Fluid distributor for chromatographic column and distribution assembly thereof

Abstract

The invention provides a fluid distributor for a chromatographic column and a distribution assembly thereof, the fluid distributor comprises a plate body, the center position of the plate body is provided with a center flow channel for liquid phase to enter and exit, the plate body is provided with flow dividing grooves formed by flow dividing ribs, and the flow dividing ribs are distributed in a radial direction, and the flow dividing grooves are distributed from a center flow channel opening to the edge of the plate body in a radial manner; the diversion grooves formed by the middle flow ribs are distributed from the center flow channel opening to the edge of the plate body in a radial mode, the distribution speed of a liquid phase can be increased, and efficiency is improved.

Description

Technical Field

[0001] The invention relates to a biomedical downstream chromatographic column, and in particular to a chromatographic column fluid distributor and a distribution component thereof. Background Art

[0002] Chromatographic columns are used for separation and purification of downstream biopharmaceuticals, so the liquid phase product needs to be evenly distributed on the surface of the column bed and then flow downward synchronously, which requires continuity, uniformity, stability and tightness. Therefore, there are strict requirements for the liquid phase distribution components of the chromatographic column. In the prior art, the diverter plate is a diverter groove separated by continuous diverter ribs that diverge from the center of the distributor to the circumferential direction. Therefore, its disadvantage is that congestion of liquid on any diverter groove (for example, there are bubbles in the diverter groove) will cause the liquid that diverges outward from the entire diverter groove to be unable to flow, resulting in a poor distribution effect.

[0003] Prior patent publication number: CN1856346A invention name: chromatographic column distribution system, the distributor of which is a diversion slot divided by the above-mentioned continuous emission ribs, which will cause bubble embolism problem. Summary of the invention

[0004] In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a chromatographic column fluid distributor and a distribution component thereof, which replans the distribution of the diversion slots to improve the flow distribution efficiency of the liquid phase.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] In response to the above technical problems, the first aspect of the present invention discloses a fluid distributor for a chromatographic column, comprising a plate body, a central flow channel for liquid to enter and exit at the center of the plate body, a diversion groove formed by diversion ribs is arranged on the plate body, the diversion ribs are along the radial direction, and the diversion grooves are distributed in an radiating shape from the central flow channel opening toward the edge of the plate body.

[0007] In some embodiments, the diverter ribs are evenly distributed on the plate in the form of concentric circles.

[0008] In some embodiments, the diverter ribs on the same concentric circle have the same length.

[0009] In some embodiments, the length of the diverter ribs in the inner circle is less than or equal to that in the outer circle.

[0010] In some embodiments, the number of diverter ribs on each concentric circle is greater than or equal to that on the inner circle.

[0011] In some embodiments, each of the diverter ribs on the two adjacent concentric circles are not in the same radial direction.

[0012] In some embodiments, each of the diverter ribs on the inner ring is located in the middle between two diverter ribs on the outer ring.

[0013] In some embodiments, there are gaps between the diverter ribs on the same concentric circle and the diverter ribs on different inner and outer concentric circles.

[0014] In some embodiments, a groove is provided at the edge of the plate body for placing a sealing ring.

[0015] In some embodiments, a connecting hole is provided in the plate body groove for connecting the screen plate.

[0016] In response to the above technical problems, the first aspect of the present invention discloses a chromatographic column fluid distribution component, including the distributor described above, wherein the plate body of the distributor is a column flange or a column piston, and a screen plate is provided on one side of the plate body having a diversion groove, and the plate body and the screen plate are detachably fixedly connected.

[0017] Beneficial effects:

[0018] The present invention directly adopts the diverter groove formed by the mid-flow rib, and the diverter groove is distributed in a radial shape from the central flow channel opening to the edge of the plate body, which can increase the distribution speed of the liquid phase and improve the efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a top view of the fluid dispenser of the present invention.

[0020] Figure 2 It is a partial cross-sectional view of a distribution assembly of the present invention. DETAILED DESCRIPTION

[0021] The present invention will be further described below in conjunction with the accompanying drawings.

[0022] The technical content of the present invention is described below by specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. Those skilled in the art can make various modifications and changes without departing from the spirit of the present invention.

[0023] Before describing the specific embodiments of the present disclosure in detail, some terms used in the present disclosure are first explained.

[0024] Unless otherwise defined below, the meaning of all technical terms and scientific terms used herein is intended to be the same as those commonly understood by those skilled in the art. Mentioning the technology used in this article is intended to refer to the technology commonly understood in the art, including those changes in technology that are obvious to those skilled in the art or the replacement of equivalent technology. Although it is believed that the following terms are well understood by those skilled in the art, the following definitions are still set forth to better explain the present invention. When a trade name appears in this article, it is intended to refer to the corresponding commodity. All patents, published patent applications and publications cited herein are incorporated herein by reference.

[0025] Unless otherwise indicated herein, multiple references such as "a", "the", include plural references. The expression "one or more" or "at least one" may mean 1, 2, 3, 4, 5, 6, 7, 8, 9 or more.

[0026] As used herein, the terms “connected”, “connected”, “coupled” or “coupled” and the like are not limited to direct connections but also include indirect connections.

[0027] As used herein, the "liquid phase" refers to biomolecules, including proteins, nucleic acids, lipids, carbohydrates, small nucleotides, amino acids and their derivatives.

[0028] The position relationship words "up", "down", "left", "right", "front", "back", etc. involved in this article are determined according to the layout direction of the drawings in the specification. They are only used to indicate relative position relationships. When the absolute position of the object being described changes, the relative position relationship may also change accordingly.

[0029] The application scenario of the present invention is low-pressure chromatography.

[0030] Reference Figure 1As shown, a fluid distributor for a chromatographic column includes a plate body 1, wherein the center of the plate body 1 has a central flow channel 2 for allowing the liquid phase to enter and exit, and the plate body 1 is provided with diverter ribs 3, which form diverter grooves 4, and the diverter grooves 4 are distributed in an radiating shape from the central flow channel opening to the edge of the plate body, that is, each separation groove 4 is in an inverted trapezoidal structure, and the caliber of one end is larger than the caliber of the other end. The diverter ribs 3 are evenly distributed on the plate body 1, and the diverter ribs 3 surround the flow channel opening of the central flow channel 2 in a concentric circle manner. It can be seen from the figure that the concentric circles are composed of three circles of diverter ribs 3. The lengths of the diverter ribs 3 on the same concentric circle are the same. The length of the diverter ribs 3 on the inner circle is less than or equal to the diverter ribs 3 on the outer circle. It can be seen from the figure that the length of the diverter ribs 3 on the inner circle is less than that on the outer circle, and gradually increases from the inside to the outside. The positions of the diverter ribs on adjacent concentric circles cannot be aligned with each other, and need to be evenly staggered, that is, each diverter rib 3 on two adjacent concentric circles is not in the same radial direction. As shown in the figure, each diverter rib 3 on the inner circle is located in the middle position between the two diverter ribs 3 on the outer circle. There is the same gap between the diverter ribs 3 on the same concentric circle, and there is the same gap between the diverter ribs 3 on different inner and outer concentric circles. A groove 5 is provided at the edge of the plate body 1 for placing a sealing ring, and a connecting hole 6 is provided in the groove 5 for connecting the screen plate by bolts.

[0031] Reference Figure 2 The fluid distribution component for a chromatographic column shown in the figure includes the distributor described above, wherein the plate body 1 of the distributor is a column flange or a column piston, and a screen plate 7 is arranged on one side of the plate body 1 having a diversion groove, and the plate body and the screen plate are detachably fixedly connected.

[0032] In the present invention, the flow dividing ribs are distributed in concentric circles according to the diameter of the plate body 1. The smaller the diameter of the plate body, the fewer the number of concentric circles, and the larger the diameter, the more the number of concentric circles. Therefore, the specific embodiments described above further describe the technical problems, technical solutions and beneficial effects solved by the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A fluid distributor for a chromatographic column, characterized in that: It includes a plate body, a central flow channel for liquid phase to enter and exit is provided at the center of the plate body, a diversion groove formed by diversion ribs is arranged on the plate body, the diversion ribs are along the radial direction, and the diversion grooves are distributed in a radial shape from the central flow channel opening to the edge of the plate body.

2. A chromatographic column fluid distributor according to claim 1, characterized in that: The diverter ribs are evenly distributed on the plate body in a concentric circle distribution manner.

3. A chromatographic column fluid distributor according to claim 2, characterized in that: The lengths of the diverter ribs on the same concentric circle are the same.

4. A chromatographic column fluid distributor according to claim 2, characterized in that ,, the length of the diverter rib in the inner circle is less than or equal to that in the outer circle.

5. A fluid distributor for a chromatographic column according to claim 2, characterized in that: The number of the diverter ribs on each concentric circle is greater than or equal to that of the inner circle.

6. A fluid distributor for a chromatographic column according to claim 2, characterized in that: Each of the flow dividing ribs on the two adjacent concentric circles is not in the same radial direction.

7. A fluid distributor for a chromatography column according to claim 6, characterized in that: Each of the flow-dividing ribs on the inner ring is located at the middle position between the two flow-dividing ribs on the outer ring.

8. A fluid distributor for a chromatography column according to claim 2, characterized in that: There are gaps between the diverter ribs on the same concentric circle and the diverter ribs on different inner and outer concentric circles.

9. A fluid distributor for a chromatography column according to claim 1, characterized in that: A groove is arranged at the edge of the plate body for placing a sealing ring; a connecting hole is arranged in the groove of the plate body for connecting the screen plate.

10. A fluid distribution assembly for a chromatographic column, characterized in that: Including the distributor described above, the plate body of the distributor is a column flange or a column piston, a screen plate is arranged on the side of the plate body with the diversion groove, and the plate body and the screen plate are detachably fixedly connected.

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