An artificial cornea

By designing a removable mirror column structure and anti-glare coating, combined with a curved microlens array, the existing frequent artificial corneal replacement and glare problems are solved, achieving the effect of reducing trauma and cost and providing large field of view functions.

CN118892384BActive Publication Date: 2025-02-07SHANGHAI VISION SCIENCE ENGINEER MEDICAL EQUIPMENT CO LTD
View PDF 3 Cites 0 Cited by

Patent Information

Application Number
CN202411390561.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-10-08
Publication Date
2025-02-07
Estimated Expiration
2044-10-08

AI Technical Summary

Technical Problem

The existing artificial corneal is not adapted after transplantation due to changes in the patient's physiological conditions and needs to be replaced frequently, resulting in high costs and surgical trauma. At the same time, the existing corneal is difficult to provide a large field of view and effectively prevent glare.

Method used

An artificial cornea is designed, and its mirror column is divided into upper and lower sections. The two sections are removably connected. The inner concave and outer convex surfaces are arranged at the bottom of the upper section of the mirror column and the top of the lower section to cooperate with each other, and further coat the bottom of the upper section of the mirror column or the top of the lower section of the mirror column to prevent the Glare coating. A curved microlens array is provided on the top of the upper section of the mirror column, providing multifocal length function.

Benefits of technology

The detachable design of artificial cornea is realized, reducing the trauma and cost of the replacement process; through anti-glare coating and curved microlens array, glare phenomenon is reduced, providing a large field of view function, and improving the visual quality of patients.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN118892384B_ABST
    Figure CN118892384B_ABST
Patent Text Reader

Abstract

The invention discloses an artificial cornea, comprising a mirror column and a bracket. The mirror column comprises an upper mirror column section and a lower mirror column section. The upper mirror column section and the lower mirror column section are separate components. Both the upper mirror column section and the lower mirror column section are mounted on the bracket, and the upper mirror column section and the bracket are detachably connected. The upper mirror column section is arranged on the upper part of the lower mirror column section, and the bottom of the upper mirror column section abuts against the top of the lower mirror column section. The top of the upper mirror column section is an outer convex surface, and the bottom of the lower mirror column section is an inner concave surface.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The invention relates to medical devices, in particular to an artificial cornea. Background Art

[0002] An artificial cornea refers to a special refractive device made of artificial synthetic materials. It is used to replace the cloudy cornea that blocks the optical pathway of the eye after a disease, so that the patient can regain a certain degree of vision. However, after the existing artificial cornea is transplanted into the body of a corneal blind patient, as the patient's physiological condition changes, the original artificial cornea no longer adapts to the patient's physical condition. If a new artificial cornea is replaced, another surgery is required, which is costly and increases the surgical trauma and risks to the patient.

[0003] In addition, existing artificial corneas often cannot provide corneal blind patients with a larger field of view, making it difficult to achieve better results. Existing artificial corneas also have defects such as high manufacturing costs, complex processing, and uncontrollable curvature.

[0004] Although multifocal artificial corneas can provide a clear vision for both near and far objects, some patients may experience glare and other problems after surgery, which may be caused by the separated focus design. The separated focus design is prone to glare problems in multifocal artificial corneas, mainly because the separated focus design causes the light to refract and reflect at different focal points when passing through the lens column, which may lead to uneven distribution of light energy and scattering of light, thereby causing glare. Specifically, the separated focus design may cause the light to scatter when passing through the lens column, making the light entering the eye chaotic and causing glare. This scattered light may interfere with visual imaging and affect the patient's visual quality. Glare not only causes visual discomfort, but may also cause patients to feel dizziness, eye pain and other discomfort symptoms. For patients who require high visual quality (such as night drivers), glare problems may seriously affect their daily life and work.

[0005] Similarly, single-focal-length artificial corneas can also cause glare problems. The main reasons for the glare of single-focal-length artificial cornea lens columns are: (1) Light reflection: When light passes through the front and rear surfaces of the lens column, most of the light will pass through the lens column and reach the rear of the lens column. Some of the light will be reflected on the front and rear surfaces. These reflected lights may cause glare. (2) Mirror column design: The design characteristics of the lens column make its refractive power stronger in some directions and weaker in other directions. This uneven refractive power may cause complex reflection and refraction of light inside the lens, thus causing glare. Summary of the invention

[0006] To this end, the present invention provides an artificial cornea that can solve at least part of the above problems.

[0007] In order to achieve the purpose of the present invention, the following technical solutions are adopted:

[0008] An artificial cornea comprises a mirror column and a bracket, wherein: the mirror column comprises an upper mirror column section and a lower mirror column section, the upper mirror column section and the lower mirror column section are separate components, both of which are mounted on the bracket, and the upper mirror column section and the bracket are detachably connected; the upper mirror column section is arranged on the upper part of the lower mirror column section, the bottom of the upper mirror column section abuts against the top of the lower mirror column section; the top of the upper mirror column section is an outer convex surface, and the bottom of the lower mirror column section is an inner concave surface.

[0009] The artificial cornea, wherein: the bottom of the upper section of the mirror column is processed with an inner concave surface, and the top of the lower section of the mirror column is processed with an outer convex surface, and the inner concave surface and the outer convex surface cooperate with each other.

[0010] The artificial cornea, wherein: the upper section of the mirror column is coated with an anti-glare coating at its bottom, or the lower section of the mirror column is coated with an anti-glare layer at its top.

[0011] The artificial cornea, wherein: the upper section of the mirror column is coated with an anti-glare coating on its bottom concave surface, or the lower section of the mirror column is coated with an anti-glare layer on its top convex surface.

[0012] The artificial cornea, wherein: a mounting hole is provided at the center of the bracket, the mounting hole is provided with an internal thread, the lower outer wall of the upper section of the mirror column is processed with an external thread, the upper outer wall of the lower section of the mirror column is processed with an external thread, and the upper section of the mirror column and the lower section of the mirror column are respectively matched with the mounting hole thread of the bracket through their own external threads.

[0013] The artificial cornea, wherein: the outer convex surface and the inner concave surface are both spherical surfaces.

[0014] The artificial cornea, wherein: the outer convex surface of the top of the upper section of the mirror column is used as a base, and a curved microlens array is arranged on the base, and the curved microlens array includes multi-level microlens units.

[0015] The artificial cornea, wherein: the corresponding field of view focal points of each level of microlens units are focused on the same focal plane.

[0016] In the artificial cornea, the microlens units in the curved microlens array are arranged on a plurality of concentric circles, and the microlens units on the same concentric circle have the same size and shape, forming a primary microlens unit.

[0017] The artificial cornea, wherein: the diameter of the outer circle of microlens units is smaller than the diameter of the inner circle of microlens units. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Schematic diagram of the structure of artificial cornea;

[0019] Figure 2Schematic diagram of the structure of artificial cornea;

[0020] Figure 3 Schematic diagram of the mirror column structure;

[0021] Figure 4 is a schematic diagram of the support structure;

[0022] Figure 5 This is a schematic diagram of the multifocal artificial cornea structure;

[0023] Figure 6 This is a schematic diagram of the base structure of a multi-focal artificial cornea;

[0024] Figure 7 Schematic diagram of the model designed for the curved microlens array. DETAILED DESCRIPTION

[0025] The following is combined with Figure 1-7 , the specific implementation methods of the present invention are described in detail. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention. The implementation methods are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0026] "One embodiment" or "some embodiments" described in this specification means that one or more embodiments of the present invention include specific features, structures or characteristics described in conjunction with the embodiment. Therefore, in this specification, the terms "including", "comprising", "having" and their variations all mean "including but not limited to", unless otherwise specifically emphasized.

[0027] like Figure 1 , 2 As shown, Figure 2 Shown is Figure 1 After flipping 180 degrees, in one embodiment, the artificial cornea of ​​the present invention comprises a lens column 1 and a bracket 2, wherein the lens column 1 is mounted on the bracket 2. Figure 4 As shown, the center of the bracket 2 is provided with a mounting hole 6, the mounting hole 6 is provided with an internal thread, the mirror column 1 is provided with an external thread 5, the mirror column 1 is screwed into the mounting hole 6 of the bracket 2, and is installed on the bracket 2 through the threaded fit between the external thread 5 and the internal thread of the threaded mounting hole 6. The main body of the mirror column 1 is made of a transparent material (such as PMMA polymethyl methacrylate, etc.).

[0028] The upper and lower ends of the mirror column 1 are exposed outside the bracket 2. The top of the mirror column 1 is provided with an outer convex surface 3, and the bottom of the mirror column 1 is provided with an inner concave surface 10 corresponding thereto. Both the outer convex surface 3 and the inner concave surface 10 are spherical surfaces.

[0029] like Figure 2 As shown, the bracket 2 includes a first support ring 21 sleeved on the outside of the lens column 1, and a second support ring 22 arranged on the outside of the first support ring. The mounting hole 6 is arranged on the first support ring 21, located at the center of the first center support ring 21. A plurality of connecting rods 23 are arranged evenly between the first support ring 21 and the second support ring 22 and respectively connect the two. The bracket 2 can provide the required support medium and environment for the growth of tissue cells, thereby ensuring the implantation effect of the artificial cornea.

[0030] like Figure 3 As shown, the mirror column 1 includes a mirror column upper section 11 and a mirror column lower section 12, and the mirror column upper section 11 and the mirror column lower section 12 are two separate parts. The lower outer wall of the mirror column upper section 11 is processed with an external thread 8, and the upper outer wall of the mirror column lower section 12 is processed with an external thread 9. The mirror column upper section 11 and the mirror column lower section 12 are threadedly matched with the mounting hole 6 of the bracket 2 through their own external threads 8 and external threads 9, respectively. The mirror column upper section 11 is arranged on the upper part of the mirror column lower section 12, and the bottom of the mirror column upper section 11 is in contact with the top of the mirror column lower section 12. The top of the mirror column upper section 11 is an outer convex surface 3, and the bottom of the mirror column lower section 12 is an inner concave surface 10. The above-mentioned two-stage split structure of the mirror column 1 can be replaced by removing the mirror column upper section 11 and replacing it with a new mirror column upper section 11 when the artificial cornea needs to be replaced. It is not only convenient to operate, but also does not require surgery deep into the fundus, reducing surgical trauma and alleviating the pain of patients.

[0031] Furthermore, the bottom of the upper mirror column section 11 is processed with an inner concave surface, and correspondingly, the top of the lower mirror column section 12 is processed with an outer convex surface, and the shapes and sizes of the inner concave surface and the outer convex surface match each other, so that when the bottom of the upper mirror column section 11 and the top of the lower mirror column section 12 are in contact, the inner concave surface and the outer convex surface are in good contact. Preferably, the inner concave surface and the outer convex surface are spherical. By providing the inner concave surface and the outer convex surface that can match each other as above, the reflection of the light entering the mirror column 1 can be weakened, thereby reducing glare.

[0032] Furthermore, the concave surface at the bottom of the upper section 11 of the mirror column is coated with an anti-glare coating 7, which can be an ITO (indium tin oxide) coating. The bottom of the upper section 11 of the mirror column can be coated by dipping in an ethanol solution of indium tin oxide nanoparticles with a mass fraction of 25%, and the obtained film is cured in air at 130°C for 20 hours to obtain the anti-glare coating 7. The anti-glare coating 7 has a good anti-glare function. In addition, the present invention abandons the conventional method of setting the anti-glare coating 7 on the outer convex surface at the top of the mirror column 1, but arranges it in the concave surface at the bottom of the upper section 11 of the mirror column, which can prevent the anti-glare coating from being exposed to the outside of the eye and being easily eroded by external substances such as tears and face wash water, thereby extending the service life of the anti-glare coating. Similarly, the anti-glare coating 7 can also be set on the outer convex surface at the top of the lower section 12 of the mirror column.

[0033] Furthermore, in order to enable the patient to see both far and near, the present invention also provides a second embodiment, which relates to a multi-focal length artificial cornea.

[0034] like Figure 5-7 As shown, the multifocal artificial cornea of ​​the present invention, except for the structure related to multifocal length, the other structures of the multifocal artificial cornea are the same as those of the aforementioned artificial cornea.

[0035] The multifocal artificial cornea comprises a lens column 1 and a bracket 2, wherein the lens column 1 is mounted on the bracket 2. A mounting hole is provided at the center of the bracket 2, wherein the mounting hole is provided with an internal thread, and the lens column 1 is provided with an external thread. The lens column 1 is screwed into the mounting hole of the bracket 2 and is mounted on the bracket 2 through the threaded fit between the external thread on the lens column 1 and the internal thread of the mounting hole of the bracket 2.

[0036] The mirror column 1 comprises a mirror column upper section 11 and a mirror column lower section 12. The top of the mirror column upper section 11 is provided with an external convex spherical structure. The external convex spherical structure at the top of the mirror column upper section 11 is used as a substrate 3. A curved microlens array 4 is provided on the substrate 3. The curved microlens array 4 comprises a multi-stage microlens unit. The corresponding field of view focus of each stage of the microlens unit is focused on the same focal plane. Figure 7 The present invention forms a curved microlens array 4 through a multi-level microlens unit located on the top spherical structure of the upper section 11 of the mirror column, so that the artificial cornea has a large field of view and ensures the use effect of the artificial cornea.

[0037] like Figure 6As shown, the arrangement of the microlens units in the curved microlens array 4 is distributed on several concentric circles, and the microlens units on the same concentric circle have the same size and shape, forming a first-level microlens unit. The shape of the microlens unit is a spherical convex point, and the diameter of the microlens unit in the outer circle is smaller than the diameter of the microlens unit in the inner circle. A microlens unit is provided at the center of the top spherical surface of the upper section 11 of the mirror column. The microlens unit is the 0th-level microlens unit, and a circle of microlens units adjacent to the microlens unit constitutes the 1st-level microlens unit. From the 1st-level microlens unit outward, there are the 2nd-level microlens unit, the 3rd-level microlens unit, and so on. In the present invention, Figure 6 Five levels of microlens units are shown, but for a multi-focal length artificial cornea, the number of microlens units is not limited to this number, and can be greater than 5 or less than 5.

[0038] Preferably, the shape of the micro lens unit is hemispherical, and the farther away from the center of the top spherical surface of the upper section 11 of the mirror column, the smaller the radius of the micro lens unit.

[0039] Furthermore, the present invention also provides a method for processing an artificial cornea.

[0040] The method for processing an artificial cornea of ​​the present invention comprises the following steps:

[0041] Step 1, selecting parameters of an artificial cornea lens column with a suitable structure, and manufacturing an upper lens column section 11 and a lower lens column section 12;

[0042] Step 2, coating an anti-glare coating 7 on the inner concave surface at the bottom of the upper mirror column section 11 or the outer convex surface at the top of the lower mirror column section 12;

[0043] Step 3, selecting structurally adapted bracket parameters and manufacturing bracket 2;

[0044] Step 4: Assemble the upper section 11 and the lower section 12 of the mirror column on the bracket 2 to obtain an artificial cornea.

[0045] in:

[0046] In step 1, the existing stable material PMMA, i.e. polymethyl methacrylate, can be selected as the manufacturing material of the lens column 1, and the applicable artificial cornea parameters are selected according to the patient's vision and corneal damage assessment. The artificial cornea parameters include: suitable focal length, diameter, length, etc., so as to select a structurally adapted artificial cornea lens column so that the shape and size of its various parts meet the patient's needs, such as the diameter and height of the top convex surface 3 of the upper segment 11 of the lens column, the bottom concave surface of the upper segment 11 of the lens column, the bottom concave surface 10 of the lower segment 12 of the lens column, and the top convex surface of the lower segment 12 of the lens column.

[0047] The mirror column upper section 11 and the mirror column lower section 12 are manufactured by injection molding.

[0048] In step 2, the concave surface at the bottom of the upper section 11 of the mirror column or the convex surface at the top of the lower section 12 of the mirror column is coated by dipping in an ethanol solution of indium tin oxide nanoparticles with a mass fraction of 25%, and the obtained film is cured in air at 130°C for 20 hours.

[0049] In step 3, the size of the bracket is designed according to an ergonomic structure that fits tightly with the keratin layer of the human body and is not easy to fall off, and the bracket 2 is made of titanium metal or titanium alloy.

[0050] In step 4, the upper section 11 and the lower section 12 are screwed into the mounting holes 6 of the bracket 2 respectively, with the upper section 11 on top and the lower section 12 on the bottom, and the bottom of the upper section 11 abuts against the top of the lower section 12.

[0051] Furthermore, the present invention also provides a method for processing a multi-focal length artificial cornea.

[0052] The method for processing a multifocal artificial cornea of ​​the present invention comprises the following steps:

[0053] Step 1, selecting parameters of an artificial cornea lens column with a suitable structure, and manufacturing an upper lens column section 11 and a lower lens column section 12;

[0054] Step 2, coating an anti-glare coating 7 on the inner concave surface at the bottom of the upper mirror column section 11 or the outer convex surface at the top of the lower mirror column section 12;

[0055] Step 3, selecting structurally adapted bracket parameters and manufacturing bracket 2;

[0056] Step 4: Assemble the upper section 11 and the lower section 12 of the lens column on the bracket 2 to obtain a multi-focal length artificial cornea.

[0057] in:

[0058] In step 1, the existing stable material PMMA, i.e. polymethyl methacrylate, can be selected as the manufacturing material of the lens column 1, and the applicable artificial cornea parameters are selected according to the patient's vision and corneal damage assessment. The artificial cornea parameters include: suitable focal length, diameter, length, etc., so as to select a structurally adapted artificial cornea lens column so that the shape and size of its various parts meet the patient's needs, such as the diameter and height of the top convex surface 3 of the upper segment 11 of the lens column, the bottom concave surface of the upper segment 11 of the lens column, the bottom concave surface 10 of the lower segment 12 of the lens column, and the top convex surface of the lower segment 12 of the lens column.

[0059] Step 1 also includes designing an optical model of the curved microlens array 4, and obtaining the size parameters of each level of microlens units in the curved microlens array 4 by calculation. The details are as follows:

[0060] The corresponding field of view of each level of microlens units in the curved microlens array 4 should be focused on the same focal plane, that is, by changing the focal length of each level of microlens units in the curved microlens array 4, all microlens units can be focused on the same focal plane in the corresponding field of view, thereby obtaining a bionic multi-focal length artificial cornea with a large field of view function, and in order to facilitate the design of the optical model, the top spherical structure of the upper section 11 of the mirror column is used as the substrate 3, and the curved microlens array 4 is arranged on the substrate 3. The arrangement of the microlens units in the curved microlens array 4 is distributed on a number of concentric circles, and the microlens units on the same concentric circle have the same size parameters, and from the center to the edge of the top spherical structure of the upper section 11 of the mirror column, the parameters of the microlens units on each concentric circle will be determined by their positions.

[0061] The radial distance from the microlens unit (center of the hemisphere) to the focal plane decreases from the center of the mirror column to the edge of the mirror column, expressed as l n The radial distance is represented by connecting the spherical center of all microlens units and the spherical center O of the top spherical structure of the upper section 11 of the mirror column with a straight line. The straight line is the principal optical axis of the microlens unit. The line connecting the intersection of the principal optical axis and the focal plane and the spherical center of the microlens unit is the radial distance from the microlens unit to the focal plane. Figure 7 As shown, n The calculation formula is as follows:

[0062]

[0063] Where R0 is the outer diameter of the substrate, l0 is the distance from the microlens unit at the center of the substrate to the focal plane, and α n is the deflection angle of the principal optical axis of the nth ring (level) microlens;

[0064] According to the design requirements, the focal length f of the microlens unit n Should be equal to the radial distance l from the focal plane along its principal optical axis n , that is, the focal length f of the microlens n The calculation formula is as follows:

[0065]

[0066] Among them, l n is the distance between the nth ring microlens unit and the focal plane, R0 is the outer diameter of the substrate, l0 is the distance between the microlens at the center of the substrate and the focal plane, α n is the deflection angle of the principal optical axis of the nth ring (level) microlens;

[0067] Therefore, the radius r of the microlens sphere of the microlens unit in the nth ring is n The calculation formula is as follows:

[0068] When a transparent sphere is used as a lens, its shape is similar to a convex lens. The focal length of a convex lens is related to its radius of curvature, refractive index, and the shape of the lens. However, for a simple sphere model, we can use an approximate formula to estimate its focal length.

[0069] For a radius r n , a transparent sphere with a refractive index of n´ and a focal length of f n An approximate formula is:

[0070]

[0071] Where n' is the refractive index of the microlens unit material, f n is the focal length of the microlens unit.

[0072] The mirror column upper section 11 and the mirror column lower section 12 are manufactured by injection molding.

[0073] In step 1, the existing stable material PMMA, i.e., polymethyl methacrylate, can be selected as the manufacturing material of the mirror column 1. According to the patient's vision and corneal damage assessment, the applicable artificial cornea parameters are selected, and the artificial cornea parameters include: suitable focal length, diameter, length, etc., so as to select a structurally adapted artificial cornea mirror column so that the shape and size of each part thereof meet the patient's needs, such as the diameter and height of the top convex surface 3 of the mirror column upper section 11, the bottom concave surface of the mirror column upper section 11, the bottom concave surface 10 of the mirror column lower section 12, and the top convex surface of the mirror column lower section 12. The curved microlens array 4 is designed according to the above method.

[0074] Furthermore, the curved microlens array 4 can be integrally formed with the artificial cornea lens column by injection molding, that is, the curved microlens array 4 is directly formed on the top convex surface 3 of the upper section 11 of the lens column.

[0075] The processing technology of the mirror column upper section 11 with the curved microlens array 4 includes the following steps: (a) processing the substrate with the concave spherical surface, after cleaning the substrate, spin coating the photoresist and pre-baking; (b) pattern transfer, exposing and developing the substrate after pre-baking, and then partially baking it; (c) mold preparation, etching the substrate after partial baking to form a concave hole array, and passivating it after bonding with borosilicate glass; (d) connecting the substrate and the injection mold of the mirror column upper section 11 body to each other (for example, threaded connection), injection molding, injection molding and demoulding the mold to obtain the mirror column upper section 11 with the curved microlens array 4.

[0076] Specific:

[0077] Substrate treatment: pour 30% hydrogen peroxide solution into concentrated sulfuric acid solution at a volume ratio of 1:3 and heat to boiling; put a P-type silicon substrate of corresponding thickness into the boiling solution and heat for 3 minutes; take it out and rinse it with cold and hot deionized water alternately for 3 times; blow it dry with a nitrogen gun; put the dry and clean silicon substrate into the coating machine cavity; spin-coat the adhesive and photoresist at a uniform speed of 2500 r / min for 30 seconds; then place it on a high-temperature hot plate at 105°C and bake it for 200 seconds; the substrate is provided with an inner concave spherical surface that matches the outer convex surface 3 at the top of the upper section 11 of the mirror column.

[0078] Pattern transfer, using a 365nm wavelength light source photolithography machine in a low vacuum contact mode at a fixed power intensity of 300 W for 45 seconds, placed in a developer for development, and after complete development, the developer is cleaned with deionized water, and the structure of the pattern is checked under a microscope. After it is correct, it is placed on a 105°C high-temperature hot plate and baked for 200 seconds to harden the film; the pattern (pattern) is compatible with the curved microlens array 4.

[0079] Mold preparation: Use an ICP etcher to etch a microhole array of the required depth and diameter at the microlens array 4 pattern position at an etching rate of 6 μm / min. Use an acetone solution to remove the residual glue mask, clean and dry it, and put it into a bonder together with a certain thickness of borosilicate glass for bonding. After cleaning and drying again, put it into an ICP etcher to complete fluorine-based passivation to obtain a substrate mold.

[0080] Injection molding: the substrate mold and the mirror column upper section 11 are connected to each other to form a prepared mold, a polymer is injected into the prepared mold, and after demolding, the mirror column upper section 11 with the curved microlens array 4 is obtained.

[0081] The side walls of the connection between the upper section 11 and the lower section 12 of the mirror column and the bracket 2 are processed with external threads 8 and 9 respectively. In the present invention, after the mold for processing the curved microlens array 4 is prepared, it can be used as one of the components of the injection molding mold for the mirror column 1, and used together with the mold for processing the column body, so that the curved microlens array 4 is formed into one piece with the upper section 11 of the mirror column of the artificial cornea by injection molding.

[0082] The mirror column lower section 12 can be directly injection molded by a corresponding mold.

[0083] In step 2, the concave surface at the bottom of the upper section 11 of the mirror column, or the convex surface at the top of the lower section 12 of the mirror column is coated by dipping in an ethanol solution of indium tin oxide nanoparticles with a mass fraction of 25%, and the obtained film is cured in air at 130°C for 20 hours.

[0084] In step 3, the size of the bracket is designed according to an ergonomic structure that fits tightly with the keratin layer of the human body and is not easy to fall off, and the bracket 2 is made of titanium metal or titanium alloy.

[0085] In step 4, the upper section 11 and the lower section 12 are screwed into the mounting holes 6 of the bracket 2 respectively, with the upper section 11 on top and the lower section 12 on the bottom, and the bottom of the upper section 11 abuts against the top of the lower section 12.

[0086] Through the present invention, it is possible to provide patients with an artificial cornea having at least one function such as multi-focal length, anti-glare, and only needing to replace the upper section of the lens column when replacing. This invention can adapt to the different needs of patients and reduce the surgical trauma and risks of patients. The provided production process also has the advantages of low cost, controllable curvature, simple processing and high repeatability.

[0087] The above are only preferred embodiments of the present invention, and are not intended to limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. An artificial cornea, comprising a lens column and a bracket, characterized in that: The mirror column comprises an upper mirror column section and a lower mirror column section, which are separate components, are both mounted on a bracket, and the upper mirror column section is detachably connected to the bracket; the upper mirror column section is arranged on the upper part of the lower mirror column section, and the bottom of the upper mirror column section abuts against the top of the lower mirror column section; the top of the upper mirror column section is an outer convex surface, and the bottom of the lower mirror column section is an inner concave surface; the bottom of the upper mirror column section is processed with an inner concave surface, and the top of the lower mirror column section is processed with an outer convex surface, and the inner concave surface and the outer convex surface cooperate with each other.

2. The artificial cornea according to claim 1, characterized in that: The upper section of the mirror column is coated with an anti-glare coating at its bottom, or the lower section of the mirror column is coated with an anti-glare layer at its top.

3. The artificial cornea according to claim 1, characterized in that: The upper section of the mirror column is coated with an anti-glare coating on its bottom concave surface, or the lower section of the mirror column is coated with an anti-glare layer on its top convex surface.

4. The artificial cornea according to claim 1, characterized in that: A mounting hole is provided in the center of the bracket, and an internal thread is provided in the mounting hole. The lower outer wall of the upper section of the mirror column is processed with an external thread, and the upper outer wall of the lower section of the mirror column is processed with an external thread. The upper section of the mirror column and the lower section of the mirror column are respectively matched with the mounting hole thread of the bracket through their own external threads.

5. The artificial cornea according to claim 1, characterized in that: Both the outer convex surface and the inner concave surface are spherical.

6. The artificial cornea according to claim 5, characterized in that: The outer convex surface of the top of the upper section of the mirror column is used as a base, and a curved surface microlens array is arranged on the base. The curved surface microlens array includes multi-level microlens units.

7. The artificial cornea according to claim 6, characterized in that: The corresponding field of view focal points of each stage of microlens units are focused on the same focal plane.

8. The artificial cornea according to claim 6, characterized in that: The microlens units in the curved microlens array are arranged on a plurality of concentric circles, and the microlens units on the same concentric circle have the same size and shape, forming a primary microlens unit.

9. The artificial cornea according to claim 6, characterized in that: The diameter of the microlens units in the outer circle is smaller than the diameter of the microlens units in the inner circle.

Citation Information

Patent Citations

  • Keratoprosthesis

    CN102727324A

  • Compound micro lens implant

    US20110040377A1

  • Intracorneal optical implant

    WO2023041747A1