -15.24 -4.29 Comparative application example 1 17.25 -14.92 -3.33 Comparative Application Example 2 16.89 -14.25 -3.56 Comparative Application Example 3 17.33 -13.31 -2.01 Comparative Application Example 4 15.68 -7.95 -4.21 Comparative Application Example 5 17.84 -16.00 -3.87 Comparative Application Example 6 15.96 -12.09 -2.74 Comparative Application Example 7 14.76 -14.76 -2.71 Comparative Application Example 8 15.35 -14.22 -4.02 Comparative Application Example 9 16.81 -12.17 -3.55

[0115] From the data in Tables 3 and 4, it can be seen that: by comparing Application Example 1 with Application Example 4, it can be found that when the components in the composition with whitening effect are combined in a specific mass ratio, it has a more significant effect on skin whitening; by comparing Application Example 1 with Comparative Application Examples 1-4, it can be found that the whitening component, antioxidant component, anti-inflammatory component and barrier repair component achieve synergistic enhancement between different action mechanisms in skin whitening; by comparing Application Example 1 with Comparative Application Examples 5-9, it can be found that the four ingredients of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid and acetylglucosamine in the whitening component achieve a synergistic effect on skin whitening.

[0116] Test Example 4

[0117] Skin safety test:

[0118] 40 volunteers aged 21 to 57 were selected and randomly divided into 4 groups, 10 in each group, 5 females and 5 males in each group, and the essences prepared in application examples 1-4 were tried in each group, and about 0.020mL-0.025mL was placed in the small chamber of the spot tester, and no treatment was performed on the control well. The spot tester with the test substance was applied to the back of the subject with a low-allergenic tape, and the test substance was removed after 24 hours. The test substance was removed after 24 hours after the test substance spot tester was removed, and the skin reaction was observed at 0.5, 24, and 48 hours after removal, and the results were recorded according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 edition).

[0119] Table 5

[0120]

[0121] The results showed that application examples 1-4 of the present invention all had negative reactions, indicating that the essence involved in the present invention is safe and mild, and will not cause adverse reactions such as skin irritation and sensitization.

[0122] The applicant declares that the present invention illustrates the technical solution of the present invention through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0123] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0124] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A composition with whitening effect, characterized in that: The composition includes a whitening component, an antioxidant component, an anti-inflammatory component and a barrier repair component; The whitening component includes, by weight, 0.01-0.2 parts of potassium 4-methoxysalicylate, 1-5 parts of ascorbyl glucoside, 1-5 parts of tranexamic acid and 1-5 parts of acetylglucosamine; The antioxidant components include lipoic acid and carnosine; The anti-inflammatory component includes dipotassium glycyrrhizinate and perilla leaf extract; The barrier repair component includes Biosaccharide Gum-1.

2. The composition with whitening effect according to claim 1, characterized in that: The antioxidant component comprises 0.01-0.2 parts of lipoic acid and 0.5-2 parts of carnosine in parts by weight.

3. The composition with whitening effect according to claim 1, characterized in that: The anti-inflammatory component comprises 0.01-1 parts of dipotassium glycyrrhizinate and 1-5 parts of perilla leaf extract by weight.

4. The composition with whitening effect according to claim 1, characterized in that: The barrier repair component includes 0.01-0.2 parts of biosaccharide gum-1 by weight.

5. The composition with whitening effect according to claim 1, characterized in that: The composition consists of potassium 4-methoxysalicylate, ascorbyl glucoside, tranexamic acid, acetylglucosamine, lipoic acid, carnosine, dipotassium glycyrrhizinate, perilla leaf extract and biosaccharide gum-1.

6. The composition with whitening effect according to claim 1, characterized in that: The composition with whitening effect comprises, by weight, 0.01-0.2 parts of potassium 4-methoxysalicylate, 1-5 parts of ascorbyl glucoside, 1-5 parts of tranexamic acid, 1-5 parts of acetylglucosamine, 0.01-0.2 parts of lipoic acid, 0.5-2 parts of carnosine, 0.01-1 parts of dipotassium glycyrrhizinate, 1-5 parts of perilla leaf extract and 0.01-0.2 parts of biosaccharide gum-1.

7. Use of the composition with whitening effect according to any one of claims 1 to 6 in the preparation of cosmetics.

8. The use according to claim 7, characterized in that: The cosmetics include facial cream, essence, lotion, facial mask, toner or facial cleanser.

9. The use according to claim 7 or 8, characterized in that: The mass percentage of the composition with whitening effect in cosmetics is 5-30%.

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