Traditional Chinese medicine composition for treating skin red, swollen, heat and pain lesion and preparation method of traditional Chinese medicine composition

Abstract

The invention relates to the field of new traditional Chinese medicines, and particularly provides a traditional Chinese medicine composition for treating skin red, swollen, heat and pain lesions and a preparation method thereof.The composition is composed of a component A and a component B. The component A contains radix isatidis, cortex lycii radicis, radix puerariae, fructus gardeniae, radix sophorae flavescentis and rhizoma polygoni cuspidati; the component B comprises radix trichosanthis, cortex phellodendri, rhizoma curcumae longae, radix et rhizoma rhei, radix angelicae, cortex magnoliae officinalis, pericarpium citri reticulatae, rhizoma atractylodis and liquorice; when the composition is applied, a certain amount of the liquid medicine A and a certain amount of the powder B are mixed and stirred into paste, the paste is wrapped with single-layer gauze, the paste is externally applied to a sick and painful part, and the paste is taken down after being fixed and left for 1 hour, and the composition has the effects of clearing away heat and toxic materials, cooling blood and drying dampness, dissipating blood stasis and activating collaterals and relieving swelling and pain. All the medicines are used together, so that the traditional Chinese medicine composition has a remarkable curative effect on skin soft tissue red, swollen, hot and pain lesions caused by adult gout, skin soft tissue infection, fracture, sprain and the like.

Description

Technical Field

[0001] The invention relates to the field of new Chinese medicines, and in particular to a Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions and a preparation method thereof. Background Art

[0002] Skin and soft tissue lesions caused by gout, skin and soft tissue infection, fractures, sprains, etc. are a common type of skin and soft tissue pathological state. Clinically, they are often red, swollen and painful. If not treated in time, they are prone to secondary damage such as infection, enlargement of lesion area, and aggravation of the disease, which seriously affect the patient's psychological state and daily life. Its etiology and pathogenesis vary with different diseases: among them, gout is caused by elevated uric acid, and uric acid crystals are deposited in the joints of the extremities, irritating the surrounding soft tissues, causing symptoms such as redness, swelling, heat and pain; skin and soft tissue infection is mostly caused by local bacterial infection of the skin, causing inflammatory reaction, redness, swelling, heat and pain, secretion of purulent secretions, etc.; fractures and sprains are mostly caused by trauma, and local tissue damage, local congestion, edema, and pain after injury. If it is an open wound, it is often accompanied by infection.

[0003] "Lingshu·Ulcers" states: "When the nourishing qi is retained in the meridians, the blood will weep but not flow. If it does not flow, the defensive qi will follow and not flow. It is blocked and cannot flow, so it is hot. If the heat does not stop, the flesh will rot, and the rotten flesh will become pus." It points out that if the blood vessels of the body are blocked and the qi and blood are not flowing, heat and pus will occur. "Lingshu·Jingmai" says: "Bone is the trunk, veins are the nourishment, tendons are the hardness, and flesh is the wall." "Lingshu·Xieke" says: "The nourishing qi secretes its body fluids and injects them into the veins, which turns into blood to nourish the four extremities and inject into the five internal organs and six bowels." The above "Huangdi Neijing·Lingshu" shows that the skin, flesh, tendons and bones of the human body are closely related to the five internal organs and six bowels in the body. Various factors lead to tissue damage, just like holes in the wall and sinuses in the wall, which is like a door opening, making it easy for external evil to invade; or if qi and blood stagnate and go against the flesh, the nourishing qi will not follow, and it will be depressed and turn into heat, just like closing the door to retain evil, so that the stasis and heat become poison. When Qi and blood stagnate, the accumulated heat turns into fire, causing pus and causing symptoms such as local redness, swelling, heat, and pain.

[0004] There are many methods for treating red, swollen, hot and painful skin and soft tissue lesions caused by gout, skin and soft tissue infections, fractures, sprains, etc. in adults. The symptomatic treatment of gout is mainly based on oral non-steroidal anti-inflammatory analgesics, skin and soft tissue infections are mainly based on the application of anti-infective drugs, fractures and sprains are mainly based on cold compresses and external application of ice and saltpeter powder, etc. However, there are problems such as poor clinical efficacy and inability to quickly and effectively relieve the patient's pain, and there are side effects of varying degrees, such as gastrointestinal irritation symptoms, intestinal flora imbalance, fungal infection, liver and kidney damage, etc.

[0005] Therefore, whether it is possible to combine the current status of Chinese medicine science in my country to better complete the treatment of red, swollen, hot and painful lesions of skin and soft tissues has become an urgent problem to be solved. Summary of the invention

[0006] In view of the deficiencies of the prior art, the present invention provides a Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions and a preparation method thereof. The composition is composed of two components AB, wherein the component A contains Radix Isatidis, Cortex Lycii, Radix Puerariae, Fructus Gardeniae, Sophorae Flavescentis and Polygonum Cuspidati; the component B contains Radix Trichosanthis, Cortex Phellodendri, Curcuma Longa, Radix Rhei, Angelica Dahuricae, Cortex Magnoliae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae; and the component A is decocted to extract juice, and the component B is ground into powder and mixed evenly. When applied, a certain amount of the A liquid medicine is mixed with a certain amount of the B powder to form a paste, which is wrapped with a single layer of gauze and applied externally to the affected area, fixedly retained for 1 hour and then removed. The composition has the effects of clearing away heat and detoxifying, cooling blood and drying dampness, dispersing blood stasis and activating collaterals, and reducing swelling and relieving pain. The combination of the medicines has a significant effect on the redness, swelling, heat and pain-like lesions of skin and soft tissues caused by gout, skin and soft tissue infections, fractures, sprains, etc. in adults.

[0007] The inventor found in the clinical practice that patients with red, swollen, hot and painful skin and soft tissue lesions caused by adult gout, skin and soft tissue infection, fracture, sprain, etc., have the pathogenesis of heat and toxic accumulation and blood stasis blocking the collaterals, and the current Chinese medicine treatment has no clinical guidelines and treatment standards for this pathogenesis. Therefore, based on the above-mentioned "pathogenesis of heat and toxic accumulation and blood stasis blocking the collaterals", the inventor combined the existing classic prescription "Ruyi Jinhuang San" to obtain the technical solution of this application. The processed Arisaema in the original prescription of "Ruyi Jinhuang San" is very likely to cause skin discomfort and allergic reactions. The inventor removed it and screened other drugs for matching. The Chinese medicine composition finally obtained has the effects of clearing away heat and detoxification, cooling blood and drying dampness, dispersing blood stasis and activating collaterals, and reducing swelling and relieving pain.

[0008] The specific technical solutions of the present invention are as follows:

[0009] A Chinese medicine composition for treating red, swollen, hot and painful skin lesions, the composition is composed of two components A and B, wherein component A contains Radix Isatidis, Cortex Lycii, Radix Puerariae, Fructus Gardeniae, Sophorae Flavescentis and Polygonum Cuspidati; component B contains Radix Trichosanthis, Cortex Phellodendri, Curcuma Longa, Rhubarb, Angelica Dahuricae, Magnolia Officinalis, Pericarpium Citri Reticulatae, Atractylodes Macrocephalae and Licorice:

[0010] More specifically, the components are calculated by weight:

[0011] Component A: 80-150 parts of Radix Isatidis, 80-150 parts of Cortex Lycii, 80-150 parts of Radix Puerariae, 40-100 parts of Gardenia, 15-50 parts of Sophora flavescens, and 40-100 parts of Polygonum cuspidatum.

[0012] Component B: 80-200 parts of Radix Trichosanthis, 40-100 parts of Phellodendron, 40-100 parts of Curcuma, 40-100 parts of Rhubarb, 40-100 parts of Angelica dahurica, 15-40 parts of Magnolia officinalis, 15-40 parts of Tangerine Peel, 15-40 parts of Atractylodes, and 15-40 parts of Licorice.

[0013] Preferably, component A is calculated by weight: 100-120 parts of Isatis root, 100-120 parts of Lycium bark, 100-120 parts of Pueraria root, 50-80 parts of Gardenia, 20-40 parts of Sophora flavescens, and 50-80 parts of Polygonum cuspidatum; component B is calculated by weight: 100-150 parts of Trichosanthes, 50-80 parts of Phellodendron chinense, 50-80 parts of Curcuma longa, 50-80 parts of Rhubarb, 50-80 parts of Angelica dahurica, 20-30 parts of Magnolia officinalis, 20-30 parts of Citrus reticulata, 20-30 parts of Atractylodes, and 20-30 parts of Licorice.

[0014] Furthermore, the inventors have rationally optimized the above components and finally obtained the following optimal technical solution: Component A is calculated by weight: 100 parts of Isatis root, 100 parts of Lycium bark, 100 parts of Pueraria root, 50 parts of Gardenia, 20 parts of Sophora flavescens, and 50 parts of Polygonum cuspidatum; Component B is calculated by weight: 100 parts of Trichosanthes, 50 parts of Phellodendron chinense, 50 parts of Curcuma longa, 50 parts of Rhubarb, 50 parts of Angelica dahurica, 20 parts of Magnolia officinalis, 20 parts of Tangerine peel, 20 parts of Atractylodes, and 20 parts of Licorice.

[0015] The more specific medication mechanism of the above-mentioned Chinese medicine composition is as follows:

[0016] Isatis root is bitter and cold in nature. It enters the heart and stomach meridians and has the functions of clearing away heat and detoxifying, cooling blood and relieving sore throat. It is mainly used to treat fever, erysipelas, carbuncle and sore. Modern pharmacological studies have shown that Isatis root contains indigo, indirubin, β-sitosterol, palmitic acid, uridine, hypoxanthine, uracil, indigo ketone and carrot glycoside. This product has inhibitory effects on a variety of Gram-positive bacteria, Gram-negative bacteria, influenza virus, arbovirus and mumps virus. It has a significant antipyretic effect. It has an antioxidant effect. "Classification of Herbal Properties" says: "It can relieve various poisons and sores, disperse toxins and relieve heat, and can be taken or applied as juice."

[0017] Radix Lycii, sweet, cold, enters the lung, liver, kidney meridians. It can cool blood, remove steam and reduce fire. Sweet and cold enter the blood, can clear heat, cool blood, and stop bleeding. Contains cinnamic acid and a large amount of phenolic substances, betaine, β-sitosterol, linoleic acid, linolenic acid, etc. The decoction of Radix Lycii has immunomodulatory effects and antimicrobial effects. It has a strong inhibitory effect on Salmonella typhi, Salmonella paratyphi A and Shigella flexneri, and has an inhibitory effect on the cytopathic effect of the influenza A virus strain in Asia, Jingke 68-1. The extract of Radix Lycii can significantly increase the pain threshold and has a significant inhibitory effect on physical and chemical pain. "Pearl Capsule": "It can relieve bone steaming and muscle heat, quench thirst, rheumatism, strengthen tendons and bones, and cool blood."

[0018] Pueraria root is sweet, pungent and cool. It enters the spleen and stomach meridians. It has the functions of relieving muscle and reducing fever, clearing rash, promoting body fluid and quenching thirst, and raising yang and stopping diarrhea. It can be used to treat measles that does not clear up. In this recipe, Pueraria root is used to play the role of expelling evil spirits. Modern research shows that Pueraria root contains flavonoids such as daidzein, daidzein, puerarin, as well as daidzein-4,7-diglucoside, pueraria alcohol, puerarin, isoflavone glycosides and starch. Pueraria root can directly dilate blood vessels, improve microcirculation, increase local microblood flow, and inhibit platelet aggregation. It has a significant antipyretic effect. "Shennong's Herbal Classic" says: "It cures thirst...all kinds of arthralgia, raises yin qi, and eliminates all poisons." "Famous Doctors' Records" says: "It opens the pores, treats wounds, and relieves pain." "Yao Xing Lun" says: "Boiled crumbs can treat wounds."

[0019] Gardenia is bitter and cold, and it enters the heart, lung and triple burner meridians. It has the functions of purging fire and relieving restlessness, clearing away heat and dampness, cooling blood and detoxifying. It can treat fire poison sores, redness, swelling, heat and pain. Modern pharmacological studies have shown that gardenia contains isogardenia glycoside, dehydroxygardenia glycoside, gardenia ketone glycoside, triterpenoid compound crocin, etc. It has an inhibitory effect on Staphylococcus aureus, meningococcus, catarrhalis, etc., and its water extract has an inhibitory effect on a variety of skin fungi in vitro. "Shennong's Herbal Classic": "(Gardenia) is the main five internal evil qi, heat in the stomach, red face, alcohol sores, sniffing nose, white scabies, red scabies, and sores."

[0020] Sophora flavescens, bitter and cold, enters the heart, liver, stomach, large intestine, and bladder meridians. It has the functions of clearing away heat and dampness, killing insects, and diuresis. Modern pharmacological studies have shown that Sophora flavescens contains alkaloids such as matrine, oxymatrine, sophoracarpine, and sophoramine, as well as flavonoid compounds such as bitter alcohol C, bitter alcohol G, and matrine. Its decoction has an inhibitory effect on tuberculosis bacteria, Shigella dysenteriae, Staphylococcus aureus, and Escherichia coli, and also has an inhibitory effect on a variety of skin fungi, and has anti-inflammatory, anti-allergic, and sedative effects. "Ben Cao Zheng Yi" says: "Sophora flavescens, very bitter and cold, can reduce fever and drain, and cleanse dampness and fire. Its efficacy is similar to that of Scutellaria baicalensis, Coptis chinensis, and Gentiana scabra, but Sophora flavescens is more bitter and its dryness is particularly strong, so it can kill insects caused by dampness and heat, and its power is stronger than that of Scutellaria baicalensis and Coptis chinensis."

[0021] Polygonum cuspidatum, slightly bitter, slightly cold, enters the liver, gallbladder, and lung meridians, can clear away heat and detoxify, disperse blood stasis and relieve pain. Treats burns from water or fire, carbuncle, sore, snake bites, traumatic injuries, etc. Contains polysaccharides, flavonoids, rhamnolide, rhamnolide methyl ether, resveratrol, and polysaccharides. The decoction has an inhibitory effect on many bacteria such as Staphylococcus aureus / Pseudomonas aeruginosa. It also has an inhibitory effect on certain viruses. "Rihuazi Bencao": "It can discharge pus, treat sores, carbuncle, women fainting, blood stasis caused by beating, and break wind poison and qi stagnation."

[0022] Radix Trichosanthis, sweet, slightly bitter, slightly cold, belongs to the lung and stomach meridians. It can clear away heat and purge fire, promote the production of body fluids and quench thirst, reduce swelling and discharge pus. It can treat fever, thirst, sores, swelling and poison. This product contains starch, saponins, polysaccharides, amino acids, enzymes and Radix Trichosanthis protein. Radix Trichosanthis protein has both immunostimulatory and immunosuppressive effects; Radix Trichosanthis decoction has a certain inhibitory effect on hemolytic streptococci, pneumococci, and diphtheria. "Shennong's Herbal Classic": "It calms the middle and heals the wound." "Rihuazi's Herbal Classic": "It discharges pus, reduces swelling and poison, promotes muscle growth, and eliminates blood stasis. It treats mania, mastitis, back pain, hemorrhoids, fistulas, sores and furuncles."

[0023] Phellodendron chinense is bitter and cold, and it enters the kidney, bladder, and large intestine meridians. It has the functions of clearing away heat and dampness, purging fire and removing steam, and detoxifying and curing sores. It can be used to treat sores, swellings, and can be taken orally or applied externally. Phellodendron chinense contains a variety of alkaloids such as berberine, phellodendrine, magnolia alkaloids, jatrorrhizine, and palmitoyl tetrandrine, as well as effective substances such as phellodendron lactone, phellodendron ketone, phellodendron acid, and sterols. It has anti-pathogenic microbial effects, and has inhibitory effects on a variety of pathogenic bacteria such as Shigella dysenteriae, Salmonella typhi, Mycobacterium tuberculosis, Staphylococcus aureus, and hemolytic Streptococcus; it also has inhibitory effects on certain skin fungi, leptospira, and hepatitis B surface antigen.

[0024] Turmeric is pungent, bitter, warm, and enters the liver and spleen meridians. It has the functions of promoting blood circulation, promoting qi, and relieving pain. Its pungent, dispersing, warming, and bitter properties can enter both the blood and qi, and can promote blood circulation, promote qi, and relieve pain. It can treat injuries from falls, bruises, and pain. It contains volatile oils, the main components of which are turmeric ketone, gingerol, phellandrene, sabinene, eucalyptol, curcumone, caryophyllene, camphor; pigments, mainly curcumin; as well as bixin and norbixin and trace elements. Curcumin can inhibit platelet aggregation, reduce plasma viscosity and whole blood viscosity; curcumin has anti-inflammatory effects and has an inhibitory effect on bacteria, while volatile oil has a strong inhibitory effect on fungi. "Newly Revised Materia Medica" states: "It can lower qi, break blood, eliminate wind and heat, and eliminate carbuncle and swelling, and its power is stronger than that of Curcuma". "Rihuazi Materia Medica" states: "It can treat carbuncle and swelling...it can treat blood stasis caused by falls, and eliminate swelling and poison..."

[0025] Rhubarb: bitter, cold, enters the spleen, stomach, large intestine, liver, and pericardium meridians. It can clear away heat and purge fire, cool blood and detoxify, remove blood stasis and dredge the menstrual channels. It can treat heat-toxic sores, burns, bruises, and blood stasis and swelling. Modern pharmacological studies have shown that the chemical components of rhubarb are mainly anthraquinone derivatives, mainly including anthraquinone glycosides and dianthraquinone glycosides. It also contains tannins, organic acids, and estrogen-like substances. Rhubarb has anti-infective effects, inhibits a variety of Gram-positive and Gram-negative bacteria, and also inhibits influenza viruses. In addition, it has hemostasis, liver protection, blood pressure reduction, and cholesterol-lowering effects. "Yao Xing Lun": "Apply to heat-toxic swelling... corrode pus, break and leave blood." "Compendium of Materia Medica": "(Rhubarb is the main) fire sores."

[0026] Angelica dahurica: pungent, warm, enters the lung, stomach, and large intestine meridians. It can dispel wind and relieve pain, reduce swelling and discharge pus. It is pungent, dispersing, warming, and unblocking. For those with red, swollen, hot, and painful skin, it can relieve swelling and relieve pain. Modern pharmacological studies have shown that Angelica dahurica mainly contains volatile oils, and contains a variety of coumarin compounds such as imperatorin and white angelica, as well as Angelica dahurica toxins, prickly ash toxins, sterols, stearic acid, etc. The decoction of Angelica dahurica has a certain inhibitory effect on Escherichia coli, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, and Proteus. The water extract has a certain inhibitory effect on pathogenic fungi such as Microsporum audouinum. "Compendium of Materia Medica": "It can relieve arsenic poisoning, snake bites, and wounds caused by knives and arrows."

[0027] Magnolia officinalis: bitter, pungent, warm, enters the spleen, stomach, lung, and large intestine meridians. It has the effects of drying dampness and eliminating phlegm, and removing qi and fullness. Modern research shows that the chemical composition of this product contains volatile oil, the oil mainly contains β-eudes alcohol and magnolol. In addition, it also contains a small amount of magnolia curare toxin, magnolia alkaloid tannin, etc. Magnolia officinalis decoction has an inhibitory effect on pneumococcus, diphtheria bacillus, hemolytic streptococcus, Bacillus subtilis, Shigella dysenteriae, Staphylococcus aureus, anthrax bacillus and some skin fungi. Magnolia officinalis and magnolia curare toxin can relax striated muscles. "Shennong's Herbal Classic": "It can cure qi and blood stagnation, dead muscles, and remove three worms."

[0028] Tangerine peel: pungent, bitter, warm, enters the spleen and lung meridians. Functions: regulating qi and strengthening the spleen, drying dampness and resolving phlegm. This product is pungent and fragrant, good at regulating qi, promoting qi and relieving pain. Modern research shows that tangerine peel contains nobiletin, hesperidin, neohesperidin, hesperidin, hydroxyforin, flavonoid compounds, etc. The volatile oil content of tangerine peel is 1.2%-3.2%, and its components include α-thujene, limonene, etc. Tangerine peel extract has the effect of scavenging oxygen free radicals and resisting lipid peroxidation.

[0029] Atractylodes: pungent, bitter, warm, enters the spleen, stomach, and liver meridians. It can dry dampness, dispel wind and cold. This product is pungent, dispersing, bitter and dry, good at removing dampness, and effective for swelling and pain. Modern pharmacological research shows that Atractylodes contains volatile oil, the oil mainly contains atractylol (a mixed crystal of β-eudesyl alcohol and atractylol). Others also contain small amounts of atractylone, vitamin A-like substances, vitamin B and inulin. "Shennong's Herbal Classic": "It treats wind-cold-dampness arthralgia, dead muscle spasm and jaundice." "Famous Doctors' Records": "It eliminates phlegm and water, and removes wind and water swelling between the skin."

[0030] Licorice: sweet, flat. It enters the heart, lung, spleen, and stomach meridians. It can relieve pain, clear away heat and detoxify, and harmonize various medicines. This product is sweet and can relieve urgency, and is good at relieving pain. This product is also good at detoxification and is widely used. It has a slightly cold medicinal property and can clear away heat and detoxify. It is used to treat heat toxic sores and ulcers, and can be used alone for decoction and soaking. This product can also play a role in harmonizing the properties of medicines: by detoxification, it can reduce the toxicity of certain drugs in the prescription; by relieving pain, it can relieve the irritation of certain drugs in the prescription. Modern pharmacological studies have shown that this product contains triterpenes (the potassium and calcium salts of the triterpenoid saponin glycyrrhizic acid are glycyrrhizin, which is the sweet component of licorice), flavonoids, alkaloids, polysaccharides and other ingredients. It has anti-ulcer and analgesic effects. It has antibacterial, antiviral, anti-inflammatory and anti-allergic effects. It has a detoxification effect similar to glucuronic acid on certain poisons; it has an effect similar to adrenal cortex hormone. "Bencao Huiyan" says: "It is a medicine that harmonizes the stomach, replenishes Qi, replenishes deficiency and detoxifies." "Bencao Zheng" says: "It tastes very sweet and has a neutralizing nature. It has the function of regulating and replenishing. Therefore, poisonous drugs can be neutralized by it, and strong drugs can be harmonized by it."

[0031] In the above-mentioned Chinese medicine composition, component A uses Radix Isatidis as the main medicine. Radix Isatidis is bitter and cold in nature, and it enters the heart and stomach meridians. It has the functions of clearing away heat and detoxifying, cooling blood, and relieving sore throat. It is reused in this prescription to clear away heat and detoxify and cool blood, and promote the dissipation of heat and toxic evil spirits. Gardenia and Sophora flavescens are ministerial medicines. Gardenia is bitter and cold, and enters the heart, lung, and triple burner meridians. It has the effects of purging fire and relieving restlessness, clearing heat and removing dampness, cooling blood and detoxifying. It is mainly used for heat syndromes such as fire poison sores and carbuncles. Sophora flavescens is bitter and cold, and enters the heart, liver, stomach, large intestine, and bladder meridians. It can clear heat and dry dampness. The two medicines are used together to help the main medicine clear heat and detoxify, cool blood and reduce swelling. Pueraria root is sweet, spicy, and cool, and enters the spleen and stomach meridians. It has the functions of relieving muscle and reducing fever, penetrating rash, and can penetrate evil and go out; Rehmannia root bark is sweet and cold, can cool blood and remove steaming, and is an adjuvant. Polygonum cuspidatum is slightly bitter and slightly cold, can clear heat and detoxify, disperse blood stasis and relieve pain, and is a messenger. The whole formula has the effects of clearing away heat, detoxifying, reducing swelling and relieving pain.

[0032] In component B, Radix Trichosanthis, Cortex Phellodendri, and Radix Rhei are the main drugs, which are bitter and cold, clearing away heat and purging fire, cooling blood and detoxifying, and reducing swelling and discharging pus. "Blood harmony can reduce swelling and stop pain", and turmeric is used to promote blood circulation, reduce swelling and relieve pain; Angelica dahurica can relieve the symptoms and relieve pain, reduce swelling and discharge pus, and make the heat and toxicity come out from the outside. When used together with the main drugs, the evil of heat and toxicity can be eliminated from the inside and outside. Atractylodes lancea, Magnolia officinalis, and Tangerine peel are used to dry dampness and strengthen the spleen, regulate qi and resolve phlegm, so as to stop the source of phlegm, and help qi and blood production, encourage evil to go out, and help the main and ministerial drugs; Licorice is used to clear heat and detoxify, reconcile the drugs, and alleviate the toxicity of the drugs. The combination of the drugs can play the role of clearing heat and detoxifying, reducing swelling and relieving pain.

[0033] The combination of groups A and B has a stronger efficacy, and is more effective in clearing away heat, detoxifying, dispersing blood stasis, reducing swelling and relieving pain.

[0034] The inventors also provide a method for preparing the above-mentioned Chinese medicine composition, the specific steps are as follows:

[0035] Group A: First weigh out each Chinese medicine, mix them, add water until the surface of the medicine is covered by 2-3 fingers, and soak for 1-2 hours; first boil over high heat, then simmer over low heat for 20-30 minutes, filter out the medicine liquid for later use; add water to the medicine residue again, until the surface of the medicine residue is covered by 1-2 fingers, boil over high heat, then simmer over low heat for 15-20 minutes; filter out the medicine liquid and combine it with the previous medicine liquid, simmer again over low heat for 10-15 minutes to concentrate it; filter out the concentrated medicine liquid and let it cool for later use.

[0036] Group B: First weigh out the various Chinese medicinal herbs, mix them, grind them into very fine powder, and store them in porcelain bottles for later use.

[0037] Preferably, the Chinese medicinal components in group B need to be ground into 200 mesh fine powder and stored in porcelain bottles.

[0038] When the above-mentioned Chinese medicine composition is used, according to the size of the lesion, take A liquid and B powder in a ratio of 5ml:3g, mix and stir, adjust into a paste, make the paste moderately dry and wet, have a certain plasticity, do not fall apart after grasping, and do not flow when left still, then you can get an ointment.

[0039] Generally, the dosage of A liquid is controlled at 50-100ml, and the dosage of B powder is controlled at 30-60g.

[0040] The ointment prepared above is wrapped with a single layer of gauze, spread on the affected area for external use, fixed with plastic wrap, bandage, adhesive tape, etc., left for 1 hour and then removed, twice a day. 5-7 days is a course of treatment. The symptoms of mild cases can disappear after 1 course of treatment, and the symptoms of severe cases can disappear after 2-3 courses of treatment.

[0041] The main reasons for combining component A and component B drugs are:

[0042] After long-term clinical practice, it is found that using component A liquid alone, or mixing component B powder with warm water into a paste for external use on the affected area, both have the effect of reducing swelling, relieving fever and relieving pain. However, using component A and component B drugs together and preparing them for external use using the method of the invention can achieve better therapeutic effects, which are significantly improved compared with using liquid A or powder B alone.

[0043] The Chinese medicine composition of component B is ground into extremely fine powder, preferably into 200 mesh fine powder. The main reason for storing it in a porcelain bottle is that grinding it into fine powder can better release the drug components during the application process and effectively penetrate into the skin to take effect. Many drugs in component B contain volatile oil components. Storing them in a porcelain bottle can prevent the effective volatile oil components from volatilizing to the greatest extent, resulting in weakened efficacy and drug waste.

[0044] The medicine obtained by using the above-mentioned formulation and preparation method has very significant therapeutic effect after clinical application. One course of treatment is 5-7 days. For patients with mild symptoms, the symptoms can disappear after one course of treatment, and for patients with severe symptoms, the symptoms can disappear after 2-3 courses of treatment. There are no side effects. Compared with various existing therapeutic drugs, it has very obvious advantages and fills the gap in this field.

[0045] In summary, the present invention combines the traditional Chinese medical theory with the pathogenesis that "patients with red, swollen, hot and painful skin and soft tissue lesions caused by adult gout, skin and soft tissue infection, fracture, sprain, etc. have heat and toxic accumulation and blood stasis blocking the collaterals" to provide a Chinese medicine composition for treating red, swollen, hot and painful skin and soft tissue lesions and a preparation method. The composition has the functions of clearing away heat and detoxifying, cooling blood and drying dampness, dispersing blood stasis and activating collaterals, reducing swelling and relieving pain. The combination of the medicines has significant therapeutic effect on red, swollen, hot and painful skin and soft tissue lesions. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 This is a diagram of the affected area of ​​case 1 before treatment;

[0047] Figure 2 This is a picture of the affected area of ​​Case 1 after 5 doses;

[0048] Figure 3 This is a diagram of the affected area of ​​case 2 before treatment;

[0049] Figure 4 This is a picture of the affected area in Case 2 after 5+3 doses.

[0050] Specific implementation

[0051] The present invention is not limited by the following embodiments. The following embodiments and descriptions are only for illustrating the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may be subject to various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.

[0052] Example 1

[0053] A Chinese medicine composition for treating red, swollen, hot and painful skin and soft tissue lesions caused by gout, skin and soft tissue infection, fracture, sprain, etc. in adults, comprising the following components:

[0054] Component A: 100g of Isatis root, 100g of Lycium bark, 100g of Pueraria root, 50g of Gardenia, 20g of Sophora flavescens, and 50g of Polygonum cuspidatum.

[0055] Component B: Radix Trichosanthis 100g, Phellodendron 50g, Curcuma 50g, Rhubarb 50g, Angelica dahurica 50g, Magnolia officinalis 20g, Tangerine peel 20g, Atractylodes lancea 20g, Licorice 20g.

[0056] The preparation method is as follows:

[0057] (1) Component A: First weigh out each Chinese herbal medicine, mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak it for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter out the liquid medicine for later use; add water to the residue again, until it covers the surface of the residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer it over low heat for 10-15 minutes again to concentrate it; filter out the liquid medicine, let it cool and set aside.

[0058] (2) Component B: Weigh out each Chinese herbal medicine, mix them, grind them into a very fine powder (about 200 mesh), and store them in a porcelain bottle for later use.

[0059] (3) When using, according to the size of the lesion, take 50 ml of the A liquid prepared in step (1) and 30 g of the B powder prepared in step (2), mix and stir, and adjust into a paste. The paste has a moderate degree of dryness and wetness and a certain degree of plasticity. It does not fall apart when grasped and does not flow when left still. The target drug is obtained.

[0060] When the above Chinese medicine composition is used, the target drug prepared above is wrapped with a single layer of gauze, spread on the affected area for external use, fixed with plastic wrap, bandage, adhesive tape, etc., and removed after leaving it for 1 hour. A course of treatment is 5-7 days.

[0061] Example 2

[0062] A Chinese medicine composition for treating red, swollen, hot and painful skin and soft tissue lesions caused by gout, skin and soft tissue infection, fracture, sprain, etc. in adults, prepared from the following drugs:

[0063] Component A: 120g of Isatis root, 120g of Lycium bark, 120g of Pueraria root, 80g of Gardenia, 30g of Sophora flavescens, and 80g of Polygonum cuspidatum.

[0064] Component B: Radix Trichosanthis 140g, Phellodendron 80g, Curcuma 80g, Rhubarb 80g, Angelica dahurica 80g, Magnolia officinalis 30g, Tangerine peel 30g, Atractylodes 30g, Licorice 30g.

[0065] The preparation method is as follows:

[0066] (1) Component A: First weigh out each Chinese herbal medicine, mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak it for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter out the liquid medicine for later use; add water to the residue again, until it covers the surface of the residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer it over low heat for 10-15 minutes again to concentrate it; filter out the liquid medicine, let it cool and set aside.

[0067] (2) Component B: First weigh out each Chinese herbal medicine, mix them, grind them into a very fine powder (about 200 mesh), and store them in a porcelain bottle for later use.

[0068] (3) When in use, 100 ml of the A solution prepared in step (1) and 60 g of the B powder prepared in step (2) are mixed and stirred to form a paste. The paste has a moderate degree of dryness and wetness and has a certain plasticity. It does not fall apart when grasped and does not flow when left standing. The target drug is thus obtained.

[0069] The application method is the same as that in Example 1.

[0070] Example 3

[0071] A Chinese medicine composition for treating red, swollen, hot and painful skin and soft tissue lesions caused by gout, skin and soft tissue infection, fracture, sprain, etc. in adults, prepared from the following drugs:

[0072] Component A: 110g of Isatis root, 110g of Lycium bark, 110g of Pueraria root, 60g of Gardenia, 20g of Sophora flavescens, and 60g of Polygonum cuspidatum.

[0073] Component B: Radix Trichosanthis 120g, Phellodendron 60g, Curcuma 60g, Rhubarb 60g, Angelica dahurica 60g, Magnolia officinalis 20g, Tangerine peel 20g, Atractylodes lancea 20g, Licorice 25g.

[0074] The preparation method is as follows:

[0075] (1) Component A: First weigh out each Chinese herbal medicine, mix it, add water until it covers the surface of the medicine by 2-3 fingers, and soak it for 1-2 hours; first boil it over high heat, then simmer it over low heat for 20-30 minutes, filter out the liquid medicine for later use; add water to the residue again, until it covers the surface of the residue by 1-2 fingers, boil it over high heat, then simmer it over low heat for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer it over low heat for 10-15 minutes again to concentrate it; filter out the liquid medicine, let it cool and set aside.

[0076] (2) Component B: First weigh out each Chinese herbal medicine, mix them, grind them into a very fine powder (about 200 mesh), and store them in a porcelain bottle for later use.

[0077] (3) When in use, 80 ml of the A solution prepared in step (1) and 48 g of the B powder prepared in step (2) are mixed and stirred to form a paste. The paste has a moderate degree of dryness and wetness and has a certain plasticity. It does not fall apart when grasped and does not flow when left standing. The target drug is obtained.

[0078] The application method is the same as that in Example 1.

[0079] Experimental example

[0080] 1. Clinical data

[0081] 1.1 Case source

[0082] A total of 80 patients were included in this study. All cases were from outpatient or inpatient patients in the Department of Orthopedics of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2022 to December 2023. All patients suffered from redness, swelling, heat and painful lesions of skin and soft tissue caused by gout, skin and soft tissue infections, fractures, sprains, etc.

[0083] 1.2 Diagnostic criteria

[0084] 1.2.1 Gout patients: acute severe joint pain, redness, swelling, fever. Physical examination revealed tophi. Serum uric acid levels significantly increased.

[0085] 1.2.2 Skin and soft tissue infection: Skin infection occurs after trauma or damage, with local redness, swelling, heat and pain, and may be accompanied by fever, elevated white blood cells and other infection symptoms. Common purulent skin and soft tissue infections include furuncle, carbuncle, acute cellulitis, erysipelas, etc. The specific characteristics are as follows:

[0086] Furuncles are acute bacterial suppurative inflammation of a single hair follicle and its surrounding tissues, often caused by Staphylococcus aureus, and are more common on the head, face, neck, and buttocks. In the early stages of the disease, they appear as small nodules that are red, swollen, hot, and painful. They gradually swell, and after a few days, the center becomes soft and a yellow-white pus head appears on the top. Furuncles are mostly single, but if there are a large number of them and they occur repeatedly, it is furunculosis.

[0087] Carbuncle, carbuncle is the acute suppurative inflammation that multiple adjacent hair follicles and their surrounding tissues occur simultaneously, or is formed by the fusion of multiple adjacent furuncles. Occur mostly in the neck, back and thigh where the skin is thicker, size can reach 10 centimetres or larger, initially diffuse infiltrative purpura, surface tension is shiny, tenderness is obvious, multiple pus heads appear locally afterwards, more pus plugs and bloody secretions are discharged, with tissue necrosis and ulceration, visible sinus tract, local lymphadenopathy. Clinically, the patient's conscious pulsating pain can be accompanied by systemic symptoms such as heating, fear of cold, headache, loss of appetite, and severe patients can cause death due to secondary toxemia, sepsis. Primary disease healing is slow, with scar formation.

[0088] Acute cellulitis, the lesion is red, swollen, hot, painful, and rapidly expands to the surrounding area. There is no obvious boundary between the red and swollen skin and the surrounding normal tissue, the central part is darker in color, and the surrounding part is lighter in color. If the infection site is shallow and the tissue is loose, the swelling is obvious and diffuse, and the pain is mild; if the infection site is deep or the tissue is dense, the swelling is not obvious, but the pain is severe. Patients are often accompanied by systemic symptoms of varying degrees, such as chills, fever, headache, fatigue, and increased white blood cell count. Generally, deep cellulitis, twist cellulitis caused by anaerobic bacteria and gas-producing bacteria, the systemic symptoms are more obvious, and there may be severe symptoms such as chills, high fever, convulsions, delirium, etc. The diagnosis can be made based on typical local and systemic manifestations and signs. Elevated white blood cell count, cytological examination and culture of pus are helpful for diagnosis.

[0089] Erysipelas is an infection that affects the superficial lymphatic vessels of the dermis. The main pathogen is group A beta-hemolytic streptococcus. The triggering factors are surgical wounds or fissures in the nostrils, external auditory canal, below the earlobe, anus, penis, and between the toes. Any inflammation of the skin, especially inflammation with cracks or ulcers, provides a route of invasion for pathogens. Pathogens can lurk in the lymphatic vessels and cause relapses. The incubation period is 2-5 days. Prodromal symptoms include sudden fever, chills, malaise, and nausea. Erythema appears a few hours to a day later and expands progressively with clear boundaries. The affected area is hot and tense, with nodules and non-pitting edema. The affected area is tender and burning. Enlarged proximal lymph nodes are common, with or without lymphadenitis. Pustules, blisters, or small areas of hemorrhagic necrosis may also occur. It is common in the lower legs and face. Gram staining and bacterial culture of swabs of wounds and damaged areas; blood antistreptolysin O and white blood cells; and mycological examination of dandruff can assist in diagnosis.

[0090] 1.2.3 Local redness, swelling, heat and pain caused by fracture or sprain. There is a recent history of fracture or sprain, and redness, swelling, heat and pain appear around the lesion.

[0091] 1.2.4 TCM syndrome diagnostic criteria

[0092] Syndrome of heat and toxic accumulation: local tissues are red, swollen, hot and painful, with obvious tenderness, and may be accompanied by fever, dry mouth, irritability, red face, red tongue, yellow coating, and slippery and rapid or stringy pulse.

[0093] Blood stasis and collateral obstruction syndrome: local redness and swelling, localized pain, mild tenderness, generally no fever or slight fever, dark complexion, dark tongue, ecchymosis, and sluggish pulse.

[0094] 1.3 Implementation Standards

[0095] 1.3.1 Inclusion criteria

[0096] ① Complete and reliable clinical data; ② Local lesions of redness, swelling, heat and pain caused by the above reasons; ③ Good compliance, informed consent for this experiment and objective and truthful completion of the questionnaire.

[0097] 1.3.2 Exclusion criteria

[0098] ① Large areas of skin ulceration or large wounds with heavy bleeding; ③ Pregnant or lactating women; ④ Those with contraindications or allergies to drugs; ⑤ Combined with severe dysfunction of other organs such as the liver and kidneys.

[0099] 1.3.3 Falling off and rejection criteria:

[0100] ① The patient was lost to follow-up. ② The patient withdrew on his own initiative. ③ The patient did not comply with the study protocol. ④ The patient experienced adverse events during the study.

[0101] 2. Research Methods

[0102] 2.1 Study design

[0103] The 80 patients were randomly divided into an observation group and a control group using a random number table method, with 40 cases in each group. The observation group was treated with the pharmaceutical composition of Example 1, and the control group was treated with general treatment; both the observation group and the control group were treated for 7 days, and the changes in VAS pain scores and swelling degree before and after treatment were observed in the two groups. After the treatment, all data were statistically analyzed using statistical software SPSS20.0 to compare the differences between the observation group and the control group before and after treatment.

[0104] 2.2 Treatment methods

[0105] Control group: conventional treatments for various diseases, including analgesics, anti-infective drugs, etc. Combined with ice pack cold compress or ice nitrate powder external application.

[0106] Observation Group:

[0107] The drug solution and drug powder were obtained by using the process and dosage of Example 1, mixed and stirred, and applied to the affected area twice a day, morning and evening, each time for 1 hour.

[0108] 2.3 Treatment course

[0109] Observation group and control group: treatment for 7 days.

[0110] 2.4 Observation indicators and safety evaluation standards

[0111] 2.4.1 Observation indicators

[0112] (1) Observe and compare the pain symptom scores of the two groups before and after treatment: evaluate according to the VAS pain score standard.

[0113] Pain level: ① No pain: 0 points. ② Mild pain, tolerable: 1-3 points. ③ The patient has pain and affects sleep, but can still tolerate it: 4-6 points. ④ The patient has strong pain, unbearable pain, affecting appetite and sleep: 7-10 points.

[0114] (2) Swelling degree: Based on the physician's observation, the swelling degree is divided into 4 levels, with a score of 0-3 points: Level 0: no swelling; Level 1: slight swelling; Level 2: more obvious swelling; Level 3: very severe swelling.

[0115] The above symptoms and indicators were evaluated before and after treatment.

[0116] 2.4.2 Safety evaluation criteria:

[0117] Level 1: Safe, no adverse reactions.

[0118] Level 2: Relatively safe, with mild adverse reactions, and no treatment is required and the medication can be continued.

[0119] Level 3: There are safety issues, but the adverse reactions are not serious and the medication can continue after treatment.

[0120] Level 4: There are serious safety issues and the drug cannot be used after treatment.

[0121] 2.5 Statistical methods

[0122] All data were analyzed and processed using the statistical software SPSS 20.0. All statistical tests were performed using two-sided tests, with P < 0.05 considered statistically significant and P < 0.01 considered statistically significant. During the study, all data were expressed as mean ± standard deviation. The independent sample t test was used for the comparison between groups before and after treatment, and the paired sample t test was used for the comparison within the group before and after treatment. 2 Test, rank sum test was used for rank data.

[0123] 3. Research Results

[0124] 3.1 General Information

[0125] All patients were outpatients or inpatients from the Department of Orthopedics of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2022 to December 2022, with a total of 80 cases, 40 cases in the observation group and 40 cases in the control group. No cases dropped out during the treatment of the two groups. Among them, the youngest in the observation group (17 females and 15 males) was 18 years old, the oldest was 60 years old, and the average age was 49.78±10.22 years old; the youngest in the control group (16 females and 16 males) was 19 years old, the oldest was 58 years old, and the average age was 49.12±9.88 years old. After statistical analysis and comparison, there was no statistical difference in age between the two groups (see Table 1).

[0126] Table 1 Comparison of age distribution between the two groups

[0127]

[0128] Comparison between the two age groups showed no statistically significant difference (P>0.05), indicating that the two age groups were comparable.

[0129] 3.2 Comparison of pain symptom scores between the two groups before and after treatment

[0130] Table 2 Comparison of pain symptom scores between the two groups before and after treatment

[0131]

[0132] Note: Compared with before treatment, △P<0.05, △△P<0.01; compared with the control group after treatment, ▲P<0.05, ▲▲P<0.01.

[0133] After statistical analysis, there was no significant difference in symptom scores between the two groups before treatment (P>0.05), and they were comparable. Before and after treatment, the pain symptoms in the observation group were significantly improved compared with those before treatment, and the difference was significant (P<0.01); the control group could improve the pain level (P<0.01). After treatment, the observation group was significantly better than the control group, and the statistical results of the two groups were significantly different (P<0.01) (see Table 2).

[0134] 3.3 Comparison of swelling scores between the two groups before and after treatment

[0135] Table 3 Comparison of swelling scores between the two groups before and after treatment

[0136]

[0137] Note: Compared with before treatment, △P<0.05, △△P<0.01; compared with the control group after treatment, ▲P<0.05, ▲▲P<0.01.

[0138] After statistical analysis, there was no significant difference in DLQI scores between the two groups before treatment (P>0.05), and they were comparable. In the comparison before and after treatment within the group, both the observation group and the control group improved after treatment compared with before treatment (P<0.05), and the improvement in the observation group was obvious, with significant difference (P<0.01). After treatment between the two groups, the observation group was significantly better than the control group, with significant difference (P<0.01). (See Table 3).

[0139] 3.4 Comparison of total effective rate between the two groups before and after treatment

[0140] Table 4 Comparison of total effective rate between the two groups before and after treatment

[0141]

[0142] Note: Compared with the control group, △△P<0.01.

[0143] According to statistical analysis, the total effective rate of the two groups before and after treatment was 97.5% in the observation group, and 85% in the control group. The observation group was significantly better than the control group, with a significant difference (P < 0.01) (see Table 4).

[0144] 3.5 Safety evaluation

[0145] During the study, neither group of patients experienced any drug-related discomfort symptoms nor any adverse reactions, so the safety of both groups was good, with a safety rating of Level 1.

[0146] In summary, the present invention combines the traditional Chinese medical theory with the pathogenesis that "patients with red, swollen, hot and painful skin and soft tissue lesions caused by adult gout, skin and soft tissue infection, fracture, sprain, etc. have heat and toxic accumulation and blood stasis blocking the collaterals" as the basis, and provides a Chinese medicine composition and preparation method for treating red, swollen, hot and painful skin and soft tissue lesions caused by adult gout, skin and soft tissue infection, fracture, sprain, etc. The composition can clear away heat and detoxify, cool blood and dry dampness, disperse blood stasis and activate collaterals, reduce swelling and relieve pain. The combination of the medicines has significant therapeutic effect on red, swollen, hot and painful skin and soft tissue lesions caused by adult gout, skin and soft tissue infection, fracture, sprain, etc.

[0147] Specific cases

[0148] Case 1

[0149] 2022.3.27 Liang, male, born in 1978, had redness, swelling and pain in his left big toe for 3 days. He was healthy before. 3 days ago, he developed redness, swelling and pain in his left big toe without obvious cause. The symptoms were mild at first, but gradually worsened in the past 2 days. Physical examination: The metatarsophalangeal joint of the left big toe was obviously red and swollen, bright red, and tender. He walked with a limp (such as Figure 1 (as shown). Uric acid was 768umol / L. Irritable mood, good appetite, normal sleep, yellowish urine, dry stool. Red tongue, yellow fur, stringy pulse. Diagnosis: gout.

[0150] Treatment: Use the pharmaceutical composition prepared in Example 1. When using, mix 50 ml of the drug solution in step A with 30 g of the drug powder in step B, stir and adjust to a paste, wrap it with a single layer of gauze, apply it to the affected area, and then fix it with a bandage and adhesive tape. Keep it for 1 hour and then remove it. Apply it twice a day, morning and evening. Eat a light diet, avoid spicy food, seafood, alcohol, etc., reduce the activity of the affected side, and follow up if you feel unwell.

[0151] 2022.4.2 The patient returned for a follow-up visit for left toe pain. After taking the medicine, the symptoms of redness, swelling, heat and pain basically disappeared (such as Figure 2 As shown), continue treatment, 1 dose as before (2022.3.27), guide diet, follow the previous doctor's advice, and follow up if you feel unwell.

[0152] Case 2

[0153] 2022.5.22 Ding, female, born in 1970, had redness, swelling, heat and pain in the left foot for 1 day. She had a history of hypertension, coronary heart disease, and diabetes, which was usually controlled by oral medication. Yesterday, she had redness, swelling, heat and pain in the left foot without obvious cause, and was afraid to move. Later, the pain gradually worsened, and the pain was obvious at night, and she could not fall asleep. Physical examination showed: left foot swelling, red skin, high skin temperature, obvious tenderness at the dorsum of the foot, active and passive flexion and extension of the left foot joints were limited due to pain, and the blood circulation and sensation of the toes were normal (such as Figure 3 Diagnosis: erysipelas of left foot.

[0154] Treatment: Use the pharmaceutical composition prepared in Example 2. When using, mix 100 ml of the solution in step A with 60 g of the powder in step B, stir and adjust into a paste, wrap with a single layer of gauze, apply to the affected area, and then fix with a bandage and adhesive tape. Keep it for 1 hour and then remove it. Apply twice a day, morning and evening. Eat a light diet, immobilize the affected side, and follow up if you feel unwell.

[0155] On May 27, 2022, the patient returned for a follow-up visit with redness, swelling, heat and pain in the left foot. After 5 days of medication, the patient's swelling and pain symptoms were significantly relieved, and the treatment was continued, with 3 doses as before (May 22, 2022), and moderate activities on the affected side.

[0156] On the follow-up visit on May 30, 2022, the patient's left foot had no obvious redness, swelling, heat or pain, and could move freely, with normal skin color and temperature, and no obvious tenderness (such as Figure 4 shown).

[0157] Case 3

[0158] 2022.6.15 Li, female, born in 1984, had redness and swelling on the front of the left thigh for 2 days, and had a healthy history. Two days ago, a red papule appeared on the front of the left thigh without obvious cause, and gradually became painful and expanded. It is now about 1.5 cm in diameter, with a pointed head, no pus spots, obvious tenderness, red tongue with thin yellow fur, and stringy pulse. Diagnosis: furuncle.

[0159] Treatment: Use the pharmaceutical composition prepared in Example 3. When using, mix 50 ml of the drug solution in step A with 30 g of the drug powder in step B, stir and adjust into a paste, wrap it with a single layer of gauze, apply it to the affected area, and then fix it with plastic wrap and adhesive tape. Keep it for 1 hour and then remove it. Apply it twice a day, morning and evening. Eat a light diet and follow up if you feel unwell.

[0160] Follow-up visit on June 20, 2022. The redness and swelling of the lesion subsided. Advised to eat a light diet and rest, no need to continue medication, follow-up visit if discomfort occurs.

[0161] Based on the above clinical trial results, it can be seen that the Chinese medicine composition obtained by the present invention is specifically used for treating skin redness, swelling, heat and pain-like lesions, and is mainly used to clear away heat and detoxify, cool blood and dry dampness, disperse blood stasis and activate collaterals, and reduce swelling and relieve pain. The combination of these medicines has a significant effect on reducing the inflammatory response of the affected area and alleviating local congestion, edema and pain.

Claims

1. A Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions, characterized in that: The composition consists of two components, AB, wherein the component A contains Radix Isatidis, Cortex Lycii, Radix Puerariae, Fructus Gardeniae, Radix Sophorae Flavescentis and Polygonum Cuspidati; the component B contains Radix Trichosanthis, Cortex Phellodendri, Curcuma Longa, Radix Rhei, Angelica Dahuricae, Cortex Magnoliae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae; and the components are calculated by weight as follows: Component A: 80-150 parts of Radix Isatidis, 80-150 parts of Cortex Lycii, 80-150 parts of Radix Puerariae, 40-100 parts of Gardenia, 15-50 parts of Sophora flavescens, and 40-100 parts of Polygonum cuspidatum. Component B: 80-200 parts of Radix Trichosanthis, 40-100 parts of Phellodendron, 40-100 parts of Curcuma, 40-100 parts of Rhubarb, 40-100 parts of Angelica dahurica, 15-40 parts of Magnolia officinalis, 15-40 parts of Tangerine Peel, 15-40 parts of Atractylodes, and 15-40 parts of Licorice.

2. The Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions according to claim 1, characterized in that: The component A is calculated by weight as follows: 100-120 parts of isatis root, 100-120 parts of lycium bark, 100-120 parts of kudzu root, 50-80 parts of gardenia, 20-40 parts of sophora flavescens, and 50-80 parts of polygonum cuspidatum; the component B is calculated by weight as follows: 100-150 parts of trichosanthes, 50-80 parts of phellodendron, 50-80 parts of turmeric, 50-80 parts of rhubarb, 50-80 parts of angelica dahurica, 20-30 parts of magnolia bark, 20-30 parts of tangerine peel, 20-30 parts of atractylodes, and 20-30 parts of liquorice.

3. The Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions according to claim 1 or 2, characterized in that: The A component is calculated by weight as follows: 100 parts of Isatis root, 100 parts of Lycium bark, 100 parts of Pueraria root, 50 parts of Gardenia, 20 parts of Sophora flavescens, and 50 parts of Polygonum cuspidatum; the B component is calculated by weight as follows: 100 parts of Trichosanthes kirilowii, 50 parts of Phellodendron chinense, 50 parts of Curcuma longa, 50 parts of Rhubarb, 50 parts of Angelica dahurica, 20 parts of Magnolia officinalis, 20 parts of Citrus reticulata, 20 parts of Atractylodes macrocephala, and 20 parts of Licorice.

4. The method for preparing the Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions according to claim 1, characterized in that: The specific steps are as follows: Group A: First weigh out each Chinese medicine, mix them, add water until the surface of the medicine is covered by 2-3 fingers, and soak for 1-2 hours; first boil over high heat, then simmer for 20-30 minutes, filter out the liquid medicine for later use; add water to the residue again until the surface of the residue is covered by 1-2 fingers, boil over high heat, then simmer for 15-20 minutes; after filtering out the liquid medicine, combine it with the previous liquid medicine, simmer again for 10-15 minutes for concentration; filter out the concentrated liquid medicine and let it cool for later use; Group B: First, weigh out the various Chinese medicines, mix them, grind them into very fine powder, and store them in porcelain bottles for later use; The target Chinese medicine composition is obtained by mixing liquid A and powder B in a ratio of 5 ml:3 g and adjusting them into a paste so that the paste has appropriate wetness and plasticity, does not fall apart after being grasped, and does not flow when left standing.

5. The method for preparing the Chinese medicine composition for treating skin redness, swelling, heat and pain-like lesions according to claim 4, characterized in that: The Chinese medicinal components in group B were ground into 200-mesh fine powder.

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