Composition with sleep aiding and depression preventing and treating effects and preparation method thereof

Abstract

The invention provides a composition with sleep aiding and depression prevention and treatment effects and a preparation method thereof, and relates to the technical field of medicines. The composition with the sleep aiding and depression preventing and treating effects comprises the following components in percentage by weight: 10%-20% of American ginseng, 10%-20% of spina date seeds, 10%-20% of light wheat, 10%-20% of fermented soybean, 10%-20% of lucid ganoderma, 12%-24% of lily, 10%-20% of angelica sinensis, 8%-16% of gardenia, 12%-24% of liquorice, 5%-15% of Chinese dates and 3%-9% of hericium erinaceus. By adopting cold extraction to destroy cell wall extraction stock solution, extraction is performed for 1-24 hours at the temperature of 0-4 DEG C, effective components in traditional Chinese medicinal materials can be reserved to the maximum extent, and damage of high temperature to the active components is avoided; then the extracted stock solution is diluted and boiled by adding water, so that on one hand, the components are more uniform, on the other hand, some impurities can be removed, and the purity of the product is improved; finally, the boiled liquid is cooled to 0-10 DEG C and then is filled into a sealing tank, so that the stability and the quality of the product are favorably kept, and the shelf life is prolonged.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a composition having sleep-aiding and depression-preventing and treating effects and a preparation method thereof. Background Art

[0002] In today's society, the incidence of sleep problems and depression is increasing, posing a serious threat to people's physical and mental health. With the accelerated pace of life, increased work pressure and the influence of various psychological factors, more and more people are suffering from insomnia and depression.

[0003] At present, the treatments for sleep aid and depression mainly include psychotherapy, drug therapy, etc. However, existing drug treatments have some shortcomings, such as Western medicine may cause side effects, dependence and other problems, and the treatment effect of Chinese herbal medicine alone may not be significant enough.

[0004] Therefore, in order to meet people's needs for safe, effective, and side-effect-free sleep aid and depression prevention and treatment methods, it is of great practical significance to develop a composition with sleep aid and depression prevention and treatment effects and a preparation method thereof. This composition combines a variety of Chinese medicinal materials with Western medicine ingredients, giving full play to their respective advantages and synergistic effects to achieve better therapeutic effects. At the same time, through a scientific and reasonable preparation method, the active ingredients are retained to the greatest extent, the purity and stability of the product are improved, and a new treatment option is provided for patients with insomnia and depression. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a composition with sleep-inducing and depression-preventing and treating effects and a preparation method thereof, which solves some deficiencies in existing drug treatments, including the problem that Western medicines may produce side effects and dependence, while the therapeutic effect of traditional Chinese medicines alone is not significant enough.

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme: a composition with sleep-inducing and depression-preventing effects, comprising the following ingredients in weight percentage: 10%-20% American ginseng, 10%-20% spiny jujube seeds, 10%-20% floating wheat, 10%-20% light black beans, 10%-20% ganoderma lucidum, 12%-24% lily, 10%-20% angelica, 8%-16% gardenia, 12%-24% liquorice, 5%-15% jujube and 3%-9% Hericium erinaceus.

[0007] Preferably, the American ginseng, wild jujube seeds, floating wheat, light black beans, ganoderma lucidum, lily, angelica, gardenia, liquorice, jujube and hericium erinaceus are extracted by destroying cell walls through cold extraction to obtain the original solution, which is then diluted with water and boiled.

[0008] Preferably, the composition further comprises other Chinese medicinal materials, and the other Chinese medicinal materials are selected from any one or more of ginseng, astragalus, wolfberry, chrysanthemum, Poria, Atractylodes, Codonopsis, Coptis, Phellodendron, Anemarrhena, Bupleurum, mint, tangerine peel, Pinellia, Poria and Polygala.

[0009] Preferably, the weight percentage of the other Chinese medicinal materials is 0.1%-10%.

[0010] Preferably, the composition further comprises a western medicine component, wherein the western medicine component is selected from benzodiazepines Any one or more of the following: selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, norepinephrine and specific serotonergic antidepressants.

[0011] Preferably, the weight percentage of the western medicine component is 0.1%-10%.

[0012] Preferably, a method for preparing a composition having the effects of aiding sleep and preventing and treating depression comprises the following steps:

[0013] Step 1: All Chinese medicinal materials and other selected Chinese medicinal materials are processed by cold extraction to destroy the cell walls to extract the original solution;

[0014] Step 2: dilute the extracted solution with water and boil it;

[0015] Step 3: After boiling, wait for the liquid to cool to 20-40°C and add the western medicine ingredients to ensure their activity and stability;

[0016] Step 4: Cool the boiled liquid and can it;

[0017] The preparation dosage form of the composition includes but is not limited to tablets, capsules, granules, oral liquid or injection.

[0018] Preferably, the cold extraction time in step 1 is 1-24 hours, and the extraction temperature is 0-4°C.

[0019] Preferably, the amount of water added in step 2 is 1-10 times of the original solution.

[0020] Preferably, the cooling temperature in step 4 is 0-10° C., and the canned container is a sealed can.

[0021] The present invention provides a composition having the effects of helping sleep and preventing and treating depression and a preparation method thereof. It has the following beneficial effects:

[0022] 1. The present invention uses cold extraction to destroy the cell wall to extract the stock solution, and extracts at a temperature of 0-4°C for 1-24 hours, which can retain the effective ingredients in the Chinese medicinal materials to the greatest extent and avoid the destruction of the active ingredients by high temperature; then the extracted stock solution is diluted with water and boiled, which can make the ingredients more uniform on the one hand, and on the other hand, it also helps to remove some impurities and improve the purity of the product; finally, the boiled liquid is cooled to 0-10°C and filled in a sealed can, which is conducive to maintaining the stability and quality of the product and extending the shelf life. At the same time, the prepared dosage forms include but are not limited to tablets, capsules, granules, oral solutions or injections, which can meet the needs of different patients.

[0023] 2. The composition of the present invention has a good effect on helping sleep and preventing and treating depression through the synergistic effect of multiple Chinese medicinal materials and Western medicine ingredients, providing a new treatment option for patients with insomnia and depression.

[0024] 3. The present invention provides a variety of preparation dosage forms to choose from, which is convenient for patients to use according to their own conditions and improves patient compliance.

[0025] In summary, the composition with sleep-aiding and depression-preventing and treating effects and the preparation method thereof have the beneficial effects of rich and diverse ingredients, scientific and reasonable preparation, and broad application prospects. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Embodiment 1:

[0028] The embodiment of the present invention provides a composition with sleep-inducing and depression-preventing effects, comprising the following ingredients in percentage by weight: 10% American ginseng, 10% sour jujube seeds, 10% floating wheat, 10% light black beans, 10% ganoderma lucidum, 12% lily, 10% angelica, 8% gardenia, 12% liquorice, 5% jujube and 3% hericium erinaceus; American ginseng, sour jujube seeds, floating wheat, light black beans, ganoderma lucidum, lily, angelica, gardenia, liquorice, jujube and hericium erinaceus are obtained by extracting the original solution by destroying the cell wall through cold extraction, and then diluting with water and boiling.

[0029] The composition also contains other Chinese medicinal materials, which are selected from any one or more of ginseng, astragalus, wolfberry, chrysanthemum, poria, atractylodes, codonopsis, coptis, phellodendron, anemarrhena, bupleurum, mint, tangerine peel, pinellia, poria and polygala; the weight percentage of other Chinese medicinal materials is 0.1%.

[0030] The composition further comprises a western medicine component, wherein the western medicine component is selected from benzodiazepine Any one or more of the following: selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, norepinephrine and specific serotonin antidepressants; the weight percentage of the western medicine component is 0.1%.

[0031] The synergistic effect of various Chinese medicinal materials, among which American ginseng can replenish qi and nourish yin, clear away heat and promote the production of body fluid, help relieve fatigue and improve physical condition; Chinese date seeds have the effects of nourishing the heart and calming the mind, and astringing sweat, which has a good improvement effect on insomnia; floating wheat can replenish qi, remove heat, and stop sweating, which can relieve the symptoms of excessive sweating caused by anxiety; light fermented black beans can relieve the symptoms, eliminate restlessness, and release stagnation and heat, which can help soothe emotions; Ganoderma lucidum can replenish qi and calm the mind, relieve cough and asthma, and enhance the body's immunity; lily can moisten the lungs and relieve cough, clear the heart and calm the mind, and have a certain effect on relieving emotional irritability; angelica can replenish blood and activate blood circulation, regulate menstruation and relieve pain, and can improve the body's qi and blood circulation; gardenia can purge fire and eliminate restlessness, clear heat and dampness, and help clear dryness and heat in the body; licorice harmonizes various medicines, and has the effects of replenishing spleen and replenishing qi, clearing heat and detoxifying; jujube can replenish qi, nourish blood and calm the mind, and can enhance the body's resistance; Hericium erinaceus can aid digestion, benefit the spleen and stomach, and is beneficial to the overall health of the body. These Chinese medicinal materials cooperate with each other to play the role of helping sleep and preventing and treating depression. Flexible selection of other Chinese medicinal materials: Ginseng, astragalus, wolfberry and other Chinese medicinal materials can be selected and added, and can be personalized according to the specific conditions of different patients to improve the pertinence and effectiveness of treatment. For example, ginseng replenishes vital energy, astragalus replenishes qi and raises yang, wolfberry nourishes the liver and kidneys, chrysanthemum clears the liver and improves eyesight, etc., which can be combined according to different constitutions and symptoms. Western medicine ingredients such as benzodiazepines Drugs such as 5-HT reuptake inhibitors and selective serotonin reuptake inhibitors have clear antidepressant and sleep-inducing effects. When used in combination with Chinese medicinal materials, they can give full play to the advantages of combining Chinese and Western medicine. On the one hand, Western medicine can quickly relieve symptoms, and on the other hand, Chinese medicinal materials can regulate the body as a whole, reduce the side effects of Western medicine, and improve patient compliance.

[0032] A method for preparing a composition having the effects of aiding sleep and preventing and treating depression comprises the following steps:

[0033] Step 1: All Chinese medicinal materials and other selected Chinese medicinal materials are treated by cold extraction to destroy the cell walls to extract the original solution; the cold extraction time in step 1 is 1 hour, and the extraction temperature is 0°C;

[0034] Step 2: dilute the extracted stock solution with water and boil it; the amount of water added in step 2 is 1 times the amount of the stock solution;

[0035] Step 3: After boiling, wait for the liquid to cool to 20°C and add the western medicine ingredients to ensure their activity and stability;

[0036] Step 4: Cool the boiled liquid and then can it; the cooling temperature in step 4 is 0°C, and the canning container is a sealed can;

[0037] The preparation dosage form of the composition includes but is not limited to tablets, capsules, granules, oral liquid or injection solution.

[0038] Cold extraction at a low temperature of 0°C for 1 hour can retain the effective ingredients of Chinese medicinal materials to the greatest extent and avoid the damage of active ingredients by high temperature. At the same time, the method of extracting the stock solution by destroying the cell wall can improve the extraction rate of effective ingredients and enhance the efficacy of the composition; diluting and boiling the stock solution with water can, on the one hand, make the ingredients of Chinese medicinal materials more evenly distributed in the solution, and on the other hand, it can also play a role in sterilization and disinfection to ensure the safety of the product. The amount of water added is 1 times the stock solution, which can be adjusted according to different dosage forms and needs, with high flexibility; adding Western medicine ingredients after the liquid is cooled to 20°C can ensure the activity and stability of Western medicine. This temperature range will not damage the Western medicine ingredients, but can also make them fully dissolved in the solution to achieve the best therapeutic effect; cooling the boiled liquid to 0°C and filling it in a sealed can can extend the shelf life of the product and prevent oxidation and deterioration of the effective ingredients. The use of sealed cans can ensure the hygiene and safety of the product and avoid contamination by external factors. In addition, the preparation dosage form of the composition includes tablets, capsules, granules, oral liquid or injection, etc., which meets the needs of different patients. Patients can choose the dosage form suitable for them according to their preferences and convenience of use, thereby improving treatment compliance.

[0039] Embodiment 2:

[0040] The embodiment of the present invention provides a composition with sleep-inducing and depression-preventing effects, comprising the following ingredients in percentage by weight: 20% American ginseng, 20% sour jujube kernel, 20% floating wheat, 20% light fermented black beans, 20% ganoderma lucidum, 24% lily, 20% angelica, 16% gardenia, 24% liquorice, 15% jujube and 9% hericium erinaceus; American ginseng, sour jujube kernel, floating wheat, light fermented black beans, ganoderma lucidum, lily, angelica, gardenia, liquorice, jujube and hericium erinaceus are obtained by extracting the original solution by destroying the cell wall through cold extraction, and then diluting with water and boiling.

[0041] The composition also contains other Chinese medicinal materials, which are selected from any one or more of ginseng, astragalus, wolfberry, chrysanthemum, poria, atractylodes, codonopsis, coptis, phellodendron, anemarrhena, bupleurum, mint, tangerine peel, pinellia, poria and polygala; the weight percentage of other Chinese medicinal materials is 10%.

[0042] The composition further comprises a western medicine component, wherein the western medicine component is selected from benzodiazepine Any one or more of the following: selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, norepinephrine and specific serotonin antidepressants; the weight percentage of the western medicine component is 10%.

[0043] The synergistic effect of various Chinese medicinal materials, among which American ginseng can replenish qi and nourish yin, clear away heat and promote the production of body fluid, help relieve fatigue and improve physical condition; Chinese date seeds have the effects of nourishing the heart and calming the mind, and astringing sweat, which has a good improvement effect on insomnia; floating wheat can replenish qi, remove heat, and stop sweating, which can relieve the symptoms of excessive sweating caused by anxiety; light fermented black beans can relieve the symptoms, eliminate restlessness, and release stagnation and heat, which can help soothe emotions; Ganoderma lucidum can replenish qi and calm the mind, relieve cough and asthma, and enhance the body's immunity; lily can moisten the lungs and relieve cough, clear the heart and calm the mind, and have a certain effect on relieving emotional irritability; angelica can replenish blood and activate blood circulation, regulate menstruation and relieve pain, and can improve the body's qi and blood circulation; gardenia can purge fire and eliminate restlessness, clear heat and dampness, and help clear dryness and heat in the body; licorice harmonizes various medicines, and has the effects of replenishing spleen and replenishing qi, clearing heat and detoxifying; jujube can replenish qi, nourish blood and calm the mind, and can enhance the body's resistance; Hericium erinaceus can aid digestion, benefit the spleen and stomach, and is beneficial to the overall health of the body. These Chinese medicinal materials cooperate with each other to play the role of helping sleep and preventing and treating depression. Flexible selection of other Chinese medicinal materials: Ginseng, astragalus, wolfberry and other Chinese medicinal materials can be selected and added, and can be personalized according to the specific conditions of different patients to improve the pertinence and effectiveness of treatment. For example, ginseng replenishes vital energy, astragalus replenishes qi and raises yang, wolfberry nourishes the liver and kidneys, chrysanthemum clears the liver and improves eyesight, etc., which can be combined according to different constitutions and symptoms. Western medicine ingredients such as benzodiazepines Drugs such as 5-HT reuptake inhibitors and selective serotonin reuptake inhibitors have clear antidepressant and sleep-inducing effects. When used in combination with Chinese medicinal materials, they can give full play to the advantages of combining Chinese and Western medicine. On the one hand, Western medicine can quickly relieve symptoms, and on the other hand, Chinese medicinal materials can regulate the body as a whole, reduce the side effects of Western medicine, and improve patient compliance.

[0044] A method for preparing a composition having the effects of aiding sleep and preventing and treating depression comprises the following steps:

[0045] Step 1: All Chinese medicinal materials and other selected Chinese medicinal materials are treated by cold extraction to destroy the cell walls to extract the original solution; the cold extraction time in step 1 is 24 hours and the extraction temperature is 4°C;

[0046] Step 2: dilute the extracted stock solution with water and boil it; the amount of water added in step 2 is 10 times that of the stock solution;

[0047] Step 3: After boiling, wait for the liquid to cool to 40°C and add the western medicine ingredients to ensure their activity and stability;

[0048] Step 4: Cool the boiled liquid and then can it; the cooling temperature in step 4 is 10°C, and the canning container is a sealed can;

[0049] The preparation dosage form of the composition includes but is not limited to tablets, capsules, granules, oral liquid or injection solution.

[0050] Cold extraction at a low temperature of 4°C for 24 hours can retain the effective ingredients of Chinese medicinal materials to the greatest extent and avoid the damage of active ingredients by high temperature. At the same time, the method of extracting the stock solution by destroying the cell wall can improve the extraction rate of effective ingredients and enhance the efficacy of the composition; diluting and boiling the stock solution with water can, on the one hand, make the ingredients of Chinese medicinal materials more evenly distributed in the solution, and on the other hand, it can also play a role in sterilization and disinfection to ensure the safety of the product. The amount of water added is 10 times that of the stock solution, which can be adjusted according to different dosage forms and needs, with high flexibility; adding Western medicine ingredients after the liquid is cooled to 40°C can ensure the activity and stability of Western medicine. This temperature range will not damage the Western medicine ingredients, but can also make them fully dissolved in the solution to exert the best therapeutic effect; after the boiled liquid is cooled to 10°C and filled in a sealed can, the shelf life of the product can be extended to prevent oxidation and deterioration of the effective ingredients. The use of sealed cans can ensure the hygiene and safety of the product and avoid contamination by external factors. In addition, the preparation dosage form of the composition includes tablets, capsules, granules, oral liquid or injection, etc., which meets the needs of different patients. Patients can choose the dosage form suitable for them according to their preferences and convenience of use, thereby improving treatment compliance.

[0051] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composition having the effects of helping sleep and preventing and treating depression, characterized in that: The invention comprises the following ingredients in weight percentage: American ginseng 10%-20%, spiny jujube kernel 10%-20%, floating wheat 10%-20%, light black bean 10%-20%, ganoderma lucidum 10%-20%, lily 12%-24%, angelica 10%-20%, gardenia 8%-16%, liquorice 12%-24%, jujube 5%-15% and hericium erinaceus 3%-9%.

2. A composition having sleep-aiding and depression-preventing effects according to claim 1, characterized in that: The American ginseng, sour jujube seeds, floating wheat, light black beans, ganoderma lucidum, lily, angelica, gardenia, liquorice, jujube and hericium erinaceus are extracted by destroying cell walls through cold extraction to obtain the original solution, which is then diluted with water and boiled.

3. A composition having sleep-aiding and depression-preventing effects according to claim 1, characterized in that: The composition further comprises other Chinese medicinal materials, which are selected from any one or more of ginseng, astragalus, wolfberry, chrysanthemum, Poria, Atractylodes macrocephala, Codonopsis pilosula, Coptis chinensis, Phellodendron amurense, Anemarrhena asphodeloides, Bupleurum chinense, mint, tangerine peel, Pinellia ternata, Poria and Polygala tenuifolia.

4. A composition having sleep-aiding and depression-preventing effects according to claim 3, characterized in that: The weight percentage of the other Chinese medicinal materials is 0.1%-10%.

5. A composition having sleep-aiding and depression-preventing effects according to claim 1 or 2, characterized in that: The composition further comprises a western medicine component, wherein the western medicine component is selected from benzodiazepines Any one or more of the following: selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, norepinephrine and specific serotonergic antidepressants.

6. A composition having the effects of aiding sleep and preventing and treating depression according to claim 5, characterized in that: The weight percentage of the western medicine component is 0.1%-10%.

7. A method for preparing a composition having sleep-aiding and depression-preventing effects according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1: All Chinese medicinal materials and other selected Chinese medicinal materials are processed by cold extraction to destroy the cell walls to extract the original solution; Step 2: dilute the extracted solution with water and boil it; Step 3: After boiling, wait for the liquid to cool to 20-40°C and add the western medicine ingredients to ensure their activity and stability; Step 4: Cool the boiled liquid and can it; The preparation dosage form of the composition includes but is not limited to tablets, capsules, granules, oral liquid or injection.

8. The method for preparing a composition having the effects of aiding sleep and preventing and treating depression according to claim 7, characterized in that: The cold extraction time in step 1 is 1-24 hours, and the extraction temperature is 0-4°C.

9. The method for preparing a composition having the effects of aiding sleep and preventing and treating depression according to claim 7, characterized in that: The amount of water added in step 2 is 1-10 times of the original solution.

10. The method for preparing a composition having the effects of aiding sleep and preventing and treating depression according to claim 7, characterized in that: The cooling temperature in the step 4 is 0-10° C., and the canned container is a sealed can.