Mongolian medicine patch for treating skin wounds and preparation method thereof

Abstract

The invention belongs to the technical field of Mongolian medicines, and particularly relates to a Mongolian medicine patch for treating skin wounds and a preparation method of the Mongolian medicine patch. The Mongolian medicine patch comprises ointment and a patch, the ointment is prepared from the following raw materials in parts by weight: 35-40 parts of gypsum rubrum, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of vermilion, 5-8 parts of concha haliotidis and 0.5-1 part of musk; adding auxiliary materials and blending into paste; the patch is soft cloth, the ointment is smeared on the patch, and the Mongolian medicine patch applied to the skin wound is prepared. The ointment formula of the Mongolian medicine patch is good in skin wound treatment effect, high in speed and free of side effects.

Description

Technical Field

[0001] The invention belongs to the technical field of Mongolian medicine, and particularly relates to a Mongolian medicine patch for treating skin wounds and a preparation method thereof. Background Art

[0002] There are many reasons for skin wounds, such as knife wounds, carbuncles, etc. Regardless of the cause, it will cause skin ulcers and wounds, and in severe cases, it may cause tissue infection. Since the skin is the first immune barrier, rapid wound healing is a common demand. Small side effects are also a common demand. At present, common wound treatment drugs include alcohol, iodine, excipients, etc., which are mainly anti-inflammatory and analgesic. However, the drug effect is slow and it takes a long time for the wound to heal.

[0003] Mongolian medicine has certain regional characteristics and is adapted to geographical conditions and resources. The Mongolian medicine theory system is a unique medicine theory system that absorbs the essence of various medical theories such as Tibetan Buddhist medicine and traditional Chinese medicine theory. Mongolian medicine has strong medicinal properties and few side effects. Therefore, it is necessary to develop a Mongolian medicine suitable for skin wound treatment. Summary of the invention

[0004] In order to utilize the advantages of Mongolian medicine with strong medicinal properties and few side effects and to accelerate the healing of skin wounds, the present invention provides a Mongolian medicine patch for treating skin wounds and a preparation method thereof.

[0005] The purpose of the present invention is to provide a Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0006] The ointment is prepared from the following raw materials in parts by weight: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk; auxiliary materials are added to make a paste;

[0007] The patch is made of soft cloth;

[0008] The ointment is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0009] It should be noted that the Chinese medicinal materials used to prepare the above-mentioned ointment should comply with national standards and be medicinal materials that can be used as medicine. The medicinal materials used in the experiments of the present invention were purchased from suppliers of Chinese medicinal materials that can be used as medicine directly.

[0010] In the above ointment formula, the effects of each medicinal material are as follows:

[0011] Hanshuishi: It is a mineral Chinese medicinal material, which can clear away heat and purge fire. It is pungent and dispersing, cold in nature, and belongs to the heart, stomach, and kidney meridians. It can be harvested all year round and ground into powder for use. It has therapeutic effects on oral sores, herpes simplex, and heat-toxic sores and swelling. The powder is used externally for wind-heat eyes, sore throat, oral sores, burns, and other diseases, and for treating poisonous sores.

[0012] Borneol: Borneol is pungent and fragrant, can open all the orifices and relieve pain, enter the heart meridian and relieve pain, can be used for chest pain, enter the tendons and bones and relieve pain, and can also be used for injuries and tendons and bone pain. Borneol has the effect of relieving pain and antiseptic, and can clear away heat, relieve itching, and promote tissue regeneration when used externally.

[0013] Realgar: It has antibacterial and antiviral effects, and can detoxify, kill insects and relieve itching.

[0014] Cinnabar: "Ben Jing": "It cures all diseases of the five internal organs, nourishes the spirit, calms the soul, and improves qi and eyesight." "Ming Yi Bie Lu": "It clears the blood vessels, stops irritability, relieves thirst, improves the spirit, brightens the face, eliminates abdominal pain, toxic gas, scabies, fistulas and other sores." "Compendium of Materia Medica Volume 9": "It cures epilepsy, resolves fetal toxins, pox toxins, and drives away evil spirits and malaria." Cinnabar has the effects of clearing the heart, calming the mind, improving eyesight and detoxifying.

[0015] Vermilion: It enters the heart and lung meridians, has the effects of removing phlegm and dampness, killing viruses and insects, and can be used to treat a variety of skin diseases. When used externally, Vermilion has a good therapeutic effect on carbuncle, wet sore, scabies, swelling, and ulcers.

[0016] Lithospermum officinale: Lithospermum officinale was first recorded in "Ming Yi Bie Lu": "Lithospermum officinale, salty and flat in taste, non-toxic. Indications: eye obstruction, cataract, amblyopia. Long-term use can improve essence and lighten the body. Grown in the South China Sea." In the present invention, the main effects of Lithospermum officinale are calming the liver and suppressing yang, clearing the liver and improving eyesight.

[0017] Musk: According to Ben Jing, musk is “used to ward off evil spirits, kill ghosts, malaria, poison, epilepsy, and remove three kinds of worms… taking it for a long time can eliminate evil spirits, and prevent dreams and nightmares.” According to Ming Yi Bie Lu, musk is “used to treat all kinds of evil spirits, evil spirits, sudden pain in the heart and abdomen, bloating, wind poison, and difficult childbirth and abortion.” In the present invention, musk has the effects of opening the mind, activating blood circulation, dredging menstruation, and reducing swelling and relieving pain.

[0018] The ointment of the present invention is a brand-new formula, which calls for suitable Chinese medicinal materials. The compatibility principle of the ointment formula of the present invention is as follows:

[0019] Han Shui Shi is the main ingredient, mainly used to treat poisonous sores; borneol is the secondary ingredient, which can relieve pain; realgar, cinnabar, vermilion and stone cassia are the adjuvants, which cooperate with the main and secondary ingredients to treat diseases; musk is the guiding ingredient, which can promote blood circulation and unblock meridians, and harmonize all the ingredients.

[0020] In some embodiments, the auxiliary material is a mixture of sesame oil and 60% ethanol by volume, such as a volume ratio of sesame oil to 60% ethanol of 1-2:100, more specifically, a volume ratio of sesame oil to 60% ethanol of 1:100, a volume ratio of sesame oil to 60% ethanol of 1.5:100, or a volume ratio of sesame oil to 60% ethanol of 2:100.

[0021] In some embodiments, the ointment is made of the following raw materials in parts by weight: 35 parts of cold water stone, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk. This is the best ointment formula with the best efficacy.

[0022] Based on the same inventive concept, the present invention also provides a method for preparing a Mongolian medicine patch for treating skin wounds, comprising:

[0023] (1) Preparation of paste

[0024] Prepare the powder of each Chinese medicinal material according to the following weight proportions: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk;

[0025] The powder particle size of each Chinese medicinal material is 150-200 mesh, such as 150 mesh, 180 mesh, and 200 mesh;

[0026] The above raw material powders are mixed evenly, and auxiliary materials are added to form a paste to obtain a paste-like ointment;

[0027] (2) The paste is applied on the patch to make a Mongolian medicine patch for application on the skin wound.

[0028] After the paste is applied to the patch, the thickness of the paste is 1-2 mm.

[0029] Based on the same inventive concept, the present invention also provides a method for preparing a Mongolian medicine patch for treating skin wounds, comprising:

[0030] (1) Preparation of paste

[0031] Prepare the powder of each Chinese medicinal material according to the following weight proportions: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk;

[0032] The powder particle size of each Chinese medicinal material is 150-200 mesh, such as 150 mesh, 180 mesh, and 200 mesh;

[0033] The raw material powders are mixed evenly and divided into two materials of 1 / 10 and 9 / 10 weight. The 1 / 10 weight is recorded as material A, and the 9 / 10 weight is recorded as material B.

[0034] Material A is mixed with the extraction solvent, and the mixture is allowed to stand for extraction for 1-2 hours, filtered, the Chinese medicine residue is discarded, the filtrate is collected, concentrated into an extract, and dried for later use;

[0035] After material B is fully mixed with the dried extract, auxiliary materials are added to form a paste to obtain a paste ointment;

[0036] (2) The paste is applied on the patch to make a Mongolian medicine patch for application on the skin wound.

[0037] After the paste is applied to the patch, the thickness of the paste is 1-2 mm.

[0038] It should be noted that in any of the above-mentioned methods for preparing Mongolian medicine patches, the paste is in a viscous state. After the paste is applied on the patch, the thickness is 1-2 mm. When the patch is picked up vertically, the paste does not flow within 10 seconds.

[0039] Preferably, in the preparation method of the Mongolian medicine patch for treating skin wounds, when material A is mixed with the extraction solvent, the solvent used is a mixture of 60% by volume ethanol and disodium ethylenediaminetetraacetate, wherein the volume ratio of 60% ethanol to disodium ethylenediaminetetraacetate is 100:0.5-1.

[0040] The mass ratio of material A to extraction solvent is 1:6-8.

[0041] The main active ingredient in the extract is d-borneol.

[0042] The main component of calcite is calcium carbonate, which is a substance that is difficult to dissolve in water. Calcite also contains magnesium and iron elements. The present invention uses a mixed solution of 60% ethanol and disodium ethylenediaminetetraacetic acid as a solvent to chelate these metal elements, which are absorbed by the patient's wound surface to enhance the therapeutic effect. The main active ingredient of borneol, d-borneol, is a substance that is easily soluble in the mixed solution of 60% ethanol and disodium ethylenediaminetetraacetic acid described in the present invention. The present invention uses the extraction solvent to improve the extraction efficiency of d-borneol.

[0043] In a preparation method of a Mongolian medicine patch of the present invention, a mixture of Chinese medicinal material powder is divided into material A and material B, and the solvent of the present invention can first extract some effective ingredients in material A, and these effective ingredients directly act on the wound surface; while material B is mixed with auxiliary materials and extracts, and material B has not been extracted by an extractant, so when the Mongolian medicine patch of the present invention is applied on the wound surface, the effective ingredients in material B are first dissolved in the auxiliary materials, and then absorbed by the wound surface, which is sustained release. In summary, the separate treatment methods of material A and material B make the patch contain both substances that can directly act on the wound surface and substances that slowly release the wound surface, which is faster and more durable than the traditional patch.

[0044] In some technical solutions, the patch is square with a side length of 5 cm, and the plaster layer is square with a side length of 3 cm.

[0045] In some technical solutions, the patch is square with a side length of 10 cm, and the plaster layer is square with a side length of 6 cm.

[0046] Compared with the prior art, the present invention has the following beneficial effects:

[0047] One of the innovative points of the present invention is to provide a Mongolian medicine plaster formula, wherein cold water stone is used as the main ingredient to treat poisonous sores, borneol is used as the secondary ingredient to relieve pain, realgar, cinnabar, silver vermilion and stone cassia seed are not adjuvants, and the main ingredient and the secondary ingredient are used to treat the disease, and musk is used as the adjuvant to promote blood circulation and dredge collaterals and harmonize the various ingredients. The medicine has good efficacy, fast curative effect and no side effects.

[0048] The second innovation of the present invention is to provide a new method for making an ointment, wherein the mixture of Chinese medicinal material powder is divided into material A and material B, and the solvent can first extract some effective ingredients in material A, which can directly act on the wound surface; while material B is mixed with auxiliary materials and extracts, and has not been extracted by an extractant, so when the Mongolian medicine patch of the present invention is applied to the wound surface, the effective ingredients in material B are first dissolved in the auxiliary materials, and then absorbed by the wound surface, which is a sustained release. Therefore, the patch prepared by the present invention exerts a faster and more lasting drug effect than the traditional patch.

[0049] The third innovative point of the present invention is that a larger amount of effective substances, such as a larger amount of d-borneol, is extracted by using a mixture of 60% ethanol and disodium ethylenediaminetetraacetic acid as an extraction solvent. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 This is a diagram showing the effect of the Mongolian medicine patch prepared in Example 1 of the present invention on treating carbuncle;

[0051] A is the carbuncle before treatment, and B is the skin after treatment. Comparing A and B, we can see that the carbuncle has been cured without leaving any side effects such as scars. DETAILED DESCRIPTION

[0052] In order to enable those skilled in the art to better understand and implement the technical solution of the present invention, the present invention is further described below in conjunction with specific embodiments and drawings.

[0053] In the description of the present invention, unless otherwise specified, all reagents used are commercially available and all methods used are conventional techniques in the art.

[0054] Example 1

[0055] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0056] The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk; auxiliary materials are added to make a paste;

[0057] The patch is made of soft cloth;

[0058] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0059] The specific preparation method of Mongolian medicine patch is as follows:

[0060] (1) Preparation of paste

[0061] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk;

[0062] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0063] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0064] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0065] (2) Prepare the patch

[0066] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0067] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0068] Example 2

[0069] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0070] The ointment is prepared from the following raw materials in parts by weight: 38 parts of calcite, 28 parts of borneol, 12 parts of realgar, 8 parts of cinnabar, 6 parts of silver vermilion, 6 parts of stone cassia seed, and 0.8 parts of musk; auxiliary materials are added to make a paste;

[0071] The patch is made of soft cloth;

[0072] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0073] The specific preparation method of Mongolian medicine patch is as follows:

[0074] (1) Preparation of paste

[0075] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 38 parts of calcite, 28 parts of borneol, 12 parts of realgar, 8 parts of cinnabar, 6 parts of vermilion, 6 parts of stone cassia, and 0.8 parts of musk;

[0076] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0077] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0078] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0079] (2) Prepare the patch

[0080] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0081] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0082] Example 3

[0083] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0084] The ointment is prepared from the following raw materials in parts by weight: 40 parts of calcite, 30 parts of borneol, 15 parts of realgar, 10 parts of cinnabar, 8 parts of silver vermilion, 8 parts of stone cassia seed, and 1 part of musk; auxiliary materials are added to make a paste;

[0085] The patch is made of soft cloth;

[0086] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0087] The specific preparation method of Mongolian medicine patch is as follows:

[0088] (1) Preparation of paste

[0089] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 40 parts of calcite, 30 parts of borneol, 15 parts of realgar, 10 parts of cinnabar, 8 parts of silver vermilion, 8 parts of stone cassia seed, and 1 part of musk;

[0090] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0091] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0092] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0093] (2) Prepare the patch

[0094] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0095] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0096] For ease of reading, the formula differences of Examples 1-3 are summarized in the following Table 1. Except for the formula differences, other operations of Examples 1-3 are the same.

[0097] Table 1 Differences in Chinese medicine raw materials in each example

[0098] Example 1 Example 2 Example 3 Cold water stone (unit) 35 38 40 Borneol (portion) 25 28 30 Realgar (portion) 10 12 15 Cinnabar (part) 5 8 10 Silver Vermillion (Piece) 5 6 8 Semen Cassiae (portion) 5 6 8 Musk (part) 0.5 0.8 1

[0099] Example 4

[0100] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0101] The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk; auxiliary materials are added to make a paste;

[0102] The patch is made of soft cloth;

[0103] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0104] The specific preparation method of Mongolian medicine patch is as follows:

[0105] (1) Preparation of paste

[0106] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk;

[0107] The powder particle size of each Chinese herbal medicine is 150 mesh;

[0108] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0109] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0110] (2) Prepare the patch

[0111] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0112] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0113] Example 5

[0114] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0115] The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk; auxiliary materials are added to make a paste;

[0116] The patch is made of soft cloth;

[0117] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0118] The specific preparation method of Mongolian medicine patch is as follows:

[0119] (1) Preparation of paste

[0120] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk;

[0121] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0122] The raw material powders are mixed evenly and divided into two materials of 1 / 10 and 9 / 10 weight. The 1 / 10 weight is recorded as material A, and the 9 / 10 weight is recorded as material B.

[0123] Material A was mixed with the extraction solvent, and allowed to stand for extraction for 1 h. The mixture was filtered through a 250-mesh filter, the Chinese medicinal residue was discarded, the filtrate was collected, concentrated into an extract, dried, and made into a 200-mesh powder for later use;

[0124] The solvent used is a mixture of 60% ethanol and disodium ethylenediaminetetraacetate by volume, wherein the volume ratio of 60% ethanol to disodium ethylenediaminetetraacetate is 100:0.5; the mass ratio of material A to the extraction solvent is 1:6;

[0125] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0126] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0127] (2) Prepare the patch

[0128] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0129] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0130] Example 6

[0131] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0132] The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk; auxiliary materials are added to make a paste;

[0133] The patch is made of soft cloth;

[0134] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0135] The specific preparation method of Mongolian medicine patch is as follows:

[0136] (1) Preparation of paste

[0137] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk;

[0138] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0139] The raw material powders are mixed evenly and divided into two materials of 1 / 10 and 9 / 10 weight. The 1 / 10 weight is recorded as material A, and the 9 / 10 weight is recorded as material B.

[0140] Material A was mixed with the extraction solvent, and allowed to stand for extraction for 1 h. The mixture was filtered through a 250-mesh filter, the Chinese medicinal residue was discarded, the filtrate was collected, concentrated into an extract, dried, and made into a 200-mesh powder for later use;

[0141] The solvent used is a mixture of 60% ethanol and disodium ethylenediaminetetraacetate by volume, wherein the volume ratio of 60% ethanol to disodium ethylenediaminetetraacetate is 100:1; the mass ratio of material A to the extraction solvent is 1:6;

[0142] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0143] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0144] (2) Prepare the patch

[0145] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0146] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0147] Example 7

[0148] A Mongolian medicine patch for treating skin wounds, including an ointment and a patch;

[0149] The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk; auxiliary materials are added to make a paste;

[0150] The patch is made of soft cloth;

[0151] The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

[0152] The specific preparation method of Mongolian medicine patch is as follows:

[0153] (1) Preparation of paste

[0154] Prepare the powders of the Chinese medicinal materials according to the following weight proportions: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of stone cassia seed, and 0.5 parts of musk;

[0155] The powder particle size of each Chinese herbal medicine is 200 mesh;

[0156] The raw material powders are mixed evenly and divided into two materials of 1 / 10 and 9 / 10 weight. The 1 / 10 weight is recorded as material A, and the 9 / 10 weight is recorded as material B.

[0157] Material A was mixed with the extraction solvent, and allowed to stand for extraction for 1 h. The mixture was filtered through a 250-mesh filter, the Chinese medicinal residue was discarded, the filtrate was collected, concentrated into an extract, dried, and made into a 200-mesh powder for later use;

[0158] The solvent used is a mixture of 60% ethanol and disodium ethylenediaminetetraacetate by volume, wherein the volume ratio of 60% ethanol to disodium ethylenediaminetetraacetate is 100:0.5; the mass ratio of material A to the extraction solvent is 1:8;

[0159] The auxiliary material is a mixture of sesame oil and 60% ethanol by volume. The volume ratio of sesame oil to 60% ethanol is 1:100, and the two are firstly fully mixed to obtain an auxiliary material mixture;

[0160] The auxiliary material mixture is added into a uniform mixture of the above raw material powders, and the mixture is adjusted into a paste to obtain a paste ointment.

[0161] (2) Prepare the patch

[0162] The paste ointment is applied on the patch. After the paste is applied on the patch, the thickness is 1mm, and a Mongolian medicine patch applied on the skin wound is made.

[0163] The paste is in a viscous state. After the paste is applied on the patch with a thickness of 1 mm, the patch is picked up vertically, and the paste does not flow within 10 seconds.

[0164] For ease of reading, the differences in the preparation processes of Example 1 and Examples 4-7 are summarized in the following Table 2.

[0165] Table 2 Differences in preparation process of each embodiment

[0166]

[0167] Note: “-” means that the processing does not exist.

[0168] Effect verification 1: efficacy experiment

[0169] (1) Grouping

[0170] BABI / C mice were used and divided into a model control group and several drug-treated groups, with 6 mice in each group.

[0171] (2) Processing

[0172] All mouse wounds were produced by intraperitoneal injection of 0.25% Avertin to anesthetize the mice, and a 5 cm × 5 cm area of ​​the mouse back skin was depilated. The depilated area was disinfected with alcohol, and symmetrical, equal-sized, 5 mm diameter full-thickness skin excision wounds were made on both sides of the posterior lumbar position 1 cm away from the spine with the spine as the central axis.

[0173] (3) Administration

[0174] Different medication groups were given patches of different embodiments, with specifications of 2 cm side length, square plaster layer, 1 cm side length, the plaster layer was smeared in the center of the patch, and the thickness was 1 mm.

[0175] The mice in the drug administration group were given a dose of Mongolian medicine patch at a fixed time and quantity every day, and the patch was fixed with tape for 2 hours each time. The wounds of the mice in the model control group were disinfected with iodine once a day. The initial treatment time of all groups was the same.

[0176] Each mouse was housed in a single cage and fed freely. The mice were photographed and observed for 9 consecutive days, and the wound area was statistically analyzed.

[0177] (4) Result statistics

[0178] The wound healing rate of mice in each group was calculated.

[0179] Wound healing rate = 100% × wound area at measurement / original wound area

[0180] The average wound healing rates of 6 mice in each group were taken and recorded in Table 3.

[0181] Table 3 Statistics of wound healing rate

[0182]

[0183] The results show that each example has a good wound healing effect. We also used the Mongolian medicine patch prepared in Example 1 to conduct a test experiment on real volunteers. The therapeutic effect is shown in Figure 1 , the carbuncle healed well.

[0184] Effect verification 2: Dextrorotatory borneol extraction rate test

[0185] Material A and the extraction solvent were mixed in a mass ratio of 1:6, allowed to stand for extraction, filtered through a 250-mesh filter, the Chinese medicinal residue was discarded, the filtrate was collected, concentrated into an extract, dried, and the content of dextrorotatory borneol in the dried product was tested.

[0186] Wherein material A is material A of Example 5.

[0187] Table 4 records the extraction solvent differences and the test results of borneol content.

[0188] Table 4 Differences in extraction conditions and test results of d-borneol content

[0189]

[0190] It should be noted that when the present invention involves a numerical range, it should be understood that the two endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods used are the same as those in the embodiments, in order to avoid redundancy, the present invention describes a preferred embodiment. Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they know the basic creative concept. Therefore, the attached claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0191] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A Mongolian medicine patch for treating skin wounds, characterized in that: Includes creams and patches; The ointment is prepared from the following raw materials in parts by weight: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk; auxiliary materials are added to make a paste; The patch is a soft cloth; The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

2. The Mongolian medicine patch for treating skin wounds according to claim 1, wherein: The auxiliary material is a mixture of sesame oil and 60% by volume ethanol.

3. The Mongolian medicine patch for treating skin wounds according to claim 2, wherein: The ointment is prepared from the following raw materials in parts by weight: 35 parts of calcite, 25 parts of borneol, 10 parts of realgar, 5 parts of cinnabar, 5 parts of vermilion, 5 parts of cassia bark, and 0.5 parts of musk.

4. The preparation method of the Mongolian medicine patch for treating skin wounds according to claim 1, wherein include: (1) Preparation of paste Prepare the powder of each Chinese medicinal material according to the following weight proportions: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk; Mix the above raw material powders evenly, and add auxiliary materials to make a paste; (2) Prepare the patch The paste is spread on the patch to prepare a Mongolian medicine patch for application on the skin wound.

5. The preparation method of the Mongolian medicine patch for treating skin wounds according to claim 1, wherein include: (1) Preparation of paste Prepare the powder of each Chinese medicinal material according to the following weight proportions: 35-40 parts of calcite, 25-30 parts of borneol, 10-15 parts of realgar, 5-10 parts of cinnabar, 5-8 parts of silver vermilion, 5-8 parts of stone cassia seed, and 0.5-1 part of musk; The raw material powders are mixed evenly and divided into two materials of 1 / 10 and 9 / 10 weight. The 1 / 10 weight is recorded as material A, and the 9 / 10 weight is recorded as material B. Material A is mixed with the extraction solvent, and the mixture is allowed to stand for extraction for 1-2 hours, filtered, the Chinese medicine residue is discarded, the filtrate is collected, concentrated into an extract, and dried for later use; After material B is fully mixed with the dried extract, auxiliary materials are added to form a paste to obtain a paste ointment; (2) The paste is applied on the patch to make a Mongolian medicine patch for application on the skin wound.

6. The preparation method of the Mongolian medicine patch for treating skin wounds according to claim 4 or 5, wherein: The powder particle size of each Chinese medicinal material is 150-200 meshes.

7. The preparation method of the Mongolian medicine patch for treating skin wounds according to claim 6, wherein: After the paste is applied to the patch, the thickness of the paste is 1-2 mm.

8. The preparation method of the Mongolian medicine patch for treating skin wounds according to claim 5, wherein: When material A is mixed with the extraction solvent, the solvent used is a mixed solution of 60% by volume ethanol and disodium ethylenediaminetetraacetate, wherein the volume ratio of 60% by volume ethanol to disodium ethylenediaminetetraacetate is 100:0.5-1.

9. The method for preparing the Mongolian medicine patch for treating skin wounds according to claim 8, wherein: The mass ratio of material A to extraction solvent is 1:6-8.

10. The method for preparing the Mongolian medicine patch for treating skin wounds according to claim 9, wherein: The main active ingredient in the extract is d-borneol.

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