A preparation device and method of active biological calcium particles based on embrittlement resonance

Abstract

The present invention provides a preparation device and method of active biological calcium particles based on embrittlement resonance, which relates to the technical field of calcium particle preparation. The preparation device includes: a bone particle cooling sealed cylinder, a liquid nitrogen cooler, a liquid nitrogen circulation pipeline, a bone particle transmission pipeline, a resonator and a particle filter; the bone particle cooling sealed cylinder is provided with a feed port; the liquid nitrogen cooler is provided with a nitrogen inlet and a nitrogen outlet, and the nitrogen inlet and the nitrogen outlet are connected through a liquid nitrogen circulation pipeline; at least part of the liquid nitrogen circulation pipeline passes through the inside of the bone particle cooling sealed cylinder; the bone particle cooling sealed cylinder is connected to the resonator through the bone particle transmission pipeline; the resonator is connected to the particle filter; the particle filter is provided with a discharge port and a waste port. The present invention can cool and embrittle the coarse particles obtained by the traditional research and development method in the bone particle cooling sealed cylinder, and then crush them through the resonator to obtain finer particles, thereby improving the human body absorption rate of calcium particles.

Description

Technical Field

[0001] The invention relates to the technical field of calcium particle preparation, and in particular to a device and method for preparing active biological calcium particles based on embrittlement resonance. Background Art

[0002] Calcium is an important element for the human body. 99% of the calcium in the human body is stored in bones and teeth. Generally speaking, the body absorbs calcium faster than it loses it before the age of 35, and loses it faster than it absorbs it after the age of 35. As calcium is lost, symptoms such as "osteoporosis" will appear. In order to alleviate these symptoms, it is necessary to supplement some calcium-rich foods or drugs, so various calcium tablets came into being.

[0003] Currently, the preparation methods of calcium tablets include chemical methods and physical methods.

[0004] The chemical method uses calcium carbonate (the main component of limestone) as the main raw material and other compounds to react with the embrittlement agent to obtain a mixture mainly composed of hydroxyapatite, which is then purified. Calcium tablets prepared by chemical methods, no matter how high the purity, contain other substances that are not needed by the human body or are harmful to the human body. Because they are made of minerals, they do not have biological activity that combines with the human body.

[0005] The physical method uses calcium-rich organic matter such as animal bones, corals or shells to obtain fine particles through physical methods such as crushing and grinding, and then makes calcium tablets from the fine particles. Currently, the particle size prepared by physical methods can only reach 100 nanometers, and the human body has a low absorption rate. Summary of the invention

[0006] In order to solve the technical problem that the active biological calcium particles prepared by physical methods in the prior art can only reach 100 nanometers and have low absorption rate by the human body, the present invention provides a preparation device and method of active biological calcium particles based on embrittlement resonance.

[0007] The technical solution provided by the embodiment of the present invention is as follows:

[0008] First aspect:

[0009] An embodiment of the present invention provides a preparation device for active biological calcium particles based on embrittlement resonance, comprising: a bone particle cooling sealing cylinder, a liquid nitrogen cooler, a liquid nitrogen circulation pipeline, a bone particle transmission pipeline, a resonator and a particle filter;

[0010] The bone particle cooling sealing cylinder is provided with a feed inlet;

[0011] The liquid nitrogen cooler is provided with a nitrogen inlet and a nitrogen outlet, and the nitrogen inlet and the nitrogen outlet are connected through the liquid nitrogen circulation pipeline;

[0012] At least a portion of the liquid nitrogen circulation pipeline passes through the bone particles to cool the interior of the sealed cylinder;

[0013] The bone particle cooling sealing cylinder is connected to the resonator through the bone particle conveying pipeline;

[0014] The resonator is connected to the particle filter;

[0015] The particle filter is provided with a discharge port and a waste port.

[0016] Second aspect:

[0017] A method for preparing active biological calcium particles based on embrittlement resonance provided by an embodiment of the present invention is applied to the device for preparing active biological calcium particles based on embrittlement resonance described in the first aspect, comprising:

[0018] S1: Grind animal bones into bone particles by traditional grinding method;

[0019] S2: feeding the bone particles into the bone particle cooling sealing cylinder through the feed port;

[0020] S3: generating a gas-liquid mixture of nitrogen in a thick state through the liquid nitrogen cooler, and the gas-liquid mixture forms a self-circulating system through the liquid nitrogen circulation pipeline;

[0021] S4: the liquid nitrogen circulation pipeline performs heat exchange with the bone particles in the bone particle cooling sealed cylinder to perform cooling and embrittlement treatment on the bone particles;

[0022] S5: inputting the cooled and brittle bone particles into the resonator for crushing;

[0023] S6: The crushed bone particles are input into the particle filter for filtration, the bone particles larger than or equal to the preset size are discharged from the waste port, and the bone particles smaller than the preset size are discharged from the discharge port to prepare nano-scale active biological calcium particles.

[0024] The beneficial effects brought about by the technical solution provided by the embodiment of the present invention include at least:

[0025] In the present invention, the coarse particles obtained by the traditional research and development method can be cooled and embrittled in the bone particle cooling and sealing cylinder, and then crushed by a resonator to obtain finer particles, thereby improving the human body absorption rate of the calcium particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0027] Figure 1 A schematic structural diagram of a device for preparing active biological calcium particles based on embrittlement resonance provided in an embodiment of the present invention;

[0028] Figure 2 A schematic flow chart of a method for preparing active biological calcium particles based on embrittlement resonance provided in an embodiment of the present invention.

[0029] [Reference Signs]

[0030] 1. Bone particle cooling sealing cylinder; 11. Feed port; 2. Liquid nitrogen cooler; 3. Liquid nitrogen circulation pipeline; 4. Bone particle transmission pipeline; 5. Resonator; 51. Primary resonator; 52. Secondary resonator; 53. Third-stage resonator; 6. Particle filter; 61. Discharge port; 62. Waste port. DETAILED DESCRIPTION

[0031] The following is a detailed description of a preparation device for active biological calcium particles based on embrittlement resonance provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0032] It should be noted that the references to "one embodiment", "an embodiment", "an exemplary embodiment", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0033] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0034] In order to make the technical problems, technical solutions and advantages to be solved by the present invention more clear, a detailed description will be given below with reference to the accompanying drawings and specific embodiments.

[0035] Reference Manual Attached Figure 1 , showing a schematic structural diagram of a device for preparing active biological calcium particles based on embrittlement resonance provided in an embodiment of the present invention.

[0036] An embodiment of the present invention provides a device for preparing active biological calcium particles based on embrittlement resonance, including: a bone particle cooling sealing cylinder 1, a liquid nitrogen cooler 2, a liquid nitrogen circulation pipeline 3, a bone particle transmission pipeline 4, a resonator 5 and a particle filter 6.

[0037] The bone particle cooling sealing cylinder 1 is provided with a feed inlet 11 .

[0038] The liquid nitrogen cooler 2 is provided with a nitrogen inlet and a nitrogen outlet, and the nitrogen inlet and the nitrogen outlet are connected through a liquid nitrogen circulation pipeline 3.

[0039] At least a portion of the liquid nitrogen circulation pipeline 3 passes through the interior of the bone particle cooling sealed cylinder 1. By arranging a portion of the liquid nitrogen circulation pipeline 3 inside the bone particle cooling sealed cylinder 1, the liquid nitrogen can directly exchange heat with the bone particles, quickly cooling the particles to an extremely low temperature, which can effectively embrittle the bone particles, making them more fragile and convenient for subsequent crushing processing.

[0040] The bone particle cooling sealed cylinder 1 is connected to the resonator 5 through the bone particle conveying pipeline 4. The bone particles that have been cooled and embrittled are crushed in the resonator 5, becoming more fragile and easily reaching the nanometer level.

[0041] The resonator 5 is connected to the particle filter 6. The particle filter 6 is provided with a discharge port 61 and a waste port 62. The crushed particles then enter the particle filter 6 for screening. The particle filter 6 separates the particles according to the particle size, discharges the nanoparticles that meet the requirements from the discharge port 61, and discharges the larger particles that do not meet the requirements from the waste port 62 for further processing or disposal.

[0042] The particle filter 6 is provided with multiple filter screens. The multiple filter screens can filter in layers according to the particle size, and each layer of filter screen is responsible for filtering the particle size within a specific range. This layer-by-layer screening method can improve the screening accuracy and ensure that the final product contains only nano-scale particles that meet the preset size requirements.

[0043] In the present invention, multiple steps of cooling, crushing and screening are integrated to form a continuous, efficient and closed production process, which greatly improves the production efficiency and product quality of nano-scale active biological calcium particles.

[0044] In a possible implementation, the resonator 5 includes a primary resonator 51, a secondary resonator 52 and a tertiary resonator 53. The primary resonator 51, the secondary resonator 52 and the tertiary resonator 53 are connected in series. The bone particle cooling sealing cylinder 1 is connected to the primary resonator 51 through the bone particle conveying pipeline 4. The tertiary resonator 53 is connected to the particle filter 6.

[0045] It should be noted that the primary resonator 51 can decompose bone particles with low density, the secondary resonator 52 can decompose bone particles with medium density, and the tertiary resonator 53 can decompose bone particles with high density.

[0046] In the present invention, bone particles of different densities are processed separately in resonators with different resonant frequencies. The first-stage resonator processes particles with lower density, the second-stage resonator processes particles with medium density, and the third-stage resonator processes particles with higher density. This graded processing can more accurately control the pulverization process, so that each type of particle can obtain the best pulverization effect under appropriate conditions, avoiding excessive or insufficient pulverization.

[0047] In a possible implementation manner, the resonance frequency of the primary resonator 51 is 190 Hz.

[0048] In a possible implementation, the resonance frequency of the secondary resonator 52 is 200 Hz.

[0049] In a possible implementation manner, the resonance frequency of the three-stage resonator 53 is 210 Hz.

[0050] In a possible implementation, the liquid nitrogen cooler 2 pressurizes the nitrogen to 4 MPa and cools it to -150°C. The nitrogen is in a thick gas-liquid mixture, and the gas-liquid mixture forms a self-circulating system through the liquid nitrogen circulation pipeline 3.

[0051] In one possible implementation, the liquid nitrogen circulation pipeline performs heat exchange with the bone particles in the bone particle cooling sealed cylinder to cool the bone particles to a temperature range of -100°C to -150°C, thereby performing cooling and embrittlement treatment on the bone particles.

[0052] After research, it was found that at room temperature, collagen is connected by multiple proteins and polysaccharides, and the van der Waals force between molecules makes it difficult for hydroxyapatite to be decomposed by physical methods. Through our research, we found that the connection force between collagen in animal bones is greatly reduced in an environment of -150°C, and a "brittle" phenomenon occurs. When animal bones are at -150°C, their natural frequency range is: 192Hz to 220Hz, depending on their different bone types. The frequency of the skull is the highest and the frequency of the cartilage is the lowest. In an environment of -150°C, by applying external force to animal bones in the frequency range of 192Hz to 220Hz for frequency resonance, hydroxyapatite particles with a diameter range of 1 to 10nm can be obtained.

[0053] In the present invention, by crushing bones in a low-temperature environment through resonance technology, the target substance (such as hydroxyapatite) can be separated more accurately, and the generation and mixing of impurities can be reduced, which not only improves the purity of the product, but also enhances the biological activity and absorption effect of the biological calcium particles.

[0054] In a possible embodiment, the particle filter 6 is used to discharge bone particles greater than or equal to a preset size from the waste port 62, and to discharge bone particles smaller than the preset size from the discharge port 61, so as to prepare nano-scale active biological calcium particles.

[0055] In a possible implementation manner, the preset size is specifically 10 nm.

[0056] It should be noted that by setting a clear particle size threshold (such as 10nm), it can be ensured that the particle size of the final nano-scale active biological calcium particles is within the desired range. This can improve the uniformity of the product and ensure that each batch of particles has consistent physical and chemical properties, thereby improving product quality.

[0057] In the present invention, the particle filter is designed to screen according to a preset size, which helps to improve the quality consistency, bioavailability and market competitiveness of nano-scale active biological calcium particles, while optimizing resource utilization to meet the needs of specific applications.

[0058] The beneficial effects brought about by the technical solution provided by the embodiment of the present invention include at least:

[0059] In the present invention, the coarse particles obtained by the traditional research and development method can be cooled and embrittled in a bone particle cooling sealing cylinder, and then crushed by a resonator to obtain finer particles, thereby improving the human body absorption rate of the calcium particles.

[0060] Reference Manual Attached Figure 2 , showing a schematic flow chart of a method for preparing active biological calcium particles based on embrittlement resonance provided by the present invention.

[0061] The present invention also provides a method for preparing active biological calcium particles based on embrittlement resonance, which is applied to the above-mentioned device for preparing active biological calcium particles based on embrittlement resonance, comprising:

[0062] S1: Grind animal bones into bone particles by traditional grinding method.

[0063] S2: The bone particles are fed into the bone particle cooling sealing cylinder through the feed port.

[0064] S3: A liquid nitrogen cooler generates a thick gas-liquid mixture of nitrogen, and the gas-liquid mixture forms a self-circulating system through a liquid nitrogen circulation pipeline.

[0065] S4: The liquid nitrogen circulation pipeline exchanges heat with the bone particles in the bone particle cooling sealed cylinder to cool and embrittle the bone particles.

[0066] S5: The cooled and brittle bone particles are input into the resonator for crushing.

[0067] S6: The crushed bone particles are input into a particle filter for filtration, the bone particles larger than or equal to a preset size are discharged from a waste port, and the bone particles smaller than the preset size are discharged from a discharge port, so as to prepare nano-scale active biological calcium particles.

[0068] The beneficial effects brought about by the technical solution provided by the embodiment of the present invention include at least:

[0069] In the present invention, the coarse particles obtained by the traditional research and development method can be cooled and embrittled in the bone particle cooling and sealing cylinder, and then crushed by a resonator to obtain finer particles, thereby improving the human body absorption rate of the calcium particles.

[0070] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0071] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A preparation device for active biological calcium particles based on embrittlement resonance, characterized in that: include: Bone particle cooling sealed cylinder, liquid nitrogen cooler, liquid nitrogen circulation pipeline, bone particle transmission pipeline, resonator and particle filter; The bone particle cooling sealing cylinder is provided with a feed inlet; The liquid nitrogen cooler is provided with a nitrogen inlet and a nitrogen outlet, and the nitrogen inlet and the nitrogen outlet are connected through the liquid nitrogen circulation pipeline; At least a portion of the liquid nitrogen circulation pipeline passes through the bone particles to cool the interior of the sealed cylinder; The bone particle cooling sealing cylinder is connected to the resonator through the bone particle conveying pipeline; The resonator is connected to the particle filter; The particle filter is provided with a discharge port and a waste port; Wherein, the resonator includes a primary resonator, a secondary resonator and a tertiary resonator; The primary resonator, the secondary resonator and the tertiary resonator are connected in series; The bone particle cooling sealing cylinder is connected to the primary resonator through the bone particle transmission pipeline; The third-stage resonator is connected to the particle filter; Wherein, the resonance frequency of the primary resonator is 190 Hz; Wherein, the resonant frequency of the secondary resonator is 200 Hz; Wherein, the resonance frequency of the three-stage resonator is 210 Hz.

2. The device for preparing active biological calcium particles based on embrittlement resonance according to claim 1, characterized in that: The liquid nitrogen cooler pressurizes nitrogen to 4MPa and cools it to -150°C. The nitrogen is in a thick gas-liquid mixture, and the gas-liquid mixture forms a self-circulating system through the liquid nitrogen circulation pipeline.

3. The preparation device of active biological calcium particles based on embrittlement resonance according to claim 2 is characterized in that: The liquid nitrogen circulation pipeline performs heat exchange with the bone particles in the bone particle cooling sealing cylinder, cools the bone particles to a temperature range of -100°C to -150°C, and performs cooling and embrittlement treatment on the bone particles.

4. The preparation device of active biological calcium particles based on embrittlement resonance according to claim 1, characterized in that: The particle filter is used to discharge bone particles larger than or equal to a preset size from the waste port, and to discharge bone particles smaller than the preset size from the discharge port, thereby preparing nano-scale active biological calcium particles.

5. The device for preparing active biological calcium particles based on embrittlement resonance according to claim 4, characterized in that: The preset size is specifically 10 nm.

6. A method for preparing active biological calcium particles based on embrittlement resonance, applied to the device for preparing active biological calcium particles based on embrittlement resonance according to any one of claims 1 to 5, characterized in that: include: S1: Grind animal bones into bone particles by traditional grinding method; S2: feeding the bone particles into the bone particle cooling sealing cylinder through the feed port; S3: generating a gas-liquid mixture of nitrogen in a thick state through the liquid nitrogen cooler, and the gas-liquid mixture forms a self-circulating system through the liquid nitrogen circulation pipeline; S4: the liquid nitrogen circulation pipeline performs heat exchange with the bone particles in the bone particle cooling sealed cylinder to perform cooling and embrittlement treatment on the bone particles; S5: inputting the cooled and brittle bone particles into the resonator for crushing; S6: The crushed bone particles are input into the particle filter for filtration, the bone particles larger than or equal to the preset size are discharged from the waste port, and the bone particles smaller than the preset size are discharged from the discharge port to prepare nano-scale active biological calcium particles.

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