Facial mask for medical or cosmetic purposes with micellar extract

Abstract

The present invention relates to a (facial) mask for medical or cosmetic purposes, containing a micellar extract or a micellar lipophilic active ingredient, in particular a (facial) mask comprising one or more solubilizers of a lipophilic active ingredient, the lipophilic active ingredient is selected from the group consisting of plant extracts, plant extracts, plant parts, plant therapeutic agents, resins, vitamins, enzymes, proteins, algae, functional actives and / or coenzymes, and mixtures and combinations thereof.

Description

Technical Field

[0001] The present invention relates to a (facial) mask for medical or cosmetic purposes, containing micellar extracts or micellized lipophilic active ingredients. Background Art

[0002] DE 10002350 A1 discloses a facial mask for covering a facial area, which is intended to support the application of ointments or creams on the face by increasing the temperature. In order to enable the facial mask to absorb a heating agent or a cooling agent, it consists of a first lower film and a second upper film, which are arranged one above the other and welded to each other along their periphery to form a cavity. In order to improve the wearing comfort, in particular when the facial mask is laid for a long time, the facial mask has cutouts for the mouth, nose and eyes. In addition, the facial mask also has one or two straps for fixing to the head of the mask wearer to prevent the facial mask from slipping when the wearer lies down or sits down. Finally, in order to stabilize the shape of the facial mask, a weld is provided between the two films forming a cavity for accommodating the cooling agent or the heating agent.

[0003] DE 19930838 A1 discloses a facial mask for medical and cosmetic purposes, the basic shape of which is adapted to the human face. The mask can be spread on the face outside the mask area for cosmetic treatment or care treatment or for protecting the skin during treatment. The facial mask comprises a central eye, nose, mouth and cheek part and a forehead part and a jaw part for covering the facial area. In addition, it also has notches for the eyes, mouth and nose. The mask is fixed to the wearer's face with a laterally arranged retaining device in the form of temples or rings for connection to the ears.

[0004] EP 0063875 A2 relates to a cosmetic mask for performing a cosmetic facial wrap containing liquid ingredients.

[0005] EP 2489286 A2 discloses an applyable cosmetic facial mask. Summary of the invention

[0006] The object of the present invention is to provide a ready-to-use facial mask for cosmetic or medical purposes, in which the active ingredients for the care or healing treatment of the skin are prepared in such a way that they are well absorbed by the skin and thereby lead to an improved skin impression.

[0007] In the case of the facial mask according to the invention, this object is achieved by:

[0008] The mask contains a solubilizer of a lipophilic active ingredient

[0009] The mask is made of flexible materials

[0010] If it covers the entire face, it contains cutouts for through holes such as the eyes and nose

[0011] In order to enable visual perception and unhindered breathing during treatment, if the mask covers the entire face, it has cutouts for eye and nose passages. This increases the comfort of the user and allows an individual adjustment to their needs. But it is also possible that the mask covers only part of the face or neck. It is also possible that it extends as far as the décolletage or covers other body parts.

[0012] The mask consists of a flexible material. This can be a cellulose-containing material, a cotton-containing material or a silk-containing material, as well as any combinations and mixtures thereof. Preferred is biocellulose, most preferably a material consisting of 90-98% water and 2-10% cellulose. In a preferred embodiment, a mask consisting of 96% water and 4% cellulose is used. Here, the term "biocellulose" is understood to mean a smooth, rough or grainy flat textile material for the preparation of a facial mask. The facial mask can consist of cellulose or a cellulose nonwoven in the form of one or more layers. In a preferred embodiment, the biocellulose mask is prepared by fermenting bacteria. It is 100% compostable and adheres well to the skin due to its properties. Further preferred features of the biocellulose mask are:

[0013] -Fiber diameter is 2-100nm

[0014] -Fiber length is 1-9mm

[0015] -Three-dimensional structure

[0016] However, alternatively, other flexible materials are also considered, such as film materials or materials consisting of cotton fibers or silk fibers. The thickness of the layer(s) is flexible and depends on the liquid absorbency of the facial mask required for the respective application scenario.

[0017] The style of the mask can vary. The mask can cover the entire face, a portion of the face, the neck, the lower chest or other body parts. The terms "mask" and "facial mask" are used interchangeably and the term "facial" is not to be construed restrictively as only the face. It acts as a carrier for active substances that can enter the skin.

[0018] Preferably, the mask according to the invention is sterile and individually packaged. In a preferred embodiment, the mask, in particular a biocellulose mask, is located on a moistened cloth consisting of a nonwoven fabric and is covered with a perforated white plastic film, so that the mask can be folded in the package and prevented from drying out. The package is preferably a film consisting of aluminum, which can be printed, for example by means of CMYK printing.

[0019] The facial mask preferably has eye holes, nose holes and optionally mouth holes. In the cheek parts, there may be optional channels for accommodating the ears of the mask wearer. The face is divided into a forehead part and a jaw part as well as a central eye part, a nose part, a mouth part and a cheek part. These parts are assigned to the corresponding areas of the facial mask. On the side next to the central face part of the facial mask, optional channels for accommodating the ears can be provided, which surround the ears and firmly fix the facial mask. Therefore, the facial mask can not accidentally slide off the face during handling.

[0020] In a preferred embodiment of the invention, at least one notch is also provided for the nose, which is formed by a trapezoidal opening, which can have a cutout or notch in the face mask up to the level of the eye portion in the direction of the axis of symmetry of the face area, so as to be able to adapt to different nose shapes. In order to make the nose opening work, the mask portion surrounded by the through hole is laid on the nose and thus forms a channel for the nose.

[0021] The mask is loaded with a solubilized active ingredient. The solubilizer is a water-soluble micelle that surrounds a lipophilic substance. The purpose of preparing the solubilizer is to surround lipophilic or insoluble or poorly water-soluble substances so that they are water-soluble. The combination of (one or more) emulsifiers, fat-soluble active ingredients and adjuvants forms a stable, transparent and water-soluble solubilizer. As emulsifiers, polysorbate, Lutrol, gum arabic, sucrose stearate, Dermofeel G 10LW (70) MB, paste G 10L, PEG-40 hydrogenated castor oil, lecithin, hydrogenated phosphatidylcholine (Phospholipon) or D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS; other names: Vitamin E TPGS, tocosolone (INN)). For example, TPGS is an amphiphilic emulsifier, which has a hydrophilic and a lipophilic molecular part. The polyethylene glycol part is the polar head and the tocopheryl succinate is the lipophilic tail. This amphiphilic property leads to the self-association of TPGS in water (micelle formation). As a result, the fat-soluble components are surrounded in the interior of the micelle (lipophilic part) and dissolved in water through the water-soluble surface of the micelle. Possible auxiliary agents for improving the solubility of substances that are poorly soluble in water are, for example, ethanol (96%), polysorbate, glycerol (water-free). For further details on the preparation of the solubilisates, reference is made to the contents of the applicant's European applications EP 3675825 (EP 18738297) and EP 3675824 (EP 18737274).

[0022] The active ingredient, which is stably enclosed in the micelles, is protected from the effects of heat, light and / or chemical instability (eg oxidation).

[0023] Since the mask consists mainly of water, it can be loaded with micelles. The mask releases its moisture to the skin and thus also releases the active ingredients. Studies have shown that the mask absorbs at least 20%, preferably at least 50%, of the solubiliser used in the preparation.

[0024] As active ingredients, lipophilic plant extracts, plant extracts, phytotherapeutics, algae, resins, vitamins, enzymes, proteins, functional active substances and / or coenzymes, as well as mixtures and combinations thereof come into consideration. All of the active ingredients mentioned have their positive effect on the skin, which includes both cosmetic applications for the care and cleansing of any skin type, in particular for achieving an anti-aging effect, and therapeutic applications in the case of skin diseases such as acne, erysipelas, urticaria, herpes, neurodermatitis, burns or psoriasis.

[0025] Examples of possible plant extracts or plant extracts or phytotherapeutic agents are evening primrose (Oenotherabiennis), cardiospermum halicacabum, pansy (Viola tricolor), horsetail (Equisetum arvense), German chamomile (Matricaria recutita), witch hazel (Hamamelisvirginiana), Mahonia aquifolium, birch (Betulapendula), ylang-ylang, Siberian ginseng (Acanthopanax), shea butter (Avocado oil), flax plant (Cannabinoide), turmeric (Curcuma langa), lavender (Lavandula angustifolia), Hypericum walnut (Hypericumperforatum), Chondrus Crispus, hops (Humulus Lupulus), green tea (Camellia sinensis L.), Centella asiatica, Malva sylvestris), mosquito grass (Filipendula ulmaria), marigold (Calendula officinalis L.) or red clover (Trifolium pratense).

[0026] Examples of possible algae are brown algae, red algae, green algae or blue algae.

[0027] Examples of possible vitamins are vitamin E, vitamin A, provitamin A (beta-carotene), vitamin C, vitamin B3 (niacin), panthenol provitamin B5 and vitamin B7 (biotin).

[0028] Examples of enzymes, proteins and coenzymes are lipase, cellulase, amylase, protease, collagen, acetyl hexapeptide-8, pentapeptide-18 or coenzyme-10 (Q10).

[0029] Examples of possible resins are frankincense, propolis or myrrh.

[0030] Examples of further functionally active substances are fruit acids (e.g. glycolic acid, lactic acid, malic acid, citric acid, tartaric acid), resveratrol, pterostilbene, astaxanthin, or substances which are able to interact with the hypoxia inducible factor (HIF), mTor, p53, GDNF, GLUT1 functional pathways.

[0031] Particularly preferred solubilisers are:

[0032] Micronized Q10 or Astaxanthin -> Applications: Anti-wrinkle, Energy enhancer, Antioxidant

[0033] Micronized frankincense -> Application: antibacterial, anti-inflammatory

[0034] Micronized propolis->Application: antibacterial, anti-inflammatory

[0035] Micronized Siberian ginseng, resveratrol, pterostilbene or HIF inhibitors -> Applications: anti-aging, anti-wrinkle, anti-bacterial, anti-inflammatory

[0036] One or more further (water-soluble) substances having a positive effect on the skin can be added to the solubiliser or applied directly to the mask, such as hyaluronic acid, aloe vera, Centella asiatica extract, green tea extract, lactic acid, urea (carbamide) or amino acids.

[0037] Furthermore, cosmetic or pharmaceutical auxiliaries, such as preservatives, thickeners or binders, may also be present.

[0038] As shown in the examples, the solubilizer and the serum surrounding it in the mask remain stable over a long period of time, ie, do not show degradation.

[0039] Furthermore, masks loaded with the above-mentioned solubilized active ingredients were subjected to dermatological tests. All masks are suitable for normal and sensitive skin. This means that the micelles are particularly gentle on the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In the following Figure 1 and 2 The present invention is described in more detail.

[0041] Figure 1 A facial mask according to the invention consisting of biocellulose laid on a fabric consisting of a nonwoven fabric is shown.

[0042] (1) Nonwoven fabric layer

[0043] (2) Biocellulose mask.

[0044] Figure 2 A facial mask according to the invention is shown showing the existing through holes for the eyes, nose and mouth.

[0045] (3) Plastic film with holes Example

[0046] The invention is illustrated by the following examples.

[0047] Example 1: Loading of facial mask

[0048] The cut mask is placed in an airtight package and loaded with the essence containing the solubilized coenzyme in a filling device. Here, the device dispenses a certain amount of 15-45 g of essence into the finished package. By pressing the side of the package several times, the essence is evenly distributed, so that the mask is completely wetted with the essence. The package is then welded. After 3-7 days of storage, the mask is saturated with the essence.

[0049] Preparation of Essence:

[0050]

[0051] Other features of biocellulose mask:

[0052] -Fiber diameter is 2-100nm

[0053] -Fiber length is 1-9mm

[0054] -Three-dimensional structure

[0055] Example 2: Measuring the stability of the solubilized substance in the facial mask

[0056] The solubilized substances of different active ingredients were extracted from the corresponding facial masks and their stability was measured.

[0057] In order to study the stability of the solubilized substances, the ingredients in the masks and essences were determined and measured at room temperature and 40°C over a period of three months. Q10 solubilized substances, Siberian ginseng solubilized substances, propolis solubilized substances and frankincense solubilized substances were analyzed here. During the development of the analytical method, it was found that at least 50% of the concentration of the raw materials used was rediscovered in the masks. This can be explained by diffusion. Before the biocellulose mask (i.e. a prefabricated mask with up to 98% water by total weight) was placed in the essence, an equilibrium of the substance mass concentration occurred. In this case, the mask absorbed at least 50% of the active ingredient. The determined initial value of the substance mass concentration is the starting value of the zero point measurement and represents 100% of the starting value.

[0058] Q10-Biocellulose Mask Post-treatment

[0059] The mask immersed in 3% essence solution was cut into pieces of about 1 g and filled with about 4 g of tetrahydrofuran (THF) in a small tube and immersed for at least 4 hours. During the extraction time, the sample material was vortexed in the small tube. The total weight of the mask sample and the total weight of the solvent were added and recorded.

[0060] 100 μl of the solution in which the sample was present was taken out and mixed with 900 μl of methanol / 1-propanol (50 / 50 v / v).The sample was then measured on HPLC-UV.

[0061] With the help of a 6-point calibration curve between 1-100 μg / ml, the content in the extracted solution can be determined. Quality control samples that must have predetermined values ​​(3 μg / ml, 50 μg / ml, 80 μg / ml) serve as controls during the run. After measuring the extract, about 50% of the used raw material is rediscovered. The essence is measured together. The determined and verified value is taken as the initial value.

[0062] Siberian Ginseng-Biocellulose Mask Post-treatment

[0063] The mask soaked in 3% essence solution was cut into pieces of about 1 g and filled with about 4 g of water (H2O) in a small tube and soaked for at least 4 hours. During the extraction time, the sample material was vortexed in the small tube. The total weight of the mask sample and the total weight of the solvent were added and recorded.

[0064] Take out 200 μl of the solution in which the sample is present and mix with 800 μl of methanol / water (50 / 50 v / v). The sample is then measured on HPLC-UV. As a reference standard, ferulic acid is used as described in Ph.Eur9.0 / 1419. The content of eleutheroside B can therefore be calculated. For comparison, the Siberian ginseng solubilizer used is diluted to 3%, similar to the mask essence, to determine the eleutheroside B content. Starting from the determined values ​​in the diluted solubilizer, the deviations in the essence and the mask can be determined. 57% of the active ingredients used were rediscovered. This value is taken as the initial value.

[0065] Frankincense-Biocellulose Mask Post-treatment

[0066] The mask immersed in 3% essence solution was cut into pieces of about 1 g and filled with about 4 g of tetrahydrofuran (THF) in a small tube and immersed for at least 4 hours. During the extraction time, the sample material was vortexed in the small tube. The total weight of the mask sample and the total weight of the solvent were added and recorded.

[0067] 1000 μl of the solution in which the sample was present were taken out and first centrifuged and subsequently measured on the HPLC-UV.

[0068] With the aid of a 4-point calibration curve between 10 and 200 μg / ml of the used boswellic acid (AKBA) as reference standard, the content in the extracted solution can be determined. The essence and the used solubilizer are measured together. After measuring the extract, about 50% of the used starting material is recovered. The determined and verified value is taken as the initial value.

[0069] Propolis-Biocellulose Mask Post-treatment

[0070] The mask immersed in 3% essence solution was cut into pieces of about 1 g and filled with about 4 g of water / acetonitrile (90 / 10 v / v) in a small tube and immersed for at least 4 hours. During the extraction time, the sample material was vortexed in the small tube. The total weight of the mask sample and the total weight of the solvent were added and recorded.

[0071] 1000 μl of the solution in which the sample was present were taken out and first centrifuged and subsequently measured on the HPLC-UV.

[0072] With the aid of a 4-point calibration curve between 2 and 20 μg / ml of the chrysin used as a reference standard, the content in the extracted solution can be determined. The essence and the solubilizer used are measured together. After measuring the extract, about 66% of the used starting material is found again. The determined and verified value is taken as the initial value.

[0073] The measured data of the solubilized substance in the mask are shown below:

[0074] Biocellulose facial mask

[0075] Propolis Solubilizer

[0076]

[0077]

[0078] Biocellulose facial mask

[0079]

[0080] Biocellulose facial mask

[0081] Siberian ginseng solubilizer

[0082]

[0083] Biocellulose facial mask

[0084] Frankincense solubilizer

[0085]

[0086] The measured data show that the concentration of the raw materials used must be taken into account, because material balance occurs due to diffusion. The solubilizer in the mask remains stable, and the liquid (essence) surrounding the mask also remains stable with the solubilizer. The stability of the solubilizer in the mask is guaranteed for at least 12 months starting from storage at 40°C.

Claims

1. (Facial) mask comprising one or more solubilizers of lipophilic active ingredients selected from plant extracts, plant extracts, plant parts, phytothenic agents, resins, vitamins, enzymes, proteins, algae, functional active substances and / or coenzymes, and mixtures and combinations thereof.

2. The facial mask according to claim 1, wherein the plant extract, plant extract or botanical therapeutic agent is derived from evening primrose (Oenothera biennis), cardiospermum halicacabum, pansy (Violatricolor), horsetail (Equisetum arvense), German chamomile (Matricaria recutita), witch hazel (Hamamelis virginiana), Mahonia aquifolium, birch (Betula pendula), ylang-ylang, Siberian ginseng (Acanthopanax senticosus), shea butter (Avocado oil), sesame plant (Cannabinoide), turmeric (Curcuma langa), Lavandula angustifolia, Hypericumperforatum, Chondrus Crispus, hops (Humulus Lupulus), green tea (Camellia sinensis L.), Centella asiatica (Centella asiatica), mallow (Malva sylvestris), mosquito grass (Filipendula ulmaria), marigold (Calendula officinalis L.), red clover (Trifolium pratense).

3. The facial mask according to claim 1, wherein the vitamin is vitamin E, vitamin A, provitamin A (β-carotene), vitamin C, vitamin B3 (niacin) and / or vitamin B7 (biotin).

4. The facial mask according to claim 1, wherein the enzyme, protein or coenzyme is lipase, cellulase, amylase, protease, collagen, acetyl hexapeptide-8, pentapeptide-18 and / or coenzyme-10 (Q10).

5. The facial mask according to claim 1, wherein the resin is frankincense, propolis or myrrh.

6. The facial mask according to claim 1, wherein the functional active substance is astaxanthin, resveratrol, pterostilbene, fruit acid or a substance that can interact with hypoxia inducible factor (HIF), mTor, p53, GDNF, GLUT1 functional pathways.

7. The facial mask according to any one of claims 1-6, wherein the solubilizer is a combination of (one or more) emulsifiers, fat-soluble active ingredients and adjuvants.

8. The facial mask according to claim 7, wherein the emulsifier is selected from polysorbate, Lutrol and / or D-α-tocopheryl polyethylene glycol 1000 succinate.

9. The facial mask according to claim 7 or 8, wherein the auxiliary agent is ethanol, polysorbate and / or glycerol.

10. The facial mask according to any one of claims 1 to 9, wherein it is made of biocellulose.

11. Use of a facial mask according to any one of claims 1 to 10 for cosmetic purposes of caring for and cleansing any skin type.

12. Use according to claim 11, wherein an anti-aging effect on the skin is achieved.

13. Use of a facial mask according to any one of claims 1 to 10 for therapeutic applications in cases of dermatological diseases.

14. Use of the facial mask according to claim 14, wherein the skin disease is acne, herpes, neurodermatitis, urticaria, erysipelas, burns or psoriasis.

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