Pain sustained-release collateral-dredging ointment and preparation method thereof

Abstract

The invention discloses pain sustained-release collateral-dredging ointment and a preparation method, and relates to the field of traditional Chinese medicine plasters, the pain sustained-release collateral-dredging ointment comprises a cotton yarn layer, a heating layer, an adhesive layer, a film net bag layer and a cooling gel layer, the cooling gel layer is annularly pasted on the cotton yarn layer, the adhesive layer is arranged on the inner side of the cooling gel layer, the heating layer is arranged on the inner side of the adhesive layer, and the film net bag layer is arranged on the inner side of the heating layer. The heating layer is adhered to the cotton yarn layer, plaster is adhered to the side, away from the cotton yarn layer, of the heating layer, the plaster is covered with the thin film net bag layer, the thin film net bag layer is adhered to the cotton yarn layer, water and a heating agent are arranged on the heating layer, and the plaster is mainly composed of 6-9 parts of elderberry, 2-6 parts of coral snake, 2-5 parts of gaultheria yunnanensis and 2-5 parts of tetragonal wood veneer. The ointment prepared by combining the medicines has the functions of relieving swelling and pain and promoting blood circulation to remove meridian obstruction; meanwhile, the comfort of a patient can be improved after the plaster covers the skin, and the heating layer is arranged and used for improving the activity of molecules in the plaster and improving the treatment efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine plasters, in particular to a pain-releasing collateral-clearing plaster and a preparation method thereof. Background Art

[0002] Lumbar disc herniation is a disease characterized by low back and leg pain caused by the protrusion of the nucleus pulposus after the rupture of the annulus fibrosus and compression of the nerve roots. The lumbar disc is equivalent to a micro-motion joint, which is composed of a transparent cartilage plate, annulus fibrosus and nucleus pulposus, and is distributed between the lumbar vertebrae. When the annulus fibrosus ruptures due to degenerative changes or trauma of the lumbar disc, the nucleus pulposus protrudes from the ruptured area and compresses the lumbar nerves, resulting in radiating pain in the waist and legs.

[0003] Osteophyte is also known as hyperplastic osteoarthritis, osteoarthritis (OA), degenerative joint disease, senile arthritis, and hypertrophic arthritis. It is a disease caused by the degeneration and degradation of soft tissues such as cartilage, intervertebral discs, ligaments, etc. that constitute the joints, the formation of bone spurs on the edges of the joints, hypertrophy of the synovium, etc., resulting in bone destruction, secondary bone hyperplasia, and joint deformation. When subjected to abnormal loads, it causes symptoms such as joint pain and limited mobility.

[0004] Sciatica refers to radiating pain along the sciatic nerve, mainly in the buttocks, posterior thigh, posterior and lateral calf, and lateral dorsum of the foot.

[0005] The above lists several common symptoms of waist and leg pain, such as cervical spondylosis. Due to the nature of current work, the symptoms of cervical spondylosis and lumbar disc herniation are becoming younger and younger. For the above symptoms, Western medicine treatment is generally based on oral medication, while Chinese medicine treatment generally uses acupuncture, plasters and other means.

[0006] For the plaster for application, for example, the ointment mentioned by Zhang Bin in CN101721660A is composed of 10-15 parts of ginger, 3-5 parts of centipede, 4-6 parts of pangolin, 3-5 parts of silkworm, 3-5 parts of clematis, 3-5 parts of Cistanche, 4-7 parts of Rehmannia, 3-5 parts of Sinomenium, 4-6 parts of Salvia miltiorrhiza, 3-5 parts of toad venom, and 5-8 parts of Astragalus. Zhao Jilin mentioned in CN102670928A that it is composed of 5-10 parts of Sichuan pepper. The plaster composed of 5-10 parts of red pepper, 5-10 parts of white mustard seeds, 3-8 parts of dragon's blood, 3-10 parts of angelica dahurica, 4-8 parts of white bombyx batryticatus, 4-10 parts of lead powder, 3-8 parts of Panax notoginseng, 3-8 parts of Polygonum multiflorum, 4-10 parts of Rhodiola rosea, 4-8 parts of scorpion, 4-10 parts of Tripterygium wilfordii, 3-8 parts of safflower, 3-8 parts of vermilion and 2-4 parts of musk has good analgesic and therapeutic effects on cervical and lumbar vertebrae, with a cure rate of 85%.

[0007] Nevertheless, the efficacy of the Chinese medicine ointment can be further improved. Summary of the invention

[0008] Therefore, people are still in need of a Chinese medicine ointment with better pain-relieving and collateral-dredging effect for treating rheumatoid arthritis, lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, gout, osteoporosis, bone hyperplasia, sciatic nerve, and fracture injury. So far, no report on the pharmaceutical composition of the present invention has been found. The inventor has completed the present invention after repeated research and repeated verification by animal and clinical trials.

[0009] The purpose of the present invention is to provide a more effective pain-releasing and collateral-clearing ointment for treating rheumatoid arthritis, lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, gout, osteoporosis, bone hyperplasia, sciatic nerve and fracture injuries.

[0010] One object of the present invention is to provide a pain-releasing collateral-clearing ointment, comprising a cotton yarn layer, a heating layer, an adhesive layer, a film mesh bag layer and a cooling gel layer, wherein the cooling gel layer is annularly pasted on the cotton yarn layer, the adhesive layer is arranged on the inner side of the cooling gel layer, the heating layer is arranged on the inner side of the adhesive layer, the heating layer is bonded to the cotton yarn layer, a plaster is bonded to the side of the heating layer away from the cotton yarn layer, the outside of the plaster is covered with the film mesh bag layer, the film mesh bag layer is bonded to the cotton yarn layer, and the heating layer is separately provided with water and a heating agent.

[0011] The cooling gel layer uses the conventional cooling substance contained in the existing cooling patch; the heating agent uses calcium hydroxide particles, and the mass ratio of water to calcium hydroxide particles is 6:1, which ensures that a certain amount of heat is dissipated and avoids skin burns.

[0012] When the plaster is used, it adheres to the skin through the adhesive layer, and the outer cooling gel layer contacts the skin. The film mesh layer is a film mesh made of TPU elastomer, which is used to support the plaster and prevent the plaster from completely spreading and falling on the skin, so as to facilitate the subsequent tearing of the plaster. The thickness of the film mesh is 0.3mm.

[0013] Another object of the present invention is to provide a method for preparing the Chinese medicine ointment.

[0014] The plaster medicine of the present invention selects elderberry, dog tendon vine, osmanthus radiata, tetragonum bark and Bungarus bungeulatus for combination, and the medicine combination makes the efficacy of each medicine produce synergistic effect, so as to effectively treat rheumatoid arthritis, lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, gout, osteoporosis, bone hyperplasia, sciatica and bone fracture injury.

[0015] Among them, elderberry is selected because; Bungarus bungarus is selected because it is mild in nature, sweet and salty in taste, and can dispel wind and dredge meridians, dispel wind and dampness, especially can quickly relieve the symptoms of arthritis, joint swelling and pain, and meridian obstruction; elderberry is selected because it is sweet and bitter in taste and flat in nature, dispels wind, promotes dampness, promotes blood circulation, and relieves pain, and is used for rheumatic tendon and bone pain, low back pain, swelling and pain from falls, and fractures; Dog tendon vine is selected because it is sweet, light and warm in nature, can set bones and promote tissue regeneration, disperse blood stasis and relieve pain, dispel wind and dampness, and promote diuresis and reduce swelling, and can especially treat injuries from falls and rheumatic joint pain; Bone-penetrating incense is selected because it is pungent in taste, warm in nature, dispels wind and dampness, dispels cold and relieves pain, and promotes blood circulation and dredge meridians; Four-sided wood bark is selected because it is bitter and flat in nature, dispels wind and dampness, reduces swelling and relieves pain, and treats rheumatic bone pain and swelling and pain from falls.

[0016] In order to achieve better therapeutic effect, the medicine of the present invention is also combined with safflower, white mustard, clematis, sapodilla thorn and musk, wherein the clematis is selected because it is pungent, salty and warm in nature, can dispel wind and dampness, dredge meridians, is good at moving, has a wide action area and can lead the medicine quickly; the safflower is selected because it is pungent, sweet, warm and bitter, can promote blood circulation and menstruation, remove blood stasis and relieve pain; the white mustard is selected because it is warm in nature and pungent in taste, and is used to treat neuralgia, rheumatism, pleurisy and sprain; the sapodilla thorn is selected because it is warm in nature and pungent in taste, can reduce swelling and relieve pain, promote blood circulation and dispel wind; the musk is selected because it is pungent and warm in nature, can relieve pain and reduce swelling when applied externally; the above five medicines focus on promoting blood circulation, dredge meridians and dispel wind, and jointly assist the monarch and ministerial medicines to reduce swelling and relieve pain, promote blood circulation and dredge meridians.

[0017] In order to obtain the best therapeutic effect, the drug of the present invention can also be added with bitter herb and lithospermum officinale on the basis of the above drugs. The use of bitter herb and lithospermum officinale can help the disadvantages of the pungent properties of other drugs because bitter herb is cold and bitter, and lithospermum officinale is sweet, salty and cold, and thus can help the drugs penetrate into the tissues and reduce the body surface temperature. After being combined with the above drugs, the best therapeutic effect is achieved in treating rheumatoid arthritis, lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, gout, osteoporosis, bone hyperplasia, sciatic nerve, and fracture injuries.

[0018] The dosage of the drug components of the present invention is also obtained through a large number of studies by the inventors, and the dosage of each component has good efficacy within the following weight range: 6-9 parts of elderberry, 2-6 parts of dog tendon vine, 10-12 parts of Bungarus serpentina, 2-5 parts of Ampelopsis pilosula, and 2-5 parts of Tetrapanax cyrtonema.

[0019] Preferred are: 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus serrulata, 3.5 parts of Radix Angelicae Pubescentis, and 3.5 parts of Rhizoma Cibotii.

[0020] The dosage of each component of the medicine of the present invention can also be: 6-9 parts of elderberry, 2-6 parts of dog tendon vine, 10-12 parts of Bungarus cochinchinensis, 2-5 parts of Radix Angelicae Pubescentis, 2-5 parts of Rhizoma Cyperi, 2-3 parts of safflower, 3-6 parts of white mustard seeds, 2-4 parts of clematis, 2-4 parts of Gleditsia sinensis, and 0.5-1 part of musk.

[0021] Preferred are: 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus, 3.5 parts of Radix Pennisetum, 3.5 parts of Rhizoma Cyperi, 2.5 parts of safflower, 5 parts of white mustard seeds, 3 parts of clematis, 2.8 parts of Gleditsia sinensis, and 0.8 part of musk.

[0022] The dosage of the further components of the medicine of the present invention is: 6-9 parts of elderberry, 2-6 parts of dog tendon vine, 10-12 parts of Bungarus cochinchinensis, 2-5 parts of Radix Angelicae Pubescentis, 2-5 parts of Rhizoma Cibotii, 2-3 parts of safflower, 3-6 parts of white mustard seeds, 2-4 parts of clematis, 2-4 parts of Gleditsia sinensis, 0.5-1 part of musk, 3 parts of Herba Corydalis, and 2 parts of Lithospermum officinale.

[0023] The preferred ingredients are: 7.5 parts of Sambucus sambucus, 3 parts of Gnaphalium indica, 10 parts of Bungarus cochinchinensis, 3.5 parts of Radix Angelicae Pubescentis, 3.5 parts of Rhizoma Cibotii, 2.5 parts of Flos Carthami, 5 parts of Semen Sinapis, 3 parts of Radix Clematis, 2.8 parts of Spina Gleditsiae, 0.8 parts of Musk, 3 parts of Herba Cyperi, and 2 parts of Radix Lithospermi.

[0024] The drug of the present invention can be prepared into ointment or plaster by conventional methods of Chinese medicine ointment, but in order to make the raw materials of the drug exert their efficacy better, it is preferred to carry out special extraction of elderberry, dog tendon vine, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, and sapodilla thorn in the raw medicine, such as the aforementioned ethanol extraction, and crush the bitter herb and lithospermum officinale and use them directly. However, these cannot be used to limit the scope of protection of the present invention.

[0025] Preferably, the preparation method of the drug of the present invention is as follows: a) Weigh the raw materials of elderberry, dog tendon vine, Bungarus fasciatus, tetragonum multiflorum bark and osmanthus radiatus for later use; b) boiling the four herbs of elderberry, dog tendon vine, four-sided wood bark and radix schoenophorae in the weight ratio twice with water, adding water each time in an amount that covers the surface of the herbs, combining the two decoctions, filtering to obtain a filtrate 1, concentrating it into an extract with a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating it, and drying it at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight ratio and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and mixing the powder 1 and the powder 2 uniformly to prepare the active ingredient 1 of the medicine of the present invention; e) mixing the active ingredient 1 with water and honey, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

[0026] It is also combined with safflower, white mustard seeds, clematis, sapodilla thorns, and musk, and the preparation method is as follows: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, gleditsia sinensis, musk, and set aside; b) boiling the eight herbs of elderberry, dog tendon vine, radix polygoni multiflori, bark of four-sided wood, safflower, white mustard, clematis and gleditsia in the weight ratio twice with water, adding water in an amount that covers the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight ratio and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) mixing the active ingredient 1 with water and honey, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

[0027] Further adding kudiya ding jing and lithospermum officinale, the preparation method of the medicine of the present invention is: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, Gleditsia sinensis, musk, bitter herb, and lithospermum officinale, and set aside; b) boiling the eight herbs of elderberry, dog tendon vine, radix polygoni multiflori, bark of four-sided wood, safflower, white mustard, clematis and gleditsia in the weight ratio twice with water, adding water in an amount that covers the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight ratio and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) crushing Herba Corydalis and Radix Lithospermi to obtain a mixture 1; f) mixing the active ingredient 1 with water, honey and the mixed material 1, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

[0028] The ointment prepared from the drug combination of the present invention can be used to effectively treat rheumatoid arthritis, lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, gout, osteoporosis, bone hyperplasia, sciatic nerve, and fracture injuries, and has the functions of reducing swelling and relieving pain, and promoting blood circulation and unblocking meridians; at the same time, the various structures of the pain-releasing and unblocking meridian ointment provided are reasonably arranged, and a cooling gel layer is provided to reduce the skin temperature around the plaster and improve the patient's comfort. At the same time, a heating layer is provided between the plaster and the cotton yarn layer to increase the molecular activity inside the plaster and improve the treatment efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification, but do not constitute a limitation of the present invention. In the accompanying drawings: Figure 1 It is a schematic diagram of the structure of a pain-releasing collateral-clearing ointment of this embodiment.

[0030] In the figure, 1. cotton yarn layer; 2. heating layer; 3. adhesive layer; 4. film mesh bag layer; 5. cooling gel layer; 6. cake-shaped plaster. DETAILED DESCRIPTION

[0031] The present invention is further described in detail below in conjunction with the accompanying drawings.

[0032] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] In order to further understand the content, features and effects of the present invention, the following Experimental Example 1 and Experimental Example 2 are given as examples.

[0034] Test Example 1 Test materials: ①, the ointment provided by the present invention; ②, Lingyue Tongluo Qutong Ointment, national medicine standard Z20000065, from Henan Lingrui Pharmaceutical Co., Ltd.; ③, the ointment comparison group provided by the present invention.

[0035] Test material ① is prepared using the drug combination provided by the present invention, and the preparation method is as follows: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, gleditsia sinensis, musk, and set aside; b) boiling 8 herbs including elderberry, dog tendon vine, radix polygoni multiflori, bark of four square trees, safflower, white mustard, clematis and gleditsia in water twice, adding water to cover the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 55° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentis according to the weight ratio, drying the mixture at 55° C. for 100 h, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) mixing the active ingredient 1 with water and honey, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 cm; f) Place the cake-shaped ointment on the adhesive cotton cloth or gauze, and then cover it with cotton cloth or gauze of the same size, and the vacuum bagging is completed.

[0036] The raw material components include: 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus cochinchinensis, 3.5 parts of Radix Pennisetum, 3.5 parts of Rhizoma Cibotii, 2.5 parts of safflower, 5 parts of white mustard seeds, 3 parts of clematis, 2.8 parts of Gleditsia sinensis, 0.8 part of musk, 3 parts of Ceratonia suffruticosa, and 2 parts of Lithospermum officinale.

[0037] The test material ③ is prepared using the drug combination provided by the present invention, and the preparation method is as follows: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, Gleditsia sinensis, musk, bitter herb, and lithospermum officinale, and set aside; b) boiling 8 herbs including elderberry, dog tendon vine, radix polygoni multiflori, bark of four square trees, safflower, white mustard, clematis and gleditsia in water twice, adding water to cover the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 55° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentis according to the weight ratio, drying the mixture at 55° C. for 100 h, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) crushing Herba Corydalis and Radix Lithospermi to obtain a mixture 1; f) mixing the active ingredient 1 with water, honey and the mixture 1, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 cm; f) Place the cake-shaped ointment on the adhesive cotton cloth or gauze, and then cover it with cotton cloth or gauze of the same size, and the vacuum bagging is completed.

[0038] The raw material components include: 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus cochinchinensis, 3.5 parts of Radix Pennisetum, 3.5 parts of Rhizoma Cibotii, 2.5 parts of safflower, 5 parts of white mustard seeds, 3 parts of clematis, 2.8 parts of Gleditsia sinensis, 0.8 part of musk, 3 parts of Ceratonia suffruticosa, and 2 parts of Lithospermum officinale.

[0039] The difference between ① and ③ lies in whether bitter herbs and lithospermum officinale are added.

[0040] The test method is as follows: 60 mice were selected for experiment. After being treated with leg bone contusion and single leg fracture, the mice were divided into 4 groups, with 15 mice in each group. One group used test material ① as group 1, one group used test material ② as group 2, one group used test material ③ as group 3, and one group was the control group as group 4, without using any drug.

[0041] Cut the outer cotton cloth or gauze of test material ① into the same size as the inner cake-shaped ointment, roast it on an alcohol lamp for 1 minute, and apply it to the leg bone contusion and single leg fracture of mice; cut test material ② into 3 cm circles, and apply it to the leg bone contusion and single leg fracture of mice; cut the outer cotton cloth or gauze of test material ③ into the same size as the inner cake-shaped ointment, roast it on an alcohol lamp for 1 minute, and apply it to the leg bone contusion and single leg fracture of mice.

[0042] According to the above-mentioned patching method, the medicine was changed every two days, and the patching was cancelled after three consecutive changes. Before each dressing change, the redness and swelling status of the injured part of the mouse, the surface temperature of the injured part, and the movement status of the mouse were recorded.

[0043] The results showed that before the second dressing change, the activity of mice in group 4 was significantly lower than that of the other three groups, with obvious redness and swelling, and a higher body surface temperature. After the third dressing change, the results were recorded after the ointment was removed as shown in Table 1: Table 1: Results of the four groups of mice after removing the ointment The results show that the drug of the present invention has excellent therapeutic effect on dredging meridians and relieving pain, and after adding bitter herbs and lithospermum officinale, the body surface temperature is significantly reduced.

[0044] Test Example 2 A total of 60 outpatients were admitted, including 11 patients aged 20 to 30 years old, 12 patients aged 30 to 40 years old, 12 patients aged 40 to 50 years old, 15 patients aged 50 to 60 years old, and 10 patients aged 60 to 70 years old.

[0045] Diagnostic classification: The main symptoms were lumbar disc herniation and frozen shoulder in 26 patients, the main symptoms were bone hyperplasia and sciatica in 15 patients, the main symptoms were gout and fracture injury in 8 patients, and the main symptoms were osteoporosis and rheumatoid arthritis in 11 patients.

[0046] Treatment method: Apply the ointment of the present invention to the target affected area. The ointment used is drug ③ in Test Example 1. Change it once a day and apply it 5 times a week. One week is one course of treatment. There are two courses of treatment. Additional drugs for patients with fracture injuries are anti-inflammatory drugs.

[0047] The treatment results are shown in Table 2: Table 2: Patients' status after the second course of treatment In summary, after two courses of treatment, 60 cases were treated with the ointment of the present invention, and the results showed that 36 cases were effective, 21 cases were improved, 4 cases were ineffective, and the total effective rate reached 93%.

[0048] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0049] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0050] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A pain-releasing plaster, characterized in that: It includes a cotton yarn layer, a heating layer, an adhesive layer, a film mesh bag layer and a cooling gel layer. The cooling gel layer is annularly pasted on the cotton yarn layer, the adhesive layer is arranged on the inner side of the cooling gel layer, the heating layer is arranged on the inner side of the adhesive layer, the heating layer is bonded to the cotton yarn layer, a plaster is bonded on the side of the heating layer away from the cotton yarn layer, the outside of the plaster is covered with the film mesh bag layer, the film mesh bag layer is bonded to the cotton yarn layer, and the heating layer is separately provided with water and a heating agent.

2. The pain-releasing plaster according to claim 1, characterized in that: The plaster is mainly prepared from the following raw materials in parts by weight: 6-9 parts of elderberry, 2-6 parts of dog tendon vine, 10-12 parts of Bungarus multiflorus, 2-5 parts of Rhizoma Cibotii, and 2-5 parts of Rhizoma Cibotii bark.

3. A method for preparing a pain-releasing Tongluo plaster, using the pain-releasing Tongluo plaster of claims 1-2, comprising the following steps: a) Weigh the raw materials of elderberry, dog tendon vine, Bungarus fasciatus, tetragonum multiflorum bark and osmanthus radiata for later use; b) boiling the four herbs of elderberry, dog tendon vine, four-sided wood bark and radix schoenophorae in the weight ratio twice with water, adding water each time in an amount that covers the surface of the herbs, combining the two decoctions, filtering to obtain a filtrate 1, concentrating it into an extract with a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating it, and drying it at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight proportion and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and mixing the powder 1 and the powder 2 uniformly to prepare the active ingredient 1 of the medicine of the present invention; e) mixing the active ingredient 1 with water and honey, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

4. The method for preparing the drug according to claim 3, wherein the weight ratio of the active ingredient 1 to water and honey is 3-5:1.5:0.

5.

5. The medicine according to claim 2, wherein the raw materials also include: 2-3 parts of safflower, 3-6 parts of white mustard seeds, 2-4 parts of clematis, 2-4 parts of gleditsia thorns, and 0.5-1 part of musk.

6. The medicine according to claim 5, wherein the ingredients are 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus cochinchinensis, 3.5 parts of Radix Angelicae Pubescentis, 3.5 parts of Rhizoma Cyperi, 2.5 parts of safflower, 5 parts of white mustard seeds, 3 parts of clematis, 2.8 parts of Gleditsia sinensis, and 0.8 part of musk.

7. A method for preparing the drug according to claim 5, comprising the following steps: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, gleditsia sinensis, musk, and set aside; b) boiling the eight herbs of elderberry, dog tendon vine, radix polygoni multiflori, bark of four-sided wood, safflower, white mustard, clematis and gleditsia in the weight ratio twice with water, adding water in an amount that covers the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight proportion and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) mixing the active ingredient 1 with water and honey, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

8. The medicine according to claim 5, wherein the raw material medicine further comprises: 2-4 parts of bitter herbs and 1-3 parts of lithospermum officinale.

9. The medicine according to claim 8, wherein the dosage of each component is: 7.5 parts of elderberry, 3 parts of dog tendon vine, 10 parts of Bungarus cochinchinensis, 3.5 parts of Radix Angelicae Pubescentis, 3.5 parts of Rhizoma Cyperi, 2.5 parts of safflower, 5 parts of white mustard seeds, 3 parts of clematis, 2.8 parts of Gleditsia sinensis, 0.8 part of musk, 3 parts of Herba Cyperi, and 2 parts of Lithospermum officinale.

10. A method for preparing the drug according to claim 8 or 9, comprising the following steps: a) Weigh each raw material medicine, elderberry, dog tendon vine, Bungarus, radix scutellariae, tetragonum bark, safflower, white mustard, clematis, Gleditsia sinensis, musk, bitter herb, and lithospermum officinale, and set aside; b) boiling the eight herbs of elderberry, dog tendon vine, radix polygoni multiflori, bark of four-sided wood, safflower, white mustard, clematis and gleditsia in the weight ratio twice with water, adding water in an amount that covers the surface of the herbs each time, combining the two decoctions, filtering to obtain a filtrate 1, concentrating to an extract having a specific gravity of 1.35, adding 90% to 95% ethanol for alcohol precipitation to recover the ethanol and concentrating, and drying at 50 to 60° C. to obtain a dry extract 1; c) removing the internal organs of the Bungarus serpentina in the weight proportion and drying the mixture, drying the mixture at 50 to 60° C. for 90 to 120 hours, and drying and grinding the mixture into powder 1; d) grinding the dry extract 1 into powder 2, and uniformly mixing the powder 1, musk powder and powder 2 to prepare the active ingredient 1 of the medicine of the present invention; e) crushing Herba Corydalis and Radix Lithospermi to obtain a mixture 1; f) mixing the active ingredient 1 with water, honey and the mixed material 1, and mixing them evenly to form a cake-shaped ointment 1, wherein the diameter of the cake-shaped ointment is 3 to 10 cm; f) Place the cake-shaped ointment on the adhesive heating layer, and then cover it with a film mesh bag layer of the same size. Adhesive layers and cooling gel layers are sequentially bonded to the periphery of the cake-shaped ointment, and vacuum bagging is completed.

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