Application of Jindan attached-extension compound in treatment of lymphatic cyst caused by pelvic tumor operation

Abstract

The invention discloses an application of a Jindan attached-extension compound as a traditional Chinese medicine preparation for treating lymphatic cyst caused by pelvic tumor surgery. The medicine has the main effects of reducing the permeability of blood vessels, accelerating the establishment of lymphatic side limb circulation, enhancing the absorption capacity of chest and peritoneum and promoting centripetal reflux of lymph. The conventional preparation of the Jindan attached-delay compound is Jindan attached-delay particles. According to the present invention, the treatment effect on the lymphatic cyst caused by the pelvic tumor postoperative operation is effectively enhanced, the diameter of the cyst can be substantially reduced, the pain of the patient can be effectively alleviated, the cure rate can be up to 93%, and the Jindan attached-extension compound is the pure traditional Chinese medicine preparation, and has characteristics of no toxic-side effect, difficult recurrence after the cure, and no side effect after the treatment. The reference is provided for treating the lymphatic cyst caused by the pelvic tumor operation.

Description

Technical Field

[0001] The invention relates to the medical use of Chinese patent medicine, in particular to the use of Jindan Fuyan compound as a Chinese medicine preparation for treating lymphocele caused by pelvic tumor surgery. Background Art

[0002] Pelvic tumors mainly manifest as pelvic masses. Pelvic cancer is preventable and treatable, and the main method is surgical treatment. However, patients who have undergone surgical treatment must pay attention. Clinically, lymphatic cysts are more common after surgical treatment of gynecological malignancies. When undergoing B-ultrasound examination, the presence of lymphatic cysts can often be observed. With the continuous secretion of lymph fluid and the increase in pressure, lymphatic cysts may appear as palpable lumps on the patient's body surface. In layman's terms, there is a dead space in the peritoneum after lymph node resection, or the local gap is too large, and the returning lymph fluid or surgical exudate is accumulated in the peritoneum to form a cyst problem. This is what is clinically referred to as pelvic lymphatic cysts. Pelvic lymphatic cysts are a common complication after lymph node dissection for pelvic malignancies. It usually occurs 5 to 8 days after surgery, and at the latest 23 days after surgery. In the early stage of lymphatic cyst, there will be mild lower abdominal distension and pain. If infection occurs in the later stage, there will be obvious fever, increased lower abdominal pain, obvious local tenderness and other symptoms or signs. In addition, the cyst is relatively large in diameter and is easy to rupture, causing bleeding, which can even be life-threatening in severe cases. Clinically, puncture and drainage is a more commonly used method, but this method is tantamount to adding fuel to the fire and cannot cure the disease. Moreover, after puncture and drainage, a sclerosant is injected to cause a sterile inflammatory reaction in the cyst wall, which in turn causes fibrosis and atrophy of the cyst wall. However, it is necessary to be vigilant against serious complications caused by injection into surrounding tissues. Therefore, reducing the pain of patients and finding a drug suitable for the treatment of lymphatic cysts caused by pelvic tumor surgery has become an urgent problem to be solved.

[0003] There is currently no specific method for the treatment of pelvic lymphocele, but clinical studies have shown that traditional Chinese medicine has a good therapeutic effect in the treatment of this disease. Traditional Chinese medicine has always played a unique role in the treatment of pelvic lymphocele. Currently, the main clinical methods include external application of Chinese medicine, oral and external application of Chinese medicine, and enema of Chinese medicine. Compared with Western medicine, traditional Chinese medicine has been widely recognized in the clinical practice of treating pelvic lymphocele. Traditional Chinese medicine treatment measures are supplemented by the principles of promoting blood circulation and removing blood stasis, eliminating symptoms and dispersing nodules, clearing away heat and dampness, and are non-invasive and safe.

[0004] This study investigated the clinical value of Jindan Fuyan granules for oral administration in the treatment of pelvic lymphatic cysts after cervical cancer surgery. The raw materials of peony bark and honeysuckle were first recorded in Shennong's Herbal Classic and have the effects of promoting blood circulation and removing blood stasis, clearing away heat and detoxifying. Daxietong has the effects of reducing swelling, dispersing nodules, and relieving inflammation and pain. Jindan Fuyan granules can replenish blood, promote blood circulation, and relieve pain. They have the effect of removing heat without hurting the body. They can clear away heat and dampness without leaving stasis, promote blood circulation and remove blood stasis without hurting blood, clear away heat and detoxify, and promote dampness and heat. They have a good therapeutic effect on pelvic lymphatic cysts. Jindan Fuyan granules can also prevent and treat postoperative lymphedema of gynecological malignancies by inhibiting inflammatory response, reducing blood viscosity, improving blood rheology, accelerating the establishment of lymphatic circulation collaterals, and promoting the centripetal return of lymph fluid. Summary of the invention

[0005] The purpose of the present invention is to provide a new medical application of Jindan Fuyan compound.

[0006] In order to solve the above technical problems, the present invention provides the use of Jindan Fuyan compound as a traditional Chinese medicine preparation for treating lymphocele caused by pelvic tumor surgery.

[0007] A Chinese medicine for treating lymphedema caused by pelvic tumor surgery, comprising a medicine made of the following raw materials in weight ratio: 260 parts of peony bark, 260 parts of honeysuckle, 200 parts of patrinia herb, 200 parts of sedum seu ... Peony bark and honeysuckle were first recorded in Shennong's Herbal Classic. They have the effects of promoting blood circulation, removing blood stasis, clearing away heat and detoxifying. Glauber's salt, Baijiang, and Daxietong have the effects of reducing swelling, dispersing nodules, and relieving inflammation and pain. Jindan Fuyan Granules contain Xianfang Huomingyin in the prescription, and Hongteng Baijiang Decoction mainly has the effects of reducing swelling, relieving pain, controlling inflammation, promoting tissue repair, reducing capillary permeability, promoting the absorption of exudates, improving blood rheology and microcirculation disorders, improving tissue hypoxia, promoting metabolism, accelerating the establishment of lymphatic lateral circulation, enhancing the absorption capacity of the chest and peritoneum, and promoting the centripetal return of lymph fluid. The above shows that Jindan Granules can effectively discharge the lymph fluid that has returned and accumulated in the abdominal cavity after surgery and relieve the pressure, so that the cyst cavity is closed, thereby improving the cysts that appear after gynecological surgery.

[0008] The present invention is proved by the effect of actual cases, and the result shows that 1 to 3 courses of treatment of Jindan granules can effectively reduce lymphocele caused by surgery for treating pelvic tumors.

[0009] The inventors have found through research that Jindan Fuyan compound has a good effect in treating lymphocele caused by pelvic tumor surgery, and thus invented the use of Jindan Fuyan compound as a traditional Chinese medicine preparation for treating lymphocele caused by pelvic tumor surgery.

[0010] The present invention has been further verified by the following cases. DETAILED DESCRIPTION

[0011] The present invention will be further described in detail below in conjunction with cases.

[0012] Case 1

[0013] Patient 1, female, 56 years old. Clinical diagnosis: Endometrial malignant tumor. After surgery, an ultrasound examination in the hospital revealed: uterine absence (surgical resection), one size of about 64x30mm on the left side, the second size of about 40X28mm, one size of about 57X36mm on the right side, and the second size of about 19X18mm on the left side, which can be seen beside the bilateral iliac vessels. After a course of treatment with Jindan Fuyan Granules under the guidance of the doctor. After 28 days of reexamination, it was found that one lymph cyst was reduced, and one size of about 75x39mm on the left side, the second size of about 45X33mm, and one size of about 63X44mm on the right side. Repurchased 2 boxes of Jindan Fuyan Granules. After 20 days of reexamination, it was found that one lymph cyst was reduced again and the left and right lymph cysts were significantly reduced. The left size of about 39x31mm and the right size of about 57X49mm can be seen beside the bilateral iliac vessels.

[0014] Case 2

[0015] Patient 2, female, 52 years old. One year ago, she underwent total hysterectomy, bilateral adnexectomy, appendectomy, pelvic and para-aortic lymph node dissection under general anesthesia. Postoperative diagnosis: high-grade ovarian serous carcinoma stage IIB (bilateral ovaries, sigmoid colon mesentery). After 34 days of intravenous chemotherapy, examination revealed a lymphatic cyst in front of the iliac vessels in the right pelvis, measuring approximately 5.54x3.74 cm, 1.89x1.33 cm. After that, she took a course of Jindan Fuyan granules, and 18 days later, she went to the hospital for a reexamination of a lymphatic cyst in front of the iliac vessels in the right pelvis, measuring approximately 2.09x1.19 cm. The patient took another course of Jindan granules. After 20 days, the ultrasound description of the reexamination: the uterus and bilateral ovaries were not displayed. No obvious mass-like echo was found in the pelvic cavity. No obvious effusion was found in the pelvic cavity, and the lymphatic cyst completely disappeared and was cured.

[0016] Case 3

[0017] Patient 3, female, 34 years old. She underwent cervical cancer surgery and was examined in a local hospital (Jingyang County Hospital) one month later. B-ultrasound showed a cyst mass of 5.2×2.3 cm in front of the iliac vessels on one side, accompanied by pain and discomfort. One month later, she was reexamined in another hospital and took 4 boxes of Jindan Fuyan Granules under the guidance of the doctor. After taking it, she felt that the pain was relieved. 70 days later, the B-ultrasound showed that the lymphatic cyst was 2.4×1.4 cm on the left and 2.0×1.2 cm on the right, and the cyst was reduced.

[0018] Case 4

[0019] Patient 4, female, 58 years old. After a total hysterectomy, she was examined in a hospital in Hebei Province. The ultrasound diagnosis report showed a fluid mass beside the right iliac vessels (considered a lymphocele), and the right iliac vessels were 3.46*2.76*1.98 cm, and the depth of pelvic effusion was about 2.71 cm. After taking 3 boxes of Jindan Fuyan Granules on the doctor's advice, she took 7 boxes again on the 45th day. After two courses of treatment, she went to a hospital in Hebei Province for a reexamination 44 days later. The right lymphocele and pelvic effusion disappeared and healed.

[0020] Case 5

[0021] Patient 5, female, 73 years old. Underwent surgery for cervical cancer. Description of the examination results five months later: Absent uterus (already removed), anechoic nodules were seen beside the bilateral iliac vessels, about 23mm*11mm in size (left), 28mm*11mm (right), with clear boundaries; no obvious abnormal mass echo was found in the rest of the pelvic cavity, and no obvious abnormal blood flow signal was found on CDFI. Under the guidance of the doctor, she began to take Jindan Fuyan Granules for one course of treatment, and repurchased 8 boxes 9 days later. The results of the examination at the hospital three months later were: Absent uterus (already removed), vaginal stump was OK, anechoic nodules were seen beside the bilateral iliac vessels, about 18mm*8mm in size (left), 29mm*13mm (right), with clear boundaries; no obvious abnormal mass echo was found in the rest of the pelvic cavity, and no obvious abnormal blood flow signal was found on CDFI. Lymphoceles beside the bilateral iliac vessels (the left side was slightly smaller than the front).

[0022] Case 6

[0023] Patient 6, female, 32 years old. She had a hysterectomy. One month later, color Doppler ultrasound examination revealed a 26*20mm cyst on the right side of the adnex and a 27*21mm cyst on the left side. She bought four boxes of Jindan and one box of aid on the doctor's advice. One month after taking it, color Doppler ultrasound examination showed no obvious abnormality in the pelvic cavity and the cyst had completely disappeared.

Claims

1. Application of Jindan Fuyan compound in the treatment of lymphocele caused by pelvic tumor surgery.

2. A use as claimed in claim 1, Features: The medicine is taken with boiled water, less than 15g each time, and no more than 45g per day.

3. A use as claimed in claim 2, Features: The medicine is taken with boiled water, 15g each time, three times a day, with an interval of more than 6 hours between two consecutive doses.

4. A use as claimed in claim 3, Features: One course of treatment is taking it three times a day for 24 consecutive days.