Head-mounted optical out-of-focus myopia induction device

Abstract

The invention discloses a head-mounted optical out-of-focus myopia induction device, and relates to the technical field of myopia induction devices, and the head-mounted optical out-of-focus myopia induction device comprises a head fixing frame, a spectacle frame and out-of-focus induction lenses; a fixing hole is formed in the head fixing frame; the spectacle frame comprises an adjusting frame and a lens mounting seat, the tail end of the adjusting frame is bent towards the inner lower side, and the lens mounting seat and the bent tail end of the lens mounting seat are integrally formed and extend towards the outer side; the adjusting frame is detachably connected with the head fixing frame; the out-of-focus induction lens is pasted on the lens installation seat through glue. The device is convenient to mount, dismount and clean, and the risk of infection of skin and cornea around eyes is reduced; a relatively high degree can be induced in a relatively short time, and high efficiency is reflected; the whole device can be manufactured in batches in a standard mode, repeatability and standard performance are guaranteed, and the price is low.

Description

Technical Field

[0001] The present invention relates to the technical field of myopia inducing devices, and in particular to a head-mounted optical defocus myopia inducing device. Background Art

[0002] As the incidence of myopia continues to rise worldwide, research on its pathogenesis and prevention and control strategies has received increasing attention. Mice, as a commonly used experimental animal model, play an important role in visual development and myopia research. However, there is currently a lack of optical devices designed for the characteristics of mice that can effectively induce myopia on the market. Therefore, it is particularly important to develop a head-mounted optical defocus myopia induction device for mice that is easy to operate and has significant effects. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a head-mounted optical defocus myopia inducing device for mice. The device has a compact structure, is comfortable to wear, and is easy to adjust. It can accurately control the defocus amount and effectively induce myopia reactions in mice, providing strong support for the study of the pathogenesis of myopia and the development of prevention and control strategies.

[0004] In order to solve the above technical problems, the technical solution provided by the present invention is: a head-mounted optical defocus myopia inducing device, comprising a head fixing frame, a glasses frame and a defocus inducing lens;

[0005] The head fixing frame is provided with a fixing hole;

[0006] The frame includes an adjustment frame and a lens mounting seat, the end of the adjustment frame is bent inward and downward, and the lens mounting seat and its bent end are integrally formed and extend outward; the adjustment frame is detachably connected to the head fixing frame;

[0007] The defocus inducing lens is adhered to the lens mounting seat by glue.

[0008] Furthermore, the adjustment frame is provided with an adjustment notch, and a plurality of fixing holes are evenly arranged on the head fixing frame, and the adjustment notch corresponds to the position of the fixing holes.

[0009] Furthermore, the adjustment frame and the head fixing frame are fixedly connected by bolts and nuts. After the bolts pass through the fixing holes and the adjustment notches, they cooperate with the nuts to press and fix the adjustment frame and the head fixing frame.

[0010] Furthermore, it also includes a collar, which is sleeved on the outside of the frame and is trumpet-shaped.

[0011] Furthermore, the defocus inducing lens is adhered and fixed to the lens mounting seat by cyanoacrylate quick-drying glue.

[0012] Compared with the prior art, the advantages of the present invention are: the present invention is easy to install, disassemble and clean, reducing the risk of infection of the skin around the eyes and the cornea; it can induce a higher degree in a shorter time, reflecting high efficiency; the entire device can be mass-produced in a standard manner, ensuring repeatability and standardization, and the price is low. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the structure of a head-mounted optical defocus myopia inducing device of the present invention. Figure 1 .

[0014] Figure 2 This is a schematic diagram of the structure of a head-mounted optical defocus myopia inducing device of the present invention. Figure 2 .

[0015] Figure 3 It is a front view of a head-mounted optical defocus myopia inducing device of the present invention.

[0016] Figure 4 The present invention is a top view of a head-mounted optical defocus myopia inducing device.

[0017] Figure 5 This is a reference diagram of the usage status of a head-mounted optical defocus myopia inducing device of the present invention.

[0018] As shown in the figure: 1. Head fixing frame, 2. Mirror frame, 3. Defocus inducing lens, 4. Fixing hole, 5. Adjustment frame, 6. Lens mounting seat, 7. Adjustment slot, 8. Bolt, 9. Nut, 10. Collar. DETAILED DESCRIPTION

[0019] In the description of the present invention, it is necessary to understand that the orientations or positional relationships indicated by terms such as “upper”, “lower”, “front”, “back”, “left”, “right”, “inside”, “outside”, “vertical” and “circumferential” are based on the orientations or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0020] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0021] The head-mounted optical defocus myopia inducing device of the present invention is further described in detail below in conjunction with the accompanying drawings.

[0022] Combined with Figure 1-5 , the present invention is introduced in detail.

[0023] A head-mounted optical defocus myopia inducing device mainly comprises three parts: a head fixing frame 1, a glasses frame 2 and a defocus inducing lens 3.

[0024] The head fixing frame 1 is provided with fixing holes 4 for detachable connection with the mirror frame 2. Several fixing holes 4 are evenly arranged so as to be adjusted according to the actual size of the mouse head.

[0025] The frame 2 is composed of an adjustment frame 5 and a lens mounting seat 6. The end of the adjustment frame 5 is bent inward and downward to adapt to the facial contour of the mouse; the lens mounting seat 6 is integrally formed with the bent end of the adjustment frame 5 and extends outward to install the defocus inducing lens 3. The adjustment frame 5 is provided with an adjustment notch 7, which corresponds to the position of the fixing hole 4 on the head fixing frame 1, so that the frame 2 and the head fixing frame 1 can be fastened together by the combination of bolts 8 and nuts 9.

[0026] The defocus inducing lens 3 is glued to the lens mounting seat 6 by glue (preferably cyanoacrylate quick-drying glue). To enhance the protection of the lens, a collar 10 is put on the neck of the mouse. The collar 10 is trumpet-shaped and located at the neck position, does not block the eyes, does not affect the visual effect, and can prevent the claws from scratching the lens.

[0027] The specific implementation process of the head-mounted optical defocus myopia inducing device of the present invention is as follows:

[0028] The head fixing frame 1 uses a 2 cm nylon rod, and punches a hole at one end about 3-4 mm away from the edge. The size of the hole is suitable for an M1.4 bolt 8, and the bolt 8 is combined with the nylon rod.

[0029] Installation specific operations:

[0030] 1) Anesthesia of mice: P21-aged mice weighing more than 8 g (refractive state tends to be stable, without extreme myopia or extreme hyperopia) were selected and anesthetized with 0.2 ml / 10 g of 1.2% Avertin.

[0031] 2) Cut the mouth, cut a window of about 0.8cm2 in the middle of the line connecting the midpoints of the two ears to the midpoints of the eyes, clean the connective tissue, blood and hair, and after drying, fix the nylon rod on the mouse head with oral special adhesive light-curing resin, put the mouse in the observation box, and wait for it to wake up. It is not recommended to fix frame glasses on the screws on the nylon rod within 24 hours.

[0032] 3) After waiting for 24 hours to completely dry, hold the nylon rod, place the mouse on the operating table, fix the frame glasses, and adjust the angle.

[0033] 4) Put a collar 10 on the mouse. The collar 10 is made of a highly transparent PVC plastic plate, 0.25 mm thick, with an inner ring size of 1.7 cm and a side width of 1.2 cm. It prevents the mouse from scratching, reduces the weight of the mouse frame, protects the lens from being scratched by the mouse, and reduces the possibility of the mouse frame falling off. At the same time, please wear the collar 10 when the mouse is fully awake, and adjust the tightness to ensure that it does not fall off and can play a role.

[0034] 5) Observe the behavior of the mice and maintain a cleaning frequency of twice a week to prevent bedding and food debris from entering the gap between the glasses and the eyes, affecting the clarity of the lenses and causing errors in the experimental results. This frequency also allows the mice to have time to comb the hair on their faces and around their eyes to prevent complications from other eye diseases.

[0035] The present invention is suitable for constructing a high myopia model of an animal (C57BL6). Compared with existing devices, this head-mounted optical defocus myopia induction device for efficiently constructing a high myopia animal model has the following advantages:

[0036] It can be loaded and unloaded for cleaning, reducing the risk of infection of the skin and cornea around the eyes; it can induce a higher degree in a shorter period of time, reflecting high efficiency; the entire device can be mass-produced in a standardized manner, ensuring repeatability and standardization; and it is inexpensive.

[0037] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A head-mounted optical defocus myopia inducing device, characterized in that: It comprises a head fixing frame (1), a mirror frame (2) and a defocus inducing lens (3); The head fixing frame (1) is provided with a fixing hole (4); The frame (2) comprises an adjustment frame (5) and a lens mounting seat (6); the end of the adjustment frame (5) is bent inwardly and downwardly; the lens mounting seat (6) and its bent end are integrally formed and extend outwardly; the adjustment frame (5) is detachably connected to the head fixing frame (1); The defocus inducing lens (3) is adhered to the lens mounting seat (6) by glue.

2. A head-mounted optical defocus myopia inducing device according to claim 1, characterized in that: The adjustment frame (5) is provided with an adjustment notch (7), and a plurality of fixing holes (4) are evenly arranged on the head fixing frame (1), and the adjustment notch (7) corresponds to the position of the fixing holes (4).

3. A head-mounted optical defocus myopia inducing device according to claim 2, characterized in that: The adjustment frame (5) and the head fixing frame (1) are fixedly connected by means of bolts (8) and nuts (9); the bolts (8) pass through the fixing holes (4) and the adjustment notches (7) and then cooperate with the nuts (9) to press and fix the adjustment frame (5) and the head fixing frame (1).

4. A head-mounted optical defocus myopia inducing device according to claim 3, characterized in that: It also comprises a collar (10), wherein the collar (10) is sleeved on the outside of the frame (2), and the collar (10) is in a trumpet shape.

5. A head-mounted optical defocus myopia inducing device according to claim 4, characterized in that: The defocus inducing lens (3) is adhered and fixed to the lens mounting seat (6) by using cyanoacrylate quick-drying glue.

Images