Multi-channel multi-joint detection POCT full-automatic chemiluminescence equipment

Abstract

The multi-channel multi-joint-inspection POCT full-automatic chemiluminescence equipment comprises a mounting frame, a light-emitting device and a light-emitting device, the reaction bin assembly is loaded with a multi-joint detection reagent strip, the multi-joint detection reagent strip is used for detecting at least two markers, and the multi-joint detection reagent strip comprises a liquid sealing area, a public liquid area and a special liquid area of the liquid sealing area; the multi-channel multi-joint detection parallel pretreatment device comprises at least two rows of magnetic rods, each row of magnetic rods comprises at least two magnetic rods, and the at least two rows of magnetic rods are used for transferring magnetic particles in adjacent hole sites of a multi-joint detection reagent strip in a liquid sealing area; the film breaking assembly is used for breaking the sealing film of the public liquid area; the reaction bin assembly is used for moving the multi-joint detection reagent strip to the PMT assembly, and the PMT assembly is used for carrying out luminescence value detection on the detection position of the multi-joint detection reagent strip. According to the invention, multi-channel parallel processing and multi-joint detection are realized at the same time, the analysis efficiency of the equipment is ensured, and efficient detection of multiple detection items can be realized while the size of the equipment is controlled.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a multi-channel multi-detection POCT fully automatic chemiluminescence device. Background Art

[0002] As a rapidly developing non-radioactive immunoassay technology, chemiluminescent immunoassay technology has become one of the important directions of immunological detection. Its principle is to use chemiluminescent signals to directly measure immune reactions. Chemiluminescent equipment using chemiluminescent immunoassay technology has the advantages of high sensitivity, good repeatability, high accuracy, good specificity and wide linear range.

[0003] POCT (Point-Of-Care Testing) is a testing method that conducts clinical testing immediately at the sampling site, eliminating the complex processing procedures of specimens in laboratory tests, and quickly obtaining test results. It has the characteristics of instrument programming, simple operation, and fast reporting of results.

[0004] At present, by applying chemiluminescence immunoassay technology to POCT products, a multi-channel, multi-test POCT fully automatic chemiluminescence device has been manufactured. This device has the advantages of instant detection and rapid acquisition of diagnostic results, and has been rapidly and widely promoted in the in vitro diagnostic industry.

[0005] The multi-channel multi-test POCT fully automatic chemiluminescence equipment generally includes a reaction chamber module and a multi-channel parallel pre-processing module. The reaction chamber module is loaded with reagent strips sealed with various reagents, and the reagent strips are moved to the multi-channel parallel pre-processing module for corresponding processing, such as breaking the sealing film on the reagent hole, transferring magnetic particles, etc. The length of the reagent strip is affected by the number of test items. As the number of test items increases, the reagents sealed in the reagent strip also need to be increased accordingly, and the length of the reagent strip will also increase.

[0006] When the device is used for detection and analysis of multiple projects, the distance that the reaction chamber module needs to move with the reagent strip in the device will increase before the reagent strip can be moved to the multi-channel parallel pre-treatment module for corresponding processing. If a longer distance is required to enable the multi-channel parallel pre-treatment device to break the sealing film on the reagent strip, the size of the device will increase, which is not conducive to the miniaturization of the device and will also prolong the time for detection and obtaining diagnostic results.

[0007] In addition, the current multi-channel parallel pre-processing module can only transfer magnetic particles in one well on the reagent strip at a time. If magnetic particles in multiple wells need to be transferred, multiple operations are required, which increases the risk of cross-interference and prolongs the transfer time of the magnetic particles. In addition, since it takes a long time to transfer magnetic particles multiple times, the analysis efficiency of the equipment is affected. Summary of the invention

[0008] The embodiment of the present invention provides a multi-channel multi-detection POCT fully automatic chemiluminescence device, which aims to solve the technical problems of how to control the device volume and ensure the device detection speed when the reagent strip grows to meet multiple detection needs, and the existing multi-channel parallel pre-processing module requires multiple operations when transferring magnetic particles in multiple wells, resulting in an increased risk of cross-interference, prolonged transfer time of magnetic particles and affecting the analysis efficiency of the device.

[0009] The embodiment of the present invention is implemented as follows: a multi-channel multi-detection POCT fully automatic chemiluminescence device, comprising:

[0010] Install the frame;

[0011] A reaction chamber assembly provided on the mounting frame and used for loading a multiple test reagent strip, the reaction chamber assembly being reciprocatable along the length direction of the mounting frame, the multiple test reagent strip being used for detecting at least two markers, the multiple test reagent strip comprising a liquid sealing area, the liquid sealing area comprising a common liquid area and a dedicated liquid area distributed along the length direction of the multiple test reagent strip;

[0012] A multi-channel multi-joint test parallel pre-processing device is arranged on the mounting frame, the multi-channel multi-joint test parallel pre-processing device comprises at least two rows of magnetic bars arranged side by side along the moving direction of the reaction chamber assembly, each row of the magnetic bars has at least two magnetic bars, and the at least two rows of the magnetic bars are used to transfer the magnetic particles in the adjacent holes of the multi-joint test reagent strip into the liquid sealing area;

[0013] a membrane breaking component provided on the mounting frame and located at the rear end of the multi-channel multi-joint detection parallel pre-processing device, the membrane breaking component being used to break the sealing film of the common liquid area; and

[0014] The PMT component is arranged on the mounting frame and located at the rear end of the membrane breaking component. The reaction chamber component is used to move the multiple test reagent strip to the PMT component. The PMT component is used to detect the luminescence value of the detection position of the multiple test reagent strip.

[0015] Furthermore, the multi-channel multi-joint inspection parallel pre-processing device comprises:

[0016] A gantry is arranged on the bottom plate of the mounting frame, and a first driving element is arranged on the top of the gantry;

[0017] a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the first driving element and being able to rise and fall under the drive of the first driving element to suck and discharge the sample on the multiple test reagent strip; and

[0018] The sample pre-processing mechanism is arranged on the gantry, the sample pre-processing mechanism is connected to the first driving element in a transmission manner, and can be lifted and lowered under the drive of the first driving element, and at least two rows of magnetic bars are arranged on the sample pre-processing mechanism.

[0019] Furthermore, the sample pre-processing mechanism includes:

[0020] A first mounting frame provided on the gantry and drivingly connected to the first driving element, wherein the first driving element can drive the first mounting frame to rise and fall;

[0021] a second driving element disposed on the first mounting frame; and

[0022] A pre-processing component is arranged on the first mounting frame and is transmission-connected to the second driving element, at least two rows of magnetic bars are arranged on the pre-processing component and are transmission-connected to the second driving element, and the second driving element can drive at least two rows of magnetic bars to rise and fall to transfer magnetic particles.

[0023] Furthermore, the pre-processing component includes:

[0024] A magnetic bar device is arranged on the first mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are arranged at the bottom of the magnetic bar device, and the plurality of first loading heads are connected to the plurality of movable through holes in a one-to-one correspondence;

[0025] a first push plate disposed above the magnetic bar device, the first push plate being drivingly connected to the second driving element; and

[0026] There are multiple connecting rods arranged on the first pushing plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The second driving element can drive the first pushing plate to drive the magnetic bars to rise and fall in the corresponding active through holes so as to be separated from the first loading head or pass through the first loading head.

[0027] Furthermore, the magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly spaced and distributed along the width direction of the first push plate;

[0028] There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly spaced and distributed along the length direction of the first pushing plate.

[0029] Furthermore, the sample extraction mechanism includes:

[0030] A second mounting frame provided on the gantry and drivingly connected to the first driving element, wherein the first driving element can drive the second mounting frame to rise and fall;

[0031] a third driving element disposed on the second mounting frame; and

[0032] An extraction component is arranged on the second mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to rise and fall to suck and discharge samples.

[0033] Furthermore, the extraction component includes:

[0034] An injection device arranged on the second mounting frame, wherein a plurality of injection cavities are formed in the injection device, a plurality of second loading heads for loading tip heads are arranged at the bottom of the injection device, and the plurality of second loading heads are connected to the plurality of injection cavities in a one-to-one correspondence;

[0035] a second push plate disposed above the injection device, the second push plate being drivingly connected to the third driving element; and

[0036] A plurality of piston rods are arranged on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The third driving element can drive the second push plate to drive the piston rods to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0037] Furthermore, the sample extraction mechanism also includes:

[0038] A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the second push plate;

[0039] an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and

[0040] A separation plate is arranged at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

[0041] Furthermore, the plurality of syringe cavities are evenly spaced apart along the length direction of the injection device, the plurality of second loading heads are evenly spaced apart along the length direction of the injection device, and the plurality of piston rods are evenly spaced apart along the length direction of the second push plate.

[0042] Furthermore, the sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

[0043] Furthermore, the gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves;

[0044] A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

[0045] Furthermore, a first slide seat is provided on a side of the first mounting frame facing the gantry, a first slide rail is provided on a side of the gantry facing the first mounting frame, the first slide rail extends along a height direction of the gantry, and the first slide seat is slidably connected to the first slide rail;

[0046] A second slide seat is provided on a side of the second mounting frame facing the gantry, a second slide rail is provided on a side of the gantry facing the second mounting frame, the second slide rail extends along the height direction of the gantry, and the second slide seat is slidably connected to the second slide rail.

[0047] Furthermore, a first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame, and the first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises and falls;

[0048] A second sensing member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second sensing member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

[0049] Furthermore, the reaction chamber assembly comprises:

[0050] A guide rail provided on the bottom plate of the mounting frame;

[0051] A reaction chamber body is arranged on the guide rail, a guide block is arranged at the bottom of the reaction chamber body and is slidably connected to the guide rail, and a plurality of evenly spaced receiving grooves are arranged on the reaction chamber body for loading the multi-test reagent strips, and the receiving grooves extend along the length direction of the reaction chamber body;

[0052] A fourth driving element is arranged on the bottom plate of the mounting frame and located at the rear end of the guide rail, and a first driving pulley is arranged on the transmission shaft of the fourth driving element;

[0053] a mounting seat disposed on the bottom plate of the mounting frame and located at the front end of the guide rail, the mounting seat being provided with a first driven pulley, the first driving pulley being transmission-connected to the first driven pulley via a belt; and

[0054] A first synchronous belt pressure plate is arranged on one side of the reaction chamber body, and the first synchronous belt pressure plate is connected to a belt.

[0055] Furthermore, the PMT assembly comprises:

[0056] A mounting bracket disposed on the bottom plate of the mounting frame;

[0057] a third mounting bracket disposed on the mounting bracket;

[0058] a fourth mounting frame disposed at the bottom of the third mounting frame;

[0059] A PMT module disposed on the fourth mounting frame;

[0060] A fifth driving element disposed on the top of the third mounting frame and drivingly connected to the fourth mounting frame, the fifth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down;

[0061] A sixth driving element and a second driven pulley are respectively arranged on both sides of the top of the mounting bracket, a second driving pulley is arranged on the transmission shaft of the sixth driving element, and the second driving pulley is connected to the second driven pulley through a belt; and

[0062] A second synchronous belt pressure plate is arranged on the third mounting frame, and the second synchronous belt pressure plate is connected to the belt.

[0063] Furthermore, the membrane breaking component comprises:

[0064] a seventh driving element disposed on the top of the mounting bracket;

[0065] a fifth mounting frame disposed on the mounting bracket and located below the seventh driving element, wherein the fifth mounting frame is drivingly connected to the seventh driving element and can be raised and lowered under the drive of the seventh driving element; and

[0066] A plurality of membrane breaking heads are arranged at the bottom of the fifth mounting frame, and the plurality of membrane breaking heads are evenly distributed along the length direction of the fifth mounting frame.

[0067] Furthermore, the multiple test reagent strip comprises:

[0068] A reagent strip body, wherein the liquid sealing area is disposed on the reagent strip body;

[0069] a handle disposed at one end of the test strip body; and

[0070] A sample hole, a tip, at least two disposable magnetic separation sleeves, the dedicated liquid area and the common liquid area are arranged on the reagent strip body in sequence from the handle to the other end of the reagent strip body;

[0071] The dedicated liquid area includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area includes a cleaning liquid and a luminescent substrate liquid.

[0072] In an embodiment of the present invention, the multi-channel multi-joint detection parallel pre-processing device includes at least two rows of magnetic bars for transferring magnetic particles, and each row has at least two magnetic bars, that is, the multi-channel multi-joint detection parallel pre-processing device can simultaneously transfer the magnetic particles in at least two adjacent reagent wells on a single multi-joint detection reagent strip, and transfer the magnetic particles in adjacent reagent wells of at least two multi-joint detection reagent strips arranged in parallel, thereby realizing the analysis and detection of at least two markers, realizing multi-joint detection while realizing multi-channel parallel processing, reducing the risk of cross infection, shortening the time for transferring magnetic particles, and ensuring the analysis efficiency of the equipment.

[0073] Furthermore, based on the structure of the equipment and in combination with the special design of the multi-test reagent strip, the operation of breaking the sealing film of the multi-test reagent strip does not need to be completely performed by the multi-channel multi-test parallel pre-treatment device, but the sealing film of the common liquid area can be broken by the membrane breaking component at the rear end, and the reaction chamber component does not need to move the multi-test reagent strip for a long distance to achieve targeted membrane breaking, thereby reducing the repeated and long-distance movement of the reaction chamber component and the repeated membrane breaking work of the multi-channel multi-test parallel pre-treatment device, and can achieve efficient detection of multiple detection items while controlling the volume of the multi-channel multi-test POCT fully-automatic chemiluminescence equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0074] Figure 1 4 is a three-dimensional schematic diagram of a multi-channel multi-detection POCT fully automatic chemiluminescence device according to an embodiment of the present invention;

[0075] Figure 2 It is another three-dimensional schematic diagram of a multi-channel multi-joint detection POCT fully automatic chemiluminescence device which is part of an embodiment of the present invention;

[0076] Figure 3 It is another three-dimensional schematic diagram of a multi-channel multi-joint detection POCT fully automatic chemiluminescence device which is part of an embodiment of the present invention;

[0077] Figure 4 is a schematic structural diagram of a multiple test reagent strip according to an embodiment of the present invention;

[0078] Figure 5 is a cross-sectional schematic diagram of a multiple test reagent strip according to an embodiment of the present invention;

[0079] Figure 6 2 is a three-dimensional schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0080] Figure 7 is another three-dimensional schematic diagram of the multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0081] Figure 8 It is a three-dimensional disassembly schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0082] Fig. 9 2 is a schematic diagram of the structure of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0083] Fig.10 is a three-dimensional schematic diagram of a gantry according to an embodiment of the present invention;

[0084] Fig.11 is another three-dimensional schematic diagram of the gantry according to an embodiment of the present invention;

[0085] Fig.12 is a three-dimensional schematic diagram of a sample pre-processing mechanism according to an embodiment of the present invention;

[0086] Fig.13 is a three-dimensional schematic diagram of a sample extraction mechanism according to an embodiment of the present invention;

[0087] Fig.14 is a three-dimensional schematic diagram of a reaction chamber body according to an embodiment of the present invention;

[0088] Fig.15 1 is a three-dimensional schematic diagram of a membrane breaking component and a PMT component according to an embodiment of the present invention;

[0089] Fig.16 3D is a schematic three-dimensional diagram of a PMT assembly according to an embodiment of the present invention.

[0090] Description of main component symbols:

[0091] Multi-channel multi-test POCT fully automatic chemiluminescence equipment-100;

[0092] Mounting frame - 10;

[0093] Multiple test reagent strip-20; reagent strip body-21; liquid sealing area-211; special liquid area-2111; common liquid area-2112; handle-22; sample hole-23; tip head-24; disposable magnetic separation sleeve-25;

[0094] Reaction chamber assembly-30; guide rail-31; reaction chamber body-32; accommodating groove-33; fourth driving element-34; mounting seat-35; first driven pulley-36;

[0095] Multi-channel multi-joint inspection parallel pre-processing device-40; gantry-41; first driving element-411; activity space-412; transmission plate-413; first slide rail-414; second slide rail-415; sample extraction mechanism-42; second mounting frame-421; second slide seat-4211; third driving element-422; extraction component-423; injection device-4231; second loading head-4232; second push plate-4233; piston rod-4234; push rod-4235; elastic element-4236; separation plate-4237; sample pre-processing mechanism-43; first mounting frame-431; first slide seat-4311; second driving element-432; pre-processing component-433; magnetic rod-4331; magnetic rod device-4332; first loading head-4333; first push plate-4334; connecting rod-4335;

[0096] Membrane breaking component-50; seventh driving element-51; fifth mounting frame-52; membrane breaking head-53;

[0097] PMT assembly-60; mounting bracket-61; third mounting frame-62; fourth mounting frame-63; PMT module-64; fifth driving element-65; sixth driving element-66; second driven pulley-67; second synchronous belt pressure plate-68. DETAILED DESCRIPTION

[0098] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. In addition, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0099] In the description of the present invention, it is necessary to understand that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0100] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0101] The disclosure below provides many different embodiments or examples to realize different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the examples of various specific processes and materials provided by the present invention, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0102] See also Figures 1 to 7 and Fig.12 The multi-channel multi-joint detection POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention comprises:

[0103] Mounting frame 10;

[0104] A reaction chamber assembly 30 disposed on the mounting frame 10 and used for loading the multiple test strip 20, the reaction chamber assembly 30 can reciprocate along the length direction of the mounting frame 10, the multiple test strip 20 is used to detect at least two markers, the multiple test strip 20 includes a liquid sealing area 211, and the liquid sealing area 211 includes a common liquid area 2112 and a dedicated liquid area 2111 distributed along the length direction of the multiple test strip 20;

[0105] A multi-channel multi-joint test parallel pre-processing device 40 is arranged on the mounting frame 10 and above the reaction chamber assembly 30. The multi-channel multi-joint test parallel pre-processing device 40 includes at least two rows of magnetic bars 4331 arranged side by side along the movement direction of the reaction chamber assembly 30. Each row of magnetic bars 4331 has at least two magnetic bars. The at least two rows of magnetic bars 4331 are used to transfer magnetic particles in adjacent holes of the multi-joint test reagent strip 20 in the liquid sealing area 211.

[0106] A membrane breaking assembly 50 disposed on the mounting frame 10 and located at the rear end of the multi-channel multi-joint detection parallel pre-processing device 40, the membrane breaking assembly 50 is used to break the sealing film of the common liquid area 2112; and

[0107] The PMT assembly 60 is arranged on the mounting frame 10 and is located at the rear end of the membrane breaking assembly 50 and above the reaction chamber assembly 30. The reaction chamber assembly 30 is used to move the multi-test reagent strip 20 to the PMT assembly 60. The PMT assembly 60 is used to detect the luminescence value of the detection position of the multi-test reagent strip 20.

[0108] In the multi-channel multi-test POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention, the multi-channel multi-test parallel pre-processing device 40 includes at least two rows of magnetic bars 4331 for transferring magnetic particles, and there are at least two magnetic bars 4331 in each row, that is, the multi-channel multi-test parallel pre-processing device 40 can simultaneously transfer the magnetic particles in at least two adjacent reagent wells on a single multi-test reagent strip 20, and transfer the magnetic particles in adjacent reagent wells of at least two multi-test reagent strips 20 arranged in parallel, thereby realizing the analysis and detection of at least two markers, realizing multi-test while realizing multi-channel parallel processing, reducing the risk of cross infection, shortening the time for transferring magnetic particles, and ensuring the analysis efficiency of the equipment.

[0109] Furthermore, based on the structure of the device and in combination with the special design of the multi-test reagent strip 20, the operation of breaking the sealing film of the multi-test reagent strip 20 does not need to be completely performed by the multi-channel multi-test parallel pre-treatment device 40, but the sealing film of the common liquid area 2112 can be broken by the membrane breaking component 50 at the rear end. The reaction chamber component 30 does not need to move the multi-test reagent strip 20 for a long distance to achieve targeted membrane breaking, thereby reducing the repeated and long-distance movement of the reaction chamber component 20 and the repeated membrane breaking work of the multi-channel multi-test parallel pre-treatment device 40. While controlling the volume of the multi-channel multi-test POCT fully-automatic chemiluminescence device 100, efficient detection of multiple detection items can be achieved.

[0110] Specifically, the multi-channel multi-test POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention is roughly rectangular in shape, and the mounting frame 10 is the basic structure of the multi-channel multi-test POCT fully automatic chemiluminescence device 100. The mounting frame 10 may include a base plate, multiple side plates and a top plate arranged on the base plate, etc. The mounting frame 10 surrounded by the base plate, multiple side plates and the top plate is also roughly rectangular in shape.

[0111] The mounting frame 10 is used to carry and install the above-mentioned reaction chamber assembly 30, the multi-channel multi-inspection parallel pre-processing device 40, the membrane breaking assembly 50, the PMT assembly 60 and other components. The above-mentioned reaction chamber assembly 30, the multi-channel multi-inspection parallel pre-processing device 40, the membrane breaking assembly 50, the PMT assembly 60 and other components are arranged in the space of the mounting frame 10. The mounting frame 10 provides stable support for the above-mentioned components and protects the above-mentioned components from interference from external impurities, water vapor, etc.

[0112] A plurality of parallel accommodating grooves 33 may be formed on the reaction chamber assembly 30, and the accommodating grooves 33 extend along the length direction of the reaction chamber assembly 30. The multi-test reagent strips 20 are loaded in the accommodating grooves 33. The plurality of accommodating grooves 33 may accommodate a plurality of multi-test reagent strips 20, that is, the reaction chamber assembly 30 may drive the plurality of multi-test reagent strips 20 to move in the multi-channel multi-test POCT fully automatic chemiluminescence device 100, thereby enabling the multi-channel multi-test POCT fully automatic chemiluminescence device 100 to perform multi-channel detection and analysis on a plurality of test strips in sequence.

[0113] See also Figure 4 and Figure 5 Furthermore, the multiple test reagent strip 20 comprises:

[0114] The reagent strip body 21, the liquid sealing area 211 is provided on the reagent strip body 21;

[0115] A handle 22 disposed at one end of the test strip body 21; and

[0116] A sample hole 23, a tip 24, at least two disposable magnetic separation sleeves 25, a dedicated liquid area 2111 and a common liquid area 2112 are arranged on the reagent strip body 21 in sequence from the handle 22 to the other end of the reagent strip body 21;

[0117] The dedicated liquid area 2111 includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area 2112 includes a cleaning liquid and a luminescent substrate liquid.

[0118] In the embodiment of the present invention, the multiple test strip 20 is a disposable consumable and can be directly discarded and destroyed after use. The multiple test strip 20 is generally in the shape of a long strip, and a handle 22 may be provided at one end thereof. The handle 22 may be provided with anti-slip patterns to increase the friction between the multiple test strip 20 and the operator's fingers, so that the operator can hold it tightly.

[0119] A sample hole 23, a tip hole, at least two disposable magnetic separation sleeve holes, at least two magnetic labeling ligand holes, at least two enzyme labeling ligand holes, multiple cleaning liquid holes and multiple substrate reading holes (i.e., the above-mentioned detection positions) are sequentially arranged from one end of the handle 22 to the other end of the multi-test reagent strip 20. The magnetic labeling ligand hole and the enzyme labeling ligand hole constitute a dedicated liquid area 2111, the cleaning liquid hole and the substrate reading hole constitute a common liquid area 2112, and the dedicated liquid area 2111 and the common liquid area 2112 constitute a liquid sealing area 211.

[0120] The sample hole 23 is used to add a blood sample, the tip hole is provided with a tip head 24, the disposable magnetic separation sleeve hole is provided with a disposable magnetic separation sleeve 25, the magnetic labeling ligand hole contains a magnetic labeling ligand, and the enzyme labeling ligand hole contains an enzyme labeling ligand, wherein the ligand includes but is not limited to a hapten, an antigen, a monoclonal antibody, a polyclonal antibody and a nucleic acid ligand. The cleaning liquid hole contains a cleaning liquid, and the substrate reading hole contains a substrate reading. The number of rows of the magnetic rod 4331 is equal to the number of the disposable magnetic separation sleeve hole, the magnetic labeling ligand hole, the enzyme labeling ligand hole and the substrate reading hole.

[0121] In addition, after the corresponding reagents are packaged in the corresponding holes of the multiple test strip 20, the surface of the multiple test strip 20 can be heat-sealed with a film to prevent the reagents in each hole from leaking or being contaminated, and to facilitate the storage and transportation of the multiple test strip 20.

[0122] The tip head 24 is a hollow structure with a sharp end and a perforation on the end, so that the tip head 24 can be used to transfer samples or reagents, and can also be used to break the sealing film on each hole position. The disposable magnetic separation sleeve 25 can be used to adsorb, mix, clean and transfer magnetic particles. The cleaning liquid hole can be used to clean the magnetic particles. The substrate reading hole is used to perform a chemiluminescent reaction and read the luminescence value.

[0123] In the embodiment of the present invention, the dedicated liquid area 2111 can be understood as components directly related to the detection items (such as magnetic bead-labeled ligands, enzyme-labeled ligands and pretreatment liquids, etc.), where the ligands include haptens, antigens, antibodies and nucleic acid probes, etc., and the common liquid area 2112 can be understood as components that can be shared between detection items (such as cleaning liquid and luminescent liquid, etc.).

[0124] In the common liquid area 2112, even if the membrane breaking component 50 is contaminated with liquid in one hole during the previous membrane breaking process and then contaminates the liquid into other holes, it will not have a significant impact on the detection result. Therefore, the membrane breaking component 50 is designed in the embodiment of the present invention to specifically break the sealing film of the common liquid area 2112, reduce the membrane breaking work of the multi-channel multi-inspection parallel pre-treatment device 40, shorten the moving distance of the reaction chamber component 30, control the equipment volume and improve the multi-project analysis efficiency of the equipment.

[0125] Since the reaction chamber assembly 30 is arranged on the bottom plate of the mounting frame 10, the PMT assembly 60 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT assembly 60 is located relatively above the reaction chamber assembly 30. To ensure that the PMT assembly 60 can detect the luminescence values ​​of all the multi-test reagent strips 20 in the reaction chamber assembly 30, the PMT assembly 60 can move up, down, left and right in the mounting frame 10, that is, it can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 10), so as to approach or move away from the multi-test reagent strip 20 and move back and forth between multiple multi-test reagent strips 20.

[0126] Similarly, the multi-channel multi-test parallel pre-treatment device 40 can also be arranged above the bottom plate through a bracket and other structures, that is, the multi-channel multi-test parallel pre-treatment device 40 is located relatively above the reaction chamber assembly 30. To ensure that the multi-channel multi-test parallel pre-treatment device 40 can pre-treat all the multi-test reagent strips 20 in the reaction chamber assembly 30, the multi-channel multi-test parallel pre-treatment device 40 can also move up and down in the installation frame 10, that is, move in the vertical direction, so as to approach or move away from the multi-test reagent strip 20 to transfer samples or reagents, break the sealing film on the hole position of the multi-test reagent strip 20, and adsorb, mix, wash and transfer magnetic particles.

[0127] In an embodiment of the present invention, the multi-channel multi-test parallel pre-processing device 40 may include two parts of the structure, one part of the structure is used to combine with the tip head 24 to transfer samples or reagents and break the sealing film of each hole, and the other part of the structure is used to combine with the disposable magnetic separation sleeve 25 to adsorb, mix, clean and transfer magnetic particles.

[0128] See also Figures 6 to 13 Furthermore, the multi-channel multi-joint inspection parallel pre-processing device 40 includes:

[0129] A gantry 41 is disposed on the bottom plate of the mounting frame 10, and a first driving element 411 is disposed on the top of the gantry 41;

[0130] A sample extraction mechanism 42 is disposed on the gantry 41, and the sample extraction mechanism 42 is in driving connection with the first driving element 411, and can be raised and lowered under the driving of the first driving element 411 to suck and discharge the sample on the multiple test reagent strip 20;

[0131] The sample pre-processing mechanism 43 disposed on the gantry 41 is transmission-connected to the first driving element 411 and can be raised and lowered under the drive of the first driving element 411 . At least two rows of magnetic bars 4331 are disposed on the sample pre-processing mechanism 43 to transfer the magnetic particles on the multiple-test reagent strip 20 .

[0132] Specifically, the gantry 41 can be made of metal materials, such as stainless steel, iron, aluminum and various alloys, which have high strength and can improve the service life of the multi-channel pre-processing device 40. The gantry 41 spans the width direction of the mounting frame 10, so that the sample extraction mechanism 42 and the sample pre-processing mechanism 43 can span the top of the reaction chamber assembly 30 to achieve multi-channel parallel pre-processing.

[0133] In the embodiment of the present invention, the first driving element 411 can be a screw motor, which has high movement accuracy and more accurate and stable position adjustment. The first driving element 411 arranged on the top of the gantry 41 drives the sample extraction mechanism 42 and the sample pre-treatment mechanism 43 to rise and fall on the gantry 41, so that the sample extraction mechanism 42 and the sample pre-treatment mechanism 43 are close to or away from the multi-test reagent strip 20, so that the sample extraction mechanism 42 cooperates with the tip head 24 on the multi-test reagent strip 20 to achieve functions such as membrane breaking, sample transfer or reagent transfer, and the sample pre-treatment mechanism 43 cooperates with the disposable magnetic separation sleeve 25 on the multi-test reagent strip 20 to achieve adsorption, mixing, cleaning and transfer of magnetic particles.

[0134] In addition, the sample pre-processing mechanism 43 and the sample extraction mechanism 42 are located on opposite sides of the gantry 41 , such as the sample pre-processing mechanism 43 is located on one side of the gantry 41 close to the PMT assembly 60 , and the sample extraction mechanism 42 is located on the other side of the gantry 41 .

[0135] In this way, it is possible to avoid placing the sample pretreatment mechanism 43 and the sample extraction mechanism 42 on the same side of the gantry 41, which would cause crowded space and heavy load on one side of the gantry 41, and cause inconvenient operation and unstable structure of the gantry 41. In addition, the sample extraction mechanism 42 and the sample pretreatment mechanism 43 can be made to correspond to reagent holes with different functions on the multi-test reagent strip 20 respectively. For example, the front section of the multi-test reagent strip 20 requires more participation of the sample extraction mechanism 42, while the rear section requires more participation of the sample pretreatment mechanism 43. This can further improve the pretreatment speed of the multi-channel multi-test parallel pretreatment device 40 on the multi-test reagent strip 20.

[0136] See also Figures 6 to 12 Furthermore, the sample pre-processing mechanism 43 includes:

[0137] A first mounting frame 431 is disposed on the gantry 41 and is in driving connection with the first driving element 411. The first driving element 411 can drive the first mounting frame 431 to rise and fall;

[0138] a second driving element 432 disposed on the first mounting frame 431; and

[0139] The pre-processing component 433 is disposed on the first mounting frame 431 and is transmission-connected to the second driving element 432 . The second driving element 432 can drive the pre-processing component 433 to move in a vertical direction to transfer magnetic particles.

[0140] Specifically, the first driving element 411 can drive the first mounting frame 431 to rise and fall, thereby driving the sample pre-processing mechanism 43 to rise and fall, so as to perform corresponding treatments such as transferring magnetic particles on the multiple test reagent strip 20. The first mounting frame 431 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The second driving element 432 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting of the pre-processing component 433.

[0141] The pre-processing component 433 is arranged on the vertical extension plate, and the second driving element 432 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the pre-processing component 433. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the second driving element 432 can make the pre-processing component 433 move smoothly and accurately in the vertical direction through threaded driving, thereby smoothly and accurately adsorbing the magnetic particles and then transferring the magnetic particles.

[0142] Furthermore, in order to ensure that the pre-processing component 433 is smoothly raised and lowered on the first mounting frame 431, a slide rail extending in the vertical direction can be set on the first mounting frame 431, and a slider adapted to the slide rail can be set on the first push plate 4334. The stable movement of the pre-processing component 433 on the first mounting frame 431 is achieved through the cooperation of the slide rail and the slider.

[0143] In addition, a first detector (such as a photoelectric switch) can be arranged on one side of the top of the gantry 41, and a first induction member (such as a baffle) can be arranged on one side of the top of the first mounting frame 431. The first induction member can generate induction or disconnect induction with the first detector as the first mounting frame 431 rises and falls. When the first mounting frame 431 drives the first induction member to move to the first detector to disconnect the induction, it indicates that the sample pre-processing mechanism 43 has moved to the set height. At this time, the power supply of the first driving element 411 can be disconnected to avoid overload damage to the first driving element 411, and also save power consumption.

[0144] Furthermore, a first slide seat 4311 may be provided on the side of the first mounting frame 431 facing the gantry 41 , and a first slide rail 414 extending along the height direction of the gantry 41 may be provided on the side of the gantry 41 facing the first mounting frame 431 , and the first slide seat 4311 is slidably connected to the first slide rail 414 .

[0145] The first slide 4311 and the first slide rail 414 are two groups, which are respectively arranged on the left and right sides of the gantry 41 and the first mounting frame 431. Through the cooperation of the two groups of first slides 4311 and the first slide rails 414, it can be ensured that the first driving element 411 drives the first mounting frame 431 on the gantry 41 to rise and fall smoothly, thereby ensuring that the sample extraction mechanism 42 rises and falls smoothly and accurately.

[0146] In the embodiment of the present invention, the sample extraction mechanism 42 is opposite to the sample pre-processing mechanism 43 on the gantry 41, and the sample extraction mechanism 42 is located in front of the sample pre-processing mechanism 43. The first driving element 411, the second driving element 432 and the third driving element 422 are linearly arranged on the top of the gantry 41, so that the top structure distribution of the multi-channel multi-joint inspection parallel pre-processing device 40 is regular, and the three driving elements are basically concentrated in the middle position of the gantry 41 when exerting force, so that the gantry 41 is evenly stressed and not prone to shaking or deviation.

[0147] See also Fig. 9 and Fig.12 , further, the pre-processing component 433 includes:

[0148] A magnetic rod device 4332 is arranged on the first mounting frame 431, wherein a plurality of movable through holes are formed in the magnetic rod device 4332, and a first loading head 4333 for loading the disposable magnetic separation sleeve 25 is arranged at the bottom of the magnetic rod device 4332, wherein the first loading head 4333 is connected to the movable through holes;

[0149] a first push plate 4334 disposed above the magnetic bar device 4332, the first push plate 4334 being drivingly connected to the second driving element 432; and

[0150] A plurality of connecting rods 4335 are arranged on the first pushing plate 4334, and at least two rows of magnetic rods 4331 are arranged one by one on the free ends of the plurality of connecting rods 4335. The second driving element 432 can drive the first pushing plate 4334 to drive the magnetic rods 4331 to rise and fall in the corresponding movable through holes so as to be separated from the first loading head 4333 or pass through the first loading head 4333.

[0151] Specifically, the magnetic bar device 4332 is roughly in the shape of a cuboid and is distributed along the width direction of the first mounting frame 431 , so that the movable through holes therein can be distributed in the width direction of the pre-processing component 433 to correspond to the location of the multiple test reagent strip 20 .

[0152] When the disposable magnetic separation sleeve 25 needs to be loaded, the first driving element 411 drives the first mounting frame 431 to descend to the first loading head 4333 to contact the disposable magnetic separation sleeve 25 for loading. The two are interference fit, thereby ensuring the stability of the disposable magnetic separation sleeve 25 loaded on the first loading head 4333 and facilitating separation. The first loading head 4333 is connected to the movable through hole, so that the movable through hole is connected to the disposable magnetic separation sleeve 25. When the second driving element 432 drives the connecting rod 4335 to drive the magnetic rod 4331 to pass through the first loading head 4333 to extend into the disposable magnetic separation sleeve 25, the magnetic particles can be adsorbed by the disposable magnetic separation sleeve 25.

[0153] When the disposable magnetic separation sleeve 25 needs to be separated, the second driving element 432 is controlled to drive the magnetic bar 4331 to descend until it contacts the bottom end of the disposable magnetic separation sleeve 25, and the disposable magnetic separation sleeve 25 can be withdrawn from the first loading head 4333. When the second driving element 432 drives the connecting rod 4335 to drive the magnetic bar 4331 to separate from the first loading head 4333 and separate from the disposable magnetic separation sleeve 25, the magnetic field generated by the magnetic bar 4331 disappears, and the magnetic particles can be separated from the disposable magnetic separation sleeve 25 to achieve transfer.

[0154] Based on the design of at least two rows of magnetic rods 4331 in the pre-treatment component 433, the pre-treatment component 433 can be loaded with at least two rows of disposable magnetic separation sleeves 25 at a time, and the magnetic particles in at least two reagent wells can be transferred at a time through at least two rows of disposable magnetic separation sleeves 25. This can not only improve the transfer speed of the magnetic particles to ensure the analysis efficiency of the equipment, but also realize the multi-detection function of the equipment.

[0155] In addition, based on the transfer of magnetic particles, the pre-treatment component 433 combined with the disposable magnetic separation sleeve 25 can also be used to transfer the magnetic particles to the reagent for reaction mixing, or to separate the magnetic particles in the reaction solution into the cleaning solution, or to transfer the magnetic particles to the substrate reading for reaction and complete luminescence detection.

[0156] The transmission shaft of the second driving element 432 extends downward through the top of the first mounting frame 431 and the first push plate 4334. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the first push plate 4334 can be fixed on the fixing piece. When the transmission shaft of the second driving element 432 moves, the first push plate 4334 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the magnetic rod 4331.

[0157] Alternatively, a screw hole may be directly set on the first push plate 4334, and a thread may be set on the transmission shaft of the second driving element 432. The transmission shaft is threadedly connected to the first push plate 4334 (screw hole). This can ensure the stability of the connection between the two, and the second driving element 432 can also drive the first push plate 4334 to rise and fall smoothly through threaded driving.

[0158] See also Fig. 9 and Fig.12 Furthermore, the magnetic bars 4331 are arranged in multiple rows, and the multiple rows of magnetic bars 4331 are evenly spaced along the width direction of the first push plate 4334. The number of rows of magnetic bars 4331 is equal to the number of substrate reading holes to achieve detection of multiple items, that is, to achieve multi-item detection.

[0159] There are multiple magnetic bars 4331 in each row, and the multiple magnetic bars 4331 in each row are evenly spaced along the length direction of the first push plate 4334. The number of magnetic bars 4331 in each row is equal to the number of multi-test reagent strips 20, thereby realizing multi-channel parallel processing of multiple multi-test reagent strips 20.

[0160] In the embodiment of the present invention, there are three rows of magnetic rods 4331, which can realize the detection of three items. The space occupied by the three rows of magnetic rods 4331 is not too large, and three items of detection can be realized. The multi-channel multi-detection POCT fully automatic chemiluminescence device 100 can be realized while controlling the volume.

[0161] Of course, in other embodiments, the magnetic bars 4331 can also be arranged in 2 rows, 4 rows or even more rows to detect different numbers of items.

[0162] The sample pre-processing mechanism 43 of the embodiment of the present invention can reciprocate the magnetic attraction by the lifting and lowering drive of the magnetic rod 4331 by the second driving element 432, and the efficiency of magnetic separation is higher. The multi-channel parallel separation process further improves the separation and transfer efficiency of magnetic particles. At the same time, the reciprocating motion of the disposable magnetic separation sleeve 25 can also be achieved by the second driving element 432, and the mixing of the reaction solution and the resuspension of the cleaning solution can also be completed.

[0163] Exemplarily, the process of transferring magnetic particles by the sample pre-processing mechanism 43 is roughly as follows:

[0164] After the sample is injected into the corresponding reagent hole of the multi-test reagent strip 20, the reaction chamber assembly 30 drives the multi-test reagent strip 20 to move to the corresponding position, so that the sample pre-treatment mechanism 43 is located directly above the disposable magnetic rod 4331 set. At this time, the first driving element 411 drives the first mounting frame 431 to descend a certain height until the disposable magnetic rod 4331 set is loaded on the first loading head 4333. The first driving element 411 drives the first mounting frame 431 to rise, and the disposable magnetic rod 4331 set is driven by the first loading head 4333 to rise to a certain height.

[0165] Afterwards, the reaction chamber assembly 30 moves until the sample pre-treatment assembly 433 loaded with the disposable magnetic rod 4331 set moves to the top of the corresponding hole position of the multi-test reagent strip 20, and the second driving element 432 drives the magnetic rod 4331 to descend until the magnetic rod 4331 contacts the bottom of the disposable magnetic separation sleeve 25. At this time, the first driving element 411 drives the first mounting frame 431 to descend to a certain height, so that the disposable magnetic rod 4331 set extends into the liquid containing magnetic particles (such as the magnetic labeled ligand mentioned above) until the disposable magnetic rod 4331 set contacts the bottom of the magnetic labeled ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve 25, and the magnetic particles can be fully adsorbed by slowly lifting and lowering for multiple times.

[0166] After the adsorption of the magnetic particles is completed, the first driving element 411 is controlled to drive the first mounting frame 431 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 25. The reaction chamber assembly 30 is controlled to move until the disposable magnetic separation sleeve 25 is located above the cleaning liquid. The first driving element 411 drives the first mounting frame 431 to descend until the disposable magnetic separation sleeve 25 extends into the cleaning liquid. After that, the second driving element 432 drives the magnetic rod 4331 to rise from the disposable magnetic separation sleeve 25 to make the magnetic field disappear, and the magnetic particles are separated from the outer wall of the disposable magnetic separation sleeve 25 and fall off, and enter the cleaning liquid.

[0167] In order to speed up the separation process of the magnetic particles, the first driving element 411 can drive the first mounting frame 431 to rise and fall repeatedly at different frequencies, so that the magnetic particles repeatedly move in the cleaning solution, thereby ensuring that the magnetic particles and the cleaning solution are fully mixed and suspended. After the magnetic particles are completely separated from the outer wall of the disposable magnetic separation sleeve 25, the first driving element 411 drives the first mounting frame 431 to rise to the initial height, completing the separation, cleaning and mixing operation of the magnetic particles. If multiple magnetic separation and cleaning are required, the above operation can be repeated.

[0168] Similarly, if it is necessary to transfer the magnetic particles to other hole positions, just control the first driving element 411 to drive the first mounting frame 431 to descend until the disposable magnetic separation sleeve 25 extends to the bottom of the corresponding liquid surface, and then control the second driving element 432 to drive the magnetic rod 4331 to descend until it contacts the bottom end of the disposable magnetic separation sleeve 25, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 25, and control the first driving element 411 to drive the first mounting frame 431 to rise.

[0169] Afterwards, the reaction chamber assembly 30 is controlled to move until the disposable magnetic separation sleeve 25 adsorbed with magnetic particles moves to the top of the target hole, and then the first driving element 411 is controlled to drive the first mounting frame 431 to descend until the disposable magnetic separation sleeve 25 extends into the target liquid. At this time, the second driving element 432 is controlled to drive the magnetic rod 4331 to rise to make the magnetic field disappear, and the magnetic particles can be gradually separated into the target liquid. The first driving element 411 can be controlled to repeatedly drive the first mounting frame 431 to rise and fall, so that the disposable magnetic separation sleeve 25 can repeatedly move in the target liquid to accelerate the separation of the magnetic particles.

[0170] See also Figures 6 to 11 and Fig.13 Furthermore, the sample extraction mechanism 42 includes:

[0171] A second mounting frame 421 is disposed on the gantry 41 and is transmission-connected to the first driving element 411. The first driving element 411 can drive the second mounting frame 421 to rise and fall;

[0172] a third driving element 422 disposed on the second mounting frame 421; and

[0173] The extraction component 423 is disposed on the second mounting frame 421 and is drivingly connected to the third driving element 422. The third driving element 422 can drive the extraction component 423 to rise and fall to suck and discharge the sample.

[0174] Specifically, the first driving element 411 can drive the second mounting frame 421 to rise and fall, thereby driving the sample extraction mechanism 42 to rise and fall, so as to perform corresponding processing such as aspirating and spitting samples on the multiple test strip 20. The second mounting frame 421 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The third driving element 422 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting and lowering of the extraction component 423.

[0175] The extraction component 423 is arranged on the vertical extension plate, and the third driving element 422 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the extraction component 423. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the third driving element 422 can make the extraction component 423 move smoothly and accurately in the vertical direction through threaded driving, so as to smoothly and accurately suck out the sample after contacting with the sample.

[0176] In addition, a second detector (such as a photoelectric switch) can be set on one side of the top of the gantry 41, and a second sensing element (such as a baffle) can be set on one side of the top of the second mounting bracket 421. The second sensing element can generate or disconnect induction with the second detector as the second mounting bracket 421 rises and falls.

[0177] When the second mounting bracket 421 drives the second sensing element to move to the second detector to disconnect the sensing, it indicates that the sample extraction mechanism 42 has moved to the set height. At this time, the power supply of the first driving element 411 can be disconnected to avoid overload and damage to the first driving element 411 and save power consumption.

[0178] Furthermore, a second slide seat 4211 may be provided on the side of the second mounting frame 421 facing the gantry 41 , and a second slide rail 415 extending along the height direction of the gantry 41 may be provided on the side of the gantry 41 facing the second mounting frame 421 , and the second slide seat 4211 is slidably connected to the second slide rail 415 .

[0179] Moreover, the second mounting frame 421 and the second slide 4211 and the second slide rail 415 on the gantry 41 are two groups, which are respectively arranged on the left and right sides of the gantry 41 and the second mounting frame 421. In this way, through the cooperation between the two groups of second slides 4211 and the second slide rail 415, it can be ensured that the first driving element 411 drives the second mounting frame 421 on the gantry 41 to rise and fall smoothly, thereby ensuring that the sample extraction mechanism 42 rises and falls smoothly and accurately, and ensuring the stable operation of the equipment.

[0180] See also Fig.13 , further, the extraction component 423 includes:

[0181] An injection device 4231 is arranged on the second mounting frame 421, wherein a plurality of injection cavities are formed in the injection device 4231, and a plurality of second loading heads 4232 for loading the tip head 24 are arranged at the bottom of the injection device 4231, and the plurality of second loading heads 4232 are connected to the plurality of injection cavities in a one-to-one correspondence;

[0182] A second push plate 4233 disposed above the injection device 4231, the second push plate 4233 is drivingly connected to the third driving element 422; and

[0183] A plurality of piston rods 4234 are disposed on the second push plate 4233 , and the piston rods 4234 are movably and hermetically connected to the syringe cavity. The third driving element 422 can drive the second push plate 4233 to drive the piston rods 4234 to move up and down in the syringe cavity to perform a suction and exhalation action.

[0184] Specifically, the injection device 4231 is roughly in the shape of a rectangular parallelepiped, and is distributed along the width direction of the second mounting frame 421, so that the injection cavity therein can be distributed in the width direction of the extraction assembly 423 to correspond to the location of the multi-test reagent strip 20. The injection device 4231 also has a certain height to ensure that the space of the injection cavity is large enough, so that the piston rod 4234 can generate a sufficiently large suction and discharge force when moving in the injection cavity.

[0185] The second loading head 4232 and the tip head 24 are in interference fit, thereby ensuring the stability of the tip head 24 loaded on the second loading head 4232, and also facilitating the tip head 24 to be withdrawn by pushing. When the first driving element 411 drives the second mounting frame 421 to drive the extraction assembly 423 to descend, the corresponding sealing film on the multi-test reagent strip 20 can be broken by the tip head 24 loaded on the second loading head 4232. The second loading head 4232 is connected to the syringe cavity, which makes the syringe cavity connected to the tip head 24. When the piston rod 4234 is pushed up and down in the syringe cavity, the sample can be sucked and discharged through the tip head 24.

[0186] The transmission shaft of the third driving element 422 extends downward through the top of the second mounting frame 421 and the second push plate 4233. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the second push plate 4233 can be fixed on the fixing piece. When the transmission shaft of the third driving element 422 moves, the second push plate 4233 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the piston rod 4234.

[0187] Alternatively, a screw hole may be provided on the second push plate 4233, and a thread may be provided on the transmission shaft of the third driving element 422, so that the transmission shaft is threadedly connected to the second push plate 4233. This can ensure the stability of the connection between the two, and the third driving element 422 can also drive the second push plate 4233 to rise and fall by threaded driving.

[0188] In this embodiment, the end of the piston rod 4234 in the syringe cavity can be sealed with the syringe cavity by a sealing ring (such as a rubber ring or a plastic ring, etc.). When the piston rod 4234 is driven upward by the second push plate 4233 and rises in the syringe cavity, negative pressure is generated in the syringe cavity to make the tip head 24 absorb the sample, and when the piston rod 4234 is pushed downward by the second push plate 4233 and descends in the syringe cavity, positive pressure is generated in the syringe cavity to make the tip head 24 spit out the sample.

[0189] Furthermore, in order to ensure that the second push plate 4233 can stably drive the piston rod 4234 to rise and fall, a slide rail extending in the vertical direction is provided on the injection device 4231, and a slider adapted to the slide rail is provided on the second push plate 4233, and the second push plate 4233 can stably move relative to the second mounting frame 421 through the cooperation of the slide rail and the slider, thereby ensuring the stable driving of the piston rod 4234. The slide rail and the slider are two sets, which are respectively provided on the left and right sides of the sample extraction mechanism 42, further ensuring the stable rise and fall of the second push plate 4233.

[0190] Furthermore, a photoelectric switch can be arranged on the top of the second mounting frame 421, and a baffle can be arranged on the corresponding side of the second push plate 4233. When the second push plate 4233 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the second push plate 4233 has moved to the set height, that is, it indicates that the piston rod 4234 has been reset. At this time, the power supply of the third driving element 422 can be disconnected to prevent the third driving element 422 from being overloaded and damaged.

[0191] Please combine Fig. 9 and Fig.13 In the embodiment of the present invention, multiple syringe cavities are evenly spaced along the length direction of the injection device 4231; multiple second loading heads 4232 are evenly spaced along the length direction of the injection device 4231; multiple piston rods 4234 are evenly spaced along the length direction of the second push plate 4233; that is, multiple piston rods 4234, multiple syringe cavities and multiple piston rods 4234 correspond one to one, thereby realizing multi-channel parallel processing of multiple multi-test reagent strips 20.

[0192] Please continue reading Fig.13 Furthermore, the sample extraction mechanism 42 also includes:

[0193] A push rod 4235 is lifted and lowered to penetrate the injection device 4231, and a top end of the push rod 4235 is spaced apart from the second push plate 4233;

[0194] An elastic element 4236 is sleeved on a push rod 4235 in the injection device 4231, and the elastic element 4236 is stretched or compressed simultaneously when the push rod 4235 is lifted or lowered relative to the injection device 4231; and

[0195] A separation plate 4237 is provided at the bottom of the injection device 4231 , and the second loading head 4232 passes through the separation plate 4237 . The bottom end of the push rod 4235 is connected to the separation plate 4237 , and the push rod 4235 can drive the separation plate 4237 to rise and fall relative to the second loading head 4232 .

[0196] In an embodiment of the present invention, a through hole is provided on the separation plate 4237, and the size of the through hole is smaller than the size of the connection between the tip head 24 and the second loading head 4232. Therefore, the tip head 24 loaded on the second loading head 4232 can be removed by setting the separation plate 4237.

[0197] Specifically, since the top end of the push rod 4235 is spaced from the second push plate 4233, when the second push plate 4233 is pushed down a certain height by the third driving element 422 to contact the top end of the push rod 4235, the second push plate 4233 pushes the push rod 4235 to descend in the injection device 4231, thereby pushing the separation plate 4237 located at the bottom of the injection device 4231 to descend and abut against the tip head 24, so as to push the tip head 24 to separate from the second loading head 4232.

[0198] After the tip 24 is separated, the third driving element 422 stops driving, and the elastic element 4236 stretches to generate an upward thrust on the push rod 4235, driving the separation plate 4237 to reset. The compression of the elastic element 4236 can provide a certain buffer force for the descent of the push rod 4235, so as to prevent the push rod 4235 from descending too fast and causing the tip 24 to be pressed and damaged, or the tip 24 is pressed on the multiple test strip 20, causing the multiple test strip 20 to deviate or shake.

[0199] In the embodiment of the present invention, there are two push rods 4235 and elastic elements 4236, which are respectively arranged on both sides of the injection device 4231 to ensure that the push rod 4235 pushes the separation plate 4237 smoothly, thereby ensuring the separation effect of the tip head 24, and ensuring the smooth resetting of the separation plate 4237 by the elastic element 4236.

[0200] Exemplarily, the process of the sample extraction mechanism 42 sucking and discharging the sample (and transferring / mixing the reagent) is roughly as follows:

[0201] The reaction chamber assembly 30 drives the multiple test reagent strip 20 to move to the corresponding position, and the first driving element 411 drives the second mounting frame 421 to descend until the second loading head 4232 cooperates and fixes with the tip head 24 on the multiple test reagent strip 20.

[0202] After the tip head 24 is loaded, the reaction chamber assembly 30 drives the multi-test reagent strip 20 to move until the tip head 24 moves to the top of the sample hole 23. At the same time, the third driving element 422 first drives the piston rod 4234 to descend a certain height or to the lowest point in the syringe cavity. Then, the first driving element 411 drives the second mounting frame 421 to descend a certain height until the tip of the tip head 24 extends into the sample. The third driving element 422 drives the piston rod 4234 to rise to absorb the sample through the tip head 24. Then, the first driving element 411 drives the second mounting frame 421 to rise so that the tip head 24 is separated from the sample liquid surface. The reaction chamber assembly 30 drives the multi-test reagent strip 20 to move until the tip head 24 with the sample absorbed moves to the top of the target hole.

[0203] The first driving element 411 drives the second mounting frame 421 to descend, driving the tip head 24 with the sample sucked to descend until its tip is inserted into the liquid surface of the reagent, and the third driving element 422 drives the piston rod 4234 to descend to inject the sample in the tip head 24 into the reagent. Afterwards, the first driving element 411 drives the second mounting frame 421 to rise until the tip head 24 is separated from the reagent, and the third driving element 422 drives the piston rod 4234 to rise to the original position to realize the suction and exhalation transfer of the sample, and then the tip head 24 is retracted into the tip head hole.

[0204] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0205] If multiple transfers are required, the tip 24 can be repeatedly loaded and the suction and injection actions can be repeated. In addition, the sample extraction mechanism 42 can also be used to mix the reagents, and the third driving element 422 is controlled to drive the piston rod 4234 to rise and fall repeatedly in the syringe cavity, so that the tip 24 repeatedly sucks and discharges under the reagent liquid surface, so that the reagents or samples that need to react can be fully mixed and reacted.

[0206] See also Figure 8 , Fig.10 and Fig.11 Furthermore, a movable space 412 is provided on the gantry 41, and a transmission shaft of the first driving element 411 passes through the movable space 412. A transmission plate 413 is sleeved on the transmission shaft, and a thread is provided on the transmission shaft, and a screw hole is provided on the transmission plate 413. Therefore, when the transmission shaft moves, the transmission plate 413 can be synchronously raised and lowered in the movable space 412 by thread transmission.

[0207] In addition, a first connecting portion is provided on the side of the first mounting frame 431 facing the gantry 41, and the first connecting portion is formed by a vertical extension plate of the first mounting frame 431 extending toward the gantry 41; a second connecting portion is provided on the side of the second mounting frame 421 facing the gantry 41, and the second extension portion is formed by a vertical extension plate of the second mounting frame 421 extending toward the gantry 41; both the first connecting portion and the second connecting portion are connected to the transmission plate 413 by fasteners (such as screws); therefore, when the transmission plate 413 is lifted or lowered along with the transmission shaft of the first driving element 411, the second mounting frame 421 and the first mounting frame 431 can be driven to lift or lower, thereby realizing the lifting or lowering of the sample extraction mechanism 42 and the sample pre-processing mechanism 43 on the gantry 41.

[0208] See also Figure 2 , Figure 3 and Fig.14 , further, the reaction chamber assembly 30 includes:

[0209] A guide rail 31 provided on the bottom plate of the mounting frame 10;

[0210] A reaction chamber body 32 is arranged on the guide rail 31, and a guide block is provided at the bottom of the reaction chamber body 32, which is slidably connected to the guide rail 31. The reaction chamber body 32 is provided with a plurality of evenly spaced receiving grooves 33 for loading the multi-test reagent strips 20, and the receiving grooves 33 extend along the length direction of the reaction chamber body 32;

[0211] A fourth driving element 34 is disposed on the bottom plate of the mounting frame 10 and located at the rear end of the guide rail 31, and a first driving pulley is disposed on the transmission shaft of the fourth driving element 34;

[0212] A mounting seat 35 is disposed on the bottom plate of the mounting frame 10 and located at the front end of the guide rail 31, and a first driven pulley 36 is disposed on the mounting seat 35. The first driving pulley is connected to the first driven pulley 36 through a belt; and

[0213] A first synchronous belt pressure plate is provided on one side of the reaction chamber body 32, and the first synchronous belt pressure plate is connected to the belt.

[0214] Specifically, the guide rail 31 extends along the length direction of the mounting frame 10. Through the sliding connection between the guide rail 31 and the guide block, the reaction chamber assembly 30 can move smoothly along the length direction of the mounting frame 10. The shape of the accommodating groove 33 is adapted to the shape of the multi-test reagent strip 20, so that the multi-test reagent strip 20 can be stably loaded on the reaction chamber assembly 30, maintaining stability during the movement and pre-treatment processes, avoiding deviation and shaking, and preventing the reagent from leaking from the multi-test reagent strip 20.

[0215] The fourth driving element 34 is located at the rear end of the mounting frame 10, and the mounting seat 35 is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the reaction chamber assembly 30 in the mounting frame 10 can be long enough to better cooperate with the movement of the multi-channel multi-inspection parallel pre-processing device 40.

[0216] The transmission structure composed of the first driving pulley, the belt, the first synchronous belt pressure plate and the first driven pulley 36 has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the guide rail 31, it can ensure that the reaction chamber assembly 30 moves stably and quickly in the installation frame 10, thereby improving the movement efficiency of the reaction assembly.

[0217] Furthermore, a photoelectric switch for detecting the position of the reaction chamber body 32 in real time may be provided on the bottom plate of the mounting frame 10, and a baffle may be provided on the reaction chamber body 32. When the reaction chamber body 32 drives the baffle to move to the corresponding position and the baffle reaches the photoelectric switch, causing the photoelectric switch to disconnect the sensing, it indicates that the reaction chamber assembly 30 has reached the set position. At this time, the power supply of the fourth driving element 34 can be disconnected to avoid overload and failure caused by continuous operation of the fourth driving element 34, thereby saving power consumption.

[0218] In addition, a heating module is also provided at the bottom of the reaction chamber body 32. The heating temperature of the heating module can be kept constant at human body temperature, i.e., 37°C. The temperature inside the reaction chamber body 32 is kept constant within a preset value range, thereby making the reagents in the multi-test reagent strip 20 meet the temperature conditions for chemiluminescence determination.

[0219] See also Figure 2 , Fig.15 and Fig.16 , further, the PMT assembly 60 includes:

[0220] A mounting bracket 61 provided on the bottom plate of the mounting frame 10;

[0221] A third mounting bracket 62 disposed on the mounting bracket 61;

[0222] a fourth mounting frame 63 disposed at the bottom of the third mounting frame 62;

[0223] A PMT module 64 disposed on a fourth mounting frame 63;

[0224] A fifth driving element 65 is disposed on the top of the third mounting frame 62 and is transmission-connected to the fourth mounting frame 63. The fifth driving element 65 can drive the fourth mounting frame 63 to move up and down to drive the PMT module 64 to move up and down;

[0225] A sixth driving element 66 and a second driven pulley 67 are respectively arranged on both sides of the top of the mounting bracket 61, a second driving pulley is arranged on the transmission shaft of the sixth driving element 66, and the second driving pulley is connected to the second driven pulley 67 through a belt; and

[0226] The second synchronous belt pressing plate 68 is arranged on the third mounting frame 62, and the second synchronous belt pressing plate 68 is connected to the belt.

[0227] In the embodiment of the present invention, the structure of the mounting bracket 61 can be similar to that of the gantry 41, and it also spans the width direction of the mounting frame 10, so that the PMT module 64 can move above the reaction chamber assembly 30 to achieve chemiluminescence detection. In addition, the mounting bracket 61 can also be made of metal materials, such as stainless steel, iron, aluminum, and various alloys, which have high strength and can increase the service life of the PMT assembly 60.

[0228] The third mounting frame 62 is used to mount the fifth driving element 65, and provides stable support for the fifth driving element 65, so that the fifth driving element 65 is stably located on the top of the mounting bracket 61. The fourth mounting frame 63 is used to mount the PMT module 64, and is connected to the fifth driving element 65 by transmission, so that the PMT module 64 can achieve lifting movement under the drive of the fifth driving element 65. The third mounting frame 62 is connected to the belt transmission, which can drive the fourth mounting frame 63 and the PMT module 64 thereon to move in the horizontal direction, and the combination of the fifth driving element 65 and the sixth driving element 66 can realize the up, down, left, and right movement of the PMT module 64 on the mounting bracket 61.

[0229] In an embodiment of the present invention, the fifth driving element 65 can be a screw motor, which drives the fourth mounting frame 63 to rise and fall through the fifth driving element 65 arranged on the top of the mounting bracket 61, so as to drive the PMT module 64 to rise and fall, so that the PMT component 60 can be close to or away from the multi-test reagent strip 20, and the screw motor has high movement accuracy, and the position adjustment of the PMT module 64 is more accurate and stable, so that the PMT component 60 can accurately and stably detect the luminescence value of the detection position on the multi-test reagent strip 20.

[0230] The sixth driving element 66 can be a stepper motor, which is located on one side of the top of the mounting bracket 61 (such as the right side), and the second driven pulley 67 is located on the other side of the top of the mounting bracket 61 (such as the left side), so that the connection between the two can cover the length direction of the mounting bracket 61, so that the movement of the PMT module 64 on the mounting bracket 61 can cover the width range of the mounting frame 10.

[0231] The transmission structure composed of the second active pulley, the belt, the second synchronous belt pressure plate 68 and the second driven pulley 67 has high transmission efficiency, simple structure, sufficient power, and the belt can increase the moving speed of the PMT module 64 and thus improve the detection efficiency, so that the PMT assembly 60 can quickly move and switch between each multi-detection reagent strip 20 in the reaction chamber assembly 30 to perform luminescence value detection respectively.

[0232] See also Figure 2 , Fig.15 and Fig.16 Furthermore, the membrane breaking component 50 includes:

[0233] a seventh driving element 51 disposed on the top of the mounting bracket 61;

[0234] a fifth mounting frame 52 disposed on the mounting bracket 61 and located below the seventh driving element 51 , the fifth mounting frame 52 being in driving connection with the seventh driving element 51 and being capable of being raised and lowered under the driving of the seventh driving element 51 ; and

[0235] A plurality of membrane breaking heads 53 are disposed at the bottom of the fifth mounting frame 52 , and the plurality of membrane breaking heads 53 are evenly spaced and distributed along the length direction of the fifth mounting frame 52 .

[0236] In the embodiment of the present invention, the membrane rupturing component 50 and the PMT component 60 share the mounting bracket 61, which can improve the utilization rate of the mounting bracket 61, control the internal volume of the device, and promote the miniaturization of the device. The membrane rupturing component 50 is located on the side of the mounting bracket 61 close to the multi-channel multi-joint test parallel pre-processing device 40, so that it is closer to the multi-joint test reagent strip 20, which can shorten the moving distance of the multi-joint test reagent strip 20, and rupture the membrane of the common liquid area 2112 more quickly, thereby improving the analysis efficiency of the device.

[0237] The seventh driving element 51 can be a screw motor, which drives the fifth mounting bracket 52 to rise and fall through the seventh driving element 51 disposed on the top of the mounting bracket 61 to drive the membrane breaking head 53 to rise and fall, so that the membrane breaking head 53 can be close to or away from the multi-test reagent strip 20, and then the sharp end of the membrane breaking head 53 is used to break the sealing film and switch the membrane breaking between different reagent holes. Moreover, the screw motor has high movement accuracy, and the position adjustment of the membrane breaking head 53 is more accurate and stable, so that the membrane breaking head 53 can accurately and stably break the sealing film of the common liquid area 2112, avoiding pressing the multi-test reagent strip 20 to cause shaking and dislocation.

[0238] The number of membrane rupturing heads 53 is the same as the number of multi-test reagent strips 20, so that all multi-test reagent strips 20 can be ruptured at the same time, thereby increasing the processing speed and thus increasing the analysis efficiency of the device. Furthermore, the membrane rupturing heads 53 can also be arranged in multiple rows, for example, the number of rows is the same as the number of reagent wells in the common liquid area 2112, so that the membrane rupturing assembly 50 only needs to be operated once to rupture all the sealing films of the common liquid area 2112, thereby increasing the membrane rupturing efficiency and thus increasing the analysis efficiency of the device.

[0239] In an embodiment of the present invention, the transmission shaft of the seventh driving element 51 extends downward through the top of the fifth mounting frame 52. A fixing member threadedly connected to the transmission shaft can be provided on the transmission shaft, and the fifth mounting frame 52 can be fixed on the fixing member. When the transmission shaft of the seventh driving element 51 moves, the fifth mounting frame 52 can be driven to rise and fall through the fixing member to realize the lifting and lowering of the membrane breaking head 53.

[0240] Alternatively, a screw hole may be directly set on the fifth mounting frame 52, and a thread may be set on the transmission shaft of the seventh driving element 51, so that the transmission shaft is threadedly connected to the fifth mounting frame 52 (screw hole). This can ensure the stability of the connection between the two, and the seventh driving element 51 can also drive the fifth mounting frame 52 to rise and fall smoothly by threaded driving.

[0241] In an embodiment of the present invention, the membrane breaking head 53 and the fifth mounting frame 52 can be detachably arranged. For example, the membrane breaking head 53 is mounted on the fifth mounting frame 52 by screws. This not only ensures the stability of the membrane breaking head 53 on the fifth mounting frame 52, but also facilitates disassembly and assembly, and is also convenient for replacement when the membrane breaking head 53 is damaged.

[0242] Furthermore, in order to ensure that the seventh driving element 51 drives the fifth mounting frame 52 to rise and fall stably, a slide rail extending in the vertical direction may be provided on the mounting frame 61, and a slider adapted to the slide rail may be provided on the fifth mounting frame 52, and the fifth mounting frame 52 may be stably moved relative to the mounting frame 61 by the cooperation of the slide rail and the slider. The slide rail and the slider are provided in two groups, which are respectively provided on the left and right sides of the above two, to further ensure the stable rise and fall of the fifth mounting frame 52.

[0243] Furthermore, a photoelectric switch can be arranged on the top of the mounting bracket 61, and a baffle can be arranged on the corresponding side of the fifth mounting bracket 52. When the fifth mounting bracket 52 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the fifth mounting bracket 52 has moved to the set height and reset. At this time, the power supply of the seventh driving element 51 can be disconnected to avoid overload and damage of the seventh driving element 51, and also save power consumption.

[0244] Furthermore, the multi-channel multi-detection POCT fully automatic chemiluminescence device 100 may also include components such as a control module, an electrical module, a display module, an image acquisition module, a heat dissipation module and an alarm module. The control module is electrically connected to the electrical module, the display module, the image acquisition module, the heat dissipation module and the alarm module, and the electrical module is also electrically connected to the display module, the image acquisition module, the heat dissipation module and the alarm module.

[0245] Exemplarily, the electrical module can be used to provide power support for the entire device, and the control module is used to control the operation of the device, such as controlling the opening and closing of each driving element, the opening and closing of the heating module, the display of the display module, and the image acquisition and image conversion of the image acquisition module. The display module can be used to display data such as the operating parameters of the device and project analysis results. The image acquisition module can be used to shoot and monitor the pre-processing work of the multi-channel multi-inspection parallel pre-processing device 40. When an abnormal operation is monitored, the control module can control the alarm module (such as sound and light alarm, display alarm, etc.) to issue a corresponding warning. The heat dissipation module is used to dissipate heat for the equipment to avoid overheating and affect normal operation.

[0246] The components such as the control module, the electrical module, the display module, the image acquisition module, the heat dissipation module and the alarm module are not related to the invention of the present invention, so they are not described in detail here, but only their connection relationship and basic functions are simply described. If there are any unclear points, those skilled in the art can refer to the structure, position and function of the components such as the control module, the electrical module, the display module, the image acquisition module, the heat dissipation module and the alarm module in the related art.

[0247] In the description of this specification, the description with reference to the terms "Example 1", "Example 2", etc. means that the specific features, structures, materials or characteristics described in conjunction with the implementation or example are included in at least one implementation or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same implementation or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more implementations or examples in a suitable manner.

[0248] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A multi-channel multi-test POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; A reaction chamber assembly provided on the mounting frame and used for loading a multiple test reagent strip, the reaction chamber assembly being reciprocatable along the length direction of the mounting frame, the multiple test reagent strip being used for detecting at least two markers, the multiple test reagent strip comprising a liquid sealing area, the liquid sealing area comprising a common liquid area and a dedicated liquid area distributed along the length direction of the multiple test reagent strip; A multi-channel multi-joint test parallel pre-processing device is arranged on the mounting frame, the multi-channel multi-joint test parallel pre-processing device comprises at least two rows of magnetic bars arranged side by side along the moving direction of the reaction chamber assembly, each row of the magnetic bars has at least two magnetic bars, and the at least two rows of the magnetic bars are used to transfer the magnetic particles in the adjacent holes of the multi-joint test reagent strip into the liquid sealing area; a membrane breaking component provided on the mounting frame and located at the rear end of the multi-channel multi-joint detection parallel pre-processing device, the membrane breaking component being used to break the sealing film of the common liquid area; and The PMT component is arranged on the mounting frame and located at the rear end of the membrane breaking component. The reaction chamber component is used to move the multiple test reagent strip to the PMT component. The PMT component is used to detect the luminescence value of the detection position of the multiple test reagent strip.

2. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The multi-channel multi-joint detection parallel pre-processing device comprises: A gantry is arranged on the bottom plate of the mounting frame, and a first driving element is arranged on the top of the gantry; a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the first driving element and being able to rise and fall under the drive of the first driving element to suck and discharge the sample on the multiple test reagent strip; and The sample pre-processing mechanism is arranged on the gantry, the sample pre-processing mechanism is connected to the first driving element in a transmission manner, and can be lifted and lowered under the drive of the first driving element, and at least two rows of magnetic bars are arranged on the sample pre-processing mechanism.

3. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 2, characterized in that: The sample pre-processing mechanism comprises: A first mounting frame provided on the gantry and drivingly connected to the first driving element, wherein the first driving element can drive the first mounting frame to rise and fall; a second driving element disposed on the first mounting frame; and A pre-processing component is arranged on the first mounting frame and is transmission-connected to the second driving element, at least two rows of magnetic bars are arranged on the pre-processing component and are transmission-connected to the second driving element, and the second driving element can drive at least two rows of magnetic bars to rise and fall to transfer magnetic particles.

4. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The pre-processing component comprises: A magnetic bar device is arranged on the first mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are arranged at the bottom of the magnetic bar device, and the plurality of first loading heads are connected to the plurality of movable through holes in a one-to-one correspondence; a first push plate disposed above the magnetic bar device, the first push plate being drivingly connected to the second driving element; and There are multiple connecting rods arranged on the first pushing plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The second driving element can drive the first pushing plate to drive the magnetic bars to rise and fall in the corresponding active through holes so as to be separated from the first loading head or pass through the first loading head.

5. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 4, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed along the width direction of the first push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly spaced and distributed along the length direction of the first pushing plate.

6. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The sample extraction mechanism comprises: A second mounting frame provided on the gantry and drivingly connected to the first driving element, wherein the first driving element can drive the second mounting frame to rise and fall; a third driving element disposed on the second mounting frame; and An extraction component is arranged on the second mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to rise and fall to suck and discharge samples.

7. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The extraction component comprises: An injection device arranged on the second mounting frame, wherein a plurality of injection cavities are formed in the injection device, a plurality of second loading heads for loading tip heads are arranged at the bottom of the injection device, and the plurality of second loading heads are connected to the plurality of injection cavities in a one-to-one correspondence; a second push plate disposed above the injection device, the second push plate being drivingly connected to the third driving element; and A plurality of piston rods are arranged on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The third driving element can drive the second push plate to drive the piston rods to rise and fall in the syringe cavity to perform a suction and exhalation action.

8. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The sample extraction mechanism also includes: A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the second push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and A separation plate is arranged at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

9. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The plurality of syringe cavities are evenly distributed along the length direction of the injection device, the plurality of second loading heads are evenly distributed along the length direction of the injection device, and the plurality of piston rods are evenly distributed along the length direction of the second push plate.

10. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism. The first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

11. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves; A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

12. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: A first slide seat is provided on a side of the first mounting frame facing the gantry, a first slide rail is provided on a side of the gantry facing the first mounting frame, the first slide rail extends along the height direction of the gantry, and the first slide seat is slidably connected to the first slide rail; A second slide seat is provided on a side of the second mounting frame facing the gantry, a second slide rail is provided on a side of the gantry facing the second mounting frame, the second slide rail extends along the height direction of the gantry, and the second slide seat is slidably connected to the second slide rail.

13. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: A first sensing element is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame. The first sensing element can generate or disconnect induction with the first detector as the first mounting frame rises and falls; A second sensing member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second sensing member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

14. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The reaction chamber assembly comprises: A guide rail provided on the bottom plate of the mounting frame; A reaction chamber body is arranged on the guide rail, a guide block is arranged at the bottom of the reaction chamber body and is slidably connected to the guide rail, and a plurality of evenly spaced receiving grooves are arranged on the reaction chamber body for loading the multi-test reagent strips, and the receiving grooves extend along the length direction of the reaction chamber body; A fourth driving element is arranged on the bottom plate of the mounting frame and located at the rear end of the guide rail, and a first driving pulley is arranged on the transmission shaft of the fourth driving element; a mounting seat disposed on the bottom plate of the mounting frame and located at the front end of the guide rail, the mounting seat being provided with a first driven pulley, the first driving pulley being transmission-connected to the first driven pulley via a belt; and A first synchronous belt pressure plate is arranged on one side of the reaction chamber body, and the first synchronous belt pressure plate is connected to a belt.

15. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The PMT assembly includes: A mounting bracket disposed on the bottom plate of the mounting frame; a third mounting bracket disposed on the mounting bracket; a fourth mounting frame disposed at the bottom of the third mounting frame; A PMT module disposed on the fourth mounting frame; A fifth driving element disposed on the top of the third mounting frame and drivingly connected to the fourth mounting frame, the fifth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down; A sixth driving element and a second driven pulley are respectively arranged on both sides of the top of the mounting bracket, a second driving pulley is arranged on the transmission shaft of the sixth driving element, and the second driving pulley is connected to the second driven pulley through a belt; and A second synchronous belt pressure plate is arranged on the third mounting frame, and the second synchronous belt pressure plate is connected to the belt.

16. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 15, characterized in that: The membrane breaking component comprises: a seventh driving element disposed on the top of the mounting bracket; a fifth mounting frame disposed on the mounting bracket and located below the seventh driving element, wherein the fifth mounting frame is drivingly connected to the seventh driving element and can be raised and lowered under the drive of the seventh driving element; and A plurality of membrane breaking heads are arranged at the bottom of the fifth mounting frame, and the plurality of membrane breaking heads are evenly distributed along the length direction of the fifth mounting frame.

17. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The multiple test reagent strip comprises: A reagent strip body, wherein the liquid sealing area is disposed on the reagent strip body; a handle disposed at one end of the test strip body; and A sample hole, a tip, at least two disposable magnetic separation sleeves, the dedicated liquid area and the common liquid area are arranged on the reagent strip body in sequence from the handle to the other end of the reagent strip body; The dedicated liquid area includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area includes a cleaning liquid and a luminescent substrate liquid.

Images