Self-adaptive inspiration flow trigger type asthma quantitative inhaler

Abstract

The invention discloses a self-adaptive inspiration flow trigger type asthma quantitative inhaler which comprises an actuating shell, a gallipot storage shell is arranged in the actuating shell, a gallipot is arranged in the gallipot storage shell, and a pressing mechanism is arranged in the actuating shell and located above the gallipot storage shell. A limiting block is arranged outside the gallipot storage shell, a stud is arranged on the outer side of the actuating shell, a triggering mechanism is arranged on the stud, a stopping mechanism is arranged on the outer side of the actuating shell and located below the triggering mechanism, and a flow meter is arranged on the outer side of the actuating shell and located below the stopping mechanism. The self-adaptive inspiration flow triggering type quantitative inhaler has the beneficial effects that the self-adaptive inspiration flow triggering type quantitative inhaler can ensure that a patient can inhale medicine at the optimal time under the current inspiration condition under different inspiration conditions of the patient, the oral-laryngeal deposition rate of the medicine is reduced, and the administration efficiency is improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, in particular to an adaptive inhalation flow-triggered asthma metered-dose inhaler. Background Art

[0002] According to a survey conducted by the Chinese Lung Health Research Organization, there are about 45.7 million asthma patients over the age of 20 in my country, and more than 6 million underage patients. Asthma is not only common in the elderly, but also accounts for a high proportion in children. China has become one of the countries with the highest asthma mortality rates in the world, and the prevalence of asthma is still increasing year by year, which has brought serious burdens to social and economic development. Metered-dose inhalers are the main equipment for the treatment of asthma. The correct use of metered-dose inhalers requires patients to coordinate inhalation and compression. However, most metered-dose inhaler devices on the market are manually actuated, which makes it difficult for patients to coordinate inhalation and compression when using metered-dose inhalers, resulting in a high oral and throat deposition rate of metered-dose inhaler drug particles and low lung administration efficiency, which not only reduces the treatment effect, but also the drugs deposited in the mouth and throat may cause throat irritation, coughing, hoarseness, and oropharyngeal candidal infection.

[0003] At the same time, studies have shown that under different inhalation conditions, the optimal actuation flow of the metered-dose inhaler (the patient's inhalation flow when the metered-dose inhaler is actuated) is different. Inhaling drugs at the wrong time will also lead to higher oral deposition of drug particles and lower lung drug delivery efficiency.

[0004] The structure of metered-dose inhalers on the market consists of two parts: a plastic fixing seat (including the inhalation port) and a metered-dose valve. When the user manually lifts and presses the valve, the drug and propellant are sprayed out in the form of an aerosol. In order to achieve the best therapeutic effect, the inhaler needs to be driven at the optimal point of the patient's inhalation cycle. However, this metered-dose inhaler requires manual actuation by the patient, and due to the inherent limitations of the patient and poor training, the patient has difficulty in inhaling and pressing coordination, resulting in a high oral and throat deposition rate of the metered-dose inhaler and low pulmonary drug delivery efficiency. At the same time, studies have shown that under different inhalation conditions, the optimal actuation flow of the metered-dose inhaler (the patient's inhalation flow when the inhaler is actuated) varies, and blindly pursuing the triggering of the metered-dose inhaler at the moment of inhalation is not the best method.

[0005] Therefore, it is necessary to design an adaptive inhalation flow-triggered metered-dose inhaler and a working method to help users inhale drugs at the best time to improve the drug delivery efficiency of the metered-dose inhaler. Summary of the invention

[0006] The purpose of the present invention is to solve the above problems and to design an adaptive inhalation flow-triggered asthma metered-dose inhaler.

[0007] To achieve the above-mentioned purpose, the technical solution of the present invention is an adaptive inhalation flow-triggered asthma metered-dose inhaler, comprising an actuating shell, a medicine canister storage shell is arranged in the actuating shell, a medicine canister is arranged in the medicine canister storage shell, a pressing mechanism is arranged in the actuating shell above the medicine canister storage shell, a limiting block is arranged outside the medicine canister storage shell, a stud is arranged outside the actuating shell, a trigger mechanism is arranged on the stud, a stop mechanism is arranged outside the actuating shell below the trigger mechanism, and a flow meter is arranged outside the actuating shell below the stop mechanism.

[0008] As a further description of the present technical solution, the pressing mechanism includes a pressing cover arranged in the actuating shell and located above the medicine tank storage shell, a limiting rod is arranged on the side of the pressing cover, a spring mounting tube is arranged on the bottom end surface of the pressing cover, and a cylindrical spring is arranged in the spring mounting tube.

[0009] As a further description of the technical solution, the trigger mechanism includes an electromagnet arranged outside the actuating housing.

[0010] As a further description of the technical solution, a spring guide groove is provided on the actuating housing, and a limiting rod is arranged in the spring guide groove.

[0011] As a further description of the technical solution, a limiting hole is provided on the actuating housing, and a second connecting rod limiting block is arranged in the limiting hole.

[0012] As a further description of the technical solution, the stop mechanism includes a second stop link arranged on the outside of the actuating housing and below the trigger mechanism, the second stop link is provided with a second link limit block, the second stop link is provided with a rotatable first stop link, and the first stop link is connected to the trigger mechanism at one end away from the second stop link.

[0013] As a further description of the technical solution, the flow meter includes a venturi tube, a first pressure port and a second pressure port are arranged on a side of the venturi tube, and a gas flow channel is connected to the venturi tube.

[0014] A method for operating an adaptive inhalation flow-triggered asthma metered-dose inhaler comprises the following steps:

[0015] Step S1, collecting inspiratory airflow;

[0016] Step S2, adjusting the actuation flow of the device according to the initial inspiratory flow rate growth rate of the patient;

[0017] Step S3, waiting for the patient's inspiratory flow to reach the actuating flow;

[0018] Step S4: When the patient's inspiratory flow rate reaches the actuating flow rate, the device releases the drug.

[0019] As a further description of the present technical solution, in step S2, the device can adaptively adjust the optimal actuation flow rate according to the initial breathing state of the patient, and the device will release the drug only when the patient's inhalation reaches the changed flow rate. The specific method includes: when the inhalation flow rate growth rate is between 0-1.5L / min / s, the patient is at a resting breathing intensity, the peak inhalation flow rate is about 15L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is between 1.5L / min / s-3L / min / s, it is inhalation under moderate exercise intensity, the peak inhalation flow rate is about 30L / min, and the actuation flow rate is set to 0L / min, that is, immediate actuation; when the inhalation flow rate growth rate is between 3-4.5L / min / s, it is inhalation under higher exercise intensity, the peak inhalation flow rate is about 60L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is greater than 4.5L / min / s, it is inhalation under intense exercise intensity, the peak inhalation flow rate is greater than 60L / min, and the actuation flow rate is set to 0L / min.

[0020] The beneficial effect lies in that the adaptive inhalation flow triggered metered-dose inhaler of the present invention will judge the patient's current respiratory state according to the patient's initial inhalation flow rate growth rate, and then adjust the device's actuation flow. When the patient's inhalation flow reaches the actuation flow, the device automatically releases the medicine. The adaptive adjustment of the actuation flow can ensure that the patient can inhale the medicine at the best time in the current state regardless of the breathing state in which he inhales. The inhaler of the present technical solution can improve the problem of inhalation and compression coordination difficulties to improve its drug administration efficiency. The adaptive inhalation flow triggered metered-dose inhaler of the present invention can ensure that the patient can inhale the medicine at the best time under the current inhalation conditions under different inhalation conditions of the patient, thereby reducing the oral and throat deposition rate of the medicine and improving the drug administration efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural schematic diagram of the self-adaptive inhalation flow rate triggered metered dose inhaler of the present invention;

[0022] Figure 2 is a cross-sectional view of the adaptive inhalation flow rate triggered metered dose inhaler of the present invention;

[0023] Figure 3 is a structural schematic diagram of a pressing cover in a pressing mechanism;

[0024] Figure 4 It is a schematic diagram of the connecting rod structure in the stop mechanism;

[0025] Figure 5 It is a control principle block diagram of an adaptive inspiratory flow-triggered metered-dose inhaler;

[0026] Figure 6 It is a test result diagram of the actuation flow rate and lung deposition rate of the metered-dose inhaler under different inhalation conditions;

[0027] Figure 7 It is a schematic diagram of the working method of the adaptive inspiratory flow-triggered metered-dose inhaler.

[0028] In the figure, 1. pressing mechanism; 11. pressing cover; 111. limiting rod; 112. spring mounting tube; 12. cylindrical spring; 2. actuating shell; 21. spring guide groove; 22. stud; 23. limiting hole; 3. trigger mechanism; 31. electromagnet; 4. stop mechanism; 41. first stop link; 42. second stop link; 421. second link limit block; 5. flow meter; 51. venturi tube; 52. first pressure port; 53. second pressure port; 54. gas flow channel; 6. medicine tank storage shell; 61. limiting block; 7. medicine tank. DETAILED DESCRIPTION

[0029] First of all, the original intention of the design of the present invention is explained. The metered-dose inhaler is the main equipment for treating asthma. The correct use of the metered-dose inhaler requires the patient to coordinate the inhalation and compression. However, most of the metered-dose inhaler devices on the market are manually actuated, which makes it difficult for the patient to coordinate the inhalation and compression when using the metered-dose inhaler, resulting in a high oral and throat deposition rate of the metered-dose inhaler drug particles and a low pulmonary drug delivery efficiency, which not only reduces the treatment effect, but also the drugs deposited in the mouth and throat may cause throat irritation, coughing, hoarseness, and oropharyngeal candidal infection. Therefore, the present invention designs an adaptive inhalation flow-triggered asthma metered-dose inhaler.

[0030] The present invention will be described in detail below in conjunction with the accompanying drawings. Figure 1-Figure 7 As shown, an adaptive inhalation flow-triggered asthma metered-dose inhaler comprises an actuating shell 2, wherein a medicine tank 7 storage shell 6 is arranged in the actuating shell 2, a medicine tank 7 is arranged in the medicine tank 7 storage shell 6, a pressing mechanism 1 is arranged in the actuating shell 2 above the medicine tank 7 storage shell 6, and the pressing mechanism 1 will be described in detail below. The pressing mechanism 1 comprises a pressing cover 11 arranged in the actuating shell 2 above the medicine tank 7 storage shell 6, a limiting rod 111 is arranged on the side of the pressing cover 11, a spring mounting tube 112 is arranged on the bottom end surface of the pressing cover 11, a cylindrical spring 12 is arranged in the spring mounting tube 112, when the patient presses the pressing cover 11, the limiting rod 111 is stuck in the spring guide groove 21 to prevent the spring 12 from resetting upward, so that the spring 12 can store energy to drive the metered-dose inhaler.

[0031] A limit block 61 is arranged outside the medicine tank 7 storage housing 6, a trigger mechanism 3 is arranged outside the actuating housing 2, a stud 22 is arranged outside the actuating housing 2, and a trigger mechanism 3 is arranged on the stud 22. The trigger mechanism 3 will be described in detail below, and the trigger mechanism 3 includes an electromagnet 31 arranged outside the actuating housing 2.

[0032] A stop mechanism 4 is disposed outside the actuating housing 2 and below the trigger mechanism 3. The stop mechanism 4 will be described in detail below. Figure 4 As shown, the stop mechanism 4 includes a second stop link 42 arranged on the outside of the actuating housing 2 and below the trigger mechanism 3, and a second link limit block 61421 is arranged on the second stop link 42, and a rotatable first stop link 41 is arranged on the second stop link 42, and the first stop link 41 is connected to the trigger mechanism 3 at one end away from the second stop link 42, and the second link is used to prevent the second link from being separated from the limit hole 23 under the action of the electromagnet 31.

[0033] A flow meter 5 is disposed on the outer side of the actuating housing 2 below the stop mechanism 4 . The flow meter 5 includes a venturi tube 51 . A first pressure port 52 and a second pressure port 53 are disposed on the side of the venturi tube 51 . A gas flow channel 54 is connected to the venturi tube 51 .

[0034] A spring guide groove 21 is provided on the actuating housing 2 , a limiting rod 111 is arranged in the spring guide groove 21 , a limiting hole 23 is provided on the actuating housing 2 , a second connecting rod limiting block 421 is arranged in the limiting hole 23 .

[0035] Before use, the patient needs to press the pressing cover in advance and rotate the pressing cover clockwise. Figure 3 ) is stuck in the spring guide groove 21, preventing the cylindrical spring 12 from returning to its original position. At the same time, the stop mechanism 4 stops against the limit block 61, thereby preventing the medicine can 7 from moving downward under the action of the spring and releasing the medicine. When the actuation condition is reached ( Figure 6 ), the control module drives the electromagnet 31, the electromagnet 31 is energized and attracted, driving the first connecting rod to move upward, thereby driving the second connecting rod to move, and the second connecting rod moves horizontally in the direction away from the limiting block 61 under the action of the second connecting rod limiting hole 23. At this time, the limiting block 61 loses its stop, and the medicine tank 7 moves downward under the action of the pressing mechanism 1 to release the medicine.

[0036] like Figure 2As shown in the cross-sectional view, the electromagnet 31 is fixed to the actuator housing 2 by the stud 22. The flow meter 5, the gas flow channel 54 and the actuator housing 2 are designed in an integrated manner, so that the flow meter 5 can accurately monitor the patient's inspiratory flow. The flow meter 5 is based on the Venturi effect, that is, when the restricted flow passes through the reduced flow cross section, the flow velocity of the fluid increases, and its flow velocity is inversely proportional to the flow cross section. According to the Bernoulli equation, the greater the flow velocity, the smaller the pressure. Therefore, when there is inspiratory flow, a pressure difference is generated between the first pressure port 52 and the second pressure port 53. The pressure difference causes a change in the output voltage of the differential pressure sensor, and the flow through the Venturi tube 51 can be inversely calculated through the voltage change.

[0037] The following is a detailed description of the working method of the adaptive inspiratory flow triggered metered dose inhaler, including the following steps:

[0038] Step S1, collecting inspiratory airflow;

[0039] Step S2, adjusting the actuation flow of the device according to the initial inspiratory flow rate growth rate of the patient;

[0040] Step S3, waiting for the patient's inspiratory flow to reach the actuating flow;

[0041] Step S4: When the patient's inspiratory flow rate reaches the actuating flow rate, the device releases the drug.

[0042] In step S2, the device can adaptively adjust the optimal actuation flow rate according to the initial breathing state of the patient, and the device will release the drug only when the patient's inhalation reaches the changed flow rate. The specific method includes: when the inhalation flow rate growth rate is between 0-1.5L / min / s, the patient's breathing intensity is at rest, the peak inhalation flow rate is about 15L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is between 1.5L / min / s-3L / min / s, it is the inhalation under moderate exercise intensity, the peak inhalation flow rate is about 30L / min, and the actuation flow rate is set to 0L / min, i.e., immediate actuation; when the inhalation flow rate growth rate is between 3-4.5L / min / s, it is the inhalation under high exercise intensity, the peak inhalation flow rate is about 60L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is greater than 4.5L / min / s, it is the inhalation under intense exercise intensity, the peak inhalation flow rate is greater than 60L / min, and the actuation flow rate is set to 0L / min. Figure 6 As shown, the coordination of the above-mentioned inhalation and device drug delivery timing can effectively improve the efficiency of pulmonary drug delivery.

[0043] Figure 5The control principle block diagram of the device is shown in FIG. 1 , wherein the control module is electrically connected to the electromagnet 3131 and the flow meter 55, and can collect and process the data received by the flow meter 55 to control the attraction of the electromagnet 3131. The control module may be, for example but not limited to, a STM32 series processor.

[0044] The adaptive inhalation flow-triggered metered-dose inhaler of the present invention will judge the patient's current respiratory state according to the patient's initial inhalation flow rate growth rate, and then adjust the device's actuation flow. When the patient's inhalation flow reaches the actuation flow, the device automatically releases the drug. The adaptive adjustment of the actuation flow can ensure that the patient can inhale the drug at the best time in the current state regardless of the respiratory state in which he inhales. The inhaler of this technical solution can improve the problem of difficulty in coordinating inhalation and compression, so as to improve its drug administration efficiency.

[0045] The above technical solutions only reflect the preferred technical solutions of the technical solutions of the present invention. Some changes that may be made to certain parts thereof by technicians in this technical field all reflect the principles of the present invention and fall within the protection scope of the present invention.

Claims

1. An adaptive inspiratory flow-triggered asthma metered dose inhaler, characterized in that: The invention comprises an actuating shell (2), wherein a medicine tank storage shell (6) is arranged inside the actuating shell (2), a medicine tank (7) is arranged inside the medicine tank storage shell (6), a pressing mechanism (1) is arranged inside the actuating shell (2) and located above the medicine tank storage shell (6), a limiting block (61) is arranged outside the medicine tank storage shell (6), a stud (22) is arranged outside the actuating shell (2), a trigger mechanism (3) is arranged on the stud (22), a stop mechanism (4) is arranged outside the actuating shell (2) and located below the trigger mechanism (3), and a flow meter (5) is arranged outside the actuating shell (2) and located below the stop mechanism (4).

2. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The pressing mechanism (1) comprises a pressing cover (11) arranged in an actuating housing (2) and located above a medicine bottle storage housing (6); a limiting rod (111) is arranged on the side of the pressing cover (11); a spring mounting tube (112) is arranged on the bottom end surface of the pressing cover (11); and a cylindrical spring (12) is arranged in the spring mounting tube (112).

3. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The trigger mechanism (3) comprises an electromagnet (31) arranged outside the actuating housing (2).

4. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The actuating housing (2) is provided with a spring guide groove (21), and a limiting rod (111) is arranged in the spring guide groove (21).

5. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The actuating housing (2) is provided with a limiting hole (23), and a second connecting rod limiting block (421) is arranged in the limiting hole (23).

6. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The stop mechanism (4) comprises a second stop link (42) arranged outside the actuating housing (2) and below the trigger mechanism (3); a second link limit block (421) is arranged on the second stop link (42); a rotatable first stop link (41) is arranged on the second stop link (42); and an end of the first stop link (41) away from the second stop link (42) is connected to the trigger mechanism (3).

7. The adaptive inspiratory flow-triggered asthma metered dose inhaler according to claim 1, characterized in that: The flow meter (5) comprises a venturi tube (51), a first pressure port (52) and a second pressure port (53) are arranged on the side of the venturi tube (51), and a gas flow channel (54) is connected to the venturi tube (51).

8. A method for operating an adaptive inspiratory flow-triggered asthma metered-dose inhaler as claimed in any one of claims 1 to 7, characterized in that: The following steps are involved: Step S1, collecting inspiratory airflow; Step S2, adjusting the actuation flow of the device according to the initial inspiratory flow rate growth rate of the patient; Step S3, waiting for the patient's inspiratory flow to reach the actuating flow; Step S4: When the patient's inspiratory flow rate reaches the actuating flow rate, the device releases the drug.

9. The method for operating the adaptive inspiratory flow-triggered asthma metered-dose inhaler according to claim 8, characterized in that: In the step S2, the device can adaptively adjust the optimal actuation flow rate according to the initial breathing state of the patient, and the device will release the drug only when the patient's inhalation reaches the changed flow rate. The specific method includes: when the inhalation flow rate growth rate is between 0-1.5L / min / s, the patient is at a resting breathing intensity, the peak inhalation flow rate is about 15L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is between 1.5L / min / s-3L / min / s, it is inhalation under moderate exercise intensity, the peak inhalation flow rate is about 30L / min, and the actuation flow rate is set to 0L / min, that is, immediate actuation; when the inhalation flow rate growth rate is between 3-4.5L / min / s, it is inhalation under high exercise intensity, the peak inhalation flow rate is about 60L / min, and the actuation flow rate is set to 5L / min; when the inhalation flow rate growth rate is greater than 4.5L / min / s, it is inhalation under intense exercise intensity, the peak inhalation flow rate is greater than 60L / min, and the actuation flow rate is set to 0L / min.

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