Insecticidal composition containing cyprosulfuron and application thereof

Abstract

The invention discloses an insecticidal composition containing cyprosulfuron and application of the insecticidal composition. The effective components of the insecticidal composition are composed of cyprosulfuron and pyrethroid, wherein the pyrethroid is perfluthrin, dimefluthrin, trifluthrin, dextro-trans-propargyl chloride pyrethrin, perfluthrin, dextro-phenothrin, dextro-tefluthrin, chlorenthrin, beta-cypermethrin, meperfluthrin, bifenthrin, deltamethrin, cis-cypermethrin and beta-cyhalothrin, and the pyrethroid is a mixture of dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin, dimefluthrin and dimefluthrin. Any one of beta-cyfluthrin and beta-cyfluthrin; the total weight of the cyprosulfuron and the pyrethroid accounts for 2.2%-40% of the insecticidal composition, and the weight ratio of the cyprosulfuron to the pyrethroid is (10: 1)-(1: 2). The pesticide has the characteristics of high efficiency, low toxicity and the like, is used for space spraying or retention spraying, is quick in effect, thorough in killing and long in lasting period, reduces the pesticide application amount, and reduces the pesticide application irritation. The composition can be widely applied to hotels, schools, factories, farms, families and public places, and has a special effect on preventing and treating sanitary pests.

Description

Technical Field

[0001] The invention relates to an insecticidal composition containing ciprofloxacin and application thereof. The effective ingredients of the insecticidal composition consist of ciprofloxacin and pyrethroids, wherein the pyrethroids are one or more of cypermethrin, tetrafluthrin, metofluthrin, d-trans-chlorprothrin, transfluthrin, d-phenothrin, d-heptafluthrin, chlorfenapyr, high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin and high-efficiency cyfluthrin. Background Art

[0002] Cyproflanilide (ISO common name: Cyproflanilide, CAS: 2375110-88-4) has the characteristics of high efficiency, broad insecticidal spectrum, good penetration, rapid onset and long lasting effect. It can effectively control Lepidoptera, Coleoptera and Thysanoptera pests. Studies have shown that it also has good activity against sanitary pests.

[0003] Pyrethroids have stomach poison, contact killing and fumigation effects. They are good knockdown agents and lethal agents and are widely used in the field of sanitary external environment space spraying and residual spraying.

[0004] At present, sanitary pests have a high degree of resistance to pyrethroids, and it is easy for pests to revive after being knocked down. To address this dilemma, we considered compounding ciprofloxacin with pyrethroids. On the one hand, the two have different mechanisms of action, and there is no cross-resistance when compounded, which can solve the problem of resistance of sanitary pests to pyrethroids and reduce the amount of pesticides applied. On the other hand, ciprofloxacin has basically no irritation to the skin, which improves the safety of applicators.

[0005] At the same time, reducing the irritation of drugs is a difficult point in current research. Generally, it can be achieved by encapsulating the original drug and performing sustained-release treatment, such as microcapsule suspension. Although this can reduce the irritation of the drug to the skin in the short term, the efficacy will be affected. Therefore, how to reduce the irritation of the drug solution to the skin while ensuring the efficacy is what we urgently need to study. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide an insecticidal composition containing ciprofloxacin and its application in view of the deficiencies in the prior art. The composition of the present invention compounds ciprofloxacin with pyrethroids, has good insecticidal effect, low medication cost, has synergistic effect and is not easy to produce drug resistance, and some dosage forms are added with irritation relief agent components to reduce the irritation of the agent to the skin and improve safety.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] The present invention first provides an insecticidal composition containing ciprofloxacin, wherein the active ingredients are ciprofloxacin and pyrethroids, and the total weight of ciprofloxacin and pyrethroids accounts for 2.2% to 40% of the total weight of the insecticidal composition, and the remainder is auxiliary materials;

[0009] The pyrethroid is selected from any one of cypermethrin, tetrafluthrin, metofluthrin, d-trans-chlorprophagen, transfluthrin, d-phenothrin, d-heptafluthrin, chlorfenapyr, high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin, and high-efficiency cyfluthrin.

[0010] In the above technical solution, the weight ratio of cyfluthrin to pyrethroid is 10:1 to 1:2, wherein:

[0011] The weight ratio of cyfluthrin to tetrafluthrin is preferably 10:1;

[0012] The weight ratio of cyfluthrin to tetrafluthrin is preferably 10:1;

[0013] The weight ratio of cyfluthrin to metofluthrin is preferably 10:1;

[0014] The weight ratio of cyfluthrin to d-trans-chlorpromazine is preferably 6:1;

[0015] The weight ratio of cyfluthrin to transfluthrin is preferably 6:1;

[0016] The weight ratio of cyfluthrin to phenothrin is preferably 2:1;

[0017] The weight ratio of cyfluthrin to dexamethasone is preferably 10:1;

[0018] The weight ratio of cyfluthrin to chlorpyrifos is preferably 6:1;

[0019] The weight ratio of cyfluthrin to cypermethrin is preferably 1:2;

[0020] The weight ratio of cyfluthrin to chlorfluanid is preferably 6:1;

[0021] The weight ratio of cyfluthrin to bifenthrin is preferably 1:1;

[0022] The weight ratio of cyfluthrin to deltamethrin is preferably 1:1;

[0023] The weight ratio of cyflumitriptyline to cis-cypermethrin is preferably 1:1;

[0024] The weight ratio of cyfluthrin to cyhalothrin is preferably 1:1;

[0025] The weight ratio of cyfluthrin to benzyl-cypermethrin is preferably 1:2.

[0026] In the above technical solution, the auxiliary material is a mixture of any two or more of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, irritation relief agents, disintegrants, binders, water, and fillers in any proportion.

[0027] In the above technical solution, the insecticidal composition containing cyfluthrin is in the form of emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid, thermal fog, wettable powder, water-dispersible granules or suspension.

[0028] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of emulsifiable concentrate, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 1%-5% pyrethroid, 8%-15% emulsifier, and the solvent is supplemented to 100%.

[0029] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of an aqueous emulsion, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 0.1%-5% pyrethroid, 15%-25% solvent, 10%-15% emulsifier, 3%-6% antifreeze agent, 0.1%-0.5% defoamer, and water is supplemented to 100%.

[0030] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of a microemulsion, comprises the following raw materials in weight percentage: 1%-5% ciprofloxacin, 0.1%-3% pyrethroid, 15%-30% emulsifier, 15%-25% solvent, and water is supplemented to 100%.

[0031] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of a soluble liquid, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 0.1%-5% pyrethroid, 15%-30% emulsifier, and the solvent is supplemented to 100%.

[0032] In the above technical solution, the insecticidal composition containing ciprofloxacin, when in the form of a thermal fog agent, comprises the following raw materials in weight percentage: 1%-5% ciprofloxacin, 0.1%-2% pyrethroid, and the solvent is supplemented to 100%.

[0033] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of a suspension, comprises the following raw materials in weight percentage: 4%-20% ciprofloxacin, 2%-12% pyrethroid, 4%-10% dispersant, 1%-5% wetting agent, 0.1%-3% thickener, 0.1%-2% preservative, 1%-5% antifreeze agent, 1%-5% irritation relief agent, 0.1%-0.5% defoaming agent, and water is supplemented to 100%.

[0034] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 5%-18% ciprofloxacin, 2%-20% pyrethroid, 5%-10% dispersant, 1-5% wetting agent, and the filler is supplemented to 100%.

[0035] In the above technical scheme, the insecticidal composition containing ciprofloxacin, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 10%-20% ciprofloxacin, 10%-25% pyrethroid, 5%-10% dispersant, 2%-6% wetting agent, 5%-10% disintegrant, 0.1%-0.5% binder, and the filler is supplemented to 100%.

[0036] In the above scheme, the solvent is selected from: one or more of trimethylbenzene, tetramethylbenzene, pentamethylbenzene, ethanol, cyclohexanone, odorless kerosene, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylhexylamide, N-methylpyrrolidone, diisopropyl adipate, tributyl citrate, acetyl tributyl citrate, ethylene glycol methyl ether, piperonyl butoxide, and dodecylbenzene.

[0037] In the above scheme, the emulsifier is selected from: styrylphenol polyoxyethylene ether (such as Nongru 600# series), calcium dodecylbenzene sulfonate (such as Nongru 500# of Nanjing Taihua Co., Ltd.), OP series phosphate (alkylphenol polyoxyethylene ether phosphate), phenylphenol polyoxyethyl ether phosphate (such as 600# phosphate of Jiangsu Kaiyuan), styrylphenol polyoxyethylene ether ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, benzyl dimethylphenol polyoxyethyl ether (such as Nongru 400#), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), benzene One or more of ethylphenol polyoxyethyl polypropylene ether (such as Nongru 1600#), ethylene oxide-propylene oxide block copolymer, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether (such as Jiangsu Kaiyuan's EL series), alkylaryl polyoxypropylene polyoxyethylene ether (such as Nanjing Taihua's Nongru 33#), alkylaryl polyoxyethylene polyoxypropylene ether (such as Nanjing Taihua's Nongru 34#), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether), fatty alcohol polyoxyethylene ether (such as Hai'an Petrochemical MOA series).

[0038] In the above scheme, the dispersant is selected from: one or more of acrylic acid-(meth)acrylate copolymer, sodium methylene bisnaphthalene sulfonate, sodium lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene sulfonate calcium salt, naphthalenesulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether.

[0039] In the above scheme, the wetting agent is selected from: one or more of alkylbenzene polyoxyethylene ether phosphate, phenylethylphenol polyoxyethylene ether phosphate, sodium alkyl sulfonate, sodium dodecyl sulfate, opening powder BX, wetting and penetrating agent F, detergent LS, and sodium dodecylbenzene sulfonate.

[0040] In the above scheme, the defoaming agent can be one or more of silicone oil and polydimethylsiloxane.

[0041] In the above scheme, the antifreeze agent can be one or more of ethylene glycol, propylene glycol, and glycerol.

[0042] In the above scheme, the preservative is selected from one or more of potassium sorbate and sodium benzoate.

[0043] In the above scheme, the thickener is selected from: one or more of xanthan gum, hydroxyethyl cellulose, and magnesium aluminum silicate.

[0044] In the above scheme, the irritation-relief agent can be any one of methyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, phosphatidylethanolamine, phosphatidylglycerol, and maltodextrin, or a mixture of two or more of them in any proportion. The irritation-relief agent in the present invention can at least ensure that the skin will not feel irritation during the 4-hour application process, and the skin will not feel irritation after washing after 4 hours.

[0045] In the above scheme, the disintegrant is selected from: one or more of ammonium sulfate, sodium sulfate, urea, sodium bicarbonate, and sodium carbonate.

[0046] In the above scheme, the binder is selected from: one or more of methyl cellulose, polyvinyl pyrrolidone, and sodium alginate.

[0047] In the above scheme, the filler is selected from: one or more of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate.

[0048] In the above technical scheme, when the sanitary insecticide composition is in the form of emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid, thermal fog, wettable powder, water dispersible granules or suspension, it can be prepared according to conventional methods or existing methods in the art.

[0049] The present invention also provides an application of the insecticidal composition containing cyprodinil in the field of sanitary pests for controlling sanitary pests by space spraying or residual spraying.

[0050] In the above technical solution, the sanitary pest field refers to hotels, schools, factories, farms, homes, and public places.

[0051] In the above technical scheme, the sanitary pests are mosquitoes, flies, etc., specifically referring to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argonautus harassingus, Chironomids, housefly, city fly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia bright, summer toilet fly, Yuan toilet fly, bed bug, human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas or scabies.

[0052] In the above technical scheme, when the insecticide composition containing cyprodinil is used to control sanitary pests in the field of sanitary pests by space spraying, the method of use is: (1) directly using the insecticide composition, using a thermal fog machine to spray the liquid into the space; (2) diluting the insecticide composition with water by 20-40 times, and using an ultra-low volume device to spray the liquid into the space; (3) diluting the insecticide composition with water by 50-200 times, and using a constant volume spray device to spray the liquid into the space.

[0053] In the above technical scheme, when the insecticide composition containing cyprodinil is used to control sanitary pests in the field of sanitary pests by residual spraying, the method of use is: dilute the insecticide composition with water by 50-200 times, and use a constant spray equipment to spray the liquid on the ground, wall, railing, fence surface, etc.

[0054] Compared with the existing technology, it has the following characteristics:

[0055] (1) The first application of cyfluthrin in the control of sanitary pests;

[0056] (2) The synergistic effect of compounding with pyrethroids is obvious, which reduces the dosage of pesticides;

[0057] (3) Irritation reducing agents are added to the formula to reduce skin irritation and make it safer for applicators. DETAILED DESCRIPTION

[0058] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0059] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0060] The laboratory preparation method of emulsifiable concentrate is as follows: weigh the original drug, emulsifier and solvent in proportion, heat and mix them evenly in a beaker, and then the concentrate can be prepared.

[0061] The laboratory preparation method of water-in-water emulsion is as follows: weigh the original drug, emulsifier, and solvent in proportion, heat and dissolve them to form an oil phase, weigh the antifreeze, defoaming agent and water in proportion and mix them to form an aqueous phase, and slowly add the aqueous phase to the oil phase under high-speed shear conditions to prepare the water-in-water emulsion.

[0062] The laboratory preparation method of microemulsion is: weigh the original drug, emulsifier, and solvent in proportion, heat and dissolve them completely, add water under stirring, and stir evenly to obtain the microemulsion.

[0063] Soluble liquid: Weigh the original drug, emulsifier and solvent in proportion, heat and fully dissolve them to obtain a soluble liquid.

[0064] Thermal fog agent: Weigh the original drug and solvent in proportion, heat and dissolve them completely to produce the thermal fog agent.

[0065] The laboratory preparation method of wettable powder is: weigh the original drug, wetting agent, dispersant and filler in proportion, add them into a mixer and mix them evenly, and then grind them in a jet mill to obtain the wettable powder.

[0066] The laboratory preparation method of water-dispersible granules is as follows: weigh the original drug, wetting agent, dispersant, disintegrant and filler in proportion, add them into a mixer and mix them evenly, grind them with a jet mill, use the mixer again, add water and a binder mixture, extrude and granulate them with a granulator, and dry them to obtain the product.

[0067] The laboratory preparation method of the suspension is as follows: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, irritation relief agent, and defoaming agent in proportion, mix them evenly, add the original drug, shear them with a high-speed shearing machine for 5 minutes, and then transfer them to a sand mill for sand grinding for 2-3 hours to control the particle size D90 below 5μm to obtain the suspension.

[0068] The present invention will be described below in conjunction with specific embodiments:

[0069] Formulation Example 1: 11% cyprodinil·methofluthrin emulsifiable concentrate

[0070] 10g of cyprodinil, 1g of metofluthrin, 6g of calcium dodecylbenzene sulfonate, 4g of castor oil polyoxyethylene ether, 2g of phenylphenol polyoxyethyl ether phosphate, 15g of tetramethylbenzene, and make up to 100g of N,N-dimethylacetamide.

[0071] Formulation Example 2: 5.5% cyprodinil·methofluthrin emulsion in water

[0072] 5g of ciprofloxacin, 0.5g of metofluthrin, 8g of N,N-dimethylacetamide, 8g of cyclohexanone, 4g of phenylphenol polyoxyethyl ether phosphate, 5g of castor oil polyoxyethylene ether, 2g of ethylene oxide-propylene oxide block copolymer, 5g of ethylene glycol, 0.2g of polydimethylsiloxane, and make up to 100g with water.

[0073] Formulation Example 3: 3.5% cyprodinil·transfluthrin microemulsion

[0074] 3g of cyprodinil, 0.5g of transfluthrin, 2g of calcium dodecylbenzenesulfonate, 3g of fatty alcohol polyoxyethylene ether, 18g of castor oil polyoxyethylene ether, 12g of N-methylpyrrolidone, 6g of N,N-dimethylpropionamide, and make up to 100g with water.

[0075] Formulation Example 4: 7% cyprodinil·transfluthrin soluble liquid

[0076] 6g of cyprodinil, 1g of transfluthrin, 4g of calcium dodecylbenzenesulfonate, 10g of castor oil polyoxyethylene ether, 6g of styrylphenol polyoxyethylene ether, 12g of tributyl citrate, 2g of piperonyl butoxide, and make up to 100g of N,N-dimethylpropionamide.

[0077] Formulation Example 5: 21% cyfluthrin-chlorfenapyr wettable powder

[0078] 18g of cyfluthrin, 3g of chlorfluanid, 2g of sodium dodecylbenzene sulfonate, 2g of detergent LS, 6g of sodium lignin sulfonate, 12g of white carbon black, and kaolin to 100g.

[0079] Formulation Example 6: 14% cyprodinil·chlorfluanidine suspension

[0080] 12g of cyfluthrin, 2g of chlorfluanidine, 2g of sodium alkyl sulfonate, 2g of sodium lauryl sulfate, 3g of acrylic acid-(meth)acrylate copolymer, 4g of sodium lignin sulfonate, 1.5g of magnesium aluminum silicate, 0.2g of xanthan gum, 5g of propylene glycol, 0.5g of potassium sorbate, 1.5g of methyl-β-cyclodextrin, 0.3g of polydimethylsiloxane, and make up to 100g with water.

[0081] Formulation Example 7: 12% cyprodinil·d-phenothrin emulsifiable concentrate

[0082] 8g of cyprodinil, 4g of dextrorotatory phenoxyacetate, 5g of calcium dodecylbenzenesulfonate, 4g of Ningru 36#, 2g of phenylphenol polyoxyethyl ether phosphate, 12g of diisopropyl adipate, and N,N-dimethylacetamide made up to 100g.

[0083] Formulation Example 8: 9% cyprodinil·d-phenothrin soluble liquid

[0084] 6g of cyprodinil, 3g of dextromethorphine, 4g of calcium dodecylbenzenesulfonate, 10g of castor oil polyoxyethylene ether, 8g of agricultural milk 34#, 2g of fatty alcohol polyoxyethylene ether, 5g of piperonyl butoxide, and N,N-dimethylacetamide made up to 100g.

[0085] Formulation Example 9: 11% cyprodinil·dexflumethrin emulsifiable concentrate

[0086] 10g of cyprodinilfluanid, 1g of dextrorotatory heptafluoromethyl ether, 6g of calcium dodecylbenzene sulfonate, 3g of styrylphenol polyoxyethylene ether, 5g of castor oil polyoxyethylene ether, 40g of pentamethylbenzene, and make up to 100g of N,N-dimethylacetamide.

[0087] Formulation Example 10: 5.5% cyprodinil·dexaflumethrin emulsion in water

[0088] 5g of cyfluthrin, 0.5g of dextromethorphine, 15g of N,N-dimethyltetracycline, 6g of cyclohexanone, 4g of alkylphenol polyoxyethylene ether phosphate, 5g of castor oil polyoxyethylene ether, 3g of calcium dodecylbenzene sulfonate, 5g of ethylene glycol, 0.2g of polydimethylsiloxane, and make up to 100g with water.

[0089] Formulation Example 11: 30% cyfluthrin-cyhalothrin water dispersible granules

[0090] 15g of cyfluthrin, 15g of cypermethrin, 2g of BX powder, 2g of detergent LS, 6g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 5g of ammonium sulfate, 0.5g of methyl cellulose, 10g of white carbon black, and 100g of kaolin.

[0091] Formulation Example 12: 12% cyfluthrin-cyhalothrin suspension

[0092] 6g of cyfluthrin, 6g of cypermethrin, 1.5g of sodium lauryl sulfate, 3.5g of acrylic acid-(meth)acrylate copolymer, 4.5g of sodium lignin sulfonate, 1g of magnesium aluminum silicate, 0.3g of xanthan gum, 1.5g of hydroxypropyl-β-cyclodextrin, 3g of glycerol, 0.5g of potassium sorbate, 0.3g of silicone oil, and make up to 100g with water.

[0093] Formulation Example 13: 36% cyprodinil·beta-cypermethrin water dispersible granules

[0094] 12g of cyfluthrin, 24g of high-efficiency flucythrin, 2g of detergent LS, 3g of sodium dodecyl sulfate, 3g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 5g of sodium lignin sulfonate, 8g of sodium sulfate, 0.3g of polyvinylpyrrolidone, and kaolin is made up to 100g.

[0095] Formulation Example 14: 18% cyfluthrin-cypermethrin suspension

[0096] 6g of cyfluthrin, 12g of high-efficiency flucythrin, 2g of sodium alkyl sulfonate, 2g of alkylphenol polyoxyethylene ether, 4g of acrylic acid-(meth)acrylate copolymer, 4g of sodium lignin sulfonate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 2g of phosphatidylethanolamine, 5g of propylene glycol, 0.5g of sodium benzoate, 0.3g of silicone oil, and make up to 100g with water.

[0097] Formulation Example 15: 21% cyprodinil·D-trans-chlorpromazine wettable powder

[0098] 18g of cyfluthrin, 3g of right-rotating trans-chlorpromazine, 2g of sodium lauryl sulfate, 2g of detergent LS, 8g of sodium lignin sulfonate, 10g of white carbon black, and 100g of diatomaceous earth

[0099] Formulation Example 16: 3.5% cyprodinil·d-trans-chlorpromazine microemulsion

[0100] 3g of cyfluthrin, 0.5g of right-rotating trans-chlorpropamide, 4g of calcium dodecylbenzenesulfonate, 18g of castor oil polyoxyethylene ether, 15g of N,N-dimethylacetamide, 5g of ethanol, and make up to 100g with water.

[0101] Formulation Example 17: 30% cyprodinil·cypermethrin wettable powder

[0102] 10g of cypermethrin, 20g of chlorpyrifos, 3g of sodium dodecyl sulfate, 2g of detergent LS, 4g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4g of sodium lignin sulfonate, and clay added to 100g.

[0103] Formulation Example 18: 12% cyprodinil·cypermethrin suspension

[0104] 4g of cypermethrin, 8g of chlorpyrifos, 2g of sodium alkyl sulfonate, 1.5g of fatty amine polyoxyethylene ether, 3g of acrylic acid-(meth)acrylate copolymer, 3g of sodium lignin sulfonate, 1g of magnesium aluminum silicate, 0.2g of xanthan gum, 2g of phosphatidylglycerol, 4g of ethylene glycol, 0.5g of sodium benzoate, 0.3g of silicone oil, and make up to 100g with water.

[0105] Formulation Example 19: 2.2% cyprodinil·tetrafluthrin thermal fog

[0106] 2g of cyfluthrin, 0.2g of tetrafluthrin, 25g of diisopropyl adipate, 15g of N,N-dimethylacetamide, and make up to 100g of odorless kerosene.

[0107] Formulation Example 20: 22% cyfluthrin-tetrafluthrin suspension

[0108] 20g of cyfluthrin, 2g of tetrafluthrin, 2g of alkylphenol polyoxyethylene ether, 4g of acrylic acid-(meth)acrylate copolymer, 4g of sodium alkyl sulfonate, 0.25g of xanthan gum, 0.5g of magnesium aluminum silicate, 0.5g of potassium sorbate, 2.5g of phosphatidylethanolamine, 4g of glycerol, 0.2g of silicone oil, and make up to 100g with water.

[0109] Formulation Example 21: 2.2% cyprodinil·tetrafluthrin thermal spray

[0110] 2g of cyfluthrin, 0.2g of tetrafluthrin, 25g of diisopropyl adipate, 15g of N,N-dimethylacetamide, and make up to 100g of odorless kerosene.

[0111] Formulation Example 22: 14% cyprodinil·chlorfenapyr wettable powder

[0112] 12g of cyfluthrin, 2g of chlorpyrifos, 2g of detergent LS, 4g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4g of sodium lignin sulfonate, 3g of white carbon black, and diatomaceous earth made up to 100g.

[0113] Formulation Example 23: 30% cyprodinil·bifenthrin wettable powder

[0114] 15g of cyprodinil, 15g of cypermethrin, 2g of detergent LS, 1g of sodium dodecyl sulfate, 4g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 2g of sodium methylene bisnaphthalenesulfonate, 10g of white carbon black, and kaolin made up to 100g.

[0115] Formulation Example 24: 20% cyprodinil·bifenthrin suspension

[0116] 10g of cyprodinil, 10g of cypermethrin, 3g of sodium lauryl sulfate, 2g of fatty amine polyoxyethylene ether, 3g of acrylic acid-(meth)acrylate copolymer, 4g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 1g of magnesium aluminum silicate, 0.15g of xanthan gum, 3g of maltodextrin, 4g of ethylene glycol, 0.4g of potassium sorbate, 0.2g of polydimethylsiloxane, and make up to 100g with water.

[0117] Formulation Example 25: 20% cyprodinil·deltamethrin wettable powder

[0118] 10g of cyfluthrin, 10g of cypermethrin, 2g of detergent LS, 1g of sodium lauryl sulfate, 5g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4g of sodium lignin sulfonate, 8g of white carbon black, and clay made up to 100g.

[0119] Formulation Example 26: 12% cyprodinil·deltamethrin suspension

[0120] 6g of cyprodinil, 6g of cypermethrin, 3g of sodium dodecyl sulfate, 1g of alkylbenzene polyoxyethylene ether phosphate, 2g of fatty amine polyoxyethylene ether, 4g of acrylic acid-(meth)acrylate copolymer, 1g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 0.3g of hydroxyethyl cellulose, 2g of methyl-β-cyclodextrin, 4g of propylene glycol, 0.4g of potassium sorbate, 0.3g of polydimethylsiloxane, and make up to 100g with water.

[0121] Formulation Example 27: 40% cyprodinil·cis-cypermethrin water dispersible granules

[0122] 20g of cyfluthrin, 20g of cis-cypermethrin, 2g of detergent LS, 4g of sodium dodecyl sulfate, 4g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 6g of sodium lignin sulfonate, 10g of urea, 0.1g of polyvinylpyrrolidone, and corn starch is added to 100g.

[0123] Formulation Example 28: 10% cyprodinil·cis-cypermethrin suspension

[0124] 5g of cyprodinil, 5g of cis-cypermethrin, 2g of sodium dodecyl sulfate, 3g of acrylic acid-(meth)acrylate copolymer, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 1g of magnesium aluminum silicate, 0.25g of xanthan gum, 1.5g of hydroxypropyl-β-cyclodextrin, 3g of propylene glycol, 0.5g of potassium sorbate, 0.3g of silicone oil, and make up to 100g with water.

[0125] Comparative Example 1: 12% cyfluthrin-cyhalothrin suspension

[0126] 6g of cyfluthrin, 6g of cypermethrin, 1.5g of sodium lauryl sulfate, 3.5g of acrylic acid-(meth)acrylate copolymer, 4.5g of sodium lignin sulfonate, 1g of magnesium aluminum silicate, 0.3g of xanthan gum, 3g of glycerol, 0.5g of potassium sorbate, 0.3g of silicone oil, and make up to 100g with water.

[0127] The present invention will be described below in conjunction with specific experiments:

[0128] Application Example 1: Indoor Efficacy Test of Spraying for Controlling Mosquitoes and Flies

[0129] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0130] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0131] Test method: refer to GB / T 13917.10-2009, simulate the site, and use the simulated room hanging cage method to conduct the test;

[0132] Application method: Ultra-low volume spray

[0133] Dosage setting: The spraying concentration of the active ingredient in the preparation examples is 1.5 mg / m3;

[0134] Control sample 1: 10.4% chlorpyrifos·allethrin emulsion (commercially available), spraying dosage 1.5 mg / m3;

[0135] Control sample 2: 5% chlorpyrifos·permethrin emulsion (commercially available), spraying dose 1.5 mg / m3;

[0136] Test results:

[0137] Table 1: Test on the efficacy of space spraying of formulation examples against Culex pipiens pallens and houseflies

[0138]

[0139] The test results show that the above-mentioned formulation examples are superior to control sample 1 (10.4% chlorpyrifos·allethrin emulsion) and control sample 2 (5% chlorpyrifos·permethrin emulsion) in knockdown effect against Culex pipiens pallens and housefly, and the 24h lethality is above 96%, among which the lethality of formulation examples 1, 3, 9 and 16 all reach 100% (see Table 1). It can be seen that the efficacy of the formulation examples is superior to or equivalent to the efficacy of the mainstream space sprays currently on the market.

[0140] Application Example 2: Indoor Efficacy Test of Residual Spraying for Controlling Mosquitoes and Flies

[0141] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0142] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0143] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0144] Test surface: glass board, varnished wood board, gypsum board;

[0145] Dosage setting: The total concentration of active ingredients in the preparation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0146] Control sample 1: 15% chlorofluoroether·cischloride wettable powder (commercially available) diluted to 200 mg / l;

[0147] Control sample 2: 12% chlorpyrifos wettable powder (commercially available) diluted to 200 mg / l;

[0148] Test results:

[0149] Table 2 Residual spraying efficacy test of formulation examples against Culex pipiens pallens and housefly

[0150]

[0151]

[0152] The test results show that by reducing the dosage by half, the 30-day efficacy on the glass surface can reach more than 80%, on the wood surface, the 30-day efficacy can reach more than 75%, and on the gypsum board surface, the 30-day efficacy can reach more than 55%, which is significantly better than the control sample 1 and the control sample 2. (See Table 2).

[0153] Application Example 3: Determination of the co-toxicity coefficient of cyprodinil and pyrethroids

[0154] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0155] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0156] Table 3 Determination of the co-toxicity coefficient of cyprodinil and metofluthrin (for houseflies)

[0157]

[0158] As shown in Table 3, when the ratio of ciprofloxacin to methicillin was 20:1 to 1:1, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 10:1, the synergistic effect was most obvious.

[0159] Table 4 Determination of the co-toxicity coefficient of cyprodinil and transfluthrin (for houseflies)

[0160]

[0161] As shown in Table 4, when the ratio of ciprofloxacin to transfluthrin was 20:1 to 1:6, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 6:1, the synergistic effect was most obvious.

[0162] Table 5 Determination of the co-toxicity coefficient of cyfluthrin and chlorfluthrin (for houseflies)

[0163]

[0164]

[0165] As shown in Table 5, when the ratio of ciprofloxacin to chlorfenapyr was 20:1 to 1:2, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 6:1, the synergistic effect was most obvious.

[0166] Table 6 Determination of the co-toxicity coefficient of cyprodinil and d-trans chlorpromazine (for houseflies)

[0167]

[0168] As shown in Table 6, when the ratio of ciprofloxacin to 2-trans-chlorpropylthrin was 20:1 to 1:6, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 6:1, the synergistic effect was most obvious.

[0169] Table 7 Determination of the co-toxicity coefficient of cyfluthrin and cypermethrin (for houseflies)

[0170]

[0171]

[0172] As shown in Table 7, when the ratio of ciprofloxacin to high-efficiency chlorpyrifos was 6:1 to 1:10, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 1:2, the synergistic effect was most obvious.

[0173] Table 8 Optimal co-toxicity coefficient of bromofenac and other pyrethroids (for houseflies)

[0174]

[0175] As can be seen from Table 8, the optimal ratios of ciprofloxacin and other pyrethroids were all in the range of 10:1 to 1:2, the co-toxicity coefficients were all above 130, and the synergistic effect was obvious.

[0176] Application Example 4: Skin Irritation Verification Test

[0177] Test method: Use the method of applying diluted solution on the skin to compare the irritation between different drugs

[0178] Test agent: Preparation Example 12; Control Example 1;

[0179] Control: 25g / L highly effective cyhalothrin microcapsule suspension (Syngenta Damothrin)

[0180] Dosage setting: 800 mg / L (active ingredient) for Preparation Example 12 and Control Example 1;

[0181] The control is 400 mg / L (active ingredient), ensuring that the dosage of cyhalothrin in the formulation example and the control is 400 mg / L.

[0182] Test steps: Use a pipette to take 30 μL of the diluted solution and apply it to the back of the left hand, the back of the right hand, the left cheek and the right cheek, and feel the degree of skin irritation of the solution for 2 hr, 4 hr, 8 hr and 12 hr. According to the application habits, the application staff will wash the skin once every half a day (about 4 hours). Therefore, in order to simulate the actual application situation, the skin in contact with the solution is washed with cold water at 4 hours.

[0183] Table 9 Irritation Verification (I)

[0184]

[0185] Table 10 Irritation Verification (II)

[0186]

[0187] The test results show that the diluted solution of Preparation Example 12, which contains an irritation-reducing agent, has greatly improved skin irritation and is comparable to the microcapsule suspension.

[0188] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. An insecticidal composition containing cyprodinil, characterized in that: The active ingredients are ciprofloxacin and pyrethroids, and the total weight of ciprofloxacin and pyrethroids accounts for 2.2% to 40% of the total weight of the insecticide composition, and the remainder is auxiliary materials; The pyrethroid is selected from any one of cypermethrin, tetrafluthrin, metofluthrin, d-trans-chlorprophagen, transfluthrin, d-phenothrin, d-heptafluthrin, chlorfenapyr, high-efficiency cypermethrin, cyfluthrin, bifenthrin, deltamethrin, cis-cypermethrin, high-efficiency cyhalothrin, and high-efficiency cyfluthrin.

2. The insecticidal composition according to claim 1, characterized in that The weight ratio of ciprofloxacin to pyrethroid is 10:1 to 1:

2.

3. The insecticidal composition according to claim 1, characterized in that The auxiliary material is a mixture of any two or more of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, irritation relief agents, disintegrants, binders, water, and fillers in any proportion; the insecticide composition containing cyprodinil is in the form of emulsifiable concentrates, aqueous emulsions, microemulsions, soluble liquids, thermal fog agents, wettable powders, water-dispersible granules or suspensions.

4. The insecticidal composition according to claim 3, characterized in that The insecticide composition containing ciprofloxacin, when in the form of emulsifiable concentrate, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 1%-5% pyrethroid, 8%-15% emulsifier, and the solvent is supplemented to 100%; the insecticide composition containing ciprofloxacin, when in the form of aqueous emulsion, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 0.1%-5% pyrethroid, 15%-25% solvent, 10%-15% emulsifier, 3%-6% antifreeze, 0.1%-0.5% defoamer, and water is supplemented to 100%.

5. The insecticidal composition according to claim 3, characterized in that: The insecticide composition containing ciprofloxacin, when in the form of a microemulsion, comprises the following raw materials in weight percentage: 1%-5% ciprofloxacin, 0.1%-3% pyrethroid, 15%-30% emulsifier, 15%-25% solvent, and water makes up to 100%; the insecticide composition containing ciprofloxacin, when in the form of a soluble liquid, comprises the following raw materials in weight percentage: 1%-10% ciprofloxacin, 0.1%-5% pyrethroid, 15%-30% emulsifier, and solvent makes up to 100%.

6. The insecticidal composition according to claim 3, characterized in that: The insecticide composition containing ciprofloxacin, when in the form of a thermal fog agent, comprises the following raw materials in weight percentage: 1%-5% ciprofloxacin, 0.1%-2% pyrethroid, and the solvent is supplemented to 100%; the insecticide composition containing ciprofloxacin, when in the form of a suspension, comprises the following raw materials in weight percentage: 4%-20% ciprofloxacin, 2%-12% pyrethroid, 4%-10% dispersant, 1%-5% wetting agent, 0.1%-3% thickener, 0.1%-2% preservative, 1%-5% antifreeze agent, 1%-5% irritation relief agent, 0.1%-0.5% defoamer, and water is supplemented to 100%.

7. The insecticidal composition according to claim 3, characterized in that: The insecticide composition containing ciprofloxacin, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 5%-18% ciprofloxacin, 2%-20% pyrethroid, 5%-10% dispersant, 1-5% wetting agent, and the filler is supplemented to 100%; the insecticide composition containing ciprofloxacin, when in the form of a water-dispersible granule, comprises the following raw materials in weight percentage: 10%-20% ciprofloxacin, 10%-25% pyrethroid, 5%-10% dispersant, 2%-6% wetting agent, 5%-10% disintegrant, 0.1%-0.5% binder, and the filler is supplemented to 100%.

8. The insecticidal composition according to claim 3, characterized in that: The irritation-relief agent can be any one of methyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, phosphatidylethanolamine, phosphatidylglycerol, and maltodextrin, or a mixture of two or more of them in any proportion; the irritation-relief agent in the present invention, after being added, can at least ensure that the skin will not feel irritation during the 4-hour application process, and the skin will not feel irritation after washing after 4 hours.

9. Use of the insecticidal composition containing cyfluthrin as claimed in claim 1 in controlling sanitary pests by space spraying or residual spraying.

10. The use according to claim 9, characterized in that: The field of sanitary pests refers to hotels, schools, factories, farms, households, and public places; the sanitary pests refer to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argonautus harassingus, Chironomids, housefly, city fly, Chrysocybe megacephala, Lucilia sericata, Lucilia cuprina, Lucilia brighten, summer toilet fly, toilet fly, bed bug, human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas or scabies.

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