Sample injection valve

By designing a sample valve with flushing function, the through holes and slot layout of the stator and rotor can be used to switch the sample pump, which solves the equipment failure and detection abnormalities caused by air entering the chromatographic column, and improves the detection accuracy and operation convenience .

CN119103375AActive Publication Date: 2024-12-10INSCINSTECH CO LTD

Patent Information

Application Number
CN202411243855.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-05
Publication Date
2024-12-10
Estimated Expiration
2044-09-05

AI Technical Summary

Technical Problem

When using a high performance liquid chromatograph, air enters the chromatographic column and detector, causing equipment failure or abnormal detection results, and the disassembly and assembly of the sample pump is cumbersome and needs to be replaced frequently, resulting in a large amount of air mixed in the pipeline, affecting the detection accuracy.

Method used

A sample inlet valve with flushing function is designed. Through the specific through holes and slot layout of the stator and rotor, the rotor rotates relative to the stator, and the switching between flushing and different types of sample inlet pumps is realized, avoiding air entry and simplifying the inlet. Switching process of sample pump.

Benefits of technology

It effectively avoids air entering the chromatographic column, simplifies the switching process of the injection pump, improves detection accuracy and operation convenience, and reduces the risk of equipment damage.

✦ Generated by Eureka AI based on patent content.

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Abstract

The sample injection valve comprises a stator and a rotor, the stator is provided with a first through hole, a second through hole, a third through hole, a fourth through hole, a fifth through hole, a sixth through hole, a seventh through hole and an eighth through hole, a stator groove is formed in the inner surface of the stator, and a first rotor groove, a second rotor groove, a third rotor groove, a fourth rotor groove and a fifth rotor groove are formed in the inner surface of the rotor. The fifth rotor slot includes a first sub-slot and a second sub-slot in communication with the first sub-slot.
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Description

Technical Field

[0001] The present invention relates to the fields of protein purification, nucleic acid synthesis, liquid chromatography, and the like, and in particular to an injection valve having functions such as sample loading. Background Art

[0002] High performance liquid chromatography is an instrument that uses the differences in affinity such as distribution coefficients and adsorption capacity of various substances to be separated in two phases to separate them and then uses detectors such as ultraviolet light for detection.

[0003] When using a high performance liquid chromatograph, air may sometimes enter the chromatographic column and detector, causing the chromatographic column to fail or abnormal test results. In addition, when using a high performance liquid chromatograph, it is generally necessary to select different types of injection pumps according to the test requirements and the number of samples, so it is often necessary to disassemble and replace the injection pump and the connected pipelines, which is cumbersome to operate, and a large amount of air may be mixed in the disassembled pipelines, which may cause the chromatographic column to fail or abnormal test results. Summary of the invention

[0004] In order to overcome the above deficiencies in the prior art, the present invention proposes an injection valve with a flushing function and capable of switching between different types of injection pumps.

[0005] An object of the present invention is to provide an injection valve, comprising a stator (10) and a rotor (20), wherein the rotor is rotatable relative to the stator around a rotation axis, and wherein:

[0006] The stator comprises a stator inner surface and a stator outer surface, the stator is provided with a first through hole (1), a second through hole (2), a third through hole (3), a fourth through hole (4), a fifth through hole (5), a sixth through hole (6), a seventh through hole (7) and an eighth through hole (8) penetrating the stator inner surface and the stator outer surface, the stator inner surface is provided with a stator slot (5a), the first through hole, the second through hole, the third through hole, the fourth through hole, the fifth through hole and the eighth through hole are sequentially arranged on a circle with the rotation axis as the center and a first radius (R1), the sixth through hole and the seventh through hole are sequentially arranged on a circle with the rotation axis as the center and a second radius (R2), one end of the stator slot coincides with the fifth through hole and the other end (5b) of the stator slot extends to the circle with the second radius;

[0007] The rotor comprises an inner surface of the rotor which is closely and sealedly connected to the inner surface of the stator, and the inner surface of the rotor is provided with a first rotor slot (a), a second rotor slot (b), a third rotor slot (c), a fourth rotor slot (d) and a fifth rotor slot, wherein the fifth rotor slot comprises a first sub-slot (e-1) and a second sub-slot (e-2) which is connected to the first sub-slot, the first rotor slot (a), the second rotor slot (b) and the second sub-slot (e-2) are spaced apart from each other, and two ends of the first rotor slot (a), two ends of the second rotor slot (b) and two ends of the second sub-slot (e-2) are respectively located on a circle of the first radius (R1) and a circle of the second radius (R2), the third rotor slot (c), the fourth rotor slot (d) and the first sub-slot (e-1) are spaced apart from each other, and two ends of the third rotor slot (c), two ends of the fourth rotor slot (d) and two ends of the first sub-slot (e-1) are all located on the circle of the first radius (R1).

[0008] In some embodiments, when the rotor rotates to a first state, the first rotor slot connects the second through hole (2) and the sixth through hole (6), and the second rotor slot (b) connects the first through hole (1) and the stator slot (5a).

[0009] In some embodiments, when the rotor rotates to the second state, the first sub-slot (e-1) of the fifth rotor slot connects the first through hole (1) and the second through hole (2), the first rotor slot (a) connects the eighth through hole (8) and the seventh through hole (7), and the third rotor slot (c) connects the third through hole (3) and the fourth through hole (4).

[0010] In some embodiments, when the rotor rotates to the third state, the third rotor slot (c) connects the first through hole (1) and the second through hole (2), the second rotor slot connects the fifth through hole (5) and the seventh through hole (7), and the fourth rotor slot (d) connects the third through hole (3) and the fourth through hole (4).

[0011] In some embodiments, when the rotor rotates to the fourth state, the third rotor slot (c) connects the second through hole (2) and the third through hole (3), the fifth rotor slot connects the seventh through hole (7) and the first through hole (1), and the fourth rotor slot (d) connects the fifth through hole (5) and the fourth through hole (4).

[0012] In some embodiments, the first through hole is used to connect the chromatographic column, the second through hole is used to connect the system pump, the third through hole and the seventh through hole are used to connect the sample loop, the fourth through hole and the sixth through hole are respectively used to connect the waste liquid tank, and the eighth through hole and the fifth through hole are respectively used to connect the first injection pump and the second injection pump.

[0013] In some embodiments, the first rotor slot (a), the second rotor slot (b), and the second sub-slot (e-2) are all straight slots.

[0014] In some embodiments, the third rotor slot (c), the fourth rotor slot (d) and the first sub-slot (e-1) are all arc slots, and the arc slots are located on a circle with the first radius.

[0015] In some embodiments, the first radius is greater than the second radius.

[0016] In some embodiments, the injection valve further includes: a driving member connected to the rotor; and a controller connected to the driving member, wherein the controller is configured to control the driving member to drive the rotor to rotate around the rotation axis to the first state in response to a flushing instruction from a user.

[0017] The present invention arranges the through holes and slots of the stator and the rotor so that when the rotor rotates relative to the stator, the functions of flushing and switching different types of injection pumps can be realized, thereby meeting the detection requirements and detection accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The drawings described herein are used to provide a further understanding of the present disclosure and constitute a part of the present disclosure. The illustrative embodiments of the present disclosure and their descriptions are used to explain the present disclosure and do not constitute an improper limitation on the present disclosure. In the drawings:

[0019] Figure 1a A schematic diagram of the inner surface of a stator provided by some embodiments of the present invention is shown;

[0020] Figure 1b A schematic diagram of the outer surface of a stator provided by some embodiments of the present invention is shown;

[0021] Figure 1c A schematic diagram showing the layout of various through holes and stator slots in a stator provided in some embodiments of the present invention is shown;

[0022] Figure 2a A schematic diagram of a rotor provided by some embodiments of the present invention is shown;

[0023] Figure 2b A schematic diagram showing the layout of the grooves on the inner surface of the rotor provided by some embodiments of the present invention is shown;

[0024] Figure 3a A schematic diagram of a flow path of a sample valve in a first state provided by some embodiments of the present invention is shown;

[0025] Figure 3b A schematic diagram showing the coordination between the stator and the rotor of a sample valve provided by some embodiments of the present invention in a first state is shown;

[0026] Figure 4a A schematic diagram of a flow path of a sample valve in a second state provided by some embodiments of the present invention is shown;

[0027] Figure 4b A schematic diagram showing the coordination between the stator and the rotor of a sample valve provided by some embodiments of the present invention when the sample valve is in a second state is shown;

[0028] Figure 5a A schematic diagram of a flow path of a sample valve provided by some embodiments of the present invention in a third state is shown;

[0029] Figure 5b A schematic diagram showing the coordination between the stator and the rotor of a sample valve provided by some embodiments of the present invention in a third state is shown;

[0030] Figure 6a A schematic diagram of a flow path of a sample valve in a fourth state provided by some embodiments of the present invention is shown;

[0031] Figure 6b A schematic diagram showing the coordination between the stator and the rotor of a sample valve provided by some embodiments of the present invention when the sample valve is in a fourth state. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0033] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0034] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0035] Refer to the following Figures 1a to 6b The present invention will be described in detail.

[0036] The present invention provides an injection valve, comprising a stator 10 and a rotor 20, wherein the rotor 20 can rotate relative to the stator 10 around a rotation axis O, and the stator 10 has a stator inner surface ( Figure 1a The surface shown) and the stator outer surface ( Figure 1b The rotor 20 has a rotor inner surface ( Figure 2a The inner surface of the rotor and the inner surface of the stator are tightly and tightly connected.

[0037] The surface of the rotor 20 opposite to the inner surface of the stator is the inner surface of the rotor. The inner surface of the rotor and the inner surface of the stator are tightly sealed and connected to each other, and a certain extrusion force exists between the inner surface of the rotor and the inner surface of the stator.

[0038] For example, the stator 10 and the rotor 20 may be cylindrical or disc-shaped, respectively, and the sizes of the two may be similar. The rotation axis O of the rotor 20 may pass through the center (center of the circle) of the stator 10 and the rotor 20. Of course, the shapes of the stator 10 and the rotor 20 may also be other shapes, such as square, prism, etc.

[0039] like Figure 1a and Figure 1b As shown, the stator 10 is provided with a first through hole 1, a second through hole 2, a third through hole 3, a fourth through hole 4, a fifth through hole 5, a sixth through hole 6, a seventh through hole 7 and an eighth through hole 8 penetrating the inner surface and the outer surface of the stator, and a stator slot 5a is provided on the inner surface of the stator. Figure 1c As shown, the first through hole 1, the second through hole 2, the third through hole 3, the fourth through hole 4, the fifth through hole 5 and the eighth through hole 8 are arranged in sequence on a circle with the rotation axis O as the center and the first radius R1, the sixth through hole 6 and the seventh through hole 7 are arranged in sequence on a circle with the rotation axis O as the center and the second radius R2, one end of the stator slot 5a coincides with the opening end of the fifth through hole 5 on the inner surface of the stator and the other end 5b of the stator slot 5a extends to the circle of the second radius R2.

[0040] The radius is the first radius R1( Figure 1c The circle with a radius of the second radius R2 ( Figure 1c The circles shown in the figure are all imaginary circles, i.e., reference baselines during design and features introduced for ease of explanation, and are not real circles. Of course, the above circles can also be marked on the inner surface of the stator 10. The first radius R1 can be greater than the second radius R2.

[0041] One end of the stator slot 5a coincides with the open end of the fifth through hole 5 on the inner surface of the stator and the other end 5b of the stator slot 5a extends to the circle of the second radius R2. It can be understood that the stator slot 5a is a groove with a certain slot depth, and the two ends of the stator slot 5a are respectively located on the circle of the first radius R1 and the circle of the second radius R2, and the end located on the circle of the first radius R1 coincides with the open end of the fifth through hole 5 on the inner surface of the stator, and is connected to the open end of the fifth through hole 5 on the outer surface of the stator via the fifth through hole 5 that passes through the inner surface of the stator and the outer surface of the stator.

[0042] Reference Figure 2a and Figure 2b , the inner surface of the rotor is provided with a first rotor slot a, a second rotor slot b, a third rotor slot c, a fourth rotor slot d and a fifth rotor slot, the fifth rotor slot includes a first sub-slot e-1 and a second sub-slot e-2 connected to the first sub-slot e-1, the first rotor slot a, the second rotor slot b and the second sub-slot e-2 are spaced apart from each other, and both ends of the first rotor slot a, both ends of the second rotor slot b and both ends of the second sub-slot e-2 are respectively located on a circle of a first radius R1 and a circle of a second radius R2, the third rotor slot c, the fourth rotor slot d and the first sub-slot e-1 are spaced apart from each other, and both ends of the third rotor slot c, both ends of the fourth rotor slot d and both ends of the first sub-slot e-1 are located on a circle of a first radius R1;

[0043] The first rotor slot a, the second rotor slot b, and the second sub-slot e-2 are spaced apart from each other, which means that the first rotor slot a, the second rotor slot b, and the second sub-slot e-2 are not connected to each other. The third rotor slot c, the fourth rotor slot d, and the first sub-slot e-1 are spaced apart from each other, which means that the third rotor slot c, the fourth rotor slot d, and the first sub-slot e-1 are not connected to each other.

[0044] The fifth rotor slot includes a first sub-slot e-1 and a second sub-slot e-2 connected to the first sub-slot e-1, which means that the first sub-slot e-1 and the second sub-slot e-2 both have a free end and a connecting end, which are the free end e-11 ( Figure 2b As shown), the free end e-21 of the second sub-groove e-2 ( Figure 2b As shown), the free end e-11 and the connecting end of the first sub-groove e-1 are both located on a circle of the first radius R1, and the free end e-21 of the second sub-groove e-2 is located on a circle of the second radius R2.

[0045] Reference Figure 3a , Figure 4a , Figure 5a and Figure 6aThe first through hole 1 can be used to connect the chromatographic column, which is connected to the detector, the second through hole 2 can be used to connect the system pump, which is connected to the storage device for storing buffer solution for pumping buffer solution, the third through hole 3 and the seventh through hole 7 can be used to connect the sample loop, the fourth through hole 4 and the sixth through hole 6 can be used to connect to the waste liquid pool respectively, the fifth through hole 5 and the eighth through hole 8 can be used to connect to the injection pump respectively, for example, the eighth through hole 8 is connected to the injection pump 1, and the fifth through hole 5 is connected to the injection pump 2, and the injection pump 1 and the injection pump 2 can be different types of injection pumps.

[0046] Reference Figure 3a and Figure 3b When the injection valve is in the first state, the first rotor slot a connects the second through hole 2 and the sixth through hole 6, and at the same time, the second rotor slot b connects the first through hole 1 and the stator slot 5a. As a result, the buffer solution is sucked into the pipeline by the system pump at a large flow rate, discharged to the second through hole 2 after passing through the system pump, flows into the sixth through hole 6 through the first rotor slot a and is discharged to the waste liquid pool, realizing the flushing (PURGE) function; at the same time, the injection pump 2 injects the sample into the fifth through hole 5, flows into the first through hole 1 through the stator slot 5a and the second rotor slot b and is connected to the chromatographic column and the detector, realizing the direct injection function of the injection pump 2, thereby realizing two flow paths at the same time.

[0047] Reference Figure 4a and Figure 4b When the injection valve is in the second state, the first sub-slot e-1 of the fifth rotor slot is connected to the first through hole 1 and the second through hole 2. At the same time, the first rotor slot a is connected to the eighth through hole 8 and the seventh through hole 7, and the third rotor slot c is connected to the third through hole 3 and the fourth through hole 4. Thus, the buffer solution is sucked into the pipeline by the system pump, discharged to the second through hole 2 after passing through the system pump, discharged from the first through hole 1 through the first sub-slot e-1 and connected to the chromatographic column and the detector, completing the system detection baseline and experimental preparation work; at the same time, the injection pump 1 injects the sample into the eighth through hole 8, flows into the seventh through hole 7 through the first rotor slot a and flows into the sample ring, and flows out from the sample ring to the third through hole 3, flows into the fourth through hole 4 through the third rotor slot c and finally flows out to the waste liquid pool, completing the work of loading the sample from the injection pump 1, thereby realizing the simultaneous operation of the two flow paths.

[0048] Reference Figure 5a and Figure 5bWhen the injection valve is in the third state, the third rotor slot c connects the first through hole 1 and the second through hole 2, the second rotor slot b connects the fifth through hole 5 and the seventh through hole 7, and at the same time, the fourth rotor slot d connects the third through hole 3 and the fourth through hole 4, thereby, the buffer solution is sucked into the pipeline by the system pump, discharged to the second through hole 2 after passing through the system pump, and enters the first through hole 1 through the third rotor slot c, and is connected to the chromatographic column and the detector from the first through hole 1, completing the system detection baseline and experimental preparation work; at the same time, the injection pump 2 injects the sample into the fifth through hole 5, and enters the seventh through hole 7 through the second rotor slot b, flows out from the seventh through hole 7 to the sample ring, flows out from the sample ring to the third through hole 3, and flows into the fourth through hole 4 through the fourth rotor slot d, and finally flows out from the fourth through hole 4 to the waste liquid pool, completing the work of loading the sample from the injection pump 2, thereby realizing the simultaneous operation of the two flow paths.

[0049] The above-mentioned injection pump 2 and injection pump 1 can be injection pumps of different forms (such as different output flow rates). According to the detection needs, by switching the injection valve to the second state or the third state, the injection pump 1 or the injection pump 2 can be selected to load the sample, which is more flexible to use.

[0050] Reference Figure 6a and Figure 6b When the injection valve is in the fourth state, the third rotor slot c connects the second through hole 2 and the third through hole 3, and the fifth rotor slot connects the seventh through hole 7 and the first through hole 1. Specifically, the free end of the second sub-slot e-2 connects the seventh through hole 7, and the free end of the first sub-slot e-1 connects the first through hole 1. At the same time, the fourth rotor slot d connects the fifth through hole 5 and the fourth through hole 4. Thus, the buffer solution is sucked into the pipeline by the system pump, discharged to the second through hole 2 after passing through the system pump, and enters the third through hole 3 through the third rotor slot c. After being discharged from the third through hole, the buffer solution pushes the sample in the sample ring to flow and enter from the seventh through hole 7, and enters the first through hole 1 through the fifth rotor slot. After being discharged from the first through hole 1, it is connected to the chromatographic column and the detector to complete the injection work into the chromatographic column; at the same time, the injection pump 2 injects the medium into the fifth through hole 5, and flows into the fourth through hole 4 through the fourth rotor slot d, and then flows out to the waste liquid pool to complete the cleaning flow path work, thereby realizing the simultaneous operation of the two flow paths.

[0051] Through the layout of the through holes and slots of the stator and the rotor, when the rotor rotates relative to the stator, functions such as flushing and switching of different types of injection pumps can be achieved, thereby meeting various detection requirements without the need to disassemble pipelines and other components. This is convenient and flexible, and helps to improve detection accuracy.

[0052] In some embodiments, the stator slot 5a, the first rotor slot a, the second rotor slot b, and the second sub-slot e-2 are all straight slots.

[0053] The straight line groove is easy to process and also easy to improve the processing accuracy, thereby improving manufacturing efficiency and helping to improve reliability.

[0054] Of course, the shape of one or more of the stator slot 5a, the first rotor slot a, the second rotor slot b, and the second sub-slot e-2 may not be a straight line, for example, an arc, a curve, a broken line or other shapes.

[0055] In some embodiments, the third rotor slot c, the fourth rotor slot d and the first sub-slot e-1 are all arc slots, and the arc slots are located on a circle with a first radius R1.

[0056] The arc groove is convenient for reliable machining based on the circle of the first radius R1, and is also convenient for improving machining accuracy, thereby improving manufacturing efficiency and helping to improve reliability.

[0057] Of course, the shape of one or more of the third rotor slot c, the fourth rotor slot d and the first sub-slot e-1 may not be an arc shape, for example, it may be a straight line, a curve, a broken line or other shapes, and may not be located on a circle with the first radius R1.

[0058] In some embodiments, the injection valve also includes: a driving member (not shown in the figure), connected to the rotor 20; a controller (not shown in the figure), connected to the driving member, and the controller is configured to respond to a flushing instruction to control the driving member to drive the rotor to rotate around the rotation axis O to the first state of the injection valve, so that the first rotor slot a connects the second through hole 2 and the sixth through hole 6, and the second rotor slot b connects the stator slot 5a and the first through hole 1.

[0059] Therefore, when the flushing function is selected, the injection valve can automatically switch to the first state, thereby avoiding serious consequences such as system overpressure and damage to components such as the chromatographic column and the detector caused by forgetting to switch to the first state.

[0060] The driving member may be a driving component such as a stepping motor that can drive the rotor 20 to rotate around the rotation axis O.

[0061] For example, the controller is also connected to the system pump, and the controller is configured to respond to a flushing instruction to control the system pump to operate at an output power higher than that of the injection pump, so that the gas can be discharged efficiently and completely, thereby improving the detection accuracy.

[0062] It should be noted that, in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

Claims

1. An injection valve, comprising a stator (10) and a rotor (20), wherein the rotor is rotatable relative to the stator about a rotation axis, characterized in that: The stator comprises a stator inner surface and a stator outer surface, the stator is provided with a first through hole (1), a second through hole (2), a third through hole (3), a fourth through hole (4), a fifth through hole (5), a sixth through hole (6), a seventh through hole (7) and an eighth through hole (8) penetrating the stator inner surface and the stator outer surface, the stator inner surface is provided with a stator slot (5a), the first through hole, the second through hole, the third through hole, the fourth through hole, the fifth through hole and the eighth through hole are sequentially arranged on a circle with the rotation axis as the center and a first radius (R1), the sixth through hole and the seventh through hole are sequentially arranged on a circle with the rotation axis as the center and a second radius (R2), one end of the stator slot coincides with the fifth through hole and the other end (5b) of the stator slot extends to the circle with the second radius; The rotor comprises an inner surface of the rotor which is closely and sealedly connected to the inner surface of the stator, and the inner surface of the rotor is provided with a first rotor slot (a), a second rotor slot (b), a third rotor slot (c), a fourth rotor slot (d) and a fifth rotor slot, wherein the fifth rotor slot comprises a first sub-slot (e-1) and a second sub-slot (e-2) which is connected to the first sub-slot, the first rotor slot (a), the second rotor slot (b) and the second sub-slot (e-2) are spaced apart from each other, and two ends of the first rotor slot (a), two ends of the second rotor slot (b) and two ends of the second sub-slot (e-2) are respectively located on a circle of the first radius (R1) and a circle of the second radius (R2), the third rotor slot (c), the fourth rotor slot (d) and the first sub-slot (e-1) are spaced apart from each other, and two ends of the third rotor slot (c), two ends of the fourth rotor slot (d) and two ends of the first sub-slot (e-1) are all located on the circle of the first radius (R1).

2. The injection valve according to claim 1, characterized in that: When the rotor rotates to a first state, the first rotor slot communicates with the second through hole (2) and the sixth through hole (6), and the second rotor slot (b) communicates with the first through hole (1) and the stator slot (5a).

3. The injection valve according to claim 2, characterized in that: When the rotor rotates to the second state, the first sub-slot (e-1) of the fifth rotor slot connects the first through hole (1) and the second through hole (2), the first rotor slot (a) connects the eighth through hole (8) and the seventh through hole (7), and the third rotor slot (c) connects the third through hole (3) and the fourth through hole (4).

4. The injection valve according to claim 3, characterized in that: When the rotor rotates to the third state, the third rotor slot (c) connects the first through hole (1) and the second through hole (2), the second rotor slot connects the fifth through hole (5) and the seventh through hole (7), and the fourth rotor slot (d) connects the third through hole (3) and the fourth through hole (4).

5. The injection valve according to claim 4, characterized in that: When the rotor rotates to the fourth state, the third rotor slot (c) connects the second through hole (2) and the third through hole (3), the fifth rotor slot connects the seventh through hole (7) and the first through hole (1), and the fourth rotor slot (d) connects the fifth through hole (5) and the fourth through hole (4).

6. The injection valve according to claim 1, characterized in that: The first through hole is used to connect the chromatographic column, the second through hole is used to connect the system pump, the third through hole and the seventh through hole are used to connect the sample loop, the fourth through hole and the sixth through hole are respectively used to connect the waste liquid pool, and the eighth through hole and the fifth through hole are respectively used to connect the first injection pump and the second injection pump.

7. The injection valve according to any one of claims 1 to 6, characterized in that: The first rotor slot (a), the second rotor slot (b), and the second sub-slot (e-2) are all linear slots.

8. The injection valve according to claim 7, characterized in that: The third rotor slot (c), the fourth rotor slot (d) and the first sub-slot (e-1) are all arc slots, and the arc slots are located on a circle with the first radius.

9. The injection valve according to claim 1, characterized in that: The first radius is greater than the second radius.

10. The injection valve according to claim 2, characterized in that: The injection valve also includes: A driving member connected to the rotor; The controller is connected to the driving member, and is configured to control the driving member to drive the rotor to rotate around the rotation axis to the first state in response to a flushing instruction from a user.

Citation Information

Patent Citations

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    CN110927299A

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    CN115639304A

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