CIK (Cytokine Induced Killer) cell culture device with buffer protection

Abstract

The invention relates to the technical field of CIK cell culture, and discloses a CIK cell culture device with buffer protection, the CIK cell culture device comprises a culture box body, one end of the front surface of the culture box body is provided with a bin door, and two sides of the inner wall of the culture box body are symmetrically and uniformly provided with a plurality of groups of support slide rails; a culture table plate is supported by the tops of the two symmetrical groups of supporting slide rails in a sliding manner, a buffer plate is arranged at the bottom of the culture table plate, and the buffer plate is used for clamping a CIK cell culture dish at the top of the group of culture table plate under the buffer plate; according to the CIK cell culture device, a driving motor is arranged to drive a cam unit to rotate so as to drive a buffer plate to move downwards to clamp a culture dish placed at the top of a culture table plate at the bottom of the buffer plate, and meanwhile, a piston plate is driven by a supporting stand column to move downwards, so that a negative pressure state is formed in a mounting cavity and the culture box body; and the combination tightness of the incubator body and the bin door is kept.

Description

Technical Field

[0001] The invention relates to the technical field of CIK cell culture, and more particularly to a CIK cell culture device with buffer protection. Background Art

[0002] CIK cells are a type of immune cell with good anti-tumor activity and have potential application value in tumor immunotherapy. They are mainly obtained by culturing in a culture dish. The mother cells are mixed with culture fluid, placed in a culture dish, and then placed in an incubator for culture.

[0003] The existing CIK incubator usually adopts a sealed box body, and the inner support platform is usually used to support the culture dish, but lacks a buffer protection structure. When the incubator is transported, the culture dish inside it has the problem of sliding displacement. Before the culture medium inside the culture dish reaches the culture period, the CIK cells on the top layer of the culture medium will be affected by the displacement of the culture dish and covered by the culture medium liquid, which will cause the CIK cell division to be damaged, prolong the CIK cell culture cycle, and even cause the CIK cell culture to be interrupted. At the same time, during the transportation process, it is easy to cause gas leakage inside the culture box, thereby polluting the culture environment of CIK cells, so it is necessary to optimize the structure of the existing incubator. Summary of the invention

[0004] The present invention provides a CIK cell culture device with buffer protection, which solves the technical problem in the related art that a CIK cell culture box is prone to slide and overturn during transportation.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] A CIK cell culture device with buffer protection comprises a culture box, a door is arranged at one end of the front of the culture box, a plurality of groups of support rails are symmetrically arranged on both sides of the inner wall of the culture box, a culture table is slidably supported on the top of two symmetrical groups of support rails, a buffer plate is arranged at the bottom of the culture table, and the buffer plate is used to clamp the CIK cell culture dish on the top of a group of culture tables directly below;

[0007] Both sides of the culture box are provided with installation cavities, and the interior of the installation cavity is provided with a positioning buffer drive mechanism, one end of the positioning buffer drive mechanism extends to the interior of the culture box and is adapted to the buffer plate;

[0008] Linkage mechanisms that are transmission-connected to the positioning buffer drive mechanism are symmetrically arranged on both sides of the top of the culture box body. A driving motor that is transmission-connected to the linkage mechanism is arranged in the middle of the top of the culture box body. A sealing cover is arranged on the outer side of the linkage mechanism. The driving motor provides a driving force to drive the linkage mechanism to link with the positioning buffer drive mechanism to move, thereby driving the buffer plate to move downward and forming a negative pressure inside the culture box body and the installation cavity.

[0009] As a further optimization scheme of the present invention, the linkage mechanism includes a cam unit arranged in the middle of the top of the incubator body, the top of the cam unit is synchronously connected to the output end of the driving motor, both ends of the top of the cam unit are hinged with a first hinged rod, the other end of the first hinged rod is hinged with a first hinged slide, the other end of the first hinged slide is symmetrically hinged with two groups of second hinged rods, the other ends of the second hinged rods are each provided with a second hinged slide, and the ends of the two groups of second hinged slides close to each other are both hinged with a third hinged rod.

[0010] As a further optimization scheme of the present invention, the top of the culture box body is provided with a first slide groove that is slidably adapted to the first articulated slide, and the top of the culture box body is provided with a second slide groove that is slidably adapted to the second articulated slide, the first articulated rod, the first articulated slide, and the second articulated rod are all transverse connection structures, and the third articulated rod is a longitudinal connection structure.

[0011] As a further optimization scheme of the present invention, when the cam unit rotates to push the first articulated rod to displace, it further drives the first articulated slide to displace horizontally inside the first slide groove, and further drives the second articulated rod to push the second articulated slide to displace horizontally inside the second slide groove.

[0012] As a further optimization scheme of the present invention, the positioning and buffering drive mechanism includes a piston plate arranged at the bottom of the installation cavity, the middle part of the top of the piston plate is fastened with a support column extending to the top of the incubator body, a sealing ring is arranged between the edge position of the piston plate and the inner wall of the installation cavity, vertical support rods are symmetrically arranged at the top of the piston plate on both sides of the support column, and several groups of support connecting rods fastened to the vertical support rods are evenly distributed on both sides of the support column.

[0013] As a further optimization scheme of the present invention, the other end of the third hinged rod is hinged to the top of the supporting column respectively. When the second hinged slide seat is displaced longitudinally and horizontally, the third hinged rod is driven to pull the supporting column to move downward, thereby driving the piston plate to move downward.

[0014] As a further optimization scheme of the present invention, a plurality of groups of sliding cross bars are evenly distributed on one side of the vertical support rod located inside the installation cavity, penetrating the vertical support rod and extending to the inside of the incubator body; a first support plug is provided at one end of the sliding cross bar near the port of the incubator body, a second support plug is provided at one end of the sliding cross bar near the inside of the incubator body, and a synchronous connecting rod is provided between the first support plug and the second support plug.

[0015] As a further optimization scheme of the present invention, the bottom of the culture platform is evenly provided with a first spring, the bottom of the first spring jointly supports a buffer plate, and the first guide wedge block and the second guide wedge block are respectively provided on both sides of the buffer plate, the first guide wedge block is close to the port position of the culture box body, and the second guide wedge block is close to the inner side position of the culture box body, the first guide wedge block corresponds to the first support block, and the second guide wedge block corresponds to the second support block.

[0016] As a further optimization scheme of the present invention, a support base is provided at the top of the sliding cross bar at one end on the inner side of the installation cavity, and a second spring is provided between the support base and the vertical support bar. The distance between the second support block and the inner wall of the adjacent culture box body is greater than the distance between the first support block and the inner wall of the adjacent culture box body. At the same time, the distance between the second guide wedge block and the buffer plate is less than the distance between the first guide wedge block and the buffer plate.

[0017] As a further optimization scheme of the present invention, a buffer plate is not provided at the bottom of a group of culture plates located at the bottom end of the culture box body, a buffer plate is provided at the top position inside the culture box body, and a first buffer pad and a second buffer pad corresponding to the culture plates are provided on the inner side of the door and one end of the back side of the culture box body, and an exhaust hole connected to the outside is provided at the bottom of the installation cavity.

[0018] The beneficial effects of the present invention are as follows: the present invention is provided with a driving motor to drive the cam unit to rotate, thereby driving the supporting column to move downward as a whole, and the displacement of the supporting column drives the vertical supporting rod to follow the displacement, thereby driving the buffer plate supported by the first supporting block and the second supporting block to move downward, and the culture dish placed on the top of the bottom culture table of the buffer plate is clamped by the downward displacement of the buffer plate. At the same time, the piston plate is driven to move downward by the supporting column, so that the space inside the installation cavity and the culture box body is increased to form a negative pressure state, and the external atmospheric pressure acts on the door to maintain the tightness of the combination of the culture box body and the door, thereby realizing the buffering and protection functions of the CIK cell culture dish. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a three-dimensional structural schematic diagram of the present invention;

[0020] Figure 2 It is an enlarged schematic diagram of the internal structure of the culture box in the present invention;

[0021] Figure 3 It is an enlarged schematic diagram of the connection structure of the linkage mechanism in the present invention;

[0022] Figure 4 It is an enlarged cross-sectional view of the internal connection structure of the culture box body in the present invention;

[0023] Figure 5 yes Figure 4 A schematic diagram of the structure at A;

[0024] Figure 6 It is an enlarged schematic diagram of the connection structure between the buffer plate and the positioning buffer drive mechanism in the present invention;

[0025] Figure 7 It is an enlarged cross-sectional view of the internal structure of the installation cavity in the present invention;

[0026] Figure 8 It is an enlarged schematic diagram of the connection structure between the culture platform and the buffer plate in the present invention;

[0027] Fig. 9 It is an enlarged cross-sectional view of the internal structure of the buffer plate in the present invention;

[0028] Fig.10 It is an enlarged schematic diagram of the connection structure at the positioning buffer drive mechanism in the present invention.

[0029] In the figure:

[0030] 1. Incubator; 2. Drive motor; 3. Door; 4. First buffer pad; 5. Incubation table; 6. Buffer plate; 7. Support rail; 8. Second buffer pad; 9. Installation cavity; 10. First spring;

[0031] 11. first guide wedge; 12. first slide groove; 13. second slide groove; 14. second guide wedge; 15. exhaust hole;

[0032] 100, linkage mechanism; 101, cam unit; 102, first articulated rod; 103, first articulated slide; 104, second articulated rod; 105, third articulated rod; 106, second articulated slide;

[0033] 200, positioning buffer drive mechanism; 201, support base; 202, vertical support rod; 203, sliding cross bar; 204, second spring; 205, support connecting rod; 206, support column; 207, piston plate; 208, first support plug block; 209, synchronous connecting rod; 210, second support plug block. DETAILED DESCRIPTION

[0034] The subject matter described herein will now be discussed with reference to example embodiments. It should be understood that the discussion of these embodiments is only to enable those skilled in the art to better understand and implement the subject matter described herein, and the functions and arrangements of the elements discussed may be changed without departing from the scope of protection of the present specification. Various examples may omit, replace or add various processes or components as needed. In addition, the features described relative to some examples may also be combined in other examples.

[0035] Example 1

[0036] like Figure 1 and Figure 2 As shown, a CIK cell culture device with buffer protection comprises a culture box 1, a compartment door 3 is arranged at one end of the front of the culture box 1, a plurality of groups of support rails 7 are symmetrically arranged on both sides of the inner wall of the culture box 1, a culture table 5 is slidably supported on the top of two symmetrical groups of support rails 7, a buffer plate 6 is arranged at the bottom of the culture table 5, and the buffer plate 6 is used to clamp the CIK cell culture dish on the top of a group of culture tables 5 directly below;

[0037] like Figure 2 and Figure 4 As shown, both sides of the culture box 1 are provided with installation cavities 9, and the interior of the installation cavity 9 is provided with a positioning buffer drive mechanism 200, one end of the positioning buffer drive mechanism 200 extends to the interior of the culture box 1 and is adapted to the buffer plate 6, and the bottom of a group of culture plates 5 located at the bottom end of the culture box 1 is not provided with a buffer plate 6, and a buffer plate 6 is provided at the top position of the culture box 1, and the inner side of the compartment door 3 and the back end of the interior of the culture box 1 are provided with a first buffer pad 4 and a second buffer pad 8 corresponding to the culture plate 5, and the bottom of the interior of the installation cavity 9 is provided with an exhaust through hole 15 that is interconnected with the outside;

[0038] like Figure 2 , Figure 3 and Figure 7As shown, linkage mechanisms 100 that are transmission-connected to the positioning buffer driving mechanism 200 are symmetrically arranged on both sides of the top of the culture box body 1, a driving motor 2 that is transmission-connected to the linkage mechanism 100 is arranged in the middle of the top of the culture box body 1, and a sealing cover is arranged on the outer side of the linkage mechanism 100. The linkage mechanism 100 includes a cam unit 101 arranged in the middle of the top of the culture box body 1, the top of the cam unit 101 is synchronously connected to the output end of the driving motor 2, both ends of the top of the cam unit 101 are hinged with a first hinge rod 102, the other end of the first hinge rod 102 is hinged with a first hinge slide 103, the other end of the first hinge slide 103 is symmetrically hinged with two groups of second hinge rods 104, and the other ends of the second hinge rods 104 are all provided with second hinge slides. The first hinged slide 103 is connected to the second hinged slide 106 by the third hinged rod 105. The top of the culture box 1 is provided with a first slide groove 12 slidably adapted to the first hinged slide 103. The top of the culture box 1 is provided with a second slide groove 13 slidably adapted to the second hinged slide 106. The first hinged rod 102, the first hinged slide 103 and the second hinged rod 104 are all transverse connection structures. The third hinged rod 105 is a longitudinal connection structure. When the cam unit 101 rotates to push the first hinged rod 102 to move, the first hinged slide 103 is driven to move horizontally in the first slide groove 12, and the second hinged rod 104 is driven to push the second hinged slide 106 to move horizontally in the second slide groove 13.

[0039] The driving motor 2 provides driving force to drive the linkage mechanism 100 to link the positioning buffer driving mechanism 200 to move, thereby driving the buffer plate 6 to move downward and forming negative pressure inside the culture box 1 and the installation cavity 9;

[0040] like Figures 4 to 6 , Fig.10As shown, the positioning buffer drive mechanism 200 includes a piston plate 207 arranged at the bottom of the installation cavity 9, and the middle part of the top of the piston plate 207 is fastened with a support column 206 extending to the top of the culture box body 1, and a sealing ring is arranged between the edge position of the piston plate 207 and the inner wall of the installation cavity 9, and the top of the piston plate 207 is symmetrically provided with vertical support rods 202 at the positions on both sides of the support column 206, and a plurality of groups of support connecting rods 205 fastened to the vertical support rods 202 are evenly distributed on both sides of the support column 206, and the other ends of the third hinged rods 105 are respectively hinged to the tops of the support columns 206. When the second hinged slide 106 is longitudinally displaced horizontally, the third hinged rod 105 is driven 05 pulls the support column 206 downward, thereby driving the piston plate 207 to move downward, and the vertical support rod 202 is evenly distributed on one side of the installation cavity 9, and a plurality of sliding cross bars 203 that penetrate the vertical support rod 202 and extend to the inside of the culture box 1 are evenly distributed, and a first support plug 208 is arranged at one end of the sliding cross bar 203 near the port of the culture box 1, and a second support plug 210 is arranged at one end of the sliding cross bar 203 near the inside of the culture box 1, and a synchronous connecting rod 209 is commonly arranged between the first support plug 208 and the second support plug 210, and the bottom of the culture table 5 is evenly arranged with a first spring 10, and the bottom of the first spring 10 commonly supports a buffer plate 6;

[0041] like Figures 8 to 10 As shown, a first guide wedge 11 and a second guide wedge 14 are respectively provided on both sides of the buffer plate 6, the first guide wedge 11 is located close to the port position of the culture box body 1, and the second guide wedge 14 is located close to the inner side position of the culture box body 1, the first guide wedge 11 corresponds to the first support plug 208, and the second guide wedge 14 corresponds to the second support plug 210, and a support base 201 is provided on the top of the sliding cross bar 203 located at one end of the inner side of the installation cavity 9, and a second spring 204 is jointly provided between the support base 201 and the vertical support rod 202, and the distance between the second support plug 210 and the inner wall of the adjacent culture box body 1 is greater than the distance between the first support plug 208 and the inner wall of the adjacent culture box body 1, and at the same time, the distance that the second guide wedge 14 protrudes from the buffer plate 6 is less than the distance that the first guide wedge 11 protrudes from the buffer plate 6.

[0042] The use process of the CIK cell culture device with buffer protection proposed in this embodiment is as follows: when the device is in use, a culture dish containing culture medium is placed on the top of the culture platform 5, and then the door 3 is closed, so that a relatively sealed environment is formed inside the culture box 1. At this time, the drive motor 2 is started to drive the cam unit 101 to rotate, and then the cam unit 101 drives the first hinge rod 102 to move, and the first hinge rod 102 pushes the first hinge slide 103 to slide inside the first slide groove 12;

[0043] The first hinged slide 103 pushes the second hinged rod 104 to move, thereby driving the two groups of second hinged slides 106 to move away from each other, so that the second hinged slide 106 pulls the support column 206 connected to the third hinged rod 105 to move downward, and the piston plate 207 is driven to move downward by the downward displacement of the support column 206, so that the sealed volume of the space inside the installation cavity 9 and the culture box 1 becomes larger, thereby forming a negative pressure state in the area, and under the action of the external atmospheric pressure, the door 3 and the culture box 1 are more closely fitted, thereby avoiding the separation of the door 3 and the culture box 1 during transportation, and causing the problem of the culture environment being polluted;

[0044] During the downward displacement of the support column 206, the vertical support rod 202 is driven to move downward by the support connecting rod 205, and the first support plug 208 and the second support plug 210 connected to the sliding cross bar 203 are driven to move downward synchronously by the vertical support rod 202, so that the buffer plate 6 moves downward and forms a clamping state with the culture platform 5 directly below it, and the culture dish on the top of the culture platform 5 is clamped up and down, thereby maintaining the stability of the position structure of the culture dish and preventing it from tipping over during transportation;

[0045] Furthermore, when the door 3 needs to be opened, the driving motor 2 is started to run in the reverse direction, thereby driving the various components to move in the reverse direction, so that the buffer plate 6 releases the clamping state of the culture dish, and at the same time, the piston plate 207 moves up synchronously, so that the volume of the sealed space formed inside the culture box 1 and the installation cavity 9 returns to the normal state, and then the door 3 is opened;

[0046] In the process of pulling out the culture platform 5, the buffer plate 6 at the bottom of the first spring 10 is driven to follow the displacement by the culture platform 5, and at this time, the first guide wedge 11 and the second guide wedge 14 on both sides of the buffer plate 6 are respectively disengaged from the first support plug 208 and the second support plug 210, so that the culture platform 5 can be normally displaced;

[0047] When the culture platform 5 is pushed into the interior of the culture box 1, the second guide wedge 14 is first engaged with the second support plug 210, and then the second support plug 210 is guided by the second guide wedge 14, so that the second support plug 210 is displaced toward the inside of the second guide wedge 14. When the second support plug 210 is displaced, it drives the first support plug 208 connected to the synchronization connecting rod 209 to be displaced synchronously, so that the first support plug 208 is engaged with the first guide wedge 11, and then the first support plug 208 is displaced toward the inside of the first guide wedge 11 under the guidance of the first guide wedge 11, so that the connection between the first support plug 208 and the second support plug 210 on the buffer plate 6 is realized. In the process of synchronous displacement of the first support plug 208 and the second support plug 210, the support base 201 at the top of the sliding cross bar 203 is driven to compress the second spring 204, so that when the culture platform 5 is pulled out, the rebound force of the second spring 204 can drive the first support plug 208 and the second support plug 210 to reset.

[0048] The specific implementation methods of this embodiment are described above, but this embodiment is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Ordinary technicians in this field can also make many forms inspired by this embodiment, all of which are within the protection of this embodiment.

Claims

1. A CIK cell culture device with buffer protection, characterized in that: The invention comprises a culture box (1), wherein a door (3) is arranged at one end of the front side of the culture box (1), and a plurality of groups of support rails (7) are symmetrically arranged on both sides of the inner wall of the culture box (1), and a culture platform (5) is slidably supported on the tops of the two symmetrical groups of support rails (7), and a buffer plate (6) is arranged at the bottom of the culture platform (5), and the buffer plate (6) is used to clamp the CIK cell culture dish on the top of a group of culture platforms (5) directly below; Both sides of the culture box (1) are provided with installation cavities (9), and a positioning buffer drive mechanism (200) is provided inside the installation cavity (9). One end of the positioning buffer drive mechanism (200) extends into the interior of the culture box (1) and is adapted to the buffer plate (6); Linkage mechanisms (100) are symmetrically arranged on both sides of the top of the culture box (1) and are transmission-connected to the positioning buffer drive mechanism (200); a drive motor (2) is transmission-connected to the linkage mechanism (100) in the middle of the top of the culture box (1); a sealing cover is arranged on the outside of the linkage mechanism (100); the drive motor (2) provides a driving force to drive the linkage mechanism (100) to move in conjunction with the positioning buffer drive mechanism (200), thereby driving the buffer plate (6) to move downward and simultaneously forming a negative pressure inside the culture box (1) and the installation cavity (9).

2. A CIK cell culture device with buffer protection according to claim 1, characterized in that: The linkage mechanism (100) comprises a cam unit (101) arranged at the middle of the top of the culture box (1); the top of the cam unit (101) is synchronously connected to the output end of the drive motor (2); both ends of the top of the cam unit (101) are hinged with a first hinged rod (102); the other end of the first hinged rod (102) is hinged with a first hinged slide (103); the other end of the first hinged slide (103) is symmetrically hinged with two groups of second hinged rods (104); the other ends of the second hinged rods (104) are each provided with a second hinged slide (106); and the ends of the two groups of the second hinged slides (106) that are close to each other are each hinged with a third hinged rod (105).

3. A CIK cell culture device with buffer protection according to claim 2, characterized in that: The top of the culture box body (1) is provided with a first slide groove (12) slidably matched with the first hinged slide seat (103), and the top of the culture box body (1) is provided with a second slide groove (13) slidably matched with the second hinged slide seat (106). The first hinge rod (102), the first hinged slide seat (103), and the second hinge rod (104) are all transverse connection structures, and the third hinge rod (105) is a longitudinal connection structure.

4. The CIK cell culture device with buffer protection according to claim 3, characterized in that: When the cam unit (101) rotates to push the first hinged rod (102) to move, it further drives the first hinged slide (103) to move horizontally inside the first slide groove (12), and further drives the second hinged rod (104) to push the second hinged slide (106) to move horizontally inside the second slide groove (13).

5. The CIK cell culture device with buffer protection according to claim 1, characterized in that: The positioning buffer drive mechanism (200) comprises a piston plate (207) arranged at the bottom of the installation cavity (9); a support column (206) extending to the top of the culture box (1) is fastened to the middle of the top of the piston plate (207); a sealing ring is arranged between the edge of the piston plate (207) and the inner wall of the installation cavity (9); vertical support rods (202) are symmetrically arranged at the top of the piston plate (207) at positions on both sides of the support column (206); and a plurality of groups of support connecting rods (205) fastened to the vertical support rods (202) are evenly distributed on both sides of the support column (206).

6. A CIK cell culture device with buffer protection according to claim 2 or 5, characterized in that: The other end of the third hinged rod (105) is hinged to the top of the supporting column (206). When the second hinged slide (106) moves horizontally in the longitudinal direction, the third hinged rod (105) is driven to pull the supporting column (206) to move downward, thereby driving the piston plate (207) to move downward.

7. The CIK cell culture device with buffer protection according to claim 5, characterized in that: A plurality of groups of sliding cross bars (203) are evenly distributed on one side of the vertical support bar (202) located inside the installation cavity (9), and penetrate the vertical support bar (202) and extend into the interior of the culture box (1); a first support plug (208) is arranged at one end of the sliding cross bar (203) near the port of the culture box (1); a second support plug (210) is arranged at one end of the sliding cross bar (203) near the interior of the culture box (1); and a synchronous connecting rod (209) is arranged between the first support plug (208) and the second support plug (210).

8. The CIK cell culture device with buffer protection according to claim 7, characterized in that: The bottom of the culture platform (5) is evenly provided with a first spring (10), and the bottom of the first spring (10) jointly supports a buffer plate (6). The two sides of the buffer plate (6) are respectively provided with a first guide wedge (11) and a second guide wedge (14), the first guide wedge (11) is close to the port position of the culture box (1), and the second guide wedge (14) is close to the inner side position of the culture box (1), the first guide wedge (11) corresponds to the first support plug (208), and the second guide wedge (14) corresponds to the second support plug (210).

9. The CIK cell culture device with buffer protection according to claim 8, characterized in that: A support base (201) is provided at the top of one end of the sliding cross bar (203) located inside the installation cavity (9); a second spring (204) is provided between the support base (201) and the vertical support bar (202); the distance between the second support plug (210) and the inner wall of the adjacent culture box (1) is greater than the distance between the first support plug (208) and the inner wall of the adjacent culture box (1); and at the same time, the distance between the second guide wedge (14) and the buffer plate (6) is less than the distance between the first guide wedge (11) and the buffer plate (6).

10. The CIK cell culture device with buffer protection according to claim 1, characterized in that: A buffer plate (6) is not provided at the bottom of a group of culture plates (5) located at the bottom end of the culture box (1), but a buffer plate (6) is provided at the top of the culture box (1), and a first buffer pad (4) and a second buffer pad (8) corresponding to the culture plates (5) are provided on the inner side of the door (3) and the back end of the culture box (1), and an exhaust hole (15) communicating with the outside is provided at the bottom of the installation cavity (9).

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