Composition for calming nerves and promoting sleep containing agarwood leaves, preparation method and use thereof, and health tea

Abstract

The present application embodiment discloses a soothing and sleep-aiding composition containing agarwood leaves, and its preparation method, use, and health tea. The soothing and sleep-aiding composition includes, by weight: agarwood leaves: 10-18 parts; Alpinia oxyphylla: 5-12 parts; Polygonum multiflorum: 8-16 parts; Platycladus orientalis: 8-16 parts; Theanine: 3-7 parts. In the soothing and sleep-aiding composition of the present application embodiment, the combination of Platycladus orientalis leaves and agarwood leaves has a better sedative effect, and Alpinia oxyphylla can promote brain blood circulation together with theanine, thereby better improving sleep quality; on this basis, Polygonum multiflorum has both the effects of calming and calming the mind and improving sleep quality, thereby not only improving the sedative effect of the soothing and sleep-aiding composition, but also further improving sleep quality.

Description

Technical Field

[0001] The present application relates to the technical field of sedative and sleep-inducing compositions, and in particular to a sedative and sleep-inducing composition containing agarwood leaves, a preparation method and use thereof, and a health tea. Background Art

[0002] With the acceleration of modern life and the increase of work pressure, more and more people are suffering from sleep disorders. The main symptoms of insomnia are: difficulty falling asleep, poor sleep quality, and short sleep time. Related studies have shown that long-term insomnia can cause physiological dysfunction, fatigue, memory loss and other symptoms. Severe cases may also cause other adverse symptoms and induce related diseases (such as anxiety, depression, hypertension, etc.).

[0003] Therefore, how to improve insomnia and enhance sleep quality is an urgent problem to be solved. Summary of the invention

[0004] The purpose of the present application is to provide a tranquilizing and sleep-inducing composition containing agarwood leaves, a preparation method and use thereof, and a health tea.

[0005] To achieve the above technical objectives, the present application provides the following technical solutions:

[0006] In a first aspect, an embodiment of the present application provides a tranquilizing and sleep-inducing composition containing agarwood leaves, wherein the tranquilizing and sleep-inducing composition comprises, by weight:

[0007] Agarwood leaves: 10-18 parts;

[0008] Alpinia oxyphylla kernel: 5-12 portions;

[0009] Polygonum multiflorum: 8-16 parts;

[0010] Pineapple seeds: 8-16 servings;

[0011] Theanine: 3-7 parts.

[0012] As an embodiment, the tranquilizing and sleeping-aiding composition comprises, by weight:

[0013] Agarwood leaves: 14-16 parts;

[0014] Alpinia oxyphylla kernel: 6-8 portions;

[0015] Polygonum multiflorum: 12-16 parts;

[0016] Pine nuts: 8-10 portions;

[0017] Theanine: 4-6 parts.

[0018] As an embodiment, the tranquilizing and sleeping-aiding composition further comprises, by weight:

[0019] Chinese date seeds: 3-6 servings.

[0020] As an embodiment, the tranquilizing and sleeping-aiding composition comprises, by weight:

[0021] Chinese date seeds: 4-6 servings.

[0022] The second aspect of the embodiment of the present application provides a method for preparing the tranquilizing and sleep-inducing composition containing agarwood leaves as described in the first aspect, the preparation method comprising:

[0023] Weigh each component in proportion;

[0024] The components are mixed evenly to obtain a tranquilizing and sleep-aiding composition.

[0025] As an embodiment, the components are mixed evenly to obtain a tranquilizing and sleep-aiding composition, comprising:

[0026] The components are dried and crushed, and then passed through a 60-80 mesh sieve and mixed evenly to obtain a tranquilizing and sleep-aiding composition.

[0027] The third aspect of the embodiments of the present application proposes the use of the tranquilizing and sleeping-aiding composition containing agarwood leaves according to the first aspect in the preparation of a medicine for preventing, alleviating or treating insomnia symptoms.

[0028] As an embodiment, the drug further comprises a pharmaceutically acceptable adjuvant.

[0029] The fourth aspect of the embodiment of the present application provides a health tea, which includes the sedative and sleep-aiding composition containing agarwood leaves as described in the first aspect.

[0030] As an embodiment, the health tea further comprises: 1-10 parts of a taste regulator;

[0031] Wherein, the taste regulator is selected from at least one of sucrose, honey, maple syrup, xylitol, stevia and monk fruit sugar.

[0032] The embodiments of the present application have the following beneficial effects:

[0033] In the tranquilizing and sleep-aiding composition of this embodiment, the combination of cypress seeds and agarwood leaves has a better sedative effect (shortening the sleep latency period), and the Alpinia oxyphylla can promote blood circulation in the brain together with theanine, thereby better improving the sleep quality (extending the sleep time); on this basis, Polygonum multiflorum has the effects of calming the mind and improving the sleep quality, thereby not only improving the sedative effect of the tranquilizing and sleep-aiding composition (shortening the sleep latency period), but also further improving the sleep quality (extending the sleep time).

[0034] Therefore, the tranquilizing and sleep-aiding composition of this embodiment can work together from the two aspects of calming the mind (shortening sleep latency) and improving sleep quality (extending sleep time) to enhance the tranquilizing and sleep-aiding effect.

[0035] Additional aspects and advantages of the present application will be partially given in the following description, which will become apparent from the following description, or will be understood through the practice of the present application. DETAILED DESCRIPTION

[0036] In order to more fully understand the technical content of the present application, the present application will be further introduced and illustrated in conjunction with specific embodiments below; obviously, the embodiments described below are only part of the embodiments of the present application, rather than all of the embodiments; based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making any creative work are within the scope of protection of the present application.

[0037] For those skilled in the art, the features, beneficial effects and advantages of the present application will become apparent by reading the contents disclosed in this specification.

[0038] The term "mass content" herein may be represented by the symbol "part(s)".

[0039] As used herein, "includes," "comprising," "including," "containing," "having," or other variations are intended to encompass non-closed inclusions, and no distinction is made between these terms. The term "comprising" means that other steps and ingredients that do not affect the end result may be added. The term "comprising" also includes the terms "consisting of" and "consisting essentially of." The compositions and methods / processes of the present application may include, consist of, and consist essentially of the essential elements and limitations described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein.

[0040] The relevant components in this application can be purchased from the market or extracted or prepared by conventional methods known in the art.

[0041] Specifically, in this embodiment:

[0042] The agarwood leaves are fresh agarwood leaves picked from Chenxiang Mountain in Guanzhu Town, Dianbai District, Maoming City;

[0043] Theanine was purchased from Hunan Jinnong Biological Resources Co., Ltd. with the brand name KL-NLTE002;

[0044] Alpinia oxyphylla was purchased from Baoji Liupanyun Biotechnology Co., Ltd.

[0045] Polygonum multiflorum was purchased from Bozhou Huozhengtang Pharmaceutical Co., Ltd.;

[0046] Semen pine nuts were purchased from Baoji Liupanyun Biotechnology Co., Ltd.;

[0047] Ziziphus jujuba seeds were purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0048] The tranquilizing and sleep-inducing composition in the examples of the present application, as well as its preparation method and use are described in detail below.

[0049] First, the tranquilizing and sleeping-aiding composition of this embodiment is described.

[0050] Composition for calming nerves and promoting sleep containing agarwood leaves

[0051] This embodiment provides a tranquilizing and sleep-inducing composition containing agarwood leaves. Calculated by weight, the tranquilizing and sleep-inducing composition includes: agarwood leaves: 10-18 parts; Alpinia oxyphylla seeds: 5-12 parts; Polygonum multiflorum vine: 8-16 parts; Platycladus orientalis seeds: 8-16 parts; and theanine: 3-7 parts.

[0052] In this embodiment, on the basis of agarwood leaves, Alpinia oxyphylla, Polygonum multiflorum, Platycladus orientalis seeds and theanine are further used to obtain a tranquilizing and sleep-aiding composition; the tranquilizing and sleep-aiding composition of this embodiment not only has a better sedative effect (shortening sleep latency), but also can improve sleep quality (extending sleep time), thereby improving the tranquilizing and sleep-aiding effect from many aspects.

[0053] Specifically, in this embodiment: the active ingredients (oleic acid, linoleic acid and β-sitosterol) contained in the cypress seeds can promote the release of GABA in the synaptic cleft and bind to the corresponding receptors, thereby achieving a calming and tranquilizing effect. At the same time, the agarwood furan contained in the agarwood leaves has good central nervous system sedative and hypnotic activity, and can enhance the function of GABA receptors to exert its sedative and hypnotic effect; therefore, the combination of the cypress seeds and agarwood leaves in this embodiment has a better sedative effect. At the same time, the Alpinia oxyphylla in this embodiment can increase the expression of melatonin receptors, promote blood circulation in the brain, and thus improve sleep quality; theanine can regulate the balance of brain neurotransmitters, increase the content of substances such as serotonin and dopamine, and promote blood circulation in the brain, thereby improving sleep quality together with the Alpinia oxyphylla.

[0054] Furthermore, the Polygonum multiflorum added in this embodiment not only has a calming and tranquilizing effect, but also nourishes the blood and improves blood circulation. Specifically, the amino acids, vitamins and other nutrients in Polygonum multiflorum can regulate the function of the nervous system, improve blood circulation, and help improve sleep quality.

[0055] Therefore, in the tranquilizing and sleep-aiding composition of this embodiment, the combination of cypress seeds and agarwood leaves has a better sedative effect (shortening the sleep latency period), and the Alpinia oxyphylla can promote blood circulation in the brain together with theanine, thereby better improving the sleep quality (extending the sleep time); on this basis, Polygonum multiflorum has both the effects of tranquilizing and calming the mind and improving the sleep quality, thereby not only improving the sedative effect of the tranquilizing and sleep-aiding composition (shortening the sleep latency period), but also further improving the sleep quality (extending the sleep time).

[0056] In summary, the tranquilizing and sleep-aiding composition of this embodiment can work together from the two aspects of calming the mind (shortening sleep latency) and improving sleep quality (extending sleep time) to enhance the overall tranquilizing and sleep-aiding effect.

[0057] As a preferred embodiment, the above-mentioned tranquilizing and sleep-aiding composition comprises, by weight: 14-16 parts of agarwood leaves; 6-8 parts of Alpinia oxyphylla seeds; 12-16 parts of Polygonum multiflorum vines; 8-10 parts of Platycladus orientalis seeds; and 4-6 parts of theanine.

[0058] For example, in this embodiment:

[0059] The content of agarwood leaves includes but is not limited to: 10 parts, 10.3 parts, 11 parts, 11.7 parts, 12 parts, 12.2 parts, 12.4 parts, 13 parts, 13.7 parts, 14 parts, 14.6 parts, 15 parts, 15.4 parts, 16 parts, 17 parts, 17.3 parts, and 18 parts.

[0060] The content of Alpinia oxyphylla kernel includes but is not limited to: 5 parts, 5.5 parts, 5.9 parts, 6 parts, 6.5 parts, 6.6 parts, 7 parts, 7.2 parts, 7.6 parts, 8 parts, 8.5 parts, 8.8 parts, 9 parts, 9.4 parts, 9.5 parts, 9.6 parts, 10 parts, 10.3 parts, 11 parts, 11.7 parts, and 12 parts.

[0061] The content of Polygonum multiflorum includes but is not limited to: 8 parts, 8.5 parts, 8.8 parts, 9 parts, 9.4 parts, 9.5 parts, 9.6 parts, 10 parts, 10.3 parts, 11 parts, 11.7 parts, 12 parts, 12.2 parts, 12.4 parts, 13 parts, 13.7 parts, 14 parts, 14.5 parts, 14.9 parts, 15 parts, 15.5 parts, 15.6 parts, and 16 parts.

[0062] The content of pine nuts includes but is not limited to: 8 parts, 8.5 parts, 8.8 parts, 9 parts, 9.4 parts, 9.5 parts, 9.6 parts, 10 parts, 10.3 parts, 11 parts, 11.7 parts, 12 parts, 12.2 parts, 12.4 parts, 13 parts, 13.7 parts, 14 parts, 14.5 parts, 14.9 parts, 15 parts, 15.5 parts, 15.6 parts, and 16 parts.

[0063] The content of theanine includes but is not limited to: 3 parts, 3.3 parts, 4 parts, 4.7 parts, 5 parts, 5.2 parts, 5.4 parts, 6 parts, 6.7 parts, and 7 parts.

[0064] Chinese date seed

[0065] In addition to the above components, the tranquilizing and sleep-aiding composition of this embodiment, as a preferred implementation of this embodiment, further comprises: 3-6 parts of Ziziphus jujuba seeds, preferably 4-6 parts.

[0066] Among them, this example has been verified to find that further adding Chinese date seeds to the above-mentioned tranquilizing and sleep-inducing composition has a better tranquilizing and sleep-inducing effect. It is speculated that the principle may be:

[0067] In the tranquilizing and sleeping-aiding composition, the alkaloids and saponins contained in the Chinese date seeds can not only have a hypnotic and sedative effect, but also help promote blood circulation in the brain and improve the situation of insufficient blood supply to the brain, thereby achieving the purpose of improving sleep quality.

[0068] Therefore, the tranquilizing and sleeping-aiding composition of this embodiment can better improve insomnia and enhance sleep quality.

[0069] In this embodiment:

[0070] Illustratively, the content of sour jujube kernel includes but is not limited to 3 parts, 3.2 parts, 3.4 parts, 4 parts, 4.7 parts, 4.9 parts, 5 parts, 5.1 parts, 5.5 parts, 5.9 parts, and 6 parts.

[0071] Next, the preparation method of the above-mentioned tranquilizing and sleep-aiding composition will be described in detail.

[0072] Preparation method

[0073] The tranquilizing and sleep-aiding composition of this embodiment can be prepared by conventional methods known in the art.

[0074] Exemplarily, the preparation method comprises:

[0075] Weigh each component in proportion;

[0076] The components are mixed evenly to obtain a tranquilizing and sleep-aiding composition.

[0077] The mixing operation can be achieved by using a conventional stirring device, such as a stirring barrel.

[0078] Each step of the above preparation method will be further described below.

[0079] The components are mixed evenly to obtain a tranquilizing and sleep-aiding composition, comprising:

[0080] The components are dried and crushed, and then passed through a 60-80 mesh sieve and mixed evenly to obtain a tranquilizing and sleep-aiding composition.

[0081] Specifically: after drying each component in an oven at 50° C. for 20 minutes, crush it with a crusher and pass it through a 60-80 mesh (preferably 80 mesh) sieve, add it into a stirring barrel and stir evenly to obtain a tranquilizing and sleep-aiding composition.

[0082] As another preparation method, the following steps can be adopted:

[0083] Weigh each component in proportion, place each component in a 50°C oven to dry for 20 minutes, use a grinder to crush and pass through an 80-mesh sieve, add 90% ethanol solution to the crushed component, and the solid-liquid ratio is 1:25 g / mL; then place it in an 80°C water bath for extraction for 65 minutes, filter it with a circular filter paper, and use the filtrate for later use; add ethanol to the filter residue again, repeat the extraction once according to the above conditions, and then filter it with a circular filter paper, combine the two extraction filtrates, put it in a constant temperature drying oven, and dry it at 50°C for 3.5 hours to obtain a mixture powder;

[0084] (2) In a supercritical extraction device, the mixture powder is extracted using a carbon dioxide supercritical fluid at an extraction temperature of 40° C. and a pressure of 35 MPa. The flow rate of the supercritical carbon dioxide fluid is set to 300 L / h. After 3.5 hours of extraction, an extract is obtained;

[0085] (3) adding the extract into a stirring bucket and mixing evenly to obtain a tranquilizing and sleep-inducing composition.

[0086] As another optional preparation method, the following steps can be used:

[0087] (1) Weigh each component in proportion, place each component in a 50°C oven and dry for 20 minutes, use a grinder to grind the components except the agarwood leaves and pass them through an 80-mesh sieve, add 90% ethanol solution to the grinded components (excluding agarwood leaves), and the solid-liquid ratio is 1:25 g / mL; then place it in an 80°C water bath for extraction for 65 minutes, filter it with a circular filter paper, and set aside the filtrate; add ethanol to the filter residue again, repeat the extraction once according to the above conditions, and then filter it with a circular filter paper, combine the two extraction filtrates, put it in a constant temperature drying oven, and dry it at 50°C for 3.5 hours to obtain a mixture powder (excluding agarwood leaves);

[0088] (2) In a supercritical extraction device, the mixture powder (excluding agarwood leaves) was extracted using a carbon dioxide supercritical fluid, the extraction temperature was 40° C., the pressure was 35 MPa, the flow rate of the supercritical carbon dioxide fluid was set to 300 L / h, and after 3.5 hours of extraction, an extract (excluding agarwood leaves) was obtained;

[0089] (3) The extract (excluding agarwood leaves) is soaked in water (water temperature 95°C) (the solid-liquid ratio of the extract to water is 1:50-60 g / mL) to obtain an soaking liquid, and the dried agarwood leaves are added to the soaking liquid (the solid-liquid ratio of the agarwood leaves to the soaking liquid is 1:45 g / mL). After the agarwood leaves completely absorb the soaking liquid, the soaked agarwood leaves are taken out and dried (e.g., dried in an oven at 45-50°C for 20-30 min) to obtain a tranquilizing and sleep-inducing composition.

[0090] Next, the method for using the above-mentioned tranquilizing and sleep-aiding composition will be described in detail.

[0091] How to use

[0092] The tranquilizing and sleep-aiding composition of this embodiment can be added to drinking water and then soaked before drinking.

[0093] Exemplarily, the solid-liquid ratio of the sedative and sleep-aiding composition and drinking water is 1:50-100 g / mL, preferably 1:60-80 g / mL; Exemplarily: the solid-liquid ratio of the sedative and sleep-aiding composition and drinking water is 1:50 g / mL, 1:60 g / mL, 1:70 g / mL, 1:75 g / mL, 1:80 g / mL, 1:90 g / mL, 1:100 g / mL.

[0094] Usually, the temperature of the added drinking water is 90-100°C, preferably 95°C; the soaking time is usually 3-7 minutes, preferably 5-6 minutes.

[0095] For the convenience of use, the tranquilizing and sleeping-aiding composition can also be made into a tea bag form using a corn fiber bag, for example, with a weight of 5-10 g / bag.

[0096] Next, the use of the above-mentioned tranquilizing and sleep-aiding composition will be further explained.

[0097] use

[0098] Since the tranquilizing and sleep-aiding composition of this embodiment can improve insomnia and enhance sleep quality, the tranquilizing and sleep-aiding composition provided in this embodiment can be used to prepare a drug for preventing, alleviating or treating insomnia symptoms.

[0099] That is, the tranquilizing and sleep-aiding composition of this embodiment can be used as a basis, and pharmaceutically acceptable adjuvants can be added to prepare a medicine for preventing, alleviating or treating insomnia symptoms.

[0100] Exemplarily, the insomnia symptoms include, but are not limited to: difficulty falling asleep, decreased sleep quality, short sleep time, etc.

[0101] Exemplarily, the drug is in the form of tablets, decoctions, powders, pills or granules.

[0102] It should be understood that the pharmaceutically acceptable auxiliary agent used in this embodiment refers to a non-toxic carrier, adjuvant or vehicle that does not destroy the pharmacological activity of the tranquilizing and sleeping-aiding composition formulated together.

[0103] Pharmaceutically acceptable carriers, adjuvants or vehicles that can be used in the composition of this embodiment include, but are not limited to, wetting agents, binders or disintegrants. The types and amounts of the above-mentioned wetting agents, binders or disintegrants should comply with the relevant provisions of the Chinese Pharmacopoeia.

[0104] For example, the disintegrant is selected from one or more of sodium carboxymethylcellulose CMC, CMC-Na, and HPM.

[0105] It should be understood that the above-mentioned adjuvants may be selected in combination with the specific dosage form of the drug.

[0106] The drugs provided in this embodiment can be administered by many routes, including but not limited to: oral administration, parenteral administration, inhalation administration, topical administration or other modes of administration. For example, the drugs used herein are drugs for oral administration or injectable solutions.

[0107] health tea

[0108] The tranquilizing and sleep-inducing composition provided in this embodiment can also be made into health tea. In addition to the tranquilizing and sleep-inducing composition, the health tea can reasonably use other components within the scope that does not significantly damage the effect of the present application. For example: 1-10 parts of taste regulator, preferably 3-8 parts.

[0109] Wherein, the taste regulator is selected from at least one of sucrose, honey, maple syrup, xylitol, stevia and monk fruit sugar.

[0110] It is understandable that the addition of flavor regulators, such as sucrose and honey, can effectively improve the taste of health tea, making it more delicious and increasing consumers' willingness and satisfaction to eat it.

[0111] The above-mentioned flavor modifiers each have a unique sweetness, which can bring a rich and diverse taste experience to the product; for example, the natural sweetness of sucrose and honey can add a mellow feeling to the product, while maple syrup has a unique maple aroma, making the product more distinctive.

[0112] Given that different consumers have different degrees of acceptance and preferences for sweetness, by adding different types of flavor adjusters, health teas suitable for different taste preferences can be produced to meet a wider range of market needs. However, the addition amount and total amount of the above-mentioned additives must comply with relevant regulations.

[0113] The present application will be further described below in conjunction with the examples. It should be understood that these examples are only used to illustrate the present application and are not used to limit the scope of the present application.

[0114] In the following examples, the materials, reagents and instruments used can be purchased from commercial sources unless otherwise specified.

[0115] Examples 1-7

[0116] Examples 1-7 respectively provide a tranquilizing and sleep-aiding composition having the components shown in Table 1, wherein each component in the tranquilizing and sleep-aiding composition is measured by weight.

[0117] Table 1: Composition of the tranquilizing and sleep-aiding compositions of Examples 1-7 (parts by weight)

[0118]

[0119]

[0120] Comparative Example 1-Comparative Example 5

[0121] Comparative Examples 1-5 respectively provide tranquilizing and sleep-aiding compositions having the components shown in Table 2, wherein each component in the tranquilizing and sleep-aiding compositions is measured by weight.

[0122] Table 2: Composition of the tranquilizing and sleep-aiding compositions of Comparative Examples 1-5 (parts by weight)

[0123]

[0124] The preparation method of the tranquilizing and sleeping-aiding composition of Examples 1-7 and Comparative Examples 1-5 comprises the following steps:

[0125] Weigh each component in proportion;

[0126] After drying each component in an oven at 50° C. for 20 min, the components were crushed using a grinder and passed through an 80-mesh sieve, added into a stirring barrel (stirring rate: 850 r / min) and stirred evenly to obtain a tranquilizing and sleep-aiding composition.

[0127] Effect verification

[0128] The above prepared tranquilizing and sleep-aiding composition was subjected to relevant tests, wherein the test contents included tranquilizing and soothing the mind and improving sleep quality.

[0129] Test Method

[0130] Experimental animals: 84 SPF grade KM mice, male, weighing 20-25 g; after 3 days of adaptive feeding in the animal room, the 84 mice were evenly divided into 14 groups, 6 mice in each group, namely a blank control group (using normal saline), a positive drug group (using Yixin Ningshen tablets), Example 1-7 groups (corresponding to the tranquilizing and sleeping compositions of Examples 1-7), and Comparative Example 1-5 groups (corresponding to the tranquilizing and sleeping compositions of Comparative Examples 1-5).

[0131] Among them, for the mice in the positive drug group, Yixin Ningshen tablets were dissolved and dispersed in water, and the dosage of the drug (oral administration) was 1.3g / kg.

[0132] The groups of Examples 1-7 and Comparative Examples 1-5 were administered (orally) with the sedative and sleep-inducing compositions prepared in the corresponding groups; specifically, the sedative and sleep-inducing compositions prepared in each group were soaked in purified water (95°C) at a solid-liquid ratio of 1:60 g / mL, and the residue was filtered after soaking for 6 minutes. After the liquid was cooled to room temperature, it was administered orally at a dosage of 55 mg / kg; the blank control group was administered with the same dose of normal saline. Each group was administered once a day

[0133] The mice in each group were allowed to drink water and eat freely. After 14 consecutive days of gavage, each group was intraperitoneally injected with 40 mg / kg sodium pentobarbital 30 minutes after the last administration, and the sleep latency (min) and sleep time (min) of the mice were observed and recorded.

[0134] Sleep latency is the time from drug administration to loss of righting reflex.

[0135] Sleep was measured by the disappearance of the righting reflex. When the mouse was placed in a dorsal recumbent position, it could turn right immediately. If it could not turn right for more than 1 minute, it was considered that the righting reflex had disappeared and the animal had entered sleep. The recovery of the righting reflex was considered as the animal's awakening, and the time from the disappearance of the righting reflex to the recovery was considered as the animal's sleep time. The test results are shown in Table 3.

[0136] Table 3: Sleep latency and sleep time test results

[0137]

[0138]

[0139] According to the test results in Table 3, the tranquilizing and sleep-aiding compositions of Examples 1-4 can work together from the two aspects of calming the mind (short sleep latency) and improving sleep quality (long sleep time) to improve the tranquilizing and sleep-aiding effect.

[0140] Example 5-7 further adds Chinese date seeds on the basis of Example 3, and has a better effect of calming the nerves and promoting sleep. Among them, the alkaloids and saponins contained in Chinese date seeds can not only have a hypnotic and sedative effect, but also help promote blood circulation in the brain and improve the situation of insufficient blood supply to the brain, thereby achieving the purpose of improving sleep quality.

[0141] Combined with the test results in Table 3, when the Comparative Examples 1 and 4 lacked agarwood leaves or cypress seeds, the sleep latency of Comparative Examples 1 and 4 became longer and the sleep time became shorter compared with Example 3. Among them, the changes in the sleep latency of Comparative Examples 1 and 4 were more significant, indicating that in the tranquilizing and sleep-aiding composition of this embodiment, agarwood leaves or cypress seeds mainly play a sedative and hypnotic role to shorten the sleep latency.

[0142] Specifically, in this embodiment, the active ingredients contained in the cypress seeds can promote the release of GABA in the synaptic cleft and bind to the corresponding receptors, thereby achieving a sedative and tranquilizing effect. At the same time, the agarwood furan contained in the agarwood leaves has good central nervous system sedative and hypnotic activity, and can enhance the function of GABA receptors to exert its sedative and hypnotic effects; therefore, the combination of the cypress seeds and agarwood leaves in this embodiment has a better sedative effect.

[0143] When the Comparative Examples 2 and 5 lack Alpinia oxyphylla or theanine, the sleep latency of the Comparative Examples 2 and 5 becomes longer and the sleep time becomes shorter compared with Example 3. Among them, the changes in the sleep time of Comparative Examples 2 and 5 are more significant, indicating that in the tranquilizing and sleep-aiding composition of this embodiment, Alpinia oxyphylla or theanine is mainly used to improve sleep quality (extend sleep time).

[0144] Specifically, the Alpinia oxyphylla in this embodiment can increase the expression of melatonin receptors, promote brain blood circulation, and thus improve sleep quality; theanine can regulate the balance of brain neurotransmitters, increase the content of substances such as serotonin and dopamine, and promote brain blood circulation, thereby improving sleep quality together with Alpinia oxyphylla. Therefore, the Alpinia oxyphylla and theanine in this embodiment can work together to promote brain blood circulation, thereby significantly improving sleep quality (extending sleep time).

[0145] Further comparing Example 3 and Comparative Example 3, Comparative Example 3 did not add Polygonum multiflorum; According to the test results of Table 3, compared with Example 3, the sleep latency of Comparative Example 3 is longer and the sleep time is shorter. Among them, the sleep latency and sleep time of Comparative Example 3 both showed significant changes, indicating that in the tranquilizing and sleep-aiding composition of this embodiment, Polygonum multiflorum not only has a calming and tranquilizing effect, but also can nourish blood, improve blood circulation, and is conducive to improving sleep quality (extending sleep time).

[0146] Therefore, in the tranquilizing and sleep-aiding composition of this embodiment, the combination of cypress seeds and agarwood leaves has a better sedative effect (shortening the sleep latency period), and the Alpinia oxyphylla can promote blood circulation in the brain together with theanine, thereby better improving the sleep quality (extending the sleep time); on this basis, Polygonum multiflorum has both the effects of tranquilizing and calming the mind and improving the sleep quality, thereby not only improving the sedative effect of the tranquilizing and sleep-aiding composition (shortening the sleep latency period), but also further improving the sleep quality (extending the sleep time).

[0147] In summary, the tranquilizing and sleep-aiding composition of this embodiment can work together from two aspects: calming the mind (shortening sleep latency) and improving sleep quality (extending sleep time), so as to improve the tranquilizing and sleep-aiding effect.

[0148] The technical solution provided by the present application is introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only applicable to help understand the principles of the present application. At the same time, for general technical personnel in this field, according to the present application, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A tranquilizing and sleep-inducing composition containing agarwood leaves, characterized in that: The tranquilizing and sleeping-aiding composition comprises, by weight: Agarwood leaves: 10-18 parts; Alpinia oxyphylla kernel: 5-12 portions; Polygonum multiflorum: 8-16 parts; Pineapple seeds: 8-16 servings; Theanine: 3-7 parts.

2. The tranquilizing and sleeping-aiding composition according to claim 1, characterized in that: The tranquilizing and sleeping-aiding composition comprises, by weight: Agarwood leaves: 14-16 parts; Alpinia oxyphylla kernel: 6-8 portions; Polygonum multiflorum: 12-16 parts; Pine nuts: 8-10 portions; Theanine: 4-6 parts.

3. The tranquilizing and sleeping-aiding composition according to claim 1 or 2, characterized in that: The tranquilizing and sleeping-aiding composition further comprises, by weight: Chinese date seeds: 3-6 servings.

4. The tranquilizing and sleeping-aiding composition according to claim 3, characterized in that: The tranquilizing and sleeping-aiding composition comprises, by weight: Chinese date seeds: 4-6 servings.

5. A method for preparing the sedative and sleep-inducing composition containing agarwood leaves as claimed in any one of claims 1 to 4, characterized in that: The preparation method comprises: Weigh each component in proportion; The components are mixed evenly to obtain a tranquilizing and sleep-aiding composition.

6. The preparation method according to claim 5, characterized in that: The components are mixed evenly to obtain a tranquilizing and sleep-aiding composition, comprising: The components are dried and crushed, and then passed through a 60-80 mesh sieve and mixed evenly to obtain a tranquilizing and sleep-aiding composition.

7. Use of the tranquilizing and sleeping-aiding composition containing agarwood leaves according to any one of claims 1 to 4 in the preparation of a medicament for preventing or treating insomnia symptoms.

8. The use according to claim 7, characterized in that The medicament further includes a pharmaceutically acceptable adjuvant.

9. A health tea, characterized in that: The health tea comprises the agarwood leaf-containing tranquilizing and sleep-aiding composition according to any one of claims 1 to 4.

10. The health tea according to claim 9, characterized in that: The health tea also includes: 1-10 parts of taste regulator; The taste regulator is selected from at least one of sucrose, honey, maple syrup, xylitol, stevia and monk fruit sugar.

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