Sample analyzer

Abstract

The embodiment of the invention provides a sample analyzer which comprises a pipetting needle and an ultrasonic cleaning device, the ultrasonic cleaning device comprises an ultrasonic generator and a cleaning pool, and the ultrasonic generator comprises an ultrasonic transducer and a vibration part which are connected with each other; the cleaning pool is made of plastic and comprises a liquid storage cavity used for containing cleaning liquid, an opening is formed in the top side of the liquid storage cavity, a mounting opening is formed in the side wall of the liquid storage cavity, and the vibration end, away from the ultrasonic transducer, of the vibration part penetrates through the mounting opening in a sealed mode and is inserted into the liquid storage cavity. In the embodiment of the invention, the vibration part hermetically penetrates through the mounting opening and is inserted into the liquid storage cavity, so that the vibration part can be completely or mostly immersed in the cleaning liquid, and the fogging phenomenon at the liquid level of the cleaning liquid in the related technology is improved; the vibration part directly transmits ultrasonic vibration to the cleaning liquid, the requirements for fatigue resistance and structural strength of the pool wall are lowered, the plastic material is not prone to generating noise in the ultrasonic vibration process, and the noise of the cleaning pool in the cleaning process can be effectively lowered.

Description

Technical Field

[0001] The present application relates to the field of in vitro diagnostic medical technology, and in particular to a sample analyzer. Background Art

[0002] In the related art, the sample analyzer is equipped with an ultrasonic cleaning tank and an ultrasonic generator. The ultrasonic generator transmits vibration to the wall of the ultrasonic cleaning tank, and the vibration of the wall is transmitted to the cleaning liquid in the cleaning tank. In order to achieve a better vibration-initiating effect, the wall of the tank is generally a thin-walled structure, and the thin-walled structure is prone to fatigue and cracking after long-term work; in addition, the wall of the tank serves as an ultrasonic emitting surface, and it is easy to fog on the surface of the cleaning liquid. The vibration of the part of the wall that is not in contact with the cleaning liquid is invalid vibration, resulting in a low ultrasonic power density. More energy is required to meet the cleaning effect. Summary of the invention

[0003] In view of this, the embodiments of the present application hope to provide a sample analyzer to solve at least one of the above-mentioned technical problems.

[0004] The present application embodiment provides a sample analyzer, comprising:

[0005] The dispensing mechanism comprises a moving part and a pipette needle arranged on the moving part; the moving part is used to drive the pipette needle to move between different operation positions to absorb or discharge a target liquid, wherein the target liquid comprises at least one of a sample or a reagent;

[0006] An ultrasonic cleaning device comprises an ultrasonic generator and a cleaning tank, wherein the ultrasonic generator comprises an ultrasonic transducer and a vibrating part connected to each other; the cleaning tank is made of plastic, and comprises a liquid storage cavity for accommodating a cleaning liquid, wherein the top side of the liquid storage cavity has an opening, and the side wall of the liquid storage cavity is provided with a mounting opening, and the vibrating end of the vibrating part away from the ultrasonic transducer is sealedly passed through the mounting opening and inserted into the liquid storage cavity,

[0007] A liquid circuit support mechanism, the liquid circuit support mechanism is used to provide cleaning liquid to the liquid storage chamber;

[0008] The moving component is also used to drive the pipette needle to move from the opening into the cleaning liquid in the liquid storage chamber, and the vibrating part is used to transmit the ultrasonic vibration of the ultrasonic transducer to the cleaning liquid to ultrasonically clean the pipette needle through the cleaning liquid.

[0009] In the embodiment of the present application, the side wall of the liquid storage cavity is provided with an installation opening, and the vibration part is sealed through the installation opening and inserted into the liquid storage cavity. In other words, the vibration part will not be inserted into the liquid storage cavity from the opening, so it is conducive to completely or mostly immersing the vibration part in the cleaning liquid, improving the fogging phenomenon at the liquid surface of the cleaning liquid in the related art; the vibration part directly transmits the ultrasonic vibration to the cleaning liquid, and there is no need to ultrasonically vibrate the pool wall of the cleaning pool, so it can improve the stress condition of the pool wall of the cleaning pool, reduce the requirements for the fatigue strength and structural strength of the pool wall, and in addition, the input-output conversion efficiency of the ultrasonic wave is higher; the plastic material is not easy to generate noise during ultrasonic vibration, which can effectively reduce the noise of the cleaning pool during cleaning.

[0010] The present application embodiment provides a sample analyzer, comprising:

[0011] The dispensing mechanism comprises a moving part and a pipette needle arranged on the moving part; the moving part is used to drive the pipette needle to move between different operation positions to absorb or discharge a target liquid, wherein the target liquid comprises at least one of a sample or a reagent;

[0012] An ultrasonic cleaning device comprises an ultrasonic generator and a cleaning tank, wherein the ultrasonic generator comprises an ultrasonic transducer and a vibration part connected to each other;

[0013] The cleaning tank comprises a liquid storage cavity for containing cleaning liquid, the top side of the liquid storage cavity has an opening, the material of the cleaning tank comprises plastic, the vibrating part extends into the liquid storage cavity, and any part thereof does not exceed the liquid level of the liquid storage cavity when overflow occurs;

[0014] A liquid circuit support mechanism, the liquid circuit support mechanism is used to provide cleaning liquid to the liquid storage chamber;

[0015] The moving component is also used to drive the pipette needle to move from the opening into the cleaning liquid in the liquid storage chamber, and the vibrating part is used to transmit the ultrasonic vibration of the ultrasonic transducer to the cleaning liquid to ultrasonically clean the pipette needle through the cleaning liquid.

[0016] In the sample analyzer of this embodiment, the liquid level at overflow is the designed maximum liquid level of the liquid storage chamber, that is, the theoretical maximum value of the liquid level in the liquid storage chamber is the liquid level at overflow. It should be noted that during actual use, the liquid level in the liquid storage chamber can be at the level at overflow, or it can be lower than the level at overflow. In this embodiment, the vibrating part can be basically completely submerged in the cleaning liquid, which can further improve or avoid the phenomenon of fogging on the liquid surface; the plastic material is not easy to produce noise during ultrasonic vibration, which can effectively reduce the noise of the cleaning pool during cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1A simplified schematic diagram of a sample analyzer according to an embodiment of the present application;

[0018] Figure 2 A schematic diagram of an ultrasonic cleaning device and a pipette needle according to an embodiment of the present application;

[0019] Figure 3 A schematic diagram of an ultrasonic cleaning device according to another embodiment of the present application;

[0020] Figure 4 A schematic diagram of an ultrasonic cleaning device according to another embodiment of the present application;

[0021] Figure 5 This is a schematic diagram of an ultrasonic cleaning device according to another embodiment of the present application;

[0022] Figure 6 FIG. 1 is a schematic diagram of an ultrasonic generator according to an embodiment of the present application.

[0023] Description of Reference Numerals

[0024] Sample unit 11; sample dispensing mechanism 12; reagent unit 13; reagent dispensing mechanism 14; mixing mechanism 15; reaction component 16; light measuring component 17;

[0025] Ultrasonic cleaning device 200;

[0026] Ultrasonic generator 21; ultrasonic transducer 211; convex ring 2111; vibration part 212; end surface 212a of the vibration end; cut surface 212b; arc surface 212c;

[0027] Cleaning tank 22; liquid storage chamber 221; liquid discharge port 221a; first bottom wall 2215; second bottom wall 2214; first overflow chamber 222; second overflow chamber 223; outlets 222a, 223a; first side wall 2211; second side wall 2212; third side wall 2213; notch 221c; first sealing ring 231; second sealing ring 232; flange 233; screw 24; pipette needle 4 DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0029] The various specific technical features described in the specific embodiments can be combined in any suitable manner without contradiction, for example, different embodiments and technical solutions can be formed by combining different specific technical features. In order to avoid unnecessary repetition, various possible combinations of the specific technical features in the present invention will not be described separately.

[0030] In the following description, the terms "first\second\..." are only used to distinguish different objects, and do not mean that the objects have the same or related points. It should be understood that the directions "above", "below", "outside" and "inside" are all directions in normal use, and the directions "left" and "right" refer to the left and right directions shown in the specific corresponding schematic diagrams, which may be the left and right directions in normal use or not.

[0031] It should be noted that the terms "comprises", "includes" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also includes other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element. "Multiple" means greater than or equal to two.

[0032] An embodiment of the present application provides a sample analyzer.

[0033] The specific type of the sample analyzer is not limited, for example, it can be an immunoassay analyzer, a biochemistry analyzer, a coagulation analyzer, a blood rheology analyzer, etc.

[0034] Before describing the present invention in detail, the structure of a sample analyzer is first described as an example.

[0035] See also Figure 1 The sample analyzer may include a sample unit 11, a sample dispensing mechanism 12, a reagent unit 13, a reagent dispensing mechanism 14, a mixing mechanism 15, a reaction component 16, and a light measuring component 17.

[0036] The sample unit 11 is used to carry samples. The sample unit 11 may be a sample tray, which includes a plurality of sample positions such as sample tubes, and the sample tray can be arranged to corresponding positions by rotating its tray structure, for example, a position for the sample dispensing mechanism 12 to absorb the sample.

[0037] The sample dispensing mechanism 12 is used to absorb the sample and discharge it into the reaction cup to be loaded with the sample. The sample dispensing mechanism 12 is equipped with a sample needle, which moves to absorb the sample carried by the sample unit 11, moves to the reaction cup to be loaded with the sample, and discharges the sample into the reaction cup.

[0038] The reagent unit 13 is used to carry the reagent. In one embodiment, the reagent unit 13 may be a reagent disk, which is a disk-shaped structure with multiple positions for carrying reagent containers. The reagent unit 13 can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container to a specific position, such as a position where the reagent is sucked by the reagent dispensing mechanism 14. The number of the reagent units 13 may be one or more.

[0039] The reagent dispensing mechanism 14 is used to absorb the reagent and discharge it into the reaction cup to be added with the reagent. The reagent dispensing mechanism 14 is equipped with a reagent needle, which moves to absorb the reagent carried by the reagent unit 13, moves to the reaction cup to be added with the reagent, and discharges the reagent into the reaction cup.

[0040] The mixing mechanism 15 is used to mix the reaction liquid in the reaction cup. Exemplarily, the mixing mechanism 15 is configured with a stirring rod, which is used to mix and stir the reaction liquid in the reaction cup.

[0041] The number of the mixing mechanism 15 can be one or more.

[0042] The reaction component 16 has at least one placement position, and the placement position is used to place the reaction cup and incubate the reaction liquid in the reaction cup. For example, the reaction component 16 can be a reaction disk, which is arranged in a disc-shaped structure and has one or more placement positions for placing the reaction cup. The reaction disk can rotate and drive the reaction cup in its placement position to rotate, so as to arrange the reaction cup in the reaction disk and incubate the reaction liquid in the reaction cup.

[0043] The light measuring component 17 is used to perform light measurement on the reaction solution after incubation to obtain the reaction data of the sample. For example, the light measuring component 17 detects the luminous intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample through the calibration curve. In one embodiment, the light measuring component 17 is separately arranged outside the reaction component 16.

[0044] It should be noted that the optical measurement analysis may be immunoassay, biochemical analysis, coagulation analysis, blood rheology analysis, and the like.

[0045] The specific type of the sample is not limited, and can be body fluids such as serum, blood, plasma, spinal fluid, urine, gastric juice, intestinal fluid, bile, saliva, tears, or solutions from organisms such as cell extracts, or solutions used in medical treatment such as dialysate, infusion, nutrients, and medicines.

[0046] For example, to avoid cross contamination of samples / reagents, the sample needle / reagent needle should be cleaned after sampling and adding. The next sampling and adding action can only be performed after cleaning is completed.

[0047] The sample analyzer of the embodiment of the present application includes a dispensing mechanism, a liquid path supporting mechanism, and an ultrasonic cleaning device 200 .

[0048] The dispensing mechanism comprises a moving part and a pipette needle 4 arranged on the moving part; the moving part is used to drive the pipette needle 4 to move between different operating positions to absorb or discharge the target liquid, and the target liquid comprises at least one of a sample or a reagent.

[0049] The dispensing mechanism may be the sample dispensing mechanism described above, or may be the reagent dispensing mechanism described above.

[0050] The pipetting needle 4 may be the sample needle mentioned above, or may be the reagent needle mentioned above.

[0051] The ultrasonic cleaning device 200 includes an ultrasonic generator 21 and a cleaning tank 22 .

[0052] See also Figure 6 The ultrasonic generator 21 includes an ultrasonic transducer 211 and a vibration part 212 connected to each other. The vibration part 212 can also be understood as a horn, which can amplify the particle displacement or velocity of the mechanical vibration of the ultrasonic transducer 211 and concentrate the ultrasonic energy on the end surface 212a of the vibration part 212 away from the vibration end of the ultrasonic transducer 211.

[0053] See also Figures 2 to 4 The cleaning pool 22 includes a liquid storage chamber 221 for containing cleaning liquid, and the top side of the liquid storage chamber 221 has an opening. The liquid path support mechanism is used to provide cleaning liquid to the liquid storage chamber 221.

[0054] The moving part is also used to drive the pipette needle 4 to move from the opening into the cleaning liquid in the liquid storage chamber 221, and the vibration part 212 is used to transmit the ultrasonic vibration of the ultrasonic transducer 211 to the cleaning liquid, so as to ultrasonically clean the pipette needle 4 through the cleaning liquid.

[0055] In the related art, the vibrating part is inserted into the cleaning liquid from the opening, and the vibrating part easily atomizes the cleaning liquid at the liquid surface, thereby generating an obvious fogging phenomenon.

[0056] In the embodiment of the present application, the side wall of the liquid storage cavity 221 is provided with an installation opening, and the vibration part 212 is sealed through the installation opening and inserted into the liquid storage cavity 221. In other words, the vibration part 212 will not be inserted into the liquid storage cavity 221 from the opening, so that the vibration part 212 can be completely or mostly immersed in the cleaning liquid, thereby improving the fogging phenomenon at the liquid surface of the cleaning liquid in the related art.

[0057] In the embodiment of the present application, the vibration part 212 directly transmits the ultrasonic vibration to the cleaning liquid, and there is no need to ultrasonically vibrate the wall of the cleaning tank 22. Therefore, it is possible to improve the stress conditions of the wall of the cleaning tank 22 and reduce the requirements for the fatigue strength and structural strength of the wall. In addition, the input-output conversion efficiency of the ultrasonic wave is higher.

[0058] Exemplarily, the material of the cleaning tank 22 includes plastic, which is not easy to generate noise during ultrasonic vibration, and can effectively reduce the noise of the cleaning tank during cleaning.

[0059] When it is necessary to remove the cleaning liquid in the cleaning tank 22, in some embodiments, the cleaning liquid can be pumped away through the opening by a pump and a suction pipeline.

[0060] In other embodiments, the liquid storage chamber 221 is provided with a drain port 221a, and when the cleaning liquid in the liquid storage chamber 221 needs to be discharged, the cleaning liquid in the liquid storage chamber 221 can be discharged from the drain port 221a. Exemplarily, the drain port 221a is provided at the lowest position of the bottom wall of the liquid storage chamber 221, so as to facilitate the emptying of the cleaning liquid in the liquid storage chamber 221.

[0061] Exemplarily, the end surface 212a of the vibration end and the side wall of the liquid storage chamber 221 are spaced to form a gap, and the moving component is used to drive the pipette needle 4 to pass through the gap in the height direction for ultrasonic cleaning. In other words, the gap is located on the moving path of the pipette needle 4.

[0062] Ultrasonic waves are longitudinal waves, and the end surface 212a of the vibration end of the vibration part 212 is the ultrasonic wave emitting surface. The energy density of the ultrasonic energy field at the end surface 212a of the vibration end is higher, and the sound field is more concentrated. Therefore, when the pipette needle 4 is in the gap, it has a better cleaning effect.

[0063] The method in which the liquid path support mechanism provides the cleaning liquid to the liquid storage chamber 221 is not limited.

[0064] For example, in some embodiments, the liquid circuit support mechanism includes a water tank, which is connected to the pipette needle 4 through a water supply pipeline, and the water supply pipeline is connected to a water pump and a syringe, an electromagnetic valve is connected between the syringe and the water pump, and the syringe is connected to a drive motor, which drives the piston movement of the syringe so that the pipette needle 4 absorbs and discharges liquid under the action of the power provided by the syringe.

[0065] Specifically, when the target liquid needs to be sucked, the solenoid valve is closed, and the piston of the syringe moves to realize the action of sucking and discharging the target liquid of the pipette needle 4. When the pipette needle 4 needs to be cleaned, the solenoid valve is opened, and the water pump pumps water into the water supply pipeline, so that water is continuously discharged from the pipette needle 4, and the cleaning liquid is discharged into the liquid storage chamber 221 through the pipette needle 4. This process can also perform preliminary cleaning on the inner wall of the pipette needle 4.

[0066] In this embodiment, the pipette needle 4 is reused, that is, the pipette needle 4 is used for both aspirating and discharging the target liquid and injecting the cleaning liquid into the liquid storage chamber 221 , so that the structure of the sample analyzer can be simplified and the cost can be reduced.

[0067] In some other embodiments, the liquid path support mechanism may not inject liquid into the liquid storage chamber 221 through the pipetting needle 4, for example, the liquid may be injected into the liquid storage chamber 221 through components such as pipelines and nozzles.

[0068] For example, see Figure 5 , the minimum width w of the gap is not less than 4 mm (millimeter), that is, w≥4 mm. In this way, the pipetting needle 4 can be smoothly inserted into the gap, it is not easy to hit the needle, and the positioning accuracy requirement of the pipetting needle 4 is reduced.

[0069] In some embodiments, the width of the gap is 4 mm to 10 mm, which can facilitate the smooth insertion of the pipette needle 4 into the gap without being too large, thus making the cleaning pool 22 compact and reducing the amount of cleaning solution.

[0070] For example, see Figure 5 , the distance h between the upper edge of the end surface 212a of the vibration end and the bottom wall of the pool below the end surface 212a of the vibration end is not less than 20mm, that is, h≥20mm. In this way, the pipette needle 4 has at least 20mm of length that has been ultrasonically cleaned at the gap. For details, please refer to Figure 2 The tip of the pipette needle 4 first extends into the gap, and as the pipette needle 4 gradually moves downward, the total length of the pipette needle 4 passing through the gap is not less than 20 mm. In this way, at least the cleaning requirements of the tip of the pipette needle 4 and the area near the tip can be met.

[0071] It is understandable that the tip of the pipette needle 4 and the area near the tip have the greatest need for cleaning, and the end of the pipette needle 4 close to the moving part generally does not need to contact the sample, reagent, etc., so the cleaning demand is not great or does not need to be cleaned.

[0072] Exemplarily, the distance h between the upper edge of the end surface 212a of the vibration end and the bottom wall of the pool below the end surface 212a of the vibration end is not less than 60 mm. That is, 60 mm ≤ h ≤ 100 mm, for example, 60 mm, 70 mm, 80 mm, 90 mm, 100 mm, etc. If the distance is too large, far exceeding the length of various types of pipette needles 4, on the one hand, the size is too large, which is not conducive to compactness, and on the other hand, it is more wasteful of cleaning fluid.

[0073] In some embodiments, the distance between the upper edge of the end surface 212a of the vibrating end and the bottom wall of the pool below the end surface 212a of the vibrating end is not greater than 100 mm, that is, 60 mm ≤ h ≤ 100 mm, for example, 60 mm, 70 mm, 80 mm, 90 mm, 100 mm, etc.

[0074] For example, see Figure 2 The bottom wall of the liquid storage chamber 221 includes a first bottom wall 2215 and a second bottom wall 2214, wherein the first bottom wall 2215 is higher than the second bottom wall 2214, and the second bottom wall 2214 is located below the gap. For example, the bottom wall of the pool is a stepped structure. The depth of the portion of the liquid storage chamber 221 above the first bottom wall 2215 is less than the depth of the portion above the second bottom wall 2214. During ultrasonic cleaning, the pipetting needle 4 is cleaned in the area above the second bottom wall 2214, so the depth of the area above the second bottom wall 2214 can meet the cleaning depth requirement of the pipetting needle 4, and the raised design of the first bottom wall 2215 can reduce the volume of the liquid storage chamber 221 and reduce the amount of cleaning solution while meeting the cleaning requirements of the pipetting needle 4.

[0075] In some other embodiments, please refer to Figure 4 The local liquid of the bottom wall of the liquid storage chamber 221 does not need to be raised, and the bottom wall can be kept flat.

[0076] The vibration part 212 may be arranged horizontally or inclined relative to the horizontal plane.

[0077] For some examples, see Figure 2 , Figure 4 and Figure 5 , the vibration part 212 can be arranged horizontally. In other embodiments, please refer to Figure 3 , the vibrating end can be arranged obliquely upward. In some embodiments not shown, the vibrating end can also be arranged obliquely downward.

[0078] Exemplarily, any part of the vibration part 212 does not exceed the liquid level when the liquid storage chamber 221 overflows. The liquid level when overflowing is the designed maximum liquid level of the liquid storage chamber 221, that is, the theoretical maximum value of the liquid level of the liquid storage chamber 221 is the liquid level when overflowing. It should be noted that in actual use, the liquid level in the liquid storage chamber 221 can be at the liquid level when overflowing, or it can be lower than the liquid level when overflowing.

[0079] In this embodiment, the vibration part 212 can be substantially or mostly submerged in the cleaning liquid, which can further improve or avoid the fogging phenomenon on the liquid surface.

[0080] For example, see Figures 2 to 5The cleaning pool 22 includes a first overflow chamber 222 , and the first overflow chamber 222 is used to receive the cleaning liquid overflowing from the liquid storage chamber 221 .

[0081] When the liquid path support mechanism continues to inject liquid into the liquid storage chamber 221 and the overflow liquid level of the liquid storage chamber 221 is reached, the excess cleaning liquid overflows into the overflow chamber and does not spread to the outside of the cleaning pool 22 .

[0082] For example, see Figure 2 The first overflow chamber 222 is provided with an outlet 222 a, and the outlet 222 a is used to discharge the cleaning liquid in the first overflow chamber 222 .

[0083] It should be noted that, in some embodiments, the outlet 222a may be in a normally open state, that is, as long as the cleaning liquid enters the first overflow chamber 222, it can be discharged from the outlet 222a at any time. In other embodiments, a control valve is provided at the outlet 22a, or a control valve is provided on the pipeline connected to the outlet 222a. When the liquid level in the first overflow chamber 222 reaches a certain height, the control valve can be opened to discharge the cleaning liquid in the first overflow chamber 222 in a centralized manner.

[0084] For example, see Figures 2 to 5 The cleaning pool 22 includes a second overflow chamber 223, and the second overflow chamber 223 is used to receive the cleaning liquid leaking from the installation port. It should be noted that after the vibration part 212 passes through the installation port, the vibration part 212 and the installation port need to be sealed. In normal product design, the cleaning liquid will not leak from the connection between the installation port and the vibration part 212. However, the installation port may leak. Therefore, in the embodiment of the present application, the second overflow chamber 223 can receive the cleaning liquid leaking from the installation port to prevent the leaked liquid from spreading to other parts outside the cleaning pool.

[0085] For example, see Figure 2 The second overflow chamber 223 is provided with an outlet 223 a, and the outlet 223 a is used to discharge the cleaning liquid in the second overflow chamber 223 .

[0086] In some embodiments, the first overflow chamber 222 and the second overflow chamber 223 can be isolated from each other, that is, the first overflow chamber 222 and the second overflow chamber 223 are not interconnected, the cleaning liquid in the first overflow chamber 222 will not flow to the second overflow chamber 223, and the cleaning liquid in the second overflow chamber 223 will not flow to the first overflow chamber 222.

[0087] In some other embodiments, the first overflow chamber 222 and the second overflow chamber 223 are connected to each other, so that the cleaning liquid can be discharged from both through the same outlet.

[0088] For example, see Figure 5The side walls of the liquid storage chamber 221 include a first side wall 2211, a second side wall 2212, and two third side walls 2213. The first side wall 2211 and the second side wall 2212 are located on opposite sides of the liquid storage chamber 221, that is, the first side wall 2211 and the second side wall 2212 are opposite, and the two third side walls 2213 are opposite. The two third side walls 2213 are respectively connected to the first side wall 2211 and the second side wall 2212. In other words, the liquid storage chamber 221 is roughly a cuboid or a cube.

[0089] The installation opening passes through the first side wall 2211, and the vibration part 212 passes through the first side wall 2211 and extends toward the second side wall 2212. The end surface 212a of the vibration end and the second side wall 2212 are spaced apart to form the above-mentioned gap.

[0090] A notch 221c is provided at the top of at least one third side wall 2213 and / or the top of the second side wall 2212, and the cleaning liquid in the liquid storage chamber 221 overflows to the first overflow chamber 222 through the notch 221c. In other words, the height of the notch 221c determines the overflow liquid level.

[0091] In this embodiment, since the notch 221c is arranged on the third side wall 2213 and / or the second side wall 2212, when the cleaning liquid overflows from the notch 221c, the cleaning liquid will not flow downward from the outer surface of the first side wall 2211, and therefore will not flow onto the ultrasonic transducer 211, thereby preventing the cleaning liquid from causing problems such as short circuit of the ultrasonic transducer 211 and corrosion of electronic components.

[0092] In other embodiments, the height of the second side wall 2212 and / or the third side wall 2213 is lower than the height of the first side wall 2211, so that the cleaning liquid in the liquid storage chamber 221 overflows to the first overflow chamber 222 through the top edge of the third side wall 2213 and / or the top edge of the second side wall 2212. In this embodiment, the top edge of the second side wall 2212 and / or the top edge of the third side wall 2213 can be kept neat. In addition, when the cleaning liquid overflows, the cleaning liquid will not flow downward from the outer surface of the first side wall 2211, and therefore will not flow onto the ultrasonic transducer 211, thereby preventing the cleaning liquid from causing problems such as short circuit of the ultrasonic transducer 211 and corrosion of electronic components.

[0093] In some embodiments, the dimension of the end surface 212a of the vibration end in the vertical direction is greater than the dimension in the horizontal direction. Thus, under the same power of the ultrasonic transducer 211, the energy density of the end surface 212a of the vibration end of the vibration part 212 is greater, and the sound field has a relatively long length in the vertical direction of the end surface 212a of the vibration end, so when the pipette needle 4 moves up and down in the gap, it has a better cleaning effect.

[0094] The shape of the end surface 212a of the vibration end is not limited.

[0095] For example, the shape of the end face 212a of the vibration end includes one of a rectangle, an ellipse, and an oval. For example, in an embodiment where the shape of the end face 212a of the vibration end of the vibration part 212 is a rectangle, the long side of the rectangle is roughly along the vertical direction, and the short side of the rectangle is roughly along the horizontal direction. For another example, in an embodiment where the shape of the end face 212a of the vibration end is an ellipse, the major axis of the ellipse is roughly along the vertical direction, and the minor axis of the ellipse is roughly along the horizontal direction. For another example, in an embodiment where the shape of the end face 212a of the vibration end is an oval, the major axis of the ellipse is roughly along the vertical direction, and the minor axis of the ellipse is roughly along the horizontal direction.

[0096] It should be noted that a waist circle refers to a closed figure formed by dividing a circle into two semicircular arcs through the center of the circle and translating them in opposite directions, and connecting the end points of the two semicircular arcs with two parallel lines of equal length.

[0097] For example, in some embodiments, please refer to Figure 6 The circumferential outer surface of the vibration part 212 includes a pair of cut surfaces 212b and a pair of arc surfaces 212c, and the cut surfaces 212b and the arc surfaces 212c both extend axially to the end surface 212a of the vibration end. The pair of cut surfaces 212b are provided on the surfaces of the vibration part 212 on opposite sides along the first direction and are arranged symmetrically, and the pair of arc surfaces 212c are provided on the surfaces of the vibration part 212 on opposite sides along the second direction and are arranged symmetrically.

[0098] The cut surface 212b can be understood as: a cut surface 212b formed after a part of the surface of a cylinder is cut off.

[0099] In this embodiment, the pair of arcs can be concentric circles, and the distance between the pair of cut surfaces 212b is less than the diameter of the concentric circles. The cross-sectional shape of the vibrating portion 212 is oval or similar to an oval. Under the same power of the ultrasonic generator, the end surface 212a has a larger power density, and the length between the pair of arcs is longer, thereby improving the cleaning effect of the pipette needle 4.

[0100] Exemplarily, the diameter of the circumscribed circle of the circumferential surface of the vibration part 212 does not exceed 50 mm. The circumscribed circle of the circumferential surface of the vibration part 212 can be understood as: the circumscribed circle corresponding to the cross-sectional shape of the vibration part 212 in the cross section perpendicular to the extension direction thereof.

[0101] It should be noted that, from the end close to the ultrasonic transducer 211 to the end surface 212a of the vibration end, the vibration part 212 may be set in equal diameter or non-equal diameter. For example, in some embodiments, from the end close to the ultrasonic transducer 211 to the end surface 212a of the vibration end, the diameters of the circumscribed circles of the circumferential surface of the vibration part 212 are the same, that is, equal diameter. In other embodiments, from the end close to the ultrasonic transducer 211 to the end surface 212a of the vibration end, the diameter of the circumscribed circle of the circumferential surface of the vibration part 212 continuously decreases, or decreases in a jumpy manner, etc., that is, non-equal diameter.

[0102] For example, the entire vibration part 212 is symmetrical about the central axis of the vibration part 212. The central axis of the vibration part 212 refers to: a line connecting the centers of the cross sections at any part of the vibration part 212. In this way, the shear force on any two opposite sides of the vibration part 212 during the vibration process can be relatively uniform, thereby improving the stress conditions of the vibration part 212 and increasing its service life.

[0103] Exemplarily, the sample analyzer includes a detection device and a controller. The detection device is used to: detect the liquid level of the liquid storage chamber 221 when cleaning liquid has been stored in the liquid storage chamber 221 and the liquid path support mechanism stops providing cleaning liquid to the liquid storage chamber 221; the controller is used to determine whether the liquid storage chamber 221 is leaking based on the liquid level information.

[0104] In this embodiment, during the process of the detection device detecting the liquid level, the liquid path support mechanism will not inject liquid into the liquid storage chamber 221, so that the detection device can more accurately obtain the current liquid level of the liquid storage chamber 221, which is convenient for the controller to determine whether the liquid storage chamber 221 is leaking. For example, when the controller determines that there is a liquid leak in the liquid storage chamber 221, a warning message can be issued to remind the user to check the sample analyzer, so that the reliability of the sample analyzer can be improved.

[0105] In some specific embodiments, for example, a certain volume of cleaning liquid is first quantitatively injected into the liquid storage chamber 221 through the liquid circuit support mechanism, for example, 30 ml (milliliters) or 40 ml of cleaning liquid is injected each time, and the flow rate of the cleaning liquid is actively controlled by the liquid circuit support mechanism. After the injection, the liquid level of the cleaning liquid is determined, and the determined liquid level information can be pre-stored in the controller, that is, the default injection level. After that, the detection device detects the liquid level of the liquid storage chamber 221, and determines whether there is a leakage based on the difference between the default injection level and the liquid level detected by the detection device. For example, when there is no difference, or the difference is less than the set value, it is determined that there is no leakage; when the difference value reaches or exceeds the set value, it is determined that there is a leakage.

[0106] In other embodiments, the liquid level of the liquid storage chamber 221 may be detected twice by a detection device, and the controller determines whether there is leakage based on the difference between the two detected liquid levels.

[0107] The specific structure of the detection device is not limited.

[0108] For example, in some embodiments, the detection device includes a detection circuit, and the pipette needle 4 is connected to the detection circuit as a variable impedance. The moving part is also used to drive the pipette needle 4 to be inserted into the cleaning liquid at least twice in succession. The detection circuit is used to detect the impedance change of the pipette needle 4 and output an electrical signal representing the liquid level. The controller is used to determine whether the liquid storage chamber 221 is leaking based on the electrical signal.

[0109] In this embodiment, the pipette needle 4 is connected to the detection circuit as a generalized impedance. For example, taking the pipette needle 4 as a capacitor in the detection circuit, the detection circuit can calculate the current capacitance of the pipette needle 4 through the working voltage. When the pipette needle 4 contacts the liquid surface, its capacitance will change greatly. At this time, the working voltage will also change. In this way, the controller can determine whether the pipette needle 4 contacts the liquid surface based on the change in the working voltage. At this time, the height of the tip of the sample needle is the same as the height of the liquid level in the liquid storage chamber 221. In this way, the liquid level in the liquid storage chamber 221 can be determined.

[0110] In other embodiments, the detection device may include a sensor, which is disposed on the cleaning tank 22 to detect the liquid level in the liquid storage chamber 221 .

[0111] Exemplarily, the sample analyzer includes a flexible sealing structure and a connecting structure. The flexible sealing structure is used to seal the gap between the mounting port and the ultrasonic transducer 211 to reduce the probability of leakage of the cleaning liquid from the mounting port.

[0112] The ultrasonic transducer 211 is spaced apart from the side wall of the liquid storage chamber 221 , that is, any part of the ultrasonic transducer 211 is not in direct contact with the side wall of the liquid storage chamber 221 , and the vibration of the ultrasonic transducer 211 is not directly transmitted to the side wall of the liquid storage chamber 221 .

[0113] The connection structure is connected to the side wall of the liquid storage chamber 221, for example, by screws 24, and the ultrasonic transducer 211 is fixed to the side wall of the liquid storage chamber 221 by the flexible sealing structure. The connection structure plays a role of connecting and applying force to the flexible sealing structure. The connection structure is not in direct contact with the ultrasonic transducer 211. The connection structure applies force to the flexible sealing structure, and the flexible sealing structure transmits the force to the ultrasonic transducer 211, thereby fixing the ultrasonic transducer 211 to the side wall of the liquid storage chamber 221.

[0114] The material of the flexible sealing structure is not limited. For example, materials with resilience such as rubber and silicone can be used.

[0115] The shape of the connection structure is not limited, and the shape of the flexible sealing structure is not limited.

[0116] Exemplarily, the hole wall of the installation port is formed with an annular step surface, and the step surface faces the outside of the liquid storage cavity 221. Figure 6 A convex ring 2111 is formed on the circumferential surface of the ultrasonic transducer 211 , that is, the convex ring 2111 protrudes from the circumferential surface of the ultrasonic transducer 211 .

[0117] See also Figure 5 The flexible sealing structure includes a first sealing ring 231 and a second sealing ring 232. The first sealing ring 231 and the second sealing ring 232 are sleeved on the ultrasonic transducer 211 and are located on two opposite axial sides of the convex ring 2111. During assembly, the first sealing ring 231 is sleeved on the ultrasonic transducer 211 from one end of the vibration part 212, and the second sealing ring 232 is sleeved on the ultrasonic transducer 211 from one end of the ultrasonic transducer 211 away from the vibration part 212.

[0118] The connection structure includes a flange 233 , which is sleeved on the circumference of the ultrasonic transducer 211 and spaced apart from the ultrasonic transducer 211 , that is, the two are not in direct contact.

[0119] The first sealing ring 231 is sandwiched between the step surface and the surface of the first side of the convex ring 2111, and the second sealing ring 232 is sandwiched between the surface of the second side of the convex ring 2111 and the flange 233. The flange 233 is connected to the side wall of the liquid storage chamber 221, and applies a squeezing force toward the liquid storage chamber 221 to the second sealing ring 232, the convex ring 2111 and the first sealing ring 231. In this way, the convex ring 2111 is clamped by the first sealing ring 231 and the second sealing ring 232, so as to realize the installation and fixation of the ultrasonic transducer 211, and the ultrasonic transducer 211 is neither in contact with the side wall of the liquid storage chamber 221 nor in contact with the flange 233.

[0120] Exemplarily, during the ultrasonic cleaning process, the moving component is used to drive the pipette needle 4 to intermittently move up and down and / or reciprocate up and down at least twice in the gap of the cleaning liquid to achieve ultrasonic cleaning of the pipette needle 4. In this way, the cleaning effect can be improved.

[0121] Among them, the pipette needle 4 moves up and down intermittently in the gap of the cleaning liquid, which means that after the pipette needle 4 is inserted into the cleaning liquid, it stays for a short time, moves downward a short distance, stays for a short time again, and continues to move downward for a distance. When it is inserted to a predetermined depth, it moves upward a short distance, stays for a short time, and then continues to move upward. In other words, each time it moves a short distance, stays for a short time, and then continues to move, until the cleaning is completed, the pipette needle 4 is moved upward out of the liquid storage cavity 221.

[0122] It can be understood that the intermittent up and down movement can be performed only once or multiple times.

[0123] The up-and-down reciprocating motion at least twice means that the downward movement and the upward movement are alternately performed for at least two rounds. There are two situations. The first one is that the pipette needle 4 moves continuously without stopping in the middle, and the continuous upward movement and the continuous downward movement are alternately performed. The second one is that the pipette needle 4 can also move intermittently, stopping during the downward movement and stopping during the upward movement, and the upward movement and the downward movement are alternately performed.

[0124] The embodiment of the present application provides a sample analyzer, including a dispensing mechanism, an ultrasonic cleaning device 200 and a liquid path support mechanism.

[0125] The dispensing mechanism comprises a moving part and a pipette needle 4 arranged on the moving part; the moving part is used to drive the pipette needle 4 to move between different operating positions to absorb or discharge the target liquid, and the target liquid comprises at least one of a sample or a reagent.

[0126] The dispensing mechanism may be the dispensing mechanism in any of the above-mentioned embodiments, which will not be described in detail here.

[0127] The ultrasonic cleaning device 200 includes an ultrasonic generator 21 and a cleaning tank 22, wherein the ultrasonic generator 21 includes an ultrasonic transducer 211 and a vibration part 212 connected to each other;

[0128] The cleaning tank 22 includes a liquid storage cavity 221 for containing cleaning liquid, and the top side of the liquid storage cavity has an opening. The material of the cleaning tank 22 includes plastic. The vibrating part 212 extends into the liquid storage cavity 221, and any part thereof does not exceed the liquid level when the liquid storage cavity 221 overflows.

[0129] The liquid path supporting mechanism is used to provide cleaning liquid to the liquid storage chamber 221 .

[0130] The liquid path support mechanism can be the dispensing mechanism in any of the above embodiments, which will not be described in detail here.

[0131] The moving part is also used to drive the pipette needle 4 to move from the opening into the cleaning liquid in the liquid storage chamber 221, and the vibration part 212 is used to transmit the ultrasonic vibration of the ultrasonic transducer 211 to the cleaning liquid, so as to ultrasonically clean the pipette needle 4 through the cleaning liquid.

[0132] In the sample analyzer of this embodiment, the liquid level at overflow is the designed maximum liquid level of the liquid storage chamber 221, that is, the theoretical maximum value of the liquid level of the liquid storage chamber 221 is the liquid level at overflow. It should be noted that in actual use, the liquid level in the liquid storage chamber 221 can be at the liquid level at overflow, or it can be lower than the liquid level at overflow. In this embodiment, the vibration part 212 can be basically completely submerged in the cleaning liquid, which can further improve or avoid the phenomenon of fogging on the liquid surface.

[0133] Exemplarily, the end surface 212a of the vibration end and the side wall of the liquid storage chamber 221 are spaced apart to form a gap, and the moving component is used to drive the pipette needle 4 to pass through the gap along the height direction to perform ultrasonic cleaning.

[0134] Exemplarily, the distance between the upper edge of the end surface 212a of the vibration end and the bottom wall of the pool below the end surface 212a of the vibration end is 20 mm to 100 mm, for example, 20 mm, 26 mm, 30 mm, 34 mm, 40 mm, 45 mm, 50 mm, 60 mm, 70 mm, 80 mm, 90 mm, 100 mm, etc. When the pipette needle absorbs the whole blood sample, it needs to be lowered to the deeper part of the sample tube to absorb the sample, and the contamination height of the outer surface of the needle is relatively high. The distance between the upper edge of the end surface 212a of the vibration end and the bottom wall of the pool below the end surface 212a of the vibration end is not less than 20 mm to clean the contamination caused by the pipette needle absorbing the whole blood sample, preferably, not less than 40 mm, and more preferably, not less than 60 mm. In this field, the length of the pipette needle is usually not too long. The upper edge of the end face 212a of the vibrating end and the bottom wall of the pool below the end face 212a of the vibrating end are 100 mm, which can better clean the outer surface of the needle without wasting the cleaning liquid due to the cleaning pool being too deep.

[0135] For example, in some embodiments, the distance between the upper edge of the end surface 212a of the vibration end and the pool bottom wall below the end surface 212a of the vibration end is preferably 60 mm to 100 mm.

[0136] Exemplarily, the dimension of the end face 212a of the vibration end in the vertical direction is larger than that in the horizontal direction. Thus, under the same power of the ultrasonic transducer 211, the energy density of the end face 212a of the vibration end of the vibration part 212 is greater, and the sound field has a relatively long length in the vertical direction of the end face 212a of the vibration end, so when the pipette needle 4 moves up and down in the gap, it has a better cleaning effect.

[0137] The sample analyzer, the structure of the ultrasonic transducer, the structure of the liquid storage chamber, etc. of the embodiment of the present application can refer to the structure in any of the above embodiments and will not be described in detail here.

[0138] In the description of the present application, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiments of the present application. In the present application, the schematic representation of the above terms is not necessarily for the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine different embodiments or examples described in the present application and the features of different embodiments or examples without contradiction.

[0139] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A sample analyzer, characterized in that: include: The dispensing mechanism comprises a moving part and a pipetting needle arranged on the moving part; The moving component is used to drive the pipetting needle to move between different operating positions to absorb or discharge a target liquid, wherein the target liquid includes at least one of a sample or a reagent; An ultrasonic cleaning device comprises an ultrasonic generator and a cleaning tank, wherein the ultrasonic generator comprises an ultrasonic transducer and a vibrating part connected to each other; the cleaning tank is made of plastic, and comprises a liquid storage cavity for accommodating a cleaning liquid, wherein the top side of the liquid storage cavity has an opening, and the side wall of the liquid storage cavity is provided with a mounting opening, and the vibrating end of the vibrating part away from the ultrasonic transducer is sealedly passed through the mounting opening and inserted into the liquid storage cavity, A liquid circuit support mechanism, the liquid circuit support mechanism is used to provide cleaning liquid to the liquid storage chamber; The moving component is also used to drive the pipette needle to move from the opening into the cleaning liquid in the liquid storage chamber, and the vibrating part is used to transmit the ultrasonic vibration of the ultrasonic transducer to the cleaning liquid to ultrasonically clean the pipette needle through the cleaning liquid.

2. The sample analyzer according to claim 1, characterized in that: The end surface of the vibration end and the side wall of the liquid storage chamber are spaced apart to form a gap, and the moving component is used to drive the pipetting needle to pass through the gap along the height direction to perform ultrasonic cleaning.

3. The sample analyzer according to claim 2, characterized in that: The minimum width of the gap is not less than 4 mm.

4. The sample analyzer according to claim 1, characterized in that: The distance between the upper edge of the end surface of the vibration end and the pool bottom wall below the end surface of the vibration end is not less than 20 mm.

5. The sample analyzer according to claim 4, characterized in that: The distance between the upper edge of the end surface of the vibration end and the pool bottom wall below the end surface of the vibration end is no more than 100 mm.

6. The sample analyzer according to claim 5, characterized in that: The distance between the upper edge of the end surface of the vibration end and the pool bottom wall below the end surface of the vibration end is not less than 60 mm.

7. The sample analyzer according to claim 2, characterized in that: The bottom wall of the liquid storage cavity includes a first bottom wall and a second bottom wall, the first bottom wall is higher than the second bottom wall, and the second bottom wall is located below the gap.

8. The sample analyzer according to claim 1, characterized in that: Any part of the vibrating portion does not exceed the liquid level when overflow occurs in the liquid storage chamber.

9. The sample analyzer according to claim 1, characterized in that: The cleaning pool includes a first overflow cavity, the first overflow cavity is used to receive the cleaning liquid overflowing from the liquid storage cavity, and the first overflow cavity is provided with an outlet, and the outlet is used to discharge the cleaning liquid overflowing into the first overflow cavity.

10. The sample analyzer according to claim 9, characterized in that: The side wall of the liquid storage cavity comprises a first side wall, a second side wall and two third side walls, the first side wall and the second side wall are located at opposite sides of the liquid storage cavity, the installation opening passes through the first side wall, the vibration part passes through the first side wall and extends toward the second side wall, and the two third side walls are respectively connected to the first side wall and the second side wall; A notch is provided at the top of at least one of the third side walls and / or the top of the second side wall, and the cleaning liquid in the liquid storage chamber overflows into the first overflow chamber through the notch; or, the height of the third side wall and / or the second side wall is lower than that of the first side wall, so that the cleaning liquid in the liquid storage chamber overflows into the first overflow chamber through the top edge of the third side wall and / or the top edge of the second side wall.

11. The sample analyzer according to claim 1, characterized in that: The cleaning pool includes a second overflow cavity, and the second overflow cavity is used to receive the cleaning liquid leaking from the installation port.

12. The sample analyzer according to claim 1, characterized in that: The dimension of the end surface of the vibration end in the vertical direction is greater than that in the horizontal direction.

13. The sample analyzer according to claim 1, characterized in that: The shape of the end surface of the vibration end includes one of a rectangular shape, an elliptical shape, and an oval shape.

14. The sample analyzer according to claim 1, characterized in that: The circumferential outer surface of the vibration part includes a pair of cut surfaces and a pair of arc surfaces, and the cut surfaces and the arc surfaces both extend axially to the end surface of the vibration end. The pair of cut surfaces are set on the surfaces of the vibration part on opposite sides along the first direction and are arranged symmetrically, and the pair of arc surfaces are set on the surfaces of the vibration part on opposite sides along the second direction and are arranged symmetrically.

15. The sample analyzer according to claim 1, characterized in that: The diameter of the circumscribed circle of the circumferential surface of the vibrating portion does not exceed 50 mm.

16. The sample analyzer according to claim 1, characterized in that: The entirety of the vibration portion is symmetrical about a central axis of the vibration portion.

17. The sample analyzer according to claim 1, characterized in that: The sample analyzer includes a detection device and a controller. The detection device is used to detect the liquid level of the liquid storage chamber when cleaning liquid has been stored in the liquid storage chamber and the liquid path support mechanism stops providing cleaning liquid to the liquid storage chamber. The controller is used to determine whether the liquid storage chamber is leaking based on the liquid level information.

18. The sample analyzer according to claim 17, characterized in that: The detection device includes a detection circuit, the pipette needle is connected to the detection circuit as a variable impedance, the moving component is also used to drive the pipette needle to be inserted into the cleaning liquid at least twice in succession, the detection circuit is used to detect the impedance change of the pipette needle and output an electrical signal representing the liquid level, and the controller is used to determine whether the liquid storage chamber is leaking based on the electrical signal.

19. The sample analyzer according to claim 1, characterized in that: The sample analyzer comprises a flexible sealing structure and a connecting structure, wherein the flexible sealing structure is used to seal the gap between the mounting port and the ultrasonic transducer, and the ultrasonic transducer is spaced apart from the side wall of the liquid storage chamber; The connecting structure is connected to the side wall of the liquid storage chamber, and the ultrasonic transducer is fixed on the side wall of the liquid storage chamber through the flexible sealing structure.

20. The sample analyzer according to claim 19, characterized in that: The hole wall of the mounting port is formed with an annular step surface, the circumferential surface of the ultrasonic transducer is formed with a convex ring, the flexible sealing structure includes a first sealing ring and a second sealing ring, the connecting structure includes a flange, the first sealing ring and the second sealing ring are sleeved on the ultrasonic transducer and are located on opposite axial sides of the convex ring, the first sealing ring is clamped between the step surface and the surface of the first side of the convex ring, the second sealing ring is clamped between the surface of the second side of the convex ring and the flange, the flange is connected to the side wall of the liquid storage chamber, and applies an extrusion force toward the liquid storage chamber to the second sealing ring, the convex ring and the first sealing ring.

21. The sample analyzer according to claim 2, characterized in that: During the ultrasonic cleaning process, the moving component is used to drive the pipette needle to intermittently move up and down and / or reciprocate up and down at least twice in the gap of the cleaning liquid to achieve ultrasonic cleaning of the pipette needle.

22. A sample analyzer, characterized in that: include: The dispensing mechanism comprises a moving part and a pipetting needle arranged on the moving part; The moving component is used to drive the pipetting needle to move between different operating positions to absorb or discharge a target liquid, wherein the target liquid includes at least one of a sample or a reagent; An ultrasonic cleaning device comprises an ultrasonic generator and a cleaning tank, wherein the ultrasonic generator comprises an ultrasonic transducer and a vibration part connected to each other; The cleaning tank comprises a liquid storage cavity for containing cleaning liquid, the top side of the liquid storage cavity has an opening, the material of the cleaning tank comprises plastic, the vibrating part extends into the liquid storage cavity, and any part thereof does not exceed the liquid level of the liquid storage cavity when overflow occurs; A liquid circuit support mechanism, the liquid circuit support mechanism is used to provide cleaning liquid to the liquid storage chamber; The moving component is also used to drive the pipette needle to move from the opening into the cleaning liquid in the liquid storage chamber, and the vibrating part is used to transmit the ultrasonic vibration of the ultrasonic transducer to the cleaning liquid to ultrasonically clean the pipette needle through the cleaning liquid.

23. The sample analyzer according to claim 22, characterized in that: The end surface of the vibration end of the vibration part and the side wall of the liquid storage chamber are spaced apart to form a gap, and the moving component is used to drive the pipette needle to pass through the gap along the height direction to perform ultrasonic cleaning.

24. The sample analyzer according to claim 22, characterized in that: The distance between the upper edge of the end surface of the vibration end of the vibration part and the pool bottom wall located below the end surface of the vibration end is 20 mm to 100 mm.

25. The sample analyzer according to claim 22, characterized in that: The dimension of the end surface of the vibration end of the vibration part in the vertical direction is greater than that in the horizontal direction.

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