Granulation equipment for producing small molecule peptide

Abstract

The invention discloses granulation equipment for small molecule peptide production. The granulation equipment comprises a bottom frame, a granulation chamber erected on the bottom frame and a stirring chamber penetrating through the top of the granulation chamber and fixed to the top of the granulation chamber. Wherein the bottom of the granulation chamber erected on the bottom frame is communicated with the discharging pipe, the side face of the top of the granulation chamber is communicated with the blast pipe, and the stirring chamber is fixed to the top of the granulation chamber; the stirring chamber is arranged at the bottom of the granulation chamber and is communicated with the spraying head; a stirring device is fixedly arranged at the top of the stirring chamber; the stirring device penetrates through the top of the stirring chamber and is arranged in the stirring chamber; the top of the stirring chamber is communicated with a pressurizing air pipe; the side upper part of the stirring chamber is communicated with a feeding pipe. According to the invention, solid and liquid in small molecule peptide slurry are uniformly distributed in a small molecule peptide granulation process, so that the small molecule peptide is prevented from blocking a spray head due to high temperature in equipment; in the subsequent material collecting process, the powdery small-molecule peptide generated in the granulating process is recycled, so that the recycling rate of the small-molecule peptide is increased, and meanwhile, the small-molecule peptide dust floating in the surrounding working environment is reduced.

Description

Technical Field

[0001] The invention belongs to the field of small molecule peptide production equipment and relates to a granulation equipment, in particular to a granulation equipment used for small molecule peptide production. Background Art

[0002] In the existing small molecule peptide production technology, granulation equipment is one of the indispensable equipment in the small molecule peptide production process. Small molecule peptide granulation equipment includes spray drying granulator, rotary granulator, swing granulator, boiling granulator and extrusion granulator, among which the more commonly used equipment is spray drying granulator and boiling granulator. Both use hot air to quickly air-dry and shape the small molecule peptide slurry, and at the same time, with the help of the wind force in the equipment, the small molecule peptide slurry can form a granular solid with uniform texture after drying.

[0003] However, for the current granulation equipment, whether it is spray drying granulation or boiling granulation, the small molecule peptide slurry is pumped into the granulation bin in the equipment by a pump. During the slurry injection process, the slurry will be in a static state for a long time, so that the small molecule peptide slurry will be stratified, which will make the slurry entering the granulation bin in the early stage too viscous, and the slurry entering the granulation bin in the later stage too thin; and because the temperature in the granulation bin is relatively high, the slurry is too viscous in the early stage of slurry injection, which will cause the spray head to be blocked, and the slurry injected in the later stage is too thin and cannot be stably formed. Finally, the small molecule peptide will flow out of the granulation bin in powder form, which increases the difficulty of collecting the small molecule peptide; at the same time, because the collection of small molecule peptide particles will use exhaust equipment, the powdered small molecule peptide will be extracted by the exhaust equipment, which not only reduces the recovery rate of the small molecule peptide and causes waste of small molecule peptides, but also because the exhaust equipment extracts the small molecule peptide powder and discharges it into the surrounding working space, which will increase the dust concentration in the surrounding working environment, which is not conducive to the health of the staff.

[0004] In summary, the current small molecule peptide granulation equipment still has some technical loopholes, and it is necessary to continue to develop small molecule peptide granulation equipment. Summary of the invention

[0005] In order to solve the above deficiencies in the prior art, the present invention aims to provide a granulation equipment for the production of small molecule peptides, so as to achieve uniform solid-liquid distribution in the small molecule peptide slurry during the small molecule peptide granulation process, and avoid the small molecule peptide from clogging the spray head due to the high temperature in the equipment; in the subsequent aggregation process, the powdered small molecule peptides generated in the granulation process are recovered, the recovery rate of the small molecule peptides is improved, and the floating small molecule peptide dust in the surrounding working environment is reduced.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is as follows: A granulation device for the production of small molecule peptides comprises a base frame, a granulation chamber mounted on the base frame, and a stirring chamber passing through the top of the granulation chamber and fixed to the top of the granulation chamber; wherein the granulation chamber mounted on the base frame is connected to a discharge pipe at the bottom, and connected to a blast pipe at the top side; a stirring chamber is fixed to the top of the granulation chamber, and the lower part of the stirring chamber passes through the top of the granulation chamber and is placed above the inside of the granulation chamber; the stirring chamber is placed at the bottom of the granulation chamber and is connected to a spray head; a support plate is fixedly arranged on the top of the stirring chamber, and a plurality of groups of connecting rods are vertically fixedly arranged on the upper part of the side of the support plate, and a rotating motor is fixedly arranged on one end of the connecting rod away from the supporting plate; the rotating motor is inverted, and a stirring paddle is fixedly arranged on the power output end of the rotating motor; the stirring paddle passes through the top of the stirring chamber and is placed inside the stirring chamber; the top of the stirring chamber is connected to a pressurized air duct; the upper part of the side of the stirring chamber is connected to a feeding pipe.

[0007] As a limitation of the present invention, the stirring paddle includes a stirring rod and multiple groups of stirring blades arranged on the stirring rod, wherein a first stirring blade and a second stirring blade are fixed in sequence from top to bottom on the part of the stirring rod placed in the stirring chamber, and the first stirring blade and the second stirring blade are arranged perpendicular to each other.

[0008] As a further limitation of the present invention, a connector is fixedly provided at one end of the stirring rod away from the rotating motor, the connector is placed in a spray head connected to the stirring chamber, and a third stirring blade is fixedly provided on the connector.

[0009] As a further limitation of the present invention, a fixed baffle is fixedly provided at the connection between the spray head and the bottom of the mixing chamber, the connecting head passes through the fixed baffle, and a rotating baffle is provided above or below the connection between the connecting head and the fixed baffle, and the rotating baffle is fixedly provided on the connecting head.

[0010] As another limitation of the present invention, a first screen is arranged in the stirring chamber between the feed pipe and the first stirring blade; the first screen is an ultrafiltration material and is fixedly arranged on the inner wall of the stirring chamber.

[0011] As the third limitation of the present invention, the discharge pipe connected to the bottom of the granulation chamber is connected to the distribution pipe body at one end away from the bottom of the granulation chamber, and one end of the distribution pipe is connected to the air inlet of the exhaust fan. A second screen is arranged inside the distribution pipe, and the second screen is arranged between the connection point between the discharge pipe and the distribution pipe body and the connection end between the distribution pipe and the air inlet of the exhaust fan.

[0012] As a fourth limitation of the present invention, the air outlet of the exhaust fan is connected with a connecting pipe, which is respectively connected with the pressurized air duct and the blast duct; a third screen is provided at the connection point between the blast duct and the connecting pipe.

[0013] As a fifth limitation of the present invention, the filtering accuracy of the second sieve is greater than the filtering accuracy of the third sieve.

[0014] As the sixth limitation of the present invention, the blast pipe is placed outside the granulation chamber and a heating device is provided at the part close to the connection point between the blast pipe and the granulation chamber; the heating device comprises a heating box, the heating box is arranged on the outside of the blast pipe, and a heating coil is arranged between the inside of the heating box and the outside of the part of the blast pipe placed inside the heating box.

[0015] As another limitation of the present invention, a pressure regulating valve is also provided on the top of the stirring chamber.

[0016] Due to the adoption of the above technical solution, the present invention has the following beneficial effects compared with the prior art: (1) The present invention relates to a granulation device for the production of small molecule peptides. A stirring chamber is provided on the granulation chamber to keep the small molecule peptide slurry in a stirring state, so that the small molecule peptide slurry maintains a relatively uniform concentration before granulation, thereby preventing the small molecule peptide slurry from being stratified due to standing and affecting the granulation effect.

[0017] (2) The present invention relates to a granulation device for the production of small molecule peptides. By arranging multiple groups of stirring blades on a stirring paddle, and the first stirring blade and the second stirring blade are perpendicular to each other, the stirring resistance of the small molecule peptide slurry is reduced, the effect of the small molecule peptide slurry is improved, and the small molecule peptide slurry is prevented from adhering to the inner wall of the stirring chamber.

[0018] (3) The present invention relates to a granulation device for the production of small molecule peptides, wherein a first screen is arranged between a feed pipe and a first stirring blade in a stirring chamber, and the first screen is an ultrafiltration material, so that the small molecule peptide slurry is further purified in the stirring chamber.

[0019] (4) The present invention relates to a granulation device for the production of small molecule peptides. By respectively arranging a fixed baffle and a rotating baffle inside the spray head and a connecting head disposed inside the spray head, the small molecule peptide slurry can be controlled to intermittently enter the spray head, thereby avoiding continuous pressurization in the stirring chamber, causing the spray head to continuously spray the small molecule peptide slurry into the granulation chamber, making it impossible to quickly dry and shape the slurry, thereby affecting the granulation effect.

[0020] (5) The present invention relates to a granulation device for the production of small molecule peptides. By extending a stirring paddle into a spray head and fixing a third stirring blade on a connecting head, the small molecule peptides can be prevented from adhering to the inner wall of the spray head due to the high temperature in the granulation chamber, thereby preventing the small molecule peptides from clogging the spray head due to long-term use.

[0021] (6) The present invention relates to a granulation device for the production of small molecule peptides. By arranging a connecting distribution pipe on the discharge pipe and adding a second screen in the distribution pipe, it is possible to prevent the small molecule peptides from being sucked into the exhaust fan and causing the exhaust fan to jam during the discharge process of the small molecule peptides through the exhaust fan.

[0022] (7) The present invention relates to a granulation device for the production of small molecule peptides. By setting up an exhaust fan, it can facilitate the rapid suction of small molecule peptide particles, and at the same time, it can also suppress the small molecule peptide dust generated in the granulation chamber when the small molecule peptide is granulated, and can also prevent the powdered small molecule peptide and the granular small molecule peptide from mixing and being difficult to separate.

[0023] (8) The present invention relates to a granulation device for the production of small molecule peptides. By arranging a connecting pipe and a blast pipe and a pressurized air duct connected to the connecting pipe at the air outlet of the exhaust fan, the wind force when the small molecule peptide particles are discharged can be utilized to pressurize the stirring chamber through the pressurized air duct and to blow air into the granulation chamber through the blast pipe.

[0024] (9) The present invention relates to a granulation device for the production of small molecule peptides. By adding a heating box and a heating coil on the outside of the blast pipe, the blast pipe can be heated so that the wind entering the granulation chamber is high-temperature hot air. The small molecule peptide slurry sprayed from the spray head is dried, shaped and granulated in the granulation chamber.

[0025] (10) The present invention relates to a granulation device for the production of small molecule peptides. By arranging a third screen at the connection point between the blast pipe and the connecting pipe, it is possible to prevent the powdered small molecule peptide absorbed by the exhaust fan during the process of discharging small molecule peptide particles from returning to the granulation chamber.

[0026] (11) The present invention relates to a granulation device for the production of small molecule peptides, which is connected to a connecting pipe through a pressurized air duct and a blast pipe at the same time, and a third screen is arranged in the blast pipe. Therefore, the small molecule peptide powder absorbed by the exhaust fan during the granulation process of the small molecule peptide particles enters the pressurized air duct connected to the stirring chamber through the connecting pipe. While the stirring chamber is pressurized, the small molecule peptide powder produced in the granulation chamber during the granulation process returns to the stirring chamber and is mixed with the small molecule peptide slurry again, thereby realizing the recovery and re-granulation of the small molecule peptide powder.

[0027] In summary, the present invention relates to a granulation device for the production of small molecule peptides, which can effectively achieve uniform solid-liquid distribution in the small molecule peptide slurry during the small molecule peptide granulation process, thereby avoiding the small molecule peptide from clogging the spray head due to the high temperature in the equipment; in the subsequent aggregation process, the powdered small molecule peptide generated in the granulation process is recovered, thereby improving the recovery rate of the small molecule peptide and reducing the small molecule peptide dust floating in the surrounding working environment.

[0028] The invention is suitable for the rapid drying and shaping of heat-sensitive small molecule liquid or semi-solid liquids such as small molecule peptides, and is used for the drying, shaping and granulation of heat-sensitive small molecule liquid or semi-solid liquids such as small molecule peptides. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] Figure 1 It is a structural schematic diagram of an embodiment of the present invention; Figure 2 A cross-sectional view of a granulation chamber according to an embodiment of the present invention; Figure 3 A cross-sectional view of a stirring chamber according to an embodiment of the present invention; Figure 4 It is an enlarged cross-sectional view of part A of an embodiment of the present invention; Figure 5 A cross-sectional view of a material distribution pipe according to an embodiment of the present invention; Figure 6 A cross-sectional view of a heating device according to an embodiment of the present invention; Figure 7 This is a physical diagram of the equipment used in the comparative example of the present invention.

[0031] In the figure: 1. base frame; 2. granulation chamber; 3. stirring chamber; 4. rotating motor; 5. connecting pipe; 6. material distribution pipe; 7. discharge pipe; 8. blast pipe; 9. spray head; 10. pressure regulating valve; 11. feed pipe; 12. pressurized air duct; 13. connecting rod; 14. support plate; 15. first screen; 16. first stirring blade; 17. second stirring blade; 18. stirring rod; 19. connecting head; 20. rotating baffle; 21. fixed baffle; 22. third stirring blade; 23. spray port; 24. second screen; 25. exhaust fan; 26. fan base; 27. heating box; 28. heating coil; 29. ​​third screen. DETAILED DESCRIPTION

[0032] The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and understand the present invention, and are not used to limit the present invention.

[0033] Example 1 A granulation device for the production of small molecule peptides like Figure 1 and Figure 2As shown in the figure, this embodiment relates to a granulating device for the production of small molecule peptides, including a chassis 1, a granulating chamber 2 erected on the chassis 1, and a stirring chamber 3 passing through the top of the granulating chamber 2 and fixed to the top of the granulating chamber 2; wherein, the bottom of the granulating chamber 2 erected on the chassis 1 is communicated with a discharge pipe 7, the side of the top is communicated with a blast pipe 8, the top of the granulating chamber 2 is fixed with a stirring chamber 3, and the lower part of the stirring chamber 3 passes through the top of the granulating chamber 2 and is placed above the inside of the granulating chamber 2; the stirring chamber 3 is placed at the bottom of the granulating chamber 2 and is communicated with a spraying head 9; a support plate 14 is fixedly arranged at the top of the stirring chamber 3, and at least three groups of connecting rods 13 arranged in a "pin" shape are vertically and fixedly arranged on the upper part of the side of the support plate 14. One end of the connecting rod 13 away from the support plate 14 is fixedly provided with a rotating motor 4; the rotating motor 4 is arranged upside down, and its power output end is fixedly provided with a stirring paddle; the stirring paddle passes through the top of the stirring chamber 3 and is placed inside the stirring chamber 3; the top of the stirring chamber 3 is communicated with a pressurized air pipe 12; the upper part of the side of the stirring chamber 3 is communicated with a feeding pipe 11; a pressure regulating valve 10 is also arranged at the top of the stirring chamber 3.

[0034] As Figure 3 and Figure 4 shown, the stirring paddle includes a stirring rod 18 and multiple groups of stirring blades arranged on the stirring rod 18. Among them, a first stirring blade 16 and a second stirring blade 17 are successively fixed on the part of the stirring rod 18 placed in the stirring chamber 3 from top to bottom, and the first stirring blade 16 and the second stirring blade 17 are arranged perpendicular to each other.

[0035] One end of the stirring paddle away from the rotating motor 4 is fixedly provided with a connecting head 19. The connecting head 19 is placed in the spraying head 9 communicated with the stirring chamber 3, and a third stirring blade 22 is fixedly arranged on the connecting head 19.

[0036] A fixed baffle 21 is fixedly arranged at the connection between the spraying head 19 and the bottom of the stirring chamber 3. The connecting head passes through the fixed baffle 21, and a rotating baffle 20 is arranged above the connection between the connecting head 19 and the fixed baffle 21. The rotating baffle 20 is fixedly arranged on the connecting head 19.

[0037] A first screen 15 is arranged between the feeding pipe 11 and the first stirring blade 16 inside the stirring chamber 3; the first screen 15 is made of ultrafiltration material and is fixedly arranged on the inner wall of the stirring chamber 3.

[0038] As Figure 5 shown, one end of the discharge pipe 7 communicated with the bottom of the granulating chamber 2 away from the bottom of the granulating chamber 2 is communicated with the pipe body of a distributing pipe 6. One end of the distributing pipe 6 is communicated with the air inlet of an air extractor 25. A second screen 24 is arranged inside the distributing pipe 6, and the second screen 24 is arranged between the connection between the discharge pipe 7 and the pipe body of the distributing pipe 6 and the connection end of the distributing pipe 6 and the air inlet of the air extractor 25.

[0039] As Figure 6As shown, the air outlet of the exhaust fan 25 is connected to a connecting pipe 5, which is respectively connected to the pressurized air duct 12 and the blast pipe 8; a third screen 29 with a filtering accuracy lower than that of the second screen 24 is provided at the connection point between the blast pipe 8 and the connecting pipe 5.

[0040] The blast pipe 8 is placed outside the granulation chamber 2 and a heating device is provided at the part close to the connection between the blast pipe 8 and the granulation chamber 2; the heating device includes a heating box 27, which is sleeved on the outside of the blast pipe 8, and a heating coil 28 is provided between the inner part 27 of the heating box and the outer side of the part of the blast pipe 8 placed inside the heating box 27.

[0041] When using this embodiment, the exhaust fan 25 is preferentially started to blow air to the stirring chamber 3 and the granulation chamber 2 through the pressurized air duct 12 and the blast pipe 8 respectively, and then the purified small molecule peptide slurry is injected into the stirring chamber 3 through the feeding pipe 11. After entering the stirring chamber 3, the small molecule peptide slurry first passes through the first screen 15 arranged below the feeding pipe 11 for secondary ultrafiltration, and the rotating motor 4 and the heating device are started at the same time. The stirring rod 18 is driven by the rotating motor 4, and the first stirring blade 16 and the second stirring blade 17 which are fixedly arranged perpendicularly to each other on the stirring rod 18 and are not in the same plane rotate with the stirring rod 18 to stir the small molecule peptide slurry entering the stirring chamber 3; and because a heating coil 28 and a heating box 27 are added to the outside of the blast pipe 8, the wind of the exhaust fan 25 passing through the blast pipe 8 is heated by the heating device and enters the granulation chamber 2 to dry and granulate the mist-like small molecule peptide slurry sprayed from the spray port 23 of the spray head 9 arranged at the lower part of the stirring chamber 3.

[0042] The dried small molecule peptide particles fall into the discharge pipe 7 arranged at the bottom of the granulation chamber 2 and enter the distribution pipe 6 connected to the discharge pipe 7 through the suction force of the exhaust fan 25. After entering the distribution pipe 6, the small molecule peptide particles fall from the open end of the distribution pipe 6 into the collection box prepared in advance due to their own gravity; The small molecule peptide powder produced by rapid drying and mutual collision between particles in the granulation chamber 2 enters the distribution pipe 6 along with the small molecule peptide particles. Since a second screen 24 is provided in the distribution pipe 6, the small molecule peptide particles are filtered out and fall out of the distribution pipe 6 due to their own gravity, while the small molecule peptide powder passes through the second screen 24, and moves to the pressurized air duct 12 and the blast pipe 8 respectively through the exhaust fan 25 and the connecting pipe 5 in turn. Because a third screen 29 with a filtration accuracy lower than that of the second screen 24 is provided at the connection between the blast pipe 8 and the connecting pipe 5, the small molecule peptide powder cannot enter the blast pipe 8, and can only enter the pressurized air duct 12 through the connecting pipe 5, and then re-enter the stirring chamber 3 through the pressurized air duct 12, mix with the remaining small molecule peptide slurry in the stirring chamber 3, and be sprayed into the granulation chamber 2 by the spray head 9 for re-granulation.

[0043] To improve the safety of the equipment, a pressure regulating valve 10 is also provided at the top of the mixing chamber 3 to balance the pressure inside the mixing chamber 3 and avoid potential safety hazards caused by excessive internal pressure in the mixing chamber 3.

[0044] Embodiment 2: A granulating device for small molecule peptide production As Figure 1 and Figure 2 shown, this embodiment relates to a granulating device for small molecule peptide production, including a chassis 1, a granulating chamber 2 erected on the chassis 1, and a mixing chamber 3 passing through the top of the granulating chamber 2 and fixed to the top of the granulating chamber 2; wherein, the bottom of the granulating chamber 2 erected on the chassis 1 is communicated with a discharge pipe 7, the side of the top is communicated with an air blowing pipe 8, the top of the granulating chamber 2 is fixed with a mixing chamber 3, and the lower part of the mixing chamber 3 passes through the top of the granulating chamber 2 and is placed above the inside of the granulating chamber 2; the mixing chamber 3 is placed at the bottom of the granulating chamber 2 and is communicated with a spraying head 9; a support plate 14 is fixedly arranged at the top of the mixing chamber 3, and at least three groups of connecting rods 13 arranged in a "pin" shape are vertically and fixedly arranged on the upper part of the side of the support plate 14. One end of the connecting rod 13 far from the support plate 14 is fixedly provided with a rotating motor 4; the rotating motor 4 is arranged upside down, and a stirring paddle is fixedly arranged at its power output end; the stirring paddle passes through the top of the mixing chamber 3 and is placed inside the mixing chamber 3; the top of the mixing chamber 3 is communicated with a pressurized air pipe 12; the upper part of the side of the mixing chamber 3 is communicated with a feed pipe 11; a pressure regulating valve 10 is also provided at the top of the mixing chamber 3.

[0045] As Figure 3 and Figure 4 shown, the stirring paddle includes a stirring rod 18 and multiple groups of stirring blades arranged on the stirring rod 18. Among them, a first stirring blade 16 and a second stirring blade 17 are sequentially fixed on the part of the stirring rod 18 placed in the mixing chamber 3 from top to bottom, and the first stirring blade 16 and the second stirring blade 17 are arranged perpendicular to each other.

[0046] One end of the stirring paddle far from the rotating motor 4 is fixedly provided with a connector 19. The connector 19 is placed inside the spraying head 9 communicated with the mixing chamber 3, and a third stirring blade 22 is fixedly arranged on the connector 19.

[0047] A fixed baffle 21 is fixedly arranged at the connection between the spraying head 19 and the bottom of the mixing chamber 3. The connector passes through the fixed baffle 21, and a rotating baffle 20 is arranged below the connection between the connector 19 and the fixed baffle 21. The rotating baffle 20 is fixedly arranged on the connector 19.

[0048] A first screen 15 is arranged between the feed pipe 11 and the first stirring blade 16 inside the mixing chamber 3; the first screen 15 is made of ultrafiltration material and is fixedly arranged on the inner wall of the mixing chamber 3.

[0049] As Figure 5As shown, the discharge pipe 7 connected to the bottom of the granulation chamber 2 is connected to the body of the distribution pipe 6 at one end away from the bottom of the granulation chamber 2, and one end of the distribution pipe 6 is connected to the air inlet of the exhaust fan 25. A second screen 24 is arranged inside the distribution pipe 6, and the second screen 24 is arranged between the connection point between the discharge pipe 7 and the body of the distribution pipe 6 and the connection end between the distribution pipe 6 and the air inlet of the exhaust fan 25.

[0050] like Figure 6 As shown, the air outlet of the exhaust fan 25 is connected to a connecting pipe 5, which is respectively connected to the pressurized air duct 12 and the blast pipe 8; a third screen 29 with a filtering accuracy lower than that of the second screen 24 is provided at the connection point between the blast pipe 8 and the connecting pipe 5.

[0051] The blast pipe 8 is placed outside the granulation chamber 2 and a heating device is provided at the part close to the connection between the blast pipe 8 and the granulation chamber 2; the heating device includes a heating box 27, which is sleeved on the outside of the blast pipe 8, and a heating coil 28 is provided between the inner part 27 of the heating box and the outer side of the part of the blast pipe 8 placed inside the heating box 27.

[0052] As a comparative example of the present invention, a small molecule oligopeptide spray dryer manufactured by Jiangsu Bohong Zhongjin Granulating Equipment Co., Ltd. is used. The equipment is a typical spray drying granulating equipment. The specific equipment is as follows Figure 7 shown.

[0053] As a comparative test, this comparative example uses two groups of small molecule peptides with a dry material weight of 1 kg and an appropriate amount of pure water to form a small molecule peptide slurry, and uses Example 1 of the present invention and the small molecule oligopeptide spray dryer manufactured by Jiangsu Bohong Zhongjin Granulation Equipment Co., Ltd. to granulate the small molecule peptides. After the granulation is completed, the granulation rate of the small molecule peptides of Example 1 of the present invention and the small molecule oligopeptide spray dryer manufactured by Jiangsu Bohong Zhongjin Granulation Equipment Co., Ltd., the recovery rate of the small molecule peptides, the granulation state of the small molecule peptide particles and the internal state data of the equipment after use are recorded and compared.

[0054] According to records, the granulation rate of small molecule peptide particles prepared by the small molecule oligopeptide spray dryer manufactured by Jiangsu Bohong Zhongjin Granulation Equipment Co., Ltd. in the comparative example was 95.32%; the small molecule peptide recovery rate was 93.02%; the granulation state of the small molecule peptide particles was relatively uniform, but in an irregular spherical shape, with a large amount of small molecule peptide powder attached to the surface; after the granulation was completed, a large amount of small molecule peptide powder was attached to the inner wall of the small molecule oligopeptide spray dryer manufactured by Jiangsu Bohong Zhongjin Granulation Equipment Co., Ltd.

[0055] The granulation rate of small molecule peptide particles prepared by the granulation equipment for small molecule peptide production involved in Example 1 of the present invention is 99.16%; the small molecule peptide recovery rate is 99.25%; the granulation state of the small molecule peptide particles is uniform, and they are regular spherical particles, with no small molecule peptide powder attached to the surface; after the granulation is completed, there is almost no small molecule peptide powder attached to the inner wall of the granulation equipment for small molecule peptide production involved in Example 1 of the present invention.

[0056] By comparison, the granulation equipment for small molecule peptide production involved in the present invention is superior to the existing small molecule peptide equipment in terms of both granulation rate and small molecule peptide recovery rate. Moreover, after the granulation is completed, there are only trace attachments inside the equipment, which reduces the maintenance frequency inside the equipment, reduces the equipment maintenance cost, and increases the service life of the equipment.

[0057] It should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions described in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A granulation device for the production of small molecule peptides, Features: The granulation equipment includes a base frame, a granulation chamber mounted on the base frame, and a stirring chamber that passes through the top of the granulation chamber and is fixed on the top of the granulation chamber; wherein, the bottom of the granulation chamber mounted on the base frame is connected to the discharge pipe, and the top side is connected to the blast pipe, a stirring chamber is fixed on the top of the granulation chamber, and the lower part of the stirring chamber passes through the top of the granulation chamber and is placed above the inside of the granulation chamber; the stirring chamber is placed on the bottom of the granulation chamber and is connected to a spray head; a support plate is fixed on the top of the stirring chamber, and a plurality of groups of connecting rods are vertically fixed to the upper side of the support plate, and a rotating motor is fixed on one end of the connecting rod away from the support plate; the rotating motor is inverted, and a stirring paddle is fixed on the power output end of the rotating motor; the stirring paddle passes through the top of the stirring chamber and is placed inside the stirring chamber; a pressurized air duct is connected to the top of the stirring chamber; a feeding pipe is connected to the upper side of the stirring chamber.

2. The granulation device for producing small molecule peptides according to claim 1, Features: The stirring paddle includes a stirring rod and a stirring blade arranged on the stirring rod, wherein a first stirring blade and a second stirring blade are fixed in sequence from top to bottom on the portion of the stirring rod placed in the stirring chamber, and the first stirring blade and the second stirring blade are arranged perpendicular to each other.

3. The granulation device for producing small molecule peptides according to claim 2, Features: A connector is fixedly provided at one end of the stirring rod away from the rotating motor. The connector is placed in the spray head connected to the stirring chamber. A third stirring blade is fixedly provided on the connector.

4. The granulation device for producing small molecule peptides according to claim 3, Features: A fixed baffle is fixedly arranged at the connection point between the spray head and the bottom of the stirring chamber, the connecting head passes through the fixed baffle, and a rotating baffle is arranged above or below the connection point between the connecting head and the fixed baffle, and the rotating baffle is fixedly arranged on the connecting head.

5. A granulation device for producing small molecule peptides according to any one of claims 1 to 4, Features: A first screen is arranged in the stirring chamber between the feed pipe and the first stirring blade; the first screen is an ultrafiltration material and is fixedly arranged on the inner wall of the stirring chamber.

6. The granulation device for producing small molecule peptides according to claim 1, Features: A discharge pipe is arranged at the bottom of the granulation chamber, and one end away from the bottom of the granulation chamber is connected to the distribution pipe body, and an exhaust fan is arranged at one end of the distribution pipe; a second screen is arranged inside the distribution pipe, and the second screen is arranged between the connection point between the discharge pipe and the distribution pipe body and the connection end between the distribution pipe and the air inlet of the exhaust fan.

7. The granulation device for producing small molecule peptides according to claim 6, Features: The exhaust fan air outlet is connected with a connecting pipe, and the connecting pipe is connected with the pressurized air pipe and the blast pipe respectively; a third screen is arranged at the connection point between the blast pipe and the connecting pipe.

8. The granulation device for producing small molecule peptides according to claim 7, Features: The filtering accuracy of the second screen is greater than the filtering accuracy of the third screen.

9. The granulation device for producing small molecule peptides according to claim 1, Features: The blast pipe is placed outside the granulation chamber and a heating device is provided at a portion close to the connection between the blast pipe and the granulation chamber; the heating device comprises a heating box, the heating box is sleeved on the outside of the blast pipe, and a heating coil is provided between the inside of the heating box and the outside of the portion of the blast pipe placed inside the heating box.

10. The granulation device for producing small molecule peptides according to claim 1, Features: A pressure regulating valve is also arranged on the top of the stirring chamber.

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