Bactericide composition and preparation method thereof

Abstract

The invention discloses a bactericide composition and a preparation method thereof. The bactericide composition is prepared from the following raw materials in parts by weight: 30-40 parts of tetramycin, 50-60 parts of copper (succinate + glutarate + adipate), 30-40 parts of benziothiazolinone, 30-40 parts of dimethomorph, 25-30 parts of a modified titanium dioxide nano material, 200-240 parts of a solvent, 5-8 parts of an emulsifier, 5-8 parts of a dispersant, 5-8 parts of a wetting agent and 2-5 parts of a preservative. The titanium dioxide nano material is modified, the electronic structure of titanium dioxide is changed, the photocatalytic activity of the titanium dioxide nano material under visible light is improved, and the titanium dioxide nano material is used for exciting the antibacterial activity of active components including tetramycin, copper (succinate + glutarate + adipate), benziothiazolinone and dimethomorph, so that the bactericide composition can quickly achieve the bactericidal effect; meanwhile, the modified titanium dioxide nano material can also destroy bacterial cell membranes, so that the sterilization effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of fungicides, in particular to a fungicide composition and a preparation method thereof. Background Art

[0002] In the growth of crops, fungicides are an indispensable means of preventing and controlling diseases. As the country strengthens its management of environmental protection issues in agricultural production, the use of high-efficiency, low-toxic, high-activity, and low-residue fungicides has become an inevitable trend.

[0003] A fungicide is a pesticide formulation used to control plant diseases. It usually contains two or more active ingredients with fungicidal effects. Fungicides are an important part of the agricultural plant protection field. They improve the control effect, delay the development of resistance, and reduce the cost of use by combining fungicides with different mechanisms of action.

[0004] However, the existing fungicide compositions have poor antibacterial activity and cannot quickly achieve a bactericidal effect, leading to a series of problems such as the pathogens being easily resistant to drugs. Therefore, there is an urgent need for a product to increase the efficacy and delay the risk of drug resistance of pathogens, thereby minimizing economic losses and improving planting benefits. Summary of the invention

[0005] The object of the present invention is to provide a fungicide composition and a preparation method thereof to solve the problems raised in the above background technology.

[0006] According to a first aspect of the present invention, there is provided a fungicide composition, comprising the following raw materials in parts by weight:

[0007] 30-40 parts of tetramycin, 50-60 parts of copper succinate, 30-40 parts of thiophanate-methyl, 30-40 parts of oxadiazine, 25-30 parts of modified titanium dioxide nanomaterials, 200-240 parts of solvents, 5-8 parts of emulsifiers, 5-8 parts of dispersants, 5-8 parts of wetting agents, and 2-5 parts of preservatives.

[0008] According to an embodiment of the present invention, the modification method of the modified titanium dioxide nanomaterial is: coupling the titanium dioxide nanomaterial and zinc oxide through a hydrothermal method, and then calcining to obtain the modified titanium dioxide nanomaterial.

[0009] According to an embodiment of the present invention, the modified titanium dioxide nanomaterial introduces metal ion zinc to change the electronic structure of titanium dioxide and improve the photocatalytic activity of titanium dioxide under visible light.

[0010] According to an embodiment of the present invention, the solvent is one or two of propanol, isopropanol and propylene glycol.

[0011] According to an embodiment of the present invention, the emulsifier is a cationic surfactant.

[0012] According to an embodiment of the present invention, the dispersant is one of naphthalenesulfonate and polycarboxylate.

[0013] According to an embodiment of the present invention, the wetting agent is a mixture of alkyl sulfate and alkyl naphthalene sulfonate, and the mixing mass ratio of the alkyl sulfate and the alkyl naphthalene sulfonate is 1:1.

[0014] According to an embodiment of the present invention, the preservative is a mixture of formaldehyde and sodium benzoate, and the mixing mass ratio of the formaldehyde and sodium benzoate is 2:1.

[0015] According to a second aspect of the present invention, there is provided a method for preparing the above-mentioned fungicide composition, comprising the following steps:

[0016] Step 1, weigh tetramycin, copper succinate, thiophanate-methyl, oxadiazine, modified titanium dioxide nanomaterials, solvents, emulsifiers, dispersants, wetting agents, and preservatives respectively by weight;

[0017] Step 2, mixing tetramycin, copper succinate, thiophanate-methyl and oxadiazine to obtain an initial mixture;

[0018] Step 3: Add the solvent, emulsifier, dispersant, wetting agent and preservative to the initial mixture in sequence and stir evenly, then add the modified titanium dioxide nanomaterial, and continue stirring until the modified titanium dioxide nanomaterial is evenly mixed into the other components to obtain the fungicide composition.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] The invention inhibits various plant pathogenic bacteria and fungi by tetramycin, destroys the cell structure of pathogenic bacteria by copper succinate releasing copper ions, and improves the sterilization effect by combining tetramycin and copper succinate; destroys the nuclear structure of pathogenic bacteria and interferes with the metabolism of pathogenic bacteria cells by thiamethoxam, and destroys the cell wall membrane of pathogenic bacteria by dimethomorph; tetramycin, copper succinate, thiamethoxam and dimethomorph are combined into active components, which have broad antibacterial activity and can effectively inhibit various plant pathogenic bacteria and fungi;

[0021] By modifying the titanium dioxide nanomaterial, changing the electronic structure of titanium dioxide, and improving the photocatalytic activity of the titanium dioxide nanomaterial under visible light, the antibacterial activity of the active components of tetramycin, copper succinate, thiophanate-methyl and oxadiazine is stimulated, so that the fungicide composition can quickly exert a bactericidal effect and prevent the bacteria from developing drug resistance. At the same time, the modified titanium dioxide nanomaterial itself can also destroy the bacterial cell membrane and increase the bactericidal effect. DETAILED DESCRIPTION

[0022] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0023] A fungicide composition, composed of the following raw materials in parts by weight:

[0024] 30-40 parts of tetramycin, 50-60 parts of copper succinate, 30-40 parts of thiophanate-methyl, 30-40 parts of oxadiazine, 25-30 parts of modified titanium dioxide nanomaterials, 200-240 parts of solvents, 5-8 parts of emulsifiers, 5-8 parts of dispersants, 5-8 parts of wetting agents, and 2-5 parts of preservatives.

[0025] Among them, tetramycin is used to inhibit a variety of plant pathogenic bacteria and fungi, copper succinate releases copper ions to destroy the cell structure of pathogens, and the combination of tetramycin and copper succinate can improve the bactericidal effect; thiophanate-methyl can destroy the nuclear structure of pathogenic cells and interfere with the metabolism of pathogenic cells, and oxadimethoxine can destroy the cell wall membrane of pathogens; tetramycin, copper succinate, thiophanate-methyl and oxadimethoxine are combined into active components, which have broad antibacterial activity and can effectively inhibit a variety of plant pathogenic bacteria and fungi.

[0026] According to an embodiment of the present invention, the modification method of the modified titanium dioxide nanomaterial is as follows: the titanium dioxide nanomaterial and zinc oxide are coupled by a hydrothermal method, and then calcined to obtain the modified titanium dioxide nanomaterial; the modified titanium dioxide nanomaterial introduces metal ion zinc to change the electronic structure of titanium dioxide and improve the photocatalytic activity of titanium dioxide under visible light; by modifying the titanium dioxide nanomaterial, the electronic structure of titanium dioxide is changed, and the photocatalytic activity of the titanium dioxide nanomaterial under visible light is improved, which is used to stimulate the antibacterial activity of the active components of tetramycin, copper succinate, thiophanate-methyl and oxadiazine, so that the bactericidal composition can quickly exert a bactericidal effect and avoid the development of drug resistance in pathogens. At the same time, the modified titanium dioxide nanomaterial itself can also destroy the bacterial cell membrane and increase the bactericidal effect.

[0027] According to an embodiment of the present invention, the solvent is one or two of propanol, isopropanol and propylene glycol, and the solvent can dissolve the active ingredient and make it uniformly dispersed in the preparation.

[0028] According to an embodiment of the present invention, the emulsifier is a cationic surfactant, and the emulsifier helps the oil-water two-phase mixture to form a stable emulsion.

[0029] According to an embodiment of the present invention, the dispersant is one of naphthalenesulfonate and polycarboxylate, and the dispersant is used to improve the dispersibility of the active ingredient in the dilution medium.

[0030] According to an embodiment of the present invention, the wetting agent is a mixture of alkyl sulfate and alkyl naphthalene sulfonate, the mixing mass ratio of alkyl sulfate and alkyl naphthalene sulfonate is 1:1, and the wetting agent is used to reduce the surface tension of the liquid and promote the spreading of the liquid on the solid surface.

[0031] According to an embodiment of the present invention, the preservative is a mixture of formaldehyde and sodium benzoate, the mixing mass ratio of formaldehyde and sodium benzoate is 2:1, and the preservative is used to extend the shelf life of the preparation and prevent microbial contamination.

[0032] According to a second aspect of the present invention, there is provided a method for preparing the above-mentioned fungicide composition, comprising the following steps:

[0033] Step 1, weigh tetramycin, copper succinate, thiophanate-methyl, oxadiazine, modified titanium dioxide nanomaterials, solvents, emulsifiers, dispersants, wetting agents, and preservatives respectively by weight;

[0034] Step 2, mixing tetramycin, copper succinate, thiophanate-methyl and oxadiazine to obtain an initial mixture;

[0035] Step 3: Add the solvent, emulsifier, dispersant, wetting agent and preservative to the initial mixture in sequence and stir evenly, then add the modified titanium dioxide nanomaterial, and continue stirring until the modified titanium dioxide nanomaterial is evenly mixed into the other components to obtain the fungicide composition.

[0036] The above preparation method was used to prepare the fungicide compositions of the following examples, and the specific examples are shown below.

[0037] Example 1

[0038] A fungicide composition, composed of the following raw materials in parts by weight:

[0039] 30 parts of tetramycin, 50 parts of copper succinate, 30 parts of thiophanate-methyl, 30 parts of oxadiazine, 25 parts of modified titanium dioxide nanomaterials, 230 parts of propanol, 6 parts of cationic surfactants, 6 parts of naphthalene sulfonates, 3 parts of alkyl sulfates, 3 parts of alkyl naphthalene sulfonates, 2 parts of formaldehyde, and 1 part of sodium benzoate.

[0040] Example 2

[0041] A fungicide composition, composed of the following raw materials in parts by weight:

[0042] 30 parts of tetramycin, 50 parts of copper succinate, 30 parts of thiophanate-methyl, 30 parts of oxadiazine, 30 parts of modified titanium dioxide nanomaterials, 230 parts of propanol, 6 parts of cationic surfactants, 6 parts of naphthalene sulfonates, 3 parts of alkyl sulfates, 3 parts of alkyl naphthalene sulfonates, 2 parts of formaldehyde, and 1 part of sodium benzoate.

[0043] Example 3

[0044] A fungicide composition, composed of the following raw materials in parts by weight:

[0045] 40 parts of tetramycin, 60 parts of copper succinate, 40 parts of thiophanate-methyl, 40 parts of oxadiazine, 30 parts of modified titanium dioxide nanomaterials, 230 parts of propanol, 6 parts of cationic surfactants, 6 parts of naphthalene sulfonates, 3 parts of alkyl sulfates, 3 parts of alkyl naphthalene sulfonates, 2 parts of formaldehyde, and 1 part of sodium benzoate.

[0046] Comparative Example 1

[0047] A fungicide composition, composed of the following raw materials in parts by weight:

[0048] 30 parts of tetramycin, 50 parts of copper succinate, 30 parts of thiophanate-methyl, 30 parts of oxadiazine, 25 parts of titanium dioxide nanomaterials, 230 parts of propanol, 6 parts of cationic surfactants, 6 parts of naphthalene sulfonates, 3 parts of alkyl sulfates, 3 parts of alkyl naphthalene sulfonates, 2 parts of formaldehyde, and 1 part of sodium benzoate.

[0049] The difference between this comparative example and Example 1 is that the modified titanium dioxide nanomaterial is replaced with ordinary titanium dioxide nanomaterial, and the other combinations are the same as those in Example 1.

[0050] Comparative Example 2

[0051] A fungicide composition, composed of the following raw materials in parts by weight:

[0052] 30 parts of tetramycin, 50 parts of copper succinate, 30 parts of thiophanate-methyl, 30 parts of oxadiazine, 230 parts of propanol, 6 parts of cationic surfactant, 6 parts of naphthalene sulfonate, 3 parts of alkyl sulfate, 3 parts of alkyl naphthalene sulfonate, 2 parts of formaldehyde and 1 part of sodium benzoate.

[0053] The difference between this comparative example and Example 1 is that the modified titanium dioxide nanomaterial is omitted, and other combinations are the same as those in Example 1.

[0054] Experimental example

[0055] This experimental example is to test the control effect of rice sheath blight, damping-off and bacterial leaf streak. Before the test, the antibacterial composition prepared in Examples 1-3 and Comparative Examples 1-2 needs to be diluted twice, and the dilution ratio is the mass ratio of the antibacterial composition to clean water is 1:100;

[0056] Experimental location: In the rice experimental area of ​​Wuxi, Jiangsu, plots with similar growth and fertility were selected. Other subsequent water and fertilizer management and mechanized management were the same;

[0057] The specific steps of the test are:

[0058] (1) Six experimental fields (each with an area of ​​1 mu) were selected in the experimental area. The six experimental fields were not adjacent and were marked as: experimental field 1, experimental field 2, experimental field 3, control field 1, control field 2 and blank control field. The dilutions of the fungicide compositions of Examples 1-3 were sprayed on the leaves of the experimental fields 1-3; the dilutions of the fungicide compositions of Control Groups 1-2 were sprayed on the leaves of the control fields 1-2; and the same weight of clean water was sprayed on the leaves of the blank control field;

[0059] The application rate of the fungicide composition dilution was 10 kg / mu (the same amount of clean water was applied in the blank control field).

[0060] 20 days after spraying the diluted fungicide composition, the conditions of rice sheath blight, damping-off and bacterial leaf streak in the test field were investigated and counted in accordance with GB / T17980 Pesticide Field Efficacy Test Guidelines;

[0061] The disease index was calculated according to formula (1), and the control effect was calculated according to formula (2). The results are shown in Table 1:

[0062]

[0063] Table 1

[0064]

[0065] It can be seen from the above table that the bactericidal effect of the bactericide composition prepared in Examples 1-3 is significantly better than that of the bactericide composition prepared in Comparative Examples 1-2. By comparing and analyzing the data of Example 1, Comparative Example 1 and Comparative Example 2, it can be seen that when the modified titanium dioxide nanomaterial is used, the bactericidal effect of the bactericide composition is optimal. Therefore, the present application modifies the titanium dioxide nanomaterial, changes the electronic structure of titanium dioxide, and improves the photocatalytic activity of the titanium dioxide nanomaterial under visible light, which is used to stimulate the antibacterial activity of tetramycin, copper succinate, thiophanate-methyl and oxadiazine active components, so that the bactericide composition can quickly exert a bactericidal effect and avoid the development of drug resistance in pathogens. At the same time, the modified titanium dioxide nanomaterial itself can also destroy the bacterial cell membrane, increase the bactericidal effect, and can effectively prevent and control rice sheath blight, damping-off and bacterial streak disease.

[0066] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A fungicide composition, characterized in that: It is composed of the following raw materials in parts by weight: 30-40 parts of tetramycin, 50-60 parts of copper succinate, 30-40 parts of thiophanate-methyl, 30-40 parts of oxadiazine, 25-30 parts of modified titanium dioxide nanomaterials, 200-240 parts of solvents, 5-8 parts of emulsifiers, 5-8 parts of dispersants, 5-8 parts of wetting agents, and 2-5 parts of preservatives.

2. A fungicide composition according to claim 1, characterized in that: The modification method of the modified titanium dioxide nano material is: coupling the titanium dioxide nano material and zinc oxide through a hydrothermal method, and then calcining to obtain the modified titanium dioxide nano material.

3. A fungicide composition according to claim 2, characterized in that: The modified titanium dioxide nanomaterial introduces metal ion zinc to change the electronic structure of titanium dioxide and improve the photocatalytic activity of titanium dioxide under visible light.

4. A fungicide composition according to claim 1, characterized in that: The solvent is one or two of propanol, isopropanol and propylene glycol.

5. A fungicide composition according to claim 1, characterized in that: The emulsifier is a cationic surfactant.

6. A fungicide composition according to claim 1, characterized in that: The dispersant is one of naphthalenesulfonate and polycarboxylate.

7. A fungicide composition according to claim 1, characterized in that: The wetting agent is a mixture of alkyl sulfate and alkyl naphthalene sulfonate, and the mixing mass ratio of the alkyl sulfate and the alkyl naphthalene sulfonate is 1:

1.

8. A fungicide composition according to claim 1, characterized in that: The preservative is a mixture of formaldehyde and sodium benzoate, and the mixing mass ratio of the formaldehyde to sodium benzoate is 2:

1.

9. A method for preparing a fungicide composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: Step 1, weigh tetramycin, copper succinate, thiophanate-methyl, oxadiazine, modified titanium dioxide nanomaterials, solvents, emulsifiers, dispersants, wetting agents, and preservatives respectively by weight; Step 2, mixing tetramycin, copper succinate, thiophanate-methyl and oxadiazine to obtain an initial mixture; Step 3: Add the solvent, emulsifier, dispersant, wetting agent and preservative to the initial mixture in sequence and stir evenly, then add the modified titanium dioxide nanomaterial, and continue stirring until the modified titanium dioxide nanomaterial is evenly mixed into the other components to obtain the fungicide composition.

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