Personalized 3D printed skull restoration with porous composite hydroxyapatite coating

Abstract

The invention relates to the technical field of skull repair, and discloses a personalized 3D printing porous composite hydroxyapatite coating skull repair body which comprises a truss structure, a plurality of porous areas are distributed on the truss structure, bionic bone trabecula structures are integrally formed in the porous areas, the truss structure is composed of hollow pipes communicating with one another, and the hollow pipes communicate with one another. A plurality of small holes and micro holes which are communicated with the interior of the hollow pipe are formed in the hollow pipe, and a composite coating of a hydroxyapatite coating and titanium is sprayed on the porous area; the invention provides a personalized 3D printed skull restoration with a porous composite hydroxyapatite coating. The problem that the biocompatibility, the bone induction capability and the bone ingrowth effect of an existing skull restoration need to be improved is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of skull repair, and in particular to a personalized 3D printed porous composite hydroxyapatite coating skull repair body. Background Art

[0002] After skull injury or disease, skull repair is an important means to restore the patient's normal physiological function. Traditional skull prostheses have problems such as low strength, insufficient aesthetics, weak bone induction ability, and poor bone formation ability. With the development of 3D printing technology, customized skull prostheses have become possible, but how to improve the biocompatibility, bone induction ability and bone ingrowth effect of the prosthesis is still a hot topic in current research. Summary of the invention

[0003] The purpose of the present invention is to provide a personalized 3D printed porous composite hydroxyapatite coating skull prosthesis to solve at least one of the above-mentioned problems existing in the prior art.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] A personalized 3D printed porous composite hydroxyapatite coated skull prosthesis comprises a truss structure, on which a plurality of porous areas are distributed, in which a bionic trabecular structure is integrally formed, the truss structure is composed of interconnected hollow tubes, on which a plurality of small holes and micropores connected to the inside of the hollow tubes are arranged, and the porous area is sprayed with a composite coating of hydroxyapatite coating and titanium.

[0006] This technical solution first conducts individualized design based on the patient's CT scan data to ensure that the shape and size of the prosthesis fully match the patient's skull defect. Then, the prosthesis is produced using 3D printing technology. The structure of the prosthesis includes a truss structure and a porous area distributed on the truss structure. The use of 3D printing technology to produce the prosthesis can ensure that the shape and contour of the prosthesis fully match the skull defect and improve the aesthetics; in addition, the use of 3D printing technology can ensure that complex curved surfaces are formed in one step, improving production efficiency and the molding accuracy of the prosthesis. A bionic trabecular structure is formed in the porous area. The truss structure is composed of interconnected hollow tubes, the hollow tube has a structure with small holes, and the wall thickness of the hollow tube has micropores. Several micropores form a permeable structure. The truss structure composed of hollow tubes facilitates blood transportation and exchange, and enhances bone cell attachment and proliferation. The small holes and microporous structures on the bionic trabecular structure and the truss structure can promote bone cell attachment, proliferation and osteogenesis. The porous structure presented by the bionic trabecular structure in the porous area is sprayed with a composite coating of hydroxyapatite coating and titanium, which can increase the induction of bone cell proliferation and ensure that the porous structure after composite hydroxyapatite has a three-dimensional interconnected structure, which can ensure the multi-dimensional growth of bone cells and achieve high-strength bone fusion and bone integration. The composite coating of hydroxyapatite and titanium can improve the biocompatibility of the restoration, enhance the bone induction ability and bone ingrowth effect, and the hydroxyapatite is converted into part of the bone after being absorbed, thereby enhancing the bone formation ability. In summary, this technical solution has a high degree of individualization, biocompatibility, bone induction ability and bone ingrowth effect.

[0007] Furthermore, in order to achieve a better porous structure forming effect, the porosity of the porous region is 50%-90%, and the pore size is 200-800 microns.

[0008] Furthermore, in order to ensure the stability of the overall structure, the hole shape of the porous area is a hexagonal hole shape.

[0009] Furthermore, in order to better promote bone cell attachment, proliferation and osteogenesis, the diameter of the small hole is 100-300 microns.

[0010] Furthermore, in order to better enhance the osteoinduction ability and bone ingrowth effect, the thickness of the hydroxyapatite coating is 10-50 microns.

[0011] Furthermore, the hydroxyapatite coating and the titanium composite coating are firmly combined through chemical bonding, thereby achieving good biological fixation and functional recovery.

[0012] The present invention also provides a method for making a personalized 3D printed porous composite hydroxyapatite coating skull repair body, which includes the following steps:

[0013] S1. Design the individualized shape of the skull prosthesis based on the patient's CT scan data;

[0014] S2, using 3D printing technology to produce the truss structure and porous areas of the restoration;

[0015] S3. Spraying a hydroxyapatite coating on the surface of the porous area to ensure that the porous area and the hydroxyapatite can be effectively compounded and have a three-dimensional interconnected structure;

[0016] S4. The hydroxyapatite coating and titanium are composited by chemical bonding technology.

[0017] Furthermore, in S3, before spraying the hydroxyapatite coating, the surface of the porous area is pretreated to increase the adhesion of the coating.

[0018] Furthermore, in S4, the chemical bonding technique includes the use of a surfactant and / or heat treatment.

[0019] The beneficial effects of the present invention are as follows: the present technical solution firstly performs individualized design according to the patient's CT scan data to ensure that the shape and size of the prosthesis completely match the patient's skull defect. Then, the prosthesis is produced using 3D printing technology. The structure of the prosthesis includes a truss structure and a porous area distributed on the truss structure. The prosthesis is produced using 3D printing technology to ensure that the shape and contour of the prosthesis completely match the skull defect and improve the aesthetics; in addition, the use of 3D printing technology can ensure that complex curved surfaces are formed in one step, thereby improving production efficiency and the molding accuracy of the prosthesis. A bionic trabecular structure is formed in the porous area. The truss structure is composed of interconnected hollow tubes, the hollow tubes have a structure with small holes, the wall thickness of the hollow tubes has micropores, and a number of micropores form a permeable structure. The truss structure composed of hollow tubes is convenient for blood transportation and exchange, and enhances bone cell attachment and proliferation. The small holes and microporous structures on the bionic trabecular structure and the truss structure can promote bone cell attachment, proliferation and osteogenesis. The porous structure presented by the bionic trabecular structure in the porous area is sprayed with a composite coating of hydroxyapatite coating and titanium, which can increase the induction of bone cell proliferation and ensure that the porous structure after composite hydroxyapatite has a three-dimensional interconnected structure, which can ensure the multi-dimensional growth of bone cells and achieve high-strength bone fusion and bone integration. The composite coating of hydroxyapatite and titanium can improve the biocompatibility of the restoration, enhance the bone induction ability and bone ingrowth effect, and the hydroxyapatite is converted into part of the bone after being absorbed, thereby enhancing the bone formation ability. In summary, this technical solution has a high degree of individualization, biocompatibility, bone induction ability and bone ingrowth effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of the truss structure in the present invention;

[0021] Figure 2 It is a partial enlarged structural schematic diagram of the truss structure in the present invention;

[0022] Figure 3 It is a schematic diagram of the structure of the bionic trabecular distribution after the truss structure part is hidden in the present invention;

[0023] Figure 4 It is a schematic diagram of the structure of the bionic trabecular bone in the present invention;

[0024] Figure 5 It is a structural schematic diagram of the present invention;

[0025] Figure 6 It is a schematic diagram of a local enlarged structure in the present invention.

[0026] In the figure: truss structure 1; hollow tube 1.1; small hole 1.2; porous area 2; bionic bone trabecular structure 3. DETAILED DESCRIPTION

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the present invention will be briefly introduced below in combination with the drawings and the description of the embodiments or the prior art. Obviously, the following description of the structure of the drawings is only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. It should be noted that the description of these embodiments is used to help understand the present invention, but does not constitute a limitation of the present invention.

[0028] Embodiment 1:

[0029] like Figure 1-Figure 6 As shown, this embodiment provides a personalized 3D printed porous composite hydroxyapatite coated skull prosthesis, including a truss structure 1, on which are distributed a plurality of porous regions 2, the porous regions 2 being surrounded by the frame of the truss structure 1, and in order to ensure the stability of the overall structure, the hole pattern of the porous regions 2 is a hexagonal hole pattern, that is, the frame of the truss structure 1 surrounds a plurality of hexagonal porous regions 2, the thickness of the truss structure 1 is the same as that of the porous regions 2, and the truss structure 1 and the porous regions 2 are equivalent to partition descriptions of different forms on the same structure, and the two are not separable structures. A bionic trabecular structure 3 is integrally formed in the porous area 2, that is, the porous area 2 is the forming range of the bionic trabecular structure 3, and the bionic trabecular structure 3 and the truss structure 1 are also inseparable structures. The two are integrally formed, and the truss structure 1 is composed of hollow tubes 1.1 that are interconnected. The hollow tubes 1.1 are provided with a plurality of small holes 1.2 and micropores (not shown in the figure) that are connected to the inside of the hollow tubes 1.1, and the porous area 2 is sprayed with a composite coating of hydroxyapatite coating and titanium.

[0030] This technical solution firstly carries out individualized design according to the patient's CT scan data to ensure that the shape and size of the prosthesis completely match the patient's skull defect. Then, the prosthesis is produced by 3D printing technology. The structure of the prosthesis includes a truss structure 1 and a porous area 2 distributed on the truss structure 1. The prosthesis produced by 3D printing technology can ensure that the shape and contour of the prosthesis completely match the skull defect and improve the aesthetics; in addition, the use of 3D printing technology can ensure that complex curved surfaces are formed in one time, improve production efficiency and the molding accuracy of the prosthesis. A bionic trabecular structure 3 is formed in the porous area 2. The truss structure 1 is composed of interconnected hollow tubes 1.1. The hollow tube 1.1 has a structure with small holes 1.2. The wall thickness of the hollow tube 1.1 has micropores. Several micropores form a permeable structure. The truss structure 1 formed by the hollow tube 1.1 is convenient for blood transportation and exchange, and enhances bone cell attachment and proliferation. The bionic trabecular structure 3 and the small holes 1.2 and microporous structure on the truss structure 1 can promote bone cell attachment, proliferation and osteogenesis. The porous structure presented by the bionic trabecular structure 3 of the porous area 2 is sprayed with a composite coating of hydroxyapatite coating and titanium, which can increase the induction of bone cell proliferation and ensure that the porous structure after composite hydroxyapatite has a three-dimensional interconnected structure, which can ensure the multi-dimensional growth of bone cells and achieve high-strength bone fusion and bone integration. The composite coating of hydroxyapatite and titanium can improve the biocompatibility of the restoration, enhance the bone induction ability and bone ingrowth effect, and the hydroxyapatite is converted into a part of the bone after being absorbed, thereby enhancing the bone formation ability. In summary, this technical solution has a high degree of individualization, biocompatibility, bone induction ability and bone ingrowth effect.

[0031] Embodiment 2:

[0032] This embodiment is optimized based on the above-mentioned embodiment 1.

[0033] In order to achieve a better porous structure forming effect, the porosity of the porous region 2 is 50%-90%, and the pore size is 200-800 microns.

[0034] Embodiment 3:

[0035] This embodiment is optimized based on the above-mentioned embodiment 1.

[0036] In order to better promote bone cell attachment, proliferation and osteogenesis, the diameter of the small hole 1.2 is 100-300 microns.

[0037] Embodiment 4:

[0038] This embodiment is optimized based on the above-mentioned embodiment 1.

[0039] In order to better enhance the osteoinduction ability and bone ingrowth effect, the thickness of the hydroxyapatite coating is 10-50 microns.

[0040] Embodiment 5:

[0041] This embodiment is optimized based on the above-mentioned embodiment 1.

[0042] The composite coating of hydroxyapatite coating and titanium is firmly combined through chemical bonding, achieving good biological fixation and functional recovery.

[0043] Embodiment 6:

[0044] The present invention also provides a method for making a personalized 3D printed porous composite hydroxyapatite coating skull repair body, which includes the following steps:

[0045] S1. Design the individualized shape of the skull prosthesis based on the patient's CT scan data;

[0046] S2, using 3D printing technology to produce a truss structure 1 and a porous area 2 of the restoration, wherein the porous area 2 is printed as a bionic trabecular structure 3;

[0047] S3, spraying a hydroxyapatite coating on the surface of the porous region 2 to ensure that the porous region 2 and the hydroxyapatite can be effectively compounded and have a three-dimensional interconnected structure;

[0048] S4. The hydroxyapatite coating and titanium are composited by chemical bonding technology.

[0049] Embodiment 7:

[0050] This embodiment is optimized based on the above-mentioned embodiment 6.

[0051] In S3, before spraying the hydroxyapatite coating, the surface of the porous region 2 is pretreated to increase the adhesion of the coating.

[0052] Embodiment 8:

[0053] This embodiment is optimized based on the above-mentioned embodiment 6.

[0054] In S4, the chemical bonding technique includes the use of a surfactant and / or a heat treatment.

[0055] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A personalized 3D printed porous composite hydroxyapatite coated skull prosthesis, characterized in that: It comprises a truss structure, on which a plurality of porous areas are distributed, in which a bionic trabecular structure is integrally formed, the truss structure is composed of hollow tubes interconnected with each other, on which a plurality of small holes and micropores connected with the inside of the hollow tubes are arranged, and the porous areas are sprayed with a composite coating of hydroxyapatite coating and titanium.

2. The personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 1, characterized in that: The porosity of the porous region is 50%-90%, and the pore size is 200-800 microns.

3. The personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 1, characterized in that: The pore shape of the porous area is a hexagonal pore shape.

4. The personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 1, characterized in that: The diameter of the small hole is 100-300 microns.

5. The personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 1, characterized in that: The thickness of the hydroxyapatite coating is 10-50 microns.

6. The personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 1, characterized in that: The hydroxyapatite coating and the titanium composite coating are firmly combined through chemical bonding.

7. A method for making a personalized 3D printed porous composite hydroxyapatite coating skull prosthesis, characterized in that: The following steps are involved: S1. Design the individualized shape of the skull prosthesis based on the patient's CT scan data; S2, using 3D printing technology to produce the truss structure and porous areas of the restoration; S3. Spraying a hydroxyapatite coating on the surface of the porous area to ensure that the porous area and the hydroxyapatite can be effectively compounded and have a three-dimensional interconnected structure; S4. The hydroxyapatite coating and titanium are composited by chemical bonding technology.

8. The method for making a personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 7, characterized in that: In S3, before spraying the hydroxyapatite coating, the surface of the porous area is pretreated to increase the adhesion of the coating.

9. The method for making a personalized 3D printed porous composite hydroxyapatite coating skull prosthesis according to claim 7, characterized in that: In S4, the chemical bonding technique includes the use of a surfactant and / or a heat treatment.

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