Gum protecting toothpaste and preparation method thereof, and gum protecting method

Abstract

The present application relates to the field of oral care, and to a gum protection toothpaste and a preparation method thereof, and a gum protection method. The gum protection toothpaste comprises: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers are included along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to the toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate, and a second carrier acceptable to the toothpaste. The first paste comprises a cationic antibacterial agent; the second paste comprises an anionic foaming agent and sodium azulene sulfonate. The cationic antibacterial agent and the anionic surfactant can be mixed and used immediately to release activity; sodium azulene sulfonate and the cationic antibacterial agent work together to achieve the effects of antibacterial and anti-inflammatory effects; and truly effective gum protection is achieved.

Description

Technical Field

[0001] The present application relates to the field of oral care, and in particular, to a gum protecting toothpaste and a preparation method thereof, and a gum protecting method. Background Art

[0002] The active ingredients used in existing gum protection toothpastes mainly include: biguanide antibacterial agents (such as chlorhexidine), organic acids (such as tranexamic acid), phenolic antibacterial agents (such as eugenol, thymol, paeonol), plant extracts (such as sodium copper chlorophyllin, borneol), fluoride, allantoin and zinc-containing compounds.

[0003] However, these active ingredients can only produce a single antibacterial effect, and their gum protection effect is limited. Summary of the invention

[0004] The purpose of the embodiments of the present application is to provide a gum protecting toothpaste and a preparation method thereof, and a gum protecting method.

[0005] In a first aspect, the present application provides a gum protection toothpaste, comprising:

[0006] Extruding a container, a first paste, and a second paste;

[0007] The extrusion container comprises: a container body;

[0008] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one sub-chamber;

[0009] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste.

[0010] Dental plaque is a complex three-dimensional structure composed of microbial cells and extracellular polymer matrices of various genera such as Streptococcus, Lactobacillus, Actinomycetes, etc. in the oral cavity. It adheres to and colonizes on the surface of teeth. It is also called microbial plaque and dental plaque biofilm. It is the main factor causing periodontal disease. The maturation process of dental plaque biofilm forms a more complex microbial community. It is not a simple superposition of bacteria, but a group with a highly differentiated structure formed by the coordinated interaction of bacteria. The composition and diversity of changes in the microbiome determine the balance and imbalance of the human oral microecology system, and determine the occurrence and development of oral diseases.

[0011] The gradual accumulation of dental plaque will further lead to gum bleeding and gingivitis. Therefore, inhibiting dental plaque is the main means of preventing gum problems.

[0012] Cationic antibacterial agents have the advantages of broad-spectrum antibacterial activity, rapid action, small dosage and safety. They are more suitable for inhibiting dental plaque than conventional phenolic antibacterial agents.

[0013] Further research has found that while anti-bacterial and anti-inflammatory effects are needed in combination, in order to effectively inhibit dental plaque and achieve a true gum protection effect.

[0014] Further research has found that effective cleaning and stain removal can help inhibit dental plaque and protect gums.

[0015] Moreover, toothpaste, as an oral cleaning product, usually needs to use a foaming agent to generate enough foam to achieve a stain removal and cleaning effect, which is more conducive to inhibiting dental plaque. Anionic surfactants have excellent foaming effects, but when anionic surfactants and cationic antibacterial agents exist in the same paste, long carbon chain anions and cations are prone to electrostatic interactions that neutralize the antibacterial effect of the cations, resulting in reduced surface activity, while affecting the amount of foam and reducing the emulsified stain removal and cleaning effect.

[0016] The above technical scheme of the present application provides a new gum protection toothpaste that is "mixable and ready to use", wherein the first paste includes: a cationic antibacterial agent; the second paste includes an anionic foaming agent and sodium azulene sulfonate; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet; the first paste and the second paste are not pre-mixed, but are mixed by brushing when applied to the oral cavity. Since the first paste and the second paste are not pre-mixed, the anionic foaming agent in the second paste will not affect the activity of the cationic antibacterial agent in the first paste, thereby effectively ensuring the antibacterial effect. Similarly, the anionic foaming agent will not be consumed by the cationic antibacterial agent, affecting the foaming effect and the cleaning effect. At the same time, the sodium azulene sulfonate in the second paste has not been pre-mixed with the cationic antibacterial agent, nor will it affect the activity of the cationic antibacterial agent. When the first paste and the second paste are mixed in the oral cavity, the sodium azulene sulfonate can play an anti-inflammatory role, and the cationic antibacterial agent plays an antibacterial role, thereby achieving effective gum protection from the two aspects of antibacterial and anti-inflammatory, and since the anionic foaming agent has a good foaming effect and a good cleaning function, the entire gum protection toothpaste has a better taste.

[0017] That is, the above technical scheme of the present application creatively proposes a "mix-and-use" gum protection toothpaste, which effectively ensures the activity of the cationic antibacterial agent and the foaming effect of the anionic surfactant in the toothpaste, so that they can give full play to their respective roles during use and release their activity to the maximum extent; at the same time, the anionic surfactant is compounded with sodium azulene sulfonate, and is respectively set in two pastes with the cationic antibacterial agent, so as to exert the antibacterial and anti-inflammatory effects at the same time; thus, truly effective gum protection is achieved.

[0018] In other embodiments of the present application, in the second paste, the amount of sodium azulene sulfonate added is 0.01% to 0.5% by mass.

[0019] In other embodiments of the present application, in the second paste, the amount of anionic foaming agent added is 1.0% to 4.0% by mass.

[0020] In other embodiments of the present application, in the first paste, the amount of the cationic antibacterial agent added is 0.05% to 0.5% by mass.

[0021] In other embodiments of the present application, the molar ratio of the anionic foaming agent to the cationic antibacterial agent is 1:(0.5~2).

[0022] In other embodiments of the present application, the molar ratio of sodium azulene sulfonate to the cationic antibacterial agent is (1-4): (1-2).

[0023] In other embodiments of the present application, the cationic antibacterial agent includes at least one of chlorhexidine, cetylpyridinium chloride, olaflur, benzalkonium chloride, and benzethonium chloride.

[0024] In other embodiments of the present application, the anionic foaming agent includes: one or more of sodium lauryl sulfate, sodium lauryl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl glycinate or sodium cocoyl glutamate.

[0025] In other embodiments of the present application, the first paste further includes: a soluble zinc salt; in terms of mass percentage, the added amount of the soluble zinc salt is 0.1% to 0.8%.

[0026] In other embodiments of the present application, the soluble zinc salt includes at least one of zinc citrate, zinc lactate, zinc gluconate, zinc chloride or zinc sulfate.

[0027] In other embodiments of the present application, the second paste further comprises: a Chinese herbal antibacterial agent;

[0028] Optionally, the Chinese herbal antibacterial agent includes at least one of paeonol, eugenol or thymol.

[0029] In other embodiments of the present application, in the second paste, the amount of the Chinese herbal antibacterial agent added is 0.01% to 0.4% by mass.

[0030] In other embodiments of the present application, the first carrier includes: a solvent, a humectant, a thickener, an appearance improver, and a friction agent;

[0031] Optionally, the solvent includes: water;

[0032] Optionally, the moisturizer includes: at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol;

[0033] Optionally, the thickener includes: at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose;

[0034] Optionally, the appearance improver includes: titanium dioxide;

[0035] Optionally, the friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

[0036] In other embodiments of the present application, the first paste includes, by mass percentage: 0.05%-0.5% cationic antibacterial agent, 0.1%-0.8% soluble zinc salt; 5%-30% solvent; 35%-60% moisturizer, 0.1%-13% thickener, 0.2%-0.8% appearance improver, and 5%-22% abrasive.

[0037] In other embodiments of the present application, the second carrier includes: a solvent, a humectant, a thickener, an appearance improver, and a friction agent;

[0038] Optionally, the solvent includes: water;

[0039] Optionally, the moisturizer includes: at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol;

[0040] Optionally, the thickener includes: at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose;

[0041] Optionally, the appearance improver includes: titanium dioxide;

[0042] Optionally, the friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

[0043] In other embodiments of the present application, the second paste includes, by mass percentage: 0.01%~0.5% sodium azulene sulfonate, 1.0%~4.0% anionic foaming agent; 0.01%~0.4% Chinese herbal antibacterial agent; 5%-30% solvent; 30%-60% moisturizer, 0.1%-13% thickener, 0.2%-0.8% appearance improver, and 5%-22% abrasive.

[0044] In other embodiments of the present application, the extrusion container further comprises: a cover plate, a transmission extrusion structure and a partition plate;

[0045] The partition is arranged in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body;

[0046] The cover plate is detachably connected to the tail of the container body through a connecting structure to perform sealing;

[0047] The transmission extrusion structure is arranged in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

[0048] In other embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0049] In other embodiments of the present application, a gum protection toothpaste includes: a base;

[0050] The base comprises: a base body;

[0051] A driving component is disposed in the base body;

[0052] The transmission structure is arranged in the base body and connected to the driving component; the transmission structure is provided with a docking component, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base is assembled with the extrusion container; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste;

[0053] A control module is disposed in the base body and is electrically connected to the driving component;

[0054] The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

[0055] In other embodiments of the present application, the transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

[0056] In a second aspect, the present application provides a method for preparing a gum protecting toothpaste.

[0057] Gum care toothpaste includes:

[0058] Extruding a container, a first paste, and a second paste;

[0059] The extrusion container comprises: a container body;

[0060] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste;

[0061] The preparation method comprises:

[0062] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0063] In other embodiments of the present application, in the second paste, the amount of sodium azulene sulfonate added is 0.01% to 0.5% by mass.

[0064] In a third aspect, the present application provides a method for protecting gums.

[0065] Provided is a gum protection toothpaste, comprising:

[0066] Extruding a container, a first paste, and a second paste;

[0067] The extrusion container comprises: a container body;

[0068] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste;

[0069] Methods include:

[0070] When the transmission extrusion structure squeezes the first paste and the second paste in the cavity out of the outlet, the first paste and the second paste are applied to the oral care appliance; and the oral care appliance is used to clean the oral cavity.

[0071] In a fourth aspect, the present application provides a gum protection toothpaste, comprising:

[0072] Extruding a container, a first paste, and a second paste;

[0073] The extrusion container comprises: a container body;

[0074] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers;

[0075] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste.

[0076] In a fifth aspect, the present application provides a gum protection toothpaste, comprising:

[0077] Extruding a container, a first paste, and a second paste;

[0078] The extrusion container comprises: a container body;

[0079] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers;

[0080] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent and a second carrier acceptable to toothpaste.

[0081] The above technical solution can effectively avoid the interaction between the cationic antibacterial agent and the anionic foaming agent in one formula by setting them separately, reduce the antibacterial activity of the cationic antibacterial agent, and reduce the foaming effect of the anionic foaming agent; it can play an effective gum protection effect.

[0082] In a sixth aspect, the present application provides a gum protection toothpaste, comprising:

[0083] Extruding a container, a first paste, and a second paste;

[0084] The extrusion container comprises: a container body;

[0085] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers;

[0086] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: sodium azulene sulfonate and a second carrier acceptable to toothpaste.

[0087] The above technical solution can effectively avoid the interaction between the cationic antibacterial agent and sodium azulene sulfonate in one formula by setting the cationic antibacterial agent and sodium azulene sulfonate separately, reduce the antibacterial activity of the cationic antibacterial agent, and reduce the anti-inflammatory effect of sodium azulene sulfonate; it can play an effective gum protection effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0088] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0089] Figure 1 This is a schematic structural diagram of a gum-protecting toothpaste according to an embodiment of the present application;

[0090] Figure 2 This is a schematic structural diagram of an extrusion container according to an embodiment of the present application;

[0091] Figure 3 A structural schematic diagram of a base from one perspective of an embodiment of the present application;

[0092] Figure 4 This is a structural schematic diagram of the base from another perspective of the implementation scheme of the present application.

[0093] Icons: 1-gum-protecting toothpaste; 10-extrusion container; 100-container body; 200-cover plate; 130-partition plate; 110-chamber; 120-outlet; 111-subchamber; 300-connecting structure; 410-transmission member; 420-piston; 11-base; 12-base body; 13-driving member; 14-transmission structure; 15-docking member; 16-extension; 141-bracket; 142-transmission member; 800-cap body; 1500-snap assembly. DETAILED DESCRIPTION

[0094] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0095] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0096] Some embodiments of the present application provide a gum protection toothpaste, comprising: an extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in a sub-chamber; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate, and a second carrier acceptable to toothpaste.

[0097] The above technical scheme of the present application provides a new gum protection toothpaste that is "mixable and ready to use", wherein the first paste includes: a cationic antibacterial agent; the second paste includes an anionic foaming agent and sodium azulene sulfonate; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet; the first paste and the second paste are not pre-mixed, but are mixed by brushing when applied to the oral cavity. Since the first paste and the second paste are not pre-mixed, the anionic foaming agent in the second paste will not affect the activity of the cationic antibacterial agent in the first paste, thereby effectively ensuring the antibacterial effect. Similarly, the anionic foaming agent will not be consumed by the cationic antibacterial agent, affecting the foaming effect and the cleaning effect. At the same time, the sodium azulene sulfonate in the second paste has not been pre-mixed with the cationic antibacterial agent, nor will it affect the activity of the cationic antibacterial agent. When the first paste and the second paste are mixed in the oral cavity, the sodium azulene sulfonate can play an anti-inflammatory role, and the cationic antibacterial agent plays an antibacterial role, thereby achieving effective gum protection from the two aspects of antibacterial and anti-inflammatory, and since the anionic foaming agent has a good foaming effect and a good cleaning function, the entire gum protection toothpaste has a better taste.

[0098] Reference Figure 1~Figure 4 Some embodiments of the present application provide a gum protection toothpaste 1, comprising:

[0099] Extrusion container 10, first paste (not shown), second paste (not shown);

[0100] The extrusion container 10 comprises: a container body 100, a cover plate 200, a transmission extrusion structure and a partition plate 130;

[0101] The container body 100 is provided with a chamber 110, and an outlet 120 is provided on the container body 100, and the outlet 120 is communicated with the chamber 110; a partition 130 is provided in the chamber 110, and the partition 130 is used to divide the chamber 110 into at least two sub-chambers 111 along the extension direction of the container body 100, and the sub-chambers 111 are communicated with the outlet 120; the first paste and the second paste are respectively contained in one sub-chamber 111;

[0102] The cover plate 200 is detachably connected to the rear portion of the container body 100 through the connection structure 300 for sealing;

[0103] The transmission extrusion structure is disposed in the container body 100 and is movably connected to the cover plate 200. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber 110 from the outlet 120.

[0104] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste.

[0105] Cationic antibacterial agents have the advantages of broad-spectrum antibacterial, rapid action, small dosage, and safety. They are more widely applicable than conventional phenolic antibacterial agents (phenolic antibacterial agents have a strong characteristic taste). Toothpaste, as an oral cleaning product, usually requires the use of a foaming agent to produce enough foam to achieve a cleaning effect. Anionic surfactants have excellent foaming effects, but when anionic surfactants and cationic antibacterial agents exist in the same paste, electrostatic interactions between long carbon chain anions and cations are likely to neutralize the antibacterial effect of the cations, resulting in reduced surface activity, while affecting the amount of foam and reducing the emulsified stain removal cleaning effect.

[0106] The above technical scheme of the present application provides a new gum protection toothpaste that is "mixable and ready to use", wherein the first paste includes: a cationic antibacterial agent; the second paste includes an anionic foaming agent and sodium azulene sulfonate; during the use stage, the first paste and the second paste are squeezed out from the toothpaste outlet through a transmission extrusion structure; the first paste and the second paste are not pre-mixed, but are mixed by brushing when applied to the oral cavity. Since the first paste and the second paste are not pre-mixed, the anionic foaming agent in the second paste will not affect the activity of the cationic antibacterial agent in the first paste, thereby effectively ensuring the antibacterial effect; and similarly, the anionic foaming agent will not be consumed by the cationic antibacterial agent, affecting the foaming effect and the cleaning effect; at the same time, the sodium azulene sulfonate in the second paste has not been pre-mixed with the cationic antibacterial agent, nor will it affect the activity of the cationic antibacterial agent; when the first paste and the second paste are mixed in the oral cavity, the sodium azulene sulfonate can play an anti-inflammatory role, and the cationic antibacterial agent plays an antibacterial role, thereby achieving effective gum protection from both antibacterial and anti-inflammatory aspects, and since the anionic foaming agent has good foaming effect and good cleaning function, the entire gum protection toothpaste has a better taste.

[0107] That is, the above technical scheme of the present application creatively proposes a "mix-and-use" gum protection toothpaste, which effectively ensures the activity of the cationic antibacterial agent and the foaming effect of the anionic surfactant in the toothpaste, so that they can give full play to their respective roles during use and release their activity to the maximum extent; at the same time, the anionic surfactant is compounded with sodium azulene sulfonate and respectively set in two pastes with the cationic antibacterial agent, thereby achieving the antibacterial and anti-inflammatory effects at the same time, and realizing truly effective gum protection.

[0108] Furthermore, in the above technical solution, the first paste and the second paste in the chamber 110 are sealed by connecting the cover plate 200 to the tail of the extrusion container 10. By arranging a transmission extrusion structure for extruding the first paste and the second paste in the container body 100, relying on the connection between the cover plate 200 and the transmission extrusion structure, the cover plate 200 can play a role in positioning and supporting the transmission extrusion structure in the process of extruding the material from the outlet, so that the transmission extrusion structure can extrude the first paste and the second paste from the outlet more stably and efficiently. The sealing effect of the cover plate 200 can improve the problem of leakage of the first paste and the second paste from the chamber 110 when the transmission extrusion structure extrude the first paste and the second paste, reduce the risk of failure of the extrusion container 10, and improve the working efficiency of the extrusion container 10 in extruding the first paste and the second paste.

[0109] Furthermore, in the above technical solution, the first paste and the second paste are squeezed out from the outlet of the chamber 110 to form a complete and shaped paste (the first paste and the second paste are in contact and connected together, but can be clearly distinguished); during the use stage, it can ensure that the user applies the first paste and the second paste to the oral cavity at the same time, and it is more conducive to the first paste and the second paste to be evenly mixed in the oral cavity; the activity of the cationic antibacterial agent in the toothpaste and the foaming effect of the anionic surfactant are effectively guaranteed, so that they interact with each other and release their activity during use; at the same time, the anionic surfactant is compounded with sodium azulene sulfonate, and is respectively arranged in the two pastes with the cationic antibacterial agent, so as to achieve the antibacterial and anti-inflammatory effects; and truly effective gum protection is achieved.

[0110] Furthermore, in the above technical solution, the first paste and the second paste are "mixed and used immediately", which is gentler, more suitable for the oral environment, and more conducive to protecting the oral mucosa. Assuming a scenario, only a single tube of ordinary toothpaste containing anionic foaming agent is used, and a cationic antibacterial agent (such as a solution) is added to the ordinary toothpaste during the use stage. If the amount of cationic antibacterial agent added is not well controlled, it will cause very large irritation, which is not conducive to the oral mucosa or the taste is particularly bad, and it also makes it very troublesome to use, and the actual application value is greatly reduced; once again, assuming that in another scenario, two active substances (such as sodium azulene sulfonate and cationic antibacterial agent) are directly used in the oral cavity, which will inevitably lead to very large irritation, which is very unfavorable to the oral mucosa; or the taste is particularly bad, and lacks decontamination effect; it also makes it very troublesome to use, greatly reducing the actual application value.

[0111] Further optionally, in some embodiments of the present application, the sub-chambers 111 are provided in two, and the first paste and the second paste are each contained in one sub-chamber 111 .

[0112] In other optional embodiments of the present application, the above-mentioned sub-chambers 111 can be optionally set to three, four or five, etc., but the first paste and the second paste are always located in two independent sub-chambers 111; the remaining sub-chambers 111 can be set according to actual needs; illustratively, other sub-chambers 111 can accommodate other pastes; or other non-paste materials (such as water, etc.); or blank settings (for example, they can be left empty for personalized use by users, etc.).

[0113] Furthermore, in some embodiments of the present application, in the second paste, the amount of sodium azulene sulfonate added is 0.01% to 0.5% by mass.

[0114] In the above technical solution, by setting the addition amount of sodium azulene sulfonate in the second paste to 0.01%~0.5%, it can be beneficial to improve the anti-inflammatory effect, thereby further helping to improve the gum protection effect.

[0115] Illustratively, in some embodiments of the present application, in the second paste, the amount of sodium azulene sulfonate added is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.45%, 0.5% or a range between any two of the foregoing values, measured in mass percentage.

[0116] In some embodiments of the present application, the molar ratio of sodium azulene sulfonate to the cationic antibacterial agent is set to (1-4): (1-2).

[0117] In the above technical solution, the molar ratio of sodium azulene sulfonate to the cationic antibacterial agent is set to (1-4): (1-2), which is beneficial to the antibacterial and anti-inflammatory effects of the toothpaste.

[0118] Illustratively, in some embodiments of the present application, the molar ratio of sodium azulene sulfonate to the cationic antibacterial agent is 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9, 1:2, 1.1:1, 1.2:1.3, 1.5:1.3, 1.8:1.4, 2:1.5, 2.5:1.6, 3:1.7, 3.2:1.8, 3.8:1.9, 4:2 or a range between any two of the foregoing values.

[0119] Furthermore, in some embodiments of the present application, in the second paste, the amount of anionic foaming agent added is 1.0% to 4.0% by mass.

[0120] In the above technical solution, by adding the anionic foaming agent in the second paste in an amount of 1.0% to 4.0%, the foaming effect of the toothpaste can be further improved, which is beneficial to the stain removal and cleaning effect, and further beneficial to improving the gum protection effect.

[0121] Illustratively, in some embodiments of the present application, in the second paste, the amount of anionic foaming agent added is 1.0%, 1.2%, 1.5%, 2.0%, 2.1%, 2.2%, 2.5%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8%, 3.9%, 4.0% or a range between any two of the foregoing values, measured in mass percentage.

[0122] Furthermore, in some embodiments of the present application, the amount of the cationic antibacterial agent added to the first paste is 0.05% to 0.5% by mass.

[0123] In the above technical solution, by adding the cationic antibacterial agent into the first paste, the addition amount is 0.05%~0.5%, which is further beneficial to improve the antibacterial effect, thereby helping to further improve the gum protection effect.

[0124] Illustratively, in some embodiments of the present application, in the first paste, the amount of cationic antibacterial agent added is 0.05%, 0.06%, 0.07%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.22%, 0.25%, 0.28%, 0.3%, 0.32%, 0.35%, 0.4%, 0.45%, 0.5% or a range between any two of the foregoing values, measured in mass percentage.

[0125] Furthermore, in some embodiments of the present application, the molar ratio of the anionic foaming agent to the cationic antibacterial agent is 1:(0.5~2).

[0126] In the above technical solution, by setting the molar ratio of the anionic foaming agent to the cationic antibacterial agent to 1: (0.5-2), it is beneficial to further improve the antibacterial effect and foaming effect of the toothpaste.

[0127] Illustratively, in some embodiments of the present application, the molar ratio of the anionic foaming agent to the cationic antibacterial agent is 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9, 1:2 or a range between any two of the foregoing values.

[0128] Furthermore, in some embodiments of the present application, the cationic antibacterial agent includes at least one of chlorhexidine, cetylpyridinium chloride, olaflur, benzalkonium chloride, and benzethonium chloride.

[0129] Illustratively, in some embodiments of the present application, the cationic antibacterial agent is selected from: any one of chlorhexidine, cetylpyridinium chloride, olaflu, benzalkonium chloride or benzethonium chloride; or in some embodiments of the present application, the above-mentioned cationic antibacterial agents are selected from: a mixture of chlorhexidine and cetylpyridinium chloride; or a mixture of olaflu, benzalkonium chloride and benzethonium chloride; or a mixture of chlorhexidine, cetylpyridinium chloride, olaflu, benzalkonium chloride and benzethonium chloride; the raw materials in each mixture can be selected and mixed in any proportion.

[0130] Furthermore, in some embodiments of the present application, the anionic foaming agent includes: one or more of sodium lauryl sulfate, sodium lauryl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl glycinate or sodium cocoyl glutamate.

[0131] Anionic foaming agents react easily with cationic antibacterial agents, resulting in the inactivation of cationic antibacterial agents in the paste during storage; in addition, the consumption of anionic foaming agents will also lead to a decrease in the amount of foam during brushing, thereby weakening the ability to remove dirt in the oral cavity.

[0132] In the above technical solution, since the anionic foaming agent is arranged in the second paste and is physically isolated from the cationic antibacterial agent in the first paste, the loss of the activity of the cationic antibacterial agent by the anionic foaming agent is avoided. At the same time, the use of anionic foaming agent in the second paste can effectively improve the overall foaming effect of the toothpaste, improve the decontamination ability, and enhance the taste of use.

[0133] For example, in some embodiments of the present application, the anionic foaming agent is selected from any one of sodium lauryl sulfate, sodium lauryl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl glycinate or sodium cocoyl glutamate. Or in some embodiments of the present application, the above anionic foaming agent is selected from a mixture of sodium lauryl sulfate and sodium lauryl sarcosinate; or in some embodiments of the present application, the above anionic foaming agent is selected from a mixture of sodium cocoyl glycinate and sodium cocoyl glutamate; each raw material in each of the above mixtures can be selected and mixed in any proportion.

[0134] Furthermore, in some embodiments of the present application, the first paste further includes: a soluble zinc salt; in terms of mass percentage, the added amount of the soluble zinc salt is 0.1% to 0.8%.

[0135] In the above technical solution, the antibacterial effect can be further improved by adding a soluble zinc salt to the first paste.

[0136] Soluble zinc salts have a clear effect of inhibiting dental plaque and alleviating gum problems. The current mainstream antibacterial mechanism is the zinc ion dissolution antibacterial theory, in which dissolved zinc ions come into contact with bacteria to produce antibacterial effects. Zinc ion dissolution antibacterial can destroy cell membrane function, denature bacterial proteins or enzymes, and zinc ions entering bacterial cells may also bind to nucleic acids, destroying the cell's ability to divide and reproduce, thereby achieving the purpose of antibacterial and antibacterial. Although the instantaneous antibacterial effect of zinc salts is not as good as that of cationic antibacterial agents, its strong retention greatly enhances the long-term antibacterial effect of the product.

[0137] In the above technical solution, the amount of soluble zinc salt added to the first paste is 0.1%~0.8%; within the above range, the oral zinc concentration after brushing can be increased, and the retention time of zinc ions can be increased; it will not cause changes in the plaque flora, the inhibitory effect of plaque will not be weakened, and it will not cause plaque resistance.

[0138] Illustratively, in some embodiments of the present application, the first paste further includes: a soluble zinc salt; in terms of mass percentage, the amount of the soluble zinc salt added is 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.22%, 0.25%, 0.28%, 0.3%, 0.32%, 0.35%, 0.38%, 0.4%, 0.42%, 0.45%, 0.48%, 0.5%, 0.52%, 0.55%, 0.58%, 0.6%, 0.62%, 0.65%, 0.68%, 0.7%, 0.72%, 0.75%, 0.78%, 0.8% or a range between any two of the foregoing values.

[0139] Furthermore, in some embodiments of the present application, the soluble zinc salt includes at least one of zinc citrate, zinc lactate, zinc gluconate, zinc chloride or zinc sulfate.

[0140] For example, in some embodiments of the present application, the above-mentioned soluble zinc salt is selected from any one of zinc citrate, zinc lactate, zinc gluconate, zinc chloride or zinc sulfate; or in some embodiments of the present application, the above-mentioned soluble zinc salt is selected from a mixture of zinc citrate and zinc lactate; or in some embodiments of the present application, the above-mentioned soluble zinc salt is selected from a mixture of zinc gluconate, zinc chloride and zinc sulfate; the raw materials in the above-mentioned mixtures can be mixed in any proportion,

[0141] Furthermore, in some embodiments of the present application, the second paste further comprises: a Chinese herbal antibacterial agent;

[0142] Optionally, the Chinese herbal antibacterial agent includes at least one of paeonol, eugenol or thymol.

[0143] For example, in some embodiments of the present application, the above-mentioned Chinese herbal antibacterial agent is selected from any one of paeonol, eugenol or thymol. Or in some embodiments of the present application, the above-mentioned Chinese herbal antibacterial agent is selected from a mixture of paeonol and eugenol, and the raw materials in the mixture can be mixed in any proportion.

[0144] Furthermore, in some embodiments of the present application, in the second paste, the amount of the Chinese herbal antibacterial agent added is 0.01% to 0.4% by mass.

[0145] In the above technical solution, by setting the addition amount of the Chinese herbal antibacterial agent in the second paste to 0.01%~0.4%, the gum protection effect of the toothpaste can be effectively improved.

[0146] Illustratively, in some embodiments of the present application, in the second paste, the amount of Chinese herbal antibacterial agent added is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.38%, 0.4% or a range between any two of the foregoing values, measured in mass percentage.

[0147] Furthermore, in some embodiments of the present application, the first carrier includes: a solvent, a humectant, a thickener, an appearance improver, and a friction agent.

[0148] Furthermore, in some embodiments of the present application, the solvent includes: water.

[0149] Furthermore, in some embodiments of the present application, the moisturizer includes at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol.

[0150] Illustratively, in some embodiments of the present application, the above-mentioned moisturizer is selected from: any one of sorbitol, polyethylene glycols, glycerin, and propylene glycol; or in some embodiments of the present application, the above-mentioned moisturizer is selected from: a mixture of sorbitol and polyethylene glycols; or in some embodiments of the present application, the above-mentioned moisturizer is selected from: a mixture of glycerin and propylene glycol; the various raw materials in the above-mentioned mixtures can be mixed in any proportion.

[0151] Optionally, the thickener includes at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose.

[0152] Illustratively, in some embodiments of the present application, the above-mentioned thickener is selected from any one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silica, carrageenan, and hydroxyethyl cellulose; or in some embodiments of the present application, the above-mentioned thickener is selected from a mixture of polyvinyl pyrrolidone and carbomer; or in some embodiments of the present application, the above-mentioned thickener is selected from a mixture of cellulose gum, thickening silica, and carrageenan; the various raw materials in the above-mentioned mixtures can be mixed in any proportion.

[0153] Optionally, the appearance improver includes: titanium dioxide.

[0154] Optionally, the friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

[0155] For example, in some embodiments of the present application, the above-mentioned friction agent includes: any one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate. Or in some embodiments of the present application, the above-mentioned friction agent includes: a mixture of friction-type silica and calcium hydrogen phosphate; or in some embodiments of the present application, the above-mentioned friction agent includes: a mixture of calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate; each raw material in the above-mentioned mixture can be mixed in any proportion.

[0156] Furthermore, in some embodiments of the present application, the first paste includes, by mass percentage: 0.05%-0.5% cationic antibacterial agent, 0.1%-0.8% soluble zinc salt; 5%-30% solvent; 35%-60% moisturizer, 0.1%-13% thickener, 0.2%-0.8% appearance improver, and 5%-22% abrasive.

[0157] Illustratively, in some embodiments of the present application, the first paste includes, by mass percentage: 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.15%, 0.2%, 0.22%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% or a range between any two of the foregoing values ​​of a cationic antibacterial agent;

[0158] 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8% or a range between any two of the foregoing soluble zinc salts;

[0159] 5%, 8%, 10%, 15%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 30% or a range between any two of the foregoing values ​​of solvent;

[0160] 35%, 36%, 37%, 38%, 39%, 40%, 45%, 50%, 55%, 60% or a range between any two of the foregoing moisturizers;

[0161] 0.1%, 0.2%, 0.5%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 13% or a range between any two of the foregoing values ​​of thickener;

[0162] 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8% or the range between any two of the foregoing appearance improvers;

[0163] 5%, 6%, 7%, 8%, 9%, 10%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22% or a range between any two of the foregoing values ​​of abrasive.

[0164] Furthermore, in some embodiments of the present application, the second carrier includes: a solvent, a humectant, a thickener, an appearance improver, and a friction agent.

[0165] Optionally, the solvent includes: water;

[0166] Optionally, the moisturizer includes: at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol;

[0167] Optionally, the thickener includes: at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose;

[0168] Optionally, the appearance improver includes: titanium dioxide;

[0169] Optionally, the friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

[0170] Furthermore, in some embodiments of the present application, the second paste includes, by mass percentage: 0.01%~0.5% sodium azulene sulfonate, 1.0%~4.0% anionic foaming agent; 0.01%~0.4% Chinese herbal antibacterial agent; 5%-30% solvent; 30%-60% moisturizer, 0.1%-13% thickener, 0.2%-0.8% appearance improver, and 5%-22% abrasive.

[0171] Illustratively, in some embodiments of the present application, the second paste includes, by mass percentage: 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.25%, 0.28%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% or a range between any two of the foregoing values ​​of sodium azulene sulfonate;

[0172] 1.0%, 1.2%, 1.5%, 1.6%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.6%, 3.8%, 4.0% or a range between any two of the foregoing anionic blowing agent;

[0173] 0.01%, 0.02%, 0.05%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.25%, 0.28%, 0.3%, 0.32%, 0.35%, 0.38%, 0.4% or a range between any two of the foregoing values ​​of Chinese herbal antibacterial agents;

[0174] 5%, 6%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30% or a range between any two of the foregoing values ​​of solvent;

[0175] 30%, 31%, 32%, 33%, 34%, 35%, 38%, 40%, 42%, 45%, 48%, 50%, 52%, 55%, 58%, 60% or a range between any two of the foregoing moisturizers;

[0176] 0.1%, 0.2%, 0.5%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13% or a range between any two of the foregoing thickeners;

[0177] 0.2%, 0.22%, 0.25%, 0.28%, 0.3%, 0.35%, 0.38%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.7%, 0.75%, 0.8% or the range between any two of the foregoing appearance improvers;

[0178] 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22% or a range between any two of the foregoing values ​​of abrasive.

[0179] Furthermore, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is connected to the transmission member, and the transmission member drives the piston forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

[0180] Please refer to Figure 2 As shown, in some embodiments of the present application, the transmission extrusion structure includes: a transmission member 410 and a piston 420, one end of the transmission member 410 is movably connected to the cover plate 200, the transmission member 410 is arranged in the chamber 110 along the extension direction of the container body 100, the piston 420 is transmission-connected to the transmission member 410, and the transmission member 410 drives the piston 420 to move forward or backward along the axial extension direction of the transmission member 410 to realize the extrusion of the material.

[0181] In this embodiment, the piston 420 can be driven forward or backward along the axial extension direction of the transmission member 410 by the forward and reverse transmission of the transmission member 410 in the transmission extrusion structure, thereby realizing automatic extrusion of the material in the chamber 110 by the piston 420.

[0182] by Figure 1~Figure 2 Taking the structure of the extrusion container 10 shown as an example, since a partition 130 is provided in the container body 100, the chamber 110 of the container body 100 is divided into two to form two independent sub-chambers 111, and each sub-chamber 111 is used to contain the first paste and the second paste. In order to realize the automatic synchronous extrusion of the toothpaste paste in the two sub-chambers 111 and achieve the purpose of mixing and using, the transmission extrusion structure in this embodiment includes two transmission members 410 and two pistons 420, and each sub-chamber 111 is respectively provided with a transmission member 410 and a piston 420, and the two transmission members 410 can rotate synchronously, thereby driving the two pistons 420 to realize synchronous forward or backward movement, and finally realizing the automatic synchronous extrusion of the toothpaste paste of different components in the two sub-chambers 111.

[0183] In some embodiments of the present application, the transmission extrusion structure may be an electric push rod, at the end of which a piston 420 is disposed, and the electric push rod pushes the piston 420 forward or backward to achieve automatic extrusion of the toothpaste paste.

[0184] Further, refer to Figure 3~Figure 4 In some embodiments of the present application, the gum protection toothpaste includes: a base 11;

[0185] The base 11 includes: a base body 12;

[0186] A driving component 13 is disposed in the base body 12;

[0187] The transmission structure 14 is arranged in the base body 12 and connected to the driving component 13; the transmission structure 14 is provided with a docking component 15, and the docking component 15 is used to be fixedly connected with the transmission extrusion structure in the extrusion container 10 when the base 11 and the extrusion container 10 are assembled; the driving component 13 drives the transmission structure 14, and then drives the transmission extrusion structure fixedly connected to the docking component 15, so as to realize the extrusion of the first paste and the second paste;

[0188] The control module is disposed in the base body 12 and is electrically connected to the driving component 13;

[0189] The power supply module is disposed in the base body 12 and is electrically connected to the control module and the driving component 13 respectively.

[0190] Furthermore, in some embodiments of the present application, the transmission structure 14 includes: a bracket 141 and a transmission member 142; the transmission member 142 is arranged on the bracket 141, the output end of the driving component 13 passes through the bracket 141, and the output end of the driving component 13 is connected to the transmission member 142, and the docking component 15 is arranged on one end of the transmission member 142 away from the output end of the driving component 13.

[0191] Please refer to Figure 1~Figure 4 As shown, a switch is provided on the container body 100, and a plug-in component is provided on the container body. The switch is electrically connected to the plug-in component, and the plug-in component is used to electrically connect with a conductive component on a base mounted in cooperation with the extrusion container 10 to transmit an electrical signal.

[0192] In some embodiments of the present application, after the base and the extrusion container 10 are installed, the driving structure is docked with the transmission extrusion structure in the extrusion container 10. After the user triggers the switch, the circuit between the extrusion container 10 and the base is turned on. The control module sends a control instruction to the driving structure according to the switch signal triggered by the user. The driving structure receives the instruction and drives the transmission extrusion structure to work, and the piston is pushed forward by the rotation of the transmission member 410, thereby realizing the automatic and synchronous extrusion of the first paste and the second paste.

[0193] In some embodiments of the present application, the gum protection toothpaste 1 further includes: a cap body 800 , and the cap body 800 is connected to the container body 100 .

[0194] In some embodiments of the present application, a snap assembly 1500 is provided on the base body 12 , and the base body 12 is detachably connected to the extrusion container via the snap assembly 1500 .

[0195] In some embodiments of the present application, an extension portion 16 is provided on the base body 12 , a switch and a plug-in component are provided on the extension portion 16 , and the switch is provided on the extension portion 16 and on one end close to the outlet of the extrusion container.

[0196] The double-tube gum protection toothpaste provided by the above technical solution combines a cationic antibacterial agent with a zinc salt in the first paste; an anionic foaming agent with sodium azulene sulfonate in the second paste; when brushing teeth, the two tubes of toothpaste are squeezed out in equal amounts at the same time to achieve ready-to-mix and ready-to-use, avoiding premature contact between anions and cations causing the active effects to fail, achieving enhanced antibacterial and anti-inflammatory effects, and at the same time improving the foaming performance and emulsification stain removal effect of the foaming agent.

[0197] Furthermore, the above-mentioned double-tube gum protection toothpaste can further achieve synergistic enhancement of the gum protection and antibacterial effect by compounding Chinese herbal antibacterial agents such as paeonol, eugenol, thymol, etc.

[0198] In some embodiments of the present application, the above-mentioned Chinese herbal antibacterial agent can be placed in any paste, for example, compounded in the first paste or the second paste.

[0199] Some embodiments of the present application provide a method for preparing a gum protection toothpaste:

[0200] Extruding a container, a first paste, and a second paste;

[0201] The extrusion container comprises: a container body;

[0202] The container body comprises at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one sub-chamber;

[0203] The first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste;

[0204] The preparation method of the toothpaste comprises:

[0205] A first paste is injected into one sub-chamber; and a second paste is injected into another sub-chamber.

[0206] In some embodiments of the present application, in the second paste, the amount of sodium azulene sulfonate added is 0.01% to 0.5% by mass.

[0207] Some embodiments of the present application provide a method for gum protection:

[0208] Provided is a gum protection toothpaste, comprising:

[0209] Extruding a container, a first paste, and a second paste;

[0210] The extrusion container comprises: a container body;

[0211] The container body includes at least two sub-chambers along the extension direction; the first paste and the second paste are each contained in one sub-chamber; the first paste includes: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste includes: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste;

[0212] This gum care method includes:

[0213] When the first paste and the second paste are squeezed out from the outlet, the first paste and the second paste are applied to the oral care appliance; and the oral care appliance is used to clean the oral cavity.

[0214] Some embodiments of the present application provide a gum protection toothpaste, comprising:

[0215] Extruding a container, a first paste, and a second paste;

[0216] The extrusion container comprises: a container body;

[0217] The container body includes at least two sub-chambers along the extension direction; the first paste and the second paste are respectively contained in a sub-chamber; the first paste includes: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste includes: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste.

[0218] The features and properties of the present application are further described in detail below in conjunction with the examples, and each raw material used in the examples can be purchased commercially;

[0219] The formula of the first paste or the second paste in each embodiment or comparative example is selected from Table 1 to Table 9; the first paste and the second paste can be prepared by the conventional toothpaste preparation process in the art. Unit in the table: mass percentage.

[0220] Table 1A1 - Cation Tube

[0221] Raw material properties raw material W% Solvents Deionized water 24.76 Moisturizer Sorbitol 38 Moisturizer PEG-8 8 Thickener Xanthan gum 0.5 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.3 Sweeteners Trichlorogalactose 0.14 Antibacterial Agents Zinc Citrate 0.4 Antibacterial Agents Cetylpyridinium chloride 0.2 Thickener Silicon dioxide (thickening type) 6 Friction agent Silicon dioxide (friction type) 20 Fragrance essence 1.2

[0222] Table 2B1 - Anion Tube

[0223] Raw material properties raw material W% Solvents Deionized water 23.96 Moisturizer Sorbitol 35 Moisturizer PEG-8 8 Thickener Xanthan gum 0.6 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.3 Sweeteners Trichlorogalactose 0.14 Foaming agent Sodium Lauryl Sulfate 3.8 Anti-inflammatory agents Sodium azulene sulfonate 0.4 Antibacterial Agents Eugenol 0.1 Thickener Silicon dioxide (thickening type) 6 Friction agent Silicon dioxide (friction type) 20 Fragrance essence 1.2

[0224] Table 3A2 - Cation Tube

[0225] Raw material properties raw material W% Solvents Deionized water 24.86 Moisturizer Sorbitol 38 Moisturizer PEG-8 8 Thickener Xanthan gum 0.5 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.3 Sweeteners Trichlorogalactose 0.14 Antibacterial Agents Zinc Citrate 0.4 Antibacterial Agents Cetylpyridinium chloride 0.1 Thickener Silicon dioxide (thickening type) 6 Friction agent Silicon dioxide (friction type) 20 Fragrance essence 1.2

[0226] Table 4B2 - Anion Tube

[0227] Raw material properties raw material W% Solvents Deionized water 24.16 Moisturizer Sorbitol 35 Moisturizer PEG-8 8 Thickener Xanthan gum 0.6 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.3 Sweeteners Trichlorogalactose 0.14 Foaming agent Sodium Lauryl Sulfate 3.8 Anti-inflammatory agents Sodium azulene sulfonate 0.2 Antibacterial Agents Eugenol 0.1 Thickener Silicon dioxide (thickening type) 6 Friction agent Silicon dioxide (friction type) 20 Fragrance essence 1.2

[0228] Table 5A3 - Cation Tube

[0229] Raw material properties raw material W% Solvents Deionized water 27.97 Moisturizer Sorbitol 26 Moisturizer glycerin 16 Thickener Carrageenan 0.4 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.4 Sweeteners Trichlorogalactose 0.13 Antibacterial Agents Zinc Citrate / Antibacterial Agents Cetylpyridinium chloride 0.5 Thickener Silicon dioxide (thickening type) 5 Friction agent Silicon dioxide (friction type) 22 Fragrance essence 1.1

[0230] Table 6B3 - Anion Tube

[0231] Raw material properties raw material W% Solvents Deionized water 27.46 Moisturizer Sorbitol 26 Moisturizer glycerin 16 Thickener Carrageenan 0.4 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.4 Sweeteners Trichlorogalactose 0.13 Foaming agent Sodium Lauryl Sulfate 1.0 Anti-inflammatory agents Sodium azulene sulfonate 0.01 Antibacterial Agents Eugenol / Thickener Silicon dioxide (thickening type) 5 Friction agent Silicon dioxide (friction type) 22 Fragrance essence 1.1

[0232] Table 7A4 - Cation Tube

[0233] Raw material properties raw material W% Solvents Deionized water 28.42 Moisturizer Sorbitol 26 Moisturizer glycerin 16 Thickener Carrageenan 0.4 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.4 Sweeteners Trichlorogalactose 0.13 Antibacterial Agents Zinc Citrate / Antibacterial Agents Cetylpyridinium chloride 0.05 Thickener Silicon dioxide (thickening type) 5 Friction agent Silicon dioxide (friction type) 22 Fragrance essence 1.1

[0234] Table 8B4 - Anion Tube

[0235] Raw material properties raw material W% Solvents Deionized water 23.97 Moisturizer Sorbitol 26 Moisturizer glycerin 16 Thickener Carrageenan 0.4 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.4 Sweeteners Trichlorogalactose 0.13 Foaming agent Sodium Lauryl Sulfate 4.0 Anti-inflammatory agents Sodium azulene sulfonate 0.5 Antibacterial Agents Eugenol / Thickener Silicon dioxide (thickening type) 5 Friction agent Silicon dioxide (friction type) 22 Fragrance essence 1.1

[0236] Table 9S—Single tube containing anions and cations

[0237] Raw material properties raw material W% Solvents Deionized water 20.76 Moisturizer Sorbitol 38 Moisturizer PEG-8 8 Thickener Xanthan gum 0.5 Thickener Cellulose Gum 0.5 Appearance Improver Titanium Dioxide 0.3 Sweeteners Trichlorogalactose 0.14 Antibacterial Agents Cetylpyridinium chloride 0.5 Foaming agent Sodium Lauryl Sulfate 3.8 Anti-inflammatory agents Sodium azulene sulfonate 0.2 Antibacterial Agents Eugenol 0.1 Thickener Silicon dioxide (thickening type) 6 Friction agent Silicon dioxide (friction type) 20 Fragrance essence 1.2

[0238] Each embodiment selects the above formula to prepare a double-tube toothpaste, injects Figure 1-Figure 4 The comparative example was prepared as a conventional single tube toothpaste.

[0239] Performance Testing:

[0240] 1. The samples of each embodiment or comparative example were subjected to an antibacterial test according to QB / T 2738-2023 (7.3) Antibacterial effect test method for daily chemical products (suspension quantitative method), and Streptococcus mutans, which is prone to cause dental caries, and Porphyromonas gingivalis, which is prone to cause gum health problems, were selected as test bacteria; the antibacterial action time was 3 minutes;

[0241] Antibacterial test operation steps:

[0242] a. Dilute the test bacterial suspension appropriately with PBS solution. The required concentration is: take 0.1 mL and drop it into 5.0 mL of the control sample solution. The number of recovered bacteria is 1×10 4 ~9×10 4 cfu / mL;

[0243] b. Dilute the test toothpaste sample with sterile purified water at a ratio of 1:2;

[0244] c. Pipette 5.0 mL of the test sample dilution solution into a sterile test tube and keep it at 20°C for 5 minutes;

[0245] d. Pipette 0.1 mL of the test bacterial solution into the test tube containing 5.0 mL of the sample, mix quickly, and start the timer immediately;

[0246] e. After the set time, take 0.5 mL of the test bacteria and sample mixture, add it to a test tube containing 4.5 mL of sterilized PBS, and mix thoroughly;

[0247] f. After 10 minutes, take 1 mL of the sample solution and place it in a sterile plate. Inoculate two sterile plates for each sample solution or dilution. Pour 15 mL of nutrient agar medium cooled to 40℃~45℃, rotate the plate to make it fully uniform, turn the plate over after the agar solidifies, and culture at 35℃ for 48 hours before counting the number of live bacterial colonies;

[0248] g. Replace the test sample with PBS and follow the above steps as the control sample:

[0249] h. Repeat the experiment 3 times and calculate the average value.

[0250] Calculation formula:

[0251] The antibacterial rate was calculated according to the following formula:

[0252] Antibacterial rate (%) = (Ⅰ-Ⅱ) / Ⅰ*100

[0253] In the formula, Ⅰ is the average colony count of the control sample;

[0254] Ⅱ is the average colony count of the test samples;

[0255] The result remains an integer.

[0256] The test results are shown in Table 10:

[0257] Table 10

[0258]

[0259]

[0260] It can be seen from the experimental data in the above table that the samples of each embodiment have an antibacterial effect on the tested strains, while the single-tube comparative examples have no antibacterial effect on the tested strains.

[0261] This shows that the double-tube gum protection toothpaste of the present application has excellent antibacterial effect and can achieve good gum protection effect.

[0262] Furthermore, from the results of the antibacterial test on the oral care products after the above assembly, it can be seen that the specific examples 1 and 3 have the strongest antibacterial correlation with Porphyromonas gingivalis and Streptococcus mutans, and the antibacterial effect of the specific examples 2 and 4 is slightly reduced due to the reduction of the content of the effective antibacterial components; however, in comparative example 1, the antibacterial result of the single oral care product tube prepared by the anionic and cationic effective antibacterial components is reduced to less than 50%, and the effect evaluation according to QB / T 2738-2023 (7.3) is non-antibacterial.

[0263] 2. Simulate clinical trial operation

[0264] The clinical comparative experiment was carried out with reference to the standard "WST 326.3-2010 Toothpaste Efficacy Evaluation Part 3: Inhibition of Dental Plaque and / or Relief of Gingival Inflammation".

[0265] Test group toothpaste: double tube toothpaste of Example 1

[0266] Control group toothpaste: single tube toothpaste of comparative example 1

[0267] A randomized, blinded, parallel controlled trial design was used to evaluate the clinical effects of toothpaste containing sodium lauryl sulfate, sodium azulene sulfonate, cetylpyridinium chloride, and zinc citrate. The significant differences in the modified gingival index MGI, gingival bleeding index GBI, and modified Quigley-Hein plaque index MPI between the groups were used as the primary endpoints. The above three indicators are gingival inflammation examination indicators.

[0268] The test results are shown in Table 11:

[0269] Results Analysis

[0270] Comparison of gingival indexes between the experimental group and the control group after using toothpaste for 6 and 12 weeks

[0271] Table 11 Comparison of ∆MGI, ∆MPI and ∆GBI between the experimental group and the control group at 6 weeks and 12 weeks (X±SD)

[0272]

[0273] Conclusion: The mean reduction of MGI, MPI and GBI in the experimental group was greater than that in the control group, and there were significant differences in ∆MGI, ∆MPI and ∆GBI between the experimental group and the control group at the 6th and 12th weeks, indicating that the toothpaste in the experimental group was significantly better than that in the control group in reducing the modified gingival index and gingival bleeding index, reducing gingival bleeding and inhibiting dental plaque. This fully verifies that the ready-to-mix formula of the double-tube gingival protection toothpaste of this application is better than the single-tube formula after mixing in alleviating gingival-related problems.

[0274] 3. Ultraviolet absorption spectrum experiment of the active ingredients of sodium azulene sulfonate

[0275] Sodium azulene sulfonate can produce a unique absorption spectrum phenomenon due to its special conjugated large π bond, so the absorbance value can be used to characterize the content of sodium azulene sulfonate. Scanned by UV-visible spectrophotometer, it has a characteristic absorption peak at a wavelength of 573nm. The absorbance value of sodium azulene sulfonate and cetylpyridinium chloride was tested after mixing for 30 minutes; and the absorbance value of sodium azulene sulfonate alone at the corresponding concentration.

[0276]

[0277] Sodium azulene sulfonate

[0278] The test results are shown in Table 12:

[0279] Table 12 Absorbance test results after mixing sodium azulene sulfonate (SGS) and cetylpyridinium chloride (CPC)

[0280]

[0281] Result analysis: The absorbance value of sodium azulene sulfonate and cetylpyridinium chloride was tested 30 minutes after mixing. Compared with the absorbance value of sodium azulene sulfonate alone at the corresponding concentration, the absorbance values ​​showed different degrees of decrease rate, and the mixed solution of the two showed obvious flocculation precipitation as the storage time increased, indicating that there was an interaction between anions and cations between sodium azulene sulfonate and cetylpyridinium chloride.

[0282] Therefore, conventional single-tube toothpaste (usually requires pre-mixing before leaving the factory, which takes much longer than 30 minutes) combines cationic antibacterial agents and sodium azulene sulfonate in one paste, which will reduce the effective content of sodium azulene sulfonate; and the content of sodium azulene sulfonate decreases more with longer storage time.

[0283] 4. Results of mixed antibacterial test of sodium azulene sulfonate, cetylpyridinium chloride and sodium lauryl sulfate:

[0284] Carry out antibacterial test with reference to clause 7.3 of QB / T 2738-2023 Evaluation method for antibacterial and antimicrobial effects of daily chemical products.

[0285] 1. The test results of antibacterial test of sodium azulene sulfonate and cetylpyridinium chloride are shown in Table 13-Table 15:

[0286] Table 13 Antibacterial test results of sodium azulene sulfonate (SGS) solution

[0287]

[0288] Table 14 Antibacterial test results of cetylpyridinium chloride (CPC) solution

[0289]

[0290] Table 15 Antibacterial test results of mixed solution of sodium azulene sulfonate (SGS) and cetylpyridinium chloride (CPC)

[0291]

[0292] Test conclusion: The results in Table 15 show that the antibacterial effect of sodium azulene sulfonate and cetylpyridinium chloride mixed in a 2 / 1 molar ratio on Candida albicans is significantly better than that of the mixed sample prepared 20 hours in advance, indicating that sodium azulene sulfonate interacts with cetylpyridinium chloride to reduce the antibacterial activity of cetylpyridinium chloride.

[0293] Phenomenon: The turbidity of the mixed sample of sodium azulene sulfonate and cetylpyridinium chloride becomes more obvious as the storage time increases. It is inferred that the longer the storage time, the more complete the effects of the two.

[0294] Therefore, when the ready-to-mix solution is adopted, the antibacterial rate of cetylpyridinium chloride can be effectively ensured to be within the effective range. At the same time, since sodium azulene sulfonate is not consumed by the reaction with cetylpyridinium chloride, it will not affect the anti-inflammatory effect of sodium azulene sulfonate itself, thereby achieving a good gum protection effect.

[0295] Conventional single-tube toothpaste (usually needs to be pre-mixed before leaving the factory, which is much longer than 20 hours) combines the cationic antibacterial agent and sodium azulene sulfonate in a paste, which will reduce the activity of the cationic antibacterial agent; and as the storage time increases, the activity of the cationic antibacterial agent decreases even more.

[0296] Combined with the above, it can be seen that conventional single-tube toothpaste, which mixes cationic antibacterial agents and sodium azulene sulfonate in one paste, will greatly reduce the antibacterial activity of the cationic antibacterial agent. At the same time, the combination of the two will also reduce the anti-inflammatory effect of sodium azulene sulfonate, thereby affecting the gum protection effect. Especially when it reaches the hands of consumers, it has almost completely lost its true gum protection effect.

[0297] 2. The antibacterial rate test results of the mixed solution of sodium lauryl sulfate and cetylpyridinium chloride are shown in Table 16:

[0298] Table 16 Sodium lauryl sulfate (K 12 ) and cetylpyridinium chloride (CPC) mixed solution antibacterial rate test results

[0299]

[0300] Test results: From the test results in Table 16, it can be seen that sodium lauryl sulfate and cetylpyridinium chloride were mixed in an equal molar ratio of 1 / 1. The mixed solution completely lost its antibacterial effect on Staphylococcus aureus and Candida albicans 3 hours in advance, but the immediate mixed solution still had an antibacterial effect.

[0301] Phenomenon: The mixed solution of sodium lauryl sulfate and cetylpyridinium chloride in equal molar ratio will produce obvious flocculation phenomenon.

[0302] Therefore, when using the mix-and-use solution, it can effectively ensure that the antibacterial rate is within the effective range, achieve good antibacterial and gum protection effects, and at the same time achieve good foaming and stain removal effects.

[0303] Conventional single-tube toothpaste (usually needs to be pre-mixed before leaving the factory, which is much longer than 3 hours) compounds cationic antibacterial agents and anionic surfactants in a paste. The combination of the two will inevitably reduce the activity of the cationic antibacterial agent; and usually the amount of anionic foaming agent added to the toothpaste is several times the amount of cationic antibacterial agent. As the storage time increases, the more the anions and cations act, the more the activity of the cationic antibacterial agent decreases. By the time it reaches the hands of consumers, it has basically completely lost its antibacterial activity and gum protection effect.

[0304] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A gum protection toothpaste, characterized in that: include: An extrusion container, a first paste, and a second paste; the extrusion container comprises: a container body; at least two sub-chambers along the extension direction of the container body; the first paste and the second paste are each contained in one of the sub-chambers; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste.

2. The gum protection toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of sodium azulene sulfonate added to the second paste is 0.01% to 0.5%.

3. The gum protection toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of the anionic foaming agent added to the second paste is 1.0% to 4.0%.

4. The gum protection toothpaste according to claim 1, characterized in that: In terms of mass percentage, the amount of the cationic antibacterial agent added to the first paste is 0.05% to 0.5%.

5. The gum protection toothpaste according to claim 1, characterized in that: The molar ratio of the anionic foaming agent to the cationic antibacterial agent is 1:(0.5-2).

6. The gum protection toothpaste according to claim 1, characterized in that: The molar ratio of the sodium azulene sulfonate to the cationic antibacterial agent is (1-4): (1-2).

7. The gum protection toothpaste according to claim 1, characterized in that: The cationic antibacterial agent comprises at least one of chlorhexidine, cetylpyridinium chloride, olaflur, benzalkonium chloride and benzethonium chloride.

8. The gum protection toothpaste according to claim 1, characterized in that: The anionic foaming agent includes: one or more of sodium lauryl sulfate, sodium lauryl sarcosinate, sodium methyl cocoyl taurate, sodium cocoyl glycinate or sodium cocoyl glutamate.

9. The gum protection toothpaste according to claim 1, characterized in that: The first paste further includes: a soluble zinc salt; in terms of mass percentage, the added amount of the soluble zinc salt is 0.1% to 0.8%.

10. The gum protection toothpaste according to claim 9, characterized in that: The soluble zinc salt includes at least one of zinc citrate, zinc lactate, zinc gluconate, zinc chloride or zinc sulfate.

11. The gum protection toothpaste according to claim 1, characterized in that: The second paste also includes: Chinese herbal antibacterial agent.

12. The gum protection toothpaste according to claim 11, characterized in that: The Chinese herbal antibacterial agent includes at least one of paeonol, eugenol or thymol.

13. The gum protection toothpaste according to claim 11, characterized in that: In terms of mass percentage, the amount of the Chinese herbal antibacterial agent added to the second paste is 0.01% to 0.4%.

14. The gum protection toothpaste according to any one of claims 1 to 13, characterized in that: The first carrier includes: a solvent, a moisturizer, a thickener, an appearance improver, and a friction agent; The solvent includes: water; The moisturizer includes: at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol; The thickener comprises: at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose; The appearance improver includes: titanium dioxide; The friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

15. The gum protection toothpaste according to claim 14, characterized in that: In terms of mass percentage, the first paste includes: 0.05%-0.5% cationic antibacterial agent, 0.1%-0.8% soluble zinc salt; 5%-30% solvent; 35%-60% moisturizer, 0.1%-13% thickener, 0.2%-0.8% appearance improver, and 5%-22% abrasive.

16. The gum protection toothpaste according to any one of claims 1 to 13, characterized in that: The second carrier includes: a solvent, a moisturizer, a thickener, an appearance improver, and a friction agent; The solvent includes: water; The moisturizer includes: at least one of sorbitol, polyethylene glycols, glycerin, and propylene glycol; The thickener comprises: at least one of polyvinyl pyrrolidone, carbomer, xanthan gum, cellulose gum, thickening silicon dioxide, carrageenan, and hydroxyethyl cellulose; The appearance improver includes: titanium dioxide; The friction agent includes at least one of friction-type silica, calcium hydrogen phosphate, calcium pyrophosphate or calcium carbonate.

17. The gum protection toothpaste according to claim 16, characterized in that: In terms of mass percentage, the second paste includes: 0.01% to 0.5% sodium azulene sulfonate, 1.0% to 4.0% anionic foaming agent; 0.01% to 0.4% Chinese herbal antibacterial agent; 5% to 30% solvent; 30% to 60% moisturizer, 0.1% to 13% thickener, 0.2% to 0.8% appearance improver, and 5% to 22% abrasive.

18. The gum protection toothpaste according to any one of claims 1 to 13, characterized in that: The extrusion container also includes: a cover plate, a transmission extrusion structure and a partition plate; The partition is disposed in the chamber, and is used to divide the chamber into at least two sub-chambers along the extension direction of the container body, and the sub-chambers are communicated with the outlet of the container body; The cover plate is detachably connected to the tail of the container body through a connecting structure for sealing; The transmission extrusion structure is disposed in the container body and is movably connected to the cover plate. The transmission extrusion structure is used to extrude the first paste and the second paste in the chamber from the outlet.

19. The gum protection toothpaste according to claim 18, characterized in that: The transmission extrusion structure includes: a transmission member and a piston, one end of the transmission member is movably connected to the cover plate, the transmission member is arranged in the chamber along the extension direction of the container body, the piston is transmission-connected to the transmission member, and the transmission member drives the piston to move forward or backward along the extension direction of the axis of the transmission member to realize the extrusion of the first paste and the second paste.

20. The gum protection toothpaste according to claim 18, characterized in that: The gum protection toothpaste comprises: a base; The base comprises: a base body; A driving component is disposed in the base body; A transmission structure is arranged in the base body and connected to the driving component; a docking component is arranged on the transmission structure, and the docking component is used to be fixedly connected with the transmission extrusion structure in the extrusion container when the base and the extrusion container are assembled; the driving component drives the transmission structure, and then drives the transmission extrusion structure fixedly connected to the docking component to realize the extrusion of the first paste and the second paste; A control module is disposed in the base body and is electrically connected to the driving component; The power supply module is arranged in the base body and is electrically connected to the control module and the driving component respectively.

21. The gum protection toothpaste according to claim 20, characterized in that: The transmission structure includes: a bracket and a transmission member; the transmission member is arranged on the bracket, the output end of the driving member passes through the bracket, and the output end of the driving member is connected to the transmission member, and the docking member is arranged on one end of the transmission member away from the output end of the driving member.

22. A method for preparing a gum protection toothpaste, characterized in that: Extruding a container, a first paste, and a second paste; The extrusion container comprises: a container body; The container body comprises at least two sub-chambers along the extension direction thereof; the first paste comprises: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste comprises: an anionic foaming agent, sodium azulene sulfonate and a second carrier acceptable to toothpaste; The preparation method comprises: The first paste is injected into one of the sub-chambers; and the second paste is injected into another of the sub-chambers.

23. The method for preparing a gum protection toothpaste according to claim 22, characterized in that: In terms of mass percentage, the amount of sodium azulene sulfonate added to the second paste is 0.01% to 0.5%.

24. A gum protection toothpaste, characterized in that: include: Extruding a container, a first paste, and a second paste; The extrusion container comprises: a container body; The container body includes at least two sub-chambers along the extension direction thereof; the first paste and the second paste are respectively contained in one of the sub-chambers; the first paste includes: a cationic antibacterial agent and a first carrier acceptable to toothpaste; the second paste includes: sodium azulene sulfonate and a second carrier acceptable to toothpaste.

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