A dressing with antibacterial function and preparation method thereof

Abstract

The present invention relates to the technical field of dressings, and in particular to a dressing with antibacterial function and a preparation method thereof. The dressing with antibacterial function comprises a dressing contact layer, a dressing water absorption layer and a spiral skeleton for connecting the dressing contact layer and the dressing water absorption layer, wherein the spiral skeleton is embedded in the dressing contact layer and the dressing water absorption layer. The dressing with antibacterial function proposed by the present invention comprises a dressing contact layer, a dressing water absorption layer and a spiral skeleton, wherein the dressing contact layer and the lower end of the spiral skeleton are in contact with a wound surface, and exudate can be drained to the dressing water absorption layer through the spiral skeleton, so that the water content in the dressing contact layer is avoided to be too high, and the active components are prevented from being diluted or lost, so that the active components such as chitosan and ε-polylysine in the dressing contact layer are in a higher concentration range, thereby improving the bactericidal effect and accelerating the healing time.

Description

Technical Field

[0001] The present invention relates to the technical field of dressings, and in particular to a dressing with antibacterial function and a preparation method thereof. Background Art

[0002] Dressings usually refer to medical materials that temporarily cover wounds and provide protection for them. When tissues are damaged by the outside world, it will cause infection caused by decreased body fluid loss and decreased immunity, which will cause various complications. Therefore, choosing the right dressing when tissues are damaged can not only effectively control the bleeding of the wound, but also prevent infection and absorb secretions, thereby promoting the healing process of the wound and greatly shortening the healing time of the wound.

[0003] The existing dressing types mainly include two categories: fiber dressings and membrane dressings. For fiber dressings, there are two main preparation methods. One is to co-spin the active component with the fiber, and the active component is directly compounded inside the fiber. The dressing prepared in this way releases the active component relatively slowly, which has a certain impact on the treatment. The second is to first prepare a fiber matrix, and then attach the active component to the surface of the fiber matrix by soaking or spraying. The dressing prepared in this way releases the active component quickly, but for wounds with more exudate, the active component will be diluted or washed away by the exudate, affecting the treatment effect. For membrane dressings, their air permeability is inferior to that of fiber dressings, and for wounds with more exudate, after the dressing absorbs a large amount of exudate, the air permeability will further decrease, and the concentration of the active component will decrease, affecting the recovery of the wound.

[0004] Therefore, we propose a dressing with antibacterial function and a preparation method thereof to solve the above problems. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a dressing with antibacterial function and a preparation method thereof.

[0006] A dressing with antibacterial function, comprising a dressing contact layer, a dressing water absorption layer and a spiral skeleton for connecting the dressing contact layer and the dressing water absorption layer, wherein the spiral skeleton is embedded in the dressing contact layer and the dressing water absorption layer;

[0007] The dressing contact layer is made of the following raw materials in parts by weight: 20-30 parts of chitosan, 4-8 parts of citric acid, 1-4 parts of sodium carboxymethyl cellulose, 20-30 parts of vaseline, 5-8 parts of cyclodextrin, 4-6 parts of ε-polylysine and 40-60 parts of water;

[0008] The water-absorbing layer of the dressing is made of the following raw materials in parts by weight: 40-55 parts of sodium alginate, 20-25 parts of gelatin, 10-15 parts of glycerol, 2-4 parts of biguanide antibacterial agent and 15-25 parts of water;

[0009] The spiral skeleton is made of a polypropylene fiber composite.

[0010] Preferably, the preparation method of the spiral skeleton comprises the following steps: step 1, spirally winding polypropylene fiber on a cylindrical template; step 2, immersing the template and the polypropylene fiber in a saturated calcium hydroxide solution for 5min-10min, and then drying the solution under a carbon dioxide gas flow, and repeating the process 2-8 times; step 3, immersing the polypropylene fiber loaded with calcium carbonate in step 2 and the template in a quaternary ammonium salt antibacterial agent solution for 10min-30min, and then drying the solution; step 4, performing demoulding to obtain a spiral polypropylene fiber composite, i.e., the spiral skeleton.

[0011] Preferably, in step 2, the drying temperature is 60° C.-80° C., and the amount of carbon dioxide corresponding to each template is 0.5 L / min-2 L / min.

[0012] Preferably, the concentration of the solute in the quaternary ammonium salt antibacterial agent solution is 0.01 mol / L-0.1 mol / L, and the quaternary ammonium salt antibacterial agent is one of benzalkonium chloride, hexaalkyldimethylbenzyl ammonium chloride and methamphetamine chloride.

[0013] Preferably, the diameter of the template is 2mm-5mm, and the template is an inflatable and deflable air bag.

[0014] Preferably, in step 4, during demoulding, the compressed gas inside the airbag is released to perform demoulding.

[0015] Preferably, the biguanide antibacterial agent is one of polyhexamethylene biguanide and polyaminopropyl biguanide.

[0016] Preferably, the lowermost end of the spiral skeleton is flush with the lowermost end of the dressing contact layer, the uppermost end of the spiral skeleton is located below the uppermost end of the dressing water absorption layer, and the minimum straight-line distance between adjacent spiral skeletons is 2mm-5mm.

[0017] Preferably, a method for preparing a dressing with antibacterial function comprises the following steps:

[0018] S1, weigh 20-30 parts of chitosan, 4-8 parts of citric acid, 1-4 parts of sodium carboxymethyl cellulose, 20-30 parts of vaseline, 5-8 parts of cyclodextrin, 4-6 parts of ε-polylysine and 40-60 parts of water, mix them evenly, pour them into a molding mold A, then put the spiral skeleton in, and perform freeze-drying to obtain a dressing contact layer equipped with the spiral skeleton;

[0019] S2. Place the dressing contact layer equipped with a spiral skeleton prepared in S1 into a molding mold B, weigh 40-55 parts of sodium alginate, 20-25 parts of gelatin, 10-15 parts of glycerol, 2-4 parts of biguanide antibacterial agent and 15-25 parts of water, mix well, pour into the molding mold B, and quickly perform freeze-drying to obtain a dressing with antibacterial function.

[0020] Preferably, in step S2, after the freeze-drying process is completed, the dressing is cut, sterilized and packaged.

[0021] The beneficial effects of the present invention are:

[0022] 1. The dressing with antibacterial function proposed in the present invention comprises a dressing contact layer, a dressing water absorption layer and a spiral skeleton, wherein the dressing contact layer and the lower end of the spiral skeleton are in contact with the wound surface, and the exudate can be drained to the dressing water absorption layer through the spiral skeleton, so as to avoid excessive moisture content in the dressing contact layer and prevent the active components from being diluted or lost, so that the active components such as chitosan and ε-polylysine in the dressing contact layer are in a higher concentration range, thereby improving the bactericidal effect and accelerating the healing time.

[0023] 2. The dressing with antibacterial function proposed by the present invention comprises citric acid in the raw materials for preparing the dressing contact layer, and calcium carbonate in the spiral skeleton. Calcium citrate is generated by the reaction of citric acid and calcium carbonate, and the part of the spiral skeleton embedded in the dressing contact layer is softened to improve the overall comfort of the dressing. On the other hand, the generated calcium citrate has a certain hemostatic function, and can shorten the healing time of the wound by combining with other components. The upper end of the spiral skeleton can increase the strength of the dressing water absorption layer. After the dressing water absorption layer absorbs water, the dressing water absorption layer can still maintain a certain strength.

[0024] 3. In the dressing with antibacterial function proposed by the present invention, the lowermost end of the spiral skeleton is flush with the lowermost end of the dressing contact layer, and the end of the spiral skeleton is in contact with the outside air, so that the dressing has a certain breathable effect, which is beneficial to the patient's recovery.

[0025] 4. In the dressing with antibacterial function proposed by the present invention, the lowermost end of the spiral skeleton is flush with the lowermost end of the dressing contact layer, and the bactericidal components carried on the spiral skeleton can further improve the antibacterial effect of the dressing. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of the cross-sectional structure of a dressing with antibacterial function proposed by the present invention.

[0027] In the figure: 1 dressing contact layer, 2 spiral skeleton, 3 dressing water absorption layer. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0029] In the following embodiments, the experimental methods or test methods are conventional methods unless otherwise specified; reagents and materials are obtained from conventional commercial channels or prepared by conventional methods unless otherwise specified, wherein chitosan, citric acid, sodium carboxymethyl cellulose, vaseline, cyclodextrin, ε-polylysine, sodium alginate, gelatin, glycerol, calcium hydroxide, polyhexamethylene biguanide, polyaminopropyl biguanide, benzalkonium chloride, hexaalkyldimethylbenzyl ammonium chloride, and methamphetamine chloride are purchased from Sinopharm Chemical Reagent Co., Ltd.; carbon dioxide gas is purchased from Wuxi Xixi Gas Co., Ltd., and polypropylene fiber is the DTY fine denier polypropylene 30D series of Jiangsu Xinzhanjiang Fiber Technology Co., Ltd.

[0030] like Figure 1 As shown, a dressing with antibacterial function includes a dressing contact layer 1, a dressing water absorption layer 3 and a spiral skeleton 2 for connecting the dressing contact layer 1 and the dressing water absorption layer 3, and the spiral skeleton 2 is embedded in the dressing contact layer 1 and the dressing water absorption layer 3.

[0031] In Example 1,

[0032] The dressing contact layer 1 is made of the following raw materials in parts by weight: 20 parts of chitosan, 4 parts of citric acid, 1 part of sodium carboxymethyl cellulose, 20 parts of vaseline, 5 parts of cyclodextrin, 4 parts of ε-polylysine and 40 parts of water;

[0033] The water-absorbing layer 3 of the dressing is made of the following raw materials in parts by weight: 40 parts of sodium alginate, 20 parts of gelatin, 10 parts of glycerol, 2 parts of biguanide antibacterial agent and 15 parts of water;

[0034] The spiral skeleton 2 is made of a polypropylene fiber composite.

[0035] The preparation method of the spiral skeleton 2 comprises the following steps: step 1, spirally winding polypropylene fibers on a cylindrical template; step 2, immersing the template and the polypropylene fibers in a saturated calcium hydroxide solution for 5 minutes, and drying them under a carbon dioxide gas flow after completion, and repeating twice; step 3, immersing the polypropylene fibers loaded with calcium carbonate in step 2 and the template in a quaternary ammonium salt antibacterial agent solution for 10 minutes, and drying them after completion; step 4, performing demolding to obtain a spiral polypropylene fiber composite, namely the spiral skeleton 2.

[0036] In step 2, the drying temperature is 60° C., and the amount of carbon dioxide corresponding to each template is 0.5 L / min.

[0037] The concentration of the solute in the quaternary ammonium salt antibacterial agent solution is: 0.01 mol / L, and the quaternary ammonium salt antibacterial agent is hexaalkyldimethylbenzyl ammonium chloride.

[0038] The diameter of the template is 2 mm, and the template is an inflatable and deflable air bag.

[0039] In step 4, during demoulding, the compressed gas inside the airbag is released to perform demoulding.

[0040] The biguanide antibacterial agent is polyhexamethylene biguanide.

[0041] The lowermost end of the spiral skeleton 2 is flush with the lowermost end of the dressing contact layer 1, and the uppermost end of the spiral skeleton 2 is located below the uppermost end of the dressing water absorption layer 3. The minimum straight-line distance between adjacent spiral skeletons 2 is 2 mm, and the spiral skeletons 2 are parallel to each other.

[0042] A method for preparing a dressing with antibacterial function comprises the following steps:

[0043] S1, weigh 20 parts of chitosan, 4 parts of citric acid, 1 part of sodium carboxymethyl cellulose, 20 parts of vaseline, 5 parts of cyclodextrin, 4 parts of ε-polylysine and 40 parts of water, mix them evenly, pour them into a molding mold A, then put the spiral skeleton 2 in, and perform freeze-drying to obtain a dressing contact layer 1 equipped with the spiral skeleton 2;

[0044] S2. Place the dressing contact layer 1 equipped with the spiral skeleton 2 prepared in S1 into a molding mold B, weigh 40 parts of sodium alginate, 20 parts of gelatin, 10 parts of glycerol, 2 parts of biguanide antibacterial agent and 15 parts of water, mix them evenly, pour them into the molding mold B, and quickly perform freeze-drying to obtain a dressing with antibacterial function.

[0045] In step S2, after the freeze-drying process is completed, the dressing is cut, sterilized and packaged.

[0046] In Example 2,

[0047] The dressing contact layer 1 is made of the following raw materials in parts by weight: 30 parts of chitosan, 8 parts of citric acid, 4 parts of sodium carboxymethyl cellulose, 30 parts of vaseline, 8 parts of cyclodextrin, 6 parts of ε-polylysine and 60 parts of water;

[0048] The water-absorbing layer 3 of the dressing is made of the following raw materials in parts by weight: 55 parts of sodium alginate, 25 parts of gelatin, 15 parts of glycerol, 4 parts of biguanide antibacterial agent and 25 parts of water;

[0049] The spiral skeleton 2 is made of a polypropylene fiber composite.

[0050] The preparation method of the spiral skeleton 2 comprises the following steps: step 1, spirally winding polypropylene fibers on a cylindrical template; step 2, immersing the template and the polypropylene fibers in a saturated calcium hydroxide solution for 10 minutes, and drying them under a carbon dioxide gas flow after completion, and repeating 8 times; step 3, immersing the polypropylene fibers loaded with calcium carbonate in step 2 and the template in a quaternary ammonium salt antibacterial agent solution for 30 minutes, and drying them after completion; step 4, performing demolding to obtain a spiral polypropylene fiber composite, namely the spiral skeleton 2.

[0051] In step 2, the drying temperature is 80° C., and the amount of carbon dioxide corresponding to each template is 2 L / min.

[0052] The concentration of the solute in the quaternary ammonium salt antibacterial agent solution is: 0.1 mol / L, and the quaternary ammonium salt antibacterial agent is benzalkonium chloride.

[0053] The diameter of the template is 5 mm, and the template is an inflatable and deflable air bag.

[0054] In step 4, during demoulding, the compressed gas inside the airbag is released to perform demoulding.

[0055] The biguanide antibacterial agent is polyhexamethylene biguanide.

[0056] The lowermost end of the spiral skeleton 2 is flush with the lowermost end of the dressing contact layer 1, and the uppermost end of the spiral skeleton 2 is located below the uppermost end of the dressing water absorption layer 3. The minimum straight-line distance between adjacent spiral skeletons 2 is 5 mm, and the spiral skeletons 2 are parallel to each other.

[0057] A method for preparing a dressing with antibacterial function comprises the following steps:

[0058] S1, weigh 30 parts of chitosan, 8 parts of citric acid, 4 parts of sodium carboxymethyl cellulose, 30 parts of vaseline, 8 parts of cyclodextrin, 6 parts of ε-polylysine and 60 parts of water, mix them evenly, pour them into a molding mold A, then put the spiral skeleton 2 in, and perform freeze-drying to obtain a dressing contact layer 1 equipped with the spiral skeleton 2;

[0059] S2. Place the dressing contact layer 1 equipped with the spiral skeleton 2 prepared in S1 into a molding mold B, weigh 55 parts of sodium alginate, 25 parts of gelatin, 15 parts of glycerol, 4 parts of biguanide antibacterial agent and 25 parts of water, mix them evenly, pour them into the molding mold B, and quickly perform freeze-drying to obtain a dressing with antibacterial function.

[0060] In step S2, after the freeze-drying process is completed, the dressing is cut, sterilized and packaged.

[0061] In Example 3,

[0062] The dressing contact layer 1 is made of the following raw materials in parts by weight: 25 parts of chitosan, 6 parts of citric acid, 2 parts of sodium carboxymethyl cellulose, 25 parts of vaseline, 7 parts of cyclodextrin, 5 parts of ε-polylysine and 50 parts of water;

[0063] The water-absorbing layer 3 of the dressing is made of the following raw materials in parts by weight: 45 parts of sodium alginate, 25 parts of gelatin, 12 parts of glycerol, 3 parts of biguanide antibacterial agent and 20 parts of water;

[0064] The spiral skeleton 2 is made of a polypropylene fiber composite.

[0065] The preparation method of the spiral skeleton 2 comprises the following steps: step 1, spirally winding polypropylene fibers on a cylindrical template; step 2, immersing the template and the polypropylene fibers in a saturated calcium hydroxide solution for 8 minutes, and drying them under a carbon dioxide gas flow after completion, and repeating 6 times; step 3, immersing the polypropylene fibers loaded with calcium carbonate in step 2 and the template in a quaternary ammonium salt antibacterial agent solution for 20 minutes, and drying them after completion; step 4, performing demolding to obtain a spiral polypropylene fiber composite, namely the spiral skeleton 2.

[0066] In step 2, the drying temperature is 70° C., and the amount of carbon dioxide corresponding to each template is 1 L / min.

[0067] The concentration of the solute in the quaternary ammonium salt antibacterial agent solution is: 0.05 mol / L, and the quaternary ammonium salt antibacterial agent is mithraconium chloride.

[0068] The diameter of the template is 4 mm, and the template is an inflatable and deflable air bag.

[0069] In step 4, during demoulding, the compressed gas inside the airbag is released to perform demoulding.

[0070] The biguanide antibacterial agent is polyaminopropyl biguanide.

[0071] The lowermost end of the spiral skeleton 2 is flush with the lowermost end of the dressing contact layer 1, and the uppermost end of the spiral skeleton 2 is located below the uppermost end of the dressing water absorption layer 3. The minimum straight-line distance between adjacent spiral skeletons 2 is 4 mm, and the spiral skeletons 2 are parallel to each other.

[0072] A method for preparing a dressing with antibacterial function comprises the following steps:

[0073] S1, weigh 25 parts of chitosan, 6 parts of citric acid, 2 parts of sodium carboxymethyl cellulose, 25 parts of vaseline, 7 parts of cyclodextrin, 5 parts of ε-polylysine and 50 parts of water, mix them evenly, pour them into a molding mold A, then put the spiral skeleton in, and perform freeze-drying to obtain a dressing contact layer 1 equipped with a spiral skeleton 2;

[0074] S2. Place the dressing contact layer 1 equipped with the spiral skeleton 2 prepared in S1 into a molding mold B, weigh 45 parts of sodium alginate, 25 parts of gelatin, 12 parts of glycerol, 3 parts of biguanide antibacterial agent and 20 parts of water, mix them evenly, pour them into the molding mold B, and quickly perform freeze-drying to obtain a dressing with antibacterial function.

[0075] In step S2, after the freeze-drying process is completed, the dressing is cut, sterilized and packaged.

[0076] In Examples 1-3, molding mold A and molding mold B were used in the process of preparing the dressing with antibacterial function. During the production process, one mold can be used to replace molding mold A and molding mold B, that is, the raw materials of the dressing contact layer 1 are first added to the first scale, and after the dressing contact layer 1 is shaped, the subsequent raw materials of the dressing water absorption layer 3 are continued to be added.

[0077] In Comparative Example 1, compared with Example 1, citric acid was not added to the dressing contact layer, and the rest was the same as Example 1.

[0078] In Comparative Example 2, compared with Example 1, the method for preparing the spiral skeleton 2 is different. In Comparative Example 2, the method for preparing the spiral skeleton 2 includes the following steps: Step 1, spirally winding the polypropylene fiber on a cylindrical template; Step 2, soaking the polypropylene fiber and the template in a quaternary ammonium salt antibacterial agent solution for 10 minutes, and then drying the solution; Step 3, demolding the solution to obtain a spiral polypropylene fiber composite, i.e., the spiral skeleton 2. The rest of the process is the same as that in Example 1.

[0079] In Comparative Example 3, compared with Example 1, the dressing only includes a dressing contact layer 1 and a dressing water absorption layer 3, but does not include a spiral skeleton 2, and the rest of the parts are the same as those of Example 1.

[0080] The performance of the dressings prepared in Examples 1-3 and Comparative Examples 1-3 was tested.

[0081] 1. Water absorption performance test

[0082] The dressings of Examples 1-3 and Comparative Examples 1-3 of the present invention were tested according to GB / T22905-2008 to test their water absorption and water retention. The results are shown in Table 1.

[0083] Table 1

[0084] Water absorption rate (g / g) Water retention rate (g / g) Example 1 72 41 Example 2 78 43 Example 3 83 46 Comparative Example 1 73 41 Comparative Example 2 66 38 Comparative Example 3 59 32

[0085] As can be seen from Table 1, the dressings prepared in Examples 1-3 have excellent water absorption and water retention properties. In Comparative Example 1, citric acid is not added to the dressing contact layer 1, and its water absorption and water retention properties are close to those of Example 1; in Comparative Example 2, there is no calcium carbonate on the spiral skeleton 2, resulting in low strength of the spiral skeleton 2, and the lower end of the spiral skeleton 2 is not flush with the lowermost end of the dressing contact layer 1. The water in the dressing contact layer 1 cannot be discharged in time, and the water absorption and water retention properties are reduced; in Comparative Example 3, the dressing only includes the dressing contact layer 1 and the dressing water absorption layer 3, but does not include the spiral skeleton 2, that is, lacks the biguanide antibacterial agent, the water in the dressing contact layer 1 is slowly discharged, and the water absorption and water retention properties are significantly reduced.

[0086] 2. In vitro antibacterial performance test

[0087] Common wound bacteria, Staphylococcus aureus, Escherichia coli and Streptococcus pyogenes, were used as experimental bacteria. 0.5 ml of bacterial solution (concentration of 10 5 ~10 6 CFU / ml) was dripped on the dressing samples of Examples 1-3 and Comparative Examples 1-3, and the sterilized cover sheets were picked up with sterilized tweezers and covered on the samples respectively, spread flat without bubbles, so that the bacteria evenly contacted the samples, placed in a sterilized plate, and cultured at (37±1)°C and relative humidity>90% for 24 hours, then taken out, 20ml of washing solution was added respectively, and the samples and coverslips were repeatedly washed, and after being fully shaken, the washing solution was inoculated in nutrient agar medium, and after being cultured at (37±1)°C for 24 hours, the live bacteria were counted. The antibacterial rates of Examples 1-3 and Comparative Examples 1-3 were calculated based on the colony counts of the blank group, and the test results are shown in Table 2.

[0088] Table 2

[0089]

[0090] As can be seen from Table 2, the dressing of the present application has a good in vitro antibacterial effect, and the antibacterial rate of Staphylococcus aureus, Escherichia coli, and Streptococcus pyogenes can reach more than 98%, and the antibacterial effect is significant. In Comparative Example 1, citric acid is not added to the dressing contact layer 1, and its antibacterial performance is close to that of Example 1; in Comparative Example 2, there is no calcium carbonate on the spiral skeleton 2, resulting in low strength of the spiral skeleton 2, and the lower end of the spiral skeleton 2 is not flush with the lowermost end of the dressing contact layer 1, and the antibacterial performance is slightly reduced; in Comparative Example 3, the dressing only includes the dressing contact layer 1 and the dressing water absorption layer 3, but does not include the spiral skeleton 2, that is, lacks the biguanide antibacterial agent, resulting in a significant decrease in the antibacterial performance of the dressing.

[0091] 3. Rat Experiment

[0092] 21 male SD rats weighing 200 g were divided into 7 groups. Secondary burn wounds of 1.5 cm×1.5 cm were made on the backs of the rats, and lactated Ringer's solution was injected to help them recover. The wound repair dressings of Examples 1 to 3 and Comparative Examples 1 to 3, as well as commercially available vaseline gauze were applied as a control group, and the wound healing was observed and the healing time was recorded. The experimental results are shown in Table 3.

[0093] Table 3

[0094] Wound healing time (d) Example 1 17 Example 2 15 Example 3 15 Comparative Example 1 19 Comparative Example 2 23 Comparative Example 3 25 Control group 27

[0095] As can be seen from Table 3, the wounds of rats healed faster with the dressings prepared in Examples 1-3, and the wounds could be completely healed within 17 days. In Comparative Example 1, no citric acid was added to the dressing contact layer 1, no calcium citrate was generated, and the healing time was prolonged; in Comparative Example 2, there was no calcium carbonate on the spiral skeleton 2, resulting in low strength of the spiral skeleton 2, the lower end of the spiral skeleton 2 was not flush with the lowest end of the dressing contact layer 1, the ability of the dressing contact layer 1 to discharge body fluids was reduced, and the healing time was significantly prolonged; in Comparative Example 3, the dressing only included the dressing contact layer 1 and the dressing water-absorbing layer 3, but did not include the spiral skeleton 2, the dressing contact layer 1 was difficult to discharge body fluids, and the healing time was close to that of the commercially available vaseline gauze, and the effect was not ideal.

[0096] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A dressing with antibacterial function, characterized in that: It comprises a dressing contact layer, a dressing water absorption layer and a spiral skeleton for connecting the dressing contact layer and the dressing water absorption layer, wherein the spiral skeleton is embedded in the dressing contact layer and the dressing water absorption layer; The dressing contact layer is made of the following raw materials in parts by weight: 20-30 parts of chitosan, 4-8 parts of citric acid, 1-4 parts of sodium carboxymethyl cellulose, 20-30 parts of vaseline, 5-8 parts of cyclodextrin, 4-6 parts of ε-polylysine and 40-60 parts of water; The water-absorbing layer of the dressing is made of the following raw materials in parts by weight: 40-55 parts of sodium alginate, 20-25 parts of gelatin, 10-15 parts of glycerol, 2-4 parts of biguanide antibacterial agent and 15-25 parts of water; The spiral skeleton is made of a polypropylene fiber composite; The preparation method of the spiral skeleton comprises the following steps: step 1, spirally winding polypropylene fibers on a cylindrical template; step 2, immersing the template and the polypropylene fibers in a saturated calcium hydroxide solution for 5-10 minutes, and then drying them under a carbon dioxide gas flow, and repeating the process 2-8 times; step 3, immersing the polypropylene fibers loaded with calcium carbonate in step 2 and the template in a quaternary ammonium salt antibacterial agent solution for 10-30 minutes, and then drying them; and step 4, performing demoulding to obtain a spiral polypropylene fiber composite, namely the spiral skeleton.

2. The dressing with antibacterial function according to claim 1, characterized in that: In step 2, the drying temperature is 60° C.-80° C., and the amount of carbon dioxide corresponding to each template is 0.5 L / min-2 L / min.

3. The dressing with antibacterial function according to claim 1, characterized in that: The concentration of the solute in the quaternary ammonium salt antibacterial agent solution is 0.01 mol / L-0.1 mol / L, and the quaternary ammonium salt antibacterial agent is one of benzalkonium chloride, hexaalkyldimethylbenzyl ammonium chloride and methamphetamine chloride.

4. The dressing with antibacterial function according to claim 1, characterized in that: The diameter of the template is 2mm-5mm, and the template is an inflatable and deflable air bag.

5. The dressing with antibacterial function according to claim 4, characterized in that: In step 4, during demoulding, the compressed gas inside the airbag is released to perform demoulding.

6. The dressing with antibacterial function according to claim 1, characterized in that: The biguanide antibacterial agent is one of polyhexamethylene biguanide and polyaminopropyl biguanide.

7. The dressing with antibacterial function according to claim 1, characterized in that: The lowermost end of the spiral skeleton is flush with the lowermost end of the dressing contact layer, the uppermost end of the spiral skeleton is located below the uppermost end of the dressing water absorption layer, and the minimum straight-line distance between adjacent spiral skeletons is 2mm-5mm.

8. A method for preparing a dressing with antibacterial function according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, weigh 20-30 parts of chitosan, 4-8 parts of citric acid, 1-4 parts of sodium carboxymethyl cellulose, 20-30 parts of vaseline, 5-8 parts of cyclodextrin, 4-6 parts of ε-polylysine and 40-60 parts of water, mix them evenly, pour them into a molding mold A, then put the spiral skeleton in, and perform freeze-drying to obtain a dressing contact layer equipped with the spiral skeleton; S2. Place the dressing contact layer equipped with a spiral skeleton prepared in S1 into a molding mold B, weigh 40-55 parts of sodium alginate, 20-25 parts of gelatin, 10-15 parts of glycerol, 2-4 parts of biguanide antibacterial agent and 15-25 parts of water, mix well, pour into the molding mold B, and quickly perform freeze-drying to obtain a dressing with antibacterial function.

9. The method for preparing a dressing with antibacterial function according to claim 8, characterized in that: In step S2, after the freeze-drying process is completed, the dressing is cut, sterilized and packaged.

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