A preparation method of silymarin phospholipid complex and a special stirring reactor

Abstract

The present invention relates to the field of plant extract processing, and particularly to a preparation method of silymarin phospholipid complex and a special stirring reactor therefor. In a preparation method of silymarin phospholipid complex of the present invention, by controlling the specification / addition ratio of phospholipids in the same process, after complexing with silymarin, water precipitation is carried out, and water-soluble impurities in the raw materials are separated and removed while preparing the silymarin phospholipid complex, further increasing the content of active ingredients. A special stirring reactor for preparing silymarin phospholipid complex of the present invention has three functions of successively completing the stirring and mixing treatment of two kinds of liquid materials, the filtration treatment of precipitation and solvent, and the drying and pulverizing treatment of precipitation, realizing that multiple treatment processes are completed by one machine, saving the time consumed by material transfer in each treatment step and the equipment operation cost, and greatly improving the production efficiency of silymarin phospholipid complex.

Description

Technical Field

[0001] The present invention relates to the field of plant extract processing, and particularly relates to a preparation method of silymarin phospholipid complex and a special stirring reactor therefor. Background Art

[0002] Silybum marianum (L.) Gaertn., also known as Silybum marianum, milk thistle, rat tendon, and milk thistle seed, is an annual or biennial herbaceous plant of the genus Silybum in the Compositae family. It has a plant height of 1.2 m, a straight and ridged stem, many branches, smooth or covered with arachnoid hair. The leaves are alternate, and the basal rosette leaves often lie flat on the ground, oblong-lanceolate, pinnately lobed or shallowly undulate-crenate at the edge, green with milky white markings. The capitulum is terminal, the tubular flowers are red-purple, rarely white, the achenes are oblong, dark brown or black, and the flowering and fruiting periods are from May to October. Silybum marianum generally grows in wasteland and is naturally distributed in rocky areas near the sea and dry. Silybum marianum has high application value. Its flowers are large and the leaf patterns are beautiful, so it can be used as an ornamental plant; the seedlings are edible; the extract has the functions of clearing heat and detoxifying, soothing the liver and gallbladder, and is used for damp-heat in the liver and gallbladder, hypochondriac pain, and jaundice.

[0003] In addition, Silybum marianum also plays an important role in agriculture as feed, green manure, honey source, etc. Experiments have proved that silybin has an obvious protective effect on liver damage caused by various liver toxins; silybin, silydianin, and silychristin all have the function of stabilizing cells and intracellular biological membranes and are a class of anti-hepatitis virus active substances. In addition, silybinol has the effect of promoting bile secretion; silybin can inhibit formaldehyde-induced peritonitis and multiple arthritis in rats caused by immune reactions; intravenous injection of 30 mg / kg of silybin in dogs and rats can cause blood pressure drop and heart rate slowdown; through animal experiments, no obvious toxicity of Silybum marianum has been observed, and no side effects or toxic reactions to embryos have been found.

[0004] Silybum marianum is a component that has been found to be relatively good for protecting the liver. The seeds of Silybum marianum contain the flavonoid natural product silymarin. Silymarin is an antioxidant that can strengthen the stability of the outer membrane of hepatocytes and has a liver-protecting effect. As a popular raw material for protecting the liver, Silybum marianum is currently used as the main active ingredient in the vast majority of liver-protecting products on the market, such as the liver-protecting tablets of SWISSE and the silymarin capsules of Wonderlab.

[0005] At present, the raw materials of silymarin extract on the market use silymarin molecules or silybin molecules as the efficacy index components. Hereinafter, silymarin molecules and silybin molecules are collectively referred to as silymarin active molecules. These components all have the problem of low bioavailability. Therefore, when consumers take silymarin liver-protecting products, due to the fact that silymarin active molecules are difficult to be absorbed and utilized by the human body, the efficacy is very low, or a large amount of products need to be taken to barely have an effect. How to improve the bioavailability of silymarin extract and how to ensure the efficacy of silymarin liver-protecting products have always been difficult problems to be solved in the liver-protecting direction of the big health field. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a preparation process of silymarin extract and corresponding supporting production equipment to improve the bioavailability of the main efficacy component in silymarin - silymarin active molecules.

[0007] A preparation method of silymarin phospholipid complex includes the following steps:

[0008] Step 1: Press the silymarin medicinal materials to extract oil first, and then remove all the oil in the medicinal materials;

[0009] Step 2: Extract the defatted medicinal materials in Step 1 with an organic solvent with a concentration of 80% in two steps. In the first step, use 10 times the amount of the organic solvent to extract for 2 hours, and in the second step, use 8 times the amount of the organic solvent to extract for 1.5 hours. Combine the extraction liquids obtained in the two steps, and concentrate the combined extraction liquid to a solid content of 20%;

[0010] Step 3: Transfer the concentrated extraction liquid in Step 2 to an interlayer pot with heating and stirring for heating and insulation. The heating and insulation temperature is 50°C - 70°C. At the same time, add 20% - 40% of the phospholipid mixture based on the amount of the liquid material and 1% - 5% of the composite emulsifier based on the amount of the liquid material to obtain a crude solution. Among them, the phospholipid mixture formula, the composite emulsifier formula, the stirring temperature and time are the key to determining the process effect, which determines the effect of forming a complex between phospholipid molecules and silymarin active molecules;

[0011] Step 4: Co - dissolve and compound. Stir the crude solution obtained in Step 3 for 3 - 6 hours in a temperature environment of 50°C - 70°C to allow phospholipid molecules and silymarin active molecules to form a complex, obtaining a composite solution. At this time, there are alcohol - soluble silymarin phospholipid complexes and water - soluble components in silymarin in the solution;

[0012] Step 5: Prepare pure water with a mass number 1 - 5 times that of the composite solution in Step 4 in another interlayer pot;

[0013] Step 6: The composite solution in Step 4 and the pure water in Step 5 are respectively fed into the stirring reaction kettle through pipelines according to specified ratios, and the high-speed shear emulsifying head installed in the stirring reaction kettle is used to fully mix, shear and emulsify the fed liquid materials, so that the two liquid materials are more uniformly mixed. At the same time, the stirring reaction kettle stirs and precipitates the liquid materials, and the precipitation is collected by the stirring reaction kettle. Since a large number of water molecules compete for ethanol molecules, the water-soluble silymarin phospholipid complex will precipitate in the form of precipitation.

[0014] Step 7: After filtering the silymarin phospholipid precipitate collected in the stirring reaction kettle, it is dried and pulverized, and the remaining solvent is recovered.

[0015] Further explanation: The organic solvents used in Step 2 include ethanol, ethyl acetate and methanol.

[0016] Further explanation: The phospholipid mixture used in Step 3 is one or more of soybean phospholipid, lecithin, sunflower phospholipid, phosphatidylserine, and L-α-glycerylphosphorylcholine; the composite emulsifier used in Step 3 is one or more of monoglyceride and diglyceride fatty acid esters, polyglycerol fatty acid esters, Tween 20, Tween 80, and sucrose fatty acid esters.

[0017] Further explanation: In Step 7, a glidant is added during the drying and pulverizing process of the precipitate to improve the flow effect of the precipitate.

[0018] A special stirring reaction kettle for preparing silymarin phospholipid complex, comprising a mounting frame, a kettle tank, a collection basin, a main pipeline, an electric lifting push rod, a housing, an electric rotating shaft, a rotating disk, a shear fan blade, a grinding block, a retaining ring and a compression spring; the mounting frame is provided with the kettle tank; a drain pipe is connected inside the kettle tank; a collection basin is inserted into the kettle tank, and the collection basin initially blocks the drain pipe; an electric control valve is arranged inside the main pipeline; a cavity structure is arranged inside the collection basin; the bottom of the kettle tank is slidably connected with the main pipeline; the main pipeline is connected to the cavity structure of the collection basin; a plurality of suction hole structures communicating with the cavity structure are arranged inside the collection basin; an annular vertical groove structure communicating with the suction hole structure is arranged inside the collection basin; the mounting frame is provided with the electric lifting push rod; the telescopic end of the electric lifting push rod is fixedly connected with the main pipeline; a housing is fixedly connected inside the kettle tank; a plurality of side hole structures are arranged on the housing; an electric rotating shaft is rotatably connected between the kettle tank and the housing; the electric rotating shaft is fixedly connected with the rotating disk, and the rotating disk is located inside the housing; a plurality of shear fan blades are fixedly connected to the lower side of the rotating disk; the shear fan blades are fixedly connected with the grinding block; a retaining ring for blocking the suction hole structure is slidably connected inside the collection basin; a compression spring is fixedly connected between the retaining ring and the collection basin; a plurality of air guide hole structures are arranged on the retaining ring; a first screen is fixedly connected to the air guide hole structure of the retaining ring; a plurality of drain hole structures are arranged at the bottom of the retaining ring; a brush is fixedly connected to the grinding block.

[0019] Further explanation: A second screen is fixedly connected to the drain hole structure of the retaining ring.

[0020] Further description: An air delivery pipe is fixedly connected inside the kettle; the air delivery pipe is connected to the housing.

[0021] Further description: A retaining ring structure is provided on the rotating disk; a ventilation hole structure is provided on the rotating disk.

[0022] Further description: A feeding branch pipe is connected to the air delivery pipe.

[0023] Beneficial effects: A preparation method of silymarin phospholipid complex of the present invention controls the specification / addition ratio of phospholipids during the same process, and after compounding with silymarin, it is precipitated by water. While preparing the silymarin phospholipid complex, water-soluble impurities in the raw materials are separated and removed, further improving the content of active ingredients; A special stirring reaction kettle for preparing silymarin phospholipid complex of the present invention has three functions of successively completing the stirring and mixing treatment of two kinds of liquid materials, the filtration treatment of precipitation and solvent, and the drying and pulverizing treatment of precipitation, realizing that multiple treatment processes are completed by one machine, saving the time consumed by material transfer in each treatment step and the equipment operation cost, and greatly improving the production efficiency of silymarin phospholipid complex. Description of the drawings

[0024] Figure 1 It is a three-dimensional structure diagram of the stirring reaction kettle of the present invention;

[0025] Figure 2 It is a sectional view of the kettle of the stirring reaction kettle of the present invention;

[0026] Figure 3 It is a sectional view of the housing of the stirring reaction kettle of the present invention;

[0027] Figure 4 It is a three-dimensional structure diagram of the grinding block of the stirring reaction kettle of the present invention;

[0028] Figure 5 It is a three-dimensional structure diagram of the retaining ring and compression spring of the stirring reaction kettle of the present invention;

[0029] Figure 6 It is a sectional view of the collection basin of the stirring reaction kettle of the present invention;

[0030] Figure 7 It is a three-dimensional structure diagram of the retaining ring of the stirring reaction kettle of the present invention;

[0031] Figure 8 It is a sectional view of the combined state of the housing and the collection basin of the stirring reaction kettle of the present invention.

[0032] Reference numerals: 1 - mounting bracket, 2 - kettle, 21 - drain pipe, 3 - collection basin, 301 - cavity structure, 302 - suction hole structure, 303 - annular vertical groove structure, 31 - main pipe, 32 - electric lifting push rod, 4 - housing, 401 - side hole structure, 41 - electric rotating shaft, 42 - rotating disk, 4201 - ventilation hole structure, 421 - retaining ring structure, 43 - shear fan blade, 44 - grinding block, 45 - brush, 5 - retaining ring, 501 - air guide hole structure, 502 - drain hole structure, 51 - first sieve, 52 - second sieve, 53 - compression spring, 6 - gas transmission pipe, 61 - feeding branch pipe. Detailed implementation manners

[0033] The present invention will be specifically described below with reference to the drawings.

[0034] Example 1

[0035] A preparation method of silymarin phospholipid complex includes the following steps:

[0036] Step 1: First press the silymarin medicinal materials to extract oil, and then remove all the oil from the medicinal materials.

[0037] Step 2: Use an organic solvent with a concentration of 80% to concentrate the extract obtained from the defatted medicinal materials in Step 1 to a solid content of 20%.

[0038] Step 3: Transfer the concentrated extract in Step 2 to an interlayer pot with heating and stirring, heat and keep warm at a temperature of 60°C, and at the same time add a phospholipid mixture of 30% of the amount of the material liquid of soybean phospholipid and 10% of the amount of the material liquid of lecithin, and a compound emulsifier of 3% of the amount of the material liquid of mono- and diglycerol fatty acid esters and 1% of the amount of the material liquid of Tween 20 to obtain a crude solution. The phospholipid mixture formula, the compound emulsifier formula, the stirring temperature and time are the key to determining the process effect, which determines the effect of forming a complex between phospholipid molecules and effective silymarin molecules.

[0039] Step 4: Co-dissolve and compound. Stir the crude solution obtained in Step 3 at a temperature of 60°C for 4 hours to allow phospholipid molecules and effective silymarin molecules to form a complex, obtaining a complex solution. At this time, the solution contains an alcohol-soluble silymarin phospholipid complex and water-soluble components in silymarin.

[0040] Step 5: Prepare pure water with a mass number 3 times that of the complex solution in Step 4 in another interlayer pot.

[0041] Step 6: The composite solution in Step 4 and the pure water in Step 5 are respectively fed into the stirring reactor through pipelines according to specified ratios, and the high-speed shear emulsifying head installed in the stirring reactor is used to fully mix, shear, and emulsify the fed liquid materials, making the two liquid materials mix more uniformly. At the same time, the stirring reactor stirs and precipitates the liquid materials, and the stirring reactor collects the precipitate. Since a large number of water molecules compete for ethanol molecules, the water-soluble silybin phospholipid complex will precipitate out in the form of a precipitate.

[0042] Step 7: After filtering the silybin phospholipid precipitate collected in the stirring reactor, it is dried and pulverized, and at the same time, a glidant is added to improve the flow effect of the precipitate, and the remaining solvent is recovered.

[0043] The organic solvent used in Step 2 includes ethanol.

[0044] The phospholipid mixture used in Step 3 is soybean phospholipid and lecithin.

[0045] The composite emulsifier used in Step 3 is mono- and diglycerol fatty acid esters and Tween 20.

[0046] Example 2

[0047] A method for preparing silybin phospholipid complex, comprising the following steps:

[0048] Step 1: Press the silybin medicinal materials to extract oil first, and then remove the oil in the medicinal materials completely.

[0049] Step 2: Extract the defatted medicinal materials in Step 1 with an organic solvent with a concentration of 80% in two steps. In the first step, use 10 times the amount of the organic solvent to extract for 2 hours, and in the second step, use 8 times the amount of the organic solvent to extract for 1.5 hours. Combine the extraction liquids obtained in the two steps, and concentrate the combined extraction liquid to a solid content of 20%.

[0050] Step 3: Transfer the concentrated extraction liquid in Step 2 to a jacketed pot with heating and stirring, heat and keep warm at a temperature of 50°C. At the same time, add a phospholipid mixture of 20% of the soybean phospholipid and 20% of phosphatidylserine based on the amount of the liquid material, and a composite emulsifier of 1% of mono- and diglycerol fatty acid esters and 1% of polyglycerol fatty acid esters based on the amount of the liquid material to obtain a crude solution. Among them, the phospholipid mixture formula, the composite emulsifier formula, the stirring temperature and time are the key to determining the process effect, which determines the effect of forming a complex between phospholipid molecules and effective silybin molecules.

[0051] Step 4: Co-dissolve and compound. Stir the crude solution obtained in Step 3 for 3 hours at a temperature of 50°C to allow phospholipid molecules and effective silybin molecules to form a complex, obtaining a composite solution. At this time, there are water-soluble silybin phospholipid complexes and water-soluble components in silybin in the solution.

[0052] Step 5: Prepare pure water with a mass number 1 times that of the composite solution in Step 4 in another sandwich pot;

[0053] Step 6: Respectively introduce the composite solution in Step 4 and the pure water in Step 5 into the stirring reaction kettle through pipelines according to specified ratios, and use the high-speed shearing emulsifying head installed in the stirring reaction kettle to fully mix, shear and emulsify the introduced feed liquids, so that the two feed liquids are more uniformly mixed. At the same time, the stirring reaction kettle stirs and precipitates the feed liquids, and collects the precipitate by the stirring reaction kettle. Since a large number of water molecules compete for ethanol molecules, the water-soluble silybin phospholipid complex will precipitate in the form of a precipitate;

[0054] Step 7: After filtering the silybin phospholipid precipitate collected in the stirring reaction kettle, perform drying and pulverization treatment on it. At the same time, add a glidant to improve the flow effect of the precipitate, and recover the remaining solvent.

[0055] The organic solvent used in Step 2 includes ethanol.

[0056] The phospholipid mixture used in Step 3 is soy phospholipid and phosphatidylserine.

[0057] The composite emulsifier used in Step 3 is mono- and diglycerol fatty acid esters and polyglycerol fatty acid esters.

[0058] Example 3

[0059] A special stirring reaction kettle for preparing silybin phospholipid complex, as Figures 1 - 7As shown in the figure, it includes a mounting frame 1, a kettle 2, a collection basin 3, a main pipe 31, an electric lifting push rod 32, a housing 4, an electric rotating shaft 41, a rotating disk 42, a shearing fan blade 43, a grinding block 44, a retaining ring 5 and a compression spring 53; the mounting frame 1 is provided with the kettle 2; a drain pipe 21 is connected to the inner bottom of the kettle 2; a collection basin 3 is inserted into the inner bottom of the kettle 2, and the collection basin 3 initially blocks the drain pipe 21; a cavity structure 301 is provided on the lower side inside the collection basin 3; the bottom of the kettle 2 is slidably connected with the main pipe 31; an electric control valve is arranged inside the main pipe 31; the main pipe 31 is connected to the cavity structure 301 of the collection basin 3; a plurality of suction hole structures 302 communicating with the cavity structure 301 are provided inside the collection basin 3; an annular vertical groove structure 303 communicating with all the suction hole structures 302 is provided on the inner bottom of the collection basin 3; the mounting frame 1 is provided with the electric lifting push rod 32; the telescopic end of the electric lifting push rod 32 is fixedly connected to the main pipe 31; the housing 4 is fixedly connected inside the kettle 2; a plurality of side hole structures 401 penetrating inside and outside are provided on the side wall of the housing 4; the electric rotating shaft 41 is rotatably connected between the kettle 2 and the housing 4; the lower end of the electric rotating shaft 41 is fixedly connected with the rotating disk 42, and the rotating disk 42 is located inside the housing 4; a plurality of shearing fan blades 43 are fixedly connected to the lower side of the rotating disk 42; the high-speed shearing emulsifying head is jointly composed of the housing 4, the electric rotating shaft 41, the rotating disk 42 and the shearing fan blades 43; a grinding block 44 is fixedly connected to the bottom of each shearing fan blade 43; the retaining ring 5 is slidably connected inside the collection basin 3; a compression spring 53 is jointly fixedly connected between the retaining ring 5 and the collection basin 3; the retaining ring 5 blocks the inlet ends of all the suction hole structures 302; a plurality of air guide hole structures 501 are provided on the retaining ring 5; a first screen 51 is fixedly connected to each air guide hole structure 501 of the retaining ring 5; a plurality of drain hole structures 502 are provided on the bottom of the retaining ring 5; a second screen 52 is fixedly connected to each drain hole structure 502 of the retaining ring 5.

[0060] The operation steps for producing the silymarin phospholipid complex described in Example 1 using the stirring reactor of the present invention are as follows.

[0061] First, the operator introduces the composite solution in step 4 and the pure water in step 5 described in Example 1 into the kettle 2 through the pipeline according to the specified ratio, and the electric shaft 41 drives the rotating disk 42 and the shear blades 43 in the cover 4 to rotate at a high speed, so that the high-speed shear emulsification head running at high speed can fully mix and emulsify the composite solution and the pure water in the kettle 2, so that the two liquids are mixed more evenly. In this process, the continuously rotating shear blades 43 will also stir the liquid in the kettle 2, so that the two liquids will continue to precipitate during the stirring and mixing process. After the precipitation, the liquid in the kettle 2 gradually becomes a waste solvent. After the stirring and mixing of the two liquids is completed, the high-speed shear emulsification head stops running, so that the precipitate precipitated in the kettle 2 continues to settle and gather in the collection basin 3 in a static state. Since the electric control valve built into the main pipeline 31 is initially in a closed state, the solvent in the kettle 2 will not be discharged from the main pipeline 31 through the drainage hole structure 502 of the retaining ring 5, thereby completing the unified collection of the precipitate.

[0062] Afterwards, the operator connects the drain pipe 21 and the main pipe 31 to an external waste liquid recovery device, and then the operator controls the electric lifting push rod 32 to push the main pipe 31 to drive the collection basin 3 to move upward, and at the same time, the built-in electric control valve of the main pipe 31 is switched to the open state. During this process, part of the solvent in the kettle 2 will be discharged outward along the second screen 52 of the retaining ring 5, the drain hole structure 502, the annular vertical groove structure 303 of the collection basin 3, the suction hole structure 302, the cavity structure 301 and the main pipe 31 to the external waste liquid recovery device. At the same time, the remaining solvent in the kettle 2 is directly discharged outward through the drain pipe 21 to the external waste liquid recovery device, so as to realize the unified recovery and treatment of the remaining solvent in the kettle 2.

[0063] After the solvent recovery process is completed, the operator controls the electric lifting push rod 32 again to push the main pipe 31 to continue to drive the collection basin 3 to move upward. Figure 8As shown, until the collection basin 3 is covered upward on the housing 4, and the stationary housing 4 pushes the retaining ring 5 in the upwardly moving collection basin 3 to drive the compression of the compression spring 53, so that the second screen 52 and the liquid discharge hole structure 502 at the bottom of the retaining ring 5 are inserted downward into the annular vertical groove structure 303 of the collection basin 3. At this time, each air guide hole structure 501 of the retaining ring 5 is respectively connected to the corresponding suction hole structure 302 of the collection basin 3, and the operator disconnects the main pipeline 31 from the external waste liquid recovery device and connects the main pipeline 31 to the suction collection device. The external suction collection device performs suction work on the main pipeline 31, so that under the suction action, external air flows into the collection basin 3 along the side hole structure 401 of the housing 4, and then successively flows through the air guide hole structure 501 of the retaining ring 5, the suction hole structure 302 of the collection basin 3, the cavity structure 301 and the main pipeline 31 and is sucked away by the external suction collection device, realizing that during the continuous flow of external air through the inside of the collection basin 3, the precipitate collected in the collection basin 3 is dried. Since the air guide hole structure 501 is more densely distributed than the liquid discharge hole structure 502, more airflows can evenly flow through the collection basin 3, improving the drying efficiency and drying uniformity of the precipitate in the collection basin 3.

[0064] At the same time, the electric rotating shaft 41 drives the rotating disk 42 and the shearing fan blades 43 in the housing 4 to rotate slowly. When the shearing fan blades 43 drive the grinding block 44 to rotate, the grinding block 44 crushes the precipitate collected in the collection basin 3. At the same time, the dried precipitate will be blown towards the first screen 51 of the retaining ring 5 along with the airflow flowing in the collection basin 3. Only the precipitate with qualified size after crushing can pass through the first screen 51 and be sucked away by the external suction collection device along with the airflow. At the same time, the brush 45 rotating with the grinding block 44 timely brushes off the precipitate with unqualified size blocked on the first screen 51, so that the precipitate with unqualified size is crushed again by the grinding block 44 until the precipitate is crushed to a qualified size and can pass through the first screen 51 and be sucked away by the external suction collection device along with the airflow, realizing that the precipitate collected in the collection basin 3 is successively dried and crushed and uniformly collected into the external suction collection device.

[0065] In summary, the stirring reaction kettle of the present invention has three functions of successively completing the stirring and mixing treatment of two kinds of liquid materials, the filtration treatment of precipitate and solvent, and the drying and crushing treatment of precipitate, realizing that one machine completes the various treatments in Step 6 and Step 7 described in Embodiment 1, saving the time and equipment operation cost consumed by material transfer in each treatment step, and greatly improving the production efficiency of silymarin phospholipid complex.

[0066] Embodiment 4

[0067] As Figures 1 - 7As shown, on the basis of Embodiment 3, an air delivery pipe 6 is fixedly connected inside the kettle 2 of this embodiment; the outlet end of the air delivery pipe 6 is connected to the internal space of the housing 4; a ring of retaining ring structures 421 is provided on the rotating disk 42; a number of air vent structures 4201 penetrating in the up and down direction are formed on the rotating disk 42; a brush 45 is fixedly connected to each grinding block 44 on the side facing the bottom of the housing 4; a feeding branch pipe 61 is connected to the air delivery pipe 6.

[0068] In the working steps of drying and pulverizing the precipitate, the operator externally connects the air delivery pipe 6 to a hot air flow conveying device, and externally connects the feeding branch pipe 61 to a fluidizing agent blowing device. The externally connected hot air flow conveying device blows hot air flow into the housing 4 along the air delivery pipe 6. After being intercepted by the retaining ring structure 421, the hot air flow diffuses in all directions towards the top of the rotating disk 42, so that the hot air flow uniformly blows down from each air vent structure 4201 of the rotating disk 42 into the collection basin 3, realizing uniform heat drying treatment of the precipitate collected in the collection basin 3 by the hot air flow, accelerating the drying efficiency of the precipitate. At the same time, the externally connected fluidizing agent blowing device blows the fluidizing agent into the air delivery pipe 6. The fluidizing agent is blown into the collection basin 3 along the air delivery pipe 6 with the hot air flow, so that the fluidizing agent is uniformly dispersed in each area of the collection basin 3 with the hot air flow. And during the process of the grinding block 44 rotating and pulverizing the precipitate in the collection basin 3, the grinding block 44 grinds and mixes the fluidizing agent and the precipitate in the collection basin 3 together to improve the flow effect of the precipitate. Finally, the pulverized fluidizing agent and precipitate are sucked away by an externally connected suction collection device with the air flow.

[0069] Although the present disclosure has been described only with respect to a limited number of embodiments, those skilled in the art who benefit from the present disclosure will understand that various other embodiments can be designed without departing from the scope of the present invention. Therefore, the scope of the present invention should be limited only by the appended claims.

Claims

1. A special stirring reactor for the preparation of silymarin phospholipid complex, characterized in that: It includes a mounting frame (1); a kettle (2) is mounted on the mounting frame (1); a drain pipe (21) is connected inside the kettle (2); a collection basin (3) is inserted into the kettle (2), and the collection basin (3) initially blocks the drain pipe (21); an electric control valve is built in the main pipe (31); a cavity structure (301) is formed inside the collection basin (3); the bottom of the kettle (2) is slidably connected to the main pipe (31); the main pipe (31) is connected to the cavity structure (301) of the collection basin (3); a number of suction hole structures (302) connected to the cavity structure (301) are formed inside the collection basin (3); an annular vertical groove structure (303) connected to the suction hole structure (302) is formed inside the collection basin (3); an electric lifting push rod (32) is mounted on the mounting frame (1); the telescopic end of the electric lifting push rod (32) is fixedly connected to the main pipe (31); a housing (4) is fixedly connected inside the kettle (2); a number of side hole structures (401) are formed in the housing (4); an electric rotating shaft (41) is rotatably connected between the kettle (2) and the housing (4); the electric rotating shaft (41) is fixedly connected to a rotating disk (42), and the rotating disk (42) is located inside the housing (4); a number of shearing fan blades (43) are fixedly connected to the lower side of the rotating disk (42); a grinding block (44) is fixedly connected to the shearing fan blade (43); a retaining ring (5) for blocking the suction hole structure (302) is slidably connected inside the collection basin (3); a compression spring (53) is fixedly connected between the retaining ring (5) and the collection basin (3); a number of air guide hole structures (501) are formed in the retaining ring (5); a first screen (51) is fixedly connected to the air guide hole structure (501) of the retaining ring (5); a number of drain hole structures (502) are formed at the bottom of the retaining ring (5); a brush (45) is fixedly connected to the grinding block (44).

2. The special stirring reactor for preparing silymarin phospholipid complex according to claim 1, characterized in that: A second screen (52) is fixedly connected to the drain hole structure (502) of the retaining ring (5).

3. The special stirring reactor for preparing silymarin phospholipid complex according to claim 1, characterized in that: An air delivery pipe (6) is fixedly connected inside the kettle (2); the air delivery pipe (6) is connected to the housing (4).

4. The special stirring reactor for preparing silymarin phospholipid complex according to claim 3, characterized in that: A retaining ring structure (421) is provided on the rotating disk (42); a ventilation hole structure (4201) is formed in the rotating disk (42).

5. A special stirring reactor for preparing silymarin phospholipid complex according to claim 3, characterized in that: A feeding branch pipe (61) is connected to the air delivery pipe (6).

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