Microneedle subcutaneous rotary drive hollow ultrasonic motor

Abstract

The application provides a hollow ultrasonic motor for subcutaneous rotation driving of microneedles, which comprises a microneedle, an ultrasonic motor rotor assembly, an ultrasonic motor stator assembly and a base, the ultrasonic motor rotor assembly comprises a microneedle driving table, a microneedle pressing stud and a hollow ultrasonic motor rotor, the microneedle passes through the ultrasonic motor rotor, the microneedle driving table and the microneedle pressing stud clamp the microneedle together; the ultrasonic motor stator assembly is fastened and installed on the base, the hollow sidewall of the ultrasonic motor rotor assembly is inserted into the base and a bearing is arranged between the base and the sidewall, the ultrasonic motor stator assembly is in transmission connection with the ultrasonic motor rotor assembly, the ultrasonic motor rotor assembly can rotate around a central shaft, and the microneedle rotates synchronously with the ultrasonic motor rotor assembly. The microneedle is clamped by the ultrasonic motor rotor assembly, the ultrasonic motor rotor assembly is driven to rotate by the ultrasonic motor stator, the motor can directly drive the microneedle, an intermediate transmission mechanism is not needed, and further integration with a rear end executor is facilitated.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of microneedle transdermal precise drug delivery, in particular, to a microneedle subcutaneous rotation driving hollow ultrasonic motor. BACKGROUND

[0002] Drug therapy is considered to be one of the most effective methods for treating a series of diseases such as diabetes and Crohn's disease, and the current commonly used drug delivery methods in medicine mainly include oral administration, injection and transdermal administration. The oral administration method has the advantages of convenience, non-invasiveness and high compliance, however, due to the poor absorption of the gastrointestinal tract and the degradation effect of various digestive enzymes (first-pass effect), drugs such as antibodies and peptides cannot be delivered by this method, and the required dose and pharmacokinetic effect need to be delivered by intravenous injection. Intravenous injection is a drug delivery method with rapid onset and few side effects, which can deliver almost any type of molecule into the body, but this method requires the user to have professional skills, master the correct injection method and safe needle handling method. In addition, intravenous injection also has the problems of fear of needle pain and needle phobia in some patients, which seriously limits the promotion of injection drug delivery.

[0003] Transdermal drug delivery refers to the diffusion of drugs through the epidermis, which is absorbed by capillaries in the dermis and then enters the blood circulation to achieve drug delivery, which has the advantages of convenient drug delivery, stable blood drug concentration and no first-pass effect, but the drug penetration rate of this method is usually low. Studies have shown that only a small number of potent drug molecules with high lipophilicity and small molecular weight can be directly administered by passive diffusion. Currently, physical and chemical means such as iontophoresis, microneedle transdermal and nanocarriers are mainly used to improve the transdermal penetration rate of drugs, among which the iontophoresis method relies on expensive equipment and is relatively complex to operate. Some nanomaterials show toxic characteristics, and drug delivery through nanocarriers may cause adverse skin reactions and significant pain. In recent years, transdermal microneedle drug delivery technology has gradually become a research hotspot due to its painless, minimally invasive, good compliance and high drug utilization, and is one of the most promising drug delivery methods.

[0004] The existing patent with publication number CN106178245A discloses a microneedle array device for minimally invasive and precise subcutaneous administration. The device comprises an injection pump, a hose and five needle heads. The injection pump comprises a lead screw, a clamp, a syringe, a base, a lead screw, a nut pusher, a screw rod and a stepping motor. One end of the lead screw and the screw rod is connected with the stepping motor, the other end of the lead screw passes through the nut pusher and is fixed on the base through a support, the other end of the screw rod is directly fixed on the nut pusher, the syringe is fixed in the V-shaped guide groove of the base through the clamp, and the piston of the syringe is connected with the nut pusher. The stepping motor drives the screw rod to rotate, the rotation of the screw rod drives the nut to move linearly, the nut pushes the nut pusher to move along the guide direction of the lead screw, thereby pushing the syringe piston to move to the right, and the liquid medicine in the syringe enters the five needle heads through the hose.

[0005] The microneedle transdermal drug delivery method is to use micrometer-level needle-shaped bodies made of metal, glass or polymer to penetrate the epidermis to form a micro channel, and to promote the transdermal penetration of drugs through the channel, so that the drugs are directly absorbed in the body circulation. In order to realize precise administration of specific skin layers and reduce the risk of subcutaneous fracture of microneedles, it is necessary to reduce the penetration resistance, skin deformation and deformation recovery time in a rotating-piercing manner. The existing microneedle drug delivery system usually uses an electromagnetic motor to realize two-degree-of-freedom rotation-piercing motion, which needs to be equipped with a complex intermediate transmission mechanism, increasing the motion error of the front-end microneedle and the overall volume of the system, and it is difficult to realize the precise positioning of the microneedle under the skin and the miniaturization of the system.

[0006] Therefore, a microneedle rotating drive device with high motion accuracy, large torque and integrated structure is proposed, that is, a hollow ultrasonic motor with high motion accuracy, large torque and compact structure is provided, which is used to realize precise rotating motion of microneedles under the skin, and has great significance for the mechanism research and clinical application of microneedle transdermal drug delivery. SUMMARY

[0007] In view of the defects in the prior art, the purpose of the present application is to provide a hollow ultrasonic motor for driving microneedle rotation under the skin.

[0008] According to the hollow ultrasonic motor for driving microneedle rotation under the skin provided by the present application, the microneedle, the ultrasonic motor rotor assembly, the ultrasonic motor stator assembly and the base are provided, the ultrasonic motor rotor assembly comprises a microneedle driving table, a microneedle pressing stud and a hollow ultrasonic motor rotor, the microneedle passes through the ultrasonic motor rotor, and the microneedle driving table and the microneedle pressing stud clamp the microneedle in cooperation;

[0009] The ultrasonic motor stator assembly is fastened and installed on the base, the hollow side wall of the ultrasonic motor rotor assembly is inserted into the base and a bearing is arranged therebetween, the ultrasonic motor stator assembly is in transmission connection with the ultrasonic motor rotor assembly, the ultrasonic motor rotor assembly can rotate around the central axis thereof, and the microneedle rotates synchronously with the ultrasonic motor rotor assembly.

[0010] Preferably, the central axes of the ultrasonic motor rotor assembly, the ultrasonic motor stator assembly, the base and the bearing are coaxially arranged, and the microneedle is coaxially arranged with the central axis of the ultrasonic motor rotor.

[0011] Preferably, the ultrasonic motor stator assembly comprises an ultrasonic motor stator, the ultrasonic motor rotor bottom surface of the ultrasonic motor rotor is adhered with a friction material, and the ultrasonic motor rotor bottom surface is pressed on the ultrasonic motor stator tooth end top surface of the ultrasonic motor stator through the friction material.

[0012] Preferably, the ultrasonic motor stator tooth end bottom surface of the ultrasonic motor stator is attached with a piezoelectric ceramic sheet, the piezoelectric ceramic sheet comprises A and B two-phase polarization partitions, the A and B two-phase polarization partitions are respectively connected with two-phase voltages having a phase difference of π / 2 in time, each particle on the ultrasonic motor stator tooth end top surface performs elliptical motion, and the ultrasonic motor rotor assembly is driven to rotate through friction.

[0013] Preferably, the microneedle driving table is arranged above the ultrasonic motor rotor, the top of the hollow side wall of the ultrasonic motor rotor extends inward to form a mounting portion, the lower surface of the microneedle driving table extends downward to form a lower protrusion corresponding to the mounting portion, one or more threaded mounting holes are formed in the mounting portion, a mounting hole is formed in the lower protrusion in correspondence, and the microneedle driving table and the ultrasonic motor rotor are fastened and connected through a bolt assembly passing through the threaded mounting hole and the mounting hole.

[0014] Preferably, the microneedle driving table comprises a V-shaped block and a pressing stud support, the microneedle is arranged in the V-shaped surface of the V-shaped block, a threaded hole is formed in the pressing stud support, the center axis of the threaded hole is coaxially arranged with the V-shaped center of the V-shaped block, a microneedle pressing stud is installed in the threaded hole and threadedly cooperates with the threaded hole, and the microneedle pressing stud can move towards or away from the V-shaped block along the center axis direction of the threaded hole.

[0015] Preferably, the microneedle driving table is made by 3D printing.

[0016] Preferably, the microneedle comprises a microneedle with a diameter of 300 μm-1 mm and a length of 4 mm-50 mm.

[0017] Preferably, the base is stepped, comprising three layers from inside to outside, the ultrasonic motor stator assembly is installed on the outside of the upper layer of the base, the outside of the sidewall of the upper layer of the base is provided with a threaded three, the ultrasonic motor stator assembly comprises a threaded three and a threaded four stacked upside down, and the support end of the ultrasonic motor stator assembly is pressed on the base support surface of the middle layer of the base through the threaded cooperation of the threaded four, the threaded three and the threaded three.

[0018] Preferably, the ultrasonic motor rotor assembly comprises a threaded one and a threaded two stacked upside down, the bottom of the hollow sidewall of the ultrasonic motor rotor is provided with a threaded two, the bearing is arranged on the outside of the hollow sidewall of the ultrasonic motor rotor and above the threaded two, and the inside of the middle layer of the base is provided with a base positioning surface, the bearing is pressed on the base positioning surface through the threaded cooperation of the threaded one, the threaded two and the threaded two.

[0019] Compared with the prior art, the application has the following beneficial effects:

[0020] 1、The V-shaped block on the microneedle driving table and the microneedle pressing stud clamp the microneedle, the ultrasonic motor stator frictionally drives the ultrasonic motor rotor assembly to rotate, and then the rotation movement of the microneedle under the skin is accurately and reliably realized, the motor can directly drive the microneedle, without the need to design an intermediate transmission mechanism, thereby avoiding the problems of low movement accuracy and large device size caused by the intermediate transmission mechanism in the traditional driving device, facilitating further integration with the rear-end executor, having the characteristics of fast response speed and power-off self-locking, and the microneedle can well follow the movement characteristics when moving under the skin, and can always complete the corresponding movement in time according to the instruction, and can maintain the current state by means of a large holding torque when there is no input signal, and perform the next stage of drug delivery task.

[0021] 2、The application applies two-phase voltage with a phase difference of π / 2 in time on the A and B two-phase polarization areas of the piezoelectric ceramic sheet, excites A and B two-phase vibration modes on the ultrasonic motor stator, and superimposes a traveling wave, so that each particle on the top surface of the tooth end of the ultrasonic motor stator makes an elliptical movement, has the characteristics of low speed and large torque, and can provide sufficient rotation driving torque in the process of the microneedle penetrating the skin, and reduce the movement interference caused by skin tissue friction.

[0022] 3、The V-shaped block with different geometric parameters can be prepared by 3D printing, the rotation driving of microneedles with different diameters and lengths can be realized, and flexible expansion can be realized according to different research requirements and application scenarios. BRIEF DESCRIPTION OF DRAWINGS

[0023] Other features, objects and advantages of the application will become more apparent from the following detailed description of non-limiting embodiments, made with reference to the accompanying drawings:

[0024] Figure 1 The overall structure of the hollow ultrasonic motor driven by the microneedle is shown in the sectional view;

[0025] Figure 2 The structure of the ultrasonic motor rotor assembly is shown in the schematic view;

[0026] Figure 3 The microneedle pressing schematic view is shown in the schematic view;

[0027] Figure 4 The structure of the ultrasonic motor stator assembly is shown in the schematic view;

[0028] Figure 5 The hollow ultrasonic motor driven by the microneedle is shown in the exploded schematic view;

[0029] Figure 6 The piezoelectric ceramic polarization partition schematic view is shown in the schematic view;

[0030] Figure 7 The A and B phase modal vibration mode simulation view is shown in the schematic view.

[0031] The schematic view shown in the figure:

[0032] Microneedle 1 Ultrasonic motor rotor assembly 2

[0033] Ultrasonic motor rotor 21 Ultrasonic motor rotor bottom surface 211

[0034] Friction material 22 Microneedle driving table 23

[0035] V-shaped block 231 V-shaped surface 2311

[0036] Pressing screw column support 232 Microneedle pressing screw column 24

[0037] Pressing screw column bottom surface 241 Threaded mounting hole 25

[0038] Thread two 26 Nut one 27

[0039] Nut one upper surface 271 Nut two 28

[0040] Ultrasonic motor stator assembly 3 Ultrasonic motor stator 31

[0041] Ultrasonic motor stator tooth end top surface 311 Ultrasonic motor stator tooth end bottom surface 312

[0042] Ultrasonic motor stator support end bottom surface 313 Ultrasonic motor stator support end top surface 314

[0043] Nut three 32 Nut four 33

[0044] Nut three bottom surface 321 Piezoelectric ceramic sheet 34

[0045] Base 4 Threaded Three 41

[0046] Base Support Surface 42 Base Positioning Surface 43

[0047] Bearing 5 Bearing Outer Ring Upper Surface 51

[0048] Bearing Inner Ring Lower Surface 52 DETAILED DESCRIPTION

[0049] The application will be described in detail below with specific embodiments. The following examples will help those skilled in the art to further understand the application, but do not limit the application in any form. It should be noted that for those skilled in the art, without departing from the concept of the application, a number of changes and improvements can be made. These are within the scope of the application.

[0050] As Figures 1-5 shown, according to the hollow ultrasonic motor provided by the application, a microneedle subcutaneous rotation drive hollow ultrasonic motor comprises a microneedle 1, an ultrasonic motor rotor assembly 2, an ultrasonic motor stator assembly 3 and a base 4. The ultrasonic motor rotor assembly 2 comprises a microneedle driving platform 23, a microneedle pressing stud 24 and a hollow ultrasonic motor rotor 21. The microneedle 1 passes through the ultrasonic motor rotor 21. The microneedle driving platform 23 and the microneedle pressing stud 24 cooperate to clamp the microneedle 1. The ultrasonic motor stator assembly 3 is tightly installed on the base 4. The hollow side wall of the ultrasonic motor rotor assembly 2 is inserted into the base 4 and a bearing 5 is arranged between the two. The ultrasonic motor stator assembly 3 is in transmission connection with the ultrasonic motor rotor assembly 2. The ultrasonic motor rotor assembly 2 can rotate around its central axis. The microneedle 1 rotates synchronously with the ultrasonic motor rotor assembly 2.

[0051] The application can realize the subcutaneous precise rotation movement of the microneedle 1, reduce the subcutaneous positioning error and the risk of fracture of the microneedle 1, and has the advantages of compact structure and easy integration.

[0052] The central axes of the ultrasonic motor rotor assembly 2, the ultrasonic motor stator assembly 3, the base 4 and the bearing 5 are coaxially arranged. The central axis of the microneedle 1 is coaxially arranged with the central axis of the ultrasonic motor rotor 21.

[0053] The ultrasonic motor stator assembly 3 comprises an ultrasonic motor stator 31. The ultrasonic motor rotor bottom surface 211 of the ultrasonic motor rotor 21 is adhered with a friction material 22. The ultrasonic motor rotor bottom surface 211 is pressed on the ultrasonic motor stator tooth end top surface 311 of the ultrasonic motor stator 31 through the friction material 22.

[0054] As Figure 6 and 7As shown, the ultrasonic motor stator tooth end bottom surface 312 of the ultrasonic motor stator 31 is attached with a piezoelectric ceramic sheet 34, the piezoelectric ceramic sheet 34 includes A and B two-phase polarization partitions, A and B two-phase polarization partitions are respectively connected with two-phase voltage with a phase difference of π / 2 in time, and A and B two-phase vibration modes are excited on the ultrasonic motor stator 31, and a traveling wave is superimposed, each particle on the ultrasonic motor stator tooth end top surface 311 performs elliptical motion, and the ultrasonic motor rotor assembly 2 is driven to rotate through friction, and then drives the microneedle 1 to rotate.

[0055] The microneedle driving table 23 is arranged above the ultrasonic motor rotor 21, the top of the hollow side wall of the ultrasonic motor rotor 21 extends inward to form a mounting portion, the lower surface of the microneedle driving table 23 extends downward to form a lower protrusion corresponding to the mounting portion, one or more threaded mounting holes 25 are formed on the mounting portion, and a mounting hole is formed on the lower protrusion corresponding to the mounting portion. The microneedle driving table 23 and the ultrasonic motor rotor 21 are fastened and connected through a bolt assembly passing through the threaded mounting hole 25 and the mounting hole.

[0056] The microneedle driving table 23 includes a V-shaped block 231 and a pressing stud support 232, the microneedle 1 is arranged in the V-shaped surface 2311 of the V-shaped block 231, a threaded hole is formed on the pressing stud support 232, the center axis of the threaded hole is coaxially arranged with the V-shaped center of the V-shaped block 231, the microneedle pressing stud 24 is installed in the threaded hole and threadedly matched with the threaded hole, and the microneedle pressing stud 24 can move close to or away from the V-shaped block 231 along the center axis direction of the threaded hole. The microneedle pressing stud 24 is screwed into the pressing stud support 232, and the V-shaped surface 2311 of the V-shaped block 231 and the bottom surface 241 of the microneedle pressing stud are used to press and fix the microneedle 1.

[0057] The microneedle driving table 23 is made by 3D printing. The microneedle 1 includes a microneedle with a diameter of 300μm-1mm and a length of 4mm-50mm, that is, by adjusting the geometric parameters of the V-shaped block 231, the microneedle 1 with a diameter of 300μm-1mm and a length of 4mm-50mm can be clamped.

[0058] The base 4 is ladder-shaped and includes three layers from inside to outside, the ultrasonic motor stator assembly 3 is installed on the outside of the upper layer of the base 4, the outer side of the sidewall of the upper layer of the base 4 is provided with a threaded three 41, the ultrasonic motor stator assembly 3 includes a nut four 33 and a nut three 32 stacked one above the other, and the nut three 32 and the nut four 33 are threadedly matched with the threaded three 41 to tightly press the nut three bottom surface 321 to the ultrasonic motor stator support end top surface 314, that is, the support end of the ultrasonic motor stator assembly 3 is tightly pressed on the base support surface 42 of the middle layer of the base 4 through the threaded cooperation of the nut four 33, the nut three 32 and the threaded three 41, thereby realizing the fixation between the ultrasonic motor stator assembly 3 and the base 4.

[0059] The ultrasonic motor rotor assembly 2 comprises a nut 1 27 and a nut 2 28 stacked one above the other, the bottom of the hollow side wall of the ultrasonic motor rotor 21 is provided with a thread 2 26, the bearing 5 is sleeved on the outside of the hollow side wall of the ultrasonic motor rotor 21 and located above the thread 2 26, the inner side of the middle layer step of the base 4 is provided with a base positioning surface 43, the nut 1 27 and the nut 2 28 are pressed against the inner ring lower surface 52 of the bearing through the thread 2 26, and the outer ring upper surface 51 of the bearing is pressed against the base positioning surface 43, that is, the bearing 5 is pressed and tightened on the base positioning surface 43 through the thread cooperation of the nut 1 27, the nut 2 28 and the thread 2 26, the friction material 22 is tightly pressed against the ultrasonic motor stator tooth end top surface 311, and the pre-tightening between the ultrasonic motor rotor assembly 2 and the ultrasonic motor stator assembly 3 is realized.

[0060] The working principle of the application is as follows: the micro-needle 1 is clamped by the V-shaped block 231 on the micro-needle driving table 23 and the micro-needle pressing stud 24, two-phase voltages with a phase difference of π / 2 are applied to the A and B polarized regions of the piezoelectric ceramic sheet 34, A and B two-phase vibration modes are excited on the ultrasonic motor stator 31, and a traveling wave is superimposed, so that each particle on the ultrasonic motor stator tooth end top surface 311 performs elliptical motion, and the ultrasonic motor rotor assembly 2 is driven to rotate by friction, and then the rotation of the micro-needle 1 under the skin is accurately and reliably realized. The V-shaped block 231 with different geometric parameters prepared by 3D printing can realize the rotation driving of micro-needles 1 with different diameters and lengths, and flexible expansion can be realized according to different research needs and application scenarios.

[0061] The hollow ultrasonic motor for subcutaneous rotation driving of the micro-needle can directly drive the micro-needle 1 without designing an intermediate transmission mechanism, thereby avoiding the problems of low motion accuracy and large device volume caused by the intermediate transmission mechanism in the traditional driving device, and facilitating further integration with the rear-end executor.

[0062] The application has the characteristics of low speed and large torque, and can provide sufficient rotation driving torque in the process of the micro-needle 1 penetrating the skin, thereby reducing the motion interference caused by skin tissue friction.

[0063] The application has the characteristics of fast response speed and power-off self-locking, and the micro-needle 1 can have good follow-up characteristics when moving under the skin and can always complete the corresponding motion in time according to the instructions. When there is no input signal, a large holding torque can be used to maintain the current state and perform the next stage of drug delivery task.

[0064] The micro-needle driving table 23 is processed by 3D printing, and the geometric parameters of the V-shaped block 231 can be adjusted to drive micro-needles 1 with different diameters and lengths, and flexible expansion can be realized according to different research needs and application scenarios.

[0065] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like refer to the orientation or positional relationship shown in the drawings, and are only intended to facilitate the description of the present application and simplify the description, and are not intended to indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0066] The specific embodiments of the present application are described above. It should be understood that the present application is not limited to the above specific embodiments, and various changes or modifications can be made by those skilled in the art within the scope of the claims, which do not affect the essential content of the present application. The embodiments of the present application and the features in the embodiments can be arbitrarily combined with each other without conflict, provided that the combinations do not conflict.

Claims

1. A hollow ultrasonic motor for subcutaneous rotary driving of microneedles, characterized by, The application relates to a micro-needle driving device, which comprises a micro-needle (1), an ultrasonic motor rotor assembly (2), an ultrasonic motor stator assembly (3) and a base (4), the ultrasonic motor rotor assembly (2) comprises a micro-needle driving platform (23), a micro-needle pressing stud (24) and a hollow ultrasonic motor rotor (21), the micro-needle (1) penetrates through the ultrasonic motor rotor (21), the micro-needle (1) is clamped by the micro-needle driving platform (23) and the micro-needle pressing stud (24) in cooperation. The ultrasonic motor stator assembly (3) is fastened and installed on the base (4), the hollow side wall of the ultrasonic motor rotor assembly (2) is inserted into the base (4) and a bearing (5) is arranged between the base (4) and the ultrasonic motor rotor assembly (2), the ultrasonic motor stator assembly (3) is in transmission connection with the ultrasonic motor rotor assembly (2), the ultrasonic motor rotor assembly (2) can rotate around a central shaft, and the micro-needle (1) rotates synchronously with the ultrasonic motor rotor assembly (2). The ultrasonic motor stator assembly (3) comprises an ultrasonic motor stator (31), a friction material (22) is adhered to an ultrasonic motor rotor bottom surface (211) of the ultrasonic motor rotor (21), and the ultrasonic motor rotor bottom surface (211) is pressed on an ultrasonic motor stator tooth end top surface (311) of the ultrasonic motor stator (31) through the friction material (22). An ultrasonic motor stator tooth end bottom surface (312) of the ultrasonic motor stator (31) is attached with a piezoelectric ceramic sheet (34), the piezoelectric ceramic sheet (34) comprises two-phase polarization partitions A and B, the two-phase polarization partitions A and B are respectively connected with two-phase voltages with a phase difference of pi / 2 in time, each particle on the ultrasonic motor stator tooth end top surface (311) performs elliptical motion, and the ultrasonic motor rotor assembly (2) is driven to rotate through friction. The micro-needle driving platform (23) is arranged above the ultrasonic motor rotor (21), a top of the hollow side wall of the ultrasonic motor rotor (21) extends inward to form a mounting portion, a lower surface of the micro-needle driving platform (23) extends downward to form a lower protrusion corresponding to the mounting portion, one or more threaded mounting holes (25) are formed in the mounting portion, mounting holes are formed in the lower protrusion in correspondence, and the micro-needle driving platform (23) and the ultrasonic motor rotor (21) are fastened and connected through a bolt assembly penetrating through the threaded mounting holes (25) and the mounting holes. The central shafts of the ultrasonic motor rotor assembly (2), the ultrasonic motor stator assembly (3), the base (4) and the bearing (5) are coaxially arranged, and the micro-needle (1) is coaxially arranged with the central shaft of the ultrasonic motor rotor (21).

2. The microneedle subcutaneous rotary drive hollow ultrasonic motor of claim 1, wherein, ​ 3. The microneedle subcutaneous rotary drive hollow ultrasonic motor of claim 1, wherein, The micro-needle driving platform (23) comprises a V-shaped block (231) and a compression stud support (232), the micro-needle (1) is arranged in the V-shaped surface (2311) of the V-shaped block (231), the compression stud support (232) is provided with a threaded hole, the center axis of the threaded hole is coaxially arranged with the V-shaped center of the V-shaped block (231), the micro-needle compression stud (24) is installed in the threaded hole and is threadedly connected with the threaded hole, and the micro-needle compression stud (24) can be close to or away from the V-shaped block (231) along the center axis direction of the threaded hole.

4. The microneedle subdermal rotary drive hollow ultrasonic motor of claim 1, wherein, The micro-needle driving platform (23) is made by 3D printing.

5. The microneedle subdermal rotary drive hollow ultrasonic motor of claim 1, wherein, The micro-needle (1) comprises a micro-needle with a diameter of 300 μm-1 mm and a length of 4 mm-50 mm.

6. The microneedle subdermal rotary drive hollow ultrasonic motor of claim 1, wherein, The base (4) is in a stepped shape and comprises three layers from inside to outside, the ultrasonic motor stator assembly (3) is installed on the outside of the upper layer of the base (4), the outer side of the sidewall of the upper layer of the base (4) is provided with a threaded three (41), the ultrasonic motor stator assembly (3) comprises a threaded nut four (33) and a threaded nut three (32) stacked in layers, and the support end of the ultrasonic motor stator assembly (3) is threadedly connected and compressed on the base support surface (42) of the middle layer of the base (4) through the threaded nut four (33), the threaded nut three (32) and the threaded three (41).

7. The microneedle subdermal rotary drive hollow ultrasonic motor of claim 6, wherein, The ultrasonic motor rotor assembly (2) comprises a threaded nut one (27) and a threaded nut two (28) stacked in layers, the bottom of the hollow sidewall of the ultrasonic motor rotor (21) is provided with a threaded two (26), the bearing (5) is sleeved on the outside of the hollow sidewall of the ultrasonic motor rotor (21) and located above the threaded two (26), the inner side of the middle layer step of the base (4) is provided with a base positioning surface (43), and the bearing (5) is threadedly connected and compressed on the base positioning surface (43) through the threaded nut one (27), the threaded nut two (28) and the threaded two (26).

Images