Mixing device and method for preparing dihydroergoline mesylate raw materials

Abstract

The invention discloses a device and a method for preparing and mixing dihydroergoline mesylate raw materials, and relates to the technical field of pharmaceutical engineering.The device and the method for preparing and mixing the dihydroergoline mesylate raw materials comprise a fixed support, and a stirring material box is rotatably connected to the interior of the fixed support; a feeding mechanism for ensuring smooth feeding of various component compounds is arranged in the stirring material box, a scattering mechanism for dispersing and preparing various component compounds in a dihydroergoline mesylate raw material is arranged in the stirring material box, and a cleaning mechanism for cleaning a discharging barrel is arranged in the stirring material box; through cooperative use of the feeding mechanism and the cleaning mechanism, the cleaning mechanism automatically cleans the discharging barrel on the surface of the switching circular plate, the problem that an existing discharging barrel cleaning mode is low in efficiency is solved, and compared with manual cleaning, the cleaning efficiency of the discharging barrel can be improved by automatically cleaning the discharging barrel of the switching circular plate through the cleaning mechanism; and operators can be prevented from being in direct contact with the compounds through automatic cleaning.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical engineering, in particular to a mixing device and a method for preparing dihydroergotamine mesylate raw materials. Background Art

[0002] Ergot mesylate is an alkaloid drug, which is mainly used to improve the symptoms of mental degeneration related to aging. In the preparation process of ergot mesylate raw materials, mixing is a key link. The traditional manual mixing method has problems such as uneven mixing, low efficiency, and easy introduction of impurities, which will affect the quality and output of the product. Therefore, a more advanced, efficient and precise mixing device is used to meet the needs of the preparation of ergot mesylate raw materials. By adopting advanced mixing technology and design, the four compounds in the preparation of ergot mesylate raw materials can be fully mixed to ensure that the composition of the mixture is uniform, thereby improving the quality and stability of the product.

[0003] There are still many inconveniences in the use of current equipment; The specific defects are as follows: First, during the feeding process, since the four compounds in the preparation of dihydroergotamine mesylate raw materials have large surface tension and certain viscosity, they are easy to adhere to the solid surface. After the compounds are fed for a long time, some compounds will adhere to the inner wall of the discharge barrel due to their own viscosity, and the compounds attached to the inner wall of the discharge tube will hinder the subsequent feeding of the compounds, thereby affecting the feeding speed. In order to ensure the smooth feeding of the compounds, the discharge barrel needs to be cleaned after a period of use. The existing cleaning method requires stopping the machine and then cleaning the discharge barrel with a detergent and a brush. This shutdown cleaning method greatly affects the preparation efficiency of dihydroergotamine mesylate raw materials, and more time and resources are required to produce the same amount of dihydroergotamine mesylate raw materials, thereby increasing production costs.

[0004] Secondly, since the four compounds in the raw materials for preparing dihydroergot mesylate have certain viscosity or surface activity, during the process of being put into the mixing device, the compounds for preparing dihydroergot mesylate are easily attached or adhered to each other to form larger agglomerates. The compounds for preparing dihydroergot mesylate cannot be quickly dispersed after being put into the device, resulting in uneven mixing of the four compounds for preparing dihydroergot mesylate during the stirring process, thereby affecting the quality of the dihydroergot mesylate raw material.

[0005] Therefore, the present invention provides a mixing device and method for preparing dihydroergotamine mesylate raw materials to make up for and improve the shortcomings of the prior art. Summary of the invention

[0006] 1. Technical issues to be resolved In view of the deficiencies in the prior art, the present invention provides a mixing device and method for preparing dihydroergot mesylate raw materials, which solves the problems that the existing cleaning method for the discharge barrel proposed in the above background technology is inefficient and the compounds in the preparation of dihydroergot mesylate raw materials are located inside the device and are accumulated, thereby making it difficult to mix the four compounds in the preparation of dihydroergot mesylate raw materials evenly during the stirring process.

[0007] (II) Technical solution To achieve the above purpose, the present invention is implemented by the following technical scheme: a mixing device for preparing dihydroergotamine mesylate raw materials, comprising a fixed support, the interior of the fixed support is rotatably connected to a stirring box, characterized in that: the interior of the stirring box is provided with a feeding mechanism to ensure smooth feeding of each component compound, the interior of the stirring box is provided with a scattering mechanism for dispersing each component compound in the preparation of dihydroergotamine mesylate raw materials, and the interior of the stirring box is provided with a cleaning mechanism for cleaning a lower barrel; The feeding mechanism includes a storage container for storing raw materials, and the feeding mechanism also includes a switching circular plate for unloading part of the compounds in the storage container; The scattering mechanism includes a push piston that pumps external gas to blow away the compound agglomerates that are stuck together, so that each component compound is dispersed in the stirring area, the scattering mechanism also includes a second slider and a first slider that drive the push piston to slide and then extract external gas, and the scattering mechanism also includes a second spring that pushes the push piston to slide and pushes the gas in the device to the falling path of the compound agglomerates; The cleaning mechanism includes a cleaning circular shaft for cleaning the inside of the switching circular plate, and the cleaning mechanism also includes a switching circular shaft for adjusting the sliding state of the cleaning circular shaft.

[0008] Preferably, the feeding mechanism includes a power gear, the power gear is rotatably connected to the interior of the mixing box, the interior of the mixing box is rotatably connected to a connecting gear, the power gear and the connecting gear are meshed with each other, the upper surface of the connecting gear is fixedly connected to a connecting support rod, the switching circular plate is fixedly connected to one end surface of the connecting support rod, the storage container is fixedly connected to the upper surface of the mixing box, the surface of the switching circular plate is fixedly connected to a discharge barrel, and the discharge barrel on the surface of the switching circular plate is connected to the discharge port of the storage container.

[0009] Preferably, the feeding mechanism includes a power gear, the power gear is rotatably connected to the interior of the mixing box, the interior of the mixing box is rotatably connected to a connecting gear, the power gear and the connecting gear are meshed, the upper surface of the connecting gear is fixedly connected to a connecting support rod, the switching circular plate is fixedly connected to one end of the connecting support rod, the storage container is fixedly connected to the upper surface of the mixing box, the surface of the switching circular plate is fixedly connected to a discharge barrel, and the discharge barrel on the surface of the switching circular plate is connected to the discharge port of the storage container.

[0010] Preferably, two material storage containers are provided, and the two material storage containers are symmetrically arranged on the upper surface of the fixed support. Two material barrels are provided under the surface of the switching circular plate, and the two material barrels under the surface of the switching circular plate are symmetrically arranged with the connecting support rod as the axis.

[0011] Preferably, the transmission ratio between the power gear and the connecting rod is one to one, and the surface of the power gear has only a half circle of gear blocks.

[0012] The cam is connected with two guide wheels, and the guide wheels are connected with two guide wheels internally to your wheelchair, and the two guide wheels are connected with two guide wheels internally to your wheelchair.

[0013] Preferably, one end of the switching block is arranged as an inclined surface, and one end of the driving slider is arranged as an inclined surface, and the inclined surface of the switching block is in contact with the inclined surface of the driving slider.

[0014] Preferably, the switching block is located inside the sliding path of the driving slider, the driving slider is located inside the sliding path of the fixed block, the thickness of the fixed block and the switching block are both half the thickness of the driving slider, and the fixed block and the switching block are not in the same horizontal plane.

[0015] Preferably, the cleaning mechanism includes a No. 1 gear, the No. 1 gear is rotatably connected to the inside of the mixing box, the switching circular shaft is rotatably connected to the inside of the mixing box, the No. 1 gear is meshed with the power gear, the switching circular shaft is fixedly connected to the No. 1 gear, the cleaning circular shaft is slidably connected to the inside of the mixing box, the inside of the cleaning circular shaft is slidably connected with a sliding coupling, the inside of the cleaning circular shaft is fixedly connected with a No. 3 spring, the No. 3 spring is fixedly connected to the sliding coupling, the surface of the switching circular shaft is provided with an inclined groove and a straight groove, the sliding coupling is slidably connected to the inside of the inclined groove and the straight groove on the surface of the switching circular shaft, the cleaning circular shaft is slidably connected to the inside of the barrel under the surface of the switching circular plate, the inside of the mixing box is fixedly connected with a No. 4 spring, and the No. 4 spring is fixedly connected to the cleaning circular shaft.

[0016] Preferably, the straight slide groove on the surface of the switching circular shaft is connected to the oblique slide groove, and the depth of the oblique slide groove on the surface of the switching circular shaft is greater than the depth of the straight slide groove on the surface of the switching circular shaft.

[0017] A method for mixing dihydroergotamine mesylate raw materials comprises the following steps: S1. Raw material preparation step: the dihydroergoline mesylate raw material is prepared from four compounds: dihydroergocortin mesylate, dihydroergoline mesylate, dihydro-α-ergocryptine mesylate and dihydro-β-ergocryptine mesylate. The discharge ports of two storage containers containing different compounds are aligned and fixed with the discharge trough on the surface of the stirring box. The four compounds are synchronously fed into the raw material stirring area by switching the discharge barrel on the surface of the circular plate; S2, material mixing step: the four compounds are driven by the feeding mechanism to enter the stirring area inside the stirring box, and the four compounds disperse the agglomerates of the component compounds through the scattering mechanism during the falling process, and the dispersed component compounds are initially mixed, and then stirred by the stirrer inside the stirring box; S3, packaging and storage step: the mixed dihydroergotamine mesylate raw material is taken out from the mixing equipment, packaged or enters the next production process, and the mixing equipment is cleaned and disinfected to prevent cross contamination.

[0018] (III) Beneficial effects The mixing device and method for preparing dihydroergotamine mesylate raw materials provided by the present invention have the following beneficial effects: 1. The invention realizes intermittent feeding of four compounds for preparing dihydroergot mesylate raw materials in a storage container by coordinating the use of a stirring box and a feeding mechanism and switching the intermittent rotation of a circular plate, thereby solving the problem that each component compound is continuously fed into a mixing device and each component compound accumulates in a stirring area. The feeding speed is controlled by controlling the feeding time and the interval time, thereby ensuring that each component compound entering the mixing device is always kept within a suitable range, and intermittent feeding can avoid the accumulation of each component compound at a certain position of the mixing device, thereby preventing the local concentration of a certain compound from being too high in the preparation process of dihydroergot mesylate raw materials.

[0019] 2. Through the coordinated use of the feeding mechanism and the dispersing mechanism, the gas inside the ventilation groove is pushed into the stirring area, and then the compound agglomerates that are stuck together are blown away, so that the component compounds are dispersed in the stirring area, which solves the problem that the component compounds are piled up inside the device, resulting in excessive concentration of a single compound at a certain position inside the device. The airflow can quickly disperse the four compounds to various parts of the mixing device, so that the component compounds are more fully mixed in the stirring area of ​​the device, thereby improving the uniformity of the mixing and ensuring the consistency of product quality. In addition, the airflow dispersion can effectively break the agglomerates and lumps of the component compounds, so that the component compounds maintain a good dispersion state, which is beneficial to the subsequent reaction and processing of the component compounds. In addition, multiple compounds are discharged simultaneously, and the multiple compounds are blown away simultaneously through the dispersing mechanism, so as to achieve the purpose of initial mixing of multiple compounds.

[0020] 3. Through the coordinated use of the feeding mechanism and the cleaning mechanism, the cleaning mechanism automatically cleans the lower barrel on the surface of the switching circular plate, thereby solving the problem of low efficiency of the existing lower barrel cleaning method. Compared with manual disassembly and cleaning, the method of automatically cleaning the switching circular plate lower barrel by the cleaning mechanism can greatly improve the cleaning efficiency of the lower barrel, reduce cleaning time and labor costs, and the automatic cleaning method can avoid direct contact between operators and component compounds, thereby reducing the harm of compounds to operators and the pollution of the component compounds to the outside world.

[0021] 4. Through the coordinated use of the feeding mechanism and the cleaning mechanism, during the intermittent switching of the two discharge barrels on the surface of the circular plate, the cleaning mechanism will clean the used discharge barrels, ensuring the continuity and stability of each discharge of each component compound, and avoiding the problem of the component compounds attached to the inner wall of the discharge barrel deteriorating and then contaminating the four compounds in the stirring area inside the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2It is a schematic diagram of the internal structure of the present invention; Figure 3 It is a position relationship diagram of the feeding mechanism and the scattering mechanism of the present invention; Figure 4 It is a schematic diagram of the overall structure of the feeding mechanism of the present invention; Figure 5 It is a schematic diagram of the overall structure of the scattering mechanism of the present invention; Figure 6 For the present invention Figure 5 A partial enlarged view of middle A; Figure 7 It is a schematic diagram of the internal structure of the scattering mechanism of the present invention; Figure 8 It is a schematic diagram of the overall structure of the scattering mechanism of the present invention; Fig. 9 For the present invention Figure 8 A partial enlarged view of B.

[0023] The numbers in the figure represent: 1. Fixed support; 2. Mixing material box; 3. Feeding mechanism; 311. Power gear; 312. Connecting gear; 313. Connecting support rod; 314. Switching circular plate; 315. Material storage container; 4. Dispersion mechanism; 411. Bottom rotating plate; 412. Driving sliding frame; 413. Sliding block No. 1; 414. Fixed stop block; 415. Sliding block No. 2; 416. Driving sliding block; 417. Spring No. 1; 418. Switching stop block; 419. Pushing piston; 4110. Spring No. 2; 4111. Pulling shaft; 5. Cleaning mechanism; 511. Switching circular shaft; 512. Cleaning circular shaft; 513. Gear No. 1; 514. Spring No. 3; 515. Sliding coupling; 516. Spring No. 4. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] refer to Figures 1 to 9According to a preferred embodiment of the present invention, a dihydroergotamine mesylate raw material preparation mixing device and method will be described in detail below. The dihydroergotamine mesylate raw material preparation mixing device comprises a fixed support 1, and a stirring material box 2 is rotatably connected inside the fixed support 1, characterized in that: the stirring material box 2 is provided with a feeding mechanism 3 to ensure smooth feeding of each component compound, the stirring material box 2 is provided with a scattering mechanism 4 for dispersing each component compound in the preparation of dihydroergotamine mesylate raw material, and the stirring material box 2 is provided with a cleaning mechanism 5 for cleaning the lower barrel; The feeding mechanism 3 includes a storage container 315 for storing raw materials, and the feeding mechanism 3 also includes a switching circular plate 314 for unloading part of the compound in the storage container 315; The dispersing mechanism 4 includes a push piston 419 that pumps external gas to blow away the compound agglomerates that are stuck together, so that each component compound is dispersed in the stirring area. The dispersing mechanism 4 also includes a second slider 415 and a first slider 413 that drive the push piston 419 to slide and then extract external gas. The dispersing mechanism 4 also includes a second spring 4110 that pushes the push piston 419 to slide and pushes the gas in the device to the falling path of the compound agglomerates. The cleaning mechanism 5 includes a cleaning circular shaft 512 for cleaning the inside of the switching circular plate 314 , and the cleaning mechanism 5 also includes a switching circular shaft 511 for adjusting the sliding state of the cleaning circular shaft 512 .

[0026] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, Figure 3In the embodiment, the feeding mechanism 3 includes a power gear 311, which is rotatably connected to the inside of the mixing box 2. A motor is arranged inside the mixing box 2, and a transmission shaft plate is arranged at one end of the motor output shaft. The transmission shaft plate and the surface of the power gear 311 are connected with a transmission track. The motor drives the power gear 311 to rotate through the transmission track. The inside of the mixing box 2 is rotatably connected with a connecting gear 312. The power gear 311 and the connecting gear 312 are meshed. The upper surface of the connecting gear 312 is fixedly connected with a connecting support rod 313. A switching circular plate 314 is fixedly connected to one end surface of the connecting support rod 313. A storage container 315 is fixedly connected to the upper surface of the mixing box 2. The surface of the switching circular plate 314 is fixedly connected with a discharge barrel. The unloading barrel on the surface of the switching circular plate 314 is connected to the unloading port of the storage container 315. Two storage containers 315 are provided. The two storage containers 315 are symmetrically arranged on the upper surface of the fixed support 1. Two unloading barrels are provided. The two unloading barrels are symmetrically arranged with the connecting support rod 313 as the axis. The power gear 311 drives the connecting gear 312 to rotate. Since the connecting gear 312 and the switching circular plate 314 are fixedly connected with the connecting support rod 313, and two unloading barrels are arranged on the surface of the switching circular plate 314, the switching circular plate 314 is driven by the connecting support rod 313 to rotate, thereby separating the unloading barrel with each component compound attached from the aligned state of the unloading port of the storage container 315, and aligning the other unloading barrel with the unloading mechanism of the storage container 315 for unloading, such as Figure 4 In the embodiment, the transmission ratio of the power gear 311 and the connecting support rod 313 is one to one. Since there is only a half-circle gear block on the surface of the power gear 311, the power gear 311 rotates one circle and the switching circular plate 314 rotates half a circle, thereby realizing the intermittent switching of the two discharge barrels. By switching the connection state between the discharge barrel of the circular plate 314 and the discharge port of the storage container 315, and coordinating with the intermittent rotation of the switching circular plate 314, the intermittent discharge of each component compound inside the storage container 315 can be realized.

[0027] like Figure 5 , Figure 6 and Figure 7 As shown, Figure 5 In the embodiment, the dispersion mechanism 4 includes two bottom rotating plates 411, and the two bottom rotating plates 411 are fixedly connected to the lower surface of the power gear 311. The lower surface of the bottom rotating plates 411 is fixedly connected to the pulling shaft 4111. When the power gear 311 rotates, the pulling shaft 4111 fixedly connected to the bottom of the bottom rotating plate 411 is driven to rotate through the bottom rotating plates 411, thereby driving the pulling shaft 4111 to slide inside the driving slide frame 412, thereby driving the driving slide frame 412 to slide, as shown in FIG. Figure 5In the embodiment, the interior of the mixing box 2 is slidably connected to two driving sliding frames 412, and the pulling shaft 4111 is slidably connected to the interior of the driving sliding frame 412. The interior of the mixing box 2 is slidably connected to two No. 1 sliders 413, the driving sliding frame 412 is fixedly connected to the No. 1 slider 413, the No. 2 slider 415 is slidably connected to the interior of the mixing box 2, the air push piston 419 is fixedly connected to one end of the No. 2 slider 415, the No. 2 spring 4110 is fixedly connected to the interior of the mixing box 2, the No. 2 spring 4110 is fixedly connected to the No. 2 slider 415, and the lower surface of the No. 1 slider 413 The first slider 413 slides under the drive of the sliding frame 412, so that the first slider 413 drives the driving slider 416 to give a thrust to push the second slider 415 to slide, so that the second slider 415 drives the air-pushing piston 419 to slide away from the surface of the mixing box 2. Since the mixing box 2 is provided with a ventilation groove inside and a one-way valve opened inward is provided at one end of the ventilation groove, the air-pushing piston 419 slides toward the mixing area under the drive of the second slider 415, so that the external gas is placed inside the ventilation groove. Figure 6 and Figure 7 In the embodiment, the interior of the No. 2 slider 415 is slidably connected with a driving slider 416, the interior of the No. 2 slider 415 is fixedly connected with a No. 1 spring 417, the No. 1 spring 417 is fixedly connected to the driving slider 416, and the interior of the mixing box 2 is fixedly connected with a switching stop block 418, the inclined surface of the driving slider 416 fits the inclined surface of the switching stop block 418, the driving slider 416 is pushed by the switching stop block 418, the No. 1 spring 417 is compressed under the push of the driving slider 416, the driving slider 416 extends to the interior of the No. 2 slider 415, the driving slider 416 does not contact the fixed stop block 414, the No. 2 slider 415 loses the restriction of the fixed stop block 414, and the No. 2 slider 415 slides away from the mixing area under the push of the No. 2 spring 4110, thereby pushing the air pusher. The piston 419 slides, and due to the gas filled inside the ventilation groove, the gas inside the ventilation groove is pushed into the stirring area, thereby forming an airflow in the falling path of the compound agglomerates, and then blowing away the compound agglomerates that are stuck together, so that the four compounds are dispersed in the stirring area, one end of the switching stop block 418 is set as an inclined surface, and one end of the driving slider 416 is set as an inclined surface, the inclined surface of the switching stop block 418 is in contact with the inclined surface of the driving slider 416, the switching stop block 418 is located inside the sliding path of the driving slider 416, and the driving slider 416 is located inside the sliding path of the fixed stop block 414, the thickness of the fixed stop block 414 and the thickness of the switching stop block 418 are both half of the thickness of the driving slider 416, and the fixed stop block 414 and the switching stop block 418 are not in the same horizontal plane.

[0028] Further embodiment: a ventilation groove is provided inside the mixing material box 2, and a one-way valve opening inwards is provided at one end of the ventilation groove, and the other end of the ventilation groove is connected to the mixing area and is provided with a one-way valve opening outwards.

[0029] The effect achieved by this embodiment is as follows: the external gas is guided into the stirring area through the sliding direction of the air push piston 419.

[0030] like Figure 8 and Fig. 9 As shown, Figure 8 In the embodiment, the cleaning mechanism 5 includes a No. 1 gear 513, the No. 1 gear 513 is rotatably connected to the inside of the mixing box 2, the switching shaft 511 is rotatably connected to the inside of the mixing box 2, the No. 1 gear 513 is meshed with the power gear 311, the switching shaft 511 is fixedly connected to the No. 1 gear 513, the cleaning shaft 512 is slidably connected to the inside of the mixing box 2, and the cleaning shaft 512 is slidably connected to the inside of the unloading barrel on the surface of the switching circular plate 314. When the tooth block on the surface of the power gear 311 rotates to the other side, the unloading barrel of the switching circular plate 314 is aligned with the discharge port of the storage container 315, and the device is in the unloading state, and the No. 1 gear 513 rotates under the drive of the power gear 311. Since the sliding connecting shaft 515 is slidably connected to the switching circular shaft 51 1, the switching shaft 511 rotates to give a downward force to the sliding coupling 515 inside the inclined groove, thereby pushing the cleaning shaft 512 to slide downward, and the cleaning shaft 512 slides downward to compress the No. 4 spring 516. Since the cleaning shaft 512 is slidably connected to the inside of the switching circular plate 314, the cleaning shaft 512 slides inside the switching circular plate 314 under the push of the sliding coupling 515, and then pushes the various component compounds attached to the surface of the switching circular plate 314 to the storage tank inside the mixing box 2, so as to collect the compounds attached to the surface of the switching circular plate 314, and ensure that the inner wall of the barrel under the surface of the switching circular plate 314 is always in a clean state, so as to ensure smooth compound discharge. Fig. 9In the embodiment, a sliding coupling 515 is slidably connected to the inside of the cleaning circular shaft 512, and a No. 3 spring 514 is fixedly connected to the inside of the cleaning circular shaft 512, and the No. 3 spring 514 is fixedly connected to the sliding coupling 515. An inclined slide groove and a straight slide groove are provided on the surface of the switching circular shaft 511, and the sliding coupling 515 is slidably connected to the inside of the inclined slide groove and the straight slide groove on the surface of the switching circular shaft 511. A No. 4 spring 516 is fixedly connected to the inside of the stirring material box 2, and the No. 4 spring 516 is fixedly connected to the cleaning circular shaft 512. The straight slide groove on the surface of the switching circular shaft 511 is connected to the inclined slide groove, and the depth of the inclined slide groove on the surface of the switching circular shaft 511 is greater than the depth of the straight slide groove on the surface of the switching circular shaft 511. When the sliding coupling 515 slides to the bottom of the inclined groove of the switching circular shaft 511, the power The tooth block on the surface of gear 311 does not contact gear No. 1 513. Since there is only a half-circle tooth block on the surface of the power gear 311, when the power gear 311 rotates one circle, the power gear 311 is briefly stopped under the drive of the motor. At this time, the discharge barrel on the surface of the switching circular plate 314 and the discharge port of the storage container 315 are still in an aligned state. At the same time, since the depth of the inclined groove on the surface of the switching circular shaft 511 is greater than the depth of the straight groove, the fourth spring 516 pushes the cleaning circular shaft 512 to slide upward. The sliding coupling 515 is pushed by the straight groove of the switching circular shaft 511 to compress the No. 3 spring 514, and the sliding coupling 515 slides inside the cleaning circular shaft 512 until it is pushed back to the top of the inclined groove on the surface of the switching circular shaft 511.

[0031] A method for mixing dihydroergotamine mesylate raw materials comprises the following steps: S1, raw material preparation step: the dihydroergoline mesylate raw material is prepared from four compounds: dihydroergocortin mesylate, dihydroergoline mesylate, dihydro-α-ergocryptine mesylate and dihydro-β-ergocryptine mesylate. The discharge ports of two storage containers 315 containing different compounds are aligned and fixed with the discharge trough on the surface of the stirring box 2. The four compounds are synchronously fed into the raw material stirring area by switching the discharge barrel on the surface of the circular plate 314. S2, material mixing step: the four compounds are driven by the feeding mechanism 3 to enter the stirring area inside the stirring box 2, and the four compounds are dispersed by the scattering mechanism 4 during the falling process to disperse the agglomerates of the component compounds, and the dispersed component compounds are initially mixed, and then stirred by the stirrer inside the stirring box 2; S3, packaging and storage step: the mixed dihydroergotamine mesylate raw material is taken out from the mixing equipment, packaged or enters the next production process, and the mixing equipment is cleaned and disinfected to prevent cross contamination.

[0032] The effects achieved by this embodiment are as follows: The following is the entire working process and working principle of the above embodiment: Initially: the switching circular plate 314 discharge barrel is aligned with the discharge port of the storage container 315, the fixed stop block 414 is located on the side that drives the sliding block 416 away from the No. 2 spring 4110, the No. 1 spring 417 and the No. 2 spring 4110 are in an uncompressed state, the sliding coupling 515 is at the top of the inclined slide groove on the surface of the switching circular shaft 511, the No. 3 spring 514 and the No. 4 spring 516 are in an uncompressed state, and the cleaning circular shaft 512 is located above the discharge barrel of the switching circular plate 314 and is aligned with the discharge barrel.

[0033] During operation: after a period of use, a certain amount of raw materials are attached to the side wall of the discharge barrel of the switching circular plate 314. In order to ensure the smooth discharge of the various component compounds inside the storage container 315, a motor is arranged inside the mixing box 2, and a transmission shaft plate is arranged at one end of the motor output shaft. The transmission shaft plate and the surface of the power gear 311 are connected by a transmission track. The motor drives the power gear 311 to rotate through the transmission track, and the power gear 311 rotates, thereby driving the connecting gear 312 to rotate. Since a connecting support rod 313 is fixedly connected between the connecting gear 312 and the switching circular plate 314, and two discharge barrels are arranged on the surface of the switching circular plate 314, the switching circular plate 314 is driven by the connecting support rod 313 to rotate, thereby separating the discharge barrel with the various component compounds attached thereto from the aligned state of the discharge port of the storage container 315, and aligning the other discharge barrel with the discharge mechanism of the storage container 315 for discharge. Since there are only half of the tooth blocks on the surface of the power gear 311, the power gear 311 rotates one circle of the switching circle The plate 314 rotates half a circle, thereby realizing intermittent switching of the two discharge barrels. Since the discharge port of the storage container 315 is not connected to the discharge barrel of the switching circular plate 314 during the rotation of the connecting gear 312, until the discharge barrel of the switching circular plate 314 and the storage container 315 are connected again for discharge, the connection state between the discharge barrel of the switching circular plate 314 and the discharge port of the storage container 315 is switched, and the intermittent rotation of the switching circular plate 314 is used to realize intermittent discharge of each component compound in the storage container 315, thereby solving the problem that each component compound is continuously discharged in the mixing device and each component compound will accumulate in the stirring area. The discharge speed of each component compound is controlled by controlling the discharge time and the interval time, thereby ensuring that the amount of each component compound in the mixing device is always kept within a suitable range, and intermittent discharge can avoid the accumulation of a single component compound at a certain position of the mixing device, thereby causing the local concentration of the compound to be too high at a certain position during the stirring process. Furthermore, the lower surface of the bottom rotating plate 411 is fixedly connected with a pulling shaft 4111, and the power gear 311 rotates, and the pulling shaft 4111 fixedly connected to the bottom of the bottom rotating plate 411 is driven to rotate through the bottom rotating plate 411, thereby driving the pulling shaft 4111 to slide inside the driving sliding frame 412, thereby driving the driving sliding frame 412 to slide, and the lower surface of the No. 1 slider 413 is fixedly connected with a fixed stop block 414, and the No. 1 slider 413 drives the sliding frame 412 with a belt The first slider 413 drives the driving slider 416 to give a thrust to push the second slider 415 to slide, thereby driving the air-pushing piston 419 to slide away from the surface of the mixing box 2 through the second slider 415. Since the mixing box 2 is provided with a venting groove inside and a one-way valve opened inwardly is provided at one end of the venting groove, the air-pushing piston 419 slides toward the mixing area under the drive of the second slider 415, thereby introducing the external gas into the venting groove; At the same time, the interior of the mixing box 2 is fixedly connected with a switching stop block 418, which drives the inclined surface of the slider 416 to fit with the inclined surface of the switching stop block 418. Under the push of the switching stop block 418, the No. 1 spring 417 is compressed under the push of the slider 416, and the slider 416 extends to the interior of the No. 2 slider 415. The slider 416 does not contact the fixed stop block 414, and the No. 2 slider 415 loses the restriction of the fixed stop block 414. Under the push of the No. 2 spring 4110, the No. 2 slider 415 slides away from the mixing area, thereby pushing the air piston 419 to slide. Since the ventilation groove is filled with gas, the gas inside the ventilation groove is pushed into the stirring area, and then the agglomerates of the compounds stuck together are blown away, so that the four compounds are dispersed in the stirring area, which solves the problem of accumulation of each component compound inside the device, resulting in excessive concentration of a single compound at a certain position inside the device. The airflow can quickly disperse the four compounds to various parts of the mixing device, so that the component compounds are more fully mixed in the stirring area of ​​the device, thereby improving the uniformity of mixing of the component compounds and ensuring the consistency of the quality of the dihydroergotamine mesylate raw material.

[0034] Furthermore, when the tooth block on the surface of the power gear 311 rotates to the other side, the switching circular plate 314 is aligned with the discharge port of the storage container 315, and the device is in a discharging state, and the No. 1 gear 513 rotates under the drive of the power gear 311. Since the sliding coupling 515 is slidably connected to the straight groove and the inclined groove on the surface of the switching circular shaft 511, the switching circular shaft 511 rotates to give the sliding coupling 515 in the inclined groove a downward force, thereby pushing the cleaning circular shaft 512 to slide downward. The cleaning circular shaft 512 slides downward to push the No. 4 spring 516 to compress. The cleaning shaft 512 slides inside the switching circular plate 314 under the push of the sliding connecting shaft 515. A pushing block is slidably connected inside the mixing box 2. A material storage groove is provided on the surface of the pushing block inside the mixing box 2. The material storage groove is located below the barrel under the surface of the switching circular plate 314, and then the component compounds attached to the surface of the switching circular plate 314 are pushed into the material storage groove inside the mixing box 2. The pushing block slidably connected to the mixing box 2 is manually pulled out to take out the component compounds that fall into the material storage groove. When the sliding connecting shaft 515 slides to the bottom of the inclined groove of the switching circular shaft 511, the dynamic The tooth block on the surface of the power gear 311 does not contact the No. 1 gear 513. Since the surface of the power gear 311 has only a half-circle tooth block, when the power gear 311 rotates one circle, the power gear 311 is briefly stopped under the drive of the motor. At this time, the discharge barrel on the surface of the switching circular plate 314 and the discharge port of the storage container 315 are still in an aligned state. At the same time, since the depth of the inclined groove on the surface of the switching circular shaft 511 is greater than the depth of the straight groove, the No. 4 spring 516 pushes the cleaning circular shaft 512 to slide upward, and the No. 3 spring 514 is compressed under the push of the straight groove of the switching circular shaft 511, and the sliding connecting shaft 515 is in the cleaning circular shaft. The shaft 512 slides inside until it pushes the sliding connecting shaft 515 back to the top of the inclined groove on the surface of the switching circular shaft 511, and the discharge barrel on the surface of the switching circular plate 314 is automatically cleaned by the cleaning mechanism 5, thereby solving the problem of low efficiency of the existing discharge barrel cleaning method. Compared with manual disassembly and cleaning, the method of automatically cleaning the discharge barrel of the switching circular plate 314 by the cleaning mechanism 5 can greatly improve the cleaning efficiency of the discharge barrel, reduce cleaning time and labor costs, and the automatic cleaning method can avoid direct contact between the operating personnel and the component compounds, thereby reducing damage to the operating personnel and pollution of the component compounds to the outside world.

[0035] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A mixing device for preparing dihydroergotamine mesylate raw materials, comprising a fixed support (1), wherein a stirring material box (2) is rotatably connected inside the fixed support (1), characterized in that: The stirring box (2) is provided with a feeding mechanism (3) for ensuring smooth feeding of each component compound, the stirring box (2) is provided with a scattering mechanism (4) for dispersing each component compound in the raw material for preparing dihydroergot mesylate, and the stirring box (2) is provided with a cleaning mechanism (5) for cleaning the lower barrel; The feeding mechanism (3) comprises a storage container (315) for storing raw materials, and the feeding mechanism (3) further comprises a switching circular plate (314) for unloading part of the compound in the storage container (315); The dispersing mechanism (4) includes a push piston (419) for pumping external gas to blow away the compound agglomerates that are stuck together, so that each component compound is dispersed in the stirring area. The dispersing mechanism (4) also includes a second slider (415) and a first slider (413) for driving the push piston (419) to slide and thus extract the external gas. The dispersing mechanism (4) also includes a second spring (4110) for pushing the push piston (419) to slide and push the gas in the device to the falling path of the compound agglomerates. The cleaning mechanism (5) comprises a cleaning circular shaft (512) for cleaning the interior of the switching circular plate (314), and the cleaning mechanism (5) further comprises a switching circular shaft (511) for adjusting the sliding state of the cleaning circular shaft (512).

2. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 1, characterized in that: The feeding mechanism (3) comprises a power gear (311), the power gear (311) being rotatably connected to the inside of the mixing material box (2), the inside of the mixing material box (2) being rotatably connected to a connecting gear (312), the power gear (311) and the connecting gear (312) being meshed with each other, the upper surface of the connecting gear (312) being fixedly connected to a connecting support rod (313), the switching circular plate (314) being fixedly connected to one end surface of the connecting support rod (313), the material storage container (315) being fixedly connected to the upper surface of the mixing material box (2), the surface of the switching circular plate (314) being fixedly connected to a material discharge barrel, the material discharge barrel on the surface of the switching circular plate (314) being connected to a material discharge port of the material storage container (315).

3. The mixing device for preparing dihydroergoline mesylate raw material according to claim 2, characterized in that: Two material storage containers (315) are provided, and the two material storage containers (315) are symmetrically arranged on the upper surface of the fixed support (1). Two material barrels are provided below the surface of the switching circular plate (314), and the two material barrels below the surface of the switching circular plate (314) are symmetrically arranged with the connecting support rod (313) as an axis.

4. The mixing device for preparing dihydroergoline mesylate raw materials according to claim 2, characterized in that: The transmission ratio between the power gear (311) and the connecting rod (313) is one to one, and the surface of the power gear (311) has only a half circle of gear blocks.

5. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 2, characterized in that: The scattering mechanism (4) comprises two bottom rotating plates (411), the two bottom rotating plates (411) are fixedly connected to the lower surface of the power gear (311), the lower surface of the bottom rotating plates (411) are fixedly connected to the pulling shaft (4111), the interior of the mixing material box (2) is slidably connected to two driving sliding frames (412), the pulling shaft (4111) is slidably connected to the interior of the driving sliding frame (412), the interior of the mixing material box (2) is slidably connected to two No. 1 sliders (413), the driving sliding frame (412) is fixedly connected to the No. 1 slider (413), and the No. 2 slider (415) is slidably connected to the interior of the mixing material box (2). The push piston (419) is fixedly connected to one end of the No. 2 slider (415), the No. 2 spring (4110) is fixedly connected to the inside of the mixing box (2), the No. 2 spring (4110) is fixedly connected to the No. 2 slider (415), the lower surface of the No. 1 slider (413) is fixedly connected to a fixed stopper (414), the inside of the No. 2 slider (415) is slidably connected to a driving slider (416), the inside of the No. 2 slider (415) is fixedly connected to a No. 1 spring (417), the No. 1 spring (417) is fixedly connected to the driving slider (416), and the inside of the mixing box (2) is fixedly connected to a switching stopper (418).

6. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 5, characterized in that: One end of the switching stopper (418) is arranged as an inclined surface, and one end of the driving slider (416) is arranged as an inclined surface, and the inclined surface of the switching stopper (418) fits the inclined surface of the driving slider (416).

7. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 5, characterized in that: The switching stopper (418) is located inside the sliding path of the driving slider (416), and the driving slider (416) is located inside the sliding path of the fixed stopper (414). The thickness of the fixed stopper (414) and the thickness of the switching stopper (418) are both half the thickness of the driving slider (416), and the fixed stopper (414) and the switching stopper (418) are not located on the same horizontal plane.

8. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 5, characterized in that: The cleaning mechanism (5) comprises a first gear (513), the first gear (513) being rotatably connected to the interior of the mixing box (2), the switching shaft (511) being rotatably connected to the interior of the mixing box (2), the first gear (513) being meshed with the power gear (311), the switching shaft (511) being fixedly connected to the first gear (513), the cleaning shaft (512) being slidably connected to the interior of the mixing box (2), the interior of the cleaning shaft (512) being slidably connected to a sliding coupling (515), and the cleaning shaft (511) being rotatably connected to the interior of the mixing box (2). 2) is fixedly connected to the inside of a No. 3 spring (514), the No. 3 spring (514) is fixedly connected to a sliding coupling (515), the surface of the switching circular shaft (511) is provided with an inclined sliding groove and a straight sliding groove, the sliding coupling (515) is slidably connected to the inside of the inclined sliding groove and the straight sliding groove on the surface of the switching circular shaft (511), the cleaning circular shaft (512) is slidably connected to the inside of the barrel under the surface of the switching circular plate (314), and the inside of the mixing box (2) is fixedly connected to a No. 4 spring (516), the No. 4 spring (516) is fixedly connected to the cleaning circular shaft (512).

9. The mixing device for preparing dihydroergotamine mesylate raw materials according to claim 8, characterized in that: The straight sliding groove on the surface of the switching circular shaft (511) is connected to the oblique sliding groove, and the depth of the oblique sliding groove on the surface of the switching circular shaft (511) is greater than the depth of the straight sliding groove on the surface of the switching circular shaft (511).

10. A method for mixing dihydroergotamine mesylate raw materials, according to the dihydroergotamine mesylate raw material preparation and mixing device according to claims 1-9, characterized in that: The steps include: S1. Raw material preparation step: the dihydroergoline mesylate raw material is prepared from four compounds, dihydroergocortin mesylate, dihydroergoline tretinoin mesylate, dihydro-α-ergocryptine mesylate and dihydro-β-ergocryptine mesylate, in a certain proportion. The discharge ports of two storage containers (315) containing different compounds are aligned and fixed with the discharge trough on the surface of the stirring box (2). The four compounds are synchronously fed into the raw material stirring area through the discharge barrel on the surface of the switching circular plate (314) in a certain proportion. S2, material mixing step: the four compounds are driven by the feeding mechanism (3) to enter the stirring area inside the stirring box (2), and the four compounds are dispersed by the scattering mechanism (4) during the falling process, and the dispersed component compounds are initially mixed, and then stirred by the stirrer inside the stirring box (2); S3, packaging and storage step: the mixed dihydroergotamine mesylate raw material is taken out from the mixing equipment, packaged or enters the next production process, and the mixing equipment is cleaned and disinfected to prevent cross contamination.

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