Acne-removing and inflammation-diminishing composition containing nitrogen-doped nano titanium dioxide and preparation method of acne-removing and inflammation-diminishing composition

Abstract

The invention provides an acne-removing and inflammation-diminishing composition containing nitrogen-doped nano titanium dioxide and a preparation method thereof.The acne-removing and inflammation-diminishing composition is prepared from, by mass, 0.1%-80% of a nitrogen-doped nano titanium dioxide solution, 0.5%-15% of a humectant, 0.05%-5% of a thickening agent and 0.02%-10% of herbal extract, the acne-removing and inflammation-diminishing composition comprises a nitrogen-doped nano titanium dioxide solution, a humectant, herbal extracts and 0.01%-5% of auxiliaries, the content of nitrogen-doped nano titanium dioxide in the nitrogen-doped nano titanium dioxide solution is 0.01%-10%, the nitrogen-doped nano titanium dioxide is particulate matter, and the particle size is 10-60 nm. The acne-removing and inflammation-diminishing composition is formed by combining the nitrogen-doped nano titanium dioxide solution, the humectant, the herbal extracts and the like according to different proportions. The acne-removing and inflammation-diminishing composition has the advantages that the acne-removing and inflammation-diminishing composition has the activity of remarkably improving skin inflammation, is obvious in effect and small in side effect after being used, can play a role under visible light and fluorescent lamps after being sprayed or smeared, does not have toxic or side effects of medicines, and is safe and reliable.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, and in particular to an acne-removing and anti-inflammatory composition containing nitrogen-doped nano titanium dioxide and a preparation method thereof. Background Art

[0002] Acne, also known as "pimples", is caused by excessive secretion of oil from the skin, which causes blockage of the sebaceous gland ducts of the hair follicles, bacterial infection such as Propionibacterium acnes, and inflammatory reactions. Common symptoms include blackheads, whiteheads, nodules, cysts, and papules, which often appear on the face, back, chest, and other skin surfaces. In addition, endocrine disorders caused by excessive fatigue, spicy diets, and emotional tension can also lead to the formation and aggravation of acne.

[0003] At present, the common treatment methods are oral isotretinoin, glucocorticoids, topical clindamycin gel, etc. or combined with physical therapy. These treatments can only produce temporary effects, but cannot completely cure acne. The recurrence rate is extremely high, and it is easy to produce dependence and drug resistance. In addition, there are many contraindications to the drugs, and the applicable population is limited. There are also adverse reactions such as pigmentation and "laser face" in the skin lesions, and even damage to liver and kidney function.

[0004] In order to reduce the occurrence of skin problems such as acne and blackheads, people often use corresponding skin care products to solve such skin problems. At present, various acne-removing and oil-controlling skin care products have appeared on the market. Although they can have a certain inhibitory effect on acne, the efficacy of these products is single and cannot effectively control oil and remove acne. The effect is not ideal. In addition, after use, obvious marks are left on the acne, and the repair effect is not ideal.

[0005] Therefore, it is necessary to provide an acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide and a preparation method thereof to solve the above technical problems. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides an acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide and a preparation method thereof. The composition is composed of a nitrogen-doped nano-titanium dioxide solution, a moisturizer, and a herbal extract in different proportions. The composition has the activity of significantly improving skin inflammation and can be used to prepare functional cosmetics, gels, and the like for acne removal and anti-inflammatory effects.

[0007] The present invention provides an acne-removing and anti-inflammatory composition containing nitrogen-doped nano titanium dioxide. The acne-removing and anti-inflammatory composition is composed of the following raw materials in percentage by mass: 0.1%-80% of a nitrogen-doped nano titanium dioxide solution, 0.5%-15% of a moisturizer, 0.05%-5% of a thickener, 0.02%-10% of a herbal extract, and 0.01%-5% of an auxiliary agent. The nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 0.01%-10%, and the nitrogen-doped nano titanium dioxide is a granular material with a particle size of 10nm-60nm.

[0008] Preferably, the moisturizing agent is one or more of glycerin, propylene glycol, hyaluronic acid, allantoin, hexylene glycol, urea, arginine, butylene glycol, ceramide, oat-β-glucan, and bisabolol.

[0009] Preferably, the herbal extract is one or more of bitter orange peel extract, white willow bark extract, honeysuckle extract, salvia miltiorrhiza root extract, scutellaria baicalensis root extract, oldenlandia diffusa extract, honeysuckle thorn extract, peony root extract, Scrophularia ningpoensis extract, hydrolyzed ginsenosides, Aralia dasyphylla root extract, and Chrysanthemum indica extract.

[0010] Preferably, the thickener is one or more of xanthan gum, hydroxyethyl cellulose, carbomer, and polyacrylamide.

[0011] Preferably, the auxiliary agent is one or more of disodium ethylenediaminetetraacetic acid, phenoxyethanol, isoparaffin, and lauryl alcohol polyether.

[0012] Preferably, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0013] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0014] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0015] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0016] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0017] (5) Finally, calcining at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder, and preparing a 0.1%-80% nitrogen-doped nano-titanium dioxide solution with water according to demand.

[0018] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0019] S1: During preparation, water and 0.01%-5% of an additive by mass are first mixed;

[0020] S2: After dissolution, add 0.5%-15% by weight of a moisturizer and 0.05%-5% by weight of a thickener, and stir evenly;

[0021] S3: Adding 0.02%-10% by mass of herbal extract and 0.1%-80% by mass of nitrogen-doped nano titanium dioxide solution in sequence, wherein the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 0.01%-10% and the particle size is 10nm-60nm, and after complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0022] Compared with the related art, the acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide and the preparation method thereof provided by the present invention have the following beneficial effects:

[0023] 1. The acne-removing and anti-inflammatory composition of the present invention is composed of nitrogen-doped nano-titanium dioxide solution, moisturizer and herbal extract in different proportions, has the activity of significantly improving skin inflammation, and can be used to prepare functional cosmetics, gels and the like for acne-removing and anti-inflammatory purposes. After using the acne-removing and anti-inflammatory composition of the present invention, the effect is obvious and the side effects are small.

[0024] 2. The main components of the acne-removing and anti-inflammatory composition of the present invention are non-drug and non-hormone, and will not cause problems such as drug dependence or hormone disorder, and have strong practicality. At the same time, nitrogen-doped nano-titanium dioxide is the main component, which unexpectedly has acne-removing and anti-inflammatory effects, and has obvious effects at low dosages. At the same time, it has a certain freckle-removing and whitening effect, with small side effects and no irritation. After spraying or applying, it can work under visible light and fluorescent lamps, does not have the toxic side effects of drugs, and is safe and reliable. DETAILED DESCRIPTION

[0025] The present invention is further described below in conjunction with the embodiments.

[0026] It should be noted that nano-titanium dioxide is a semiconductor nanostructure material with quantum confinement, which is mainly used as a physical sunscreen and whitening concealer in cosmetics. The surface-modified nitrogen-doped nano-titanium dioxide quantum dot material has the effect of reducing the number of bacteria on the skin surface and relieving inflammatory reactions, which helps to alleviate the symptoms of acne and blackheads and promote skin repair. Its bactericidal principle is that when it is irradiated with visible light or ultraviolet rays with higher energy, the valence band electrons are excited to the conduction band, and photogenerated electrons and holes are generated at the same time. Photogenerated electrons and holes have strong reducing and strong oxidizing properties, respectively, and can decompose organic matter formed by chemical bonds such as carbon, hydrogen, oxygen, and nitrogen that constitute microorganisms, and finally generate non-toxic and odorless CO2, H2O and some simple inorganic substances, so as to achieve the purpose of killing and inhibiting bacteria, degrading bacterial toxins and residues. In this process, the titanium dioxide material plays the role of a catalyst, which is not consumed itself and has a long-lasting effect, and is not selective for microorganisms. At the same time, these photogenerated electrons and holes can oxidize and degrade the melanin on the surface of the skin, thereby achieving the effect of whitening and removing spots, and penetrate deep into the skin to destroy melanocytes, reduce the formation and accumulation of melanin, and further alleviate the problem of spots.

[0027] Example 1

[0028] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0029] 0.1% nitrogen-doped nano-titanium dioxide solution, wherein the content of nitrogen-doped nano-titanium dioxide in the nitrogen-doped nano-titanium dioxide solution is 10%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 10 nm.

[0030] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0031] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0032] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0033] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0034] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0035] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0036] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0037] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0038] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0039] (5) Finally, the mixture was calcined at 450° C. for 3 h, cooled to room temperature, and ground to obtain nitrogen-doped nano-titanium dioxide powder. A 0.1% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0040] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0041] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0042] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0043] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 0.1% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 10%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0044] Example 2

[0045] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0046] 2% nitrogen-doped nano-titanium dioxide solution, wherein the content of nitrogen-doped nano-titanium dioxide in the nitrogen-doped nano-titanium dioxide solution is 10%, and the nitrogen-doped nano-titanium dioxide is particulate matter with a particle size of 10 nm.

[0047] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0048] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0049] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0050] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0051] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0052] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0053] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0054] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0055] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0056] (5) Finally, the mixture was calcined at 450° C. for 3 h, cooled to room temperature, and ground to obtain nitrogen-doped nano-titanium dioxide powder. A 2% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0057] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0058] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0059] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0060] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 2% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 10%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0061] Example 3

[0062] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0063] 20% nitrogen-doped nano-titanium dioxide solution, wherein the content of nitrogen-doped nano-titanium dioxide in the nitrogen-doped nano-titanium dioxide solution is 10%, and the nitrogen-doped nano-titanium dioxide is particulate matter with a particle size of 10 nm.

[0064] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0065] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0066] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0067] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0068] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0069] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0070] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0071] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0072] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0073] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. A 20% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0074] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0075] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0076] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0077] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 20% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 10%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0078] Example 4

[0079] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0080] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 0.01%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 10 nm.

[0081] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0082] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0083] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0084] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0085] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0086] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0087] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0088] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0089] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0090] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0091] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0092] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0093] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0094] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 0.01%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0095] Example 5

[0096] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0097] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 2%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 10 nm.

[0098] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0099] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0100] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0101] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0102] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0103] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0104] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0105] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0106] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0107] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0108] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0109] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0110] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0111] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 2%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0112] Example 6

[0113] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0114] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 10 nm.

[0115] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0116] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0117] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0118] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0119] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0120] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0121] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0122] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0123] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0124] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0125] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0126] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0127] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0128] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 10 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0129] Example 7

[0130] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0131] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 20 nm.

[0132] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0133] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0134] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0135] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0136] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0137] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0138] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0139] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0140] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0141] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0142] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0143] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0144] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0145] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 20 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0146] Example 8

[0147] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0148] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 60 nm.

[0149] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0150] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0151] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract and 0.25% scutellaria baicalensis root extract.

[0152] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0153] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0154] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0155] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0156] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0157] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0158] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0159] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0160] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0161] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0162] S3: Herbal extracts including 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, 0.25% scutellaria baicalensis root extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 60 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0163] Example 9

[0164] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0165] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 20 nm.

[0166] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0167] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0168] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.3% Hedyotis diffusa extract, 0.3% Honeysuckle extract, 0.3% Salvia miltiorrhiza root extract, and 0.2% Gleditsia sinensis thorn extract.

[0169] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0170] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0171] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0172] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0173] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0174] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0175] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0176] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0177] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0178] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.15% xanthan gum and 0.15% hydroxyethyl cellulose are added and stirred evenly;

[0179] S3: Herbal extracts including 0.3% Hedyotis diffusa extract, 0.3% Honeysuckle extract, 0.3% Salvia miltiorrhiza root extract, 0.2% Gleditsia sinensis thorn extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 20 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0180] Example 10

[0181] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0182] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 20 nm.

[0183] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan and 0.5% arginine.

[0184] 0.05%-5% thickener, specifically, the thickener consists of 0.3% carbomer and 0.2% xanthan gum.

[0185] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, and 0.25% scutellaria baicalensis root extract.

[0186] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0187] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0188] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0189] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0190] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0191] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0192] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0193] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0194] S1: During preparation, water and an auxiliary agent including 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone are first mixed;

[0195] S2: after dissolution, a moisturizer comprising 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat β-glucan and 0.5% arginine and a thickener comprising 0.3% carbomer and 0.2% xanthan gum are added and stirred evenly;

[0196] S3: Herbal extracts including 0.3% Hedyotis diffusa extract, 0.3% Honeysuckle extract, 0.3% Salvia miltiorrhiza root extract, 0.2% Gleditsia sinensis thorn extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 20 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0197] Embodiment 11

[0198] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0199] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 20 nm.

[0200] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 5% glycerin, 3% propylene glycol, 0.2% urea, 0.3% ceramide, and 0.5% bisabolol.

[0201] 0.05%-5% thickener, specifically, the thickener consists of 0.3% carbomer, 0.2% xanthan gum and 0.2% polyacrylamide.

[0202] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% peony root extract, 0.25% Scrophularia ningpoensis extract, 0.25% hydrolyzed ginsenosides, 0.25% Aralia elata root extract, and 0.25% Chrysanthemum indica extract.

[0203] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.05% isoparaffin, 0.05% lauryl alcohol polyether, 0.5% phenoxyethanol and 0.5% p-hydroxyacetophenone.

[0204] In this embodiment, the steps of preparing the nitrogen-doped nano-titanium dioxide solution include:

[0205] (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min;

[0206] (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes;

[0207] (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours;

[0208] (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h;

[0209] (5) Finally, calcining was performed at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder. An 80% nitrogen-doped nano-titanium dioxide solution was prepared with water according to demand.

[0210] The present invention also provides a method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, comprising the following steps:

[0211] S1: During preparation, water and an auxiliary agent including 0.05% isoparaffin, 0.05% laureth, 0.5% phenoxyethanol, and 0.5% p-hydroxyacetophenone are first mixed;

[0212] S2: After dissolution, a moisturizer comprising 5% glycerin, 3% propylene glycol, 0.2% urea, 0.3% ceramide, and 0.5% bisabolol and a thickener comprising 0.3% carbomer, 0.2% xanthan gum, and 0.2% polyacrylamide are added and stirred evenly;

[0213] S3: Herbal extracts including 0.25% peony root extract, 0.25% Scrophularia ningpoensis extract, 0.25% hydrolyzed ginsenosides, 0.25% Aralia elata root extract, 0.25% Chrysanthemum indica extract and 80% by mass of nitrogen-doped nano titanium dioxide solution are added in sequence, and the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the particle size is 20 nm. After complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

[0214] Example 12

[0215] The present invention provides an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, wherein the anti-acne and anti-inflammatory composition is composed of the following raw materials in percentage by mass:

[0216] 80% nitrogen-doped nano-titanium dioxide solution, wherein the nitrogen-doped nano-titanium dioxide content in the nitrogen-doped nano-titanium dioxide solution is 1%, and the nitrogen-doped nano-titanium dioxide is a particle with a particle size of 20 nm.

[0217] Comparative Example 1

[0218] The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide provided in Comparative Example 1 is composed of the following raw materials in percentage by mass:

[0219] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan, and 0.5% arginine.

[0220] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0221] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, and 0.25% scutellaria baicalensis root extract.

[0222] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0223] Comparative Example 2

[0224] Comparative Example 2 provides an acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, which is composed of the following raw materials in percentage by mass:

[0225] 80% nano titanium dioxide solution (undoped), wherein the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 1%, and the nitrogen-doped nano titanium dioxide is a granular material with a particle size of 20 nm.

[0226] 0.5%-15% moisturizing agent, specifically, the moisturizing agent consists of 0.15% allantoin, 3% butylene glycol, 0.2% hyaluronic acid, 0.5% hexylene glycol, 0.5% oat beta-glucan, and 0.5% arginine.

[0227] 0.05%-5% thickener, specifically, the thickener consists of 0.15% xanthan gum and 0.15% hydroxyethyl cellulose.

[0228] 0.02%-10% herbal extract, specifically, the herbal extract consists of 0.25% bitter orange peel extract, 0.25% white willow bark extract, 0.25% honeysuckle extract, 0.25% salvia miltiorrhiza root extract, and 0.25% scutellaria baicalensis root extract.

[0229] 0.01%-5% auxiliary agent, specifically, the auxiliary agent consists of 0.2% disodium ethylenediaminetetraacetic acid and 0.5% p-hydroxyacetophenone.

[0230] The proportions of the above embodiments and comparative examples are shown in Table 1 below:

[0231] Table 1 shows the ratios of different embodiments and comparative examples.

[0232]

[0233]

[0234]

[0235]

[0236]

[0237] In the above-mentioned Examples 1-6, the proportion of nitrogen-doped nano-titanium dioxide in the formula is different; in Examples 6-8, the particle size of nitrogen-doped nano-titanium dioxide is different; compared with Example 9 and 7, different plant extracts are selected; compared with Example 10 and 7, different thickeners are selected, and a gel is prepared; compared with Example 11 and 7, different thickeners and plant extracts are selected, and a cream is prepared; Example 12 contains only nitrogen-doped nano-titanium dioxide solution; compared with Comparative Example 1 and 7, no nano-titanium dioxide solution is contained; compared with Comparative Example 2 and 7, the nano-titanium dioxide contained is non-nitrogen-doped.

[0238] Experimental process and results

[0239] 1. Inhibition of Propionibacterium acnes

[0240] Take a Propionibacterium acnes bacterial suspension with a concentration of 1×107-108 CFU / mL, apply the bacterial suspension to the culture medium using a coating rod, and then drip Examples 1-12 and Comparative Examples 1-2 into the culture medium as the test group, and drip physiological saline as the blank control group. The culture medium is cultured in an incubator at 37°C for 2 days and then taken out to measure the diameter of the inhibition zone of the culture dish. Three samples are set for each group, and the average value of the measurement results is taken. The test results are shown in Table 1.

[0241] 2. Acne removal and oil control test results

[0242] A test population of 70 persons aged 15-40 years old, half of whom were male and half were female and had obvious acne and blackheads on their faces, were selected and divided into 14 groups, with 5 persons in each group. The samples prepared in Examples 1-12 of the present invention and Comparative Examples 1-2 were applied to the face once in the morning and once in the evening every day, with the same dosage, for 14 consecutive days. No other substances were used during the test.

[0243] Skin care products, the blank control group did not apply any acne-removing and oil-control products and other cosmetics. After 14 days, the number of people whose acne-removing and oil-control effects were effectively reduced was counted (effective judgment criteria are: acne disappears without redness and swelling, acne marks are very light, and the face is wiped with degreasing paper, and there is obviously no oil stain). The test results are shown in Table 2 below.

[0244] Table 2 shows the test results of different embodiments and comparative examples.

[0245] Experimental groups Diameter of inhibition zone, mm Number of people who have achieved effective results in acne removal and oil control Example 1 24.0 3 Example 2 28.2 4 Example 3 29.8 5 Example 4 23.5 3 Example 5 29.8 5 Example 6 29.4 5 Example 7 28.0 4 Example 8 24.6 3 Example 9 29.2 5 Example 10 28.0 4 Embodiment 11 25.8 3 Example 12 25.4 3 Comparative Example 1 21.4 2 Comparative Example 2 22.6 2 Blank control group 6.5 1

[0246] In summary, it is concluded that the acne-removing and anti-inflammatory composition of the present application has significant clinical effects, and has the effects of removing acne, reducing inflammation, controlling oil, removing acne marks, and lightening spots. It has strong practicality and is worthy of clinical promotion and use.

[0247] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device that includes a series of elements includes not only those elements, but also other elements that are not explicitly listed, or includes elements that are inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device that includes the elements.

Claims

1. An anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, characterized in that: The acne-removing and anti-inflammatory composition is composed of the following raw materials in percentage by mass: 0.1%-80% of a nitrogen-doped nano titanium dioxide solution, 0.5%-15% of a moisturizer, 0.05%-5% of a thickener, 0.02%-10% of a herbal extract, and 0.01%-5% of an auxiliary agent. The nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 0.01%-10%, and the nitrogen-doped nano titanium dioxide is a granular material with a particle size of 10nm-60nm.

2. The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide according to claim 1, characterized in that: The moisturizing agent is one or more of glycerin, propylene glycol, hyaluronic acid, allantoin, hexylene glycol, urea, arginine, butylene glycol, ceramide, oat-β-glucan, and bisabolol.

3. The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide according to claim 1, characterized in that: The herbal extract is one or more of bitter orange peel extract, white willow bark extract, honeysuckle extract, salvia miltiorrhiza root extract, scutellaria baicalensis root extract, oldenlandia diffusa extract, honeysuckle thorn extract, peony root extract, Scrophularia ningpoensis extract, hydrolyzed ginsenosides, Aralia elata root extract, and wild chrysanthemum extract.

4. The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide according to claim 1, characterized in that: The thickener is one or more of xanthan gum, hydroxyethyl cellulose, carbomer and polyacrylamide.

5. The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide according to claim 1, characterized in that: The auxiliary agent is one or more of disodium ethylenediaminetetraacetic acid, phenoxyethanol, isoparaffin, and lauryl alcohol polyether.

6. The acne-removing and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide according to claim 1, characterized in that: The preparation steps of the nitrogen-doped nano titanium dioxide solution include: (1) Add anhydrous ethanol to a stirring tank, then slowly add tetrabutyl titanate, and stir at a speed of 600 r / min for 30 min; (2) Add acetic acid, ethylenediamine and a small amount of water in sequence and continue stirring for 30 minutes; (3) placing the above mixed solution in a polytetrafluoroethylene high temperature reactor and reacting at 120°C for 20 hours; (4) Cool to room temperature, wash with deionized water and anhydrous ethanol in an ultrasonic cleaner and centrifuge for three times, remove the supernatant, adjust the centrifuge speed to 10000 r / min, the centrifugation time to 10 min, and then dry in a vacuum drying oven at 80 ° C for 12 h; (5) Finally, calcining at 450° C. for 3 h, cooling to room temperature, and grinding to obtain nitrogen-doped nano-titanium dioxide powder, and preparing a 0.1%-80% nitrogen-doped nano-titanium dioxide solution with water according to demand.

7. A method for preparing an anti-acne and anti-inflammatory composition containing nitrogen-doped nano-titanium dioxide, characterized in that: The following steps are involved: S1: During preparation, water and 0.01%-5% of an additive by mass are first mixed; S2: After dissolution, add 0.5%-15% by weight of a moisturizer and 0.05%-5% by weight of a thickener, and stir evenly; S3: Adding 0.02%-10% by mass of herbal extract and 0.1%-80% by mass of nitrogen-doped nano titanium dioxide solution in sequence, wherein the nitrogen-doped nano titanium dioxide content in the nitrogen-doped nano titanium dioxide solution is 0.01%-10% and the particle size is 10nm-60nm, and after complete dissolution, an acne-removing and anti-inflammatory composition is obtained.

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