High-stability multifunctional gauze of fiber composite aluminum-based mineral and preparation method thereof

Abstract

The application discloses antibacterial hemostatic gauze and a preparation method thereof. The application relates to the technical field of medical gauze. The preparation method comprises the following steps: after gauze is immersed in a solution containing X cations and dried, the gauze loaded with X cations after drying is immersed in a suspension prepared by mixing an aluminum-based mineral or an aluminum-based mineral composite material and sodium alginate, and then the gauze is dried and reinforced through a hot rolling process to obtain the antibacterial hemostatic gauze; wherein X is one or more of Zn, Ca, Cu and Sr. The application improves the binding force between the aluminum-based mineral or the aluminum-based mineral composite material and the gauze fibers, so that the aluminum-based mineral or the aluminum-based mineral composite material is tightly combined on the gauze fibers, and the problem of mineral material falling off of kaolin-based hemostatic gauze in the use process is effectively solved, and the application has high stability.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical gauze, and particularly relates to a high-stability multifunctional hemostatic gauze of fiber composite aluminum-based minerals and a preparation method thereof. BACKGROUND

[0002] The main forms of hemostatic materials include hemostatic gauze, hemostatic sponge and hydrogel, etc. Hemostatic gauze is the most commonly used wound dressing in clinical practice, and compared with hydrogel and hemostatic sponge, hemostatic gauze is convenient to use and has better environmental tolerance, is economical and practical and is easy to mass-produce and store. It is considered that the preparation of hemostatic gauze by combining inorganic hemostatic components with various fibers is an effective way to improve the hemostatic performance of inorganic materials and effectively expand the application scenarios. The preparation process of hemostatic gauze is to load hemostatic active components (kaolin, zeolite and chitosan, etc.) on the surface of gauze fibers by physical impregnation. For example, QuikClot Combat realizes the combination of kaolin and gauze by water immersion loading, and was approved by the US Food and Drug Administration in 2013 for use in traumatic hemorrhage. The ordinary water immersion process mentioned in Chinese invention patent CN115463242A Kaolin-based hemostatic gauze and preparation method thereof is used to prepare kaolin-based hemostatic gauze through water immersion, rolling and drying. The hemostatic active component of the hemostatic gauze prepared by this process has weak binding force with the fibers, so that the hemostatic active component is still easy to fall off during the use of the gauze, thereby causing side effects such as inflammation and thrombosis, and there is a great safety hazard. Therefore, the key to preparing a stable hemostatic gauze with no active component falling off is the optimization of the formula. SUMMARY

[0003] The present application aims at the above-mentioned deficiencies of the prior art, and provides a high-stability multifunctional hemostatic gauze of fiber composite aluminum-based minerals and a preparation method thereof.

[0004] The preparation method of the high-stability multifunctional hemostatic gauze of fiber composite aluminum-based minerals of the present application comprises the following steps: dipping the gauze in a solution containing X cations and then drying; then dipping the gauze loaded with X cations after drying in a suspension prepared by mixing aluminum-based minerals or aluminum-based mineral composites with sodium alginate, and then drying and reinforcing by hot rolling to obtain an antibacterial hemostatic gauze; wherein X is one or more of Zn, Ca, Cu and Sr.

[0005] Further, the concentration of X cations in the solution of X cations is 0.1%wt-0.5%wt.

[0006] Further, in the suspension, the mass ratio of aluminum-based minerals or aluminum-based mineral composites to sodium alginate is 1:0.3-0.6.

[0007] Further, in the suspension, the concentration of sodium alginate is 0.3%wt-0.6%wt.

[0008] Further, the aluminum-based mineral or aluminum-based mineral composite material is kaolin, zeolite, montmorillonite or a composite material thereof.

[0009] Further, the gauze is a non-woven fabric.

[0010] Further, the base material of the gauze is cotton, polyester, polypropylene, polyester, polyethylene, viscose, silk, wool, rayon or a blended fiber thereof.

[0011] Further, the drying temperature is 60-80℃.

[0012] Further, the dry-wet ratio of the antibacterial hemostatic gauze obtained by the heat rolling process drying and reinforcement is 20%.

[0013] An antibacterial hemostatic gauze prepared by the preparation method.

[0014] The present application uses capillary force to pretreat the gauze fibers with X cations, then configures a suspension of sodium alginate and aluminum-based mineral or aluminum-based mineral composite material, and completes the preparation of the antibacterial hemostatic gauze by water immersion method. + When X cations exist, Na 2+ on the G unit of sodium alginate undergoes ion exchange reaction with divalent cations, and the G unit accumulates to form a stable cross-linked network structure. 2+ 2+ 2+ and composite materials releasing such substances such as ZnO, CaCO3 and CaO cross-link to form stable gels, thereby improving the binding force between the aluminum-based mineral or aluminum-based mineral composite material and the gauze fibers, realizing the close combination of the aluminum-based mineral or aluminum-based mineral composite material on the gauze fibers, and effectively solving the problem of mineral material falling off of the kaolin-based hemostatic gauze during use, and having high stability.

[0015] Sodium alginate has good biocompatibility, and the presence of Ca 2+ during hemostatic application can effectively promote coagulation to achieve rapid hemostasis in cooperation with the aluminum-based mineral or aluminum-based mineral composite material, and the release of Zn 2+ can achieve good antibacterial effect to prevent wound infection.The multi-ion cross-linking has good synergistic hemostatic effect, so that the hemostatic gauze has good hemostatic effect and antibacterial effect. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 An electron microscope image of the SCZ-kaolin-based multifunctional hemostatic gauze prepared in Example 1 and a blank gauze;

[0017] Figure 2-1 ​、 2-1 , 2-3 are the results of crosslinking experiments;

[0018] Figure 3 are the results of flexibility tests;

[0019] Figure 4 , Figure 5 are the results of ultrasound peeling experiments;

[0020] Figure 6 are the results of hemolytic experiments;

[0021] Figure 7 are the results of cytotoxicity experiments;

[0022] Figure 8 are the results of coagulation performance tests;

[0023] Figure 9 , Figure 10 are the results of liver hemostasis experiments;

[0024] Figure 11 are the results of antibacterial experiments. DETAILED DESCRIPTION

[0025] The following are specific embodiments of the present application and further describe the technical solutions of the present application in conjunction with the accompanying drawings, but the present application is not limited to these embodiments.

[0026] The kaolin-based aluminum-based mineral or aluminum-based mineral composite material preparation steps used in the following examples refer to Chinese invention patent 202211182898.X.

[0027] The kaolin-based composite material preparation scheme is as follows:

[0028] 1. Prepare FeOOH solution: prepare 200 ml of 0.4 mol / L FeCl3 solution in a beaker, heat to 70°C, and add 300 ml of 0.4 mol / L NaOH dropwise into the FeCl3 solution through a separatory funnel, (form a reddish-brown FeOOH precipitate) After the dropwise addition is complete, stir for 2 h.

[0029] 2. Synthesis of FeOOH / Kaol: 10 g of Kaol powder is added to 500 ml of FeOOH solution, stirred at 70°C for 2 h, then centrifuged at 8000 rpm, washed with water three times to neutral, and dried in a 60°C oven, and broken down.

[0030] 3. Calcination: dry and broken FeOOH / Kaol is calcined in air, calcined at 250°C for 1 h, calcined at 350°C for 1 h, and calcined at 550°C for 4 h, then ground to ensure that the powder size is below 200 mesh, and the product is labeled as α-Fe2O3 / kaol

[0031] Example 1

[0032] Preparation process of SCZ-kaolin-based multifunctional hemostatic gauze:

[0033] Firstly, the non-woven fabric was immersed in a mixed suspension containing 0.1wt% ZnCl2, 0.2wt% CaCl2, and 0.4wt% ZnO under stirring, and then dried and rolled. The gauze was marked as calcium-zinc non-woven fabric. (The loaded ions and complexes can be selected from Cu 2+ , Sr 2+ , CaCO3, CaO, etc. In this process, Zn 2+ , Ca 2+ were selected. (The non-woven fabric substrate can be selected from cotton, polyester, polypropylene, polyester, polyethylene, viscose, silk, wool, rayon, etc. or their blended fibers). In this process, the non-woven fabric substrate was selected as polyester fiber.

[0034] Secondly, α-Fe2O3 / Kaol and sodium alginate were configured as a suspension in a mass ratio of 1:0.5, and ultrasonic treatment was performed for 0.5h to achieve uniform dispersion. The solvent was pure water, and the α-Fe2O3 / Kaol and sodium alginate were mixed uniformly through air stirring.

[0035] Thirdly, the calcium-zinc non-woven fabric prepared in the first step was immersed in the suspension of α-Fe2O3 / Kaol and sodium alginate under stirring, and then dried and reinforced through a hot rolling process, with a dry-wet ratio of 20%. Then it was cut into pieces with sizes of 7.5cm×1.5m and 7.5cm×3.7m, folded in Z-shape, packaged, sterilized, and obtained as the finished product marked as SCZ-kaolin-based multifunctional hemostatic gauze.

[0036] Example 2

[0037] In Example 1, the mixed suspension containing 0.1wt% ZnCl2, 0.2wt% CaCl2, and 0.4wt% ZnO was replaced by a suspension containing 0.1wt% ZnCl2 and 0.4wt% ZnO, and the rest of the process remained unchanged to prepare SZ-kaolin-based multifunctional hemostatic gauze.

[0038] Example 3

[0039] In Example 1, the mixed suspension containing 0.1wt% ZnCl2, 0.2wt% CaCl2, and 0.4wt% ZnO was replaced by a solution containing 0.2wt% CaCl2 and 0.4wt% ZnO, and the rest of the process remained unchanged to prepare SZC-kaolin-based multifunctional hemostatic gauze.

[0040] Example 4

[0041] The 0.1wt% ZnCl2, 0.2wt% CaCl2, 0.4wt% ZnO mixed suspension in Example 1 is replaced with 0.2wt% CuCl2, 0.4wt% ZnO solution, and the rest of the process remains unchanged to prepare SCU-kaolin-based multifunctional hemostatic gauze.

[0042] Example 5

[0043] The 0.1wt% ZnCl2, 0.2wt% CaCl2, 0.4wt% ZnO mixed suspension in Example 1 is replaced with 0.2wt% SrCl2, 0.2wt% CaCl2, 0.4wt% ZnO solution, and the rest of the process remains unchanged to prepare SCR-kaolin-based multifunctional hemostatic gauze.

[0044] Example 6

[0045] The α-Fe2O3 / Kaol in Example 2 is replaced with montmorillonite, and the rest of the process remains unchanged to prepare SCZ-montmorillonite multifunctional hemostatic gauze.

[0046] Example 7

[0047] The α-Fe2O3 / Kaol in Example 2 is replaced with kaolin, and the rest of the process remains unchanged to prepare SCZ-kaolin multifunctional hemostatic gauze.

[0048] Example 8

[0049] The α-Fe2O3 / Kaol in Example 2 is replaced with zeolite, and the rest of the process remains unchanged to prepare SCZ-zeolite multifunctional hemostatic gauze.

[0050] Example 9

[0051] The polyester fiber in Example 1 is replaced with cotton, and the rest of the process remains unchanged to prepare antibacterial hemostatic gauze.

[0052] Comparative Example 1

[0053] Untreated blank non-woven fabric, substrate is polyester;

[0054] Comparative Example 2

[0055] A commercially available kaolin first-aid hemostatic dressing product is used as a control group and is labeled as a commercially available kaolin hemostatic product.

[0056] Comparative Example 3

[0057] The calcium-zinc non-woven fabric water immersion is replaced with a suspension of α-Fe2O3 / Kaol and chitosan (CS) in a mass ratio of 1:0.5 under stirring, and after drying, it is labeled as CS-kaolin hemostatic gauze.

[0058] Comparative Example 4

[0059] The calcium zinc non-woven fabric was immersed in a suspension of a-Fe2O3 / Kaol and polyethylene glycol (PEG) in a mass ratio of 1:0.5 under stirring, and after drying, it was marked as PEG-kaolin hemostatic gauze.

[0060] Comparative Example 5

[0061] The calcium zinc non-woven fabric was immersed in a suspension of a-Fe2O3 / Kaol and polyvinylpyrrolidone (PVP K30) in a mass ratio of 1:0.5 under stirring, and after drying, it was marked as PVP-kaolin hemostatic gauze.

[0062] Comparative Example 6

[0063] The calcium zinc non-woven fabric was immersed in a suspension of a-Fe2O3 / Kaol and polyvinyl alcohol (PVA) in a mass ratio of 1:0.5 under stirring, and after drying, it was marked as PVA-kaolin hemostatic gauze.

[0064] Comparative Example 7

[0065] In Example 1, a-Fe2O3 / Kaol and sodium alginate were replaced with a mass ratio of 1:0.5 instead of 1:1, and the rest of the process remained unchanged to prepare SZC-kaolin-based multifunctional hemostatic gauze.

[0066] Comparative Example 8

[0067] In Example 1, a-Fe2O3 / Kaol and sodium alginate were replaced with a mass ratio of 1:0.5 instead of 1:0.7, and the rest of the process remained unchanged to prepare SZC-kaolin-based multifunctional hemostatic gauze.

[0068] Surface morphology analysis:

[0069] The surface of the blank non-woven fabric and the SCZ-kaolin-based multifunctional hemostatic gauze was observed by scanning electron microscopy (SEM) as shown in Figure 1 , where smooth fibers on the surface of the blank non-woven fabric and uniformly loaded sheet-shaped kaolin-based hemostatic materials on the surface of the SCZ-kaolin-based multifunctional hemostatic gauze can be seen.

[0070] Ion crosslinking experiment:

[0071] SA, CS, PEG, PVP, PVA were respectively crosslinked with Ca 2+ and Zn 2+ , and mixed suspension Zn 2+ , Ca 2+ , ZnO, and the experimental results are as follows Figure 2-1 , 2-2, 2-3 only SA and these several types of divalent cations, and the substances releasing such divalent cations such as zinc oxide, calcium oxide can cross-link to form stable water-insoluble gel, thus the capillary force can be used to introduce such divalent cations (Cu 2+ , Sr 2+ , Zn 2+ , Ca 2+ ) or substances (zinc oxide, calcium oxide) to the surface of the fiber, and the cross-linking and combination of SA and the suspension of a-Fe2O3 / Kaol can help to form a highly stable water-insoluble coating on the surface of the fiber, and realize the stable and independent loading of kaolin inorganic minerals on the surface of the fiber, and prepare a highly stable SCZ-kaolin-based multifunctional hemostatic gauze.

[0072] Flexibility test:

[0073] By continuously optimizing the process scheme, the concentration ratio between the mixed suspension of SA, a-Fe2O3 / Kaol and the ion suspension of Zn 2+ , Ca 2+ , ZnO is adjusted. The SCZ-kaolin-based multifunctional hemostatic gauze prepared by a-Fe2O3 / Kaol and sodium alginate in a higher mass ratio such as 1:1, 1:0.7 has poor flexibility. By adjusting the ratio of a-Fe2O3 / Kaol and sodium alginate to 1:0.5, the flexibility test results are shown in Figure 3 , and finally a SCZ-kaolin-based multifunctional hemostatic gauze with good flexibility is prepared, which effectively broadens the application scenarios of the multifunctional hemostatic gauze.

[0074] Ultrasonic peeling experiment:

[0075] The SCZ-kaolin-based multifunctional hemostatic gauze is placed in deionized water and subjected to ultrasonic treatment at different time intervals of 2, 4, 6, 8 and 10 min to evaluate the firmness of the fiber combination. The tightness of the kaolin hemostatic material on the gauze is detected, and then the sample is dried at 60°C overnight and weighed. The calculation formula of the residual mass ratio is as follows: residual mass ratio = (mass after washing-mass before washing) / mass before washing. The experimental results are shown in Figure 4 , the residual mass ratio of the SCZ-kaolin-based multifunctional hemostatic gauze after 10 min of ultrasonic treatment is 98.2%, while the residual mass ratio of the commercially available kaolin hemostatic product after 10 min of ultrasonic treatment is 59.3%, and a large amount of kaolin hemostatic material on the surface falls off. The kaolin-based hemostatic material on the surface of the SCZ-kaolin-based multifunctional hemostatic gauze is very tightly combined with the fiber, and the amount of kaolin hemostatic material falling off is extremely low. It performs well in harsh ultrasonic peeling experiments, effectively solving the problem of mineral falling off in the past kaolin-based hemostatic gauze.

[0076] The SCZ-kaolin-based multifunctional hemostatic gauze, CS-kaolin hemostatic gauze, PEG-kaolin hemostatic gauze, PVP-kaolin hemostatic gauze and PVA-kaolin hemostatic gauze were placed in deionized water and subjected to ultrasonic treatment for 2 min. The tightness of the kaolin-based hemostatic material combined on the gauze was evaluated by observing the shedding of the kaolin-based hemostatic material in the reagent bottle. The experimental results are shown in Figure 5 As shown in Table 1, the kaolin-based hemostatic material on the surface of the CS-kaolin hemostatic gauze, PEG-kaolin hemostatic gauze, PVP-kaolin hemostatic gauze and PVA-kaolin hemostatic gauze was severely shed, showing a brick red suspension of the kaolin-based hemostatic material α-Fe2O3 / Kaol and water, while no shedding was found in the SCZ-kaolin-based multifunctional hemostatic gauze. This indicates that the kaolin-based hemostatic material on the surface of the SCZ-kaolin-based multifunctional hemostatic gauze is very tightly combined with the fibers.

[0077] Hemolysis experiment:

[0078] The citrate rabbit blood was used for the hemolysis experiment. First, the citrate rabbit blood was centrifuged at a speed of 2500 rpm for 5 min, and the red blood cells were separated and prepared into a 10% red blood cell suspension with a phosphate buffer (PBS). The experimental steps were as follows: 5 mg of gauze sample was added to 800 μL of PBS to prepare a material solution of different samples, and 200 μL of the prepared 10% red blood cell suspension was mixed, and then the mixture was incubated at 37°C for 2 h. At the same time, a negative control group and a positive control group were set. The negative control group did not occur hemolysis, and 800 μL of PBS was mixed with the prepared 200 μL of 10% red blood cell suspension; the positive control group occurred hemolysis, and 800 μL of deionized water was mixed with the prepared 200 μL of 10% red blood cell suspension. Three groups of parallel experiments were set for each sample. The mixed system after incubation at constant temperature was centrifuged at a speed of 2500 rpm for 10 min, and the supernatant was collected, and the absorbance OD value at a wavelength of 540 nm was measured by an enzyme marker.

[0079] The experimental results are shown in Table 2. Figure 6 As shown in Table 2, the hemolysis rate of the blank non-woven fabric was 0.95%, and the hemolysis rate of the SCZ-kaolin-based multifunctional hemostatic gauze was only 1.21%, which was far less than 5%, and had a lower hemolysis rate, showing good blood compatibility.

[0080] Cytotoxicity experiment:

[0081] The CCK-8 method was used to analyze the cytotoxicity of the samples on human umbilical vein endothelial cells (HUVEC cells). The experimental scheme is as follows: RPMI-1640 basic medium and 1% double antibody, 10% fetal bovine serum were used to prepare complete culture medium for culturing HUVEC cells. The normal frozen HUVEC cells were taken out and continuously shaken in a 37°C water bath environment until thawed. 1 mL of HUVEC cell frozen solution was added to a 15 mL centrifuge tube containing 10 mL of complete culture medium, shaken and mixed, and centrifuged at 1000 rpm for 5 min. After removing the supernatant, the cells were resuspended with complete culture medium, and the cell suspension was transferred to a culture dish. After the cells were cultured to a good adherent growth state, trypsin was used for digestion to resuspend the cells. The cell suspension density was adjusted to 1 × 10 4 cells per well, and the cells were inoculated in a 96-well plate. After incubation in a 37°C, 5% CO2 cell culture box environment to a good adherent production state, the original culture medium was discarded, 100 μL of fresh complete culture medium was added to the control wells, and 100 μL of culture medium containing different concentrations of samples was added to the test wells. After adding the materials, continue to culture for 24 h and 48 h to determine the cytotoxicity, i.e. add 10% CCK-8 reagent-containing complete culture medium to each well, continue to culture for 1 h, and measure the absorbance OD value at 450 nm of the culture medium by an enzyme marker. At the same time, the wells without adding sample materials were used as blank control group, and the cell survival rate was calculated by measuring the absorbance. The cell survival rate is calculated as follows:

[0082] Cell survival rate = (OD 实验孔 - OD 空白孔 ) / (OD 对照孔 - OD 空白孔 ) × 100%

[0083] This section uses 1, 2, and 4 mg / mL concentration gradient samples for toxicity evaluation, and the experimental results are shown in Figure 7 Table 2. The cell survival rate of SCZ-kaolin-based multifunctional hemostatic gauze is greater than 100% after 24 h and 48 h of incubation, and αSCZ-kaolin-based multifunctional hemostatic gauze shows extremely low cytotoxicity and effectively promotes cell proliferation. In the cytotoxicity grade, when the cell survival rate is greater than 75%, it is designated as reaching the first level of biological safety. The test results show that the SCZ-kaolin-based multifunctional hemostatic gauze reaches the first level of biological safety, and has good biocompatibility.

[0084] Coagulation performance test:

[0085] In vitro coagulation test was performed using sodium citrate rabbit whole blood. The samples (10 mg) were placed on the bottom of the test tube, and then the whole blood with calcium supplement (100 μL) was added (negative control group, NC, sodium citrate whole blood (100 μL) without sample treatment; positive control, PC, 100 μL whole blood without sample treatment). After coagulation for 3 min in a 37 °C incubator, the reaction was terminated by carefully adding deionized water (2 mL) along the tube wall. The hemoglobin absorbance of free red blood cells in the supernatant was measured at 540 nm wavelength using a microplate reader. The coagulation index (BCI) was calculated by the following formula: BCI = OD sample / OD negative control x 100%, the higher the coagulation index, the slower the coagulation speed. The experimental results are shown in Figure 8 Table 1, the SCZ-kaolin-based multifunctional hemostatic gauze has the lowest coagulation index and the fastest coagulation speed, and has good coagulation-promoting performance.

[0086] Liver hemostasis experiment:

[0087] The hemostatic performance of the material was evaluated by establishing a mouse liver model. Six-week-old female mice (25-30 g) were randomly divided into three groups: blank non-woven fabric, SCZ-kaolin-based multifunctional hemostatic gauze, and commercially available kaolin hemostatic product, 5 mice in each group. The mice were anesthetized by intraperitoneal injection of 10% chloral hydrate. The rats were placed in a supine position, the abdomen was disinfected with 70% ethanol, and the skin was prepared. Sterile gauze was prepared in advance, and the initial weight of the gauze was measured using an electronic balance. The right lobe of the liver was found by opening the abdominal cavity and wrapping it with sterile gauze. A 10 mm long bleeding wound was made on the right lobe of the liver, and the blank non-woven fabric, SCZ-kaolin-based multifunctional hemostatic gauze, and commercially available kaolin hemostatic product were added, respectively. The blood flowing out of each group was collected, and the timer was started at the same time to record the bleeding time of each group. When the bleeding of the liver in each group stopped completely, the timer was stopped, and the time at this moment was the bleeding time of each group. The final weight of the sterile gauze and the corresponding material in each group was measured, and the initial weight of each was subtracted to obtain the bleeding volume of each group.

[0088] The experimental results are shown in Figure 9 , Figure 10 The bleeding time of the SCZ-kaolin-based multifunctional hemostatic gauze was 62.8 ± 6.1 s, and the bleeding volume was 80 ± 41.8 mg. This was much lower than the blank non-woven fabric with a bleeding time of 212.6 ± 15.6 s and a bleeding volume of 404 ± 84.7 mg, and the commercially available kaolin hemostatic product with a bleeding time of 111.2 ± 22.1 s and a bleeding volume of 120 ± 27.3 mg. The results showed that the SCZ-kaolin-based multifunctional hemostatic gauze had excellent hemostatic performance.

[0089] Antibacterial experiment:

[0090] Gram-negative and Gram-positive bacteria were Escherichia coli (ATCC-25922) and Staphylococcus aureus (ATCC-25923), respectively. The bacterial colonies were dispersed in 5 mL of broth, shaken at 37°C for 12 h, and the bacterial solution was diluted (10 5～6 cfu mL -1 ). The bacterial solution was prepared and mixed with two different samples, SCZ-kaolin-based multifunctional hemostatic gauze and blank non-woven fabric, respectively. Then they were put into a constant temperature shaker, shaken at 180 r / min -1 for 4 h at 37°C. The plate coating experiment was repeated three times in parallel. The experimental results are shown in Figure 11 , the antibacterial rates of SCZ-kaolin-based multifunctional hemostatic gauze against Escherichia coli and Staphylococcus aureus were 97.5% and 99.1%, respectively. Compared with the blank group and blank non-woven fabric, it has good antibacterial effect.

[0091] The above not involved, applicable to the prior art.

[0092] Although some specific embodiments of the present application have been described in detail by examples, those skilled in the art should understand that the above examples are only for illustration, not for limiting the scope of the present application, and those skilled in the art can make various modifications or supplements to the described specific embodiments or replace them with similar ways, but will not deviate from the direction of the present application or exceed the scope defined by the appended claims. Those skilled in the art should understand that any modification, equivalent replacement, improvement, etc. made according to the technical essence of the present application to the above embodiments shall be included in the protection scope of the present application.

Claims

1. A method for preparing a high-stability multifunctional gauze for hemostasis of a fibrous composite aluminum-based mineral, characterized in that: The gauze is immersed in a solution containing X cations and zinc oxide, and then dried; the dried gauze loaded with X cations is immersed in a suspension of an aluminum mineral or an aluminum mineral composite and sodium alginate, and then dried and reinforced by a hot rolling process, to obtain an antibacterial hemostatic gauze; wherein X is one or more of Zn, Ca, Cu, and Sr; The concentration of X cations in the solution is 0.1%wt-0.5%wt; In the suspension, the mass ratio of the aluminum mineral or the aluminum mineral composite to sodium alginate is 1:0.3-0.6; In the suspension, the concentration of sodium alginate is 0.3%wt-0.6%wt.

2. The production method according to claim 1, characterized by: The aluminum mineral is one or more of kaolin, zeolite, and montmorillonite.

3. The production method according to claim 1, wherein: The gauze is a non-woven fabric.

4. The production method according to claim 1, wherein: The base material of the gauze is cotton, polyester, polypropylene, polyester, polyethylene, viscose, silk, wool, rayon, or a blended fiber thereof.

5. The production method according to claim 1, wherein: The drying temperature is 60-80℃.

6. The production method according to claim 1, wherein: The dry-wet ratio of the antibacterial hemostatic gauze obtained by drying and reinforcing by the hot rolling process is 20%.

7. A high-stability multifunctional hemostatic gauze of a fiber composite aluminum mineral prepared by the preparation method of any one of claims 1-6.

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