The utility model provides a pharmaceutical three-dimensional motion mixing device, which comprises a case, a
mixing tank, a driving mechanism and a
rocker arm mechanism, the two ends of the
mixing tank are respectively provided with a feed end and a
discharge end, the feed end is detachably provided with an end cover, the end cover is provided with a mounting column and a feed
pipe, the mounting column is rotatably provided with a mounting frame, and the feed
pipe is provided with a feed port. A fixing mechanism for fixing the mounting frame is arranged on the mounting column, a plurality of
grating plates are detachably arranged on the mounting frame, a clamping mechanism for fixing the
grating plates is arranged on the mounting frame, a turning cover is rotationally arranged on the side wall of the
mixing tank, a
fastener for fixing the turning cover is arranged, and a driving mechanism is matched with a
rocker arm mechanism to drive the mixing tank to do three-dimensional motion relative to the case. And the plurality of
grating plates on the mounting frame can collide with the materials in the mixing process to crush the blocky materials, so that the material mixing quality is improved, and the turnover cover can be opened, the fixing mechanism and the clamping mechanism can be unlocked and the mounting frame can be rotated according to requirements, so that the grating plates can be sequentially disassembled to be cleaned and replaced.