A hair loss prevention and hair growth composition, a preparation method thereof, and a hair care cosmetic containing the hair loss prevention and hair growth composition

Abstract

The invention discloses a hair loss prevention and hair growth composition, a preparation method thereof, and a hair care cosmetic containing the hair loss prevention and hair growth composition, which is composed of the following components: 1-2 parts of ginger root extract; 1-2 parts of Polygonum multiflorum extract; 2.58-8.3 parts of skin auxiliary conditioner; 0.56-2.1 parts of hair auxiliary conditioner; 0.1-2 parts of preservative; 5-15 parts of moisturizer; 70-85 parts of water. The above composition can effectively improve the hair microenvironment, inhibit sebum secretion, and prolong the hair survival cycle through the cooperation of the skin auxiliary conditioner and the ginger root extract. While comprehensively preventing hair loss, the hair auxiliary conditioner and the Polygonum multiflorum extract are used to regulate the blood supply of the key parts of the hair follicle cycle growth, enhance the vitality of the hair, and strengthen the hair roots, thereby achieving a comprehensive solution to various problems such as seborrheic alopecia, neurotic alopecia, diffuse alopecia, and nutritional alopecia.

Description

Technical Field

[0001] The invention relates to the technical field of hair care products, in particular to a hair loss prevention and hair growth composition and a preparation method thereof, and hair care cosmetics containing the hair loss prevention and hair growth composition. Background Art

[0002] In modern life, due to the increasing pressure of life and work and the impact of environmental pollution, the incidence of premature hair loss and graying hair is increasing year by year. Hair loss is a common and frequently-occurring disease. It is one of the external manifestations of human internal diseases and human aging. It has long been a threat to people's physical and mental health. There are more than a dozen types of hair loss, such as seborrheic alopecia, alopecia areata, alopecia totalis, alopecia universalis, postpartum alopecia, and alopecia caused by drugs and certain diseases. Among them, seborrheic alopecia is the most common, accounting for more than 95% of patients.

[0003] Hair loss is divided into temporary hair loss and permanent hair loss. Temporary hair loss is caused by short-term damage to hair follicles, while permanent hair loss is caused by damage to hair follicles. Hair grows in hair follicles, and the hair follicle tissue is divided into hair papilla, hair bulb, and sebaceous gland. The hair papilla grows capillaries, nerve endings, and connective tissue, which provide nutrients for the growth of hair and play an important role in the growth of hair. Studies have shown that the cause of hair loss is excessive sebum secretion. Some components in the skin, such as oleic acid, linoleic acid, and squalene, are toxic to hair follicles when in excess, causing hair poisoning, withering, and shedding.

[0004] At present, most hair growth products use a combination of ginger and Polygonum multiflorum. Although ginger has anti-inflammatory and antibacterial effects, can reduce scalp inflammation and scalp infection, and promote blood circulation to provide more nutrition to hair follicles, thereby helping hair growth, Polygonum multiflorum has the effects of improving the nutritional supply of hair follicles and stimulating hair growth, but studies have shown that the irritation of certain ingredients in ginger may cause scalp inflammation or contact dermatitis, which may inhibit hair growth and affect its hair growth effect. Given the complex structure of hair follicle tissue, relying solely on ginger and Polygonum multiflorum to treat hair loss is often ineffective, and if used improperly, it is easy to cause damage to the head skin, which will eventually lead to more severe hair loss. Summary of the invention

[0005] In order to overcome the deficiencies of the prior art, one of the objectives of the present invention is to provide a hair loss prevention and hair growth composition to solve the above-mentioned traditional technical problems.

[0006] The second object of the present invention is to provide a method for preparing the above-mentioned hair loss prevention and hair growth composition.

[0007] The third object of the present invention is to provide a hair care cosmetic containing the hair loss preventing and hair growth composition.

[0008] One of the purposes of the present invention is achieved by the following technical solution:

[0009] A hair loss prevention and hair growth composition, comprising the following components in parts by weight:

[0010] 1-2 parts of ginger root extract; 1-2 parts of Polygonum multiflorum extract; 2.58-8.3 parts of skin conditioning agent; 0.56-2.1 parts of hair conditioning agent; 0.1-2 parts of preservative; 5-15 parts of moisturizer; 70-85 parts of water;

[0011] The skin auxiliary conditioning agent is composed of Gleditsia sinensis seed extract, Lithospermum officinale root extract, Artemisia argyi leaf extract, Clove flower extract, Tea leaf extract, Coptis chinensis root extract, Evodia rutaecarpa fruit extract, Mulberry leaf extract, Phellodendron amurense bark extract, Capsicum fruit extract, Sapindus mukorossi fruit extract, Cyperus rotundus root extract and Paeonia lactiflora root extract in a mass ratio of (0.5-1.5):(0.5-1.5):(0.5-1.5):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1);

[0012] The hair auxiliary conditioner is composed of safflower flower extract, salvia miltiorrhiza root extract, Ligustrum lucidum fruit extract, Channa intestine extract, Pueraria root extract, Cuscuta australis extract and Eucommia bark extract in a mass ratio of (0.5-1.5):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1).

[0013] The applicant unexpectedly discovered in the study that by adding effective auxiliary ingredients such as skin auxiliary conditioners and hair auxiliary conditioners to the components of ginger root extract and Polygonum multiflorum extract, the hair is rich in active ingredients such as ginsenosides, ferulic acid, polysaccharides, alkaloids, flavonoids, volatile oils, etc., wherein, by the combination of skin auxiliary conditioners and ginger root extracts, the hair microenvironment can be effectively improved, sebum secretion can be inhibited, and the survival cycle of hair can be prolonged. On the other hand, the irritation of certain components in ginger can be avoided, thereby achieving an effective effect of stopping hair loss. While stopping hair loss comprehensively, the blood supply to the key parts of the hair follicle cycle growth is regulated by the combination of hair auxiliary conditioners and Polygonum multiflorum extracts, the vitality of hair is enhanced, and the hair roots are strengthened, thereby achieving a comprehensive solution to various problems such as seborrheic alopecia, neurotic alopecia, diffuse alopecia, nutritional alopecia, etc. On the basis of the above effective ingredients, preservatives, moisturizers and water are combined to make the composition more fully compounded to improve its efficacy.

[0014] Among them, ginger root extract has anti-inflammatory and antibacterial effects, which can reduce scalp inflammation and scalp infection, and provide more nutrients to hair follicles by promoting blood circulation, thereby helping hair growth.

[0015] Polygonum multiflorum extract is also a hair auxiliary conditioning agent that can upregulate the expression of anti-apoptosis genes in human hair papilla cells, downregulate the expression of apoptosis-related genes, and reduce the production of androgen receptors, thereby delaying hair follicle degeneration, and stimulating hair growth by promoting blood circulation and improving the nutrient supply of hair follicles.

[0016] The skin auxiliary conditioner is compounded with 13 components including Gleditsia sinensis seed extract, Lithospermum officinale root extract, Artemisia argyi leaf extract, Clove flower extract, Tea leaf extract, Coptis chinensis root extract, Evodia rutaecarpa fruit extract, Mulberry leaf extract, Phellodendron amurense bark extract, Capsicum fruit extract, Sapindus mukorossi fruit extract, Cyperus rotundus root extract, Paeonia lactiflora root extract, etc. Each component plays a different role. After compounding, it can effectively improve the hair microenvironment, inhibit sebum secretion, prolong the survival cycle of hair, and can comprehensively solve various hair loss problems. The effects of each component on the head skin are as follows:

[0017] (1) Gleditsia sinensis seed extract: It has the effects of cleansing the scalp, improving the scalp environment, removing dandruff, improving scalp itching, and improving dry scalp.

[0018] (2) Lithospermum officinale extract: It can moisturize and replenish moisture to the skin. It can also reduce swelling, itching and relieve dry skin conditions. It can effectively soothe the skin, thereby promoting cell renewal and repairing damaged tissues.

[0019] (3) Mugwort extract: It can treat symptoms such as dermatitis, rashes, itching, blood stasis and dry skin. It is also rich in mugwort essential oil, which can balance the water and oil balance of the skin and improve oily skin problems.

[0020] (4) Lilac flower extract: It has the effects of reducing swelling and inflammation, treating skin ulcers and wound inflammation, and improving rough skin. It also has an inhibitory effect on 5α-reductase, which helps improve the scalp environment and provide better conditions for hair growth.

[0021] (5) Tea extract: It contains tea polyphenols, which can enhance the water-locking ability of the scalp's stratum corneum, effectively prevent water loss in scalp cells, and help regulate the oil secretion of the scalp, reducing oil clogging of hair follicles, thereby promoting hair growth.

[0022] (6) Coptis chinensis root extract: It can inhibit the growth of many bacteria and fungi, reduce oil secretion, and has antioxidant properties, which helps protect the scalp and hair follicles from damage by free radicals and promotes hair health.

[0023] (7) Evodia rutaecarpa fruit extract: It has an inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium tuberculosis, etc., and combined with the antibacterial effect of other ingredients, it provides better conditions for hair growth.

[0024] (8) Mulberry leaf extract: Contains flavonoids, phenols and other substances, which have a certain antibacterial effect and can reduce the number of bacteria on the scalp, thereby alleviating itching symptoms.

[0025] (9) Phellodendron chinense bark extract: It can regulate the microecological environment of the scalp, reduce scalp inflammation and infection, thereby effectively inhibiting bacteria and maintaining the balance of scalp flora. It has the dual effects of stimulating hair follicle growth and promoting hair growth.

[0026] (10) Capsicum fruit extract: Its active ingredient is capsaicin, which has the effect of regulating skin oil secretion, etc., especially for people with strong oil secretion, it can effectively improve the phenomenon of greasy skin. Due to its high irritation to the skin, it is generally necessary to limit its dosage to 0.01%-0.1% of the total amount, preferably 0.05%-0.1%.

[0027] (11) Soapberry fruit extract: It has good degreasing and scalp cleaning effects. It can effectively remove dirt, oil and dandruff on the scalp and keep the scalp clean.

[0028] (12) Cyperus rotundus root extract: It has the effect of relieving itching and detoxification, can reduce oil secretion, and can prevent scalp itching, pimples, etc.

[0029] (13) Peony root extract: Contains paeoniflorin, which has strong moisturizing and antibacterial properties, can inhibit scalp inflammatory reactions, and can promote scalp repair and protection.

[0030] The hair auxiliary conditioner is made up of 7 components, including safflower flower extract, salvia miltiorrhiza root extract, Ligustrum lucidum fruit extract, Channa intestine extract, Pueraria root extract, Cuscuta seed extract, and Eucommia bark extract. Each component plays a different role and provides different active ingredients for hair growth. After compounding, it can regulate the blood supply to the key parts of the hair follicle cycle growth, enhance the vitality of hair, and strengthen the hair roots. The effects of each component on hair follicles and hair are as follows:

[0031] (1) Carthamus tinctorius flower extract: It is rich in a variety of active ingredients, such as flavonoids and oleic acid, which can promote blood circulation in the scalp, increase the nutritional supply of hair, and promote the proliferation of dermal papilla cells and keratinocytes (HaCaT). It can also significantly stimulate the expression of hair growth-promoting genes, such as vascular endothelial growth factor and keratinocyte growth factor, thereby promoting hair growth and reducing hair loss.

[0032] (2) Salvia miltiorrhiza root extract: It contains main ingredients such as phenanthrenequinone derivatives, danshensu and protocatechuic aldehyde, which can promote the proliferation of collagen and help enhance the strength and elasticity of hair.

[0033] (3) Ligustrum lucidum fruit extract: Contains oleanolic acid, which can improve the microcirculation around the hair follicles, especially the blood supply to the dermal papilla, a key part in regulating the growth cycle of hair follicles.

[0034] (4) Channa Intestine Extract: Rich in amino acids, vitamins and some minerals, these ingredients can help nourish hair, making it softer and healthier.

[0035] (5) Pueraria root extract: rich in vitamins and proteins, it has special effects in helping damaged hair recover.

[0036] (6) Cuscuta extract: rich in vitamin E, phospholipids and other nutrients, it can nourish hair follicles and promote hair growth.

[0037] (7) Eucommia bark extract: It is rich in lignin, phenylpropanoid compounds, and a variety of minerals and trace elements. It can promote the metabolism of collagen in the body, enhance cell vitality, thereby nourishing hair follicles and promoting hair growth.

[0038] The extracts in the above skin auxiliary conditioners and hair auxiliary conditioners are all conventional Chinese medicine ingredients. Most of the ingredients are used for skin anti-oxidation, and a small part is used in shampoo. However, there are few reports on the use of these ingredients in products for stopping hair loss and promoting hair growth. In the research on the products for stopping hair loss and promoting hair growth of the present invention, the applicant unexpectedly found that due to the different effects of each ingredient, it can play a different role in the special environment of the head hair follicle tissue, and can also cover the side effects of different Chinese medicine ingredients. The compounding of each ingredient can achieve the best effect of stopping hair loss and promoting hair growth.

[0039] Furthermore, the above extracts can be purchased from manufacturers such as Sichuan Xiaoye Bencao Biotechnology Co., Ltd. and Snort Biotechnology, but the test results of pesticide residues such as acephate, hexachloride, DDT, paraquat, and permethrin in the extracts must meet the standard requirements. They can also be extracted through the following preparation process:

[0040] An extraction process of a Chinese medicine extract comprises the following steps:

[0041] S1: Raw material selection and testing. After the raw materials are selected and tested, qualified products are placed in the qualified area;

[0042] S2: weighing;

[0043] S3: Cleaning: Clean the raw materials by high-pressure water or drum-type equipment, wherein the pressure of the high-pressure water is 0.1Mpa-0.2Mpa, water is passed through the drum-type equipment, and the drum speed is 100rpm-200rpm;

[0044] S4: Dehydration: dehydrating the raw material through a dehydration device, with a centrifugal speed of 1000rpm-1500rpm;

[0045] S5: Sterilization: sterilize the raw materials through ultraviolet sterilization equipment, the ultraviolet wavelength is 240-260nm;

[0046] S6: extraction, by placing the raw material in an extraction device, mincing it with a mincing and stirring device, adding water and other additives, soaking for 1-2 hours, and then heating to 120°C-150°C to obtain a distillate and a residual liquid; the mass ratio of the additive to the raw material is 10:1;

[0047] S6: Deslagging, the residual liquid is deslagging through a deslagging device to obtain an extract; the deslagging device is a centrifuge;

[0048] S7: Filtration, filtering the extract through microfiltration, ultrafiltration and other steps in sequence to obtain a filtrate; microfiltration is performed by a PP filter element or activated core carbon, and ultrafiltration is performed by an ultrafiltration device;

[0049] S8: Concentration: The collected filtrate and distillate are placed in a concentration device for concentration. The heating temperature of the concentration device is 100°C-120°C. After the additives are volatilized, the product is obtained.

[0050] The Chinese herbal medicine extract is the extract mentioned in the present invention. Through the above-mentioned extraction steps, the pesticide residues in the Chinese herbal medicine can be reduced. The detection results of pesticide residues such as acephate, benzyl hexachloride, DDT, paraquat, and permethrin are undetectable, which meets the standard requirements.

[0051] Furthermore, the preservative is compounded by p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of (0.1-1): (0.1-1). Preferably, the preservative is compounded by p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of 1:1, and the preservative is 1% of the total weight of the composition. The above compounded preservative has the effect of further inhibiting the reproduction of microorganisms in the composition, and also has the effect of reducing the biological activity of the active ingredients in the composition when the composition is stored, ensuring that the activity of the active ingredients stimulated when the composition is used is maintained at a high level.

[0052] Furthermore, the moisturizing agent is but not limited to butylene glycol. Through the action of butylene glycol, the synergistic effect between the components can be promoted, and the moisture of the hair can be maintained, thereby promoting its growth.

[0053] Furthermore, the mass ratio of the ginger root extract to the skin auxiliary conditioning agent is 1:(3-4), such as 1:3, 1:3.5, 1:4, etc.; the mass ratio of the Polygonum multiflorum extract to the hair auxiliary conditioning agent is 1:(0.8-1), such as 1:0.8, 1:0.9, 1:1, etc.

[0054] Preferably, the mass ratio of the ginger root extract to the skin auxiliary conditioning agent is 1.5:5.66; the mass ratio of the Polygonum multiflorum extract to the hair auxiliary conditioning agent is 1.43:1.41.

[0055] Further preferably, the skin auxiliary conditioning agent is composed of Gleditsia sinensis seed extract, Lithospermum officinale root extract, Artemisia argyi extract, Clove flower extract, Tea leaf extract, Coptis chinensis root extract, Evodia rutaecarpa fruit extract, Mulberry leaf extract, Phellodendron amurense bark extract, Capsicum fruit extract, Sapindus mukorossi fruit extract, Cyperus rotundus root extract, Paeonia lactiflora root extract in a mass ratio of 1:1:1:1:1:0.1:0.1:0.1:0.1:0.1:0.01:0.05;

[0056] The auxiliary hair conditioning agent is composed of safflower flower extract, salvia miltiorrhiza root extract, Ligustrum lucidum fruit extract, Channa intestine extract, Pueraria root extract, Cuscuta seed extract and Eucommia bark extract in a mass ratio of 1:0.1:0.1:0.1:0.05:0.05:0.01.

[0057] Furthermore, the properties of the hair loss prevention and hair growth composition are as follows: (1) Appearance: brown-yellow liquid; (2) pH value: 2.0-8.0.

[0058] The second object of the present invention is achieved by adopting the following technical solution:

[0059] A method for preparing a hair loss prevention and hair growth composition comprises the following preparation steps:

[0060] S1: adding ginger root extract and skin auxiliary conditioning agent to part of the water, mixing them evenly, and then dispersing the ginger root extract in the skin auxiliary conditioning agent and water through 30-40KHz ultrasonic treatment to obtain a first liquid, wherein water accounts for 3 / 4 of the total water volume;

[0061] S2: adding the Polygonum multiflorum extract and the hair auxiliary conditioning agent to the remaining water, mixing them evenly, and then dispersing the Polygonum multiflorum extract in the hair auxiliary conditioning agent and the water through 20-30KHz ultrasonic treatment to obtain a second liquid;

[0062] S3: Add the second liquid to the first liquid while stirring, and complete the addition within 3-5 minutes. Then add the preservative and moisturizer in sequence and stir evenly.

[0063] In the above preparation steps, the components can be evenly dispersed without destroying the effective ingredients of each Chinese medicine extract, and the synergistic effect of each component can be promoted. After compounding, the second liquid is dispersed in the first liquid, and after the first liquid acts on the scalp, the second liquid acts on the hair to avoid excessive accumulation of the effective ingredients on the head, which affects its efficacy.

[0064] The third object of the present invention is achieved by adopting the following technical solution:

[0065] A hair care cosmetic containing the anti-hair loss and hair growth composition comprises the anti-hair loss and hair growth composition described above.

[0066] Furthermore, the hair care cosmetic is an anti-hair loss shampoo or an anti-hair loss and hair growth liquid.

[0067] Furthermore, when the hair care cosmetic is an anti-hair loss shampoo, the amount of the anti-hair loss and hair growth composition added is 15-40% of the total mass. Preferably, the amount of the anti-hair loss and hair growth composition added is 15-20% of the total mass, such as 15%, 16%, 17%, 18%, 19%, 20%.

[0068] Furthermore, when the hair care cosmetic is a hair loss prevention and hair growth liquid, the amount of the hair loss prevention and hair growth composition added is 15-50% of the total mass. Preferably, the amount of the hair loss prevention and hair growth composition added is 25-30% of the total mass, such as 25%, 26%, 27%, 28%, 29%, 30%.

[0069] Compared with the prior art, the present invention has the following beneficial effects:

[0070] 1. The hair loss prevention and hair growth composition of the present invention is rich in active ingredients such as ginsenosides, ferulic acid, polysaccharides, alkaloids, flavonoids, volatile oils, etc. by adding skin auxiliary conditioners and hair auxiliary conditioners to the components of ginger root extract and Polygonum multiflorum extract. The skin auxiliary conditioners and ginger root extract can effectively improve the hair microenvironment, inhibit sebum secretion, and prolong the hair survival cycle. On the other hand, the irritation of certain components in ginger can also be avoided, thereby achieving an effective hair loss prevention effect. While comprehensively preventing hair loss, the hair auxiliary conditioners and Polygonum multiflorum extract can regulate the blood supply to the key parts of the hair follicle cycle growth, enhance the vitality of the hair, and strengthen the hair roots, thereby achieving a comprehensive solution to various problems such as seborrheic alopecia, neurotic alopecia, diffuse alopecia, and nutritional alopecia. On the basis of the above effective ingredients, preservatives, moisturizers, water and other ingredients are added to enable the composition to be more fully compounded to improve its efficacy.

[0071] 2. The test results of pesticide residues such as acephate, hexachloride, DDT, paraquat, and permethrin in the traditional Chinese medicine extracts used in the present invention meet the standard requirements, so as to improve the safety performance of the product and reduce the impact of residual pesticide components on the efficacy of the traditional Chinese medicine extracts. BRIEF DESCRIPTION OF THE DRAWINGS

[0072] Figure 1 The present invention is a flow chart of the preparation process of the Chinese medicine extract. DETAILED DESCRIPTION

[0073] The present invention is further described below in conjunction with specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0074] Examples 1-7

[0075] A hair loss prevention and hair growth composition is composed of the following components:

[0076] Ginger root extract; Polygonum multiflorum extract; skin conditioning agent; hair conditioning agent; preservative; humectant; water.

[0077] Among them, the skin auxiliary conditioning agent is composed of Gleditsia sinensis seed extract, Lithospermum officinale root extract, Artemisia argyi leaf extract, Clove flower extract, Tea leaf extract, Coptis root extract, Evodia rutaecarpa fruit extract, Mulberry leaf extract, Phellodendron bark extract, Capsicum fruit extract, Sapindus mukorossi fruit extract, Cyperus rotundus root extract, Paeonia lactiflora root extract; the hair auxiliary conditioning agent is composed of Carthamus tinctorius flower extract, Salvia miltiorrhiza root extract, Ligustrum lucidum fruit extract, Channa intestine extract, Pueraria root extract, Cuscuta chinensis seed extract, Eucommia bark extract. The above extracts and ginger root extract, Polygonum multiflorum extract and other extracts are all commercially available, water-extracted extracts, extraction ratio 10:1, and the detection results of pesticide residues meet the standard requirements.

[0078] The preservative is compounded by p-hydroxyacetophenone and 1,2-hexanediol. The p-hydroxyacetophenone is commercially available, CAS number: 99-93-4, brand: Handafei; 1,2-hexanediol is commercially available, CAS number: 6920-22-5, brand: Wei Chemical.

[0079] The moisturizer is butylene glycol (1,4-butylene glycol), which is commercially available, CAS number: 110-63-41, brand: Wenru.

[0080] The water is purified water.

[0081] The preparation method thereof comprises the following preparation steps:

[0082] S1: adding ginger root extract and skin auxiliary conditioning agent to 3 / 4 of water, mixing evenly, and then dispersing the ginger root extract in the skin auxiliary conditioning agent and water through 35KHz ultrasonic treatment to obtain a first liquid;

[0083] S2: adding the Polygonum multiflorum extract and the hair auxiliary conditioning agent to the remaining water, mixing them evenly, and then dispersing the Polygonum multiflorum extract in the hair auxiliary conditioning agent and the water through 25KHz ultrasonic treatment to obtain a second liquid;

[0084] S3: Add the second liquid to the first liquid while stirring, and complete the addition within 4 minutes. Then add the preservative and moisturizer in sequence and stir evenly.

[0085] The specific input amount of each component in Examples 1-3 is shown in Table 1, and the unit of the amount in Table 1 is kg.

[0086] Table 1

[0087]

[0088]

[0089] Compared with Example 1, Examples 2-3 changed the content of ginger root extract and skin auxiliary conditioning agent, Examples 4-5 changed the content of Polygonum multiflorum extract and hair auxiliary conditioning agent, and Examples 6-7 changed the ratio of preservatives.

[0090] Example 8

[0091] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that the extracts in the composition are Figure 1 The test results of pesticide residues such as acephate, hexachloride, DDT, paraquat and permethrin were not detected, which met the standard requirements.

[0092] The specific extraction process includes the following steps:

[0093] S1: Raw material selection and testing. After the raw materials are selected and tested, qualified products are placed in the qualified area;

[0094] S2: weighing;

[0095] S3: Cleaning: Clean the raw materials by high-pressure water or drum-type equipment, wherein the pressure of the high-pressure water is 0.1 MPa, water is passed through the drum-type equipment, and the drum speed is 100 rpm;

[0096] S4: Dehydration: dehydrating the raw material through a dehydration device, with a centrifugal speed of 1000 rpm;

[0097] S5: Sterilization: sterilize the raw materials through ultraviolet sterilization equipment, the ultraviolet wavelength is 240nm;

[0098] S6: extraction, by placing the raw material in an extraction device, mincing it through a mincing and stirring device, adding water and other additives, soaking for 2 hours, and then heating to 120° C. to obtain a distillate and a residue liquid; the mass ratio of the additive to the raw material is 10:1;

[0099] S6: Deslagging, the residual liquid is deslagging through a deslagging device to obtain an extract; the deslagging device is a centrifuge;

[0100] S7: Filtration, filtering the extract through microfiltration, ultrafiltration and other steps in sequence to obtain a filtrate; microfiltration is performed by a PP filter element or activated core carbon, and ultrafiltration is performed by an ultrafiltration device;

[0101] S8: Concentration: The collected filtrate and distillate are placed in a concentration device for concentration. The heating temperature of the concentration device is 100° C., and the product is obtained after the additives are volatilized.

[0102] Comparative Example 1

[0103] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the skin auxiliary conditioning agent.

[0104] Comparative Example 2

[0105] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the Gleditsia sinensis seed extract.

[0106] Comparative Example 3

[0107] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the lithospermum root extract.

[0108] Comparative Example 4

[0109] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of the wormwood leaf extract.

[0110] Comparative Example 5

[0111] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the lilac flower extract.

[0112] Comparative Example 6

[0113] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of tea extract.

[0114] Comparative Example 7

[0115] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of the Coptis chinensis root extract.

[0116] Comparative Example 8

[0117] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the Evodia rutaecarpa fruit extract.

[0118] Comparative Example 9

[0119] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the mulberry leaf extract.

[0120] Comparative Example 10

[0121] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of the Phellodendron amurense bark extract.

[0122] Comparative Example 11

[0123] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the capsicum fruit extract.

[0124] Comparative Example 12

[0125] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the soapberry fruit extract.

[0126] Comparative Example 13

[0127] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the Cyperus rotundus root extract.

[0128] Comparative Example 14

[0129] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the peony root extract.

[0130] Comparative Example 15

[0131] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the hair auxiliary conditioning agent.

[0132] Comparative Example 16

[0133] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the safflower flower extract.

[0134] Comparative Example 17

[0135] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the salvia miltiorrhiza root extract.

[0136] Comparative Example 18

[0137] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the Ligustrum lucidum fruit extract.

[0138] Comparative Example 19

[0139] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of the Channa intestine extract.

[0140] Comparative Example 20

[0141] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the kudzu root extract.

[0142] Comparative Example 21

[0143] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used instead of the dodder seed extract.

[0144] Comparative Example 22

[0145] A hair loss prevention and hair growth composition, compared with Example 1, the only difference is that an equal amount of water is used to replace the eucommia bark extract.

[0146] Performance Testing

[0147] 1. 5a-Reductase Inhibition Assay

[0148] (1) Experimental principle

[0149] Androgenic alopecia (AGA) is caused by the conversion of testosterone (T) into the more active dihydrotestosterone (DHT) under the action of 5a-reductase, which is sensitive to hair follicles, affects hair follicle development, and causes hair loss. By analyzing whether the test substance can inhibit 5a-reductase and thus inhibit the production of DHT, it can be used as one of the bases for judging whether it has the effect of preventing hair loss and promoting hair growth.

[0150] (2) Experimental Materials

[0151] Type II 5a-reductase: extracted from rat prostate tissue and stored at -80°C;

[0152] Positive control: finasteride 10ug / mL;

[0153] Blank control: phosphate buffered saline (PBS);

[0154] Sample preparation: The samples of Examples 1-5, Example 8, and Comparative Examples 1-14 were diluted with PBS to a concentration of 20%.

[0155] (3) Efficacy test evaluation

[0156] The effects are shown in Table 2.

[0157] Table 2

[0158]

[0159]

[0160] As can be seen from the above table, compared with Example 1, Examples 2-3, due to the change of the ratio between the ginger root extract and the skin auxiliary conditioner and the change of each component in the skin auxiliary conditioner, the 5a-reductase inhibition effect is not as good as that of Example 1, while Examples 4-5, due to only changing the ratio between the Polygonum multiflorum extract and the hair auxiliary conditioner and the change of each component in the hair auxiliary conditioner, but because some hair auxiliary conditioners also have antibacterial effects, when the ratio between the ginger root extract and the skin auxiliary conditioner remains unchanged, the 5a-reductase inhibition effect is not much different from that of Example 1, and in Example 8, due to the less pesticide residues contained in the extract, its 5a-reductase inhibition effect is the best. In Comparative Examples 1 to Comparative Examples 14, due to the deletion of one of the components in the skin auxiliary conditioner, the 5a-reductase inhibition effect is slightly different.

[0161] 2. Anti-hair loss experiment

[0162] (1) Sample: Dilute Examples 1 to 8 and Comparative Examples 1 to 14 to a concentration of 20% with purified water.

[0163] (2) Several volunteers with severe hair loss, aged 40-50 years old, with an equal number of males and females (i.e., half males and half females), were recruited and divided into 22 groups, with 10 people in each group. Before bathing, the samples were applied once to the roots of the hair and rinsed off after half an hour. The samples were applied continuously for 4 days. The hair of each group was observed under a reflective optical microscope to count the repair status of the scale structure of the hair cuticle at the marked position. The damaged part of the hair cuticle was obviously filled and the scales were obviously attached to the cortical layer, which was considered to be effectively repaired. The repair rate (%) was calculated according to the following formula: Repair rate (%) = (total number of repaired hair cuticles / total number of damaged scales) × 100%.

[0164] (3) Test results are shown in Table 3 below.

[0165] Table 3

[0166]

[0167] It can be seen from the above table that, compared with Comparative Examples 1 to 14, the products of Examples 1 to 8 have better anti-hair loss effects.

[0168] 3. Hair growth experiment

[0169] (1) Samples: Example 1-Example 8, Comparative Examples 1-22.

[0170] (2) Recruit a number of volunteers with severe hair loss and baldness, aged 50-55 years old, with an equal number of men and women (i.e., half men and half women), and divide them into 30 groups, with 10 people in each group. Apply the sample once to the roots of the hair before bathing, rinse it off after half an hour, and continue applying for 2 months. Collect their evaluations on the effects on hair loss and hair growth, among which 0-3.9 points: basically no effect; 4-6.9 points: average effect, but there is improvement, and fine hair is generated; 7-10 points: obvious effect, hair becomes thicker, and various small hairs are generated. Take the average score and retain one decimal place.

[0171] (3) Test results are shown in Table 4 below.

[0172] Table 4

[0173]

[0174]

[0175] It can be seen from the above table that, compared with Comparative Examples 1 to 22, the products of Examples 1 to 8 have better hair growth effects.

[0176] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A hair loss prevention and hair growth composition, characterized in that: It is composed of the following components in parts by weight: 1-2 parts of ginger root extract; 1-2 parts of Polygonum multiflorum extract; 2.58-8.3 parts of skin conditioning agent; 0.56-2.1 parts of hair conditioning agent; 0.1-2 parts of preservative; 5-15 parts of moisturizer; 70-85 parts of water; The skin auxiliary conditioning agent is composed of Gleditsia sinensis seed extract, Lithospermum officinale root extract, Artemisia argyi leaf extract, Clove flower extract, Tea tree extract in a mass ratio of (0.5-1.5): (0.5-1.5): (0.5-1.5): (0.5-1.5): (0.01-0.1): (0.01-0.1): (0.01-0.1): (0.01-0.1): (0.01-0.1): (0.01-0.1): (0.01-0.1) The invention relates to a skin conditioning agent comprising a leaf extract, a coptis root extract, an evodia rutaecarpa fruit extract, a mulberry leaf extract, a phellodendron bark extract, a capsicum fruit extract, a soapberry fruit extract, a cyperus root extract and a peony root extract; the mass ratio of the ginger root extract to the skin conditioning agent is 1:(3-4); the mass ratio of the polygonum multiflorum extract to the hair conditioning agent is 1:(0.8-1); the preservative is a compound of p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of (0.1-1):(0.1-1); the moisturizer is butylene glycol; The auxiliary hair conditioning agent is composed of safflower flower extract, salvia miltiorrhiza root extract, Ligustrum lucidum fruit extract, Channa intestine extract, Pueraria root extract, Cuscuta seed extract and Eucommia bark extract in a mass ratio of (0.5-1.5):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1):(0.01-0.1); The properties of the hair loss prevention and hair growth composition are as follows: (1) Appearance: brownish yellow liquid; (2) pH value: 2.0-8.0; The preparation of the hair loss prevention and hair growth composition comprises the following steps: S1: adding ginger root extract and skin auxiliary conditioning agent to part of water, mixing evenly, and then subjecting to 30-40KHz ultrasonic treatment to obtain a first liquid; S2: adding the Polygonum multiflorum extract and the hair auxiliary conditioning agent to the remaining water, mixing them evenly, and then subjecting them to 20-30KHz ultrasonic treatment to obtain a second liquid; S3: Add the second liquid to the first liquid while stirring, and complete the addition within 3-5 minutes. Then add the preservative and moisturizer in sequence and stir evenly.

2. A method for preparing the anti-hair loss and hair growth composition according to claim 1, characterized in that: The method comprises the following preparation steps: S1: adding ginger root extract and skin auxiliary conditioning agent to part of water, mixing evenly, and then subjecting to 30-40KHz ultrasonic treatment to obtain a first liquid; S2: adding the Polygonum multiflorum extract and the hair conditioning agent to the remaining water, mixing them evenly, and then subjecting them to 20-30KHz ultrasonic treatment to obtain a second liquid; S3: Add the second liquid to the first liquid while stirring, and complete the addition within 3-5 minutes. Then add the preservative and moisturizer in sequence and stir evenly.

3. A hair care cosmetic containing a hair loss prevention and hair growth composition, characterized in that: The invention comprises the composition for preventing hair loss and promoting hair growth as claimed in claim 1.

4. The hair care cosmetic according to claim 3, characterized in that: The hair care cosmetic is an anti-hair loss shampoo or an anti-hair loss and hair growth liquid.

5. The hair care cosmetic according to claim 4, characterized in that: When the hair care cosmetic is an anti-hair loss shampoo, the amount of the anti-hair loss and hair growth composition added is 15-40% of the total mass.

6. The hair care cosmetic according to claim 4, characterized in that: When the hair care cosmetic is a hair loss prevention and hair growth liquid, the amount of the hair loss prevention and hair growth composition added is 15-50% of the total mass.

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