Multi-channel stimulation chip and multi-channel stimulation system

Abstract

A multichannel stimulation chip comprises a reconfigurable stimulation driving array, the reconfigurable stimulation driving array comprises a plurality of mutually independent constant-current stimulation units, each constant-current stimulation unit serves as a stimulation channel, and any two constant-current stimulation units can be freely paired to form a bipolar stimulation pair; the current generation module is used for generating stimulation reference current required by each constant-current stimulation unit; the control module is used for receiving an external digital configuration instruction, selecting at least two constant-current stimulation units to form a bipolar stimulation pair based on the external control instruction, and controlling the bipolar stimulation pair to generate a bipolar biphase current stimulation signal based on the stimulation reference current; and the high-voltage production and power management module is used for converting the voltage source into a power supply voltage source and a bias voltage. According to the multichannel stimulation chip, space programming can be carried out according to an external digital configuration instruction to realize free pairing of the constant-current stimulation units, abundant bipolar stimulation pairing combinations are formed, and diversified stimulation requirements are met.

Description

Technical Field

[0001] The present application relates to the field of chips and electronic circuits, and in particular to a multi-channel stimulation chip and a multi-channel stimulation system. Background Art

[0002] Neuroelectric stimulation is a technique that affects the function of the nervous system by stimulating nerve tissue with an electric current. Electric stimulation can be used for basic research in the field of neuroscience and is also widely used in the treatment and rehabilitation of neurological diseases. In neuroelectric stimulation, electric current is delivered to the nerve tissue through electrodes to activate or inhibit the activity of neurons. This stimulation can act directly on the nerve tissue or by stimulating external nerves, such as nerve endings on the skin or nerves on the scalp. In clinical applications, electric stimulation is widely used to treat various neurological diseases, such as Parkinson's disease, depression, epilepsy and neuralgia. It can relieve symptoms and improve the quality of life of patients by regulating the activity of the nervous system. In addition, electric stimulation is also used in neurorehabilitation to help patients regain motor function, improve perception and promote nerve regeneration.

[0003] Traditional multi-channel neurostimulation devices use fixed multiple pairs of bipolar stimulation pairs to stimulate multiple nervous system locations. The bipolar stimulation pairs are fixed, the anode electrodes and cathode electrodes cannot be freely paired, and lack spatial programmability. Summary of the invention

[0004] In view of the above-mentioned shortcomings of the prior art, the purpose of the present application is to provide a multi-channel stimulation chip and a multi-channel stimulation system to solve the problem that the anode electrodes and cathode electrodes of the multi-channel neural stimulation equipment in the prior art cannot be freely paired and lack spatial programmability.

[0005] To achieve the above objectives and other related objectives, the present application provides a multi-channel stimulation chip, comprising:

[0006] A reconfigurable stimulation drive array includes a plurality of independent constant current stimulation units, each of which serves as a stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair;

[0007] A current generating module, used for generating a stimulation reference current required by each of the constant current stimulation units;

[0008] A control module, configured to receive an external digital configuration instruction, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instruction, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current;

[0009] High voltage generation and power management modules that convert voltage sources into supply voltage supplies.

[0010] In an optional embodiment of the present application, the current generating module adopts a multi-bit DAC digital-to-analog converter.

[0011] In an optional embodiment of the present application, the constant current stimulation unit includes a pull-up path having a high-voltage side current source and a pull-down path having a low-voltage side current source; one end of the pull-up path is connected to the power supply voltage power supply, and the other end is connected to one end of the pull-down path, the other end of the pull-down path is grounded or connected to a negative power supply, and the connection point between the pull-up path and the pull-down path is connected to the stimulation electrode.

[0012] In an optional embodiment of the present application, the constant current stimulation unit has a first operation mode and a second operation mode. In the first operation mode and the second operation mode, the opening order of the pull-up path and the pull-down path of the constant current stimulation unit is opposite.

[0013] In an optional embodiment of the present application, one of the constant current stimulation units constituting the bipolar stimulation pair operates in a first operation mode, and the other constant current stimulation unit operates in a second operation mode.

[0014] In an optional embodiment of the present application, the constant current stimulation unit includes a high-voltage side current source, a low-voltage side current source and a transistor circuit;

[0015] The transistor circuit includes a first transistor and a second transistor;

[0016] The source of the first transistor is connected to a high-voltage side current source, the gate of the first transistor is connected to a high-voltage side control signal, the drain of the first transistor is connected to a drain of the second transistor, the source of the second transistor is connected to a low-voltage side current source, and the gate of the second transistor is connected to a low-voltage side control signal.

[0017] In an optional embodiment of the present application, the constant current stimulation unit also includes a third transistor, the gate of the third transistor is connected to the charge balance control signal, the source of the third transistor is grounded, and the drain of the third transistor is connected to the drain of the first transistor and the drain of the second transistor.

[0018] In an optional embodiment of the present application, the constant current stimulation unit includes a high-voltage side current source, a low-voltage side current source and a transistor circuit; the transistor circuit includes first to eighth transistors;

[0019] The source of the first transistor is connected to a high-side current source, the gate of the first transistor is connected to a high-side control signal, the drain of the first transistor is connected to the source of the eighth transistor, the gate of the eighth transistor is connected to a bias voltage and the drain of the ninth transistor, the drain of the eighth transistor is connected to the gate of the ninth transistor and the source of the fourth transistor, the source of the ninth transistor, the gate of the fourth transistor and the gate of the fifth transistor are connected to the source of the sixth transistor, the drain of the fourth transistor and the drain of the fifth transistor are connected to a stimulation electrode, the source of the fifth transistor is connected to the gate of the sixth transistor and the drain of the seventh transistor, the drain of the sixth transistor and the gate of the seventh transistor are connected to a voltage source, the source of the seventh transistor is connected to the drain of the second transistor, the source of the second transistor is connected to a low-voltage side current source, and the gate of the second transistor is connected to a low-voltage side control signal.

[0020] In an optional embodiment of the present application, the constant current stimulation unit also includes a third transistor, the gate of the third transistor is connected to the charge balance control signal, the source of the third transistor is grounded, and the drain of the third transistor is connected to the source of the seventh transistor and the drain of the second transistor.

[0021] In an optional embodiment of the present application, the high voltage generation and power management module is implemented using a charge pump circuit.

[0022] In an optional embodiment of the present application, the control module is used to receive external digital configuration instructions, select an even number of the constant current stimulation units to form a number of bipolar stimulation pairs based on the external control instructions, and simultaneously control multiple bipolar stimulation pairs to generate bipolar biphasic current stimulation signals based on the stimulation reference current.

[0023] To achieve the above objectives and other related objectives, the present application provides a multi-channel stimulation system, comprising:

[0024] a plurality of stimulation electrodes; and

[0025] Multi-channel stimulation chip, including:

[0026] A reconfigurable stimulation drive array includes a plurality of independent constant current stimulation units, each of which serves as a stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair, each of which is connected to one of the stimulation electrodes;

[0027] A current generating module, used for generating a stimulation reference current required by each of the constant current stimulation units;

[0028] a control module, configured to receive an external digital configuration instruction, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instruction, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current; and

[0029] High voltage generation and power management modules that convert voltage sources into supply voltage supplies.

[0030] As described above, the multi-channel stimulation chip and multi-channel stimulation system of the present application adopt a reconfigurable stimulation drive array, which includes a number of independent constant current stimulation units, each of which serves as an independent stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair, so that the constant current stimulation units can be freely paired by spatial programming according to external digital configuration instructions, thereby forming a rich bipolar stimulation pairing combination to meet diverse stimulation needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 A schematic diagram of the overall architecture of a multi-channel stimulation chip provided in an embodiment of the present application;

[0032] Figure 2 Shown is a schematic diagram of a constant current stimulation unit provided in an embodiment of the present application;

[0033] Figure 3 A schematic diagram showing a bipolar stimulation pair consisting of any two constant current stimulation units provided in an embodiment of the present application;

[0034] Figure 4 Shown is a circuit diagram of a constant current stimulation unit provided by an embodiment of the present application;

[0035] Figure 5 Another circuit diagram of a constant current stimulation unit provided in one embodiment of the present application is shown. DETAILED DESCRIPTION

[0036] The following describes the embodiments of the present application through specific examples, and those skilled in the art can easily understand other advantages and effects of the present application from the contents disclosed in this specification. The present application can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present application. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0038] It is understood that the terms "first", "second", etc. used in this application may be used herein to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish a first element from another element. For example, without departing from the scope of this application, a first transistor may be referred to as a second transistor, and similarly, a second transistor may be referred to as a first transistor. Both the first transistor and the second transistor are transistors, but they are not the same transistor.

[0039] like Figure 1-5 As shown, the present application provides a multi-channel stimulation chip 100 for neural electrical stimulation, which is mainly composed of a reconfigurable stimulation drive array 10, a current generating module 30, a control module 40 and a high voltage production and power management module 20.

[0040] In this embodiment, the reconfigurable stimulation drive array 10 includes a plurality of independent constant current stimulation units, each of which can be used as a stimulation channel, and any two of the constant current stimulation units can be freely paired to form a bipolar stimulation pair. The operation of any configured multiple bipolar stimulation pairs is completely independent, and multiple bipolar stimulation pairs can be operated simultaneously without any crosstalk.

[0041] Define the number of constant current stimulation units of the reconfigurable stimulation drive array 10 as N, then the bipolar stimulation pairs can have N*(N-1) pairing methods to meet diverse stimulation needs. N is usually an even number, so that each constant current stimulation unit can form a multi-level stimulation pair with another constant current stimulation unit. Figure 1 and Figure 2 The reconfigurable stimulation drive array 10 including 32 constant current stimulation units is shown as an example, which are respectively used as channel 0, channel 1, channel 2, channel 3, ..., channel 30 and channel 31. There are 992 ways of pairing bipolar stimulation pairs. It can be understood that in other embodiments, N can also be an odd number.

[0042] See also Figure 2-3As shown, in the present application, the constant current stimulation unit includes a pull-up path with a high-voltage side current source and a pull-down path with a low-voltage side current source; one end of the pull-up path is connected to the power supply voltage VDD (the power supply voltage VDD can be 9V or other suitable values), and the other end is connected to one end of the pull-down path, and the other end of the pull-down path is grounded or connected to a negative power supply VSS. The connection point of the pull-up path and the pull-down path is connected to the stimulation electrode E, and the pull-up path is provided with a switch element for controlling its opening or closing, such as a MOS tube, and the pull-down path is also provided with a switch device for controlling its opening or closing, such as a MOS tube. The stimulation electrode E can be attached to the skin surface or implanted in the body.

[0043] See also Figure 2-3 As shown, in order to achieve free pairing, each of the constant current stimulation units has two different operating modes, which are defined as a first operating mode (Mode A) and a second operating mode (Mode B). In the first operating mode and the second operating mode, the opening order of the pull-up path and the pull-down path of the constant current stimulation unit is exactly opposite, and only one of the pull-up path and the pull-down path of the constant current stimulation unit is opened at the same time.

[0044] One of the constant current stimulation units constituting the bipolar stimulation pair operates in a first operating mode, and the other constant current stimulation unit operates in a second operating mode, so that the pull-up path of the constant current stimulation unit operating in the first operating mode and the pull-down path of the constant current stimulation unit operating in the second operating mode are opened at the same time; the pull-down path of the constant current stimulation unit operating in the first operating mode and the pull-up path of the constant current stimulation unit operating in the second operating mode are opened at the same time, and it is ensured that when the pull-up path of the same constant current stimulation unit is opened, the pull-down path is closed, and when the pull-down path is opened, the pull-up path is closed, so that the stimulation current first passes through the pull-up path and the stimulation electrode (as the anode electrode) of one constant current stimulation unit in the bipolar stimulation pair, passes through the tissue to be stimulated, and then flows to the stimulation electrode (as the cathode electrode) and the pull-down path of the other constant current stimulation unit in the bipolar stimulation pair to achieve electrical stimulation.

[0045] See also Figure 2-3 As shown, in the first operation mode, the CAT control signal (as the low-voltage side control signal) and the ANO control signal (as the high-voltage side control signal) are applied to the pull-down path and the pull-up path, respectively. In the second operation mode, the CAT control signal (as the high-voltage side control signal) and the ANO control signal (as the low-voltage side control signal) are applied to the pull-up path and the pull-down path, respectively.

[0046] Two constant current stimulation units respectively configured in the first operation mode and the second operation mode can be used to form a bipolar stimulation pair, such as Figure 3When the CAT control signal is high, the pull-down path of channel X and the pull-up path of channel Y are turned on; when the ANO control signal is high, the pull-up path of channel X and the pull-down path of channel Y are turned on. Therefore, the stimulation current Ist flows through the tissue in a biphasic manner.

[0047] Figure 4 Another specific circuit diagram of the constant current stimulation unit is given. Figure 4 The constant current stimulation unit can be composed of a high-voltage side current source, a low-voltage side current source and a transistor circuit.

[0048] Wherein, the transistor circuit includes a first transistor Q1 and a second transistor Q8; the source of the first transistor Q1 is connected to a high-voltage side current source (also called a positive power supply side current source), the gate of the first transistor Q1 is connected to a high-voltage side control signal, the drain of the first transistor Q1 is connected to the drain of the second transistor Q8, the source of the second transistor Q8 is connected to a low-voltage side current source (also called a ground side current source or a negative power supply current source), and the gate of the second transistor Q8 is connected to a low-voltage side control signal. Wherein, the first transistor Q1 and the high-voltage side current source constitute the pull-up path of the constant current stimulation unit, and the second transistor Q8 and the low-voltage side current source constitute the pull-down path of the constant current stimulation unit. Wherein, the first transistor Q1 is a PMOS tube, and the second transistor Q8 is an NMOS tube.

[0049] See also Figure 4 In order to maintain charge balance during electrical stimulation, the constant current stimulation unit further includes a third transistor Q9, the gate of the third transistor Q9 is connected to the charge balance control signal, the source of the third transistor Q9 is grounded, and the drain of the third transistor Q9 is connected to the drain of the first transistor Q1 and the drain of the second transistor Q8. As an example, the third transistor can be an NMOS tube.

[0050] Figure 5 Another specific circuit diagram of the constant current stimulation unit is given. Figure 5 The constant current stimulation unit can be composed of a high-voltage side current source, a low-voltage side current source and a transistor circuit.

[0051] Wherein, the transistor circuit includes first to eighth transistors; the source of the first transistor Q1 is connected to the high-voltage side current source, the gate of the first transistor Q1 is connected to the high-voltage side control signal, the drain of the first transistor Q1 is connected to the source of the eighth transistor Q2, the gate of the eighth transistor Q2 is connected to the first bias voltage (bias voltage 1) and the drain of the ninth transistor Q3, the drain of the eighth transistor Q2 is connected to the gate of the ninth transistor Q3 and the source of the fourth transistor Q4, the source of the ninth transistor Q3, the gate of the fourth transistor Q4 and the fifth The gate of transistor Q5 is connected to the source of the sixth transistor Q6, the drain of the fourth transistor Q4 and the drain of the fifth transistor Q5 are connected to the stimulation electrode, the source of the fifth transistor Q5 is connected to the gate of the sixth transistor Q6 and the drain of the seventh transistor Q7, the drain of the sixth transistor Q6 and the gate of the seventh transistor Q7 are connected to the second bias voltage (bias voltage 2), the source of the seventh transistor Q7 is connected to the drain of the second transistor, the source of the second transistor Q8 is connected to the low-voltage side current source, and the gate of the second transistor Q8 is connected to the low-voltage side control signal. As an example, the first bias voltage can be 6V, of course, it can also be other suitable values, the second bias voltage is the voltage source voltage, such as 3.3V, of course, it can also be other suitable values.

[0052] Wherein, the first transistor Q1, the eighth transistor Q2, the fourth transistor Q4 and the high-voltage side current source constitute the pull-up path of the constant current stimulation unit, and the fifth transistor Q5, the seventh transistor Q7, the second transistor Q8 and the low-voltage side current source constitute the pull-down path of the constant current stimulation unit. Wherein, the first transistor Q1, the eighth transistor Q2, the fourth transistor Q4 and the sixth transistor Q6 are PMOS tubes, and the ninth transistor Q3, the fifth transistor Q5, the seventh transistor Q7 and the second transistor Q8 are NMOS tubes.

[0053] See also Figure 5 In order to maintain charge balance during electrical stimulation, the constant current stimulation unit further includes a third transistor Q9, the gate of the third transistor Q9 is connected to a charge balance control signal, the source of the third transistor Q9 is grounded (or connected to a negative power supply), the drain of the third transistor Q9 is connected to the source of the seventh transistor Q7 and the drain of the second transistor Q8, thereby forming a charge balanced discharge path, and the charge balance control signal is used to control the charge balanced discharge path. As an example, the third transistor can be an NMOS tube.

[0054] It should be noted that, in other embodiments, the constant current stimulation unit may also adopt other transistor circuit structures, and is not limited to Figure 4 and Figure 5 .

[0055] In the present embodiment, the high voltage generation and power management module 20 is used to convert the voltage source into a power supply voltage VDD and a bias voltage. The high voltage generation and power management module 20 may, for example, be implemented by a charge pump circuit (also referred to as a DC / DC converter based on a charge pump), and of course, other types of DC / DC converters may also be used. As an example, the voltage source is, for example, a 3.3V button battery, and the 3.3V voltage source may be converted into a 9V power supply voltage and a 6V bias voltage based on a charge pump circuit, thereby providing a power supply voltage and a bias voltage for the constant current stimulation unit, so that the constant current stimulation can provide a controllable and repeatable stimulation effect under various tissue impedances.

[0056] In this embodiment, the current generating module 30 is used to generate the required stimulation reference current of each constant current stimulation unit, and the stimulation reference current is used as the reference current copied by the high-voltage side current source and the low-voltage side current source of the constant current stimulation unit. The current generating module 30 can use a multi-bit DAC digital analog converter, so as to generate a multi-level adjustable stimulation reference current. Taking an 8-bit DAC digital analog converter as an example, a 256-level DAC digital analog converter can be generated, covering a range from 1μA to 256μA.

[0057] In this embodiment, the control module 40 is connected to the external interface 50, and is used to receive external digital configuration instructions through the external interface 50, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instructions, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current to perform neural electrical stimulation.

[0058] It should be noted that, under normal circumstances, several bipolar stimulation pairs are required to perform electrical stimulation. The control module 40 can select an even number of the constant current stimulation units to form several bipolar stimulation pairs based on the external control instructions, and simultaneously control multiple bipolar stimulation pairs to generate bipolar biphasic current stimulation signals based on the stimulation reference current for neural electrical stimulation.

[0059] The present application also discloses a multi-channel stimulation system, which comprises a plurality of stimulation electrodes for applying electrical stimulation to tissues; and the multi-channel stimulation chip 100 mentioned above.

[0060] The multi-channel stimulation chip 100 includes a reconfigurable stimulation drive array 10, including a plurality of independent constant current stimulation units, each of which serves as a stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair, each of which is connected to a stimulation electrode; a current generating module 30, used to generate the stimulation reference current required by each of the constant current stimulation units; a control module 40, used to receive external digital configuration instructions, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instructions, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current; and a high voltage production and power management module 10, used to convert a voltage source into a power supply voltage and a bias voltage.

[0061] In summary, the multi-channel stimulation chip 100 and the multi-channel stimulation system disclosed in the present application adopt a reconfigurable stimulation drive array, which includes a number of independent constant current stimulation units, each of which serves as an independent stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair, so that the constant current stimulation units can be freely paired according to the external digital configuration instructions, forming a rich combination of bipolar stimulation pairings to meet the diverse stimulation needs. Therefore, the present application effectively overcomes the various shortcomings of the prior art and has a high industrial utilization value.

[0062] The above embodiments are merely illustrative of the principles and effects of the present application and are not intended to limit the present application. Anyone familiar with the technology may modify or change the above embodiments without violating the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by a person of ordinary skill in the art without departing from the spirit and technical ideas disclosed in the present application shall still be covered by the claims of the present application.

Claims

1. A multi-channel stimulation chip, characterized in that: include: A reconfigurable stimulation drive array includes a plurality of independent constant current stimulation units, each of which serves as a stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair; A current generating module, used for generating a stimulation reference current required by each of the constant current stimulation units; A control module, configured to receive an external digital configuration instruction, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instruction, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current; High voltage generation and power management modules that convert voltage sources into supply voltage supplies.

2. The multi-channel stimulation chip according to claim 1, characterized in that: The current generating module adopts a multi-bit DAC digital analog converter.

3. The multi-channel stimulation chip according to claim 1, characterized in that: The constant current stimulation unit includes a pull-up path with a high-voltage side current source and a pull-down path with a low-voltage side current source; one end of the pull-up path is connected to the power supply voltage power source, and the other end is connected to one end of the pull-down path, and the other end of the pull-down path is grounded or connected to a negative power supply, and the connection point between the pull-up path and the pull-down path is connected to the stimulation electrode.

4. The multi-channel stimulation chip according to claim 3, characterized in that: The constant current stimulation unit has a first operation mode and a second operation mode. In the first operation mode and the second operation mode, the opening order of the pull-up path and the pull-down path of the constant current stimulation unit is opposite.

5. The multi-channel stimulation chip according to claim 4, characterized in that: One of the constant current stimulation units constituting the bipolar stimulation pair operates in a first operation mode, and the other constant current stimulation unit operates in a second operation mode.

6. The multi-channel stimulation chip according to claim 1, characterized in that: The constant current stimulation unit includes a high-voltage side current source, a low-voltage side current source and a transistor circuit; The transistor circuit includes a first transistor and a second transistor; The source of the first transistor is connected to a high-voltage side current source, the gate of the first transistor is connected to a high-voltage side control signal, the drain of the first transistor is connected to a drain of the second transistor, the source of the second transistor is connected to a low-voltage side current source, and the gate of the second transistor is connected to a low-voltage side control signal.

7. The multi-channel stimulation chip according to claim 6, characterized in that: The constant current stimulation unit also includes a third transistor, the gate of the third transistor is connected to the charge balance control signal, the source of the third transistor is grounded, and the drain of the third transistor is connected to the drain of the first transistor and the drain of the second transistor.

8. The multi-channel stimulation chip according to claim 1, characterized in that: The high voltage generation and power management module is implemented using a charge pump circuit.

9. The multi-channel stimulation chip according to claim 1, characterized in that: The control module is used to receive external digital configuration instructions, select an even number of the constant current stimulation units to form a plurality of bipolar stimulation pairs based on the external control instructions, and simultaneously control a plurality of the bipolar stimulation pairs to generate bipolar biphasic current stimulation signals based on the stimulation reference current.

10. A multi-channel stimulation system, characterized in that: include: A number of stimulation electrodes; as well as Multi-channel stimulation chip, including: A reconfigurable stimulation drive array includes a plurality of independent constant current stimulation units, each of which serves as a stimulation channel, and any two of which can be freely paired to form a bipolar stimulation pair, each of which is connected to one of the stimulation electrodes; A current generating module, used for generating a stimulation reference current required by each of the constant current stimulation units; a control module, configured to receive an external digital configuration instruction, select at least two of the constant current stimulation units to form a bipolar stimulation pair based on the external control instruction, and control the bipolar stimulation pair to generate a bipolar biphasic current stimulation signal based on the stimulation reference current; and High voltage generation and power management modules that convert voltage sources to supply voltages.

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